45 results on '"Cohuet, S."'
Search Results
2. Characteristics of human encounters and social mixing patterns relevant to infectious diseases spread by close contact: a survey in Southwest Uganda
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le Polain de Waroux, O., Cohuet, S., Ndazima, D., Kucharski, A. J., Juan-Giner, A., Flasche, S., Tumwesigye, E., Arinaitwe, R., Mwanga-Amumpaire, J., Boum, II, Y., Nackers, F., Checchi, F., Grais, R. F., and Edmunds, W. J.
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- 2018
- Full Text
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3. Epidemiology of internal contamination with polonium-210 in the London incident, 2006
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Fraser, G, Giraudon, I, Cohuet, S, Bishop, L, Maguire, H, Thomas, H L, Mandal, S, Anders, K, Sanchez-Padilla, E, Charlett, A, Evans, B, and Gross, R
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- 2012
4. A Measles Outbreak in the Irish Traveller Ethnic Group after Attending a Funeral in England, March-June 2007
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Cohuet, S., Bukasa, A., Heathcock, R., White, J., Brown, K., Ramsay, M., and Fraser, G.
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- 2009
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5. Le paludisme en France : métropole et outre-mer
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Tarantola, A., Eltges, F., Ardillon, V., Lernout, T., Sissoko, D., Kendjo, E., Achirafi, A., Thiria, J., Flamand, C., D’Ortenzio, E., Cohuet, S., Quatresous, I., Quenel, P., Filleul, L., and Gastellu-Etchegorry, M.
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- 2011
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6. COMPARISON OF MUAC AND PERCENT WEIGHT GAIN AS DISCHARGE CRITERION IN A LARGE TFP PROGRAM IN BURKINA FASO - 2007-2011: O086
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Cohuet, S., Goossens, S., Shepherd, S., Shaefer, M., and Munger, A.
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- 2013
7. Field challenges to measles elimination in the Democratic Republic of the Congo
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Coulborn, R.M., primary, Nackers, F., additional, Bachy, C., additional, Porten, K., additional, Vochten, H., additional, Ndele, E., additional, Van Herp, M., additional, Bibala-Faray, E., additional, Cohuet, S., additional, and Panunzi, I., additional
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- 2020
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8. Alternative observational designs to estimate the effectiveness of one dose of oral cholera vaccine in Lusaka, Zambia
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Ferreras, E., primary, Blake, A., additional, Chewe, O., additional, Mwaba, J., additional, Zulu, G., additional, Poncin, M., additional, Rakesh, A., additional, Page, A. L., additional, Quilici, M. L., additional, Azman, A. S., additional, Cohuet, S., additional, Ciglenecki, I., additional, Malama, K., additional, Chizema-Kawesha, E., additional, and Luquero, F. J., additional
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- 2020
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9. Characteristics of human encounters and social mixing patterns relevant to infectious diseases spread by close contact: A survey in southwest Uganda
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de Waroux, O le Polain, primary, Cohuet, S, additional, Ndazima, D, additional, Kucharski, A J, additional, Juan-Giner, A, additional, Flasche, S, additional, Tumwesigye, E, additional, Arinaitwe, R., additional, Mwanga-Amumpaire, J, additional, Boum, Y, additional, Nackers, F, additional, Checchi, F, additional, Grais, R F, additional, and Edmunds, W J, additional
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- 2017
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10. Epidemiology, surveillance and control of infectious diseases in the European overseas countries and territories, 2011
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Jones J, Gastellu-Etchegorry M, Fk, Stenz, Baudon C, Sj, Bloem, Bondonneau M, Cohuet S, Diggle R, Rw, Ewing, Gerstenbluth I, Jp, Grangeon, Kumar Alla K, Lajoinie G, Tromp M, Tumahai T, Jf, Yvon, Cm, Swaan, and Celine M. Gossner
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Europe ,International Cooperation ,Population Surveillance ,Communicable Disease Control ,Humans ,European Union ,Public Health ,Communicable Diseases ,Disease Outbreaks - Abstract
The 25 European overseas countries and territories (OCTs) are closely associated with the European Union (EU) through the four related UE Member States: Denmark, France, the Netherlands and the United Kingdom. In 2008 and 2009, these four EU Member States, in association with the European Centre for Disease Prevention and Control (ECDC), reviewed the OCTs’ needs, with the objectives of documenting their capacity to prevent and respond to infectious diseases outbreaks, and identifying deficiencies. This Euroroundup is based on the review’s main findings, and presents an overview of the OCTs’ geography and epidemiology, briefly introduces the legal basis on which they are linked to the EU and describes the surveillance and infectious disease response systems. As a result of their diversity the OCTs have heterogeneous epidemiological profiles. A common factor, however, is that the main burden of disease is non-communicable. Nevertheless, OCTs remain vulnerable to infectious diseases outbreaks. Their capacity for surveillance, early detection and response to such outbreaks is generally limited, with laboratory capacity issues and lack of human resources. Avenues for capacity strengthening should be explored by the OCTs and the related EU Member States, in collaboration with ECDC and regional public health networks where these exist.
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- 2011
11. Epidemiology of internal contamination with polonium-210 in the London incident, 2006
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Fraser, G, primary, Giraudon, I, additional, Cohuet, S, additional, Bishop, L, additional, Maguire, H, additional, Thomas, H L, additional, Mandal, S, additional, Anders, K, additional, Sanchez-Padilla, E, additional, Charlett, A, additional, Evans, B, additional, and Gross, R, additional
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- 2011
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12. Against the Odds: Psychomotor Development of Children Under 2 years in a Sudanese Orphanage
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Espie, E., primary, Ouss, L., additional, Gaboulaud, V., additional, Candilis, D., additional, Ahmed, K., additional, Cohuet, S., additional, Baubet, T., additional, Grais, R. F., additional, and Moro, M.-R., additional
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- 2011
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13. Setting up an enhanced surveillance of newly acquired hepatitis C infection in men who have sex with men: a pilot in London and South East region of England
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Ruf, M, primary, Cohuet, S, additional, Maguire, H, additional, Brant, L J, additional, Ramsay, M, additional, Lattimore, S, additional, Delpech, V, additional, and the SNAHC steering group, Collective, additional
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- 2008
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14. Outbreak of measles among Irish Travellers in England, March to May 2007
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Cohuet, S, primary, Morgan, O, additional, Bukasa, A, additional, Heathcock, R, additional, White, J, additional, Brown, K, additional, Ramsay, M, additional, and Gross, R, additional
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- 2007
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15. P118 - Rôles des androgènes dans la mise en place de la lignée germinale mâle
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Merlet, J., primary, Moreau, E., additional, Cohuet, S., additional, Racine, C., additional, and Habert, R., additional
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- 2005
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16. Epidemiology, surveillance and control of infectious diseases in the European overseas countries and territories, 2011.
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Jones, J., gorry, M. Gastellu-Etche, Stenz, F. K, Baudon, C., Bloem, S. J., Bondonneau, M., Cohuet, S., Diggle, R., Ewing, R. W., Gerstenbluth, I., Grangeon, J. P., Alla, K. Kumar, Lajoinie, G., Tromp, M., Tumahai, T., Yvon, J. F., Swaan, C. M., and Gossner, C. M.
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- 2011
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17. Setting up an enhanced surveillance of newly acquired hepatitis C infection in men who have sex with men: a pilot in London and South East region of England
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Ruf, M., Cohuet, S., Maguire, H., Brant, L. J., Ramsay, M., Lattimore, S., and valerie delpech
18. Outbreak of measles among Irish Travellers in England, March to May 2007
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Cohuet, S., Morgan, O., Bukasa, A., Heathcock, R., Joanne White, Brown, K., Ramsay, M., and Gross, R.
19. High cholera vaccination coverage following emergency campaign in Haiti: Results from a cluster survey in three rural Communes in the South Department, 2017.
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Sharp A, Blake A, Backx J, Panunzi I, Barrais R, Nackers F, Luquero F, Deslouches YG, and Cohuet S
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- Adolescent, Adult, Child, Child, Preschool, Cholera epidemiology, Cholera Vaccines supply & distribution, Cluster Analysis, Data Collection, Disease Outbreaks, Family Characteristics, Female, Haiti epidemiology, Humans, Infant, Male, Rural Population, Cholera prevention & control, Cholera Vaccines administration & dosage, Mass Vaccination methods, Vaccination Coverage
- Abstract
Oral cholera vaccine (OCV) has increasingly been used as an outbreak control measure, but vaccine shortages limit its application. A two-dose OCV campaign targeting residents aged over 1 year was launched in three rural Communes of Southern Haiti during an outbreak following Hurricane Matthew in October 2016. Door-to-door and fixed-site strategies were employed and mobile teams delivered vaccines to hard-to-reach communities. This was the first campaign to use the recently pre-qualified OCV, Euvichol. The study objective was to estimate post-campaign vaccination coverage in order to evaluate the campaign and guide future outbreak control strategies. We conducted a cluster survey with sampling based on random GPS points. We identified clusters of five households and included all members eligible for vaccination. Local residents collected data through face-to-face interviews. Coverage was estimated, accounting for the clustered sampling, and 95% confidence intervals calculated. 435 clusters, 2,100 households and 9,086 people were included (99% response rate). Across the three communes respectively, coverage by recall was: 80.7% (95% CI:76.8-84.1), 82.6% (78.1-86.4), and 82.3% (79.0-85.2) for two doses and 94.2% (90.8-96.4), 91.8% (87-94.9), and 93.8% (90.8-95.9) for at least one dose. Coverage varied by less than 9% across age groups and was similar among males and females. Participants obtained vaccines from door-to-door vaccinators (53%) and fixed sites (47%). Most participants heard about the campaign through community 'criers' (58%). Despite hard-to-reach communities, high coverage was achieved in all areas through combining different vaccine delivery strategies and extensive community mobilisation. Emergency OCV campaigns are a viable option for outbreak control and where possible multiple strategies should be used in combination. Euvichol will help alleviate the OCV shortage but effectiveness studies in outbreaks should be done., Competing Interests: The authors have declared that no competing interests exist.
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- 2020
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20. Delayed second dose of oral cholera vaccine administered before high-risk period for cholera transmission: Cholera control strategy in Lusaka, 2016.
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Ferreras E, Matapo B, Chizema-Kawesha E, Chewe O, Mzyece H, Blake A, Moonde L, Zulu G, Poncin M, Sinyange N, Kasese-Chanda N, Phiri C, Malama K, Mukonka V, Cohuet S, Uzzeni F, Ciglenecki I, Danovaro-Holliday MC, Luquero FJ, and Pezzoli L
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- Administration, Oral, Adolescent, Adult, Child, Cholera epidemiology, Cholera Vaccines immunology, Disease Outbreaks prevention & control, Dose-Response Relationship, Immunologic, Female, Humans, Male, Risk, Time Factors, Young Adult, Zambia epidemiology, Cholera prevention & control, Cholera transmission, Cholera Vaccines administration & dosage, Vaccination methods
- Abstract
Background: In April 2016, an emergency vaccination campaign using one dose of Oral Cholera Vaccine (OCV) was organized in response to a cholera outbreak that started in Lusaka in February 2016. In December 2016, a second round of vaccination was conducted, with the objective of increasing the duration of protection, before the high-risk period for cholera transmission. We assessed vaccination coverage for the first and second rounds of the OCV campaign., Methods: Vaccination coverage was estimated after each round from a sample selected from targeted-areas for vaccination using a cross-sectional survey in to establish the vaccination status of the individuals recruited. The study population included all individuals older than 12 months residing in the areas targeted for vaccination. We interviewed 505 randomly selected individuals after the first round and 442 after the second round. Vaccination status was ascertained either by vaccination card or verbal reporting. Households were selected using spatial random sampling., Results: The vaccination coverage with two doses was 58.1% (25/43; 95%CI: 42.1-72.9) in children 1-5 years old, 59.5% (69/116; 95%CI: 49.9-68.5) in children 5-15 years old and 19.9% (56/281; 95%CI: 15.4-25.1) in adults above 15 years old. The overall dropout rate was 10.9% (95%CI: 8.1-14.1). Overall, 69.9% (n = 309/442; 95%CI: 65.4-74.1) reported to have received at least one OCV dose., Conclusions: The areas at highest risk of suffering cholera outbreaks were targeted for vaccination obtaining relatively high vaccine coverage after each round. However, the long delay between doses in areas subject to considerable population movement resulted in many individuals receiving only one OCV dose. Additional vaccination campaigns may be required to sustain protection over time in case of persistence of risk. Further evidence is needed to establish a maximum optimal interval time of a delayed second dose and variations in different settings., Competing Interests: The authors have declared that no competing interests exist.
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- 2019
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21. Measles seroprevalence after reactive vaccination campaigns during the 2015 measles outbreak in four health zones of the former Katanga Province, Democratic Republic of Congo.
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Keating P, Carrion Martin AI, Blake A, Lechevalier P, Uzzeni F, Gignoux E, Okonta C, Langendorf C, Smit S, Ahuka S, Suchard M, Pukuta E, Degail MA, Hansen L, Kibanza-Kyungu J, Ciglenecki I, and Cohuet S
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- Adolescent, Child, Child, Preschool, Democratic Republic of the Congo epidemiology, Female, Humans, Infant, Male, Measles prevention & control, Seroepidemiologic Studies, Disease Outbreaks prevention & control, Immunization Programs, Measles epidemiology, Measles Vaccine administration & dosage
- Abstract
Background: Measles continues to circulate in the Democratic Republic of Congo, and the country suffered from several important outbreaks over the last 5 years. Despite a large outbreak starting in the former province of Katanga in 2010 and the resulting immunization activities, another outbreak occurred in 2015 in this same region. We conducted measles seroprevalence surveys in four health zones (HZ) in the former Katanga Province in order to assess the immunity against measles in children 6 months to 14 years after the 2015 outbreak., Methods: We conducted multi-stage cluster surveys stratified by age group in four HZs, Kayamba, Malemba-Nkulu, Fungurume, and Manono. The age groups were 6-11 months, 12-59 months, and 5-14 years in Kayamba and Malemba-Nkulu, 6-59 months and 5-14 years in Manono and Fungurume. The serological status was measured on dried capillary blood spots collected systematically along with vaccination status (including routine Extended Program of Immunization (EPI), and supplementary immunization activities (SIAs)) and previous self-reported history of suspected measles., Results: Overall seroprevalence against measles was 82.7% in Kayamba, 97.6% in Malemba-Nkulu, 83.2% in Manono, and 74.4% in Fungurume, and it increased with age in all HZs. It was 70.7 and 93.8% in children 12-59 months in Kayamba and Malemba-Nkulu, and 49.8 and 64.7% in children 6-59 months in Fungurume and Manono. The EPI coverage was low but varied across HZ. The accumulation of any type of vaccination against measles resulted in an overall vaccine coverage (VC) of at least 85% in children 12-59 months in Kayamba and Malemba-Nkulu, 86.1 and 74.8% in children 6-59 months in Fungurume and Manono. Previous measles infection in 2015-early 2016 was more frequently reported in children aged 12-59 months or 6-59 months (depending on the HZ)., Conclusion: The measured seroprevalence was consistent with the events that occurred in these HZs over the past few years. Measles seroprevalence might prove a valuable source of information to help adjust the timing of future SIAs and prioritizing support to the EPI in this region as long as the VC does not reach a level high enough to efficiently prevent epidemic flare-ups.
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- 2019
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22. Effectiveness of oral cholera vaccine in preventing cholera among fishermen in Lake Chilwa, Malawi: A case-control study.
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Grandesso F, Kasambara W, Page AL, Debes AK, M'bang'ombe M, Palomares A, Lechevalier P, Pezzoli L, Alley I, Salumu L, Msyamboza K, Sack D, Cohuet S, and Luquero FJ
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- Administration, Oral, Adult, Case-Control Studies, Diarrhea immunology, Diarrhea parasitology, Disease Outbreaks prevention & control, Female, Humans, Lakes parasitology, Malawi, Male, Vaccination methods, Vibrio cholerae immunology, Young Adult, Cholera immunology, Cholera Vaccines immunology
- Abstract
Background: In response to a cholera outbreak among mobile, difficult-to-reach fishermen on Lake Chilwa, Malawi in 2016, a novel vaccine distribution strategy exploited the proven vaccine thermostability. Fishermen, while taking the first vaccine dose under supervision, received the second dose in a sealed bag, and were told to drink it two weeks later. This study assessed short-term vaccine protection of this strategy., Methods: Patients with diarrhoea admitted to health facilities around lake were interviewed and a stool sample collected for PCR testing. Vaccine effectiveness was assessed in a case-control test-negative design by comparing cases (PCR-positive for V. cholerae O1) and controls (patients with diarrhoea but PCR-negative) and with the screening method that compared the proportions of vaccinated among cholera cases versus the general fishermen population., Results: Of 145 study participants, 120 were fishermen living on the lake. Vaccine effectiveness at three-months was 90.0% [95%CI:38.8;98.4] among fishermen and 83.3% [95%CI: 20.8; 96.5] among all participants in the case-control test-negative design, and 97.5% [95%CI: 90.9;99.3] with the screening method., Conclusion: This strategy was effective in providing short-term protection in fishermen against cholera. Further research is needed to determine the adding value of the second dose and to identify the optimal vaccination strategies for different contexts., (Copyright © 2019. Published by Elsevier Ltd.)
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- 2019
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23. MUAC as the sole discharge criterion from community-based management of severe acute malnutrition in Burkina Faso.
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Isanaka S, Hanson KE, Frison S, Andersen CT, Cohuet S, and Grais RF
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- Burkina Faso, Child, Preschool, Community Health Centers, Female, Humans, Infant, Male, Retrospective Studies, Treatment Outcome, Anthropometry methods, Arm physiology, Patient Discharge statistics & numerical data, Severe Acute Malnutrition diet therapy
- Abstract
The use of mid upper arm circumference (MUAC) measurement to screen and determine eligibility for admission to therapeutic feeding programs has been established, but evidence and programmatic experience to inform guidance on the use of MUAC as a discharge criterion is limited. We present results from a large-scale nutritional program using MUAC for admission and discharge and compare program outcomes and response to treatment when determining eligibility for discharge by proportional weight gain versus discharge by MUAC. The study population included all children admitted to the Ministry of Health therapeutic feeding program supported by Médecins Sans Frontières in northern Burkina Faso from September 2007 to December 2011 (n = 50,841). Recovery was high overall using both discharge criteria, with low risks of death, nonresponse, and transfer to inpatient care and high daily gains in weight, MUAC, weight-for-height Z score, and height. When discharge was made by MUAC only, recovery increased, while all adverse program outcomes and length of stay decreased, with increasing MUAC on admission. MUAC-based programming, where MUAC is integrated into program screening, admission, and discharge, is one of several new approaches that can be used to target resources to the most at-risk malnourished children and improve program efficiency and coherency. This analysis provides additional programmatic experience on the use of MUAC-based discharge criterion, but more work may be needed to inform optimal discharge thresholds across settings., (© 2018 The Authors. Maternal and Child Nutrition Published by John Wiley & Sons, Ltd.)
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- 2019
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24. Urban yellow fever outbreak-Democratic Republic of the Congo, 2016: Towards more rapid case detection.
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Ingelbeen B, Weregemere NA, Noel H, Tshapenda GP, Mossoko M, Nsio J, Ronsse A, Ahuka-Mundeke S, Cohuet S, and Kebela BI
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- Adult, Angola, Democratic Republic of the Congo epidemiology, Disease Outbreaks, Female, Humans, Male, Travel, Urban Population, Yellow Fever diagnosis, Yellow Fever virology, Yellow fever virus genetics, Yellow fever virus isolation & purification, Yellow fever virus physiology, Yellow Fever epidemiology
- Abstract
Background: Between December 2015 and July 2016, a yellow fever (YF) outbreak affected urban areas of Angola and the Democratic Republic of the Congo (DRC). We described the outbreak in DRC and assessed the accuracy of the YF case definition, to facilitate early diagnosis of cases in future urban outbreaks., Methodology/principal Findings: In DRC, suspected YF infection was defined as jaundice within 2 weeks after acute fever onset and was confirmed by either IgM serology or PCR for YF viral RNA. We used case investigation and hospital admission forms. Comparing clinical signs between confirmed and discarded suspected YF cases, we calculated the predictive values of each sign for confirmed YF and the diagnostic accuracy of several suspected YF case definitions. Fifty seven of 78 (73%) confirmed cases had travelled from Angola: 88% (50/57) men; median age 31 years (IQR 25-37). 15 (19%) confirmed cases were infected locally in urban settings in DRC. Median time from symptom onset to healthcare consultation was 7 days (IQR 6-9), to appearance of jaundice 8 days (IQR 7-11), to sample collection 9 days (IQR 7-14), and to hospitalization 17 days (IQR 11-26). A case definition including fever or jaundice, combined with myalgia or a negative malaria test, yielded an improved sensitivity (100%) and specificity (57%)., Conclusions/significance: As jaundice appeared late, the majority of cases were diagnosed too late for supportive care and prompt vector control. In areas with known local YF transmission, a suspected case definition without jaundice as essential criterion could facilitate earlier YF diagnosis, care and control., Competing Interests: The authors have declared that no competing interests exist.
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- 2018
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25. Identifying human encounters that shape the transmission of Streptococcus pneumoniae and other acute respiratory infections.
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le Polain de Waroux O, Flasche S, Kucharski AJ, Langendorf C, Ndazima D, Mwanga-Amumpaire J, Grais RF, Cohuet S, and Edmunds WJ
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- Adolescent, Adult, Carrier State transmission, Child, Child, Preschool, Female, Humans, Male, Pneumococcal Infections prevention & control, Respiratory Tract Infections prevention & control, Sexual Behavior, Sexual Partners, Surveys and Questionnaires, Uganda, Young Adult, Pneumococcal Infections transmission, Respiratory Tract Infections transmission, Social Behavior, Streptococcus pneumoniae
- Abstract
Although patterns of social contacts are believed to be an important determinant of infectious disease transmission, it remains unclear how the frequency and nature of human interactions shape an individual's risk of infection. We analysed data on daily social encounters individually matched to data on S. pneumoniae carriage and acute respiratory symptoms (ARS), from 566 individuals who took part in a survey in South-West Uganda. We found that the frequency of physical (i.e. skin-to-skin), long (≥1 h) and household contacts - which capture some measure of close (i.e. relatively intimate) contact - was higher among pneumococcal carriers than non-carriers, and among people with ARS compared to those without, irrespective of their age. With each additional physical encounter the age-adjusted risk of carriage and ARS increased by 6% (95%CI 2-9%) and 7% (2-13%) respectively. In contrast, the number of casual contacts (<5 min long) was not associated with either pneumococcal carriage or ARS. A detailed analysis by age of contacts showed that the number of close contacts with young children (<5 years) was particularly higher among older children and adult carriers than non-carriers, while the higher number of contacts among people suffering from ARS was more homogeneous across contacts of all ages. Our findings provide key evidence that the frequency of close interpersonal contact is important for transmission of respiratory infections, but not that of casual contacts. Those results are essential for both improving disease prevention and control efforts as well as informing research on infectious disease dynamics and transmission models, and more studies should be undertaken to further validate our results., (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)
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- 2018
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26. Oral cholera vaccination in hard-to-reach communities, Lake Chilwa, Malawi.
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Grandesso F, Rafael F, Chipeta S, Alley I, Saussier C, Nogareda F, Burns M, Lechevalier P, Page AL, Salumu L, Pezzoli L, Mwesawina M, Cavailler P, Mengel M, Luquero FJ, and Cohuet S
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- Adolescent, Child, Child, Preschool, Female, Humans, Infant, Interviews as Topic, Malawi, Male, Qualitative Research, Vaccination Coverage statistics & numerical data, Administration, Oral, Cholera prevention & control, Cholera Vaccines administration & dosage
- Abstract
Objective: To evaluate vaccination coverage, identify reasons for non-vaccination and assess satisfaction with two innovative strategies for distributing second doses in an oral cholera vaccine campaign in 2016 in Lake Chilwa, Malawi, in response to a cholera outbreak., Methods: We performed a two-stage cluster survey. The population interviewed was divided in three strata according to the second-dose vaccine distribution strategy: (i) a standard strategy in 1477 individuals (68 clusters of 5 households) on the lake shores; (ii) a simplified cold-chain strategy in 1153 individuals (59 clusters of 5 households) on islands in the lake; and (iii) an out-of-cold-chain strategy in 295 fishermen (46 clusters of 5 to 15 fishermen) in floating homes, called zimboweras ., Finding: Vaccination coverage with at least one dose was 79.5% (1153/1451) on the lake shores, 99.3% (1098/1106) on the islands and 84.7% (200/236) on zimboweras . Coverage with two doses was 53.0% (769/1451), 91.1% (1010/1106) and 78.8% (186/236), in the three strata, respectively. The most common reason for non-vaccination was absence from home during the campaign. Most interviewees liked the novel distribution strategies., Conclusion: Vaccination coverage on the shores of Lake Chilwa was moderately high and the innovative distribution strategies tailored to people living on the lake provided adequate coverage, even among hard-to-reach communities. Community engagement and simplified delivery procedures were critical for success. Off-label, out-of-cold-chain administration of oral cholera vaccine should be considered as an effective strategy for achieving high coverage in hard-to-reach communities. Nevertheless, coverage and effectiveness must be monitored over the short and long term.
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- 2018
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27. Evaluation of the SD bioline cholera rapid diagnostic test during the 2016 cholera outbreak in Lusaka, Zambia.
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Mwaba J, Ferreras E, Chizema-Kawesa E, Mwimbe D, Tafirenyika F, Rauzier J, Blake A, Rakesh A, Poncin M, Stoitsova S, Kwenda G, Azman AS, Chewe O, Serafini M, Lukwesa-Musyani C, Cohuet S, Quilici ML, Luquero FJ, and Page AL
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- Humans, Polymerase Chain Reaction, Reagent Kits, Diagnostic, Zambia, Cholera diagnosis, Diagnostic Tests, Routine methods, Feces microbiology, Vibrio cholerae isolation & purification
- Abstract
Objective: To assess the performance of the SD Bioline Cholera Ag O1/O139 rapid diagnostic test (RDT) compared to a reference standard combining culture and PCR for the diagnosis of cholera cases during an outbreak., Methods: RDT and bacterial culture were performed on site using fresh stools collected from cholera suspected cases, and from stools enriched in alkaline peptone water. Dried stool samples on filter paper were tested for V. cholerae by PCR in Lusaka (as part of a laboratory technology transfer project) and at a reference laboratory in Paris, France. A sample was considered positive for cholera by the reference standard if any of the culture or PCR tests was positive for V. cholerae O1 or O139., Results: Among the 170 samples tested with SD Bioline and compared to the reference standard, the RDT showed a sensitivity of 90.9% (95% CI: 81.3-96.6) and specificity of 95.2% (95% CI: 89.1-98.4). After enrichment, the sensitivity was 95.5% (95% CI: 87.3-99.1) and specificity 100% (95% CI: 96.5-100)., Conclusion: The observed sensitivity and specificity were within recommendations set by the Global Task Force for Cholera Control on the use of cholera RDT (sensitivity = 90%; specificity = 85%). Although the sample size was small, our findings suggest that the SD Bioline RDT could be used in the field to rapidly alert public health officials to the likely presence of cholera cases when an outbreak is suspected., (© 2018 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd.)
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- 2018
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28. Near real-time forecasting for cholera decision making in Haiti after Hurricane Matthew.
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Pasetto D, Finger F, Camacho A, Grandesso F, Cohuet S, Lemaitre JC, Azman AS, Luquero FJ, Bertuzzo E, and Rinaldo A
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- Decision Making, Forecasting, Haiti, Humans, Incidence, Cholera prevention & control, Cholera transmission, Computer Simulation, Cyclonic Storms, Disease Outbreaks prevention & control, Disease Outbreaks statistics & numerical data
- Abstract
Computational models of cholera transmission can provide objective insights into the course of an ongoing epidemic and aid decision making on allocation of health care resources. However, models are typically designed, calibrated and interpreted post-hoc. Here, we report the efforts of a team from academia, field research and humanitarian organizations to model in near real-time the Haitian cholera outbreak after Hurricane Matthew in October 2016, to assess risk and to quantitatively estimate the efficacy of a then ongoing vaccination campaign. A rainfall-driven, spatially-explicit meta-community model of cholera transmission was coupled to a data assimilation scheme for computing short-term projections of the epidemic in near real-time. The model was used to forecast cholera incidence for the months after the passage of the hurricane (October-December 2016) and to predict the impact of a planned oral cholera vaccination campaign. Our first projection, from October 29 to December 31, predicted the highest incidence in the departments of Grande Anse and Sud, accounting for about 45% of the total cases in Haiti. The projection included a second peak in cholera incidence in early December largely driven by heavy rainfall forecasts, confirming the urgency for rapid intervention. A second projection (from November 12 to December 31) used updated rainfall forecasts to estimate that 835 cases would be averted by vaccinations in Grande Anse (90% Prediction Interval [PI] 476-1284) and 995 in Sud (90% PI 508-2043). The experience gained by this modeling effort shows that state-of-the-art computational modeling and data-assimilation methods can produce informative near real-time projections of cholera incidence. Collaboration among modelers and field epidemiologists is indispensable to gain fast access to field data and to translate model results into operational recommendations for emergency management during an outbreak. Future efforts should thus draw together multi-disciplinary teams to ensure model outputs are appropriately based, interpreted and communicated., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2018
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29. Highly targeted cholera vaccination campaigns in urban setting are feasible: The experience in Kalemie, Democratic Republic of Congo.
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Massing LA, Aboubakar S, Blake A, Page AL, Cohuet S, Ngandwe A, Mukomena Sompwe E, Ramazani R, Allheimen M, Levaillant P, Lechevalier P, Kashimi M, de la Motte A, Calmejane A, Bouhenia M, Dabire E, Bompangue D, Kebela B, Porten K, and Luquero F
- Subjects
- Adolescent, Child, Child, Preschool, Cholera epidemiology, Cross-Sectional Studies, Democratic Republic of the Congo epidemiology, Female, Humans, Infant, Male, Vaccination statistics & numerical data, Cholera prevention & control, Cholera Vaccines administration & dosage
- Abstract
Introduction: Oral cholera vaccines are primarily recommended by the World Health Organization for cholera control in endemic countries. However, the number of cholera vaccines currently produced is very limited and examples of OCV use in endemic countries, and especially in urban settings, are scarce. A vaccination campaign was organized by Médecins Sans Frontières and the Ministry of Health in a highly endemic area in the Democratic Republic of Congo. This study aims to describe the vaccine coverage achieved with this highly targeted vaccination campaign and the acceptability among the vaccinated communities., Methods and Findings: We performed a cross-sectional survey using random spatial sampling. The study population included individuals one year old and above, eligible for vaccination, and residing in the areas targeted for vaccination in the city of Kalemie. Data sources were household interviews with verification by vaccination card. In total 2,488 people were included in the survey. Overall, 81.9% (95%CI: 77.9-85.3) of the target population received at least one dose of vaccine. The vaccine coverage with two doses was 67.2% (95%CI: 61.9-72.0) among the target population. The vaccine coverage was higher during the first round (74.0, 95%CI: 69.3-78.3) than during the second round of vaccination (69.1%, 95%CI: 63.9-74.0). Vaccination coverage was lower in male adults. The main reason for non-vaccination was to be absent during the campaign. No severe adverse events were notified during the interviews., Conclusions: Cholera vaccination campaigns using highly targeted strategies are feasible in urban settings. High vaccination coverage can be obtained using door to door vaccination. However, alternative strategies should be considered to reach non-vaccinated populations like male adults and also in order to improve the efficiency of the interventions., Competing Interests: Some MSF field representatives who coordinated the data collection were involved in the preparation of the manuscript but not in the analysis. There are no other competing interests.
- Published
- 2018
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30. Syrian refugees in Greece: experience with violence, mental health status, and access to information during the journey and while in Greece.
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Ben Farhat J, Blanchet K, Juul Bjertrup P, Veizis A, Perrin C, Coulborn RM, Mayaud P, and Cohuet S
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Cross-Sectional Studies, Female, Greece, Humans, Male, Syria, Young Adult, Access to Information psychology, Mental Health ethnology, Refugees psychology, Violence ethnology
- Abstract
Background: Since 2015, Europe has been facing an unprecedented arrival of refugees and migrants: more than one million people entered via land and sea routes. During their travels, refugees and migrants often face harsh conditions, forced detention, and violence in transit countries. However, there is a lack of epidemiological quantitative evidence on their experiences and the mental health problems they face during their displacement. We aimed to document the types of violence experienced by migrants and refugees during their journey and while settled in Greece, and to measure the prevalence of anxiety disorders and access to legal information and procedures., Methods: We conducted a cross-sectional population-based quantitative survey combined with an explanatory qualitative study in eight sites (representing the range of settlements) in Greece during winter 2016/17. The survey consisted of a structured questionnaire on experience of violence and an interviewer-administered anxiety disorder screening tool (Refugee Health Screener)., Results: In total, 1293 refugees were included, of whom 728 were Syrians (41.3% females) of median age 18 years (interquartile range 7-30). Depending on the site, between 31% and 77.5% reported having experienced at least one violent event in Syria, 24.8-57.5% during the journey to Greece, and 5-8% in their Greek settlement. Over 75% (up to 92%) of respondents ≥15 years screened positive for anxiety disorder, which warranted referral for mental health evaluation, which was only accepted by 69-82% of participants. Access to legal information and assistance about asylum procedures were considered poor to non-existent for the majority, and the uncertainty of their status exacerbated their anxiety., Conclusions: This survey, conducted during a mass refugee crisis in a European Community country, provides important data on experiences in different refugee settings and reports the high levels of violence experienced by Syrian refugees during their journeys, the high prevalence of anxiety disorders, and the shortcomings of the international protective response.
- Published
- 2018
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31. Single-Dose Cholera Vaccine in Response to an Outbreak in Zambia.
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Ferreras E, Chizema-Kawesha E, Blake A, Chewe O, Mwaba J, Zulu G, Poncin M, Rakesh A, Page AL, Stoitsova S, Voute C, Uzzeni F, Robert H, Serafini M, Matapo B, Eiros JM, Quilici ML, Pezzoli L, Azman AS, Cohuet S, Ciglenecki I, Malama K, and Luquero FJ
- Subjects
- Case-Control Studies, Cholera epidemiology, Humans, Zambia epidemiology, Cholera prevention & control, Cholera Vaccines administration & dosage, Disease Outbreaks
- Published
- 2018
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32. Quantitative survey on health and violence endured by refugees during their journey and in Calais, France.
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Bouhenia M, Farhat JB, Coldiron ME, Abdallah S, Visentin D, Neuman M, Berthelot M, Porten K, and Cohuet S
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- Adult, Cross-Sectional Studies, Europe, Female, France, Humans, Male, Retrospective Studies, Surveys and Questionnaires, Young Adult, Health Status, Refugees statistics & numerical data, Violence statistics & numerical data
- Abstract
Background: In 2015, more than 1 million refugees arrived in Europe. During their travels, refugees often face harsh conditions, violence and torture in transit countries, but there is a lack of quantitative evidence on their experiences. We present the results of a retrospective survey among refugees in the 'Jungle' of Calais, France, to document their health problems and the violence they endured during their journeys., Methods: We conducted a cross-sectional population-based survey in November and December 2015. The sample size was set at 402 individuals, and geospatial simple random sampling was used. We collected data on demographics, routes travelled, health status, violence and future plans., Results: Departures from the country of origin increased beginning in September 2015. Sixty-one percent of respondents reported having at least one health problem, especially while in Calais. Overall, 65.6% (95% CI 60.3-70.6) experienced at least one violent event en route; 81.5% of refugees wanted to go to the UK., Conclusions: This first quantitative survey conducted among refugees in Europe provides important socio-demographic data on refugees living in Calais and describes the high rate of violence they encountered during their journeys. Similar documentation should be repeated throughout Europe in order to better respond to the needs of this vulnerable population., (© The Author 2017. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.)
- Published
- 2017
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33. Carriage prevalence and serotype distribution of Streptococcus pneumoniae prior to 10-valent pneumococcal vaccine introduction: A population-based cross-sectional study in South Western Uganda, 2014.
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Nackers F, Cohuet S, le Polain de Waroux O, Langendorf C, Nyehangane D, Ndazima D, Nanjebe D, Karani A, Tumwesigye E, Mwanga-Amumpaire J, Scott JAG, and Grais RF
- Subjects
- Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Infant, Infant, Newborn, Male, Pneumococcal Infections immunology, Pneumococcal Infections prevention & control, Pneumococcal Vaccines immunology, Prevalence, Serogroup, Streptococcus pneumoniae immunology, Uganda epidemiology, Vaccines, Conjugate immunology, Vaccines, Conjugate therapeutic use, Pneumococcal Vaccines therapeutic use, Streptococcus pneumoniae pathogenicity
- Abstract
Background: Information on Streptococcus pneumoniae nasopharyngeal (NP) carriage before the pneumococcal conjugate vaccine (PCV) introduction is essential to monitor impact. The 10-valent PCV (PCV10) was officially introduced throughout Ugandan national childhood immunization programs in 2013 and rolled-out countrywide during 2014. We aimed to measure the age-specific Streptococcus pneumoniae carriage and serotype distribution across all population age groups in the pre-PCV10 era in South Western Uganda., Methods: We conducted a two-stage cluster, age-stratified, cross-sectional community-based study in Sheema North sub-district between January and March 2014. One NP swab was collected and analyzed for each participant in accordance with World Health Organization guidelines., Results: NP carriage of any pneumococcal serotype was higher among children <2years old (77%; n=387) than among participants aged ≥15years (8.5%; n=325) (chi
2 p<0.001). Of the 623 positive cultures, we identified 49 serotypes among 610 (97.9%) isolates; thirteen (2.1%) isolates were non-typeable. Among <2years old, serotypes 6A, 6B, 14, 15B, 19F and 23F accounted for half of all carriers. Carriage prevalence with PCV10 serotypes was 29.4% among individuals aged <2years (n=387), 23.4% in children aged 2-4years (n=217), 11.4% in 5-14years (n=417), and 0.4% among individuals ≥15years of age (n=325). The proportion of carried pneumococci serotypes contained in PCV10 was 38.1% (n=291), 32.8% (n=154), 29.4% (n=156), and 4.4% (n=22) among carriers aged <2years, 2-4years, 5-14years and ≥15years, respectively., Discussion: In Sheema district, the proportion of PCV10 serotypes was low (<40%), across all age groups, especially among individuals aged 15years or older (<5%). PCV10 introduction is likely to impact transmission among children and to older individuals, but less likely to substantially modify pneumococcal NP ecology among individuals aged 15years or older., (Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.)- Published
- 2017
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34. Cholera Rapid Test with Enrichment Step Has Diagnostic Performance Equivalent to Culture.
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Ontweka LN, Deng LO, Rauzier J, Debes AK, Tadesse F, Parker LA, Wamala JF, Bior BK, Lasuba M, But AB, Grandesso F, Jamet C, Cohuet S, Ciglenecki I, Serafini M, Sack DA, Quilici ML, Azman AS, Luquero FJ, and Page AL
- Subjects
- Adult, Bacterial Typing Techniques, Cholera epidemiology, Disease Outbreaks, Female, Humans, Male, Molecular Typing, Population Surveillance, Prospective Studies, Reagent Kits, Diagnostic, Sensitivity and Specificity, South Sudan epidemiology, Vibrio cholerae genetics, Bacteriological Techniques methods, Cholera diagnosis, Diagnostic Tests, Routine methods, Feces microbiology, Vibrio cholerae isolation & purification
- Abstract
Cholera rapid diagnostic tests (RDT) could play a central role in outbreak detection and surveillance in low-resource settings, but their modest performance has hindered their broad adoption. The addition of an enrichment step may improve test specificity. We describe the results of a prospective diagnostic evaluation of the Crystal VC RDT (Span Diagnostics, India) with enrichment step and of culture, each compared to polymerase chain reaction (PCR), during a cholera outbreak in South Sudan. RDTs were performed on alkaline peptone water inoculated with stool and incubated for 4-6 hours at ambient temperature. Cholera culture was performed from wet filter paper inoculated with stool. Molecular detection of Vibrio cholerae O1 by PCR was done from dry Whatman 903 filter papers inoculated with stool, and from wet filter paper supernatant. In August and September 2015, 101 consecutive suspected cholera cases were enrolled, of which 36 were confirmed by PCR. The enriched RDT had 86.1% (95% CI: 70.5-95.3) sensitivity and 100% (95% CI: 94.4-100) specificity compared to PCR as the reference standard. The sensitivity of culture versus PCR was 83.3% (95% CI: 67.2-93.6) for culture performed on site and 72.2% (95% CI: 54.8-85.8) at the international reference laboratory, where samples were tested after an average delay of two months after sample collection, and specificity was 98.5% (95% CI: 91.7-100) and 100% (95% CI: 94.5-100), respectively. The RDT with enrichment showed performance comparable to that of culture and could be a sustainable alternative to culture confirmation where laboratory capacity is limited., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2016
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35. Effectiveness of one dose of oral cholera vaccine in response to an outbreak: a case-cohort study.
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Azman AS, Parker LA, Rumunu J, Tadesse F, Grandesso F, Deng LL, Lino RL, Bior BK, Lasuba M, Page AL, Ontweka L, Llosa AE, Cohuet S, Pezzoli L, Sodjinou DV, Abubakar A, Debes AK, Mpairwe AM, Wamala JF, Jamet C, Lessler J, Sack DA, Quilici ML, Ciglenecki I, and Luquero FJ
- Subjects
- Administration, Oral, Adolescent, Adult, Child, Child, Preschool, Cholera epidemiology, Cholera immunology, Cholera microbiology, Cohort Studies, Drug Administration Schedule, Female, Humans, India, Male, Middle Aged, Young Adult, Cholera therapy, Cholera Vaccines administration & dosage, Disease Outbreaks, Vaccination methods, Vibrio cholerae O1
- Abstract
Background: Oral cholera vaccines represent a new effective tool to fight cholera and are licensed as two-dose regimens with 2-4 weeks between doses. Evidence from previous studies suggests that a single dose of oral cholera vaccine might provide substantial direct protection against cholera. During a cholera outbreak in May, 2015, in Juba, South Sudan, the Ministry of Health, Médecins Sans Frontières, and partners engaged in the first field deployment of a single dose of oral cholera vaccine to enhance the outbreak response. We did a vaccine effectiveness study in conjunction with this large public health intervention., Methods: We did a case-cohort study, combining information on the vaccination status and disease outcomes from a random cohort recruited from throughout the city of Juba with that from all the cases detected. Eligible cases were those aged 1 year or older on the first day of the vaccination campaign who sought care for diarrhoea at all three cholera treatment centres and seven rehydration posts throughout Juba. Confirmed cases were suspected cases who tested positive to PCR for Vibrio cholerae O1. We estimated the short-term protection (direct and indirect) conferred by one dose of cholera vaccine (Shanchol, Shantha Biotechnics, Hyderabad, India)., Findings: Between Aug 9, 2015, and Sept 29, 2015, we enrolled 87 individuals with suspected cholera, and an 898-person cohort from throughout Juba. Of the 87 individuals with suspected cholera, 34 were classified as cholera positive, 52 as cholera negative, and one had indeterminate results. Of the 858 cohort members who completed a follow-up visit, none developed clinical cholera during follow-up. The unadjusted single-dose vaccine effectiveness was 80·2% (95% CI 61·5-100·0) and after adjusting for potential confounders was 87·3% (70·2-100·0)., Interpretation: One dose of Shanchol was effective in preventing medically attended cholera in this study. These results support the use of a single-dose strategy in outbreaks in similar epidemiological settings., Funding: Médecins Sans Frontières., (Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2016
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36. Intra-household use and acceptability of Ready-to-Use-Supplementary-Foods distributed in Niger between July and December 2010.
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Cohuet S, Marquer C, Shepherd S, Captier V, Langendorf C, Ale F, Phelan K, Manzo ML, and Grais RF
- Subjects
- Adolescent, Adult, Caregivers, Child, Child, Preschool, Cross-Sectional Studies, Culture, Dietary Supplements, Female, Focus Groups, Humans, Infant, Interpersonal Relations, Interviews as Topic, Male, Middle Aged, Niger, Perception, Social Values, Surveys and Questionnaires, Young Adult, Diet, Family Characteristics, Fast Foods statistics & numerical data, Malnutrition prevention & control, Patient Acceptance of Health Care, Social Behavior
- Abstract
Few studies have looked at consumption of Ready-to-Use-Supplementary-Foods (RUSFs) during a nutritional emergency. Here, we describe the use and acceptability of RUSF within households in four districts of the region of Maradi, Niger during large scale preventive distributions with RUSF in 2010 targeted at children 6-35months of age. Our study comprised both quantitative and qualitative components to collect detailed information and to allow in-depth interviews. We performed a cross-sectional survey in 16 villages between two monthly distributions of RUSF (October-November 2010). All households with at least one child who received RUSF were included and a total of 1842 caregivers were interviewed using a structured questionnaire. Focus groups and individual interviews of 128 caregivers were conducted in eight of the selected villages. On average, 24.7% of households reported any sharing of RUSF within the household. Sharing practices outside the household remained rare. Most of the sharing reported occurred among children under 5years of age living in the household. On average, 91% of caregivers in all districts rated the child's appreciation of the products as good or very good. Program planning may need to explicitly accounting for the sharing of products among children under 5 within household., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2012
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37. Prevalence of and risks for internal contamination among hospital staff caring for a patient contaminated with a fatal dose of polonium-210.
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le Polain de Waroux O, Cohuet S, Bishop L, Johnson S, Shaw K, Maguire H, Charlett A, and Fraser G
- Subjects
- Acute Radiation Syndrome blood, Acute Radiation Syndrome etiology, Acute Radiation Syndrome urine, Adult, Fatal Outcome, Female, Humans, Interviews as Topic, Male, Middle Aged, Poisson Distribution, Polonium administration & dosage, Polonium urine, Prevalence, Radioactive Hazard Release prevention & control, Risk Assessment, Risk Factors, Occupational Exposure prevention & control, Personnel, Hospital, Polonium poisoning, Protective Devices statistics & numerical data, Radiation Injuries prevention & control, Radiation Protection methods, Radiation Protection statistics & numerical data
- Abstract
Background: Alexander Litvinenko died on November 23, 2006, from acute radiation sickness syndrome caused by ingestion of polonium-210 (²¹⁰Po)., Objective: The objective was to assess the prevalence of and risk factors for internal contamination with ²¹⁰Po in healthcare workers (HCWs) caring for the contaminated patient., Setting: Hospital., Participants: HCWs who had direct contact with the patient., Methods: We interviewed 43 HCWs and enquired about their activities and use of personal protective equipment (PPE). Internal contamination was defined as urinary ²¹⁰Po excretion above 20 mBq within 24 hours. We obtained risk ratios (RRs) for internal contamination using Poisson regression., Results: Thirty-seven HCWs (86%) responded, and 8 (22%) showed evidence of internal contamination, all at very low levels that were unlikely to cause adverse health outcomes. Daily care of the patient (washing and toileting the patient) was the main risk factor (RR, 3.6 [95% confidence interval (CI), 1.1-11.6]). In contrast, planned invasive procedures were not associated with a higher risk. There was some evidence of a higher risk associated with handling blood samples (RR, 3.5 [95% CI, 0.8-15.6]) and changing urine bags and/or collecting urine samples (RR, 2.7 [95% CI, 0.8-9.5]). There was also some evidence that those who reported not always using standard PPE were at higher risk than were others (RR, 2.5 [95% CI, 0.8-8.1])., Conclusions: The sensitive quantitative measurement enabled us to identify factors associated with contamination, which by analogy to other conditions with similar transmission mechanisms may help improve protection and preparedness in staff dealing with an ill patient who experiences an unknown illness.
- Published
- 2011
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38. [Malaria in France: Mainland and territories].
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Tarantola A, Eltges F, Ardillon V, Lernout T, Sissoko D, Kendjo E, Achirafi A, Thiria J, Flamand C, D'Ortenzio E, Cohuet S, Quatresous I, Quenel P, Filleul L, and Gastellu-Etchegorry M
- Subjects
- Africa, Animals, Anopheles parasitology, Antimalarials therapeutic use, Comoros epidemiology, Emigration and Immigration, Endemic Diseases, Female, France epidemiology, French Guiana epidemiology, Humans, Incidence, Insect Bites and Stings parasitology, Insect Vectors parasitology, Insecticide-Treated Bednets, Malaria drug therapy, Malaria prevention & control, Malaria transmission, Male, Mosquito Control, Pregnancy, Pregnancy Complications, Parasitic epidemiology, Pregnancy Complications, Parasitic prevention & control, Reunion epidemiology, Travel, West Indies epidemiology, Malaria epidemiology
- Abstract
Malaria, which was eliminated first from Metropolitan France (mainland and Corsica), then in the French West Indies and the Reunion Island during the 20(th) century, remains endemic in two French territories: French Guiana and the Indian Ocean Mayotte island. Despite differences in the dominating plasmodial species and epidemiological patterns, these two territories have achieved marked quantitative improvements (in the reported number of cases and severe cases) thanks to efforts undertaken over the past decade. The situation, however, remains a concern from a qualitative standpoint with the emergence of resistance to antimalarial drugs and logistical and administrative issues which hinder access to treatment. Although malaria was eradicated in Metropolitan France half a century ago, competent vectors remain present in part or all of these territories and can give rise to limited outbreaks., (Copyright © 2011 Elsevier Masson SAS. All rights reserved.)
- Published
- 2011
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39. Profound and sustained reduction in Chlamydia trachomatis in The Gambia: a five-year longitudinal study of trachoma endemic communities.
- Author
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Burton MJ, Holland MJ, Makalo P, Aryee EA, Sillah A, Cohuet S, Natividad A, Alexander ND, Mabey DC, and Bailey RL
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Bacteriological Techniques, Child, Child, Preschool, Endemic Diseases, Female, Gambia epidemiology, Humans, Infant, Infant, Newborn, Longitudinal Studies, Male, Middle Aged, Polymerase Chain Reaction methods, Prevalence, Trachoma microbiology, Young Adult, Anti-Bacterial Agents administration & dosage, Chlamydia trachomatis isolation & purification, Trachoma drug therapy, Trachoma epidemiology
- Abstract
Background: The elimination of blinding trachoma focuses on controlling Chlamydia trachomatis infection through mass antibiotic treatment and measures to limit transmission. As the prevalence of disease declines, uncertainty increases over the most effective strategy for treatment. There are little long-term data on the effect of treatment on infection, especially in low prevalence settings, on which to base guidelines., Methodology/principal Findings: The population of a cluster of 14 Gambian villages with endemic trachoma was examined on seven occasions over five years (baseline, 2, 6, 12, 17, 30 and 60 months). Mass antibiotic treatment was given at baseline only. All families had accessible clean water all year round. New latrines were installed in each household after 17 months. Conjunctival swab samples were collected and tested for C. trachomatis by PCR. Before treatment the village-level prevalence of follicular trachoma in 1 to 9 year olds (TF(%1-9)) was 15.4% and C. trachomatis was 9.7%. Antibiotic treatment coverage was 83% of the population. In 12 villages all baseline infection cleared and few sporadic cases were detected during the following five years. In the other two villages treatment was followed by increased infection at two months, which was associated with extensive contact with other untreated communities. The prevalence of infection subsequently dropped to 0% in these 2 villages and 0.6% for the whole population by the end of the study in the absence of any further antibiotic treatment. However, several villages had a TF(%1-9) of >10%, the threshold for initiating or continuing mass antibiotic treatment, in the absence of any detectable C. trachomatis., Conclusions/significance: A single round of mass antibiotic treatment may be sufficient in low prevalence settings to control C. trachomatis infection when combined with environmental conditions, which suppress transmission, such as a good water supply and sanitation.
- Published
- 2010
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40. Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis.
- Author
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Zwang J, Olliaro P, Barennes H, Bonnet M, Brasseur P, Bukirwa H, Cohuet S, D'Alessandro U, Djimdé A, Karema C, Guthmann JP, Hamour S, Ndiaye JL, Mårtensson A, Rwagacondo C, Sagara I, Same-Ekobo A, Sirima SB, van den Broek I, Yeka A, Taylor WR, Dorsey G, and Randrianarivelojosia M
- Subjects
- Adolescent, Adult, Africa South of the Sahara, Aged, Aged, 80 and over, Animals, Child, Child, Preschool, Drug Combinations, Female, Humans, Infant, Male, Middle Aged, Plasmodium falciparum isolation & purification, Treatment Outcome, Young Adult, Amodiaquine therapeutic use, Antimalarials therapeutic use, Artemisinins therapeutic use, Malaria, Falciparum drug therapy
- Abstract
Background: Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the efficacy of ACT, recently adopted by the World Health Organization (WHO) and deployed over 80 countries, in order to make an evidence-based drug policy., Methods: An individual patient data (IPD) analysis was conducted on efficacy outcomes in 26 clinical studies in sub-Saharan Africa using the WHO protocol with similar primary and secondary endpoints., Results: A total of 11,700 patients (75% under 5 years old), from 33 different sites in 16 countries were followed for 28 days. Loss to follow-up was 4.9% (575/11,700). AS&AQ was given to 5,897 patients. Of these, 82% (4,826/5,897) were included in randomized comparative trials with polymerase chain reaction (PCR) genotyping results and compared to 5,413 patients (half receiving an ACT). AS&AQ and other ACT comparators resulted in rapid clearance of fever and parasitaemia, superior to non-ACT. Using survival analysis on a modified intent-to-treat population, the Day 28 PCR-adjusted efficacy of AS&AQ was greater than 90% (the WHO cut-off) in 11/16 countries. In randomized comparative trials (n = 22), the crude efficacy of AS&AQ was 75.9% (95% CI 74.6-77.1) and the PCR-adjusted efficacy was 93.9% (95% CI 93.2-94.5). The risk (weighted by site) of failure PCR-adjusted of AS&AQ was significantly inferior to non-ACT, superior to dihydroartemisinin-piperaquine (DP, in one Ugandan site), and not different from AS+SP or AL (artemether-lumefantrine). The risk of gametocyte appearance and the carriage rate of AS&AQ was only greater in one Ugandan site compared to AL and DP, and lower compared to non-ACT (p = 0.001, for all comparisons). Anaemia recovery was not different than comparator groups, except in one site in Rwanda where the patients in the DP group had a slower recovery., Conclusion: AS&AQ compares well to other treatments and meets the WHO efficacy criteria for use against falciparum malaria in many, but not all, the sub-Saharan African countries where it was studied. Efficacy varies between and within countries. An IPD analysis can inform general and local treatment policies. Ongoing monitoring evaluation is required.
- Published
- 2009
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41. Factors associated with incomplete vaccination of babies at risk of perinatal hepatitis B transmission: a London study in 2006.
- Author
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Giraudon I, Permalloo N, Nixon G, Charlett A, Cohuet S, Mandal S, Ramsay M, Patel BC, and Maguire H
- Subjects
- Adolescent, Adult, Cohort Studies, Female, Hepatitis Antibodies administration & dosage, Hepatitis Antibodies blood, Hepatitis B blood, Hepatitis B transmission, Hepatitis B Surface Antigens blood, Hepatitis B Surface Antigens immunology, Hepatitis B Vaccines immunology, Humans, Immunoglobulin G administration & dosage, Infant, London, Middle Aged, Pregnancy, Pregnancy Complications, Infectious blood, Retrospective Studies, Surveys and Questionnaires, Young Adult, Hepatitis B prevention & control, Hepatitis B Vaccines administration & dosage, Infectious Disease Transmission, Vertical prevention & control, Pregnancy Complications, Infectious prevention & control, Vaccination
- Abstract
We measured the hepatitis B (HB) vaccination uptake in 249 London babies born in 2004 to HBsAg positive mothers. Two thirds (69%) received three vaccinations and half (49%, 95% CI 43-56) received a complete course (four doses). Complete immunization was associated with sector of delivery (p<0.001), recording of the GP details in case notes, having booked for antenatal care, having a good command of English, and receipt of written information on HB. A third of the babies (33%) had a post-vaccination test; when the mother had other children, 39% of the oldest children were vaccinated; information on partner's vaccination was available for 12%. This study highlights that appropriate counseling and information should be provided to the mothers, and the importance in London of arrangements for integrated care across acute and primary care services.
- Published
- 2009
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42. Community coverage of an antimalarial combination of artesunate and amodiaquine in Makamba Province, Burundi, nine months after its introduction.
- Author
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Gerstl S, Cohuet S, Edoh K, Brasher C, Lesage A, Guthmann JP, and Checchi F
- Subjects
- Artesunate, Burundi epidemiology, Child, Preschool, Community Health Services economics, Community Health Services methods, Cross-Sectional Studies, Drug Therapy, Combination, Fever etiology, Humans, Infant, Infant, Newborn, Malaria complications, Malaria epidemiology, Amodiaquine therapeutic use, Antimalarials therapeutic use, Artemisinins therapeutic use, Malaria drug therapy, Sesquiterpenes therapeutic use
- Abstract
Background: In 2003, artesunate-amodiaquine (AS+AQ) was introduced as the new first-line treatment for uncomplicated malaria in Burundi. After confirmed diagnosis, treatment was delivered at subsidized prices in public health centres. Nine months after its implementation a study was carried out to assess whether children below five years of age with uncomplicated malaria were actually receiving AS+AQ., Methods: A community-based study was conducted in Makamba province. Randomly selected households containing one or more children under five with reported fever onset within fourteen days before the study date were eligible. Case-management information was collected based on caregiver recall. A case definition of symptomatic malaria from observations of children presenting a confirmed malaria episode on the day of the survey was developed. Based on this definition, those children who had probable malaria among those with fever onset in the 14 days prior to the study were identified retrospectively. Treatment coverage with AS+AQ was then estimated among these probable malaria cases., Results: Out of 195 children with fever on the day of the study, 92 were confirmed as true malaria cases and 103 tested negative. The combination of 'loss of appetite', 'sweating', 'shivering' and 'intermittent fever' yielded the highest possible positive predictive value, and was chosen as the case definition of malaria. Out of 526 children who had had fever 14 days prior to the survey, 165 (31.4%) were defined as probable malaria cases using this definition. Among them, 20 (14.1%) had been treated with AS+AQ, 10 with quinine (5%), 68 (41%) received non-malaria treatments, and 67 got traditional treatment or nothing (39.9%). Most people sought treatment from public health centres (23/99) followed by private clinics (15/99, 14.1%). The median price paid for AS+AQ was 0.5 US$., Conclusion: AS+AQ was the most common treatment for patients with probable malaria at public health centres, but coverage was low due to low health centre utilisation and apparently inappropriate prescribing. In addition, AS+AQ was given to patients at a price ten times higher than the subsidized price. The availability and proper use of ACTs should be monitored and maximized after their introduction in order to have a significant impact on the burden of malaria.
- Published
- 2007
- Full Text
- View/download PDF
43. Outbreak of measles among Irish Travellers in England, March to May 2007.
- Author
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Cohuet S, Morgan O, Bukasa A, Heathcock R, White J, Brown K, Ramsay M, and Gross R
- Subjects
- Adolescent, Adult, Child, Child, Preschool, England epidemiology, Female, Humans, Infant, Ireland ethnology, Male, Population Surveillance, Disease Outbreaks prevention & control, Measles epidemiology, Travel statistics & numerical data
- Published
- 2007
- Full Text
- View/download PDF
44. Short report: molecular markers associated with Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in the Democratic Republic of Congo.
- Author
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Cohuet S, Bonnet M, Van Herp M, Van Overmeir C, D'Alessandro U, and Guthmann JP
- Subjects
- Animals, Codon genetics, Democratic Republic of the Congo, Drug Combinations, Drug Resistance genetics, Genetic Markers, Genotype, Humans, Mutation genetics, Polymerase Chain Reaction methods, Prevalence, Antimalarials pharmacology, Dihydropteroate Synthase genetics, Plasmodium falciparum drug effects, Plasmodium falciparum genetics, Pyrimethamine pharmacology, Sulfadoxine pharmacology, Tetrahydrofolate Dehydrogenase genetics
- Abstract
Sulfadoxine-pyrimethamine (SP) is the first line antimalarial treatment in the Democratic Republic of Congo. Using polymerase chain reaction, we assessed the prevalence of mutations in the dihydrofolate reductase (dhfr) (codons 108, 51, 59) and dihydropteroate synthase (dhps) (codons 437, 540) genes of Plasmodium falciparum, which have been associated with resistance to pyrimethamine and sulfadoxine, respectively. Four hundred seventy-four patients were sampled in Kilwa (N = 138), Kisangani (N = 112), Boende (N = 106), and Basankusu (N = 118). The proportion of triple mutations dhfr varied between sites but was always > 50%. The proportion of dhps double mutations was < 20%, with some sites as low as 0.9%. A quintuple mutation was present in 12.8% (16/125) samples in Kilwa; 11.9% (13/109) in Kisangani, 2.9% (3/102) in Boende, and 0.9% (1/112) in Basankusu. These results suggest high resistance to pyrimethamine alone or combined with sulfadoxine. Adding artesunate to SP does not seem a valid alternative to the current monotherapy.
- Published
- 2006
45. High efficacy of two artemisinin-based combinations (artesunate + amodiaquine and artemether + lumefantrine) in Caala, Central Angola.
- Author
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Guthmann JP, Cohuet S, Rigutto C, Fortes F, Saraiva N, Kiguli J, Kyomuhendo J, Francis M, Noël F, Mulemba M, and Balkan S
- Subjects
- Amodiaquine administration & dosage, Amodiaquine pharmacology, Angola, Animals, Antimalarials pharmacology, Antimalarials standards, Artemether, Artemisinins pharmacology, Artesunate, Child, Preschool, Drug Therapy, Combination, Ethanolamines administration & dosage, Ethanolamines pharmacology, Female, Fluorenes administration & dosage, Fluorenes pharmacology, Humans, Infant, Lumefantrine, Male, Sesquiterpenes administration & dosage, Sesquiterpenes pharmacology, Treatment Outcome, Antimalarials administration & dosage, Artemisinins administration & dosage, Malaria, Falciparum drug therapy
- Abstract
In April 2004, 137 children 6-59 months of age with uncomplicated Plasmodium falciparum (Pf) malaria (Caala, Central Angola) were randomized to receive either artemether-lumefantrine (Coartem) or artesunate + amodiaquine (ASAQ). After 28 days of follow-up, there were 2/61 (3.2%) recurrent parasitemias in the Coartem group and 4/64 (6.2%) in the ASAQ group (P = 0.72), all classified as re-infections after PCR genotyping (cure rate = 100% [95%CI: 94-100] in both groups). Only one patient (ASAQ group) had gametocytes on day 28 versus five (Coartem) and three (ASAQ) at baseline. Compared with baseline, anemia was significantly improved after 28 days of follow-up in both groups (Coartem: from 54.1% to 13.4%; ASAQ: from 53.1% to 15.9%). Our findings are in favor of a high efficacy of both combinations in Caala. Now that Coartem has been chosen as the new first-line anti-malarial, the challenge is to insure that this drug is available and adequately used.
- Published
- 2006
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