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5. A FAIENCE HEAD OF A BEARDED MALE FROM TEL ABEL BETH MAACAH: ICONOGRAPHY, TECHNOLOGY AND CONTEXT.

Author

Yahalom‐Mack, N., Ben‐Ami, D.V., Panitz‐Cohen, N., Mullins, R.A., Brumfeld, V., and Eliyahu‐Behar, A.

Subjects
BEARDS, RELIGIOUS idols, MALES
Abstract

Summary: A faience head depicting a bearded male was unearthed in a ninth‐century BC context at Tel Abel Beth Maacah, located on the modern Israel‐Lebanese border. During the Iron Age, the site was at the interface between the kingdoms of Israel and Aram‐Damascus and the Phoenician city‐states of Tyre and Sidon. The article discusses the object's iconography, style, composition and manufacturing technology in comparison to other faience heads, as well as its regional and contextual significance. Despite its unique iconography and high quality, we demonstrate its similarity to at least one other head in manufacturing technology and style. It is suggested that it depicts an ideal elite persona, possibly serving as a votive. [ABSTRACT FROM AUTHOR]

Published
2024
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15. DOP79 Promising efficacy of biologicals and small molecules for microscopic colitis: results from a large real-life multicenter cohort

Author

Verstockt ., B, primary, Taelman, T, additional, Vavricka, S R, additional, Zabana, Y, additional, Lenfant, M, additional, Macaigne, G, additional, Maillard, M H, additional, Savarino, E, additional, Teich, N, additional, Kiudelis, V, additional, de la Revilla Negro, J, additional, Ribaldone, D G, additional, Barreiro-de Acosta, M, additional, Wildt, S, additional, Rivière, P, additional, Fumery, M, additional, Truyens, M, additional, Amiot, A, additional, Marsal, J, additional, Levartovsky, A, additional, Vieujean, S, additional, Somers, M, additional, Cremer, A, additional, Lutakov, I, additional, Cohen, N A, additional, Dewit, S, additional, Bajer, L, additional, Rahier, J F, additional, Backman, A S, additional, Nancey, S, additional, Choden, T, additional, Van Dongen, J, additional, Münch, A, additional, and Julsgaard, M, additional

Published
2024
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17. P1203 Fecal transplantation for Ulcerative Colitis from diet conditioned donors followed by dietary intervention results in favorable gut microbial profile and decreased gut inflammation compared to fecal transplantation alone

Author

Leibovitzh, H, primary, Sarbagili Shabat, C, additional, Hirsch, A, additional, Zittan, E, additional, Mentella, M C, additional, Petito, V, additional, Cohen, N A, additional, Ron, Y, additional, Fliss Isakov, N, additional, Pfeffer, J, additional, Yaakov, M, additional, Fanali, C, additional, Turchini, L, additional, Masucci, L, additional, Quaranta, G, additional, Kolonimos, N, additional, Godneva, A, additional, Weinberger, A, additional, Scaldaferri, F, additional, and Maharshak, N, additional

Published
2024
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21. Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes

Author

Weiss, Lauren, Josowitz, R, Mulero-Navarro, S, Rodriguez, NA, Falce, C, Cohen, N, Ullian, EM, Rauen, KA, Sobie, EA, and Gelb, BD

Abstract

© 2016 The AuthorsGermline mutations in BRAF cause cardio-facio-cutaneous syndrome (CFCS), whereby 40% of patients develop hypertrophic cardiomyopathy (HCM). As the role of the RAS/MAPK pathway in HCM pathogenesis is unclear, we generated a human induced p

Published
2016

23. LBA4 Low-dose stereotactic body radiotherapy prior to pre-operative cemiplimab for patients with resectable hepatocellular carcinoma

Author

Marron, T.U., primary, Hapanowicz, O., additional, Lucas, N., additional, Wu, K., additional, Buckstein, M., additional, Tabrizian, P., additional, Taouli, B., additional, Kim, E., additional, Garcia-Reyes, K., additional, Fiel, M.I., additional, Ward, S., additional, Cohen, N., additional, Hiotis, S., additional, Thanigaimani, P., additional, Hao, Y., additional, Lowy, I., additional, Miller, E.A., additional, Uldrick, T.S., additional, Schwartz, M., additional, and Merad, M., additional

Published
2023
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25. Sheared stably stratified turbulence and large-scale waves in a lid driven cavity

Author

Cohen, N., Eidelman, A., Elperin, T., Kleeorin, N., and Rogachevskii, I.

Subjects
Physics - Fluid Dynamics, Astrophysics - Earth and Planetary Astrophysics
Abstract

We investigated experimentally stably stratified turbulent flows in a lid driven cavity with a non-zero vertical mean temperature gradient in order to identify the parameters governing the mean and turbulent flows and to understand their effects on the momentum and heat transfer. We found that the mean velocity patterns (e.g., the form and the sizes of the large-scale circulations) depend strongly on the degree of the temperature stratification. In the case of strong stable stratification, the strong turbulence region is located in the vicinity of the main large-scale circulation. We detected the large-scale nonlinear oscillations in the case of strong stable stratification which can be interpreted as nonlinear internal gravity waves. The ratio of the main energy-containing frequencies of these waves in velocity and temperature fields in the nonlinear stage is about 2. The amplitude of the waves increases in the region of weak turbulence (near the bottom wall of the cavity), whereby the vertical mean temperature gradient increases., Comment: 11 pages, 14 figures, REVTEX4-1

Published
2014
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27. Compound decision in the presence of proxies with an application to spatio-temporal data

Author

Cohen, N., Greenshtein, E., and Ritov, Y.

Subjects
Mathematics - Statistics Theory, Statistics - Methodology
Abstract

We study the problem of incorporating covariates in a compound decision setup. It is desired to estimate the means of $n$ response variables, which are independent and normally distributed, and each is accompanied by a vector of covariates. We suggest a method that involves non-parametric empirical Bayes techniques and may be viewed as a generalization of the celebrated Fay-Herriot (1979) method. Some optimality properties of our method are proved. We also compare it numerically with Fay-Herriot and other methods, using a `semi-real' data set that involves spatio-temporal covariates, where the goal is to estimate certain proportions in many small areas (Statistical-Areas)

Published
2010

28. The Visualization of the Road Coloring Algorithm in the package TESTAS

Author

Trahtman, A. N., Bauer, T., and Cohen, N.

Subjects
Computer Science - Discrete Mathematics, Computer Science - Formal Languages and Automata Theory
Abstract

A synchronizing word of a deterministic automaton is a word in the alphabet of colors of its edges that maps the automaton to a single state. A coloring of edges of a directed graph is synchronizing if the coloring turns the graph into a deterministic finite automaton possessing a synchronizing word. The road coloring problem is the problem of synchronizing coloring of a directed finite strongly connected graph with constant outdegree of all its vertices if the greatest common divisor of the lengths of all its cycles is one. A polynomial time algorithm of the road coloring has been based on recent positive solution of this old famous problem. One can use our new visualization program for demonstration of the algorithm as well as for visualization of the transition graph of any finite automaton. The visual image presents some structure properties of the transition graph. This help tool is linear in the size of the automaton., Comment: 12 pages

Published
2009

29. Erratum: Consortium biology in immunology: The perspective from the Immunological Genome Project

Author

Benoist, C, Lanier, L, Merad, M, Mathis, D, Ericson, J, Painter, M, Davis, S, Laplace, C, Hyatt, G, Paik, H, Rothamel, K, Cruse, R, Doran, G, Heng, T, Asinovski, N, Ortiz-Lopes, A, Ergun, A, Gray, D, Wakamatsu, E, Hill, J, Mingueneau, M, Cipolletta, D, Yoshida, H, Cohen, N, Kim, E, Brennan, P, Lynch, L, Brenner, M, Costello, J, Collins, JJ, Blair, D, Dustin, M, Knell, J, Yang, E, Best, A, Shaw, L, Doedens, A, Goldrath, A, Shinton, S, Zhou, Y, Hardy, R, Jojic, V, Mostafavi, S, Koller, D, Jianu, R, Laidlaw, D, Bezman, N, Sun, J, Zhu, Y, Hendricks, D, Kamimura, Y, Min-Oo, G, Morvan, M, Nabekura, T, Lam, V, Kim, C, Greter, M, Helft, J, Chow, A, Bogunovic, M, Mortha, A, Price, J, Hashimoto, D, Miller, J, Sathe, P, Chudnovskiy, A, Lavin, Y, Idoyaga, J, Gautier, E, Jakubzick, C, D'Angelo, J, Randolph, G, Shay, T, Regev, A, Gazit, R, Rossi, D, Kreslawsky, T, von Bohmer, H, Bellemare-Pelletier, A, Elpek, K, Spelv, L, Fletcher, A, Malhotra, D, Cremasco, V, Turley, S, Kim, F, Nageswara Rao, T, and Wagers, A

Subjects
Immunology
Published
2014

32. Consensus criteria for chronic rhinosinusitis disease control: an international Delphi Study

Author

Sedaghat, A R, primary, Fokkens, W J, additional, Lund, V J, additional, Hellings, P W, additional, Kern, R C, additional, Reitsma, S, additional, Toppila-Salmi, S, additional, Bernal- Sprekelsen, M, additional, Mullol, J, additional, Gevaert, P, additional, Teeling, T, additional, Alobid, I, additional, Anselmo-Lima, W T, additional, Baroody, F M, additional, Cervin, A, additional, Cohen, N A, additional, Constantinidis, J, additional, De Gabory, L, additional, Desrosiers, M, additional, Harvey, R J, additional, Kalogjera, L, additional, Knill, A, additional, Landis, B N, additional, Meco, C, additional, Philpott, C M, additional, Ryan, D, additional, Schlosser, R J, additional, Senior, B A, additional, Smith, T L, additional, Tomazic, P V, additional, Zhang, L, additional, and Hopkins, C, additional

Published
2023
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33. Very Short Answer Questions: A Novel Approach To Summative Assessments In Pathology

Author

Sam AH, Peleva E, Fung CY, Cohen N, Benbow EW, and Meeran K

Subjects
pathology, teaching, assessment, very short answer questions, Special aspects of education, LC8-6691, Medicine (General), R5-920
Abstract

Amir H Sam,1 Emilia Peleva,1 Chee Yeen Fung,1 Nicki Cohen,2 Emyr W Benbow,3 Karim Meeran1 1Imperial College School of Medicine, Imperial College London, London, UK; 2King’s College London, London, UK; 3University of Manchester, Manchester, UKCorrespondence: Karim MeeranDepartment of Endocrinology, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UKEmail k.meeran@imperial.ac.ukBackground: A solid understanding of the science underpinning treatment is essential for all doctors. Pathology teaching and assessment are fundamental components of the undergraduate medicine curriculum. Assessment drives learning and the choice of assessments influences students’ learning behaviours. The use of multiple-choice questions is common but is associated with significant cueing and may promote “rote learning”. Essay-type questions and Objective Structured Clinical Examinations (OSCEs) are resource-intensive in terms of delivery and marking and do not allow adequate sampling of the curriculum. To address these limitations, we used a novel online tool to administer Very Short Answer questions (VSAQs) and evaluated the utility of the VSAQs in an undergraduate summative pathology assessment.Methods: A group of 285 medical students took the summative assessment, comprising 50 VSAQs, 50 single best answer questions (SBAQs), and 75 extended matching questions (EMQs). The VSAQs were machine-marked against pre-approved responses and subsequently reviewed by a panel of pathologists, with the software remembering all new marking judgements.Results: The total time taken to mark all 50 VSAQs for all 285 students was 5 hours, compared to 70 hours required to manually mark an equivalent number of questions in a paper-based pathology exam. The median percentage score for the VSAQs test (72%) was significantly lower than that of the SBAQs (80%) and EMQs (84%), p

Published
2019

34. Quaternionic commutations

Author

Cohen, N., De Leo, S., and Ducati, G.

Subjects
Mathematics - Rings and Algebras, 11R52
Abstract

Given n quaternions we investigate the extent of non-commutativity of their multiple products, commutators and exponential products., Comment: 6 pages, no figures

Published
2003

35. Development and validation of novel algorithms to identify patients with inflammatory bowel diseases in Israel: an epi-IIRN group study

Author

Friedman MY, Leventer-Roberts M, Rosenblum J, Zigman N, Goren I, Mourad V, Lederman N, Cohen N, Matz E, Dushnitzky DZ, Borovsky N, Hoshen MB, Focht G, Avitzour M, Shachar Y, Chowers Y, Eliakim R, Ben-Horin S, Odes S, Schwartz D, Dotan I, Israeli E, Levi Z, Benchimol EI, Balicer RD, and Turner D

Subjects
Inflammatory Bowel Diseases, Crohn's disease, Ulcerative colitis, search algorithms, validation, case ascertainment, Israel, administrative database research., Infectious and parasitic diseases, RC109-216
Abstract

Mira Y Friedman,1,2 Maya Leventer-Roberts,3 Joseph Rosenblum,4 Nir Zigman,4 Iris Goren,4 Vered Mourad,4 Natan Lederman,5 Nurit Cohen,5 Eran Matz,6 Doron Z Dushnitzky,6 Nirit Borovsky,6 Moshe B Hoshen,3 Gili Focht,1 Malka Avitzour,1 Yael Shachar,1 Yehuda Chowers,7 Rami Eliakim,8 Shomron Ben-Horin,8 Shmuel Odes,9 Doron Schwartz,9 Iris Dotan,10 Eran Israeli,11 Zohar Levi,10 Eric I Benchimol,12–14 Ran D Balicer,3 Dan Turner1 On behalf of the Israeli IBD Research Nucleus (IIRN) 1The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel; 2Braun School of Public and Community Medicine, The Hebrew University – Hadassah Medical Center, Jerusalem, Israel; 3Clalit Research Institute, Chief’s Office, Clalit Health Services, Tel Aviv, Israel; 4Maccabi Healthcare Services, Tel Aviv, Israel; 5Meuhedet Health Services, Tel Aviv, Israel; 6Leumit Health Services, Tel Aviv, Israel; 7Department of Gastroenterology, Rambam Health Care Campus, Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel; 8Department of Gastroenterology, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; 9Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel; 10Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel; 11Institute of Gastroenterology and Liver Diseases, Hadassah Medical Center, Hebrew University, Jerusalem, Israel; 12CHEO Inflammatory Bowel Disease Centre, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada; 13Department of Pediatrics and School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, ON, Canada; 14Institute for Clinical Evaluative Sciences, Ottawa, ON, Canada Background: Before embarking on administrative research, validated case ascertainment algorithms must be developed. We aimed at developing algorithms for identifying inflammatory bowel disease (IBD) patients, date of disease onset, and IBD type (Crohn’s disease [CD] vs ulcerative colitis [UC]) in the databases of the four Israeli Health Maintenance Organizations (HMOs) covering 98% of the population. Methods: Algorithms were developed on 5,131 IBD patients and 2,072 controls, following independent chart review (60% CD and 39% UC). We reviewed 942 different combinations of clinical parameters aided by mathematical modeling. The algorithms were validated on an independent cohort of 160,000 random subjects. Results: The combination of the following variables achieved the highest diagnostic accuracy: IBD-related codes, alone if more than five to six codes or combined with purchases of IBD-related medications (at least three purchases or ≥3 months from the first to last purchase) (sensitivity 89%, specificity 99%, positive predictive value [PPV] 92%, negative predictive value [NPV] 99%). A look-back period of 2–5 years (depending on the HMO) without IBD-related codes or medications best determined the date of diagnosis (sensitivity 83%, specificity 68%, PPV 82%, NPV 70%). IBD type was determined by the majority of CD/UC codes of the three recent contacts or the most recent when less than three contacts were recorded (sensitivity 92%, specificity 97%, PPV 97%, NPV 92%). Applying these algorithms, a total of 38,291 IBD patients were residing in Israel, corresponding to a prevalence rate of 459/100,000 (0.46%). Conclusion: The application of the validated algorithms to Israel’s administrative databases will now create a large and accurate ongoing population-based cohort of IBD patients for future administrative studies. Keywords: inflammatory bowel diseases, Crohn’s disease, ulcerative colitis, search algorithms, validation, case ascertainment, Israel, administrative database research

Published
2018

36. MicroRNA–mRNA expression profiles associated with medulloblastoma subgroup 4

Author

Gershanov S, Toledano H, Michowiz S, Barinfeld O, Pinhasov A, Goldenberg-Cohen N, and Salmon-Divon M

Subjects
RNA-seq, Pediatric brain tumor, Differential expression, Tumor subgroups, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Sivan Gershanov,1 Helen Toledano,2,3 Shalom Michowiz,3,4 Orit Barinfeld,3,5 Albert Pinhasov,1 Nitza Goldenberg-Cohen,5–7 Mali Salmon-Divon1 1Genomic Bioinformatics Laboratory, Department of Molecular Biology, Ariel University, Ariel, Israel; 2Department of Pediatric Oncology, Schneider Children’s Medical Center of Israel, Petah Tikva, Israel; 3Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 4Department of Pediatric Neurosurgery, Schneider Children’s Medical Center of Israel, Petah Tikva, Israel; 5The Krieger Eye Research Laboratory, Felsenstein Medical Research Center, Beilinson Hospital, Petah Tikva, Tel Aviv, Israel; 6Department of Ophthalmology, Bnai Zion Medical Center, Haifa, Israel; 7The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel Purpose: Medulloblastoma (MB), the most common malignant brain tumor in children, is divided into four tumor subgroups: wingless-type (WNT), sonic hedgehog (SHH), Group 3, and Group 4. ­Ideally, clinical practice and treatment design should be subgroup specific. While WNT and SHH subgroups have well-defined biomarkers, distinguishing Group 3 from Group 4 is not straightforward. MicroRNAs (miRNAs), which regulate posttranscriptional gene expression, are involved in MB tumorigenesis. However, the miRNA–messenger RNA (mRNA) regulatory network in MB is far from being fully understood. Our aims were to investigate miRNA expression regulation in MB subgroups, to assess miRNA target relationships, and to identify miRNAs that can distinguish Group 3 from Group 4. Patients and methods: With these aims, integrated transcriptome mRNA and miRNA expression analysis was performed on primary tumor samples collected from 18 children with MB, using miRNA sequencing (miRNA-seq), RNA sequencing (RNA-seq), and quantitative PCR. Results: Of all the expressed miRNAs, 19 appeared to be significantly differentially expressed (DE) between Group 4 and non-Group 4 subgroups (false discovery rate [FDR]

Published
2018

37. Different shadows : gay representation in Israeli cinema

Author

Cohen, N.

Subjects
791.43
Abstract

Different Shadows: Gay Representation in Israeli Cinema studies the role of cinema in the rise of Israeli gay consciousness over the past three decades. One aim of this research is to map Israeli gay cinema by situating it in relation to other Israeli and non-Israeli films, the hegemonic values of dominant Israeli culture and the idea/1 of a unified Israeli gay community. Another aim is to explore the ways in which cinema, as a primary source of gay cultural production in Israel, has defined gay identity and community since the late 1970s. The thesis brings together two objects of study. One is Israeli society, including the gay movement. This branch of the research studies the history of the gay movement and the incorporation of gay men and lesbians into the Israeli public sphere. The other is Israeli cinema, including production and distribution apparatuses as well as the film texts themselves. This branch examines representations of gay life on the screen along the axes of ethnicity, gender, nation and religion, the reception of films both in Israel and abroad, and matters of censorship. The thesis focuses on the mutual influences these two objects of study have on one another, namely the way in which cinema has contributed to the promotion of gay causes in Israel, and the way in which gay concerns have enriched Israeli films both visually and thematically. The project crosses and links various disciplines and encompasses different approaches to the films. Combining film theory, institutional and textual analysis, employing the tools of post-colonialism and queer theory as well as theories of race, nation and feminist criticism, I attend to the complexities of the representation of gay culture and identity and its organization and legibility through culture.

Published
2006

46. Inductive and transductive link prediction for criminal network analysis

Author

Ahmadi, Z., Nguyen, H. H., Zhang, Z., Bozhkov, D., Kudenko, D., Jofre, M., Calderoni, Francesco, Cohen, N., Solewicz, Y., Calderoni F. (ORCID:0000-0003-2979-4599), Ahmadi, Z., Nguyen, H. H., Zhang, Z., Bozhkov, D., Kudenko, D., Jofre, M., Calderoni, Francesco, Cohen, N., Solewicz, Y., and Calderoni F. (ORCID:0000-0003-2979-4599)

Abstract

The identification of potential offenders, who are more likely to form a new group and co-offend in a crime, plays an essential role in narrowing down law enforcement investigations and improving predictive policing. Once a crime is committed, focusing on linking it to previously reported crimes and reducing the inspections based on shreds of evidence and the behavior of offenders can also greatly help law enforcement agencies. However, classical investigative techniques are generally case-specific and rely mainly on police officers manually combining information from different sources. Therefore, automatic methods designed to support co-offender research and crime linkage would be beneficial. This paper proposes two graph-based machine learning frameworks to address these issues based on a burglary use case, the first being transductive link prediction, which seeks to predict emergent links between existing graph nodes (which represent offenders or criminal cases), and the other being inductive link prediction, where connections are found between a new case and existing nodes. Our experimental results show a prediction accuracy of 68.5% in co-offender prediction, a 75.83% predictive accuracy for transductive crime linkage, and up to 74.8% accuracy in inductive crime linkage.

Published
2023

47. Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood KMT2A -Rearranged Acute Myeloid Leukemia: A Study by the International Berlin-Frankfurt-Münster Study Group

Author

Van Weelderen, R. E., Klein, K., Harrison, C. J., Jiang, Y., Abrahamsson, J., Arad-Cohen, N., Bart-Delabesse, E., Buldini, B., De Moerloose, B., Dworzak, M. N., Elitzur, S., Fernandez Navarro, J. M., Gerbing, R. B., Goemans, B. F., De Groot-Kruseman, H. A., Guest, E., Ha, S. -Y., Hasle, H., Kelaidi, C., Lapillonne, H., Leverger, G., Locatelli, Franco, Masetti, R., Miyamura, T., Noren-Nystrom, U., Polychronopoulou, S., Rasche, M., Rubnitz, J. E., Stary, J., Tierens, A., Tomizawa, D., Zwaan, C. M., Kaspers, G. J. L., Locatelli F. (ORCID:0000-0002-7976-3654), Van Weelderen, R. E., Klein, K., Harrison, C. J., Jiang, Y., Abrahamsson, J., Arad-Cohen, N., Bart-Delabesse, E., Buldini, B., De Moerloose, B., Dworzak, M. N., Elitzur, S., Fernandez Navarro, J. M., Gerbing, R. B., Goemans, B. F., De Groot-Kruseman, H. A., Guest, E., Ha, S. -Y., Hasle, H., Kelaidi, C., Lapillonne, H., Leverger, G., Locatelli, Franco, Masetti, R., Miyamura, T., Noren-Nystrom, U., Polychronopoulou, S., Rasche, M., Rubnitz, J. E., Stary, J., Tierens, A., Tomizawa, D., Zwaan, C. M., Kaspers, G. J. L., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

PURPOSEA previous study by the International Berlin-Frankfurt-Münster Study Group (I-BFM-SG) on childhood KMT2A-rearranged (KMT2A-r) AML demonstrated the prognostic value of the fusion partner. This I-BFM-SG study investigated the value of flow cytometry-based measurable residual disease (flow-MRD) and evaluated the benefit of allogeneic stem-cell transplantation (allo-SCT) in first complete remission (CR1) in this disease.METHODSA total of 1,130 children with KMT2A-r AML, diagnosed between January 2005 and December 2016, were assigned to high-risk (n = 402; 35.6%) or non-high-risk (n = 728; 64.4%) fusion partner-based groups. Flow-MRD levels at both end of induction 1 (EOI1) and 2 (EOI2) were available for 456 patients and were considered negative (<0.1%) or positive (%0.1%). End points were 5-year event-free survival (EFS), cumulative incidence of relapse (CIR), and overall survival (OS).RESULTSThe high-risk group had inferior EFS (30.3% high risk v 54.0% non-high risk; P <.0001), CIR (59.7% v 35.2%; P <.0001), and OS (49.2% v 70.5%; P <.0001). EOI2 MRD negativity was associated with superior EFS (n = 413; 47.6% MRD negativity v n = 43; 16.3% MRD positivity; P <.0001) and OS (n = 413; 66.0% v n = 43; 27.9%; P <.0001), and showed a trend toward lower CIR (n = 392; 46.1% v n = 26; 65.4%; P =.016). Similar results were obtained for patients with EOI2 MRD negativity within both risk groups, except that within the non-high-risk group, CIR was comparable with that of patients with EOI2 MRD positivity. Allo-SCT in CR1 only reduced CIR (hazard ratio, 0.5 [95% CI, 0.4 to 0.8]; P =.00096) within the high-risk group but did not improve OS. In multivariable analyses, EOI2 MRD positivity and high-risk group were independently associated with inferior EFS, CIR, and OS.CONCLUSIONEOI2 flow-MRD is an independent prognostic factor and should be included as risk stratification factor in childhood KMT2A-r AML. Treatment approaches other than allo-SCT in CR1 are nee

Published
2023

48. A global experiment on motivating social distancing during the COVID-19 pandemic

Author

Legate, N, Ngyuen, T-V, Weinstein, N, Moller, A, Legault, L, Vally, Z, Tajchman, Z, Zsido, AN, Zrimsek, M, Chen, Z, Ziano, I, Gialitaki, Z, Ceary, CD, Jang, Y, Lin, Y, Kunisato, Y, Yamada, Y, Xiao, Q, Jiang, X, Du, X, Yao, E, Ryan, WS, Wilson, JP, Cyrus-Lai, W, Jimenez-Leal, W, Law, W, Unanue, W, Collins, WM, Richard, KL, Vranka, M, Ankushev, V, Schei, V, DePaola, C, Lerche, V, Kovic, V, Križanić, V, Kadreva, VH, Adoric, VC, Tran, US, Yeung, SK, Hassan, W, Houston, R, Machin, MA, Lima, TJS, Ostermann, T, Frizzo, T, Sverdrup, TE, House, T, Gill, T, Fedotov, M, Paltrow, T, Jernsäther, T, Rahman, T, Machin, T, Koptjevskaja-Tamm, M, Hostler, TJ, Ishii, T, Szaszi, B, Adamus, S, Suter, L, von Bormann, SM, Habib, S, Studzinska, A, Stojanovska, D, Janssen, SMJ, Stieger, S, Schulenberg, SE, Tatachari, S, Azouaghe, S, Sorokowski, P, Sorokowska, A, Song, X, Morbée, S, Lewis, S, Sinkolova, S, Grigoryev, D, Drexler, SM, Daches, S, Levine, SL, Geniole, SN, Akter, S, Vračar, S, Massoni, S, Costa, S, Zorjan, S, Sarioguz, E, Izquierdo, SM, Tshonda, SS, Alves, SG, Pöntinen, S, Solas, SÁ, Ordoñez-Riaño, S, Očovaj, SB, Onie, S, Lins, S, Biberauer, T, Çoksan, S, Khumkom, S, Sacakli, A, Ruiz-Fernández, S, Geiger, SJ, FatahModares, S, Walczak, RB, Betlehem, R, Vilar, R, Cárcamo, RA, Ross, RM, McCarthy, R, Ballantyne, T, Westgate, EC, Ryan, RM, Gargurevich, R, Afhami, R, Ren, D, Monteiro, RP, Reips, U-D, Reggev, N, Calin-Jageman, RJ, Pourafshari, R, Oliveira, R, Nedelcheva-Datsova, M, Rahal, R-M, Ribeiro, RR, Radtke, T, Searston, R, Jai-ai, R, Habte, R, Zdybek, P, Chen, S-C, Wajanatinapart, P, Maturan, PLG, Perillo, JT, Isager, PM, Kačmár, P, Macapagal, PM, Maniaci, MR, Szwed, P, Hanel, PHP, Forbes, PAG, Arriaga, P, Paris, B, Parashar, N, Papachristopoulos, K, Correa, PS, Kácha, O, Bernardo, M, Campos, O, Bravo, ON, Galindo-Caballero, OJ, Ogbonnaya, CE, Bialobrzeska, O, Kiselnikova, N, Simonovic, N, Cohen, N, Nock, NL, Hernandez, A, Thogersen-Ntoumani, C, Ntoumanis, N, Johannes, N, 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MS, Manavalan, M, Muminov, A, Kossowska, M, Friedemann, M, Wielgus, M, van Hooff, MLM, Varella, MAC, Standage, M, Nicolotti, M, Colloff, MF, Bradford, M, Vaughn, LA, Eudave, L, Vieira, L, Lu, JG, Pineda, LMS, Matos, L, Pérez, LC, Lazarevic, LB, Jaremka, LM, Smit, ES, Kushnir, E, Ferguson, LJ, Anton-Boicuk, L, Lins de Holanda Coelho, G, Ahlgren, L, Liga, F, Levitan, CA, Micheli, L, Gunton, L-A, Volz, L, Stojanovska, M, Boucher, L, Samojlenko, L, Delgado, LGJ, Kaliska, L, Beatrix, L, Warmelink, L, Rojas-Berscia, LM, Yu, K, Wylie, K, Wachowicz, J, Desai, K, Barzykowski, K, Kozma, L, Evans, K, Kirgizova, K, Emmanuel Agesin, BB, Koehn, MA, Wolfe, K, Korobova, T, Morris, K, Klevjer, K, van Schie, K, Vezirian, K, Damnjanović, K, Thommesen, KK, Schmidt, K, Filip, K, Staniaszek, K, Grzech, K, Hoyer, K, Moon, K, Khaobunmasiri, S, Rana, K, Janjić, K, Suchow, JW, Kielińska, J, Cruz Vásquez, JE, Chanal, J, Beitner, J, Vargas-Nieto, JC, Roxas, JCT, Taber, J, Urriago-Rayo, J, Pavlacic, JM, Benka, J, Bavolar, J, Soto, JA, Olofsson, JK, Vilsmeier, JK, Messerschmidt, J, Czamanski-Cohen, J, Waterschoot, J, Moss, JD, Boudesseul, J, Lee, JM, Kamburidis, J, Joy-Gaba, JA, Zickfeld, J, Miranda, JF, Verharen, JPH, Hristova, E, Beshears, JE, Djordjevic, JM, Bosch, J, Valentova, JV, Antfolk, J, Berkessel, JB, Schrötter, J, Urban, J, Röer, JP, Norton, JO, Silva, JR, Pickering, JS, Vintr, J, Uttley, J, Kunst, JR, Ndukaihe, ILG, Iyer, A, Vilares, I, Ivanov, A, Ropovik, I, Sula, I, Sarieva, I, Metin-Orta, I, Prusova, I, Pinto, I, Bozdoc, AI, Almeida, IAT, Pit, IL, Dalgar, I, Zakharov, I, Arinze, AI, Ihaya, K, Stephen, ID, Gjoneska, B, Brohmer, H, Flowe, H, Godbersen, H, Kocalar, HE, Hedgebeth, MV, Chuan-Peng, H, Sharifian, M, Manley, H, Akkas, H, Hajdu, N, Azab, H, Kaminski, G, Nilsonne, G, Anjum, G, Travaglino, GA, Feldman, G, Pfuhl, G, Czarnek, G, Marcu, GM, Hofer, G, Banik, G, Adetula, GA, Bijlstra, G, Verbruggen, F, Kung, FYH, Martela, F, Foroni, F, Forest, J, Singer, G, Muchembled, F, 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Zickfeld, J, Miranda, J, Verharen, J, Hristova, E, Beshears, J, Djordjevic, J, Bosch, J, Valentova, J, Antfolk, J, Berkessel, J, Schrotter, J, Urban, J, Roer, J, Norton, J, Silva, J, Pickering, J, Vintr, J, Uttley, J, Kunst, J, Ndukaihe, I, Iyer, A, Vilares, I, Ivanov, A, Ropovik, I, Sula, I, Sarieva, I, Metin-Orta, I, Prusova, I, Pinto, I, Bozdoc, A, Almeida, I, Pit, I, Dalgar, I, Zakharov, I, Arinze, A, Ihaya, K, Stephen, I, Gjoneska, B, Brohmer, H, Flowe, H, Godbersen, H, Kocalar, H, Hedgebeth, M, Chuan-Peng, H, Sharifian, M, Manley, H, Akkas, H, Hajdu, N, Azab, H, Kaminski, G, Nilsonne, G, Anjum, G, Travaglino, G, Feldman, G, Pfuhl, G, Czarnek, G, Marcu, G, Hofer, G, Banik, G, Adetula, G, Bijlstra, G, Verbruggen, F, Kung, F, Martela, F, Foroni, F, Forest, J, Singer, G, Muchembled, F, Azevedo, F, Mosannenzadeh, F, Marinova, E, Strukelj, E, Etebari, Z, Bradshaw, E, Baskin, E, Garcia, E, Musser, E, van Steenkiste, I, Ahn, E, Quested, E, Pronizius, E, Jackson, E, Manunta, E, 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N., Zrimsek, M., Chen, Z., Ziano, I., Gialitaki, Z., Basnight-Brown, D. M., Ceary, C. D., Jang, Y., Ijzerman, H., Lin, Y., Kunisato, Y., Yamada, Y., Xiao, Q., Jiang, X., Du, X., Yao, E., Ryan, W. S., Wilson, J. P., Cyrus-Lai, W., Jimenez-Leal, W., Law, W., Unanue, W., Collins, W. M., Richard, K. L., Vranka, M., Ankushev, V., Schei, V., Lerche, V., Kovic, V., Krizanic, V., Kadreva, V. H., Adoric, V. C., Tran, U. S., Yeung, S. K., Hassan, W., Houston, R., Urry, H. L., Machin, M. A., Lima, T. J. S., Ostermann, T., Frizzo, T., Sverdrup, T. E., House, T., Gill, T., Fedotov, M., Paltrow, T., Moshontz, H., Jernsather, T., Rahman, T., Machin, T., Koptjevskaja-Tamm, M., Hostler, T. J., Ishii, T., Szaszi, B., Adamus, S., Suter, L., Von Bormann, S. M., Habib, S., Studzinska, A., Stojanovska, D., Janssen, S. M. J., Stieger, S., Primbs, M. A., Schulenberg, S. E., Buchanan, E. M., Tatachari, S., Azouaghe, S., Sorokowski, P., Sorokowska, A., Song, X., Morbee, S., Lewis, S., Sinkolova, S., Grigoryev, D., Drexler, S. M., Daches, S., Levine, S. L., Geniole, S. N., Akter, S., Vracar, S., Massoni, S., Costa, S., Zorjan, S., Sarioguz, E., Izquierdo, S. M., Tshonda, S. S., Miller, J. K., Alves, S. G., Pontinen, S., Solas, S. A., Ordonez-Riano, S., Ocovaj, S. B., Onie, S., Lins, S., Biberauer, T., Coksan, S., Khumkom, S., Sacakli, A., Coles, N. A., Ruiz-Fernandez, S., Geiger, S. J., Fatahmodares, S., Walczak, R. B., Betlehem, R., Vilar, R., Carcamo, R. A., Ross, R. M., Mccarthy, R., Ballantyne, T., Westgate, E. C., Ryan, R. M., Gargurevich, R., Afhami, R., Ren, D., Monteiro, R. P., Reips, U. -D., Reggev, N., Calin-Jageman, R. J., Pourafshari, R., Oliveira, R., Nedelcheva-Datsova, M., Rahal, R. -M., Ribeiro, R. R., Radtke, T., Searston, R., Jai-Ai, R., Habte, R., Zdybek, P., Chen, S. -C., Wajanatinapart, P., Maturan, P. L. G., Perillo, J. T., Isager, P. M., Kacmar, P., Macapagal, P. M., Maniaci, M. R., Szwed, P., Hanel, P. H. P., Forbes, P. A. G., Arriaga, P., Paris, B., Parashar, N., Papachristopoulos, K., Chartier, C. R., Correa, P. S., Kacha, O., Bernardo, M., Campos, O., Bravo, O. N., Mallik, P. R., Galindo-Caballero, O. J., Ogbonnaya, C. E., Bialobrzeska, O., Kiselnikova, N., Simonovic, N., Cohen, N., Nock, N. L., Hernandez, A., Thogersen-Ntoumani, C., Ntoumanis, N., Johannes, N., Albayrak-Aydemir, N., Say, N., Neubauer, A. B., Martin, N. I., Torunsky, N., Van Antwerpen, N., Van Doren, N., Sunami, N., Rachev, N. R., Majeed, N. M., Schmidt, N. -D., Nadif, K., Forscher, P. S., Corral-Frias, N. S., Ouherrou, N., Abbas, N., Pantazi, M., Lucas, M. Y., Vasilev, M. R., Ortiz, M. V., Butt, M. M., Kurfali, M., Kabir, M., Muda, R., Del Carmen, M. C. Tejada Rivera M., Sirota, M., Seehuus, M., Parzuchowski, M., Toro, M., Hricova, M., Maldonado, M. A., Arvanitis, A., Rentzelas, P., Vansteenkiste, M., Metz, M. 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Subjects
behavior change, Coronavirus disease 2019 (COVID-19), 230 Affective Neuroscience, INTENTIONS, L400, self-determination theory, Physical Distancing, Social Sciences, Intention, Ciências Sociais::Psicologia [Domínio/Área Científica], FATIGUE, motivation, PARENTAL PROHIBITION, SDG 3 - Good Health and Well-being, Pandemic, Humans, health communication, MESSAGES, Sociology, Pandemics, METAANALYSIS, COVID-19, Behaviour Change and Well-being, Multidisciplinary, business.industry, Social distance, Public relations, Motivation, INTERNALIZATION, business, BEHAVIOR
Abstract

Significance\ud \ud Communicating in ways that motivate engagement in social distancing remains a critical global public health priority during the COVID-19 pandemic. This study tested motivational qualities of messages about social distancing (those that promoted choice and agency vs. those that were forceful and shaming) in 25,718 people in 89 countries. The autonomy-supportive message decreased feelings of defying social distancing recommendations relative to the controlling message, and the controlling message increased controlled motivation, a less effective form of motivation, relative to no message. Message type did not impact intentions to socially distance, but people’s existing motivations were related to intentions. Findings were generalizable across a geographically diverse sample and may inform public health communication strategies in this and future global health emergencies.\ud \ud \ud \ud Abstract\ud \ud Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one’s core values) or behavioral intentions. Results supported hypothesized associations between people’s existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges.

Published
2022

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