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Naturalists enrich our scientific understanding of biodiversity. However, just as countries have fallen behind on commitments to provide biodiversity conservation funding, so has the focus of life science stayed arm's length. The purpose of this article is to consider why biodiversity should be the center of life sciences education and how biographies of Charles Darwin and the incorporation of female scientists allow important findings, paintings, and journaling as part of standard teachings. The addition of female naturalists will provide role models for diverse, underrepresented student populations. This article suggests that biodiversity and biography become central to teaching life sciences while supplemented by other practices. Such reallocations provide students an opportunity to learn not only what these scientists discovered but how these individuals "developed" into scientists.

Microscopy is not specifically mentioned in the Next Generation Science Standards (NGSS), and consequently secondary education limits its use to learning parts, procedures, and observing fixed specimen slides. However, when alternative approaches (See Section IV in this paper) are encouraged, microscopy provides opportunities for hands-on learning, engagement, use of models, and gaining a sense of size, scale, and hierarchical organisation. This article reviews living organism- and ecosystem-based microscopy originally designed for gifted and talented education, and how it could support the NGSS Life Science Framework. The paper begins with a review of curriculum, then discusses (1) five ongoing microscope applications relevant to the NGSS, including mini-ponds modelling ecosystem-organism functions; (2) data from pre- and post-testing as a measure of comprehensive learning; and (3) a culminating communication project/exhibit on pond life, environmental conditions, and pollution effects.

Background: The growing popularity of aesthetic procedures involving fillers, biostimulators, and neurotoxins has prompted concerns about patient safety. To address these concerns, a global Safety Task Force (STF) was formed. Aims: The inaugural STF meeting prioritized vascular compromise prevention and management, guiding clinical trial design and materials for future meetings, and collecting data from experts on current safety methods. Methods: The STF was formed and consisted of 16 experts from nine different countries, with each possessing distinct expertise in various fields related to aesthetic injectables. Current safety data, protocols, knowledge gaps and future research priorities were discussed and voted upon. Results: The establishment of a global database for tracking filler‐related AEs was favored by 93% of participants. Discussions revolved around the database's scope, data standardization, and whether non‐medical contributors should be included. Aspiration as a safety technique garnered support from 73% of participants. Approximately 43% of participants incorporate ultrasound in their injections, with divergent opinions on its impact and potential when used as a standard of practice versus in AE management. Most physicians on the task force incorporated cannula use for some of their injections (93%). There were varying perspectives on treatments for vascular adverse events (VAE), the primary causes, and the adoption of new protocols in the field. Conclusions: The STF meeting underscored the need for a coordinated effort to address complications related to HA fillers, including VAE management and hyaluronidase protocols. Reliable treatment endpoints were evaluated, but improved measurement methods are needed. Future meetings will focus on addressing delayed complications, furthering safety in this field. [ABSTRACT FROM AUTHOR]

Background: Artificial intelligence (AI) and large language models (LLMs) transform how patients inform themselves. LLMs offer potential as educational tools, but their quality depends upon the information generated. Current literature examining AI as an informational tool in dermatology has been limited in evaluating AI's multifaceted roles and diversity of opinions. Here, we evaluate LLMs as a patient‐educational tool for Mohs micrographic surgery (MMS) in and out of the clinic utilizing an international expert panel. Methods: The most common patient MMS questions were extracted from Google and transposed into two LLMs and Google's search engine. 15 MMS surgeons evaluated the generated responses, examining their appropriateness as a patient‐facing informational platform, sufficiency of response in a clinical environment, and accuracy of content generated. Validated scales were employed to assess the comprehensibility of each response. Results: The majority of reviewers deemed all LLM responses appropriate. 75% of responses were rated as mostly accurate or higher. ChatGPT had the highest mean accuracy. The majority of the panel deemed 33% of responses sufficient for clinical practice. The mean comprehensibility scores for all platforms indicated a required 10th‐grade reading level. Conclusions: LLM‐generated responses were rated as appropriate patient informational sources and mostly accurate in their content. However, these platforms may not provide sufficient information to function in a clinical environment, and complex comprehensibility may represent a barrier to utilization. As the popularity of these platforms increases, it is important for dermatologists to be aware of these limitations. [ABSTRACT FROM AUTHOR]

Mechanical force controls the opening and closing of mechanosensitive ion channels atop the hair bundles of the inner ear. The filamentous tip link connecting transduction channels to the tallest neighboring stereocilium modulates the force transmitted to the channels and thus changes their probability of opening. Each tip link comprises four molecules: a dimer of protocadherin 15 (PCDH15) and a dimer of cadherin 23, all of which are stabilized by Ca2+ binding. Using a high-speed optical trap to examine dimeric PCDH15, we find that the protein's mechanical properties are sensitive to Ca2+ and that the molecule exhibits limited unfolding at a physiological Ca2+ concentration. PCDH15 can therefore modulate its stiffness without undergoing large unfolding events under physiological conditions. The experimentally determined stiffness of PCDH15 accords with published values for the stiffness of the gating spring, the mechanical element that controls the opening of mechanotransduction channels. When PCDH15 exhibits a point mutation, V507D, associated with nonsyndromic hearing loss, unfolding events occur more frequently under tension and refolding events occur less often than for the wild-type protein. Our results suggest that the maintenance of appropriate tension in the gating spring is critical to the appropriate transmission of force to transduction channels, and hence to hearing. [ABSTRACT FROM AUTHOR]

BACKGROUND AbobotulinumtoxinA has become well established as a treatment option for moderate to severe glabellar lines since its first aesthetic approval in 2009. OBJECTIVE Pivotal trials leading to regulatory approval showed that abobotulinumtoxinA treatment was associated with high responder rates when defined as achievement of none or mild glabellar lines (0 or 1 on the glabellar line severity scale) and a duration of action of up to 5 months. More recently, the goals for treatment of glabellar lines have shifted toward not only achieving a decrease in glabellar line severity but also ensuring that patients are satisfied with their experience. MATERIALS AND METHODS Patients seek an improvement in the appearance of their glabellar lines while maintaining a "natural look," fast onset of effect, and long duration of response. RESULTS Trial designs have evolved to meet these new targets, including expanding the definition of responders to those having at least 1-grade improvement in the glabellar line severity scale score from baseline coupled with the use of subject satisfaction and psychological well-being questionnaires. CONCLUSION The findings demonstrate that abobotulinumtoxinA remains a well-tolerated and consistently effective treatment option associated with a rapid onset of effect, duration of efficacy lasting up to 6 months, and high, long-lasting levels of patient satisfaction. [ABSTRACT FROM AUTHOR]

Introduction: Real‐world experience using an allograft adipose matrix (AAM) (Renuva) is presented as a series of seven cases demonstrating successful use of the matrix by nine expert cosmetic physicians across the United States. AAM is donated tissue that is aseptically processed without terminal irradiation into a transplantable adipose matrix that functions as a natural, versatile, and nonimmunogenic cushioning and volume‐restoring tissue. When injected, the adipose matrix is replaced with the body's own fat cells and provides the cellular scaffold required for volume restoration and retention. Methods: Nine expert dermatologists were selected to share and discuss real‐world patient cases using AAM. The experts discussed a variety of cases and selected 7 cases that demonstrated successful, novel use of AAM to present in this manuscript. Results: Experts agreed that the novel AAM is an easy‐to‐use, effective, and safe alternative to traditional fillers and fat grafting. Conclusion: The use of the AAM is recommended for the face, hands, and other adipose tissue‐containing parts of the body. The presented real‐world cases provide guidance on how to identify ideal candidates to ensure optimal volume restoration results. [ABSTRACT FROM AUTHOR]

Background: Medical aesthetic procedures for facial rejuvenation with laser and energy‐based devices (EBDs) are rapidly increasing. The following cases highlight real‐life experience using a multi‐modality system with various handpieces that combine intense pulsed light (IPL), laser hair removal (808 diode), high‐intensity focused ultrasound (HIFU), radiofrequency microneedling (RFM), and thermal radiofrequency (RF) for antiaging and rejuvenation treatment. Laser and RFM treatments may improve skin conditions by inducing cutaneous changes that remodel the skin matrix. Methods: Six physicians who treat patients for skin rejuvenation reported on clinical cases from their practice using a multi‐modality system with various handpieces. Results: During the meeting, the advisors discussed 15 cases and agreed to select seven patients with different ages and skin phototypes receiving various treatments for photodamage of the face, neck, and décolleté. The advisors discussed why they selected the case, previous treatment, type of treatment, results, and clinical pearls. Conclusion: Sharing best practices in medical aesthetics using combination treatments on a single multi‐modality energy‐based device such as laser and MRF for facial, neck, and chest skin may support healthcare providers treating patients for skin rejuvenation to improve clinical outcomes. [ABSTRACT FROM AUTHOR]

ImportanceThe notion that systemic isotretinoin taken within 6 to 12 months of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and practiced; however, it is based on 3 small case series from the mid-1980s.ObjectiveTo evaluate the body of literature to provide evidence-based recommendations regarding the safety of procedural interventions performed either concurrently with, or immediately following the cessation of systemic isotretinoin therapy.Evidence reviewA panel of national experts in pediatric dermatology, procedural/cosmetic dermatology, plastic surgery, scars, wound healing, acne, and isotretinoin was convened. A systematic PubMed review of English-language articles published from 1982 to 2017 was performed using the following search terms: isotretinoin, 13-cis-retinoic acid, Accutane, retinoids, acitretin, surgery, surgical, laser, ablative laser, nonablative laser, laser hair removal, chemical peel, dermabrasion, wound healing, safety, scarring, hypertrophic scar, and keloid. Evidence was graded, and expert consensus was obtained.FindingsThirty-two relevant publications reported 1485 procedures. There was insufficient evidence to support delaying manual dermabrasion, superficial chemical peels, cutaneous surgery, laser hair removal, and fractional ablative and nonablative laser procedures for patients currently receiving or having recently completed isotretinoin therapy. Based on the available literature, mechanical dermabrasion and fully ablative laser are not recommended in the setting of systemic isotretinoin treatment.Conclusions and relevancePhysicians and patients may have an evidence-based discussion regarding the known risk of cutaneous surgical procedures in the setting of systemic isotretinoin therapy. For some patients and some conditions, an informed decision may lead to earlier and potentially more effective interventions.

Taylor's law (TL) describes the relationship between the variance and mean of population density: log10(variance) ≈ log10(a) + b × log10(mean), a > 0. This study analyzed the temporal TL, for which mean and variance are calculated over time, separately for each population in a collection of populations, considering the effects of the parameters of the Gompertz model (a second‐order autoregressive time‐series model) and the skewness of the density frequency distribution. Time series of 162 populations of the gray‐sided vole in Hokkaido, Japan, spanning 23–31 years, satisfied the temporal TL: log10(variancej) ≈ 0.199 + 1.687 × log10(meanj). This model explained 62% of the variation of log10(variancej). An extended model with explanatory variables log10(meanj), the density‐dependent coefficient for 1‐year lag (α1,j), that for 2‐year lag (α2,j), the density‐independent variability (σj2), and the skewness (γj), explained 93.9% of the log10(variancej) variation. In the extended model, the coefficient of log10(meanj) was 1.949, close to the null value (b = 2) of the TL slope. The standardized partial regression coefficients indicated that density‐independent effects (σj2 and γj) dominated density‐dependent effects (α1,j and α2,j) apart from log10(meanj). The negative correlations observed between σj2 and log10(meanj), and between γj and log10(meanj), played an essential role in explaining the difference between the estimated slope of TL (b = 1.687) and the null slope (b = 2). The effects of those explanatory variables on log10(variancej) were interpreted based on the theory of a second‐order autoregressive time‐series model. [ABSTRACT FROM AUTHOR]

Background: Keratoacanthomas (KAs) following laser treatment are a rare, but well‐described entity. Aim: Herein, we describe a case of eruptive keratoacanthoma (KA) following laser resurfacing treatment and aim to better characterize laser‐associated KAs. Methods: A literature search was performed on PubMed reviewing laser‐associated KAs including various characteristics: epidemiology, history of skin cancer, location, and number, type of laser, as well as the management and outcome. Results: Fractional ablative was the most common type of laser triggering KAs, and most cases presented within the first month following treatment. The majority of cases of laser‐induced KA had a prior history of a malignant or premalignant skin neoplasm. Laser‐induced KAs were treated using modalities similar to KAs arising in other contexts. Conclusion: Clinicians need to be knowledgeable and prepared to understand, and manage complications following laser treatments, as rare as they may be, including KAs. [ABSTRACT FROM AUTHOR]