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1. Prediction of postnatal circulation in pulmonary atresia/critical stenosis with intact ventricular septum: systematic review and external validation of models

Author

Villalaín, Cecilia, Moon‐Grady, A. J., Herberg, U., Strainic, J., Cohen, J. L., Shah, A., Levi, D. S., Gómez Montes, María Enery, Herraiz García, Ignacio, Galindo Izquierdo, Alberto, Villalaín, Cecilia, Moon‐Grady, A. J., Herberg, U., Strainic, J., Cohen, J. L., Shah, A., Levi, D. S., Gómez Montes, María Enery, Herraiz García, Ignacio, and Galindo Izquierdo, Alberto

Abstract

ObjectiveA favorable postnatal prognosis in cases ofpulmonary atresia/critical stenosis with intact ventricu-lar septum (PA/CS-IVS) is generally equated with thepossibility of achieving biventricular (BV) repair. Identi-fication of fetuses that will have postnatal univentricular(UV) circulation is key for prenatal counseling, opti-mization of perinatal care and decision-making regardingfetal therapy. We aimed to evaluate the accuracy ofCorrespondence to:Dr C. Villala ́ın, Department of Obstetrics and Gynecology, Hospital Universitario 12 de Octubre, Avenida de C ́ordoba,Madrid 28041, Spain (e-mail: ceci.gvillalain@gmail.com)Accepted: 23 January 2023published models for predicting postnatal circulation inPA/CS-IVS using a large internationally derived validationcohort.MethodsThis was a systematic review of publisheduni- and multiparametric models for the predictionof postnatal circulation based on echocardiographicfindings at between 20 and 28 weeks of gestation.Models were externally validated using data fromthe International Fetal Cardiac Intervention Registry.Sensitivity, specificity, predictive values, area underthe receiver-operating-characteristics curves (AUCs) andproportion of cases with truevspredicted outcome werecalculated.ResultsEleven published studies that reported prog-nostic parameters of postnatal circulation were iden-tified. Models varied widely in terms of the mainoutcome (UV (n=3), non-BV (n=3), BV (n=3),right-ventricle-dependent coronary circulation (n=1) ortricuspid valve size at birth (n=1)) and in terms ofthe included predictors (single parameters only (n=6),multiparametric score (n=4) or both (n=1)), and weredeveloped on small sample sizes (range, 15 – 38). Ninemodels were validated externally given the availability ofthe required parameters in the validation cohort. Tricus-pid valve diameterZ-score, tricuspid regurgitation, ratiosbetween right and left cardiac structures and the presence. Postnatal circulation in pulmonary atresia15of ventr, Objetivo.Un pron ́ostico postnatal favorable en casos de atresia pulmonar/estenosis cr ́ıtica con tabique interventricularintacto (PA/CS-IVS, por sus siglas en ingl ́es) se equipara generalmente con la posibilidad de lograr una reparaci ́onbiventricular (BV). La identificaci ́on de los fetos que tendr ́an circulaci ́on univentricular (UV) postnatal es clave parael asesoramiento prenatal, la optimizaci ́on de los cuidados perinatales y la toma de decisiones relativas a la terapiafetal. El objetivo fue evaluar la precisi ́on de los modelos publicados para predecir la circulaci ́on postnatal en casos dePA/CS-IVS utilizando para ello una gran cohorte de validaci ́on estimada a partir de datos internacionales.M ́etodos.El estudio consisti ́oenunarevisi ́on sistem ́atica de los modelos uni- y multiparam ́etricos publicados para lapredicci ́on de la circulaci ́on postnatal basados en los hallazgos ecocardiogr ́aficos entre las semanas 20 y 28 de gestaci ́on.Los modelos se validaron externamente utilizando datos del Registro Internacional de Intervenciones Card ́ıacas Fetales.Se calcularon la sensibilidad, la especificidad, los valores predictivos, el ́area bajo las curvas (ABC) de caracter ́ısticasoperativas del receptor y la proporci ́on de casos con resultado verdadero frente a resultado pronosticado.Resultados.Se identificaron once estudios publicados en los que se hab ́ıan reportado par ́ametros pron ́osticos de lacirculaci ́on postnatal. Los modelos variaron ampliamente en cuanto al resultado principal (UV (n=3), no-BV (n=3), BV(n=3), la circulaci ́on coronaria dependiente del ventr ́ıculo derecho (n=1)oeltama ̃no de la v ́alvula tric ́uspide al nacer(n=1)) y en cuanto a los predictores incluidos (s ́olo par ́ametros ́unicos (n=6), puntuaci ́on multiparam ́etrica (n=4) oambos (n=1)), y se desarrollaron a partir de muestras peque ̃nas (rango, 15 – 38).Dada la disponibilidad de los par ́ametros requeridos en la cohorte de validaci ́on, se validaron externamente nuevemod, Depto. de Medicina, Fac. de Medicina, TRUE, pub, APC financiada por la UCM

Published
2024

2. Filtered Talbot lens: Producing $\lambda /2n$-periodic atomic patterns with standing wave fields having period $\lambda $

Author

Cohen, J. L., Dubetsky, B., Berman, P. R., and Schmiedmayer, J.

Subjects
Physics - Atomic Physics
Abstract

We propose a scheme to create high-contrast, periodic atom density distributions having period $\lambda /2n$ using the Talbot effect, where $% \lambda $ is the wave length of the optical fields that scatter the atoms and $n$ is a positive integer. This {\em filtered Talbot lens} is comprised of two standing-wave optical fields. An atomic beam propagates perpendicular to the fields. The first field, which is far-detuned from the atomic transition frequency, acts as an array of lenses that focuses the atoms. The second field, positioned at the atom optical focus of the first, is resonant with the atomic transition frequency and acts as an amplitude mask, leaving unperturbed only those atoms that pass through its nodes. At distances following the interaction with the second field that are equal to an integral fraction of the Talbot length, atomic density gratings having period $\lambda /2n$ are formed., Comment: 7 pages, 3 figures

Published
1999
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3. Atom focusing by far-detuned and resonant standing wave fields: Thin lens regime

Author

Cohen, J. L., Dubetsky, B., and Berman, P. R.

Subjects
Physics - Atomic Physics
Abstract

The focusing of atoms interacting with both far-detuned and resonant standing wave fields in the thin lens regime is considered. The thin lens approximation is discussed quantitatively from a quantum perspective. Exact quantum expressions for the Fourier components of the density (that include all spherical aberration) are used to study the focusing numerically. The following lens parameters and density profiles are calculated as functions of the pulsed field area $\theta $: the position of the focal plane, peak atomic density, atomic density pattern at the focus, focal spot size, depth of focus, and background density. The lens parameters are compared to asymptotic, analytical results derived from a scalar diffraction theory for which spherical aberration is small but non-negligible ($\theta \gg 1$). Within the diffraction theory analytical expressions show that the focused atoms in the far detuned case have an approximately constant background density $0.5(1-0.635\theta ^{- 1/2})$ while the peak density behaves as $% 3.83\theta ^{1/2}$, the focal distance or time as $\theta ^{-1}(1+1.27\theta ^{- 1/2})$, the focal spot size as $0.744\theta ^{-3/4}$, and the depth of focus as $1.91\theta ^{- 3/2}$. Focusing by the resonant standing wave field leads to a new effect, a Rabi- like oscillation of the atom density. For the far-detuned lens, chromatic aberration is studied with the exact Fourier results. Similarly, the degradation of the focus that results from angular divergence in beams or thermal velocity distributions in traps is studied quantitatively with the exact Fourier method and understood analytically using the asymptotic results. Overall, we show that strong thin lens focusing is possible with modest laser powers and with currently achievable atomic beam characteristics., Comment: 21 pages, 11 figures

Published
1999
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4. Talbot Oscillations and Periodic Focusing in a One-Dimensional Condensate

Author

Rojo, A. G., Cohen, J. L., and Berman, P. R.

Subjects
Physics - Atomic Physics
Abstract

An exact theory for the density of a one-dimensional Bose-Einstein condensate with hard core particle interactions is developed in second quantization and applied to the scattering of the condensate by a spatially periodic impulse potential. The boson problem is mapped onto a system of free fermions obeying the Pauli exclusion principle to facilitate the calculation. The density exhibits a spatial focusing of the probability density as well as a periodic self-imaging in time, or Talbot effect. Furthermore, the transition from single particle to many body effects can be measured by observing the decay of the modulated condensate density pattern in time. The connection of these results to classical and atom optical phase gratings is made explicit.

Published
1999
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5. Quasiperiodic Atom Optics, Focusing, and Wave packet Rephasing

Author

Cohen, J. L., Dubetsky, B., and Berman, P. R.

Subjects
Physics - Atomic Physics
Abstract

We propose a laser field configuration which acts as a quasiperiodic atom optical diffraction grating. Analytical and computational results for the atomic center-of-mass wavefunction after the grating reveal a quasiperiodic density pattern, a semiclassical focusing effect, and a quasiperiodic self-imaging of the atomic wavefunction analogous to a Talbot effect., Comment: 5 pages and 4 figures

Published
1998

6. High resolution amplitude and phase gratings in atom optics

Author

Berman, P. R., Dubetsky, B., and Cohen, J. L.

Subjects
Physics - Atomic Physics, Physics - Optics
Abstract

An atom-field geometry is chosen in which an atomic beam traverses a field interaction zone consisting of three fields, one having frequency $\Omega =c/\lambda $ propagating in the $\hat{z}$ direction and the other two having frequencies $\Omega +\delta_{1}$ and $\Omega +\delta_{2}$ propagating in the -$\hat{z}$ direction. For $n_{1}\delta_{1}+n_{2}\delta_{2}=0$ and $|\delta_{1}| T,|\delta_{2}| T\gg 1$, where $n_{1}$ and $n_{2}$ are positive integers and $T$ is the pulse duration in the atomic rest frame, the atom-field interaction results in the creation of atom amplitude and phase gratings having period $% \lambda /[2(n_{1}+n_{2})]$. In this manner, one can use optical fields having wavelength $\lambda $ to produce atom gratings having periodicity much less than $\lambda $., Comment: 11 pages, 14 figures

Published
1998
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7. Efficacy and safety of tirbanibulin 1% ointment in actinic keratoses: Data from two phase‐III trials and the real‐life clinical practice presented at the European Academy of Dermatology and Venereology Congress 2022.

Author

Pellacani, G., Schlesinger, T., Bhatia, N., Berman, B., Lebwohl, M., Cohen, J. L., Patel, G. K., Kunstfeld, R., Hadshiew, I., and Lear, J. T.

Subjects
ACTINIC keratosis, CLINICAL trials, KERATOSIS, DERMATOLOGY, TRANSPLANTATION of organs, tissues, etc., DERMATOLOGISTS
Abstract

Background: The 31st European Academy of Dermatology and Venereology (EADV) Congress took place between 7th and 10th of September 2022 in Milan, Italy. Objectives: We report presented clinical data on the efficacy/effectiveness, safety and tolerability of tirbanibulin 1% ointment that has recently been licensed for actinic keratosis (AK) of the face or scalp in adults. Methods: Summary of presentations given at the EADV Congress. Results: Prof. Pellacani presented two post hoc analyses from two phase‐III trials with AK patients (NCT03285477 [N = 351] and NCT03285490 [N = 351]): A descriptive analysis of medical history, concomitant medications, and safety results confirming a favourable profile for tirbanibulin showing that number of baseline AK lesions was not correlated to severity of local skin reactions. The latter analysis showed that cases of tirbanibulin application site pain or pruritus were few, and most were found to be mild. Prof. Kunstfeld reported six real‐life clinical cases in Austria showing good tirbanibulin effectiveness, safety and tolerability for the treatment of new or recurring AK lesions. Results demonstrated that after 2‐ to 4‐month follow‐up, tirbanibulin was well tolerated and effective in AK patients. Presentations by Dr. Patel confirmed good outcomes and tolerability of tirbanibulin in Olsen grade 1–2 AK (N = 12) and porokeratosis patients (N = 4) treated once daily for 5 consecutive days in the United Kingdom. Furthermore, real‐world experience in solid organ transplant recipients (N = 2) demonstrated effectiveness of tirbanibulin in skin field cancerization treatment. A symposium sponsored by Almirall was conducted during the congress in which Dr. Hadshiew and Dr. Lear brought together their clinical experience in Germany and the United Kingdom respectively. Interesting clinical cases of 5 consecutive days of tirbanibulin treatment compared to other treatments were discussed with attendees, as well as current treatment needs of AK patients. Conclusions: This article provides an overview of presentations and symposium discussions, summarizing key phase‐III results and real‐life clinical experience with tirbanibulin shared by dermatologists across Europe. [ABSTRACT FROM AUTHOR]

Published
2024
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22. American Society of Colon and Rectal Surgeons 95th Annual Convention Podium and Poster Abstracts June 9–14, 1996 Seattle, Washington

Author

Obrand, D., Gordon, P. H., Rowley, S., Grace, R. H., Rai, S., Moran, M. R., Rai, A. M., Farouk, R., Lee, P. W. R., Edwards, J., Thorne, M., MacDonald, A. W., Duthie, G. S., Monson, J. R. T., Shabahang, M., Brenner, R., Wright, A., Montgomery, E., Trock, B., Buras, R., Schumaker, L., Nolla, J., Buffan, A., Uskokovic, M., Nauta, R., Evans, S., Velázquez, O. C., Zhou, D., Seto, R. W., Choi, J., Jabbar, A., Breen, F., Rombeau, J. L., Casillas, S., Dietz, D. W., Brand, M. I., Vladisavljevic, A., Jones, S. C., Milsom, J. W., Stuntz, M., Wilmoth, G., Ong, J., Stabile, B., Stamos, M. J., Kahn, H., Alexander, A., Rakinic, J., Nagle, D., Fry, R., Simons, A. J., Kerr, R., Toms, C., Groshen, S., Ross, R., Morris, M., Beart, R., Ortega, A., Anthone, G., Lucha, P., Rosen, L., Stasik, J., Olenwine, J., Riether, R., Khubchandani, I., Ogunbivi, O., Birnbaum, E., Fleshman, J., Kodner, I., McLeod, R. S., Geerts, W., Sniderman, K., Greenwood, C., Gregoire, R., Taylor, B., Silverman, R., Atkinson, K., Burnstein, M., Marshall, J., Burul, C., Anderson, D., Ross, T., Wilson, S., Barton, P., Maetani, S., Onodera, H., Morimoto, H., Imamura, M., Hyams, D. M., Mamounas, E., Petrelli, N., Rockette, H., Jones, J., Wolmark, N., Sofo, L., Ratto, C., Valentini, V., Ippoliti, M., Nucera, P., Merico, M., Bellantone, R., Doglietto, G. B., Crucitti, F., Goes, R., Simons, A., Gunderson, L., Grado, G., Streeter, O., Sun, J. H., Decanini-Garza, P., Kim, D. G., Wong, W. D., Rothenberger, D. A., Madoff, R. D., Madlensky, L., Berk, T., Bapat, B., Redston, M., Gallinger, S., Cohen, Z., Winde, G., Schmid, K. W., Brandt, B., Müller, R., Osswald, H., Jang, Y., Steinhagen, R., Heimann, T., Schnitzler, M., Blackstein, M., McLeod, R., Devesa, J. M., Madrid, J. M. Fernandez, Enriquez, J. M., Geerdes, B. P., Heineman, E., Konsten, J., Baeten, C. G. M., Michot, F., Lehur, P. A., Denis, P., Grise, P. H., Leborgne, J., Teniere, P., Buzelin, J. M., Stebbing, J. F., Brading, A. F., Mortensen, N. J. McC, Gunn, J., Gardiner, A., Abdullah, N., Nyam, D. C. N. K., Pemberton, J. H., Ilstrup, D., Lund, J. N., Scholefield, J. H., Stamm, L., Matzel, K. E., Stadelmaier, U., Dünne, A., Hohenberger, W., Sala, C., Garcia-Granero, E., Molina, M. J., Garcia, J. V., Lledo, S., Ternent, C. A., Shashidharan, M., Blatchford, G. J., Christensen, M. A., Thorson, A. G., Sentovich, S. M., Jensen, L. L., Lowry, A. C., Zaheer, S., Reilly, W. T., Tsang, C., Singer, D., Richard, C. S., Stern, H. S., Oliveira, L., Daniel, N., Bernstein, M., DeMarta, D., Weiss, E. G., Nogueras, J. J., Wexner, S. D., Keighley, M. R. B., Korsgen, S., Agachan, F., Kim, D. -S., Goldberg, S. M., Durham, R. M., Pruitt, G., Longo, W. E., Marchesa, P., Oliart, S., Goldblum, J., Fazio, V. W., Rantis, P. C., Daniel, G. L., Vernava, III, A. M., Becker, J. M., Marie, G. St., Ferzoco, S., Franklin, M., Rosenthal, D., Goldstein, E. T., Bass, E. M., DelPino, A., Tan, A., Pearl, R., Orsay, C., Sher, M. E., Sands, L. R., Påhlman, Lars, Hewett, P. J., Thomas, W. M., King, G., Eaton, M., Allendorf, U. D. F., Bessler, M., Whelan, R. L., Trokel, M., Laird, D., Nowygrod, R., Treat, M. R., Vukasin, P., Steele, G., Weston, L., Allendorf, J. D. F., Sellers, G., Joo, J. S., Bruce, C. J., Coller, J. A., Murray, J. J., Schoetz, Jr., D. J., Roberts, P. L., Schoetz, D., Bockler, M., Rosenblatt, M., Malhorta, S., Roberts, P., Murray, J., Coller, J., Rusin, L., Liu, C. D., Newton, T. R., Zinner, M. J., Ashley, S. W., McFadden, D. W., Tusek, D. L., Church, J. M., Strong, S. A., Grass, J., Steinhart, A. H., Greenberg, G. R., Siminovich, K., Blair, J. E., Cruz, C., Prabhakar, L. P., Laramee, C., Nelson, H., Dozois, R. R., Ozuner, G., Hull, T., Fazio, V., Navaro, G., Bauer, J. J., Gorfine, S. R., Gelemt, I. M., Harris, M. T., Kreel, I., Marcello, P. W., Rusin, L. C., Veidenheimer, M. C., Ogunbiyi, O. A., Thibault, C., Sagar, P., Wolff, B. G., Lee, F., Lee, E. C., Pennoyer, W. P., Vignati, P. V., Cohen, J., MacRae, H. M., O'Connor, B., Ton, E., Hain, J. M., Perez-Ramirez, J. J., Spencer, M. P., Gemlo, B. T., Neto, J. A. Reis, Quilici, F. A., Cordeiro, F., Reis, Jr., J. A., Neto, C. I. Reis, Gottesman, L., Tjandra, J., Takano, M., Kuromizu, J., Tsuji, Y., Lee, C. S., Ferrara, A., Levy, J. R., Larach, S. W., Krecker, M., Williamson, P. R., Wong, D. W., Sarmiento, J. M., Burgart, L. J., Frizelle, F. A., Ilstrup, D. M., Salem, R., Smith, L. E., Rooney, P. S., Chapman, M. A. S., Steele, R. J. C., Koren, R., Gal, R., Kyzer, S., Chaimoff, CH., Rodríguez-Bigas, M. A., Mahoney, M. C., Weber, T. K., Petrelli, N. J., Ault, G., Ceron, O., Conti, P., Hadfield, M. B., Turnbull, L. W., Nicholson, A. A., Horsman, A., Shibata, D., Sentovich, S., Hyland, W., Busse, P., Bleday, R., Allendorf, J., Whelan, R., Horvath, K., Treat, M., Wronski, M., Arbit, E., Bilsky, M., Galicich, J. H., Miller, A. S., Lewis, W. G., Williamson, M. E. R., Sagar, P. M., Holdsworth, P. J., Johnston, D., Smith, A. H., Marchetti, F., Thompson-Fawcett, M. W., Warren, B. F., Mortensen, N. J. M., Bouchard, S., Belliveau, P., Trudel, J., Zinsmeister, A. R., Schleck, C. D., McIntyre, P. B., Hanson, R. B., Read, T. E., Dominguez, J. M., Hyman, N. H., Beck, D. E., Dayton, M. T., Stryker, S. J., Wolf, B. G., Young-Fadok, T. M., Meagher, A., Benn, P. L., Takao, Y., Chen, F. C., Wu, J., Milsom, J., Stein, B. L., Vasilevsky, C. A., Hartley, J. E., Cureshi, A., Sellers, G. J., Van, D., Ludwig, K. A., Garcia-Ruiz, A., Espat, N. J., Rao, G. N., Drew, P. J., Pfeifer, J., Park, U. C., Gonzalez, A., Okamoto, T., Konishi, F., Tsukamoto, T., Senba, S., Kashiwagi, H., Kojima, M., Togashi, T., Kanazawa, K., Yoon, W. H., Kang, Y. N., Hong, K. H., Park, H. D., Koo, S. H., Song, K. S., Kim, J. C., Roh, S. A., Park, K. C., Jessup, J. M., Changchien, C. R., Wang, J. Y., Hsu, K. C., Chen, J. S., Tang, R., You, Y. T., Ho, Y. S., Guttman, R., Nelson, R., Sardinha, T. G. S., Gilliland, J., Kroll, M., Lee, E., Wexler, J., Hudzinski, D., Glass, D., Wolff, B. D., King, D. W., Talley, N., Chen, W. S., Lin, W. C., Hsu, H., Wrightson, W. R., Galandiuk, S., LaRocca, R., Myers, S. R., Tada, M., Inoue, H., Tsubaki, M., Endo, M., Sobzcak, S., Welch, J. P., Cohen, J. L., Allen, L. W., Morrow, J. S., Behen, S. L., Smith, K. W., Cali, J. R., Bailey, H. R., Fucini, C., Elbetti, C., Messerini, L., Law, W. L., Butts, D. R., Max, E., Memon, M. A., Devine, J., Feeney, J., Talley, N. J., Stephenson, E. R., Ilahi, O., Koltun, W. A., Spellman, M., Rantis, R. C., Vernava, A. M., Parra, R. O., Breen, E., Hayes, P., Quinn, D., Whitlow, C. B., Opelka, F. G., Gathright, J. B., Golub, R. W., Maccabee, P. J., Combs, A. J., Grose, E. A., Taylor, B. M., Kozell, K., McGannon, E., Krogh, K., Nielsen, J., Djurhuus, J. C., Mosdal, C., Sabroe, S., Laurberg, S., Chen, M. F., Kerner, B. A., Khanduja, K. S., Wise, Jr., W. E., Padmanabhan, A., Meesig, D. M., Yasin, M. T., Aguilar, P. S., Ho, Y. H., Tan, M., Seow-Choen, F., Rustin, R. B., and Harmon, J. M.

Published
1996
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28. Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats

Author

Glover, M. E., Clinton, S. M., Jackson, N. L., Cohen, J. L., Akil, H., Pugh, P. C., and Fant, A. D.

Subjects
digestive, oral, and skin physiology
Abstract

Selective serotonin reuptake inhibitor (SSRI) antidepressants are the mainstay treatment for the 10–20% of pregnant and postpartum women who suffer major depression, but the effects of SSRIs on their children’s developing brain and later emotional health are poorly understood. SSRI use during pregnancy can elicit antidepressant withdrawal in newborns and increase toddlers’ anxiety and social avoidance. In rodents, perinatal SSRI exposure increases adult depression- and anxiety-like behavior, although certain individuals are more vulnerable to these effects than others. Our study establishes a rodent model of individual differences in susceptibility to perinatal SSRI exposure, utilizing selectively-bred Low Responder (bLR) and High Responder (bHR) rats that were previously bred for high versus low behavioral response to novelty. Pregnant bHR/bLR females were chronically treated with the SSRI paroxetine (10 mg/kg/day p.o.) to examine its effects on offspring’s emotional behavior and gene expression in the developing brain. Paroxetine treatment had minimal effect on bHR/bLR dams’ pregnancy outcomes or maternal behavior. We found that bLR offspring, naturally prone to an inhibited/anxious temperament, were susceptible to behavioral abnormalities associated with perinatal SSRI exposure (which exacerbated their Forced Swim test immobility), while high risk-taking bHR offspring were resistant. Microarray studies revealed robust perinatal SSRI-induced gene expression changes in the developing bLR hippocampus and amygdala (postnatal days 7–21), including transcripts involved in neurogenesis, synaptic vesicle components, and energy metabolism. These results highlight the bLR/bHR model as a useful tool to explore the neurobiology of individual differences in susceptibility to perinatal SSRI exposure.

Published
2015
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29. Treatment-induced remission of medulloblastoma using a chemotherapeutic regimen devoid of vincristine in a child with Charcot-Marie-Tooth disease.

Author

Bernstock, J. D., Cohen, J. L., Singh, S., Schlappi, C. W., Fiveash, J. B., Johnston, J. M., Fequiere, P., Orr, B. A., Li, R., and Friedman, G. K.

Subjects
*CHARCOT-Marie-Tooth disease, *JUVENILE diseases, *CEREBELLAR tumors, *THERAPEUTICS, *PERIPHERAL neuropathy, *DRUG utilization
Abstract

Charcot-Marie-Tooth (cmt) disease is the most common form of inherited neuropathy. Core features include peripheral neuropathy and secondary axonal degeneration, with a noted distal predominance of limb-muscle wasting, weakness, and sensory loss. Given the significant prevalence of cmt, superimposed neoplastic disease can be encountered within this patient population. Malignancies that are treated with vincristine (a microtubule-targeting agent), even at low doses as part of standard treatment, pose a significant challenge for patients with cmt. Here, we present the case of a child with cmt who was successfully treated for medulloblastoma without vincristine, a standard drug used for treatment of that disease, to avoid the risk of severe debilitating neuropathy. This report is the first of a patient successfully treated for medulloblastoma without vincristine. [ABSTRACT FROM AUTHOR]

Published
2019
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31. Consiglio scientifico della rivista 'Rassegna di Architettura e Urbanistica'

Author

Argenti, Maria, Barbera, Lucio, Ciucci, G., Cohen, J. L., Colarossi, Paolo, Conforti, C., De Martino, U., Garofalo, F., Irace, F., Kieven, E., Melograni, C., Moschini, F., Muntoni, Alessandra, Olmo, C., Piroddi, Elio, Poretti, S., Purini, Francesco, Rossi, Piero Ostilio, and Rotondi, S.

Published
2011

32. Filtered Talbot lens: Producing $��/2n$-periodic atomic patterns with standing wave fields having period $��$

Author

Cohen, J. L., Dubetsky, B., Berman, P. R., and Schmiedmayer, J.

Subjects
Condensed Matter::Quantum Gases, Atomic Physics (physics.atom-ph), Physics::Atomic and Molecular Clusters, Physics::Optics, FOS: Physical sciences, Physics::Atomic Physics
Abstract

We propose a scheme to create high-contrast, periodic atom density distributions having period $��/2n$ using the Talbot effect, where $% ��$ is the wave length of the optical fields that scatter the atoms and $n$ is a positive integer. This {\em filtered Talbot lens} is comprised of two standing-wave optical fields. An atomic beam propagates perpendicular to the fields. The first field, which is far-detuned from the atomic transition frequency, acts as an array of lenses that focuses the atoms. The second field, positioned at the atom optical focus of the first, is resonant with the atomic transition frequency and acts as an amplitude mask, leaving unperturbed only those atoms that pass through its nodes. At distances following the interaction with the second field that are equal to an integral fraction of the Talbot length, atomic density gratings having period $��/2n$ are formed., 7 pages, 3 figures

Published
1999
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45. Transcriptomic Signature of the CD24hiCD38hiTransitional B Cells Associated With an Immunoregulatory Phenotype in Renal Transplant Recipients

Author

Bigot, J., Pilon, C., Matignon, M., Grondin, C., Leibler, C., Aissat, A., Pirenne, F., Cohen, J. L., and Grimbert, P.

Abstract

The role of B cells after transplant regarding allograft rejection or tolerance has become a topic of major interest. Recently, in renal transplant recipients, a B cell signature characterized by the overexpression of CD19+CD38hiCD24hitransitional B cells has been observed in operationally tolerant patients and in belatacept‐treated patients with significantly lower incidence of donor‐specific antibodies. The phenotypic and functional characterization of these transitional B cells is far from exhaustive. We present the first transcriptomic and phenotypic analysis associated with this cell phenotype. Three populations were studied and compared: (i) transitional CD24hiCD38hi, (ii) CD24+CD38−, and (iii) CD24intCD38intB cells. Transcriptome bioinformatic analysis revealed a particular signature for the CD24hiCD38hipopulation. Phenotypic analysis showed that CD24hiCD38hitransitional B cells also expressed CD9, CD10, CD1b and inducible T cell costimulator ligand (ICOS‐L) markers. In addition, we found enrichment of IL‐10+cells among CD24hiCD38hicells expressing ICOS‐L and CD1b, the latter showing regulatory properties. Renal transplant recipients treated with belatacept exhibited significant expression of CD1b. Our results show that transitional CD24hiCD38hiB cells exhibit a distinct and specific profile, and this could be helpful for understanding of immune‐regulatory mechanisms and immune monitoring in the field of organ transplant and autoimmune disease. This study highlights a specific transcriptomic and phenotypic signature of human transitional CD24hiCD38hiB cells associated with immunoregulatory properties.

Published
2016
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