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3,664 results on '"Cohen, David J"'

3. C3 Glomerulopathy Recurs Early after Kidney Transplantation in Serial Biopsies Performed within the First Two Years Post-Transplantation

Author

Tarragón, Blanca, Peleg, Yonatan, Jagannathan, Geetha, Sekulic, Miroslav, Chang, Jae-Hyung, Cohen, David J, Crew, Russell J, Dube, Geoffrey K, Fernandez, Hilda E, Husain, Syed Ali, Mohan, Sumit, Morris, Heather K, Appel, Gerald, Jadav, Paresh, Santoriello, Dominick, Kudose, Satoru, Stokes, M Barry, Batal, Ibrahim, and Bomback, Andrew

Published
2024
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4. Does the Effectiveness of a Medicine Copay Voucher Vary by Baseline Medication Out‐Of‐Pocket Expenses? Insights From ARTEMIS

Author

Rymer, Jennifer A, Kaltenbach, Lisa A, Peterson, Eric D, Cohen, David J, Fonarow, Gregg C, Choudhry, Niteesh K, Henry, Timothy D, Cannon, Christopher P, and Wang, Tracy Y

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cost Effectiveness Research, Heart Disease - Coronary Heart Disease, Cardiovascular, Heart Disease, Good Health and Well Being, Humans, Health Expenditures, Medication Adherence, Myocardial Infarction, Purinergic P2Y Receptor Antagonists, Treatment Outcome, copay, myocardial infarction, persistence, voucher, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
Abstract

Background Persistence to P2Y12 inhibitors after myocardial infarction (MI) remains low. Out-of-pocket cost is cited as a factor affecting medication compliance. We examined whether a copayment intervention affected 1-year persistence to P2Y12 inhibitors and clinical outcomes. Methods and Results In an analysis of ARTEMIS (Affordability and Real-World Antiplatelet Treatment Effectiveness After Myocardial Infarction Study), patients with MI discharged on a P2Y12 inhibitor were stratified by baseline out-of-pocket medication burden: low ($0-$49 per month), intermediate ($50-$149 per month), and high (≥$150 per month). The impact of the voucher intervention on 1-year P2Y12 inhibitor persistence was examined using a logistic regression model with generalized estimating equations. We assessed the rates of major adverse cardiovascular events among the groups using a Kaplan-Meier estimator. Among 7351 MI-treated patients at 282 hospitals, 54.2% patients were in the low copay group, 32.0% in the middle copay group, and 13.8% in the high copay group. Patients in higher copay groups were more likely to have a history of prior MI, heart failure, and diabetes compared with the low copay group (all P

Published
2022

5. Clinical outcomes among patients with mitral valve regurgitation undergoing Impella-supported high-risk PCI

Author

Abu-Much, Arsalan, Grines, Cindy L., Chen, Shmuel, Batchelor, Wayne B., Zhao, Duzhi, Falah, Batla, Maini, Aneel S., Redfors, Björn, Bellumkonda, Lavanya, Bharadwaj, Aditya S., Moses, Jeffrey W., Truesdell, Alexander G., Zhang, Yiran, Zhou, Zhipeng, Baron, Suzanne J., Lansky, Alexandra J., Basir, Mir B., O'Neill, William W., and Cohen, David J.

Published
2024
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6. Neutrophil‐to‐Lymphocyte Ratios in Patients Undergoing Aortic Valve Replacement: The PARTNER Trials and Registries

Author

Shahim, Bahira, Redfors, Björn, Lindman, Brian R, Chen, Shmuel, Dahlen, Torsten, Nazif, Tamim, Kapadia, Samir, Gertz, Zachary M, Crowley, Aaron C, Li, Ditian, Thourani, Vinod H, Kodali, Susheel K, Zajarias, Alan, Babaliaros, Vasilis C, Guyton, Robert A, Elmariah, Sammy, Herrmann, Howard C, Cohen, David J, Mack, Michael J, Smith, Craig R, Leon, Martin B, and George, Isaac

Subjects
Heart Disease, Clinical Research, Transplantation, Cardiovascular, Aortic Valve, Aortic Valve Stenosis, Heart Valve Prosthesis Implantation, Humans, Lymphocytes, Neutrophils, Registries, Risk Factors, Severity of Illness Index, Treatment Outcome, aortic stenosis, neutrophil-to-lymphocyte ratio, NLR, surgical aortic valve replacement, transcatheter aortic valve replacement, neutrophil‐to‐lymphocyte ratio, Cardiorespiratory Medicine and Haematology
Abstract

Background The neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic inflammation has been associated with worse prognosis in several chronic disease states, including heart failure. However, few data exist on the prognostic impact of elevated baseline NLR or change in NLR levels during follow-up in patients undergoing transcatheter or surgical aortic valve replacement (TAVR or SAVR) for aortic stenosis. Methods and Results NLR was available in 5881 patients with severe aortic stenosis receiving TAVR or SAVR in PARTNER (Placement of Aortic Transcatheter Valves) I, II, and S3 trials/registries (median [Q1, Q3] NLR, 3.30 [2.40, 4.90]); mean NLR, 4.10; range, 0.5-24.9) and was evaluated as continuous variable and categorical tertiles (low: NLR ≤2.70, n=1963; intermediate: NLR 2.70-4.20, n=1958; high: NLR ≥4.20, n=1960). No patients had known baseline infection. High baseline NLR was associated with increased risk of death or rehospitalization at 3 years (58.4% versus 41.0%; adjusted hazard ratio [aHR], 1.39; 95% CI, 1.18-1.63; P

Published
2022

10. Ticagrelor with or without aspirin following percutaneous coronary intervention in high-risk patients with concomitant peripheral artery disease: A subgroup analysis of the TWILIGHT randomized clinical trial

Author

Krucoff, Mitchell, Spirito, Alessandro, Baber, Usman, Sartori, Samantha, Angiolillo, Dominick J., Briguori, Carlo, Cohen, David J., Collier, Timothy, Dangas, George, Dudek, Dariusz, Escaned, Javier, Gibson, C. Michael, Han, Ya-Ling, Huber, Kurt, Kastrati, Adnan, Kaul, Upendra, Kornowski, Ran, Kunadian, Vijay, Vogel, Birgit, Mehta, Shamir R., Moliterno, David, Sardella, Gennaro, Shlofmitz, Richard A., Sharma, Samin, Steg, Philippe Gabriel, Pocock, Stuart, and Mehran, Roxana

Published
2024
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12. Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

Author

Gupta, Yask, Friedman, David J., McNulty, Michelle T., Khan, Atlas, Lane, Brandon, Wang, Chen, Ke, Juntao, Jin, Gina, Wooden, Benjamin, Knob, Andrea L., Lim, Tze Y., Appel, Gerald B., Huggins, Kinsie, Liu, Lili, Mitrotti, Adele, Stangl, Megan C., Bomback, Andrew, Westland, Rik, Bodria, Monica, Marasa, Maddalena, Shang, Ning, Cohen, David J., Crew, Russell J., Morello, William, Canetta, Pietro, Radhakrishnan, Jai, Martino, Jeremiah, Liu, Qingxue, Chung, Wendy K., Espinoza, Angelica, Luo, Yuan, Wei, Wei-Qi, Feng, Qiping, Weng, Chunhua, Fang, Yilu, Kullo, Iftikhar J., Naderian, Mohammadreza, Limdi, Nita, Irvin, Marguerite R., Tiwari, Hemant, Mohan, Sumit, Rao, Maya, Dube, Geoffrey K., Chaudhary, Ninad S., Gutiérrez, Orlando M., Judd, Suzanne E., Cushman, Mary, Lange, Leslie A., Lange, Ethan M., Bivona, Daniel L., Verbitsky, Miguel, Winkler, Cheryl A., Kopp, Jeffrey B., Santoriello, Dominick, Batal, Ibrahim, Pinheiro, Sérgio Veloso Brant, Oliveira, Eduardo Araújo, Simoes e Silva, Ana Cristina, Pisani, Isabella, Fiaccadori, Enrico, Lin, Fangming, Gesualdo, Loreto, Amoroso, Antonio, Ghiggeri, Gian Marco, D’Agati, Vivette D., Magistroni, Riccardo, Kenny, Eimear E., Loos, Ruth J. F., Montini, Giovanni, Hildebrandt, Friedhelm, Paul, Dirk S., Petrovski, Slavé, Goldstein, David B., Kretzler, Matthias, Gbadegesin, Rasheed, Gharavi, Ali G., Kiryluk, Krzysztof, Sampson, Matthew G., Pollak, Martin R., and Sanna-Cherchi, Simone

Published
2023
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22. Predicting the EQ-5D utilities from the Kansas City Cardiomyopathy Questionnaire in patients with heart failure

Author

Thomas, Merrill, Jones, Philip G, Cohen, David J, Suzanne, Arnold V, Magnuson, Elizabeth A, Wang, Kaijun, Thourani, Vinod H, Fonarow, Gregg C, Sandhu, Alexander T, and Spertus, John A

Subjects
Cardiovascular, Clinical Research, Heart Disease, Good Health and Well Being, Cardiomyopathies, Heart Failure, Humans, Kansas, Quality of Life, Stroke Volume, Surveys and Questionnaires, Health economics, Health status, Utilities
Abstract

IntroductionEvaluation of health status benefits, cost-effectiveness, and value of new heart failure therapies is critical for supporting their use. The Kansas City Cardiomyopathy Questionnaire (KCCQ) measures patients' heart failure-specific health status but does not provide utilities needed for cost-effectiveness analyses. We mapped the KCCQ scores to EQ-5D scores so that estimates of societal-based utilities can be generated to support economic analyses.MethodsUsing data from two US cohort studies, we developed models for predicting EQ-5D utilities (3L and 5L versions) from the KCCQ (23- and 12-item versions). In addition to predicting scores directly, we considered predicting the five EQ-5D health state items and deriving utilities from the predicted responses, allowing different countries' health state valuations to be used. Model validation was performed internally via bootstrap and externally using data from two clinical trials. Model performance was assessed using R2, mean prediction error, mean absolute prediction error, and calibration of observed vs. predicted values.ResultsThe EQ-5D-3L models were developed from 1000 health status assessments in 547 patients with heart failure and reduced ejection fraction (HFrEF), while the EQ-5D-5L model was developed from 3925 patients with HFrEF. For both versions, models predicting individual EQ-5D items performed as well as those predicting utilities directly. The selected models for the 3L had internally validated R2 of 48.4-50.5% and 33.7-45.6% on external validation. The 5L version had validated R2 of 57.7%.ConclusionMappings from the KCCQ to the EQ-5D can yield the estimates of societal-based utilities to support cost-effectiveness analyses when EQ-5D data are not available.

Published
2021

23. Clinically Driven Revascularization in High-Risk Patients Treated With Ticagrelor Monotherapy After PCI: Insights from the Randomized TWILIGHT Trial

Author

Baber, Usman, Spirito, Alessandro, Sartori, Samantha, Angiolillo, Dominick J., Briguori, Carlo, Cohen, David J., Collier, Timothy, Dangas, George, Dudek, Dariusz, Escaned, Javier, Gibson, C. Michael, Han, Ya-Ling, Huber, Kurt, Kastrati, Adnan, Kaul, Upendra, Kornowski, Ran, Krucoff, Mitchell, Kunadian, Vijay, Vogel, Birgit, Mehta, Shamir R., Moliterno, David, Sardella, Gennaro, Shlofmitz, Richard A., Sharma, Samin, Steg, Philippe Gabriel, Pocock, Stuart, and Mehran, Roxana

Published
2023
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24. The Mortality Burden of Untreated Aortic Stenosis

Author

Généreux, Philippe, Sharma, Rahul P., Cubeddu, Robert J., Aaron, Lucy, Abdelfattah, Omar M., Koulogiannis, Konstantinos P., Marcoff, Leo, Naguib, Mostafa, Kapadia, Samir R., Makkar, Rajendra R., Thourani, Vinod H., van Boxtel, Benjamin S., Cohen, David J., Dobbles, Michael, Barnhart, Glenn R., Kwon, Michelle, Pibarot, Philippe, Leon, Martin B., and Gillam, Linda D.

Published
2023
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26. Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints

Author

Arnold, Suzanne, Bapat, Vinayak, Berry, Natalia, Blanke, Philipp, Burkhoff, Daniel, Coylewright, Megan, Duggal, Neal, Galper, Benjamin, George, Isaac, Guerrero, Mayra, Hamid, Nadira, Jagadeesan, Vikrant, Kodali, Susheel, Krucoff, Mitch, Lang, Roberto, Madhavan, Mahesh, McLaughin, Vallerie, Mehran, Roxana, Philippon, Francois, Sethi, Sanjum S., Simonato, Matheus, Smith, Robert, Sodhi, Nishtha, Spertus, John, Stocker, Thomas J., Stone, Gregg, Hahn, Rebecca T., Lawlor, Matthew K., Davidson, Charles J., Badhwar, Vinay, Sannino, Anna, Spitzer, Ernest, Lurz, Philipp, Lindman, Brian R., Topilsky, Yan, Baron, Suzanne J., Chadderdon, Scott, Khalique, Omar K., Tang, Gilbert H.L., Taramasso, Maurizio, Grayburn, Paul A., Badano, Luigi, Leipsic, Jonathon, Lindenfeld, JoAnn, Windecker, Stephan, Vemulapalli, Sreekanth, Redfors, Bjorn, Alu, Maria C., Cohen, David J., Rodés-Cabau, Josep, Ailawadi, Gorav, Mack, Michael, Ben-Yehuda, Ori, Leon, Martin B., and Hausleiter, Jörg

Published
2023
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27. Dyspnea-Related Ticagrelor Discontinuation After Percutaneous Coronary Intervention

Author

Angiolillo, Dominick J., Cao, Davide, Sartori, Samantha, Baber, Usman, Dangas, George, Zhang, Zhongjie, Vogel, Birgit, Kunadian, Vijay, Briguori, Carlo, Cohen, David J., Collier, Timothy, Dudek, Dariusz, Gibson, Michael, Gil, Robert, Huber, Kurt, Kaul, Upendra, Kornowski, Ran, Krucoff, Mitchell W., Ielasi, Alfonso, Stefanini, Giulio G., Pivato, Carlo A., Mehta, Shamir, Moliterno, David J., Ohman, E. Magnus, Escaned, Javier, Sardella, Gennaro, Sharma, Samin K., Shlofmitz, Richard, Weisz, Giora, Witzenbichler, Bernhard, Steg, P. Gabriel, Pocock, Stuart, and Mehran, Roxana

Published
2023
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28. Analysis of Adverse Events Related to Impella Usage (from the Manufacturer and User Facility Device Experience and National Inpatient Sample Databases).

Author

Philipson, Daniel J, Cohen, David J, Fonarow, Gregg C, and Ziaeian, Boback

Subjects
Humans, Shock, Cardiogenic, Postoperative Complications, Heart-Assist Devices, Incidence, Hospital Mortality, Survival Rate, Risk Factors, Retrospective Studies, Follow-Up Studies, Equipment Failure, Databases, Factual, Inpatients, United States, Cardiovascular System & Hematology, Cardiorespiratory Medicine and Haematology
Abstract

Impella devices are increasingly utilized for hemodynamic support in high-risk percutaneous coronary intervention or cardiogenic shock despite a lack of randomized clinical trial data showing clinical benefit and newer observational data suggesting harm. In this retrospective analysis, our aim was to determine the most common adverse events associated with Impella usage reported annually to the Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) database and to estimate via the National Inpatient Sample (NIS) database the number of percutaneous ventricular assist devices utilized and associated with inpatient mortality since introduction of the Impella. Among the 885 complete reports submitted to the MAUDE database from 2008 to 2019 related to Impella usage, there were 1,206 complications coded; 88.2% of reports occurred from 2016 to 2019. Among patients with adverse events reported, bleeding (32.8%), device deployment or retrieval issues (18.2%), vascular complications (15.8%), and death (12.4%) were the most common, and 7.9% of all complications were attributable to operator decision-making or technique. From 2007 to 2017 there was a >100-fold increase in percutaneous ventricular assist devices use with an increase and plateau in in-hospital mortality to 31% from 2012 to 2016 based on NIS data. In conclusion, Impella use has increased substantially over the last decade but remains associated with high inpatient mortality and serious complications based on data from the NIS and MAUDE databases. These findings emphasize the need for high quality randomized controlled trials to determine the clinical utility of Impella in high-risk percutaneous coronary intervention and cardiogenic shock.

Published
2021

29. Biolimus-eluting vs. other limus-eluting stents in NSTE-ACS: A pooled analysis of GLASSY and TWILIGHT

Author

Spirito, Alessandro, Valgimigli, Marco, Cao, Davide, Baber, Usman, Mehta, Shamir R., Gibson, C. Michael, Steg, Gabriel P., Sharma, Samin K., Goel, Ridhima, Huber, Kurt, Kunadian, Vijay, Escaned, Javier, Franzone, Anna, Yaling, Han, Collier, Timothy, Kaul, Upendra, Kornowski, Ran, Krucoff, Mitchell, Moliterno, David, Sartori, Samantha, Owen, Ruth, Zhang, Zhongjie, Dangas, George D., Kastrati, Adnan, Angiolillo, Dominick J., Cohen, David J., Vranckx, Pascal, Windecker, Stephan, Pocock, Stuart, and Mehran, Roxana

Published
2023
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37. Severity of and Recovery From Anemia After Transcatheter Aortic Valve Replacement: An Analysis of the PARTNER Trials and Registries

Author

Bhardwaj, Bhaskar, Kolte, Dhaval, Zhao, Yanglu, Alu, Maria C., Zahr, Firas, Passeri, Jonathan J., Inglessis, Ignacio, Vlahakes, Gus J., Garcia, Santiago, Cohen, David J., Makkar, Raj R., Kodali, Susheel, Thourani, Vinod H., Kapadia, Samir, Palacios, Igor F., Leon, Martin B., Smith, Craig R., Mack, Michael J., and Elmariah, Sammy

Published
2023
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44. Transcatheter Mitral Valve Replacement Versus Medical Therapy for Secondary Mitral Regurgitation: A Propensity Score–Matched Comparison

Author

Ludwig, Sebastian, Conradi, Lenard, Cohen, David J., Coisne, Augustin, Scotti, Andrea, Abraham, William T., Ben Ali, Walid, Zhou, Zhipeng, Li, Yanru, Kar, Saibal, Duncan, Alison, Lim, D. Scott, Adamo, Marianna, Redfors, Björn, Muller, David W.M., Webb, John G., Petronio, Anna S., Ruge, Hendrik, Nickenig, Georg, Sondergaard, Lars, Adam, Matti, Regazzoli, Damiano, Garatti, Andrea, Schmidt, Tobias, Andreas, Martin, Dahle, Gry, Walther, Thomas, Kempfert, Joerg, Tang, Gilbert H.L., Redwood, Simon, Taramasso, Maurizio, Praz, Fabien, Fam, Neil, Dumonteil, Nicolas, Obadia, Jean-François, von Bardeleben, Ralph Stephan, Rudolph, Tanja K., Reardon, Michael J., Metra, Marco, Denti, Paolo, Mack, Michael J., Hausleiter, Jörg, Asch, Federico M., Latib, Azeem, Lindenfeld, JoAnn, Modine, Thomas, Stone, Gregg W., and Granada, Juan F.

Published
2023
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45. Rare Single Nucleotide and Copy Number Variants and the Etiology of Congenital Obstructive Uropathy: Implications for Genetic Diagnosis

Author

Ahram, Dina F., Lim, Tze Y., Ke, Juntao, Jin, Gina, Verbitsky, Miguel, Bodria, Monica, Kil, Byum Hee, Chatterjee, Debanjana, Piva, Stacy E., Marasa, Maddalena, Zhang, Jun Y., Cocchi, Enrico, Caridi, Gianluca, Gucev, Zoran, Lozanovski, Vladimir J., Pisani, Isabella, Izzi, Claudia, Savoldi, Gianfranco, Gnutti, Barbara, Capone, Valentina P., Morello, William, Guarino, Stefano, Esposito, Pasquale, Lambert, Sarah, Radhakrishnan, Jai, Appel, Gerald B., Uy, Natalie S., Rao, Maya K., Canetta, Pietro A., Bomback, Andrew S., Nestor, Jordan G., Hays, Thomas, Cohen, David J., Finale, Carolina, Wijk, Joanna A.E. van, La Scola, Claudio, Baraldi, Olga, Tondolo, Francesco, Di Renzo, Dacia, Jamry-Dziurla, Anna, Pezzutto, Alessandro, Manca, Valeria, Mitrotti, Adele, Santoro, Domenico, Conti, Giovanni, Martino, Marida, Giordano, Mario, Gesualdo, Loreto, Zibar, Lada, Masnata, Giuseppe, Bonomini, Mario, Alberti, Daniele, La Manna, Gaetano, Caliskan, Yasar, Ranghino, Andrea, Marzuillo, Pierluigi, Kiryluk, Krzysztof, Krzemień, Grażyna, Miklaszewska, Monika, Lin, Fangming, Montini, Giovanni, Scolari, Francesco, Fiaccadori, Enrico, Arapović, Adela, Saraga, Marijan, McKiernan, James, Alam, Shumyle, Zaniew, Marcin, Szczepańska, Maria, Szmigielska, Agnieszka, Sikora, Przemysław, Drożdż, Dorota, Mizerska-Wasiak, Malgorzata, Mane, Shrikant, Lifton, Richard P., Tasic, Velibor, Latos-Bielenska, Anna, Gharavi, Ali G., Ghiggeri, Gian Marco, Materna-Kiryluk, Anna, Westland, Rik, and Sanna-Cherchi, Simone

Published
2023
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46. Evolution and Prognostic Impact of Cardiac Damage After Aortic Valve Replacement

Author

Généreux, Philippe, Pibarot, Philippe, Redfors, Björn, Bax, Jeroen J., Zhao, Yanglu, Makkar, Raj R., Kapadia, Samir, Thourani, Vinod H., Mack, Michael J., Nazif, Tamim M., Lindman, Brian R., Babaliaros, Vasilis, Vincent, Flavien, Russo, Mark, McCabe, James M., Gillam, Linda D., Alu, Maria C., Hahn, Rebecca T., Webb, John G., Leon, Martin B., and Cohen, David J.

Published
2022
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47. Deep Learning Electrocardiographic Analysis for Detection of Left-Sided Valvular Heart Disease

Author

Elias, Pierre, Poterucha, Timothy J., Rajaram, Vijay, Moller, Luca Matos, Rodriguez, Victor, Bhave, Shreyas, Hahn, Rebecca T., Tison, Geoffrey, Abreau, Sean A., Barrios, Joshua, Torres, Jessica Nicole, Hughes, J. Weston, Perez, Marco V., Finer, Joshua, Kodali, Susheel, Khalique, Omar, Hamid, Nadira, Schwartz, Allan, Homma, Shunichi, Kumaraiah, Deepa, Cohen, David J., Maurer, Mathew S., Einstein, Andrew J., Nazif, Tamim, Leon, Martin B., and Perotte, Adler J.

Published
2022
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48. Sex-Related Differences in Medically Treated Moderate Aortic Stenosis

Author

Stassen, Jan, Pio, Stephan M., Ewe, See Hooi, Amanullah, Mohammed R., Hirasawa, Kensuke, Butcher, Steele C., Singh, Gurpreet K., Sin, Kenny Y.K., Ding, Zee P., Chew, Nicholas W.S., Sia, Ching-Hui, Kong, William K.F., Poh, Kian Keong, Cohen, David J., Généreux, Philippe, Leon, Martin B., Marsan, Nina Ajmone, Delgado, Victoria, and Bax, Jeroen J.

Published
2022
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