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A novel two-qubit entangling gate for RF-controlled trapped-ion quantum processors is proposed theoretically and demonstrated experimentally. The speed of this gate is an order of magnitude higher than that of previously demonstrated two-qubit entangling gates in static magnetic field gradients. At the same time, the phase-modulated field driving the gate, dynamically decouples the qubits from amplitude and frequency noise, increasing the qubits' coherence time by two orders of magnitude. The gate requires only a single continuous RF field per qubit, making it well suited for scaling a quantum processor to large numbers of qubits. Implementing this entangling gate, we generate the Bell states $|\Phi^+\rangle$ and $|\Psi^+\rangle$ in $\leq 313$ $\mathrm{\mathrm{\mu}}$s with fidelities up to $98^{+2}_{-3}$ % in a static magnetic gradient of only 19.09 T/m. At higher magnetic field gradients, the entangling gate speed can be further improved to match that of laser-based counterparts.

In search settings, calibrating the scores during the ranking process to quantities such as click-through rates or relevance levels enhances a system's usefulness and trustworthiness for downstream users. While previous research has improved this notion of calibration for low complexity learning-to-rank models, the larger data demands and parameter count specific to modern neural text rankers produce unique obstacles that hamper the efficacy of methods intended for the learning-to-rank setting. This paper proposes exploiting large language models (LLMs) to provide relevance and uncertainty signals for these neural text rankers to produce scale-calibrated scores through Monte Carlo sampling of natural language explanations (NLEs). Our approach transforms the neural ranking task from ranking textual query-document pairs to ranking corresponding synthesized NLEs. Comprehensive experiments on two popular document ranking datasets show that the NLE-based calibration approach consistently outperforms past calibration methods and LLM-based methods for ranking, calibration, and query performance prediction tasks.

By allowing models to predict without task-specific training, in-context learning (ICL) with pretrained LLMs has enormous potential in NLP. However, a number of problems persist in ICL. In particular, its performance is sensitive to the choice and order of in-context examples. Given the same set of in-context examples with different orderings, model performance may vary between near random to near state-of-the-art. In this work, we formulate in-context example ordering as an optimization problem. We examine three problem settings that differ in the assumptions they make about what is known about the task. Inspired by the idea of learning from label proportions, we propose two principles for in-context example ordering guided by model's probability predictions. We apply our proposed principles to thirteen text classification datasets and nine different autoregressive LLMs with 700M to 13B parameters. We demonstrate that our approach outperforms the baselines by improving the classification accuracy, reducing model miscalibration, and also by selecting better in-context examples., Comment: preprint

Epithelial monolayers are some of the best-studied models for collective cell migration due to their abundance in multicellular systems and their tractability. Experimentally, the collective migration of epithelial monolayers can be robustly steered e.g. using electric fields, via a process termed electrotaxis. Theoretically, however, the question of how to design an electric field to achieve a desired spatiotemporal movement pattern is underexplored. In this work, we construct and calibrate an ordinary differential equation model to predict the average velocity of the centre of mass of a cellular monolayer in response to stimulation with an electric field. We use this model, in conjunction with optimal control theory, to derive physically realistic optimal electric field designs to achieve a variety of aims, including maximising the total distance travelled by the monolayer, maximising the monolayer velocity, and keeping the monolayer velocity constant during stimulation. Together, this work is the first to present a unified framework for optimal control of collective monolayer electrotaxis and provides a blueprint to optimally steer collective migration using other external cues.

The spatiotemporal coordination and regulation of cell proliferation is fundamental in many aspects of development and tissue maintenance. Cells have the ability to adapt their division rates in response to mechanical constraints, yet we do not fully understand how cell proliferation regulation impacts cell migration phenomena. Here, we present a minimal continuum model of cell migration with cell cycle dynamics, which includes density-dependent effects and hence can account for cell proliferation regulation. By combining minimal mathematical modelling, Bayesian inference, and recent experimental data, we quantify the impact of tissue crowding across different cell cycle stages in epithelial tissue expansion experiments. Our model suggests that cells sense local density and adapt cell cycle progression in response, during G1 and the combined S/G2/M phases, providing an explicit relationship between each cell cycle stage duration and local tissue density, which is consistent with several experimental observations. Finally, we compare our mathematical model predictions to different experiments studying cell cycle regulation and present a quantitative analysis on the impact of density-dependent regulation on cell migration patterns. Our work presents a systematic approach for investigating and analysing cell cycle data, providing mechanistic insights into how individual cells regulate proliferation, based on population-based experimental measurements.

Societal biases that are contained in retrieved documents have received increased interest. Such biases, which are often prevalent in the training data and learned by the model, can cause societal harms, by misrepresenting certain groups, and by enforcing stereotypes. Mitigating such biases demands algorithms that balance the trade-off between maximized utility for the user with fairness objectives, which incentivize unbiased rankings. Prior work on bias mitigation often assumes that ranking scores, which correspond to the utility that a document holds for a user, can be accurately determined. In reality, there is always a degree of uncertainty in the estimate of expected document utility. This uncertainty can be approximated by viewing ranking models through a Bayesian perspective, where the standard deterministic score becomes a distribution. In this work, we investigate whether uncertainty estimates can be used to decrease the amount of bias in the ranked results, while minimizing loss in measured utility. We introduce a simple method that uses the uncertainty of the ranking scores for an uncertainty-aware, post hoc approach to bias mitigation. We compare our proposed method with existing baselines for bias mitigation with respect to the utility-fairness trade-off, the controllability of methods, and computational costs. We show that an uncertainty-based approach can provide an intuitive and flexible trade-off that outperforms all baselines without additional training requirements, allowing for the post hoc use of this approach on top of arbitrary retrieval models.

Social science often relies on surveys of households and individuals. Dozens of such surveys are regularly administered by the U.S. government. However, they field independent, unconnected samples with specialized questions, limiting research questions to those that can be answered by a single survey. The fusionACS project seeks to integrate data from multiple U.S. household surveys by statistically "fusing" variables from "donor" surveys onto American Community Survey (ACS) microdata. This results in an integrated microdataset of household attributes and well-being dimensions that can be analyzed to address research questions in ways that are not currently possible. The presented data comprise the fusion onto the ACS of select donor variables from the Residential Energy Consumption Survey (RECS) of 2015, the National Household Transportation Survey (NHTS) of 2017, the American Housing Survey (AHS) of 2019, and the Consumer Expenditure Survey - Interview (CEI) for the years 2015-2019. The underlying statistical techniques are included in an open-source $R$ package, fusionModel, that provides generic tools for the creation, analysis, and validation of fused microdata., Comment: 35 pages, 6 figures

When employing mechanistic models to study biological phenomena, practical parameter identifiability is important for making accurate predictions across wide range of unseen scenarios, as well as for understanding the underlying mechanisms. In this work we use a profile likelihood approach to investigate parameter identifiability for four extensions of the Fisher--KPP model, given experimental data from a cell invasion assay. We show that more complicated models tend to be less identifiable, with parameter estimates being more sensitive to subtle differences in experimental procedures, and that they require more data to be practically identifiable. As a result, we suggest that parameter identifiability should be considered alongside goodness-of-fit and model complexity as criteria for model selection., Comment: 20 pages in main text, 22 pages in supplementary materials. Submitted to Journal of Royal Society Interface

Dynamical decoupling is effective in reducing gate errors in most quantum computation platforms and is therefore projected to play an essential role in future fault-tolerant constructions. In superconducting circuits, however, it has proven difficult to utilize the benefits of dynamical decoupling. In this work, we present a theoretical proposal that incorporates a continuous version of dynamical decoupling, namely spin locking, with a coupler-based CZ gate for transmons and provide analytical and numerical results that demonstrate its effectiveness.

Diffusion noise represents a major constraint to successful liquid state nano-NMR spectroscopy. Using the Fisher information as a faithful measure, we theoretically calculate and experimentally show that phase sensitive protocols are superior in most experimental scenarios, as they maximize information extraction from correlations in the sample. We derive the optimal experimental parameters for quantum heterodyne detection (Qdyne) and present the most accurate statistically polarized nano-NMR Qdyne detection experiments to date, leading the way to resolve chemical shifts and $J$ couplings at the nanoscale., Comment: Matches published version. 20 pages and 7 figures. Comments very welcome

Query-focused summarization (QFS) aims to provide a summary of a document that satisfies information need of a given query and is useful in various IR applications, such as abstractive snippet generation. Current QFS approaches typically involve injecting additional information, e.g. query-answer relevance or fine-grained token-level interaction between a query and document, into a finetuned large language model. However, these approaches often require extra parameters \& training, and generalize poorly to new dataset distributions. To mitigate this, we propose leveraging a recently developed constrained generation model Neurological Decoding (NLD) as an alternative to current QFS regimes which rely on additional sub-architectures and training. We first construct lexical constraints by identifying important tokens from the document using a lightweight gradient attribution model, then subsequently force the generated summary to satisfy these constraints by directly manipulating the final vocabulary likelihood. This lightweight approach requires no additional parameters or finetuning as it utilizes both an off-the-shelf neural retrieval model to construct the constraints and a standard generative language model to produce the QFS. We demonstrate the efficacy of this approach on two public QFS collections achieving near parity with the state-of-the-art model with substantially reduced complexity., Comment: in proceedings of SIGIR 2023

Large pre-trained language models contain societal biases and carry along these biases to downstream tasks. Current in-processing bias mitigation approaches (like adversarial training) impose debiasing by updating a model's parameters, effectively transferring the model to a new, irreversible debiased state. In this work, we propose a novel approach to develop stand-alone debiasing functionalities separate from the model, which can be integrated into the model on-demand, while keeping the core model untouched. Drawing from the concept of AdapterFusion in multi-task learning, we introduce DAM (Debiasing with Adapter Modules) - a debiasing approach to first encapsulate arbitrary bias mitigation functionalities into separate adapters, and then add them to the model on-demand in order to deliver fairness qualities. We conduct a large set of experiments on three classification tasks with gender, race, and age as protected attributes. Our results show that DAM improves or maintains the effectiveness of bias mitigation, avoids catastrophic forgetting in a multi-attribute scenario, and maintains on-par task performance, while granting parameter-efficiency and easy switching between the original and debiased models., Comment: Post EACL 2023 version

Although tissues are usually studied in isolation, this situation rarely occurs in biology, as cells, tissues, and organs, coexist and interact across scales to determine both shape and function. Here, we take a quantitative approach combining data from recent experiments, mathematical modelling, and Bayesian parameter inference, to describe the self-assembly of multiple epithelial sheets by growth and collision. We use two simple and well-studied continuum models, where cells move either randomly or following population pressure gradients. After suitable calibration, both models prove to be practically identifiable, and can reproduce the main features of single tissue expansions. However, our findings reveal that whenever tissue-tissue interactions become relevant, the random motion assumption can lead to unrealistic behaviour. Under this setting, a model accounting for population pressure from different cell populations is more appropriate and shows a better agreement with experimental measurements. Finally, we discuss how tissue shape and pressure affect multi-tissue collisions. Our work thus provides a systematic approach to quantify and predict complex tissue configurations with applications in the design of tissue composites and more generally in tissue engineering.

Diffusion noise is a major source of spectral line broadening in liquid state nano-scale nuclear magnetic resonance with shallow nitrogen-vacancy centres, whose main consequence is a limited spectral resolution. This limitation arises by virtue of the widely accepted assumption that nuclear spin signal correlations decay exponentially in nano-NMR. However, a more accurate analysis of diffusion shows that correlations survive for a longer time due to a power-law scaling, yielding the possibility for improved resolution and altering our understanding of diffusion at the nano-scale. Nevertheless, such behaviour remains to be demonstrated in experiments. Using three different experimental setups and disparate measurement techniques, we present overwhelming evidence of power-law decay of correlations. These result in sharp-peaked spectral lines, for which diffusion broadening need not be a limitation to resolution., Comment: 21 pages and 13 figures. Matches published version. Comments always welcome!

We present BVRI and unfiltered Clear light curves of 70 stripped-envelope supernovae (SESNe), observed between 2003 and 2020, from the Lick Observatory Supernova Search (LOSS) follow-up program. Our SESN sample consists of 19 spectroscopically normal SNe~Ib, two peculiar SNe Ib, six SN Ibn, 14 normal SNe Ic, one peculiar SN Ic, ten SNe Ic-BL, 15 SNe IIb, one ambiguous SN IIb/Ib/c, and two superluminous SNe. Our follow-up photometry has (on a per-SN basis) a mean coverage of 81 photometric points (median of 58 points) and a mean cadence of 3.6d (median of 1.2d). From our full sample, a subset of 38 SNe have pre-maximum coverage in at least one passband, allowing for the peak brightness of each SN in this subset to be quantitatively determined. We describe our data collection and processing techniques, with emphasis toward our automated photometry pipeline, from which we derive publicly available data products to enable and encourage further study by the community. Using these data products, we derive host-galaxy extinction values through the empirical colour evolution relationship and, for the first time, produce accurate rise-time measurements for a large sample of SESNe in both optical and infrared passbands. By modeling multiband light curves, we find that SNe Ic tend to have lower ejecta masses and lower ejecta velocities than SNe~Ib and IIb, but higher $^{56}$Ni masses., Comment: Accepted by MNRAS

Educational inequities leading to deleterious outcomes and related to discipline continue within racially and ethnically diverse schools for myriad of reasons. Districts and schools require deliberate planning and systems change prioritized by educational administrators to address both interpersonal and structural racism and biases. This article outlines a blueprint that leverages the positive behavioral interventions and supports framework in completion of the following: (1) code of conduct revisions; (2) data analysis; (3) cultural and implicit bias awareness; and (5) culturally responsive hiring, training, and teaching. [This paper was published in "Beyond Behavior" v30 p157-168 2021 (EJ1317212).]

Contrastive learning has been the dominant approach to training dense retrieval models. In this work, we investigate the impact of ranking context - an often overlooked aspect of learning dense retrieval models. In particular, we examine the effect of its constituent parts: jointly scoring a large number of negatives per query, using retrieved (query-specific) instead of random negatives, and a fully list-wise loss. To incorporate these factors into training, we introduce Contextual Document Embedding Reranking (CODER), a highly efficient retrieval framework. When reranking, it incurs only a negligible computational overhead on top of a first-stage method at run time (delay per query in the order of milliseconds), allowing it to be easily combined with any state-of-the-art dual encoder method. After fine-tuning through CODER, which is a lightweight and fast process, models can also be used as stand-alone retrievers. Evaluating CODER in a large set of experiments on the MS~MARCO and TripClick collections, we show that the contextual reranking of precomputed document embeddings leads to a significant improvement in retrieval performance. This improvement becomes even more pronounced when more relevance information per query is available, shown in the TripClick collection, where we establish new state-of-the-art results by a large margin., Comment: EMNLP 2022

Teacher emotional factors influence the classroom environment. The purpose of the study was to examine the association of teacher emotional exhaustion and teacher efficacy with student office discipline referrals (ODRs), in-school suspensions (ISSs), and out-of-school suspensions (OSSs) using multilevel logistic regression models. The sample included 105 teachers and 1,663 students from nine elementary schools in the United States. Higher teacher emotional exhaustion was associated with increased use of ODR and ISS but not OSS. For students with teachers experiencing burnout, the odds of receiving an ISS increased by a factor of 1.74 (d=0.31). Greater teacher efficacy was also associated with lower use of OSS but not ODR or ISS. The results suggest that improving teacher efficacy and reducing teacher emotional exhaustion may support the reduced use of exclusionary discipline practices. [This is the online version of an article published in "School Psychology Review." For the final published version of this article, see EJ1279381.]

Mechanical ventilation is one of the most widely used therapies in the ICU. However, despite broad application from anaesthesia to COVID-related life support, many injurious challenges remain. We frame these as a control problem: ventilators must let air in and out of the patient's lungs according to a prescribed trajectory of airway pressure. Industry-standard controllers, based on the PID method, are neither optimal nor robust. Our data-driven approach learns to control an invasive ventilator by training on a simulator itself trained on data collected from the ventilator. This method outperforms popular reinforcement learning algorithms and even controls the physical ventilator more accurately and robustly than PID. These results underscore how effective data-driven methodologies can be for invasive ventilation and suggest that more general forms of ventilation (e.g., non-invasive, adaptive) may also be amenable., Comment: Machine Learning for Health (ML4H) at NeurIPS 2021 - Extended Abstract. arXiv admin note: substantial text overlap with arXiv:2102.06779