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1. STrengthening the REporting of Genetic Association studies (STREGA) - An extension of the STROBE statement

Author

Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y. (Guang Yong), Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), Birkett, N. (Nick), Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y. (Guang Yong), Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), and Birkett, N. (Nick)

Abstract

Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the STrengthening the Reporting of OBservational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed, but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct or analysis.

Published
2009
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2. STrengthening the REporting of genetic association studies (STREGA)-an extension of the strobe statement

Author

Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y., Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), Birkett, N. (Nick), Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y., Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), and Birkett, N. (Nick)

Abstract

Summary Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic assoc

Published
2009
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3. STrengthening the REporting of genetic association studies (STREGA)- An extension of the STROBE statement

Author

Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y., Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), Birkett, N. (Nick), Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y., Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), and Birkett, N. (Nick)

Abstract

Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the STrengthening the Reporting of OBservational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.

Published
2009
Full Text
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4. Strengthening the reporting of genetic association studies (STREGA): An extension of the STROBE statement

Author

Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y., Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), Birkett, N. (Nick), Little, J. (Julian), Higgins, J.P.T. (Julian), Ioannidis, J.P.A. (John), Moher, D. (David), Gagnon, F. (France), Elm, E. (Erik) von, Khoury, M.J. (Muin Joseph), Cohen, B. (Barbara), Davey-Smith, G. (George), Grimshaw, J. (Jeremy), Scheet, P. (Paul), Gwinn, M. (Marta), Williamson, R.E. (Robin), Zou, G.Y., Hutchings, K. (Kim), Johnson, C.Y. (Candice), Tait, V. (Valerie), Wiens, M. (Miriam), Golding, J. (Jean), Duijn, C.M. (Cornelia) van, McLaughlin, J. (John), Paterson, A.D. (Andrew), Wells, G.A. (George), Fortier, I. (Isabel), Freedman, M. (Matthew), Zecevic, M. (Maja), King, R. (Richard), Infante-Rivard, C. (Claire), Stewart, A.F.R. (Alexandre), and Birkett, N. (Nick)

Abstract

Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modeling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.

Published
2009
Full Text
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5. Hematopoietic stem cell transplantation for multiple sclerosis

Author

Burt, A.D. (Alastair), Cohen, B. (Barbara), Rose, J.M. (John), Petersen, F. (Finn), Oyama, T. (Tsuneo), Stefoski, D. (Dusan), Katsamakis, G. (George), Carrier, L. (Lucie), Kozak, T. (Tomas), Muraro, A. (Antonella), Martin, R. (Roland), Hintzen, R.Q. (Rogier), Slavin, S. (Shimon), Karussis, D. (Dimitrios), Haggiag, S. (Shalom), Voltarelli, J. (Julio), Ellison, D.H. (David), Jovanovic, B. (Borko), Popat, U. (Uday), McGuirk, J. (Joseph), Statkute, L. (Laisvyde), Verda, L. (Larissa), Haas, J. (Judith), Arnold, R. (Rudolf), Burt, A.D. (Alastair), Cohen, B. (Barbara), Rose, J.M. (John), Petersen, F. (Finn), Oyama, T. (Tsuneo), Stefoski, D. (Dusan), Katsamakis, G. (George), Carrier, L. (Lucie), Kozak, T. (Tomas), Muraro, A. (Antonella), Martin, R. (Roland), Hintzen, R.Q. (Rogier), Slavin, S. (Shimon), Karussis, D. (Dimitrios), Haggiag, S. (Shalom), Voltarelli, J. (Julio), Ellison, D.H. (David), Jovanovic, B. (Borko), Popat, U. (Uday), McGuirk, J. (Joseph), Statkute, L. (Laisvyde), Verda, L. (Larissa), Haas, J. (Judith), and Arnold, R. (Rudolf)

Abstract

Hematopoietic stem cell transplantation (HSCT) was proposed as a treatment for multiple sclerosis (MS) in 1995 based on favorable results in animal models including experimental autoimmune encephalomyelitis. These initial or first-generation trials were developed by medical oncology subspecialists, used malignancy-specific myeloablative transplantation regimens, and selected patients with secondary progressive MS with rapid progression of disability. In general, these trials suffered from higher than anticipated toxic reactions including treatment-related and disease-related mortality, continued loss of brain volume as seen on magnetic resonance imaging (MRI), and, at least in some patients, continued progressive disability despite marked attenuation or absence of gadolinium-enhancing lesions on MRI. Learning from these experiences, second-generation transplantation trials for MS are using MS-specific nonmyeloablative transplantation regimens and selecting for active relapses despite the use of interferon treatment in patients with less accumulated disability. While still preliminary, results using second-generation nonmyeloablativ

Published
2005
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