1. A remarkable case of thyrotoxicosis initially caused by graves’ disease followed by a probable TSHoma – a case report
- Author
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Mark Quinn, Waiel Bashari, Diarmuid Smith, Mark Gurnell, and Amar Agha
- Subjects
Graves’ disease ,TSH-secreting pituitary adenoma ,TSHoma ,Thyrotropinoma ,Coexistent primary and secondary hyperthyroidism ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Background Graves’ disease is the commonest cause of thyrotoxicosis whilst thyrotropin (TSH)-producing pituitary adenomas (thyrotropinomas, TSHomas) are very rare and account for just 1–2% of all pituitary adenomas. Coexistence of a TSHoma and Graves’ disease has been very rarely reported. Here, we report a case of a patient whose initial presentation with primary thyrotoxicosis due to Graves’ disease, was subsequently followed by a relapse of thyrotoxicosis due to a probable TSHoma. Case A sixty-eight year old woman was referred to our department with classical features of thyrotoxicosis. Initial biochemistry confirmed hyperthyroxinaemia [free thyroxine (fT4) 20.4 pmol/L (reference range 7.0–16.0)] and a suppressed TSH [
- Published
- 2020
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