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24 results on '"Coenen, M.J.J."'

3. The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis

Author

Roelofs, M.F., Wenink, M.H., Toonen, E.J.M., Coenen, M.J.J., Joosten, L.A.B., Berg, W.B. van den, Riel, P.L.C.M. van, and Radstake, T.R.D.J.

Subjects
Pathogenesis and modulation of inflammation [N4i 1], Chronic inflammation and autoimmunity [UMCN 4.2], Genetic defects of metabolism [UMCN 5.1], Evaluation of complex medical interventions [NCEBP 2], Scanning Probe Microscopy, Perception and Action [DCN 1], Determinants in Health and Disease [EBP 1], lipids (amino acids, peptides, and proteins), Microbial pathogenesis and host defense [UMCN 4.1], Auto-immunity, transplantation and immunotherapy [N4i 4], Infection and autoimmunity [NCMLS 1], Immunity, infection and tissue repair [NCMLS 1]
Abstract

Contains fulltext : 70771.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To investigate functional consequences of the Toll-like receptor 4 (TLR4) variant (Asp299Gly) in rheumatoid arthritis (RA). METHODS: Peripheral blood mononuclear cells from 28 patients with RA carrying or not carrying the TLR4 variant were incubated with lipopolysaccharide (LPS) and heat shock protein B8 (HSPB8). Concentrations of interleukin 6 (IL-6), tumor necrosis factor-alpha(TNF-alpha), and IL-10 were determined along with TLR4 and CD14 expression. RESULTS: TLR4 expression was similar in patients carrying or not carrying the variant. In contrast, both LPS and HSPB8 resulted in significantly lower secretion of IL-6, TNF-alpha, and IL-10 in those who carried the variant, whereas the frequency of CD14+ cells was higher in these individuals. CONCLUSION: TLR4 variant clearly reduces its potency to mediate signaling. Correction for CD14+ cells is necessary in comparable experiments.

Published
2008

4. Tuning the viscosity of halogen free bulk heterojunction inks for inkjet printed organic solar cells

Author

Lamont, C.A., Eggenhuisen, T.M., Coenen, M.J.J., Slaats, T.W.L., Andriessen, R., and Groen, P.

Subjects
Industry Electronics, TS - Technical Sciences, Inkjet printing, Industrial Innovation, Bulk heterojunction, Organic photovoltaics, Mechanics, Materials and Structures, HOL - Holst, Printed electronics, Rheology, Ink formulation
Abstract

For the solution processing of organic photovoltaics on an industrial scale, the exclusion of halogenated solvents is a necessity. However, the limited solubility of most semiconducting polymer/fullerene blends in non-halogenated solvents results in ink formulations with low viscosities which poses limitations to the use of roll-to-roll compatible deposition processes, such as inkjet printing. We propose to add polystyrene as a rheological modifier to increase the viscosity of bulk heterojunction (BHJ) non-halogenated inks. The printing and performance of P3HT/PCBM photoactive layer inks are characterized as a function of polystyrene concentration and three different molecular weights. Addition of 1 wt% polystyrene provided a near two-fold gain in viscosity, with the largest viscosity gains coming from the polymer with the highest molecular weight. However, this coincided with greater viscoelastic behavior, which reduced the jetting performance of the inks. Differences in solvent compatibility of the polystyrene/P3HT/PCBM ternary blend resulted in phase separation upon layer drying, whereby polystyrene segregated to the layer-air interface to form an isolated domain or network like topology. Nevertheless, a 1.7-fold increase in dynamic viscosity was obtained for devices with printed BHJ layers containing polystyrene at the expense of a 20% reduction in OPV performance. The improved viscosity and good printing behavior achieved with small additions of polystyrene demonstrates its potential to overcome the limited viscosity resulting from typical non-halogenated ink formulations for semiconducting polymers. These results offer a step forward to the industrialization of inkjet printing as an effective deposition technique for functional layers of organic electronics.

Published
2015

5. From Chaos to Order: Chain-Length Dependence of the Free Energy of Formation of Meso-tetraalkylporphyrin Self-Assembled Monolayer Polymorphs

Author

Reimers, J.R., Panduwinata, D., Visser, J, Chin, Y., Tang, C.G., Goerigk, L., Ford, M.J., Baker, M., Sum, T.J., Coenen, M.J.J., Hendriksen, B.L.M., Elemans, J.A.A.W., Hush, N.S., Crossley, M.J., Reimers, J.R., Panduwinata, D., Visser, J, Chin, Y., Tang, C.G., Goerigk, L., Ford, M.J., Baker, M., Sum, T.J., Coenen, M.J.J., Hendriksen, B.L.M., Elemans, J.A.A.W., Hush, N.S., and Crossley, M.J.

Abstract

Item does not contain fulltext

Published
2016

6. Large area inkjet printing for organic photovoltaics and organic light emitting diodes using non-halogenated ink formulations

Author

Eggenhuisen, T.M., Coenen, M.J.J., Slaats, M.W.L., and Groen, W.A.

Subjects
TS - Technical Sciences, Deposition technique, Industrial Innovation, Halogenation, Organic electronics, Solution-processing, Device performance, HOL - Holst, Light emitting diodes, Industrial production, Chlorinated solvent, Organic photovoltaics, Mechanics, Materials and Structures, Industry, Ink jet printing, Organic light emitting diodes(OLEDs)
Abstract

The transfer of laboratory scale solution processing of organic electronics to large area roll-to-roll production requires the use of up-scalable deposition techniques. Furthermore, industrial production demands the omission of halogenated and other harmful solvents. Here, the authors discuss large area inkjet printing using industrial printheads for organic light emitting diodes (OLEDs) or organic photovoltaics (OPVs) applying halogen-free ink formulations. For the inkjet printing of the small molecule OLED emissive layer a low viscosity ink was selected (1.5 mPa s) to obtain layers with outstanding thickness homogeneity. Devices with 3.75 cm2 active area showed a uniform light emission similar to a device with a spin-coated emissive layer. Ink selection for the photo-active layer for OPVs was mostly determined by the device performance and the solubility of the polymer:electron acceptor blend. The inkjet printed layer showed a significant coffee stain effect, which was dependent on the printed layer thickness as well as the printed area. The loss of active material became smaller for larger printed areas. Devices with the inkjet printed photo-active layer from the halogen-free ink showed similar performance to a layer spin-coated from chlorinated solvents. This shows the potential of inkjet printing as a development and production tool for a variety of large area organic electronics.

Published
2014

7. Combined scanning probe microscopy studies on self-assembled porphyrin monolayers

Author

Coenen, M.J.J., Speller, S.E., Elemans, J.A.A.W., Hendriksen, B.L.M., and Radboud University Nijmegen

Subjects
Scanning Probe Microscopy, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 112894.pdf (Publisher’s version ) (Open Access) Radboud Universiteit Nijmegen, 13 september 2013 Promotor : Speller, S.E. Co-promotores : Elemans, J.A.A.W., Hendriksen, B.L.M. 209 p.

Published
2013

9. A priori calculations of the free energy of formation from solution of polymorphic self-assembled monolayers

Author

Reimers, J.R., Panduwinata, D., Visser, J, Chin, Y., Tang, C.G., Goerigk, L., Ford, M.J., Sintic, M., Sum, T.J., Coenen, M.J.J., Hendriksen, B.L.M., Elemans, J.A.A.W., Hush, N.S., Crossley, M.J., Reimers, J.R., Panduwinata, D., Visser, J, Chin, Y., Tang, C.G., Goerigk, L., Ford, M.J., Sintic, M., Sum, T.J., Coenen, M.J.J., Hendriksen, B.L.M., Elemans, J.A.A.W., Hush, N.S., and Crossley, M.J.

Abstract

Item does not contain fulltext

Published
2015

10. High efficiency, fully inkjet printed organic solar cells with freedom of design

Author

Eggenhuisen, T.M. (author), Galagan, Y. (author), Biezemans, A.F.K.V. (author), Slaats, T.M.W.L. (author), Voorthuijzen, W.P. (author), Kommeren, S. (author), Shanmugam, S. (author), Teunissen, J.P. (author), Hadipour, A. (author), Verhees, W.J.H. (author), Veenstra, S.C. (author), Coenen, M.J.J. (author), Gilot, J. (author), Andriessen, R. (author), Groen, W.A. (author), Eggenhuisen, T.M. (author), Galagan, Y. (author), Biezemans, A.F.K.V. (author), Slaats, T.M.W.L. (author), Voorthuijzen, W.P. (author), Kommeren, S. (author), Shanmugam, S. (author), Teunissen, J.P. (author), Hadipour, A. (author), Verhees, W.J.H. (author), Veenstra, S.C. (author), Coenen, M.J.J. (author), Gilot, J. (author), Andriessen, R. (author), and Groen, W.A. (author)

Abstract

The organic photovoltaics field is maturing and reaching a technology readiness level where the focus is on developing large scale fabrication methods. In this light, fully inkjet printed organic solar cells were demonstrated. Inkjet printing allows direct patterning of all the layers, including the electrodes, offering full freedom of design without the use of masks or structuring by hardware. The semitransparent front and back electrodes consist of PEDOT:PSS and conductive Ag fingers, avoiding the use of ITO. The inkjet printing of six functional layer demonstrated minimal losses in performance as compared to the lab-scale standard, spin coated devices. All-inkjet printed large area (>1 cm2) organic solar cells with power conversion efficiency of 4.1% deposited from environmentally friendly solvents in an air atmosphere are demonstrated for the first time. Organic solar cells were fabricated using industrial scale (512 nozzles) printheads, compatible with R2R technology. To prove the great advantage of inkjet printing as a digital technology allowing freedom of forms and designs, large area organic solar cells with different artistic shapes were demonstrated. Reported results confirm that inkjet printing has high potential for the processing of OPV, allowing quick changes in design as well as the materials., Aerospace Structures & Materials, Aerospace Engineering

Published
2015
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12. Combined scanning probe microscopy studies on self-assembled porphyrin monolayers

Author

Speller, S.E., Elemans, J.A.A.W., Hendriksen, B.L.M., Coenen, M.J.J., Speller, S.E., Elemans, J.A.A.W., Hendriksen, B.L.M., and Coenen, M.J.J.

Abstract

Radboud Universiteit Nijmegen, 13 september 2013, Promotor : Speller, S.E. Co-promotores : Elemans, J.A.A.W., Hendriksen, B.L.M., Contains fulltext : 112894.pdf (publisher's version ) (Open Access)

Published
2013

13. Polymorphism in porphyrin monolayers: the relation between adsorption configuration and molecular conformation

Author

Coenen, M.J.J., Boer, D. den, Bruele, F.J. van den, Habets, T., Timmers, K.A.A.M., Maas, M. van der, Khoury, T., Panduwinata, D., Crossley, M.J., Reimers, J.R., Enckevort, W.J.P. van, Hendriksen, B.L.M., Elemans, J.A.A.W., Speller, S., Coenen, M.J.J., Boer, D. den, Bruele, F.J. van den, Habets, T., Timmers, K.A.A.M., Maas, M. van der, Khoury, T., Panduwinata, D., Crossley, M.J., Reimers, J.R., Enckevort, W.J.P. van, Hendriksen, B.L.M., Elemans, J.A.A.W., and Speller, S.

Abstract

Item does not contain fulltext

Published
2013

15. Controlled templating of porphyrins by a molecular command layer

Author

den Boer, D., Habets, T., Coenen, M.J.J., van der Maas, M., Peters, T.P.J., Crossley, M.J., Khoury, T., Rowan, A.E., Nolte, R.J.M., Speller, S.E., Elemans, J.A.A.W., den Boer, D., Habets, T., Coenen, M.J.J., van der Maas, M., Peters, T.P.J., Crossley, M.J., Khoury, T., Rowan, A.E., Nolte, R.J.M., Speller, S.E., and Elemans, J.A.A.W.

Abstract

Contains fulltext : 91666.pdf (publisher's version ) (Closed access)

Published
2011

16. Little exchange at the liquid/solid interface: Defect-mediated equilibration of physisorbed porphyrin monolayers

Author

Coenen, M.J.J., Cremers, M., den Boer, D., van den Bruele, F.J., Khoury, T., Sintic, M., Crossley, M.J., Enckevort, Willem van, Hendriksen, B.L.M., Elemans, J.A.A.W., Speller, S.E., Coenen, M.J.J., Cremers, M., den Boer, D., van den Bruele, F.J., Khoury, T., Sintic, M., Crossley, M.J., Enckevort, Willem van, Hendriksen, B.L.M., Elemans, J.A.A.W., and Speller, S.E.

Abstract

Contains fulltext : 92010.pdf (publisher's version ) (Open Access)

Published
2011

17. Mechano-catalysis: Cyclohexane oxidation in a silver nanowire break junction

Author

Boer, D. den, Shklyarevskii, O.I., Coenen, M.J.J., Maas, M. van der, Peters, T.P.J., Elemans, J.A.A.W., Speller, Sylvia, Boer, D. den, Shklyarevskii, O.I., Coenen, M.J.J., Maas, M. van der, Peters, T.P.J., Elemans, J.A.A.W., and Speller, Sylvia

Abstract

Contains fulltext : 92061.pdf (publisher's version ) (Closed access)

Published
2011

18. Axial ligand control over monolayer and bilayer formation of metal-salophens at the liquid-solid interface

Author

Elemans, J.A.A.W., Wezenberg, S.J., Coenen, M.J.J., Escudero-Adan, E.C., Benet-Buchholz, J., Boer, D. den, Speller, S.E., Kleij, A.W., De Feyter, S., Elemans, J.A.A.W., Wezenberg, S.J., Coenen, M.J.J., Escudero-Adan, E.C., Benet-Buchholz, J., Boer, D. den, Speller, S.E., Kleij, A.W., and De Feyter, S.

Abstract

Contains fulltext : 83337.pdf (publisher's version ) (Closed access)

Published
2010

20. Electron Transport through CO Studied by Gold Break-Junctions in Nonpolar Liquids

Author

Boer, D. den, Coenen, M.J.J., Maas, M. van der, Peters, T.P.J., Shklyarevskii, O.I., Elemans, J.A.A.W., Rowan, A.E., Speller, S.E., Boer, D. den, Coenen, M.J.J., Maas, M. van der, Peters, T.P.J., Shklyarevskii, O.I., Elemans, J.A.A.W., Rowan, A.E., and Speller, S.E.

Abstract

Contains fulltext : 75731.pdf (publisher's version ) (Closed access)

Published
2009

21. The Arg16Gly variant of the beta2-adrenergic receptor predisposes to hypoglycemia unawareness in type 1 diabetes mellitus.

Author

Schouwenberg, B.J.J.W., Veldman, B.A.J., Spiering, W., Coenen, M.J.J., Franke, B., Tack, C.J.J., Galan, B.E. de, Smits, P., Schouwenberg, B.J.J.W., Veldman, B.A.J., Spiering, W., Coenen, M.J.J., Franke, B., Tack, C.J.J., Galan, B.E. de, and Smits, P.

Abstract

Contains fulltext : 70835.pdf (publisher's version ) (Closed access), Hypoglycemia unawareness has been linked to desensitization of the beta2-adrenergic receptor. Desensitization of the beta2-adrenergic receptor (ADRB2) is genetically determined by the Arg16Gly variant of this receptor. We tested the hypothesis that hypoglycemia unawareness is more common among patients homozygous for the Gly16 variant. We performed genotyping of the A265G (Arg16Gly) polymorphism in the ADRB2 gene in 85 patients with type 1 diabetes and classified them according to hypoglycemia awareness status. A total of 45 patients (53%) were homozygous for Gly16, 32 patients (38%) were heterozygous and eight patients (9%) were homozygous for Arg16. Hypoglycemia unawareness was 3.4-fold more common among patients homozygous for Gly16 than among patients with other variants of the Arg16Gly polymorphism (P=0.014). We conclude that patients with type 1 diabetes who carry two alleles of the Gly16 variant of ADRB2 are at increased risk of developing hypoglycemia unawareness. Future studies are required to confirm these results in larger, independent populations.

Published
2008

22. STM of chemistry at the solid liquid interface

Author

Nalwa, H.S., Boer, D. den, Coenen, M.J.J., Elemans, J.A.A.W., Speller, Sylvia, Nalwa, H.S., Boer, D. den, Coenen, M.J.J., Elemans, J.A.A.W., and Speller, Sylvia

Abstract

Item does not contain fulltext

Published
2008

23. Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis.

Author

Coenen, M.J.J., Toonen, E.J.M., Scheffer, H., Radstake, T.R.D.J., Barrera, P., Franke, B., Coenen, M.J.J., Toonen, E.J.M., Scheffer, H., Radstake, T.R.D.J., Barrera, P., and Franke, B.

Abstract

Item does not contain fulltext, TNF-blocking strategies are widely used in the treatment of rheumatoid arthritis (RA). Three anti-TNF agents are registered for use in RA: etanercept, infliximab and adalimumab. Although anti-TNF therapy is very effective in controlling disease activity and slowing down radiological damage, prolonged response is only seen in approximately 70% of the patients. The causes for nonresponse in the remaining patients have not yet been elucidated. Pharmacogenetic studies focusing on genes involved in RA etiology (and/or progression) and in the pharmacokinetics of TNF-blocking agents have identified markers associated with anti-TNF treatment outcome. In the future, more exhaustive, less hypothesis-driven search strategies are expected to discover additional markers. Identification of these markers might be viewed as the first step towards tailored TNF-blocking therapy for patients with RA. Nevertheless, replication and large prospective studies will be needed to demonstrate the validity of the identified genetic markers before implementation into daily clinical practice.

Published
2007

24. The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis.

Author

Radstake, T.R.D.J., Franke, B., Wenink, M.H., Nabbe, K.C.A.M., Coenen, M.J.J., Welsing, P.M.J., Bonvini, E., Koenig, S., Berg, W.B. van den, Barrera, P., Riel, P.L.C.M. van, Radstake, T.R.D.J., Franke, B., Wenink, M.H., Nabbe, K.C.A.M., Coenen, M.J.J., Welsing, P.M.J., Bonvini, E., Koenig, S., Berg, W.B. van den, Barrera, P., and Riel, P.L.C.M. van

Abstract

Contains fulltext : 35219.pdf (publisher's version ) (Closed access), OBJECTIVE: Fcgamma receptors (FcgammaRs) recognize immune complexes (ICs) and coordinate the immune response by modulating the functions of dendritic cells (DCs). The purpose of this study was to unravel the role of the inhibitory FcgammaRIIb in rheumatoid arthritis (RA) by studying the effect of the FCGR2B 695T>C polymorphism on susceptibility to RA, severity of the disease, and DC function. METHODS: Genotyping was performed in RA patients (n = 246) and healthy blood donors (n = 269). The patients' demographic data, disease severity, and disease progression were assessed over a followup of 6 years. DCs were cultured for flow cytometry to determine the expression of FcgammaRs. For detection of FcgammaRIIb (CD32B), a unique anti-FcgammaRIIb antibody (2B6-fluorescein isothiocyanate [FITC]) was used. The capacity for antigen uptake by DCs was studied by assessing the uptake of FITC-labeled ICs. Levels of cytokine production by DCs were measured during lipopolysaccharide-mediated cell activation in the presence and absence of ICs. RESULTS: Although no role of the FCGR2B variant in RA susceptibility was demonstrated, this variant was associated with a nearly doubled rate of radiologic joint damage during the first 6 years of RA. Multiple regression analysis showed that FCGR2B was by far the strongest predictor of joint damage identified to date. DCs from patients carrying this variant failed to display the inhibitory phenotype normally observed upon IC-mediated triggering of inflammation and displayed diminished FcgammaRII-mediated antigen uptake compared with wild-type DCs. However, the levels of FcgammaRs were not affected, suggesting that the FCGR2B variant alters the function rather than regulation of proteins. CONCLUSION: This study is the first to show that a single genetic variant, the FCGR2B 695T>C polymorphism, is a critical determinant of disease severity in RA and radically changes DC behavior. Our results underscore the key role of DCs in the progression of R

Published
2006

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