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3. Availability and costs of medicines for the treatment of tuberculosis in Europe

Author

Hasan Hafizi, Khachatryan, Naira, Aroyan, Harut, Kabasakalyan, Eduard, Knappik, Michael, Skrahina, Alena, Klimuk, Dzmitry, Nikolenka, Alena, Muylle, Inge, Milanov, Vladimir, Velkovska, Desislava, Tarinska, Neli, Bachiyska, Elizabeta, Jankovic, Mateja, Pieridou, Despo, Adamide, Tonia, Nicolaou, Nicos, Vasakova, Martina, Sukholytka, Mariia, Kopeckà, Emilia, Folkvardsen, Dorte Bek, Svensson, Erik, Danilovits, Manfred, Kummik, Tiina, Vasankari, Tuula, Fréchet-Jachym, Mathilde, Nahmiash, Audrey, Togonidze, Tamar, Avaliani, Zaza, Kinkladze, Inga, Aspindzelashvili, Rusudan, Bichashvili, Teona, Losaberidze, Gulnazi, Merabishvili, Tsitsino, Kalsdorf, Barbara, Manika, Katerina, Tsiakitzis, Karyofyllis, Bakos, Agnes, Ægisdóttir, Tinna Rán, Michelsen, Guðrún Svanhvít, Karlsdóttir, Kristín, McLaughlin, Anne-Marie, Fitzgibbon, Margaret, Chemtob, Daniel, Codecasa, Luigi R., Ferrarese, Maurizio, Torri, Stefania, Gjocaj, Majlinda, Kuksa, Liga, Davidaviciene, Edita, Wirtz, Gil, Perrin, Monique, Asciak, Analita Pace, Chesov, Dumitri, de Lange, Wiel, Akkerman, Onno, Poposka, Biljana Ilievska, Mack, Ulrich, Jensenius, Mogens, Kvalvik, Lajla, Mengshoel, Anne Torunn, Kruczak, Katarzyna, Duarte, Raquel, Ribeiro, Nadine, Ibraim, Elmira, Kaluzhenina, Anna, Barkanova, Olga, Pesut, Dragica, Solovic, Ivan, Svetina, Petra, Souza-Galvão, Maria-Luiza de, Millet, Joan-Pau, Casas, Xavi, Vives, Montserrat, Bruchfeld, Judith, Dalemo, Paulina, Jonsson, Jerker, Aeschbacher, Katrin, Keller, Peter, Özkara, Seref, Tiberi, Simon, Chen, Christabelle, Terleeva, Yana, Dudnyk, Andrii, Günther, Gunar, Guglielmetti, Lorenzo, Leu, Claude, Lange, Christoph, and van Leth, Frank

Published
2023
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10. Availability of drugs and resistance testing for BPaLM regimen for rifampicin-resistant tuberculosis in Europe

Author

Günther, Gunar, primary, Guglielmetti, Lorenzo, additional, Kherabi, Yousra, additional, Duarte, Raquel, additional, Lange, Christoph, additional, Adamides, Tonia, additional, Akkerman, Onno, additional, Andersen, Aase Bengaard, additional, Bakos, Ágnes, additional, Bjarnason, Agnar, additional, Bruchfeld, Judith, additional, Chesov, Dumitru, additional, Codecasa, Luigi Ruffo, additional, Cirillo, Daniela, additional, Danilovits, Manfred, additional, Davidavičienė, Edita, additional, De Souza Galvão, Maria Luiza, additional, Garnier, Sandrine, additional, Gjocaj, Majlinda, additional, Günther, Gunar, additional, Ibraim, Elmira, additional, Kappnik, Michael, additional, Khachatryan, Naira, additional, Klimuk, Dzmitry, additional, Kuksa, Liga, additional, Jachym, Mathilde Frechet, additional, Josefsdottir, Kamilla, additional, Kaluzhenina, Anna, additional, Mack, Ulrich, additional, Makek, Mateja Jankovic, additional, Manika, Katerina, additional, Mclaughlin, Anne- Marie, additional, Mema, Donika, additional, Mengshoel, Anne Torunn, additional, Muylle, Inge, additional, Nanovic, Zorica, additional, Özkara, Şeref, additional, Perl, Sivan, additional, Pesut, Dragica, additional, Pierdou, Despo, additional, Ryskulov, Galym, additional, Skowroński, Marcin, additional, Solovic, Ivan, additional, Sukholytka, Mariia, additional, Svetina, Petra, additional, Terleeva, Yana, additional, Tiberi, Simon, additional, Togonidze, Tamara, additional, Torri, Stefania, additional, Turaev, Laziz, additional, Usmanova, Ruzilya, additional, Wirtz, Gil, additional, Vasankari, Tuula, additional, and Zhdanova, Elena, additional

Published
2024
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11. Worldwide Effects of Coronavirus Disease Pandemic on Tuberculosis Services, January-April 2020

Author

Migliori, Giovanni Battista, Thong, Pei Min, Akkerman, Onno, Alffenaar, Jan-Willem, Alvarez-Navascues, Fernando, Assao-Neino, Mourtala Mohamed, Bernard, Pascale Valerie, Biala, Joshua Sorba, Blanc, Francois-Xavier, Bogorodskaya, Elena M., Borisov, Sergey, Buonsenso, Danilo, Calnan, Marianne, Castellotti, Paola Francesca, Centis, Rosella, Chakaya, Jeremiah Muhwa, Cho, Jin-Gun, Codecasa, Luigi Ruffo, D'Ambrosio, Lia, Denholm, Justin, Enwerem, Martin, Ferrarese, Maurizio, Galvao, Tatiana, Garcia-Clemente, Maria, Garcia-Garcia, Jose-Maria, Gualano, Gina, Gullon-Blanco, Jose Antonio, Inwentarz, Sandra, Ippolito, Giuseppe, Kunst, Heinke, Maryandyshev, Andrei, Melazzini, Mario, Mello, Fernanda Carvalho de Queiroz, Munoz-Torrico, Marcela, Njungfiyini, Patrick Bung, Palmero, Domingo Juan, Palmieri, Fabrizio, Piccioni, Pavilio, Piubello, Alberto, Rendon, Adrian, Sabria, Josefina, Saporiti, Matteo, Scognamiglio, Paola, Sharma, Samridhi, Silva, Denise Rossato, Souleymane, Mahamadou Bassirou, Spanevello, Antonio, Tabernero, Eva, Tadolini, Marina, Tchangou, Michel Eke, Thornton, Alice Boi Yatta, Tiberi, Simon, Udwadia, Zarir F., Sotgiu, Giovanni, Ong, Catherine Wei Min, and Goletti, Delia

Subjects
Ambulatory care facilities -- Statistics -- Safety and security measures -- International aspects, Tuberculosis -- Statistics -- Care and treatment -- International aspects, COVID-19 -- International aspects -- Influence, Health
Abstract

The coronavirus disease (COVID-19) pandemic has affected clinical management of tuberculosis (TB) and TB-related services (2,2). Reports of the first cohorts of patients with COVID-19 and TB have been recently [...]

Published
2020
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12. Expert views on screening for tuberculosis infection in patients commencing treatment with a biologic agent.

Author

Sultana, Adiba, Battista Migliori, Giovanni, D’Ambrosio, Lia, García-García, José-María, Rossato Silva, Denise, Adrian Rendon, Luis, Codecasa, Luigi R., Blanc, Francois-Xavier, Tiberi, Simon, Ong, Catherine W. M., Heffernan13a, Courtney, Sotgiu, Giovanni, Centis, Rosella, and Dobler, Claudia Caroline

Subjects
LATENT tuberculosis, BIOLOGICAL products, MEDICAL screening, BIOLOGICALS, TUBERCULOSIS patients
Abstract

Objective: Many biologic agents cause some degree of immunosuppression, which can increase the risk of reactivation of tuberculosis infection (TBI). This risk is variable between individual biologics. We aimed to assess current (and recommended) clinical practice of TBI screening and treatment among patients initiating treatment with biologic agents. Methods: An online questionnaire was distributed via email to members of the Global Tuberculosis Network and associated professional organisations to seek insights into the screening for and treatment of TBI in patients treated with biologics. Results: A total of 163 respondents in 27 countries answered at least one question. For all biologics described in the questionnaire, respondents advised increasing screening relative to current practice. Observed and supported TBI screening rates in patients treated with TNF-α inhibitors were high, especially for older TNF-α inhibitors. Most participants supported TBI screening in patients treated with B- or T-cell inhibitors but not in those treated with interleukin inhibitors. Guideline awareness was higher for TNF-α inhibitors than for other biologic classes (79% vs. 34%). Conclusions: Although respondents stated that TBI screening rates are lower than what they consider ideal, there was a tendency to recommend TBI screening in patients treated with biologics not known to be associated with an increased risk of TBI. As a result, there is a potential risk of over-screening and over-treatment of TBI, potentially causing harm, in patients treated with biologics other than TNF-α inhibitors. There is a need to research the risk of TBI associated with biologics and for guidelines to address the spectrum of TBI risk across all types of biologics. [ABSTRACT FROM AUTHOR]

Published
2024
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13. The effect of M. tuberculosis lineage on clinical phenotype

Author

Du, Duc Hong, primary, Geskus, Ronald B., additional, Zhao, Yanlin, additional, Codecasa, Luigi Ruffo, additional, Cirillo, Daniela Maria, additional, van Crevel, Reinout, additional, Pascapurnama, Dyshelly Nurkartika, additional, Chaidir, Lidya, additional, Niemann, Stefan, additional, Diel, Roland, additional, Omar, Shaheed Vally, additional, Grandjean, Louis, additional, Rokadiya, Sakib, additional, Ortitz, Arturo Torres, additional, Lân, Nguyễn Hữu, additional, Hà, Đặng Thị Minh, additional, Smith, E. Grace, additional, Robinson, Esther, additional, Dedicoat, Martin, additional, Nhat, Le Thanh Hoang, additional, Thwaites, Guy E., additional, Van, Le Hong, additional, Thuong, Nguyen Thuy Thuong, additional, and Walker, Timothy M., additional

Published
2023
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14. Availability and costs of medicines for the treatment of tuberculosis in Europe

Author

Günther, Gunar, Guglielmetti, Lorenzo, Leu, Claude, Lange, Christoph, van Leth, Frank, Hafizi, Hasan, Khachatryan, Naira, Aroyan, Harut, Kabasakalyan, Eduard, Knappik, Michael, Skrahina, Alena, Klimuk, Dzmitry, Nikolenka, Alena, Muylle, Inge, Milanov, Vladimir, Velkovska, Desislava, Tarinska, Neli, Bachiyska, Elizabeta, Jankovic, Mateja, Pieridou, Despo, Adamide, Tonia, Nicolaou, Nicos, Vasakova, Martina, Sukholytka, Mariia, Kopeckà, Emilia, Andersen, Åse Bengård, Folkvardsen, Dorte Bek, Svensson, Erik, Danilovits, Manfred, Kummik, Tiina, Vasankari, Tuula, Fréchet-Jachym, Mathilde, Nahmiash, Audrey, Togonidze, Tamar, Avaliani, Zaza, Kinkladze, Inga, Aspindzelashvili, Rusudan, Bichashvili, Teona, Losaberidze, Gulnazi, Merabishvili, Tsitsino, Kalsdorf, Barbara, Manika, Katerina, Tsiakitzis, Karyofyllis, Bakos, Agnes, Ægisdóttir, Tinna Rán, Michelsen, Guðrún Svanhvít, Karlsdóttir, Kristín, McLaughlin, Anne-Marie, Fitzgibbon, Margaret, Chemtob, Daniel, Codecasa, Luigi R., Ferrarese, Maurizio, Torri, Stefania, Gjocaj, Majlinda, Kuksa, Liga, Davidaviciene, Edita, Wirtz, Gil, Perrin, Monique, Asciak, Analita Pace, Chesov, Dumitri, de Lange, Wiel, Akkerman, Onno, Poposka, Biljana Ilievska, Mack, Ulrich, Jensenius, Mogens, Kvalvik, Lajla, Mengshoel, Anne Torunn, Kruczak, Katarzyna, Duarte, Raquel, Ribeiro, Nadine, Ibraim, Elmira, Kaluzhenina, Anna, Barkanova, Olga, Pesut, Dragica, Solovic, Ivan, Svetina, Petra, Souza-Galvão, Maria-Luiza de, Millet, Joan-Pau, Casas, Xavi, Vives, Montserrat, Bruchfeld, Judith, Dalemo, Paulina, Jonsson, Jerker, Aeschbacher, Katrin, Keller, Peter, Özkara, Seref, Tiberi, Simon, Chen, Christabelle, Terleeva, Yana, Dudnyk, Andrii, Health Economics and Health Technology Assessment, APH - Global Health, APH - Methodology, and Microbes in Health and Disease (MHD)

Subjects
Microbiology (medical), Evropa, Extensively Drug-Resistant Tuberculosis, Antitubercular Agents, Capacity building, 610 Medicine & health, MDR-TB, Mycobacterium tuberculosis - terapija z zdravili, Microbial Sensitivity Tests, Antimicrobial resistance, Medicines, Mycobacterium tuberculosis - drug therapy, SDG 3 - Good Health and Well-being, Tuberculosis, Multidrug-Resistant, Humans, Tuberculosis, tuberkuloza - terapija z zdravili, health care costs - drug therapy, Mycobacterium tuberculosis, General Medicine, END-TB strategy, udc:616-002, tuberculosis - drug therapy, Costs, stroški zdravstvene oskrbe - terapija z zdravili, Europe, Infectious Diseases, Availability of medicines
Abstract

Objectives: To evaluate the access to comprehensive diagnostics and novel antituberculosis medicines in European countries.Methods: We investigated the access to genotypic and phenotypic Mycobacterium tuberculosis drug susceptibility testing and the availability of antituberculosis drugs and calculated the cost of drugs and treatment regimens at major tuberculosis treatment centres in countries of the WHO European region where rates of drug-resistant tuberculosis are the highest among all WHO regions. Results were stratified by middle-income and high-income countries.Results: Overall, 43 treatment centres from 43 countries participated in the study. For WHO group A drugs, the frequency of countries with the availability of phenotypic drug susceptibility testing was as follows: (a) 75% (30/40) for levofloxacin, (b) 82% (33/40) for moxifloxacin, (c) 48% (19/40) for bedaquiline, and (d) 72% (29/40) for linezolid. Overall, of the 43 countries, 36 (84%) and 24 (56%) countries had access to bedaquiline and delamanid, respectively, whereas only 6 (14%) countries had access to rifapentine. The treatment of patients with extensively drug-resistant tuberculosis with a regimen including a carbapenem was available only in 17 (40%) of the 43 countries. The median cost of regimens for drug-susceptible tuberculosis, multidrug-resistant/rifampicin-resistant tuberculosis (shorter regimen, including bedaquiline for 6 months), and extensively drug-resistant tuberculosis (including bedaquiline, delamanid, and a carbapenem) were €44 (minimum–maximum, €15–152), €764 (minimum–maximum, €542–15152), and €8709 (minimum–maximum, €7965–11759) in middle-income countries (n = 12) and €280 (minimum–maximum, €78–1084), €29765 (minimum–maximum, €11116–40584), and €217591 (minimum–maximum, €82827–320146) in high-income countries (n = 29), respectively.Discussion: In countries of the WHO European region, there is a widespread lack of drug susceptibility testing capacity to new and repurposed antituberculosis drugs, lack of access to essential medications in several countries, and a high cost for the treatment of drug-resistant tuberculosis.

Published
2023
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17. How We Treat Drug-Susceptible Pulmonary Tuberculosis: A Practical Guide for Clinicians.

Author

Riccardi, Niccolò, Occhineri, Sara, Vanino, Elisa, Antonello, Roberta Maria, Pontarelli, Agostina, Saluzzo, Francesca, Masini, Tiziana, Besozzi, Giorgio, Tadolini, Marina, and Codecasa, Luigi

Subjects
TUBERCULOSIS, MEDICAL personnel, INFECTIOUS disease transmission, MEDICAL centers, MYCOBACTERIUM
Abstract

Tuberculosis (TB) remains one of the leading causes of morbidity and mortality worldwide and pulmonary TB (PTB) is the main variant responsible for fueling transmission of the infection. Effective treatment of drug-susceptible (DS) TB is crucial to avoid the emergence of Mycobacterium tuberculosis-resistant strains. In this narrative review, through a fictional suggestive case of DS PTB, we guide the reader in a step-by-step commentary to provide an updated review of current evidence in the management of TB, from diagnosis to post-treatment follow-up. World Health Organization and Centre for Diseases Control (CDC) guidelines for TB, as well as the updated literature, were used to support this manuscript. [ABSTRACT FROM AUTHOR]

Published
2023
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18. The effect of M. tuberculosis lineage on clinical phenotype: a retrospective observational study

Author

Walker, Timothy, primary, Du, Duc Hong, additional, Geskus, Ronald B, additional, Zhao, Yanlin, additional, Codecasa, Luigi Ruffo, additional, Cirillo, Daniela Maria, additional, van Crevel, Reinout, additional, Pascapurnama, Dyshelly Nurkartika, additional, Chaidir, Lidya, additional, Niemann, Stefan, additional, Diel, Roland, additional, Omar, Shaheed Vally, additional, Grandjean, Louis, additional, Rokadiya, Sakib, additional, Ortitz, Arturo Torres, additional, Lân, Nguyễn Hữu, additional, Hà, Đặng Thị Minh, additional, Smith, E. Grace, additional, Robinson, Esther, additional, Dedicoat, Martin, additional, Nhat, Le Thanh Hoang, additional, Thwaites, Guy E, additional, Van, Le Hong, additional, and Thuong, Nguyen Thuy Thuong, additional

Published
2023
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20. COVID-19 Hampered Diagnosis of TB Infection in France, Italy, Spain and the United Kingdom

Author

García-García, José-María, primary, Blanc, François-Xavier, additional, Buonsenso, Danilo, additional, Centis, Rosella, additional, Codecasa, Luigi Ruffo, additional, D’Ambrosio, Lia, additional, Goletti, Delia, additional, Gualano, Gina, additional, Kunst, Heinke, additional, Pontali, Emanuele, additional, Tadolini, Marina, additional, Tiberi, Simon, additional, Ong, Catherine W.M., additional, Sotgiu, Giovanni, additional, and Migliori, Giovanni Battista, additional

Published
2022
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24. The Italian registry of pulmonary non-tuberculous mycobacteria - IRENE: the study protocol

Author

Aliberti, Stefano, Codecasa, Luigi Ruffo, Gori, Andrea, Sotgiu, Giovanni, Spotti, Maura, Di Biagio, Antonio, Calcagno, Andrea, Nardini, Stefano, Assael, Baroukh Maurice, Tortoli, Enrico, Besozzi, Giorgio, Ferrarese, Maurizio, Matteelli, Alberto, Girardi, Enrico, De Lorenzo, Saverio, Seia, Manuela, Gramegna, Andrea, Del Prato, Bruno, Terranova, Leonardo, Oriano, Martina, Sverzellati, Nicola, Mirsaeidi, Mehdi, Chalmers, James D., Haworth, Charles S., Loebinger, Michael R., Aksamit, Timothy, Winthrop, Kevin, Ringshausen, Felix C., Previdi, Giuliana, Blasi, Francesco, and on behalf of the IRENE Network

Published
2018
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27. Advantages and Challenges of Tailored Regimens for Drug-Resistant Tuberculosis: A StopTB Italia Look into the Future

Author

Riccardi, Niccolò, Villa, Simone, Alagna, Riccardo, Giacomelli, Andrea, Saderi, Laura, Cirillo, Daniela Maria, Besozzi, Giorgio, Sotgiu, Giovanni, and Codecasa, Luigi

Subjects
drug-resistance, tuberculosis, treatment, tailored, StopTB, Review
Abstract

The emerge of drug-resistant tuberculosis (TB) strain in recent decades is hampering the efforts of the international community to eliminate the disease worldwide. The World Health Organization (WHO) has drafted many strategies to achieve this ambitious goal. In the very beginning, the aim was to standardize inadequate regimens used in many countries and, thereafter, evolved to tackle the social determinants which hinder TB elimination. However, following the path of narrowing the clinical vision to deal with TB, there is an increased need to personalize the treatment considering both patients and pathogen unique characteristics. In our narrative review, we report the advantages and the backwards in developing a method to implement the concept of precision medicine to the treatment of TB. In this dissertation, we highlight the importance to address different aspects of the diseases encompassing the host and pathogen features, as well as the needs to further implement an adequate follow-up based on the available resources. Nevertheless, many things may hamper the vision of precision medicine in TB, such as the complexity and the costs to develop novel compounds and the costs related to global-scale implementation of patient-centered follow-up. To achieve the ambitious goal of TB elimination, a radical change in TB treatment is needed in order to give a more comprehensive approach based both on patients’ peculiarities and driven by drug susceptibility tests and whole-genome sequencing.

Published
2020

28. Screening for Tuberculosis in Migrants: A Survey by the Global Tuberculosis Network

Author

D’Ambrosio, Lia, primary, Centis, Rosella, additional, Dobler, Claudia C., additional, Tiberi, Simon, additional, Matteelli, Alberto, additional, Denholm, Justin, additional, Zenner, Dominik, additional, Al-Abri, Seif, additional, Alyaquobi, Fatma, additional, Arbex, Marcos Abdo, additional, Belilovskiy, Evgeny, additional, Blanc, François-Xavier, additional, Borisov, Sergey, additional, Carvalho, Anna Cristina C., additional, Chakaya, Jeremiah Muhwa, additional, Cocco, Nicola, additional, Codecasa, Luigi Ruffo, additional, Dalcolmo, Margareth Pretti, additional, Dheda, Keertan, additional, Dinh-Xuan, Anh Tuan, additional, Esposito, Susanna R., additional, García-García, José-María, additional, Li, Yang, additional, Manga, Selene, additional, Marchese, Valentina, additional, Muñoz Torrico, Marcela, additional, Pontali, Emanuele, additional, Rendon, Adrián, additional, Rossato Silva, Denise, additional, Singla, Rupak, additional, Solovic, Ivan, additional, Sotgiu, Giovanni, additional, van den Boom, Martin, additional, Nhung, Nguyen Viet, additional, Zellweger, Jean-Pierre, additional, and Migliori, Giovanni Battista, additional

Published
2021
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29. Risk Assessment of Tuberculosis in Contacts by IFN-γ Release Assays: A Tuberculosis Network European Trials Group Study

Author

Zellweger, Jean-Pierre, Sotgiu, Giovanni, Block, Michael, Dore, Simone, Altet, Neus, Blunschi, Rebecca, Bogyi, Matthias, Bothamley, Graham, Bothe, Christina, Codecasa, Luigi, Costa, Patrizia, Dominguez, Jose, Duarte, Raquel, Fløe, Andreas, Fresard, Isabelle, García-García, José-María, Goletti, Delia, Halm, Petra, Hellwig, Doris, Henninger, Eveline, Heykes-Uden, Helga, Horn, Liane, Kruczak, Katarzyna, Latorre, Irene, Pache, Geneviève, Rath, Heidrun, Ringshausen, Felix C., Ruiz, Asunción Seminario, Solovic, Ivan, de Souza-Galvão, Maria-Luiza, Widmer, Ursula, Witte, Peter, and Lange, Christoph

Published
2015
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30. How to improve TB outpatient service during the SARS-CoV-2 pandemic: an example from a TB low-endemic country

Author

Riccardi, Niccolò, Rodari, Paola, Duranti, Silvia, Villa, Simone, Assante, Luca Rosario, Castellotti, Paola, Ferrarese, Maurizio, Martini, Mariano, Zuppini, Teresa, Tessari, Roberto, Calza, Cristina, Codecasa, Luigi, Besozzi, Giorgio, and Angheben, Andrea

Abstract

Despite notable progresses in the recent decades, tuberculosis (TB) continues to remain a public health concern even in Europe. TB prevention and care should be people-centred, improving ambulatory models across countries, in order to expand access to diagnosis and treatment for both TB infection and disease. Even more, during emergencies such as the current pandemic, when seeking of TB care has been replaced by the fear of coronavirus disease 2019 (COVID-19), TB patients care is fundamental. In this short communication, we document how was possible to implement a TB outpatient service meanwhile a local outbreak of SARS-CoV-2 transmission was ongoing., Journal of Preventive Medicine and Hygiene, Vol. 62 No. 1s3 (2021): SARS-CoV-2 (Covid-19) in the history of the pandemics: a tsunami that is changing the world

Published
2021
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32. Rapid Detection and Quantification of Mycobacterium tuberculosis DNA in Paraffinized Samples by Droplet Digital PCR: A Preliminary Study

Author

Antonello, Maria, primary, Scutari, Rossana, additional, Lauricella, Calogero, additional, Renica, Silvia, additional, Motta, Valentina, additional, Torri, Stefania, additional, Russo, Cristina, additional, Gentile, Leonarda, additional, Cento, Valeria, additional, Colagrossi, Luna, additional, Mattana, Giordana, additional, Codecasa, Luigi Ruffo, additional, Vismara, Chiara, additional, Scaglione, Francesco, additional, Veronese, Silvio Marco, additional, Bonoldi, Emanuela, additional, Bandera, Alessandra, additional, Gori, Andrea, additional, Mazzola, Ester, additional, Perno, Carlo Federico, additional, and Alteri, Claudia, additional

Published
2021
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33. Preliminary observations on IGRA testing for TB infection in patients with severe COVID-19 eligible for immunosuppressive therapy

Author

Bandera, Alessandra, Blasi, Francesco, Campisi, Daniela, Ferrarese, Maurizio, Gramegna, Andrea, Lombardi, Alessandra, Mancon, Alessandro, Mantero, Marco, Muscatello, Antonio, Passerini, Matteo, Piscaglia, Marco, Saporiti, Matteo, Schiuma, Marco, Torre, Alessandro, Aliberti, Stefano, Castellotti, Paola Francesca, Cirillo, Daniela Maria, Grisolia, Antonella, Mangioni, Davide, Marchetti, Giulia, Rossotti, Roberto, Santus, Pierachille, Besozzi, Giorgio, Villa, Simone, and Codecasa, Luigi Ruffo

Published
2020
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37. Amikacin Liposome Inhalation Suspension for Mycobacterium avium Complex Lung Disease: A 12-Month Open-Label Extension Clinical Trial

Author

Winthrop, Kevin L., primary, Flume, Patrick A., additional, Thomson, Rachel, additional, Mange, Kevin C., additional, Yuen, Dayton W., additional, Ciesielska, Monika, additional, Morimoto, Kozo, additional, Ruoss, Stephen J., additional, Codecasa, Luigi R., additional, Yim, Jae-Joon, additional, Marras, Theodore K., additional, van Ingen, Jakko, additional, Wallace, Richard J., additional, Brown-Elliott, Barbara A., additional, Coulter, Chris, additional, and Griffith, David E., additional

Published
2021
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38. Outbreak of pre- and extensively drug-resistant tuberculosis in northern Italy: urgency of cross-border, multidimensional, surveillance systems

Author

Villa, Simone, primary, Tagliani, Elisa, additional, Borroni, Emanuele, additional, Castellotti, Paola Francesca, additional, Ferrarese, Maurizio, additional, Ghodousi, Arash, additional, Lamberti, Anna, additional, Senatore, Sabrina, additional, Faccini, Marino, additional, Cirillo, Daniela Maria, additional, and Codecasa, Luigi Ruffo, additional

Published
2021
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39. The evolution of an ancient disease: tuberculosis discoveries in the centuries

Author

Riccardi, Niccolò, Canetti, Diana, Martini, Mariano, Moussa Diaw, Mama, Di Biagio, Antonio, Codecasa, Luigi, Barberis, Ilaria, and Besozzi, Giorgio

Subjects
0303 health sciences, 03 medical and health sciences, 030306 microbiology, humanities
Abstract

Tuberculosis (TB) and humans have coexisted for more than 40,000 years. The word "tuberculosis" derives from "tubercle", the histological lesion which appears in the organs, described by Pott in the late Eighteenth century and found, by molecular biology, in human skeletons dating back to 5000 BC. Early description of TB can be found in the writings of ancient India and China and in the Bible. In ancient Greece tuberculosis was not considered contagious, but Aristotle recognized the contagious nature of the pig's and ox's scrofula. The suspicion that phthisis is a contagious disease and that isolation can reduce the risk of transmission was expressed for the first time by the Arabian Avicenna, in his work “The canon of medicine”. In 1699, the Health Council of the Republic of Lucca founded the "sanatorium" concept as place of care and isolation. In 1865 Villemain inoculated tubercular material from a human lymph node into a rabbit, obtaining for the first time the typical tubercular lesions. Some years later, on March 24, 1882, Robert Koch announced to the Berlin Society of Physiology the discovery of Mycobacterium tuberculosis. In the same period Virchow improved awareness of risk factors and correct behaviours among the general population. In 1952 Waksman won the Nobel Prize for the discovery of the first active drug against TB: streptomycin. Nevertheless, drug resistance appeared rapidly some years later and it is still a great challenge in TB fight nowadays., Journal of Preventive Medicine and Hygiene, Vol. 61 No. 1s1 (2020): Tuberculosis. The Never Ending Story: past, present and Future Challeng (Parte I)

Published
2020
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40. Outcome of treatment of MDR-TB or drug-resistant patients treated with bedaquiline and delamanid: Results from a large global cohort

Author

Koirala, S., Borisov, Sergey, Danila, Edvardas, Mariandyshev, A., Shrestha, B., Lukhele, N., Dalcolmo, Margareth Pretti, Shakya, S.R., Miliauskas, S., Kuksa, Liga, Manga, Selene, Aleksa, Alena, Denholm, Justin, Khadka, H.B., Skrahina, Alena, Diktanas, S., Ferrarese, Maurizio, Bruchfeld, Judith, Koleva, A., Piubello, Alberto, Koirala, G.S., Udwadia, Zarir Farokh, Palmero, Domingo Juan, Muñoz Torrico, Marcela, GC, R., Gualano, Gina, Grecu, V.I., Motta, I., Papavasileiou, A., Li, Yang, Hoefsloot, Wouter, Kunst, Heinke, Mazza Stalder, J., Payen, Marie Christine, Akkerman, Onno, Bernal, Enrique, Manfrin, Vinicio, Matteelli, Alberto, Mustafa Hamdan, Hamdan, Nieto Marcos, Magnolia, Cadiñanos Loidi, Julen, Cebrian Gallardo, Jose Joaquín, Duarte, Raquel, Escobar Salinas, N., Gomez Rosso, Roscio Gomez, Laniado Laborín, Rafael, Martínez Robles, Elena, Quirós Fernandez, S., Rendón, Adrián, Solovic, Ivan, Tadolini, Marina, Viggiani, Pietro, Belilovski, Evgeny, Boeree, Martin J., Cai, Qingshan, Davidavičienė, Edita, Forsman, L.D., De Los Rios Jefe, Jorge, Drakšienė, J., Duga, A., Elamin, S.E., Filippov, Alexey, Garcia, A., Gaudiesiute, I., Gavazova, B., Gayoso, Regina, Gruslys, V., Jonsson, Jerker, Khimova, E., Madonsela, G., Magis Escurra, C., Marchese, Valentina, Matei, M., Moschos, C., Nakčerienė, B., Nicod, L., Palmieri, Fabrizio, Pontarelli, Agostina, Šmite, Agnese, Souleymane, Mahamadou Bassirou, Vescovo, Marisa, Zablockis, R., Zhurkin, Dmitry, Alffenaar, Jan Willem, Caminero, Jose A., Codecasa, Luigi Ruffo, García García, José María, Esposito, Susanna R., Saderi, L., Spanevello, Antonio, Visca, Dina, Tiberi, Simon, Pontali, Emanuele, Centis, Rosella, D'Ambrosio, L., van den Boom, Martin, Sotgiu, Giovanni, Migliori, Giovanni Battista, Koirala, S., Borisov, Sergey, Danila, Edvardas, Mariandyshev, A., Shrestha, B., Lukhele, N., Dalcolmo, Margareth Pretti, Shakya, S.R., Miliauskas, S., Kuksa, Liga, Manga, Selene, Aleksa, Alena, Denholm, Justin, Khadka, H.B., Skrahina, Alena, Diktanas, S., Ferrarese, Maurizio, Bruchfeld, Judith, Koleva, A., Piubello, Alberto, Koirala, G.S., Udwadia, Zarir Farokh, Palmero, Domingo Juan, Muñoz Torrico, Marcela, GC, R., Gualano, Gina, Grecu, V.I., Motta, I., Papavasileiou, A., Li, Yang, Hoefsloot, Wouter, Kunst, Heinke, Mazza Stalder, J., Payen, Marie Christine, Akkerman, Onno, Bernal, Enrique, Manfrin, Vinicio, Matteelli, Alberto, Mustafa Hamdan, Hamdan, Nieto Marcos, Magnolia, Cadiñanos Loidi, Julen, Cebrian Gallardo, Jose Joaquín, Duarte, Raquel, Escobar Salinas, N., Gomez Rosso, Roscio Gomez, Laniado Laborín, Rafael, Martínez Robles, Elena, Quirós Fernandez, S., Rendón, Adrián, Solovic, Ivan, Tadolini, Marina, Viggiani, Pietro, Belilovski, Evgeny, Boeree, Martin J., Cai, Qingshan, Davidavičienė, Edita, Forsman, L.D., De Los Rios Jefe, Jorge, Drakšienė, J., Duga, A., Elamin, S.E., Filippov, Alexey, Garcia, A., Gaudiesiute, I., Gavazova, B., Gayoso, Regina, Gruslys, V., Jonsson, Jerker, Khimova, E., Madonsela, G., Magis Escurra, C., Marchese, Valentina, Matei, M., Moschos, C., Nakčerienė, B., Nicod, L., Palmieri, Fabrizio, Pontarelli, Agostina, Šmite, Agnese, Souleymane, Mahamadou Bassirou, Vescovo, Marisa, Zablockis, R., Zhurkin, Dmitry, Alffenaar, Jan Willem, Caminero, Jose A., Codecasa, Luigi Ruffo, García García, José María, Esposito, Susanna R., Saderi, L., Spanevello, Antonio, Visca, Dina, Tiberi, Simon, Pontali, Emanuele, Centis, Rosella, D'Ambrosio, L., van den Boom, Martin, Sotgiu, Giovanni, and Migliori, Giovanni Battista

Published
2021

41. Screening for tuberculosis in migrants: a survey by the global tuberculosis network

Author

D’Ambrosio, Lia, Centis, Rosella, Dobler, Claudia C., Tiberi, Simon, Matteelli, Alberto, Denholm, Justin, Zenner, Dominik, Al-Abri, Seif, Alyaquobi, Fatma, Arbex, Marcos Abdo, Belilovski, Evgeny, Blanc, François Xavier, Borisov, Sergey, Carvalho, Anna Cristina C., Chakaya, Jeremiah Muhwa, Cocco, Nicola, Codecasa, Luigi Ruffo, Dalcolmo, Margareth Pretti, Dheda, Keertan, Dinh Xuan, Anh Tuan, Esposito, Susanna R., García García, José María, Li, Yang, Manga, Selene, Marchese, Valentina, Muñoz Torrico, Marcela, Pontali, Emanuele, Rendón, Adrián, Rossato Silva, Denise, Singla, Rupak, Solovic, Ivan, Sotgiu, Giovanni, Van den Boom, Martin, Nhung, Nguyen Viet, Zellweger, Jean Pierre, Migliori, Giovanni Battista, D’Ambrosio, Lia, Centis, Rosella, Dobler, Claudia C., Tiberi, Simon, Matteelli, Alberto, Denholm, Justin, Zenner, Dominik, Al-Abri, Seif, Alyaquobi, Fatma, Arbex, Marcos Abdo, Belilovski, Evgeny, Blanc, François Xavier, Borisov, Sergey, Carvalho, Anna Cristina C., Chakaya, Jeremiah Muhwa, Cocco, Nicola, Codecasa, Luigi Ruffo, Dalcolmo, Margareth Pretti, Dheda, Keertan, Dinh Xuan, Anh Tuan, Esposito, Susanna R., García García, José María, Li, Yang, Manga, Selene, Marchese, Valentina, Muñoz Torrico, Marcela, Pontali, Emanuele, Rendón, Adrián, Rossato Silva, Denise, Singla, Rupak, Solovic, Ivan, Sotgiu, Giovanni, Van den Boom, Martin, Nhung, Nguyen Viet, Zellweger, Jean Pierre, and Migliori, Giovanni Battista

Abstract

Tuberculosis (TB) does not respect borders, and migration confounds global TB control and elimination. Systematic screening of immigrants from TB high burden settings and—to a lesser degree TB infection (TBI)—is recommended in most countries with a low incidence of TB. The aim of the study was to evaluate the views of a diverse group of international health professionals on TB management among migrants. Participants expressed their level of agreement using a six-point Likert scale with different statements in an online survey available in English, French, Mandarin, Spanish, Portuguese and Russian. The survey consisted of eight sections, covering TB and TBI screening and treatment in migrants. A total of 1055 respondents from 80 countries and territories participated between November 2019 and April 2020. The largest professional groups were pulmonologists (16.8%), other clinicians (30.4%), and nurses (11.8%). Participants generally supported infection control and TB surveillance established practices (administrative interventions, personal protection, etc.), while they disagreed on how to diagnose and manage both TB and TBI, particularly on which TBI regimens to use and when patients should be hospitalised. The results of this first knowledge, attitude and practice study on TB screening and treatment in migrants will inform public health policy and educational resources.

Published
2021

42. Predictors of starting antimicrobial treatment in patients with nontuberculous mycobacterial lung disease in the Italian scenario: A SITA GIOVANI-IRENE promoted web-survey

Author

Lombardi, Andrea, primary, Colaneri, Marta, additional, Sambo, Margherita, additional, Di Matteo, Angela, additional, Sacchi, Paolo, additional, Fabbiani, Massimiliano, additional, Codecasa, Luigi, additional, Aliberti, Stefano, additional, Blasi, Francesco, additional, Bandera, Alessandra, additional, Bruno, Raffaele, additional, and Gori, Andrea, additional

Published
2021
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43. Tuberculosis treatment outcomes in a rural area of Senegal: a decade of experience from 2010 to 2019 by StopTB Italia

Author

Riccardi, Niccolò, primary, Villa, Simone, additional, Giacomelli, Andrea, additional, Diaw, Mama M, additional, Ndiaye, Mamoud, additional, Gning, Lamine, additional, Robbiano, Marta, additional, Alagna, Riccardo, additional, Saderi, Laura, additional, Biagio, Antonio Di, additional, Bassetti, Matteo, additional, Cirillo, Daniela M, additional, Sotgiu, Giovanni, additional, Codecasa, Luigi R, additional, Sarr, Marie, additional, and Besozzi, Giorgio, additional

Published
2021
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44. Mycobacterium lentiflavum infection in immunocompetent patient

Author

Molteni, Chiara, Gazzola, Lidia, Cesari, Miriam, Lombardi, Alessandra, Salerno, Franco, Tortoli, Enrico, Codecasa, Luigi, Penati, Valeria, Franzetti, Fabio, and Gori, Andrea

Subjects
Children -- Health aspects, Mycobacterial infections -- Development and progression, Mycobacterial infections -- Diagnosis
Abstract

Mycobacterium lentiflavum is a recently described nontuberculous mycobacterium that has mainly clinical importance in young children with cervical lymphadenitis and in immunocompromised patients. We describe a case of chronic pulmonary [...]

Published
2005

46. Surveillance of adverse events in the treatment of drug-resistant tuberculosis: A global feasibility study

Author

Akkerman, Onno, Aleksa, Alena, Alffenaar, Jan-Willem, Al-Marzouqi, Nada Hassan, Arias-Guillén, Miguel, Belilovski, Evgeny, Bernal, Enrique, Boeree, Martin J., Borisov, Sergey E., Bruchfeld, Judith, Cadiñanos Loidi, Julen, Cai, Qingshan, Caminero, Jose A., Cebrian Gallardo, Jose Joaquín, Centis, Rosella, Codecasa, Luigi Ruffo, D’Ambrosio, Lia, Dalcolmo, Margareth, Danila, Edvardas, Dara, Masoud, Davidavičienė, Edita, Davies Forsman, Lina, De Los Rios Jefe, Jorge, Denholm, Justin, Duarte, Raquel, Elamin, Seifeldin Eltaeb, Ferrarese, Maurizio, Filippov, Alexey, Ganatra, Shashank, Garcia, Ana, García-García, José-María, Gayoso, Regina, Giraldo Montoya, Angela Maria, Gomez Rosso, Roscio Gomez, Gualano, Gina, Hoefsloot, Wouter, Ilievska-Poposka, Biljana, Jonsson, Jerker, Khimova, Elena, Kuksa, Liga, Kunst, Heinke, Laniado-Laborín, Rafael, Li, Yang, Magis-Escurra, Cecile, Manfrin, Vinicio, Manga, Selene, Marchese, Valentina, Martínez Robles, Elena, Maryandyshev, Andrei, Matteelli, Alberto, Migliori, Giovanni Battista, Mullerpattan, Jai B., Munoz-Torrico, Marcela, Mustafa Hamdan, Hamdan, Nieto Marcos, Magnolia, Noordin, Noorliza Mohamad, Palmero, Domingo Juan, Palmieri, Fabrizio, Payen, Marie-Christine, Piubello, Alberto, Pontali, Emanuele, Pontarelli, Agostina, Quirós, Sarai, Rendon, Adrian, Skrahina, Alena, Šmite, Agnese, Solovic, Ivan, Sotgiu, Giovanni, Souleymane, Mahamadou Bassirou, Spanevello, Antonio, Stošić, Maja, Tadolini, Marina, Tiberi, Simon, Udwadia, Zarir Farokh, van den Boom, Martin, Vescovo, Marisa, Viggiani, Pietro, Visca, Dina, Zhurkin, Dmitry, and Zignol, Matteo

Published
2019
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47. Preliminary observations on IGRA testing for TB infection in patients with severe COVID-19 eligible for immunosuppressive therapy

Author

Torre, Alessandro, primary, Aliberti, Stefano, additional, Castellotti, Paola Francesca, additional, Cirillo, Daniela Maria, additional, Grisolia, Antonella, additional, Mangioni, Davide, additional, Marchetti, Giulia, additional, Rossotti, Roberto, additional, Santus, Pierachille, additional, Besozzi, Giorgio, additional, Villa, Simone, additional, Codecasa, Luigi Ruffo, additional, Bandera, Alessandra, additional, Blasi, Francesco, additional, Campisi, Daniela, additional, Ferrarese, Maurizio, additional, Gramegna, Andrea, additional, Lombardi, Alessandra, additional, Mancon, Alessandro, additional, Mantero, Marco, additional, Muscatello, Antonio, additional, Passerini, Matteo, additional, Piscaglia, Marco, additional, Saporiti, Matteo, additional, and Schiuma, Marco, additional

Published
2020
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48. Management of Drug Toxicity in Mycobacterium avium Complex Pulmonary Disease: An Expert Panel Survey

Author

van Ingen, Jakko, primary, Aliberti, Stefano, additional, Andrejak, Claire, additional, Chalmers, James D, additional, Codecasa, Luigi R, additional, Daley, Charles L, additional, Hasegawa, Naoki, additional, Griffith, David E, additional, Hoefsloot, Wouter, additional, Huitt, Gwen, additional, Jarand, Julie, additional, Jhun, Byung Woo, additional, Loebinger, Michael R, additional, Marras, Theodore K, additional, Morimoto, Kozo, additional, Polverino, Eva, additional, Ringshausen, Felix C, additional, Santin, Miguel, additional, Thomson, Rachel, additional, Wagner, Dirk, additional, Wallace, Richard J, additional, Winthrop, Kevin L, additional, and Yim, Jae-Joon, additional

Published
2020
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49. A First Look at the Italian Registry on Pulmonary Non-Tuberculous Mycobacteria (NTM) -IRENE

Author

Aliberti, Stefano, primary, Spotti, Maura, additional, Sotgiu, Giovanni, additional, Ferrarese, Maurizio, additional, Castellotti, Paola Francesca, additional, Gramegna, Andrea, additional, Tadolini, Marina, additional, Mencarini, Jessica, additional, Gualano, Gina, additional, Cerri, Stefania, additional, Montemurro, Giuliano, additional, Gardini, Giulia, additional, Calcagno, Andrea, additional, Dente, Federico, additional, Trezzi, Michele, additional, Faverio, Paola, additional, Malerba, Mario, additional, Cucchetto, Giulia, additional, Tortoli, Enrico, additional, Mirsaeidi, Mehdi, additional, Previdi, Antonella, additional, Gori, Andrea, additional, Codecasa, Luigi Ruffo, additional, and Blasi, Francesco, additional

Published
2020
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50. On tuberculosis and COVID-19 co-infection

Author

Tadolini, Marina, primary, García-García, José-María, additional, Blanc, François-Xavier, additional, Borisov, Sergey, additional, Goletti, Delia, additional, Motta, Ilaria, additional, Codecasa, Luigi Ruffo, additional, Tiberi, Simon, additional, Sotgiu, Giovanni, additional, and Migliori, Giovanni Battista, additional

Published
2020
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