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2. Flemish network on rare connective tissue diseases (CTD):patient pathways in systemic sclerosis. First steps taken

Author

Piette, Y., Van den Bossche, F., Aerts, J., Aerts, N., Ajeganova, S., Badot, V., Berghen, N., Blockmans, D., Brusselle, G., Caeyers, N., De Decker, M., De Haes, P., De Cock, C., De Keyser, F., De Langhe, E., Delcroix, M., De Nutte, H., De Pauw, M., Depicker, A., De Sutter, A., De Sutter, J., Du Four, T., Frank, C., Goubau, J., Guiot, J., Gutermuth, J., Heeman, L., Houssiau, F., Hennes, I., Lenaerts, J., Lintermans, A., Loeys, B., Luyten, H., Maeyaert, B., Malfait, F., Moeyersoons, A., Mostmans, Y., Nijs, J., Poppe, B., Polfliet, K., Ruttens, D., Sabato, V., Schoeters, E., Slabbynck, H., Stuer, A., Tamirou, F., Thevissen, Kristof, Van Kersschaever, G., Vanneuville, B., Van Offel, J., Vanthuyne, M., Van Wabeke, J., Verbist, C., Vos, I., Westhovens, R., Wuyts, W., Yserbyt, J., Smith, V., Piette, Y., Van den Bossche, F., Aerts, J., Aerts, N., Ajeganova, S., Badot, V., Berghen, N., Blockmans, D., Brusselle, G., Caeyers, N., De Decker, M., De Haes, P., De Cock, C., De Keyser, F., De Langhe, E., Delcroix, M., De Nutte, H., De Pauw, M., Depicker, A., De Sutter, A., De Sutter, J., Du Four, T., Frank, C., Goubau, J., Guiot, J., Gutermuth, J., Heeman, L., Houssiau, F., Hennes, I., Lenaerts, J., Lintermans, A., Loeys, B., Luyten, H., Maeyaert, B., Malfait, F., Moeyersoons, A., Mostmans, Y., Nijs, J., Poppe, B., Polfliet, K., Ruttens, D., Sabato, V., Schoeters, E., Slabbynck, H., Stuer, A., Tamirou, F., Thevissen, Kristof, Van Kersschaever, G., Vanneuville, B., Van Offel, J., Vanthuyne, M., Van Wabeke, J., Verbist, C., Vos, I., Westhovens, R., Wuyts, W., Yserbyt, J., and Smith, V.

Abstract

Despite the low prevalence of each rare disease, the total burden is high. Patients with rare diseases encounter numerous barriers, including delayed diagnosis and limited access to high-quality treatments. In order to tackle these challenges, the European Commission launched the European Reference Networks (ERNs), cross-border networks of healthcare providers and patients representatives. In parallel, the aims and structure of these ERNs were translated at the federal and regional levels, resulting in the creation of the Flemish Network of Rare Diseases. In line with the mission of the ERNs and to ensure equal access to care, we describe as first patient pathways for systemic sclerosis (SSc), as a pilot model for other rare connective and musculoskeletal diseases. Consensus was reached on following key messages: 1. Patients with SSc should have multidisciplinary clinical and investigational evaluations in a tertiary reference expert centre at baseline, and subsequently every three to 5 years. Intermediately, a yearly clinical evaluation should be provided in the reference centre, whilst SSc technical evaluations are permissionably executed in a centre that follows SSc-specific clinical practice guidelines. In between, monitoring can take place in secondary care units, under the condition that qualitative examinations and care including interactive multidisciplinary consultations can be provided. 2. Patients with early diffuse cutaneous SSc, (progressive) interstitial lung disease and/or pulmonary arterial hypertension should undergo regular evaluations in specialised tertiary care reference institutions. 3. Monitoring of patients with progressive interstitial lung disease and/or pulmonary (arterial) hypertension will be done in agreement with experts of ERN LUNG.

Published
2024

3. Flemish network on rare connective tissue diseases (CTD): patient pathways in systemic sclerosis. First steps taken

Author

Piette, Y., primary, Van den Bossche, F., additional, Aerts, J., additional, Aerts, N., additional, Ajeganova, S., additional, Badot, V., additional, Berghen, N., additional, Blockmans, D., additional, Brusselle, G., additional, Caeyers, N., additional, De Decker, M., additional, De Haes, P., additional, De Cock, C., additional, De Keyser, F., additional, De Langhe, E., additional, Delcroix, M., additional, De Nutte, H., additional, De Pauw, M., additional, Depicker, A., additional, De Sutter, A., additional, De Sutter, J., additional, Du Four, T., additional, Frank, C., additional, Goubau, J., additional, Guiot, J., additional, Gutermuth, J., additional, Heeman, L., additional, Houssiau, F., additional, Hennes, I., additional, Lenaerts, J., additional, Lintermans, A., additional, Loeys, B., additional, Luyten, H., additional, Maeyaert, B., additional, Malfait, F., additional, Moeyersoons, A., additional, Mostmans, Y., additional, Nijs, J., additional, Poppe, B., additional, Polfliet, K., additional, Ruttens, D., additional, Sabato, V., additional, Schoeters, E., additional, Slabbynck, H., additional, Stuer, A., additional, Tamirou, F., additional, Thevissen, Kristof, additional, Van Kersschaever, G., additional, Vanneuville, B., additional, Van Offel, J., additional, Vanthuyne, M., additional, Van Wabeke, J., additional, Verbist, C., additional, Vos, I., additional, Westhovens, R., additional, Wuyts, W., additional, Yserbyt, J., additional, and Smith, V., additional

Published
2023
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14. Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0(C)

Author

Yadlapati, R, Kahrilas, PJ, Fox, MR, Bredenoord, AJ, Prakash Gyawali, C, Roman, S, Babaei, A, Mittal, RK, Rommel, N, Savarino, E, Sifrim, D, Smout, A, Vaezi, MF, Zerbib, F, Akiyama, J, Bhatia, S, Bor, S, Carlson, DA, Chen, JW, Cisternas, D, Cock, C, Coss-Adame, E, de Bortoli, N, Defilippi, C, Fass, R, Ghoshal, UC, Gonlachanvit, S, Hani, A, Hebbard, GS, Wook Jung, K, Katz, P, Katzka, DA, Khan, A, Kohn, GP, Lazarescu, A, Lengliner, J, Mittal, SK, Omari, T, Park, MI, Penagini, R, Pohl, D, Richter, JE, Serra, J, Sweis, R, Tack, J, Tatum, RP, Tutuian, R, Vela, MF, Wong, RK, Wu, JC, Xiao, Y, Pandolfino, JE, Yadlapati, R, Kahrilas, PJ, Fox, MR, Bredenoord, AJ, Prakash Gyawali, C, Roman, S, Babaei, A, Mittal, RK, Rommel, N, Savarino, E, Sifrim, D, Smout, A, Vaezi, MF, Zerbib, F, Akiyama, J, Bhatia, S, Bor, S, Carlson, DA, Chen, JW, Cisternas, D, Cock, C, Coss-Adame, E, de Bortoli, N, Defilippi, C, Fass, R, Ghoshal, UC, Gonlachanvit, S, Hani, A, Hebbard, GS, Wook Jung, K, Katz, P, Katzka, DA, Khan, A, Kohn, GP, Lazarescu, A, Lengliner, J, Mittal, SK, Omari, T, Park, MI, Penagini, R, Pohl, D, Richter, JE, Serra, J, Sweis, R, Tack, J, Tatum, RP, Tutuian, R, Vela, MF, Wong, RK, Wu, JC, Xiao, Y, and Pandolfino, JE

Abstract

Chicago Classification v4.0 (CCv4.0) is the updated classification scheme for esophageal motility disorders using metrics from high-resolution manometry (HRM). Fifty-two diverse international experts separated into seven working subgroups utilized formal validated methodologies over two-years to develop CCv4.0. Key updates in CCv.4.0 consist of a more rigorous and expansive HRM protocol that incorporates supine and upright test positions as well as provocative testing, a refined definition of esophagogastric junction (EGJ) outflow obstruction (EGJOO), more stringent diagnostic criteria for ineffective esophageal motility and description of baseline EGJ metrics. Further, the CCv4.0 sought to define motility disorder diagnoses as conclusive and inconclusive based on associated symptoms, and findings on provocative testing as well as supportive testing with barium esophagram with tablet and/or functional lumen imaging probe. These changes attempt to minimize ambiguity in prior iterations of Chicago Classification and provide more standardized and rigorous criteria for patterns of disorders of peristalsis and obstruction at the EGJ.

Published
2021

36. TQM and BPR: lessons for maintenance management

Author

Hipkin, I.B. and De Cock, C.

Subjects
Maintenance -- Management, Engineering firms -- Management, Business, Business, general
Abstract

Competitive pressures on manufacturing organisations have obliged them to look at all improvement possibilities. Among the most popular and well-documented change interventions have been total quality management (TQM) and business process reengineering (BPR). As the management of physical assets now accounts for a rapidly increasing share of operational costs, greater attention is being directed to maintenance thinking. Two maintenance interventions - reliability-centred maintenance (RCM) and total productive maintenance (TPM) - have seen significant industrial application over the last decade. It is the purpose of this paper to apply the general approach of Meredith in an earlier paper to analyse the implementation of these with reference to the TQM, BPR and other change intervention literature and to assess the extent to which the maintenance implementation follows the path of other interventions. Four postulates relating to the implementation of new maintenance systems are analysed: the significance of a prescriptive methodology, quantification of objectives, managerial attitudes, and the importance of not appending maintenance initiatives to existing operations practices. This will facilitate a critical assessment of the potential for and implications of RCM and TPM intervention and thus contribute to the development of the maintenance management field.

Published
2000

39. Effectiveness of conversational agents (virtual assistants) in health care: protocol for a systematic review (Preprint)

Author

De Cock, C, Milne-Ives, M, Van Velthoven, MH, Alturkistani, A, Lam, C, and Meinert, E

Abstract

Background: Conversational agents have evolved in recent decades to become multimodal, multifunctional platforms that have the potential to automate a diverse range of health-related activities, supporting the general public, patients and physicians. Multiple studies have reported the development of these agents and recent systematic reviews have described the scope of use of conversational agents in healthcare. However, there is little focus on the effectiveness of these systems, thus the viability and applicability of these systems is unclear. Objective: The objective of this systematic review is to assess the effectiveness of conversational agents in healthcare and to identify limitations, adverse events and areas for future investigation of these agents. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols will be used to structure this protocol. The focus of the systematic review is guided by a population, intervention, comparator, and outcome framework . A systematic search of PubMed (Medline), EMBASE, CINAHL, and Web of Science will be conducted. Two authors will independently screen the titles and abstracts of identified references and select studies according to the eligibility criteria. Any discrepancies will then be discussed and resolved. Two reviewers will extract and validate data, respectively, from included studies into a standardised form and conduct quality appraisal. Results: At the time of writing, we have begun a preliminary literature search and piloting of the study selection process. Conclusions: This systematic review aims to clarify the effectiveness, limitations and future applications of conversational agents in healthcare. Our findings may be used to inform future development of conversational agents and further the personalisation of care.

Published
2019

40. LETTER TO THE EDITOR

Author

de Cock, C. C., Jessurun, E. R., and Allaart, C. A.

Published
2007

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