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1. Anthracycline-induced cardiotoxicity: A multicenter randomised trial comparing two strategies for guiding prevention with enalapril: The International CardioOncology Society-one trial

Author

Cipolla, C.M., Cardinale, D., Ciceri, F., Latini, R., Sandri, M.T., Maggioni, A.P., Labianca, R., Tettamanti, M., Senni, M., Finzi, A., Grosso, F., Vago, T., Civelli, M., Gramenzi, S., Masson, S., Balconi, G., Bernasconi, R., Salvatici, M., Nicolis, E., Barlera, S., Magnoli, M., Buratti, M.G., Ojeda Fernandez, M.L., Franzosi, M.G., Staszewsky, L., Vasamì, A., Malossi, A., Sicuro, M., Thiebat, B., Barè, C., Corzani, A., Coccolo, F., Colecchia, S., Pellegrini, C., Bregni, M., Appio, L., Caico, I., G.Rossetti, Mesenzani, O., Campana, C., Giordano, M., Gilardoni, M., Scognamiglio, G., Corrado, G., Battagin, D., De Rosa, F., Carpino, C., Palazzo, S., Monopoli, A., Milandri, C., Giannessi, P.G., Zipoli, G., Ghisoni, F., Rizzo, A., Pastori, P., Callegari, S., Sesenna, C., Colombo, A., G.Curigliano, Fodor, C., Mangiavacchi, M., Cavina, R., Guiducci, D., Mazza, R., Turazza, F.M., Vallerio, P., Marbello, L., Sala, E., Fragasso, G., Trinca, S., Aquilina, M., Rocca, A., Farolfi, A., Andreis, D., Gori, S., Barbieri, E., Lanzoni, L., Marchetti, F., Falci, C., Bianchi, A., Mioranza, E., Banzato, A., Re, F., Gaibazzi, N., Gullo, M., Turina, M.C., Gervasi, E., Giaroli, F., Nassiacos, D., Verusio, C., Barco, B., Bertolini, A., Cucchi, G., Menatti, E., Sinagra, G., Aleksova, A., Guglielmi, A., Pinotti, G., Gueli, R., Mongiardi, C., Vallini, I., Cardinale, Daniela, Ciceri, Fabio, Latini, Roberto, Franzosi, Maria Grazia, Sandri, Maria Teresa, Civelli, Maurizio, Cucchi, GianFranco, Menatti, Elisabetta, Mangiavacchi, Maurizio, Cavina, Raffaele, Barbieri, Enrico, Gori, Stefania, Colombo, Alessandro, Curigliano, Giuseppe, Salvatici, Michela, Rizzo, Antonio, Ghisoni, Francesco, Bianchi, Alessandra, Falci, Cristina, Aquilina, Michele, Rocca, Andrea, Monopoli, Anna, Milandri, Carlo, Rossetti, Giuseppe, Bregni, Marco, Sicuro, Marco, Malossi, Alessandra, Nassiacos, Daniele, Verusio, Claudio, Giordano, Monica, Staszewsky, Lidia, Barlera, Simona, Nicolis, Enrico B., Magnoli, Michela, Masson, Serge, and Cipolla, Carlo M.

Published
2018
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5. Anthracycline-induced cardiotoxicity: A multicenter randomised trial comparing two strategies for guiding prevention with enalapril: The International CardioOncology Society-one trial

Author

Cardinale, D, Ciceri, F, Latini, R, Franzosi, M, Sandri, M, Civelli, M, Cucchi, G, Menatti, E, Mangiavacchi, M, Cavina, R, Barbieri, E, Gori, S, Colombo, A, Curigliano, G, Salvatici, M, Rizzo, A, Ghisoni, F, Bianchi, A, Falci, C, Aquilina, M, Rocca, A, Monopoli, A, Milandri, C, Rossetti, G, Bregni, M, Malossi, A, Nassiacos, D, Verusio, C, Giordano, M, Staszewsky, L, Barlera, S, Nicolis, E, Magnoli, M, Masson, S, Cipolla, C, Curigliano, Sicuro, M, Rossetti, Maggioni, A, Labianca, R, Tettamanti, M, Senni, M, Finzi, A, Grosso, F, Vago, T, Gramenzi, S, Balconi, G, Bernasconi, R, Buratti, M, Ojeda-Fernandez, M, Vasami, A, Thiebat, B, Bare, C, Corzani, A, Coccolo, F, Colecchia, S, Pellegrini, C, Appio, L, Caico, I, Mesenzani, O, Campana, C, Gilardoni, M, Scognamiglio, G, Corrado, G, Battagin, D, De Rosa, F, Carpino, C, Palazzo, S, Giannessi, P, Zipoli, G, Pastori, P, Callegari, S, Sesenna, C, Fodor, C, Guiducci, D, Mazza, R, Turazza, F, Vallerio, P, Marbello, L, Sala, E, Fragasso, G, Trinca, S, Farolfi, A, Andreis, D, Lanzoni, L, Marchetti, F, Mioranza, E, Banzato, A, Re, F, Gaibazzi, N, Gullo, M, Turina, M, Gervasi, E, Giaroli, F, Barco, B, Bertolini, A, Sinagra, G, Aleksova, A, Guglielmi, A, Pinotti, G, Gueli, R, Mongiardi, C, Vallini, I, Cardinale D., Ciceri F., Latini R., Franzosi M. G., Sandri M. T., Civelli M., Cucchi G., Menatti E., Mangiavacchi M., Cavina R., Barbieri E., Gori S., Colombo A., Curigliano G., Salvatici M., Rizzo A., Ghisoni F., Bianchi A., Falci C., Aquilina M., Rocca A., Monopoli A., Milandri C., Rossetti G., Bregni M., Malossi A., Nassiacos D., Verusio C., Giordano M., Staszewsky L., Barlera S., Nicolis E. B., Magnoli M., Masson S., Cipolla C. M., Sicuro M., Maggioni A. P., Labianca R., Tettamanti M., Senni M., Finzi A., Grosso F., Vago T., Gramenzi S., Balconi G., Bernasconi R., Nicolis E., Buratti M. G., Ojeda-Fernandez M. L., Vasami A., Thiebat B., Bare C., Corzani A., Coccolo F., Colecchia S., Pellegrini C., Appio L., Caico I., Mesenzani O., Campana C., Gilardoni M., Scognamiglio G., Corrado G., Battagin D., De Rosa F., Carpino C., Palazzo S., Giannessi P. G., Zipoli G., Pastori P., Callegari S., Sesenna C., Fodor C., Guiducci D., Mazza R., Turazza F. M., Vallerio P., Marbello L., Sala E., Fragasso G., Trinca S., Farolfi A., Andreis D., Lanzoni L., Marchetti F., Mioranza E., Banzato A., Re F., Gaibazzi N., Gullo M., Turina M. C., Gervasi E., Giaroli F., Barco B., Bertolini A., Sinagra G., Aleksova A., Guglielmi A., Pinotti G., Gueli R., Mongiardi C., Vallini I., Cardinale, D, Ciceri, F, Latini, R, Franzosi, M, Sandri, M, Civelli, M, Cucchi, G, Menatti, E, Mangiavacchi, M, Cavina, R, Barbieri, E, Gori, S, Colombo, A, Curigliano, G, Salvatici, M, Rizzo, A, Ghisoni, F, Bianchi, A, Falci, C, Aquilina, M, Rocca, A, Monopoli, A, Milandri, C, Rossetti, G, Bregni, M, Malossi, A, Nassiacos, D, Verusio, C, Giordano, M, Staszewsky, L, Barlera, S, Nicolis, E, Magnoli, M, Masson, S, Cipolla, C, Curigliano, Sicuro, M, Rossetti, Maggioni, A, Labianca, R, Tettamanti, M, Senni, M, Finzi, A, Grosso, F, Vago, T, Gramenzi, S, Balconi, G, Bernasconi, R, Buratti, M, Ojeda-Fernandez, M, Vasami, A, Thiebat, B, Bare, C, Corzani, A, Coccolo, F, Colecchia, S, Pellegrini, C, Appio, L, Caico, I, Mesenzani, O, Campana, C, Gilardoni, M, Scognamiglio, G, Corrado, G, Battagin, D, De Rosa, F, Carpino, C, Palazzo, S, Giannessi, P, Zipoli, G, Pastori, P, Callegari, S, Sesenna, C, Fodor, C, Guiducci, D, Mazza, R, Turazza, F, Vallerio, P, Marbello, L, Sala, E, Fragasso, G, Trinca, S, Farolfi, A, Andreis, D, Lanzoni, L, Marchetti, F, Mioranza, E, Banzato, A, Re, F, Gaibazzi, N, Gullo, M, Turina, M, Gervasi, E, Giaroli, F, Barco, B, Bertolini, A, Sinagra, G, Aleksova, A, Guglielmi, A, Pinotti, G, Gueli, R, Mongiardi, C, Vallini, I, Cardinale D., Ciceri F., Latini R., Franzosi M. G., Sandri M. T., Civelli M., Cucchi G., Menatti E., Mangiavacchi M., Cavina R., Barbieri E., Gori S., Colombo A., Curigliano G., Salvatici M., Rizzo A., Ghisoni F., Bianchi A., Falci C., Aquilina M., Rocca A., Monopoli A., Milandri C., Rossetti G., Bregni M., Malossi A., Nassiacos D., Verusio C., Giordano M., Staszewsky L., Barlera S., Nicolis E. B., Magnoli M., Masson S., Cipolla C. M., Sicuro M., Maggioni A. P., Labianca R., Tettamanti M., Senni M., Finzi A., Grosso F., Vago T., Gramenzi S., Balconi G., Bernasconi R., Nicolis E., Buratti M. G., Ojeda-Fernandez M. L., Vasami A., Thiebat B., Bare C., Corzani A., Coccolo F., Colecchia S., Pellegrini C., Appio L., Caico I., Mesenzani O., Campana C., Gilardoni M., Scognamiglio G., Corrado G., Battagin D., De Rosa F., Carpino C., Palazzo S., Giannessi P. G., Zipoli G., Pastori P., Callegari S., Sesenna C., Fodor C., Guiducci D., Mazza R., Turazza F. M., Vallerio P., Marbello L., Sala E., Fragasso G., Trinca S., Farolfi A., Andreis D., Lanzoni L., Marchetti F., Mioranza E., Banzato A., Re F., Gaibazzi N., Gullo M., Turina M. C., Gervasi E., Giaroli F., Barco B., Bertolini A., Sinagra G., Aleksova A., Guglielmi A., Pinotti G., Gueli R., Mongiardi C., and Vallini I.

Abstract

Background: Troponin changes over time have been suggested to allow for an early diagnosis of cardiac injury ensuing cancer chemotherapy; cancer patients with troponin elevation may benefit of therapy with enalapril. It is unknown whether a preventive treatment with enalapril may further increase the benefit. Methods: The International CardioOncology Society-one trial (ICOS-ONE) was a controlled, open-label trial conducted in 21 Italian hospitals. Patients were randomly assigned to two strategies: enalapril in all patients started before chemotherapy (CT; ‘prevention’ arm), and enalapril started only in patients with an increase in troponin during or after CT (‘troponin-triggered’ arm). Troponin was assayed locally in 2596 blood samples, before and after each anthracycline-containing CT cycle and at each study visit; electrocardiogram and echocardiogram were done at baseline, and at 1, 3, 6 and 12-month follow-up. Primary outcome was the incidence of troponin elevation above the threshold. Findings: Of the 273 patients, 88% were women, mean age 51 ± 12 years. The majority (76%) had breast cancer, 3% had a history of hypertension and 4% were diabetic. Epirubicin and doxorubicin were most commonly prescribed, with median cumulative doses of 360 [270–360] and 240 [240–240] mg/m2, respectively. The incidence of troponin elevation was 23% in the prevention and 26% in the troponin-triggered group (p = 0.50). Three patients (1.1%) -two in the prevention, one in the troponin-triggered group-developed cardiotoxicity, defined as 10% point reduction of LV ejection fraction, with values lower than 50%. Interpretation: Low cumulative doses of anthracyclines in adult patients with low cardiovascular risk can raise troponins, without differences between the two strategies of giving enalapril. Considering a benefit of enalapril in the prevention of LV dysfunction, a troponin-triggered strategy may be more convenient.

Published
2018

9. A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM risk-SCD)

Author

O'Mahony C., Jichi F., Pavlou M., Monserrat L., Anastasakis A., Rapezzi C., Biagini E., Gimeno J. R., Limongelli G., McKenna W. J., Omar R. Z., Elliott P. M., Ortiz-Genga M., Fernandez X., Vlagouli V., Stefanadis C., Coccolo F., Sandoval M. J. O., Pacileo G., Masarone D., Pantazis A., Tome-Esteban M., Dickie S., Lambiase P. D., Rahman S., O'Mahony C, Jichi F, Pavlou M, Monserrat L, Anastasakis A, Rapezzi C, Biagini E, Gimeno JR, Limongelli G, McKenna WJ, Omar RZ, Elliott PM, Hypertrophic Cardiomyopathy Outcomes Investigators, O'Mahony, C., Jichi, F., Pavlou, M., Monserrat, L., Anastasakis, A., Rapezzi, C., Biagini, E., Gimeno, J. R., Limongelli, G., Mckenna, W. J., Omar, R. Z., Elliott, P. M., Ortiz-Genga, M., Fernandez, X., Vlagouli, V., Stefanadis, C., Coccolo, F., Sandoval, M. J. O., Pacileo, G., Masarone, D., Pantazis, A., Tome-Esteban, M., Dickie, S., Lambiase, P. D., and Rahman, S.

Subjects
Adult, Male, medicine.medical_specialty, Prognosi, medicine.medical_treatment, Reproducibility of Result, Left ventricular hypertrophy, Ventricular tachycardia, Risk Assessment, sudden cardiac death, Sudden cardiac death, NO, HYPERTROPHIC CARDIOMYOPATHY, IMPLANTABLE CARDIOVERTER DEFIBRILLATOR, Risk prediction model, Retrospective Studie, Internal medicine, medicine, cardiovascular diseases, Proportional hazards model, business.industry, Hypertrophic cardiomyopathy, Retrospective cohort study, Cardiomyopathy, Hypertrophic, Middle Aged, medicine.disease, Implantable cardioverter-defibrillator, Death, Sudden, Cardiac, Sample Size, Cardiology, Proportional Hazards Model, Female, Cardiology and Cardiovascular Medicine, Risk assessment, business, Human
Abstract

Aims: Hypertrophic cardiomyopathy(HCM)is a leading cause of sudden cardiac death (SCD) in young adults. Current risk algorithms provide only a crude estimate of risk and fail to account for the different effect size of individual risk factors. The aim of this study was to develop and validate a new SCD risk prediction model that provides individualized risk estimates. Methods and results: The prognostic model was derived from a retrospective, multi-centre longitudinal cohort study. The model was developed fromthe entire data set using theCox proportional hazards model and internally validated using bootstrapping. The cohort consisted of 3675 consecutive patients from six centres. During a follow-up period of 24 313 patient-years (median 5.7 years), 198 patients (5%) died suddenly or had an appropriate implantable cardioverter defibrillator (ICD) shock. Of eight pre-specified predictors, age, maximal left ventricular wall thickness, left atrial diameter, left ventricular outflow tract gradient, family history of SCD, non-sustained ventricular tachycardia, and unexplained syncope were associated with SCD/appropriate ICD shock at the 15% significance level. These predictors were included in the final model to estimate individual probabilities of SCD at 5 years. The calibration slope was 0.91 (95% CI: 0.74, 1.08), C-index was 0.70 (95% CI: 0.68, 0.72), and D-statistic was 1.07 (95% CI: 0.81, 1.32). For every 16 ICDs implanted in patients with ≥4% 5-year SCD risk, potentially 1 patient will be saved from SCD at 5 years. A second model with the data set split into independent development and validation cohorts had very similar estimates of coefficients and performance when externally validated. Conclusion: This is the first validatedSCDrisk prediction model for patients withHCMand provides accurate individualized estimates for the probability of SCD using readily collected clinical parameters. ©The Author 2013.

Published
2014

10. Consensus document on endomyocardial biopsy of the Associazione per la Patologia Cardiovascolare Italiana

Author

Leone O, Rapezzi C, Sinagra G, Angelini A, Eloisa Arbustini, Bartoloni G, Basso C, Al, Caforio, Calabrese F, Coccolo F, d'Amati G, Mariesi E, Milanesi O, Nodari S, Oliva F, Perkan A, Prandstraller D, Pucci A, Ramondo A, Silvestri F, Valente M, Thiene G, Federazione Italiana di Cardiologia, Associazione per la Patologia Cardiovascolare Italiana, Leone O, Rapezzi C, Sinagra G, Angelini A, Arbustini E, Bartoloni G, Basso C, Caforio AL, Calabrese F, Coccolo F, d'Amati G, Mariesi E, Milanesi O, Nodari S, Oliva F, Perkan A, Prandstraller D, Pucci A, Ramondo A, Silvestri F, Valente M, Thiene G, Leone, O, Rapezzi, C, Sinagra, Gianfranco, Angelini, A, Arbustini, E, Bartoloni, G, Basso, C, Caforio, Al, Calabrese, F, Coccolo, F, D'Amati, G, Mariesi, E, Milanesi, O, Nodari, S, Oliva, F, Perkan, A, Prandstraller, D, Pucci, A, Ramondo, A, Silvestri, F, Valente, M, Thiene, G, Federazione Italiana di, Cardiologia, and Associazione per la Patologia Cardiovascolare, Italiana

Subjects
Heart Neoplasms, Myocarditis, Iron Overload, Mitochondrial Diseases, Clinical Protocols, Heart Diseases, Biopsy, Myocardium, endomyocardial biopsy, Heart Transplantation, Humans, Amyloidosis
Abstract

The Italian Scientific Associations of Cardiologists and Cardiovascular Pathologists have produced this consensus document on the diagnostic role of endomyocardial biopsy (EMB) in terms of techniques, analysis and reporting. The document is intended for clinical cardiologists, hemodynamic experts, electrophysiologists, surgical pathologists, and cardiac surgeons. It has three main aims: a) to collocate EMB in the context of currently available tools for diagnosis of heart diseases; b) to provide recommendations for rational implementation; c) to outline key characteristics (standards) for Italian cardiology and surgical pathology centers that perform and analyze EMB. A general lack of prospective, controlled studies addressing EMB prohibited the use of traditional evidence-based recommendations that rely on classes of available evidence. Thus, it was agreed that three key points should be taken into account: a) the specific pathology to be diagnosed (or excluded); b) the existence of any alternative, non-invasive diagnostic techniques; c) the overall consequences of reaching a definite diagnosis on patients' clinical management. Accordingly, we propose recommendations for EMB based on the following levels of diagnostic value: level 1: no alternative method exists to reach a definite diagnosis that can have obvious consequences for clinical management; level 2a: no alternative method exists to reach a definite diagnosis; however, the implications for clinical management are uncertain; level 2b: no alternative method exists to reach a definite diagnosis; however, the diagnosis would not influence clinical management; level 3: an alternative method exists to reach a definite diagnosis. The second part of the document proposes current protocols for the preparation, analysis and reporting of EMB in the context of each main pathologic entity. Particular attention is given to tissue characterization and implementation of molecular tests.

Published
2009

11. Malattie del miocardio

Author

RAPEZZI, CLAUDIO, Coccolo F., Branzi A, Picchio FM, Rapezzi C, and Coccolo F

Subjects
MIOCARDITE, CLASSIFICAZIONE, CARDIOMIOPATIA, NO
Abstract

cardiomiopatie e miocarditi

Published
2013

12. Differential Effect of Everolimus and Metabolic Risk Factors on Early vs. Late Progression of Allograft Vasculopathy: Dissecting Two Faces of the Same Disease

Author

MASETTI, MARCO, POTENA, LUCIANO, PRESTINENZI, PAOLA, TAGLIERI, NEVIO, SAIA, FRANCESCO, MAGNANI, GAIA, GRIGIONI, FRANCESCO, BRANZI, ANGELO, Nardozza M, Pece V, Coccolo F, Fallani F, Masetti M, Potena L, Nardozza M, Prestinenzi P, Pece V, Taglieri N, Saia F, Magnani G, Coccolo F, Fallani F, Grigioni F, and Branzi A.

Subjects
EVEROLIMUS, Risk Factors, Allograft Vasculopathy
Published
2012

13. Interplay between Pulmonary Hypertension and Donor-Recipient Matching in the Risk for Early Graft Failure after Heart Transplantation

Author

POTENA, LUCIANO, MARTIN SUAREZ, SOFIA, MASETTI, MARCO, MAGNANI, GAIA, RUSSO, ANTONIO, GRIGIONI, FRANCESCO, BRANZI, ANGELO, ARPESELLA, GIORGIO, Manfredini V, Pilato E, Fallani F, Coccolo F, Potena L, Martin-Suarez, Manfredini V, Masetti M, Pilato E, Magnani g, Fallani F, Coccolo F, Russo A, Grigioni F, Branzi A, and Arpesella G.

Subjects
Pulmonary Hypertension, HEART TRANSPLANTATION
Published
2012

14. Differential Effects of Everolimus on Early vs. Late Allograft Vasculopathy Progression in Heart Transplant Recipients: a Longitudinal IVUS-Based Study

Author

POTENA, LUCIANO, MASETTI, MARCO, PRESTINENZI, PAOLA, TAGLIERI, NEVIO, MAGNANI, GAIA, SAIA, FRANCESCO, BARBERINI, FRANCESCO, RUSSO, ANTONIO, GRIGIONI, FRANCESCO, BRANZI, ANGELO, Nardozza M, Romani P, Coccolo F, Fallani F, Potena L, Masetti M, Nardozza M, Prestinenzi P, Taglieri N, Magnani G, Saia F, Romani P, Barberini F, Coccolo F, Fallani F, Russo A, Grigioni F, and Branzi A

Subjects
EVEROLIMUS, HEART TRANSPLANTATION, Late Allograft Vasculopathy
Published
2011

15. DOCUMENTO DI CONSENSO SULLA BIOPSIA ENDOMIOCARDICA PROMOSSO DALL'ASSOCIAZIONE PER LA PATOLOGIA CARDIOVASCOLARE ITALIANA

Author

LEONE, ORNELLA, RAPEZZI, CLAUDIO, PRANDSTRALLER, DANIELA, Sinagra G, Angelini A, Arbustini E, Bartoloni G, Basso C, Caforio AL, Calabrese F, Coccolo F, d'Amati G, Mariesi E, Milanesi O, Nodari S, Oliva F, Perkan A, Pucci A, Ramondo A, Silvestri F, Valente M, Thiene G, Federazione Italiana di Cardiologia Associazione per la Patologia Cardiovascolare Italiana, Leone O, Rapezzi C, Sinagra G, Angelini A, Arbustini E, Bartoloni G, Basso C, Caforio AL, Calabrese F, Coccolo F, d'Amati G, Mariesi E, Milanesi O, Nodari S, Oliva F, Perkan A, Prandstraller D, Pucci A, Ramondo A, Silvestri F, Valente M, Thiene G, and Federazione Italiana di Cardiologia Associazione per la Patologia Cardiovascolare Italiana.

Published
2009

16. A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM Risk-SCD)

Author

O'Mahony, C. Jichi, F. Pavlou, M. Monserrat, L. Anastasakis, A. Rapezzi, C. Biagini, E. Gimeno, J.R. Limongelli, G. McKenna, W.J. Omar, R.Z. Elliott, P.M. Ortiz-Genga, M. Fernandez, X. Vlagouli, V. Stefanadis, C. Coccolo, F. Sandoval, M.J.O. Pacileo, G. Masarone, D. Pantazis, A. Tome-Esteban, M. Dickie, S. Lambiase, P.D. Rahman, S.

Abstract

Aims: Hypertrophic cardiomyopathy(HCM)is a leading cause of sudden cardiac death (SCD) in young adults. Current risk algorithms provide only a crude estimate of risk and fail to account for the different effect size of individual risk factors. The aim of this study was to develop and validate a new SCD risk prediction model that provides individualized risk estimates. Methods and results: The prognostic model was derived from a retrospective, multi-centre longitudinal cohort study. The model was developed fromthe entire data set using theCox proportional hazards model and internally validated using bootstrapping. The cohort consisted of 3675 consecutive patients from six centres. During a follow-up period of 24 313 patient-years (median 5.7 years), 198 patients (5%) died suddenly or had an appropriate implantable cardioverter defibrillator (ICD) shock. Of eight pre-specified predictors, age, maximal left ventricular wall thickness, left atrial diameter, left ventricular outflow tract gradient, family history of SCD, non-sustained ventricular tachycardia, and unexplained syncope were associated with SCD/appropriate ICD shock at the 15% significance level. These predictors were included in the final model to estimate individual probabilities of SCD at 5 years. The calibration slope was 0.91 (95% CI: 0.74, 1.08), C-index was 0.70 (95% CI: 0.68, 0.72), and D-statistic was 1.07 (95% CI: 0.81, 1.32). For every 16 ICDs implanted in patients with ≥4% 5-year SCD risk, potentially 1 patient will be saved from SCD at 5 years. A second model with the data set split into independent development and validation cohorts had very similar estimates of coefficients and performance when externally validated. Conclusion: This is the first validatedSCDrisk prediction model for patients withHCMand provides accurate individualized estimates for the probability of SCD using readily collected clinical parameters. ©The Author 2013.

Published
2014

17. Age and heart transplantation: results from a heart failure management unit

Author

GRIGIONI, FRANCESCO, RUSSO, ANTONIO, ARPESELLA, GIORGIO, RAPEZZI, CLAUDIO, BRANZI, ANGELO, Potena L., Barbieri A., Bianchi G., Reggianini L., Fallani F., Magnani G., Coccolo F., Modena M. G., Grigioni F., Potena L., Barbieri A., Bianchi G., Reggianini L., Russo A, Fallani F., Magnani G., Coccolo F., Arpesella G., Rapezzi C., Modena M.G., and Branzi A.

Subjects
Adult, Heart Failure, Male, Age Factors, Myocardial Ischemia, Kaplan-Meier Estimate, Middle Aged, Prognosis, Adult Age Factors Aged Cohort Studies Female Heart Failure/complications, Cohort Studies, Italy, heart transplantation, Age, Heart Transplantation, Humans, Female, Aged, Retrospective Studies
Abstract

BACKGROUND: More evidence is needed to assess the pros and cons of maintaining age-limit policies in heart transplantation (HT). METHODS: We analyzed clinical data from a heart failure management unit to investigate the impact of age on prognosis of two distinct cohorts: (i) 309 patients (median age, 57 yr; 62% male) with severe chronic heart failure (CHF) consecutively screened for HT; (ii) 336 HT recipients (median age 56 yr, 82% male). RESULTS: In CHF patients (screened for HT), prognosis was conditioned by the underlying severity of cardiac disease (i.e., New York Heart Association class III-IV, decreasing blood pressure, presence of atrial fibrillation and severe mitral regurgitation), whereas increasing age showed no sign of predicting all-cause or cardiovascular mortality (both p > or = 0.4). In HT recipients, age did not retain significance at multivariate analysis as an independent predictor (p > or = 0.14 for both all-cause and cardiovascular death), whereas ischemic etiology of pre-existing CHF did (p < or = 0.02). CONCLUSIONS: Age did not appear to be a primary determinant of all-cause or cardiovascular mortality among potential HT candidates or eventual recipients (ischemic etiology of CHF turned out to be the major determinant of post-transplant outcome). These results support the concept that HT may be considered a treatment option in patients with more advanced age strata, particularly when affected by non-ischemic cardiomyopathy.

Published
2008

20. Diagnosi non invasiva di rigetto miocardico acuto: l'analisi armonica dell'ecg coadiuva la valutazione clinica

Author

Fabbri F, Fabbri S, Morjan M, Coccolo F, Magnani G, Fallani F, POTENA, LUCIANO, CORAZZA, IVAN, CARIGI, SAMUELA, MUSURACA, ANNA CHIARA, BIGLIARDI, MAURO, LEONE, ORNELLA, GRIGIONI, FRANCESCO, MAGELLI, CARLO, ZANNOLI, ROMANO, BRANZI, ANGELO, NICOLOSI GL, Fabbri F, Fabbri S, Morjan M, Potena L, Corazza I, Carigi S, Musuraca AC, Bigliardi M, Leone O, Grigioni F, Coccolo F, Magnani G, Fallani F, Magelli C, Zannoli R, and Branzi A.

Published
2005

21. Studio prospettico randomizzato sull'effetto della terapia con acido folico nella preenzione della malattia coronarica nel paziente trapiantato

Author

CARIGI, SAMUELA, POTENA, LUCIANO, RUSSO, ANTONIO, MUSURACA, ANNA CHIARA, BIGLIARDI, MAURO, GRIGIONI, FRANCESCO, MAGELLI, CARLO, BRANZI, ANGELO, Fabbri F, Ortolani P, Coccolo F, Magnani G, Fallani F, NICOLOSI GL, Carigi S, Potena L, Russo A, Musuraca AC, Fabbri F, Bigliardi M, Ortolani P, Grigioni F, Coccolo F, Magnani G, Fallani F, Magelli C, and Branzi A.

Published
2005

22. Genetic Basis of Pulmonary Arterial Hypertension Current Understanding and Future Directions

Author

NEWMAN J. H., TREMBATH R. C., MORSE J. A., GRUNIG E., LOYD J. E., ADNOT S., COCCOLO F., PHILLIPS III J. A., KNOWLES J. A., JANSSEN B., EICKELBERG O., EDDAHIBI S., HERVE P., NICHOLS W. C., ELLIOTT G., VENTURA, CARLO, NEWMAN J.H., TREMBATH R.C., MORSE J.A., GRUNIG E., LOYD J.E., ADNOT S., COCCOLO F., VENTURA C., PHILLIPS III J.A., KNOWLES J.A., JANSSEN B., EICKELBERG O., EDDAHIBI S., HERVE P., NICHOLS W.C., and ELLIOTT G.

Published
2004

23. Qualità della vita e parametri clinico-strumentali nello scompenso cardiaco

Author

Fabbri F, Coccolo F, Magnani G, CARIGI, SAMUELA, MUSURACA, ANNA CHIARA, RUSSO, ANTONIO, POTENA, LUCIANO, GRIGIONI, FRANCESCO, MAGELLI, CARLO, BRANZI, ANGELO, NICOLOSI GL, Fabbri F, Carigi S, Musuraca AC, Russo A, Potena L, Grigioni F, Coccolo F, Magnani G, Magelli C, and Branzi A.

Published
2004

25. Cytomegalovirus infectious burden is proportional to cardiac allograft vasculopathy in heart transplant recipients

Author

POTENA, LUCIANO, MAGELLI, CARLO, Ortolani P, Fearon WF, GRIGIONI, FRANCESCO, Magnani G, Coccolo F, Yeung AC, Luikart HI, Hunt SA, Mocarski ES, Cooke JP, Lewis DB, BRANZI, ANGELO, Valantine HA, DEMARIA, Potena L, Magelli C, Ortolani P, Fearon WF, Grigioni F, Magnani G, Coccolo F, Yeung AC, Luikart HI, Hunt SA, Mocarski ES, Cooke JP, Lewis DB, Branzi A, and Valantine HA

Subjects
Cardiovascular Diseases, Cardiology
Published
2004

28. [Consensus document on endomyocardial biopsy of theAssociazione per la Patologia Cardiovascolare Italiana]

Author

Leone, O, Rapezzi, C, Sinagra, G, Angelini, Annalisa, Arbustini, E, Bartoloni, G, Basso, Cristina, Caforio, Al, Calabrese, Fiorella, Coccolo, F, D'Amati, G, Mariesi, E, Milanesi, Ornella, Nodari, S, Oliva, F, Perkan, A, Prandstraller, D, Pucci, A, Ramondo, A, Silvestri, F, Valente, Marialuisa, Thiene, Gaetano, FEDERAZIONE ITALIANA DI CARDIOLOGIA, ASSOCIAZIONE PER LA PATOLOGIA, and Cardiovascolare, Italiana

Subjects
endomyocardial biopsy, consensus
Published
2009

30. 491 Differential Effect of Everolimus and Metabolic Risk Factors on Early vs. Late Progression of Allograft Vasculopathy: Dissecting Two Faces of the Same Disease

Author

Masetti, M., primary, Potena, L., additional, Nardozza, M., additional, Prestinenzi, P., additional, Pece, V., additional, Taglieri, N., additional, Saia, F., additional, Magnani, G., additional, Coccolo, F., additional, Fallani, F., additional, Grigioni, F., additional, and Branzi, A., additional

Published
2012
Full Text
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31. 206 Improvement of Renal Function after Cyclosporine Reduction Is Influenced by Baseline Proteinuria in Patients Converted to Everolimus: Long Term Follow-Up of the Shirakiss Randomized Study

Author

Prestinenzi, P., primary, Potena, L., additional, Bianchi, I.G., additional, Masetti, M., additional, Romani, P., additional, Magnani, G., additional, Fallani, F., additional, Coccolo, F., additional, Russo, A., additional, Grigioni, F., additional, and Branzi, A., additional

Published
2011
Full Text
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40. M.P.1.14 Asymptomatic mitochondrial myopathy with mtDNA multiple deletions revealed by propofol-induced multiple organ failure with rhabdomyolysis

Author

Carroccia, R., primary, Rinaldi, R., additional, Cenacchi, G., additional, Badiali De Giorgi, L., additional, Tarantino, L., additional, Valentino, M., additional, Baldin, E., additional, Pizza, F., additional, La Morgia, C., additional, Coccolo, F., additional, Zavatta, M., additional, Santoro, A., additional, and Carelli, V., additional

Published
2007
Full Text
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45. Cytomegalovirus burden and progressive severity of cardiac allograft vasculopathy

Author

Potena, L, primary, Magelli, C, additional, Fearon, W.F, additional, Yeung, A.C, additional, Coccolo, F, additional, Magnani, G, additional, Grigioni, F, additional, Ortolani, P, additional, Luikart, H.I, additional, Hunt, S.A, additional, Mocarski, E.S, additional, Cooke, J.P, additional, Lewis, D.B, additional, Branzi, A, additional, and Valantine, H.A, additional

Published
2004
Full Text
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50. Haemochromatosis gene mutations in idiopathic dilated cardiomyopathy

Author

Houlston, R., Mahon, N.G., Coonar, A.S., Coccolo, F., Akiyu, J., Zal, B., Baboonian, C., McKenna, W.J., Jeffery, S., and Levin, G.E.

Abstract

BackgroundTwo common mutations of the haemochromatosis associated gene (HFE) (cys282tyr (C282Y) and his63asp (H63D)) have been implicated in haemochromatosis and as modulators in cardiovascular disease.ObjectiveTo investigate the role of these mutations in the pathogenesis of idiopathic dilated cardiomyopathy.Design and settingCase-control and prospective cohort study of patients attending a cardiomyopathy unit in a tertiary referral cardiac centre.Methods207 unrelated white patients with dilated cardiomyopathy, followed up for 259 patient years, and 200 controls were tested for HFE C282Y and H63D mutations by polymerase chain reaction and restriction digestion.Results31/207 patients (15%) v 24/200 controls (12%) carried C282Y (adjusted odds ratio (OR) 1.2 (95% confidence interval 0.7 to 2.2)), 74/207 (36%) v 53/200 (27%) carried H63D (OR 1.6 (1.1 to 2.5)), and 10/207 (4.8%) v 4/200 (2%) were compound heterozygotes (OR 2.6 (0.8 to 8.5)). Four patients and six controls were H63D homozygous and one was C282Y homozygous. There was a progressive increase in mean serum iron ([Fe]) and transferrin saturations from patients with no mutation ([Fe] = 16.3 μmol/l, transferrin saturation = 23.7%) through H63D heterozygotes (17.5 μmol/l, 25.8%), C282Y heterozygotes (17.1 μmol/l, 26.6%), H63D homozygotes (20.0 μmol/l, 33.5%), compound heterozygotes (26.8 μmol/l, 41.7%), and C282Y homozygotes (34 μmol/l, 71%). At follow up (median 90 months) the rate of death or cardiac transplantation was 52/207 (25%). C282Y heterozygotes had less ventricular dilatation (mean (SD): 59.9 (1.7) mm v 64.9 (0.9) mm, p &lt; 0.05), better fractional shortening (24 (1.7)% v 18.8 (1.4)%, p &lt; 0.01), and a trend towards improved survival without transplantation. [Fe] and transferrin saturation did not correlate with disease severity and were not associated with reduced survival.ConclusionsThe frequency of the H63D mutation is significantly increased in patients with idiopathic dilated cardiomyopathy. As H63D has a relatively minor effect on iron status, the mechanism of this association may be unrelated to iron metabolism.

Published
2000

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