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1. Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency

Author

Agnieszka Dorman, Maryam Bendoumou, Aurelija Valaitienė, Jakub Wadas, Haider Ali, Antoine Dutilleul, Paolo Maiuri, Lorena Nestola, Monika Bociaga-Jasik, Gilbert Mchantaf, Coca Necsoi, Stéphane De Wit, Véronique Avettand-Fenoël, Alessandro Marcello, Krzysztof Pyrc, Alexander O. Pasternak, Carine Van Lint, and Anna Kula-Pacurar

Subjects
Science
Abstract

Abstract HIV-1 latency is mainly characterized at transcriptional level, and little is known about post-transcriptional mechanisms and their contribution to reactivation. The viral protein Rev controls the nucleocytoplasmic export of unspliced and singly-spliced RNA that is central to proviral replication-competence and is therefore a prerequisite for efficient viral reactivation during the “shock-and-kill” cure therapy. Here we show that during infection and reactivation, unspliced HIV-1 RNA is a subject to complex and dynamic regulation by the Rev cofactor MATR3 and the MTR4 cofactor of the nuclear exosome. MATR3 and MTR4 coexist in the same ribonucleoprotein complex functioning to either maintain or degrade the RNA, respectively, with Rev orchestrating this regulatory switch. Moreover, we provide evidence of nuclear retention of unspliced HIV-1 RNA in ex vivo cultures from 22 ART-treated people with HIV, highlighting a reversible post-transcriptional block to viral RNA nucleocytoplasmic export that is relevant to the design of curative interventions.

Published
2025
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2. Staging of immuno-virological dynamics during acute HIV infection in a Belgian prospective cohort study

Author

Jozefien De Clercq, Marie-Angélique De Scheerder, Sophie Vanherrewege, Els Caluwé, Nathalie Moreels, Danny Delooze, Annemieke Dhondt, Marc Coppens, Stefaan J. Vandecasteele, Sabine D. Allard, Coca Necsoi, Stéphane De Wit, Sarah Gerlo, and Linos Vandekerckhove

Subjects
HIV-1, Acute HIV infection, Antiretroviral therapy, Immunovirological outcomes, Human bodily material sampling, Microbiology, QR1-502, Public aspects of medicine, RA1-1270
Abstract

Background: The events during acute HIV infection (AHI) set the stage for the subsequent course of the disease. Early initiation of antiretroviral therapy (ART) has been associated with favorable immunovirological outcomes, yet the precise impact of ART timing during AHI remains unclear, particularly on lymphoid tissues. Materials and methods: The ACS cohort is a prospective cohort study in Belgium, collecting longitudinal clinical data and human bodily material (HBM) from people diagnosed and treated during AHI. The aim of the cohort is to study the impact of ART initiation during AHI on HIV reservoir and immune dysfunction in peripheral blood and anatomical sanctuary sites, as well as its effect on the gut microbiome. The cohort consists of two HBM sampling trajectories: one limited (blood, stool and leukapheresis) and a more extensive one (blood, stool, leukapheresis, colonoscopy, inguinal lymph node excision and lumbar puncture). Here we describe the baseline characteristics, immunovirological outcomes, safety and tolerability of HBM sampling. Results: Between March 2016 and April 2024, 47 participants were enrolled, predominantly men who have sex with men (MSM), with a median age of 36 years [IQR 30–43.5]. Almost 90 % of participants initiated ART within 72 h after study inclusion, irrespective of HBM sampling trajectory. The timing of ART initiation according to the Fiebig stage did not significantly impact immune recovery (CD4/CD8 ratio ≥1) or the time to viral suppression. Approximately 40 % of participants opted for the extensive HBM sampling trajectory during AHI. However, the participation rate for the extensive trajectory decreased by nearly half at the longitudinal follow-up timepoint. In general, study-related procedures were safe and well-tolerated, with limited procedure-related adverse events (AEs). Inguinal lymph node excision was associated with the highest AE rate, in line with previous reports. Conclusions: Our findings reaffirm the beneficial effect of ART initiation during AHI on long term immunovirological outcomes, regardless of Fiebig stage at treatment initiation. Additionally, we demonstrate that the collection of HBM during and longitudinally after AHI is safe and feasible, without compromising time to ART initiation. Cohorts that integrate comprehensive clinical data with high-quality HBM samples are essential to longitudinally study the impact of early ART on reservoir dynamics and immune responses across various anatomical sites after AHI.

Published
2024
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3. HIV-related immune activation attenuates polyfunctional IgG and memory B-cell responses to Tdap immunization during pregnancyResearch in context

Author

Martin Taton, Fabienne Willems, Cyprien Widomski, Daphnée Georges, Charlotte Martin, Yiwei Jiang, Katty Renard, Deborah Konopnicki, Alexandra Cogan, Coca Necsoi, André Matagne, Stéphane De Wit, Margaret E. Ackerman, Arnaud Marchant, and Nicolas Dauby

Subjects
Pertussis, Pregnancy, HIV, Vaccination, Polyfunctional IgG, Memory B cells, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: Maternal pertussis vaccination with Tdap vaccine is recommended to protect newborns from severe postnatal infection. HIV-exposed uninfected (HEU) infants have a higher incidence of pertussis infection and may particularly benefit from maternal immunization. The impact of HIV infection on the quality of IgG and memory B cell (MBC) responses to Tdap vaccination in pregnant women (PW) living with HIV (PWH) is unknown. Methods: In this observational study, humoral immune responses to Tdap vaccination, including IgG levels, Fc-dependent effector functions, and MBC frequencies, were measured before and after vaccination in 40 PWH and 42 HIV-uninfected PW. Placental transfer of IgG and avidity were assessed in cord blood (CB). Soluble and cellular immune activation markers were quantified at baseline. Findings: One month after vaccination, PWH had lower frequencies of MBC compared with HIV-uninfected PW. At delivery, PWH had attenuated pertussis-specific IgG levels and Fc-dependent effector functions. Reduced levels of maternal vaccine polyfunctional IgG and IgG avidity were transferred to HEU as compared to HIV-unexposed newborns. After adjustment with ethnicity, maternal antibody levels and gestational age at vaccination, HIV infection was independently associated with decreased levels of PT specific-IgG in CB. Both maternal and neonatal pertussis-specific IgG responses as well as PT-specific IgG avidity were inversely correlated with maternal sCD14 levels before vaccination among PWH. Interpretation: Maternal HIV infection is associated with attenuated humoral immune responses to Tdap vaccination that correlate with sCD14. Suboptimal transfer of maternal immunity may further increase the risk of severe pertussis infection in HEU infants. Funding: This work was supported by IRIS Fund managed by the Foundation Roi Baudouin [2017J1820690206902], Association Vésale pour la Recherche Médicale and the Medical Council of CHU Saint-Pierre and has been funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Department of Health and Human Services, under Award No. U19AI145825. N.D. is a clinical researcher and A.M. is Research Director at the Fonds de la Recherche Scientifique (F.R.S.-FNRS), Belgium. M.E.A. was partially supported by NIH NIAID 1U19AI14825. This article is published with the support of the Fondation Universitaire of Belgium.

Published
2024
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4. Longitudinal patterns of inflammatory mediators after acute HIV infection correlate to intact and total reservoir

Author

Jozefien De Clercq, Marie-Angélique De Scheerder, Virginie Mortier, Chris Verhofstede, Stefaan J. Vandecasteele, Sabine D. Allard, Coca Necsoi, Stéphane De Wit, Sarah Gerlo, and Linos Vandekerckhove

Subjects
acute HIV infection, inflammation, plasma soluble mediators, cytokines, chemokines, early ART, Immunologic diseases. Allergy, RC581-607
Abstract

BackgroundDespite the beneficial effects of antiretroviral therapy (ART) initiation during acute HIV infection (AHI), residual immune activation remains a hallmark of treated HIV infection.MethodsPlasma concentrations of 40 mediators were measured longitudinally in 39 early treated participants of a Belgian AHI cohort (HIV+) and in 21 HIV-negative controls (HIV-). We investigated the association of the inflammatory profile with clinical presentation, plasma viral load, immunological parameters, and in-depth characterization of the HIV reservoir.ResultsWhile levels of most soluble mediators normalized with suppressive ART, we demonstrated the persistence of a pro-inflammatory signature in early treated HIV+ participants in comparison to HIV- controls. Examination of these mediators demonstrated a correlation with their levels during AHI, which seemed to be viremia-driven, and suggested involvement of an activated myeloid compartment, IFN-γ-signaling, and inflammasome-related pathways. Interestingly, some of these pro-inflammatory mediators correlated with a larger reservoir size and slower reservoir decay. In contrast, we also identified soluble mediators which were associated with favorable effects on immunovirological outcomes and reservoir, both during and after AHI.ConclusionThese data highlight how the persistent pro-inflammatory profile observed in early ART treated individuals is shaped during AHI and is intertwined with viral dynamics

Published
2024
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5. Novel role of UHRF1 in the epigenetic repression of the latent HIV-1

Author

Roxane Verdikt, Maryam Bendoumou, Sophie Bouchat, Lorena Nestola, Alexander O. Pasternak, Gilles Darcis, Véronique Avettand-Fenoel, Caroline Vanhulle, Amina Aït-Ammar, Marion Santangelo, Estelle Plant, Valentin Le Douce, Nadège Delacourt, Aurelija Cicilionytė, Coca Necsoi, Francis Corazza, Caroline Pereira Bittencourt Passaes, Christian Schwartz, Martin Bizet, François Fuks, Asier Sáez-Cirión, Christine Rouzioux, Stéphane De Wit, Ben Berkhout, Virginie Gautier, Olivier Rohr, and Carine Van Lint

Subjects
HIV-1 latency, Reactivation, UHRF1, Epigenetics, EGCG, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1. Accordingly, all classes of latency-reversing agents (LRAs) have been reported to present variable ex vivo potencies. Here, we investigated the molecular mechanisms underlying the potency variability of one LRA: the DNA methylation inhibitor 5-aza-2’-deoxycytidine (5-AzadC). Methods: We employed epigenetic interrogation methods (electrophoretic mobility shift assays, chromatin immunoprecipitation, Infinium array) in complementary HIV-1 infection models (latently-infected T-cell line models, primary CD4+ T-cell models and ex vivo cultures of PBMCs from HIV+ individuals). Extracellular staining of cell surface receptors and intracellular metabolic activity were measured in drug-treated cells. HIV-1 expression in reactivation studies was explored by combining the measures of capsid p24Gag protein, green fluorescence protein signal, intracellular and extracellular viral RNA and viral DNA. Findings: We uncovered specific demethylation CpG signatures induced by 5-AzadC in the HIV-1 promoter. By analyzing the binding modalities to these CpG, we revealed the recruitment of the epigenetic integrator Ubiquitin-like with PHD and RING finger domain 1 (UHRF1) to the HIV-1 promoter. We showed that UHRF1 redundantly binds to the HIV-1 promoter with different binding modalities where DNA methylation was either non-essential, essential or enhancing UHRF1 binding. We further demonstrated the role of UHRF1 in the epigenetic repression of the latent viral promoter by a concerted control of DNA and histone methylations. Interpretation: A better understanding of the molecular mechanisms of HIV-1 latency allows for the development of innovative antiviral strategies. As a proof-of-concept, we showed that pharmacological inhibition of UHRF1 in ex vivo HIV+ patient cell cultures resulted in potent viral reactivation from latency. Together, we identify UHRF1 as a novel actor in HIV-1 epigenetic silencing and highlight that it constitutes a new molecular target for HIV-1 cure strategies. Funding: Funding was provided by the Belgian National Fund for Scientific Research (F.R.S.-FNRS, Belgium), the « Fondation Roi Baudouin », the NEAT (European AIDS Treatment Network) program, the Internationale Brachet Stiftung, ViiV Healthcare, the Télévie, the Walloon Region (« Fonds de Maturation »), « Les Amis des Instituts Pasteur à Bruxelles, asbl », the University of Brussels (Action de Recherche Concertée ULB grant), the Marie Skodowska Curie COFUND action European Union's Horizon 2020 research and innovation program under grant agreement No 691119-EU4HIVCURE-H2020-MSCA-RISE-2015, the French Agency for Research on AIDS and Viral Hepatitis (ANRS), the Sidaction and the “Alsace contre le Cancer” Foundation. This work is supported by 1UM1AI164562-01, co-funded by National Heart, Lung and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute on Drug Abuse and the National Institute of Allergy and Infectious Diseases.

Published
2022
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6. Virologic and immunologic outcomes of treatment with integrase inhibitors in a real-world setting: The RESPOND cohort consortium.

Author

Bastian Neesgaard, Amanda Mocroft, Robert Zangerle, Ferdinand Wit, Fiona Lampe, Huldrych F Günthard, Coca Necsoi, Matthew Law, Cristina Mussini, Antonella Castagna, Antonella d'Arminio Monforte, Christian Pradier, Nikoloz Chkhartisvilli, Juliana Reyes-Uruena, Jörg Janne Vehreschild, Jan-Christian Wasmuth, Anders Sönnerborg, Christoph Stephan, Lauren Greenberg, Josep M Llibre, Alain Volny-Anne, Lars Peters, Annegret Pelchen-Matthews, Vani Vannappagari, Joel Gallant, Armin Rieger, Mike Youle, Dominique Braun, Stephane De Wit, Kathy Petoumenos, Vanni Borghi, Vincenzo Spagnuolo, Tengiz Tsertsvadze, Jens Lundgren, Lene Ryom, and RESPOND study group

Subjects
Medicine, Science
Abstract

ObjectivesTo compare virologic and immunologic outcomes of integrase inhibitor (INSTI)-containing, contemporary boosted protease inhibitor (PI/b)-containing and non-nucleotide reverse transcriptase inhibitor (NNRTI)-containing regimens in a real-life setting.MethodsUsing logistic regression, virologic and immunologic outcomes of INSTI use were compared to outcomes of PI/b or NNRTI treatment 12 months after treatment start or switch, for participants in the RESPOND cohort consortium. A composite treatment outcome (cTO) was used, defining success as viral load (VL) ResultsBetween January 2012 and January 2019, 13,703 (33.0% ART-naïve) individuals were included, of whom 7,147 started/switched to a regimen with an INSTI, 3,102 to a PI/b and 3,454 to an NNRTI-containing regimen. The main reason for cTO failure in all treatment groups were changes in ART regimen. Compared to INSTIs, the adjusted odds ratio (aOR) of cTO success was significantly lower for PI/b (0.74 [95% confidence interval, CI 0.67-0.82], p ConclusionIn this large analysis of a real-world population, cTO and on-treatment success were similar between INSTIs and NNRTIs, but lower for PI/b, though residual confounding cannot be fully excluded. Obtaining favorable immunologic outcomes were more likely for INSTIs than the other drug classes.

Published
2020
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7. Qualitative plasma viral load determination as a tool for screening of viral reservoir size in PWH

Author

Thessa Laeremans, Sigrid D’haese, Jonathan Aernout, Kurt Barbé, Pieter Pannus, Sofie Rutsaert, Ellen Vancutsem, Guido Vanham, Coca Necsoi, Ward De Spiegelaere, Marie Couttenye, Natacha Herssens, Marie-Angélique De Scheerder, Stéphane De Wit, Linos Vandekerckhove, Eric Florence, Joeri L. Aerts, Sabine D. Allard, Neuro-Aging & Viro-Immunotherapy, Faculty of Medicine and Pharmacy, Pharmaceutical and Pharmacological Sciences, Radiation Therapy, Artificial Intelligence supported Modelling in clinical Sciences, Biostatistics and medical informatics, Digital Mathematics, Public Health Sciences, Supporting clinical sciences, Microbiology and Infection Control, Clinical Biology, Internal Medicine, and Clinical sciences

Subjects
Immunology, HIV Infections/drug therapy, Health Informatics, HIV Infections, Viral Load, Plasma/chemistry, Plasma, Infectious Diseases, DNA, Viral, DNA, Viral/analysis, Internal Medicine, Leukocytes, Mononuclear, Humans, RNA, RNA, Viral, Immunology and Allergy, Human medicine
Abstract

Objective(s): Suppression of viral replication in patients on antiretroviral therapy (ART) is determined by plasma viral load (pVL) measurement. Whenever pVL reaches values below the limit of quantification, the qualitative parameter 'target detected' or 'target not detected' is available but often not reported to the clinician. We investigated whether qualitative pVL measurements can be used to estimate the viral reservoir size. Design: The study recruited 114 people with HIV (PWH) who are stable on ART between 2016 and 2018. The percentage of pVL measurements qualitatively reported as 'target detected' (PTD) within a 2-year period was calculated. Methods: t-DNA and US-RNA were used to estimate viral reservoir size and were quantified on peripheral blood mononuclear cells (PBMCs) using droplet digital PCR. Results: A median of 6.5 pVL measurements over a 2-year period was evaluated for each participant to calculate PTD. A positive correlation was found between t-DNA and PTD (r = 0.24; P = 0.011) but not between US-RNA and PTD (r = 0.1; P = 0.3). A significantly lower PTD was observed in PWH with a small viral reservoir, as estimated by t-DNA less than 66 copies/10(6) PBMCs and US-RNA less than 10 copies/10(6) PBMCs, compared with PWH with a larger viral reservoir (P = 0.001). We also show that t-DNA is detectable whenever PTD is higher than 56% and that ART regimen does not affect PTD. Conclusion: Our study shows that PTD provides an efficient parameter to preselect participants with a small viral reservoir based on already available pVL data for future HIV cure trials.

Published
2022
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8. Associations between integrase strand-transfer inhibitors and cardiovascular disease in people living with HIV

Author

Bastian Neesgaard, Lauren Greenberg, Jose M Miró, Katharina Grabmeier-Pfistershammer, Gilles Wandeler, Colette Smith, Stéphane De Wit, Ferdinand Wit, Annegret Pelchen-Matthews, Cristina Mussini, Antonella Castagna, Christian Pradier, Antonella d'Arminio Monforte, Jörg J Vehreschild, Anders Sönnerborg, Alain V Anne, Andrew Carr, Loveleen Bansi-Matharu, Jens D Lundgren, Harmony Garges, Felipe Rogatto, Robert Zangerle, Huldrych F Günthard, Line D Rasmussen, Coca Necsoi, Marc van der Valk, Marianna Menozzi, Camilla Muccini, Lars Peters, Amanda Mocroft, Lene Ryom, Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, APH - Digital Health, APH - Personalized Medicine, and APH - Global Health

Subjects
Adult, Male, Acquired Immunodeficiency Syndrome, Integrases, Epidemiology, Immunology, Australia, HIV Infections, Middle Aged, Cohort Studies, Infectious Diseases, Cardiovascular Diseases, Virology, Humans, Female, HIV Integrase Inhibitors, Prospective Studies, 610 Medicine & health
Abstract

BACKGROUND Although associations between older antiretroviral drug classes and cardiovascular disease in people living with HIV are well described, there is a paucity of data regarding a possible association with integrase strand-transfer inhibitors (INSTIs). We investigated whether exposure to INSTIs was associated with an increased incidence of cardiovascular disease. METHODS RESPOND is a prospective, multicentre, collaboration study between 17 pre-existing European and Australian cohorts and includes more than 32 000 adults living with HIV in clinical care after Jan 1, 2012. Individuals were eligible for inclusion in these analyses if they were older than 18 years, had CD4 cell counts and HIV viral load measurements in the 12 months before or within 3 months after baseline (latest of cohort enrolment or Jan 1, 2012), and had no exposure to INSTIs before baseline. These individuals were subsequently followed up to the earliest of the first cardiovascular disease event (ie, myocardial infarction, stroke, or invasive cardiovascular procedure), last follow-up, or Dec 31, 2019. We used multivariable negative binomial regression to assess associations between cardiovascular disease and INSTI exposure (0 months [no exposure] vs >0 to 6 months, >6 to 12 months, >12 to 24 months, >24 to 36 months, and >36 months), adjusted for cardiovascular risk factors. RESPOND is registered with ClinicalTrials.gov, NCT04090151, and is ongoing. FINDINGS 29 340 people living with HIV were included in these analyses, of whom 7478 (25·5%) were female, 21 818 (74·4%) were male, and 44 (24 to 36 months of exposure). Compared with those with no INSTI exposure, the risk of cardiovascular disease was increased in the first 24 months of INSTI exposure and thereafter decreased to levels similar to those never exposed (>0 to 6 months of exposure: adjusted incidence rate ratio of 1·85 [1·44-2·39]; >6 to 12 months of exposure: 1·19 [0·84-1·68]; >12 to 24 months of exposure: 1·46 [1·13-1·88]; >24 to 36 months of exposure: 0·89 [0·62-1·29]; and >36 months of exposure: 0·96 [0·69-1·33]; p

Published
2022

10. Durability of tetanus seroprotection in people living with HIV

Author

Nicolas Dauby, Cathy Gobert, Asma Benslimane, Carole Nagant, Coca Necsoi, Sigi van den Wijngaert, Francis Corazza, Marc Delforge, and Stéphane De Wit

Subjects
Cross-Sectional Studies, Tetanus, Infectious Diseases, Vaccination, Immunology, Immunization, Secondary, Tetanus Toxoid, Humans, Immunology and Allergy, HIV Infections, Antibodies, Bacterial, CD4 Lymphocyte Count
Abstract

The aim of this study was to estimate the durability of tetanus toxoid specific seroprotection in a cohort of people with HIV (PWH).A cross-sectional study.PWH with a last date of tetanus toxoid booster available were identified. Tetanus toxoid specific IgG were detected using commercial ELISA kit. Durability of seroprotection was estimated using a linear regression model and analyzed according to the country of birth. The impact of baseline parameters at the time of vaccination (CD4 + T cell count, viral load, and antiretroviral therapy) was also assessed.One hundred three individuals were included. The median duration between last tetanus toxoid booster and sampling was 5.6years (IQR 2.6-8.9). Using a linear regression model, half-life of tetanus toxoid specific antibody was estimated at 9.9 years [95% confidence interval (95% CI: 5.5-50)] in the whole cohort. Half-life was reduced in individuals born outside Europe: 4.4 years (95% CI: 2.9-8.5). PWH born outside Europe had lower CD4 + T cell count at the time of immunization and more frequently a CD4 + T cell count nadir less than 200 cells/μl before vaccination.PWH born outside Europe have lower half-life of tetanus toxoid specific antibody as compared to previous study performed in the general population. Possible causes include lower nadir or current CD4 + T cell count or under-immunization status in country of origin before migration. Longer interval of booster vaccination, as recommended in the general population, might not be appropriate in this subgroup of PWH. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Published
2022
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11. Tenofovir Alafenamide Plasma Concentrations Are Reduced in Pregnant Women Living With Human Immunodeficiency Virus (HIV): Data From the PANNA Network

Author

Vera E Bukkems, Coca Necsoi, Carmen Hidalgo Tenorio, Coral Garcia, Irene Alba Alejandre, Fabian Weiss, John S Lambert, Astrid van Hulzen, Olivier Richel, Lindsey H M te Brake, Eric van der Meulen, David Burger, Deborah Konopnicki, and Angela Colbers

Subjects
Microbiology (medical), Alanine, Anti-HIV Agents, Adenine, mother-to-child transmission, HIV, HIV Infections, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Infectious Diseases, Pregnancy, Humans, tenofovir alafenamide, Female, Pregnant Women, Tenofovir, pharmacokinetics
Abstract

Background Tenofovir alafenamide (TAF), a prodrug of tenofovir (TFV), is included in the majority of the recommended first-line antiretroviral regimens for patients living with human immunodeficiency virus (HIV), but there are limited data on TAF use in pregnant women. We aimed to examine the plasma pharmacokinetics of TAF and TFV in pregnant women from Europe. Methods Pregnant women living with HIV were included from treatment centers across Europe, and intensive pharmacokinetic sampling in the third trimester and postpartum was performed. Pharmacokinetic parameters of TAF and TFV were determined with noncompartmental analysis. The proportion of women with a TAF area under the curve (AUClast) below the target of 53.1 ng∗h/mL was determined. Clinical efficacy and safety outcome parameters were reported. Results In total, 20 pregnant women living with HIV were included. At the third trimester, geometric mean TAF AUClast and Cmax were decreased by 46% and 52%, respectively, compared with postpartum. TFV AUC0-24h, Cmax, and Ctrough decreased by 33%, 30%, and 34%, respectively. The proportion of women with a TAF AUClast 50 copies/mL at third trimester and no mother-to-child transmission occurred. Conclusions TAF plasma concentrations were reduced by about half in women living with HIV during third trimester of pregnancy but remained above the predefined efficacy target in the majority of the pregnant women. TFV concentrations were reduced by approximately 30% during third trimester. Despite the observed exposure decrease, high virologic efficacy was observed in this study.

Published
2022
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13. Integrase Strand Transfer Inhibitor Use and Cancer Incidence in a Large Cohort Setting

Author

Lauren, Greenberg, Lene, Ryom, Bastian, Neesgaard, Jose M, Miró, Line, Dahlerup Rasmussen, Robert, Zangerle, Katharina, Grabmeier-Pfistershammer, Huldrych F, Günthard, Katharina, Kusejko, Colette, Smith, Cristina, Mussini, Marianna, Menozzi, Ferdinand, Wit, Marc, Van Der Valk, Antonella, d'Arminio Monforte, Stéphane, De Wit, Coca, Necsoi, Annegret, Pelchen-Matthews, Jens, Lundgren, Lars, Peters, Antonella, Castagna, Camilla, Muccini, Jörg Janne, Vehreschild, Christian, Pradier, Andreu, Bruguera Riera, Anders, Sönnerborg, Kathy, Petoumenos, Harmony, Garges, Felipe, Rogatto, Nikos, Dedes, Loveleen, Bansi-Matharu, Amanda, Mocroft, D, Byonanebye, Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, APH - Digital Health, APH - Personalized Medicine, and APH - Global Health

Subjects
RISK, antiretroviral treatment, HIV-1 INFECTION, RALTEGRAVIR, HIV, cohort, TRENDS, DOUBLE-BLIND, Infectious Diseases, integrase inhibitors, Oncology, AIDS-DEFINING MALIGNANCIES, CHANGING PATTERNS, INITIAL TREATMENT, cancer, LIFE EXPECTANCY, COMBINATION ANTIRETROVIRAL THERAPY
Abstract

Background Limited data exist examining the association between incident cancer and cumulative integrase inhibitor (INSTI) exposure. Methods Participants were followed from baseline (latest of local cohort enrollment or January 1, 2012) until the earliest of first cancer, final follow-up, or December 31, 2019. Negative binomial regression was used to assess associations between cancer incidence and time-updated cumulative INSTI exposure, lagged by 6 months. Results Of 29 340 individuals, 74% were male, 24% were antiretroviral treatment (ART)-naive, and median baseline age was 44 years (interquartile range [IQR], 36–51). Overall, 13 950 (48%) individuals started an INSTI during follow-up. During 160 657 person-years of follow-up ([PYFU] median 6.2; IQR, 3.9–7.5), there were 1078 cancers (incidence rate [IR] 6.7/1000 PYFU; 95% confidence interval [CI], 6.3–7.1). The commonest cancers were non-Hodgkin lymphoma (n = 113), lung cancer (112), Kaposi’s sarcoma (106), and anal cancer (103). After adjusting for potential confounders, there was no association between cancer risk and INSTI exposure (≤6 months vs no exposure IR ratio: 1.15 [95% CI, 0.89–1.49], >6–12 months; 0.97 [95% CI, 0.71–1.32], >12–24 months; 0.84 [95% CI, 0.64–1.11], >24–36 months; 1.10 [95% CI, 0.82–1.47], >36 months; 0.90 [95% CI, 0.65–1.26] [P = .60]). In ART-naive participants, cancer incidence decreased with increasing INSTI exposure, mainly driven by a decreasing incidence of acquired immune deficiency syndrome cancers; however, there was no association between INSTI exposure and cancer for those ART-experienced (interaction P Conclusions Cancer incidence in each INSTI exposure group was similar, despite relatively wide CIs, providing reassuring early findings that increasing INSTI exposure is unlikely to be associated with an increased cancer risk, although longer follow-up is needed to confirm this finding.

Published
2021
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14. Role of Inflammatory Biomarkers in the Prevalence and Incidence of Hypertension Among HIV-Positive Participants in the START Trial

Author

Coca Necsoi, James D. Neaton, Shweta Sharma, Mamta K. Jain, Paul E. Drawz, Lama Ghazi, Adrian Palfreeman, Jason V. Baker, and Daniel D Murray

Subjects
Adult, Male, medicine.medical_specialty, Anti-HIV Agents, Original Contributions, Blood Pressure, HIV Infections, 030204 cardiovascular system & hematology, Risk Assessment, Drug Administration Schedule, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Diabetes mellitus, Prevalence, Internal Medicine, medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Interleukin-6, Proportional hazards model, business.industry, Incidence, Incidence (epidemiology), Hazard ratio, Middle Aged, medicine.disease, Confidence interval, C-Reactive Protein, Cross-Sectional Studies, Blood pressure, Hypertension, Biomarker (medicine), Female, Inflammation Mediators, business, Body mass index, Biomarkers
Abstract

BACKGROUND The association between hypertension (HTN) and inflammatory biomarkers (interleukin-6 [IL-6] and high-sensitivity C-reactive protein [hsCRP]) in HIV-positive persons with CD4+ count >500 cells/mm3 is unknown. METHODS We studied HTN in participants of the Strategic Timing of AntiRetroviral Treatment (START) trial of immediate vs. deferred antiretroviral therapy (ART) in HIV-positive, ART naive adults with CD4+ count > 500 cells/mm3. HTN was defined as having a systolic blood pressure (BP) ≥140 mmHg, a diastolic BP ≥90 mmHg, or using BP-lowering therapy. Logistic and discrete Cox regression models were used to study the association between baseline biomarker levels with prevalent and incident HTN. RESULTS Among 4,249 participants with no history of cardiovascular disease, the median age was 36 years, 55% were nonwhite, and the prevalence of HTN at baseline was 18.9%. After adjustment for race, age, gender, body mass index (BMI), diabetes, smoking, HIV RNA and CD4+ levels, associations of IL-6 and hsCRP with HTN prevalence were not significant (OR per twofold higher:1.10, 95% confidence interval [CI]: 0.99, 1.20 for IL-6 and 1.05, 95% CI: 0.99, 1.10 for hsCRP). Overall incidence of HTN was 6.8 cases/100 person years. In similarly adjusted models, neither IL-6 (Hazard ratios [HR] per twofold higher IL-6 levels: 0.97, 95% CI: 0.88, 1.08) nor hsCRP (HR per twofold higher hsCRP levels: 0.97, 95% CI: 0.92, 1.02) were associated with risk of incident HTN. Associations did not differ by treatment group. Age, race, gender, and BMI were significantly associated with both the prevalence and incidence of HTN. CONCLUSIONS Traditional risk factors and not baseline levels of IL-6 or hsCRP were associated with the prevalence and incidence of HTN in START.

Published
2019
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15. Screening HIV Patients at Risk for NAFLD Using MRI-PDFF and Transient Elastography: A European Multicenter Prospective Study

Author

Maud Lemoine, Lambert Assoumou, Pierre-Marie Girard, Marc Antoine Valantin, Christine Katlama, Stephane De Wit, Pauline Campa, Hayette Rougier, Jean-Luc Meynard, Coca Necsoi, Anja D. Huefner, Jan Van Luzen, Julian Schulze zur Wiesch, Jean-Philippe Bastard, Soraya Fellahi, Stefan Mauss, Metodi V. Stankov, Axel Baumgarten, Gerrit Post, Lawrence Serfaty, Vlad Ratziu, Yves Menu, Jerome Schlue, Pierre Bedossa, Jacqueline Capeau, Dominique Costagliola, Georg Behrens, and Patrick Ingiliz

Subjects
Hepatology, Gastroenterology
Abstract

Nonalcoholic fatty liver disease (NAFLD) is a growing concern in the aging population with human immunodeficiency virus (HIV). Screening for NAFLD is recommended in patients with metabolic risk factors or unexplained transaminitis. This study aimed to prospectively assess the prevalence and associated factors of liver steatosis and advanced fibrosis (AF) in HIV-monoinfected patients at risk of NAFLD.We conducted a multicenter study in HIV-monoinfected patients, nonexcessive drinkers with metabolic syndrome, and/or persistently elevated liver enzymes, and/or clinical lipodystrophy. All participants had magnetic resonance imaging proton density fat fraction (MRI-PDFF), Fibroscan/controlled attenuation parameter (CAP), and cytokine and genetic analysis.From March 2014 to November 2015, we enrolled 442 participants and analyzed 402: male (85%); median age, 55 years (interquartile range [IQR], 50-61 years); body mass index, 27.0 kg/mIn a large cohort of HIV-moninfected patients at risk of NAFLD, steatosis is present in two-thirds of cases, and around 10% have AF. The CAP technique is accurate for screening steatosis in this population.

Published
2021

16. The value of open-source clinical science in pandemic response: lessons from ISARIC

Author

Abbas, Ali, primary, Abdukahil, Sheryl Ann, additional, Abdulkadir, Nurul Najmee, additional, Abe, Ryuzo, additional, Abel, Laurent, additional, Absil, Lara, additional, Acharya, Subhash, additional, Acker, Andrew, additional, Adachi, Shingo, additional, Adam, Elisabeth, additional, Adrião, Diana, additional, Ageel, Saleh Al, additional, Ahmed, Shakeel, additional, Ain, Quratul, additional, Ainscough, Kate, additional, Aisa, Tharwat, additional, Ait Hssain, Ali, additional, Ait Tamlihat, Younes, additional, Akimoto, Takako, additional, Akmal, Ernita, additional, Al Qasim, Eman, additional, Alalqam, Razi, additional, Alam, Tanvir, additional, Al-dabbous, Tala, additional, Alegesan, Senthilkumar, additional, Alegre, Cynthia, additional, Alessi, Marta, additional, Alex, Beatrice, additional, Alexandre, Kévin, additional, Al-Fares, Abdulrahman, additional, Alfoudri, Huda, additional, Ali, Imran, additional, Ali Shah, Naseem, additional, Alidjnou, Kazali Enagnon, additional, Aliudin, Jeffrey, additional, Alkhafajee, Qabas, additional, Allavena, Clotilde, additional, Allou, Nathalie, additional, Altaf, Aneela, additional, Alves, João, additional, Alves, João Melo, additional, Alves, Rita, additional, Amaral, Maria, additional, Amira, Nur, additional, Ammerlaan, Heidi, additional, Ampaw, Phoebe, additional, Andini, Roberto, additional, Andrejak, Claire, additional, Angheben, Andrea, additional, Angoulvant, François, additional, Ansart, Séverine, additional, Anthonidass, Sivanesen, additional, Antonelli, Massimo, additional, Antunes de Brito, Carlos Alexandre, additional, Anwar, Kazi Rubayet, additional, Apriyana, Ardiyan, additional, Arabi, Yaseen, additional, Aragao, Irene, additional, Arali, Rajeshwari, additional, Arancibia, Francisco, additional, Araujo, Carolline, additional, Arcadipane, Antonio, additional, Archambault, Patrick, additional, Arenz, Lukas, additional, Arlet, Jean-Benoît, additional, Arnold-Day, Christel, additional, Aroca, Ana, additional, Arora, Lovkesh, additional, Arora, Rakesh, additional, Artaud-Macari, Elise, additional, Aryal, Diptesh, additional, Asaki, Motohiro, additional, Asensio, Angel, additional, Ashley, Elizabeth, additional, Ashraf, Muhammad, additional, Ashraf, Sheharyar, additional, Asim, Mohammad, additional, Assie, Jean Baptiste, additional, Asyraf, Amirul, additional, Atique, Anika, additional, Attanyake, AM Udara Lakshan, additional, Auchabie, Johann, additional, Aumaitre, Hugues, additional, Auvet, Adrien, additional, Azemar, Laurène, additional, Azoulay, Cecile, additional, Bach, Benjamin, additional, Bachelet, Delphine, additional, Badr, Claudine, additional, Baig, Nadia, additional, Baillie, J. Kenneth, additional, Baird, J Kevin, additional, Bak, Erica, additional, Bakakos, Agamemnon, additional, Bakar, Nazreen Abu, additional, Bal, Andriy, additional, Balakrishnan, Mohanaprasanth, additional, Balan, Valeria, additional, Bani-Sadr, Firouzé, additional, Barbalho, Renata, additional, Barbosa, Nicholas Yuri, additional, Barclay, Wendy S., additional, Barnett, Saef Umar, additional, Barnikel, Michaela, additional, Barrasa, Helena, additional, Barrelet, Audrey, additional, Barrigoto, Cleide, additional, Bartoli, Marie, additional, Bartone, Cheryl, additional, Baruch, Joaquín, additional, Bashir, Mustehan, additional, Basmaci, Romain, additional, Basri, Muhammad Fadhli Hassin, additional, Bastos, Diego, additional, Battaglini, Denise, additional, Bauer, Jules, additional, Bautista Rincon, Diego Fernando, additional, Bazan Dow, Denisse, additional, Bedossa, Alexandra, additional, Bee, Ker Hong, additional, Behilill, Sylvie, additional, Beishuizen, Albertus, additional, Beljantsev, Aleksandr, additional, Bellemare, David, additional, Beltrame, Anna, additional, Beltrão, Beatriz Amorim, additional, Beluze, Marine, additional, Benech, Nicolas, additional, Benjiman, Lionel Eric, additional, Benkerrou, Dehbia, additional, Bennett, Suzanne, additional, Bento, Luís, additional, Berdal, Jan-Erik, additional, Bergeaud, Delphine, additional, Bergin, Hazel, additional, Bernal Sobrino, José Luis, additional, Bertoli, Giulia, additional, Bertolino, Lorenzo, additional, Bessis, Simon, additional, Betz, Adam, additional, Bevilcaqua, Sybille, additional, Bezulier, Karine, additional, Bhatt, Amar, additional, Bhavsar, Krishna, additional, Bianchi, Isabella, additional, Bianco, Claudia, additional, Bidin, Farah Nadiah, additional, Bikram Singh, Moirangthem, additional, Bin Humaid, Felwa, additional, Bin Kamarudin, Mohd Nazlin, additional, Bissuel, François, additional, Biston, Patrick, additional, Bitker, Laurent, additional, Blanco-Schweizer, Pablo, additional, Blier, Catherine, additional, Bloos, Frank, additional, Blot, Mathieu, additional, Blumberg, Lucille, additional, Boccia, Filomena, additional, Bodenes, Laetitia, additional, Bogaarts, Alice, additional, Bogaert, Debby, additional, Boivin, Anne-Hélène, additional, Bolze, Pierre-Adrien, additional, Bompart, François, additional, Bonfasius, Aurelius, additional, Borges, Diogo, additional, Borie, Raphaël, additional, Bosse, Hans Martin, additional, Botelho-Nevers, Elisabeth, additional, Bouadma, Lila, additional, Bouchaud, Olivier, additional, Bouchez, Sabelline, additional, Bouhmani, Dounia, additional, Bouhour, Damien, additional, Bouiller, Kévin, additional, Bouillet, Laurence, additional, Bouisse, Camile, additional, Boureau, Anne-Sophie, additional, Bourke, John, additional, Bouscambert, Maude, additional, Bousquet, Aurore, additional, Bouziotis, Jason, additional, Boxma, Bianca, additional, Boyer-Besseyre, Marielle, additional, Boylan, Maria, additional, Bozza, Fernando Augusto, additional, Brack, Matthew, additional, Braconnier, Axelle, additional, Braga, Cynthia, additional, Brandenburger, Timo, additional, Brás Monteiro, Filipa, additional, Brazzi, Luca, additional, Breen, Dorothy, additional, Breen, Patrick, additional, Brett, Stephen, additional, Brickell, Kathy, additional, Broadley, Tessa, additional, Browne, Alex, additional, Browne, Shaunagh, additional, Brozzi, Nicolas, additional, Brusse-Keizer, Marjolein, additional, Buchtele, Nina, additional, Buesaquillo, Christian, additional, Bugaeva, Polina, additional, Buisson, Marielle, additional, Burhan, Erlina, additional, Burrell, Aidan, additional, Bustos, Ingrid G., additional, Butnaru, Denis, additional, Cabie, André, additional, Cabral, Susana, additional, Caceres, Eder, additional, Cadoz, Cyril, additional, Callahan, Mia, additional, Calligy, Kate, additional, Calvache, Jose Andres, additional, Cam, João, additional, Campana, Valentine, additional, Campbell, Paul, additional, Campisi, Josie, additional, Canepa, Cecilia, additional, Cantero, Mireia, additional, Caraux-Paz, Pauline, additional, Cárcel, Sheila, additional, Cardellino, Chiara Simona, additional, Cardoso, Filipa, additional, Cardoso, Filipe, additional, Cardoso, Nelson, additional, Cardoso, Sofia, additional, Carelli, Simone, additional, Carlier, Nicolas, additional, Carmoi, Thierry, additional, Carney, Gayle, additional, Carpenter, Chloe, additional, Carqueja, Inês, additional, Carret, Marie-Christine, additional, Carrier, François Martin, additional, Carroll, Ida, additional, Carson, Gail, additional, Carton, Ed, additional, Casanova, Maire-Laure, additional, Cascão, Mariana, additional, Casey, Siobhan, additional, Casimiro, José, additional, Cassandra, Bailey, additional, Castañeda, Silvia, additional, Castanheira, Nidyanara, additional, Castor-Alexandre, Guylaine, additional, Castrillón, Henry, additional, Castro, Ivo, additional, Catarino, Ana, additional, Catherine, François-Xavier, additional, Cattaneo, Paolo, additional, Cavalin, Roberta, additional, Cavalli, Giulio Giovanni, additional, Cavayas, Alexandros, additional, Ceccato, Adrian, additional, Cervantes-Gonzalez, Minerva, additional, Chair, Anissa, additional, Chakveatze, Catherine, additional, Chan, Adrienne, additional, Chand, Meera, additional, Chantalat Auger, Christelle, additional, Chapplain, Jean-Marc, additional, Chas, Julie, additional, Chaudary, Mobin, additional, Chávez Iñiguez, Jonathan Samuel, additional, Chen, Anjellica, additional, Chen, Yih-Sharng, additional, Cheng, Matthew Pellan, additional, Cheret, Antoine, additional, Chiarabini, Thibault, additional, Chica, Julian, additional, Chidambaram, Suresh Kumar, additional, Chin-Tho, Leong, additional, Chirouze, Catherine, additional, Chiumello, Davide, additional, Cho, Hwa Jin, additional, Cho, Sung-Min, additional, Cholley, Bernard, additional, Chopin, Marie-Charlotte, additional, Chow, Ting Soo, additional, Chow, Yock Ping, additional, Chua, Hiu Jian, additional, Chua, Jonathan, additional, Cidade, Jose Pedro, additional, Cisneros Herreros, José Miguel, additional, Citarella, Barbara Wanjiru, additional, Ciullo, Anna, additional, Clarke, Emma, additional, Clarke, Jennifer, additional, Claure Del Granado, Rolando, additional, Clohisey, Sara, additional, Cobb, J. Perren, additional, Coca, Necsoi, additional, Codan, Cassidy, additional, Cody, Caitriona, additional, Coelho, Alexandra, additional, Coles, Megan, additional, Colin, Gwenhaël, additional, Collins, Michael, additional, Colombo, Sebastiano Maria, additional, Combs, Pamela, additional, Connolly, Jennifer, additional, Connor, Marie, additional, Conrad, Anne, additional, Contreras, Sofía, additional, Conway, Elaine, additional, Cooke, Graham S., additional, Copland, Mary, additional, Cordel, Hugues, additional, Corley, Amanda, additional, Cormican, Sarah, additional, Cornelis, Sabine, additional, Cornet, Alexander Daniel, additional, Corpuz, Arianne Joy, additional, Cortegiani, Andrea, additional, Corvaisier, Grégory, additional, Costigan, Emma, additional, Couffignal, Camille, additional, Couffin-Cadiergues, Sandrine, additional, Courtois, Roxane, additional, Cousse, Stéphanie, additional, Cregan, Rachel, additional, Crepy D'Orleans, Charles, additional, Croonen, Sabine, additional, Crowl, Gloria, additional, Crump, Jonathan, additional, Cruz, Claudina, additional, Cruz Berm, Juan Luis, additional, Cruz Rojo, Jaime, additional, Csete, Marc, additional, Cucino, Alberto, additional, Cullen, Ailbhe, additional, Cullen, Caroline, additional, Cummings, Matthew, additional, Curley, Gerard, additional, Curlier, Elodie, additional, Curran, Colleen, additional, Custodio, Paula, additional, da Silva Filipe, Ana, additional, Da Silveira, Charlene, additional, Dabaliz, Al-Awwab, additional, Dagens, Andrew, additional, Dahly, Darren, additional, Dalton, Heidi, additional, Dalton, Jo, additional, Daly, Seamus, additional, D'Amico, Federico, additional, Daneman, Nick, additional, Daniel, Corinne, additional, Dankwa, Emmanuelle A, additional, Dantas, Jorge, additional, D’Aragon, Frédérick, additional, de Boer, Mark, additional, de Loughry, Gillian, additional, de Mendoza, Diego, additional, De Montmollin, Etienne, additional, de Oliveira França, Rafael Freitas, additional, de Pinho Oliveira, Ana Isabel, additional, De Rosa, Rosanna, additional, de Silva, Thushan, additional, de Vries, Peter, additional, Deacon, Jillian, additional, Dean, David, additional, Debard, Alexa, additional, DeBenedictis, Bianca, additional, Debray, Marie-Pierre, additional, DeCastro, Nathalie, additional, Dechert, William, additional, Deconninck, Lauren, additional, Decours, Romain, additional, Defous, Eve, additional, Delacroix, Isabelle, additional, Delaveuve, Eric, additional, Delavigne, Karen, additional, Delfos, Nathalie M., additional, Deligiannis, Ionna, additional, Dell'Amore, Andrea, additional, Delmas, Christelle, additional, Delobel, Pierre, additional, Delsing, Corine, additional, Demonchy, Elisa, additional, Denis, Emmanuelle, additional, Deplanque, Dominique, additional, Depuydt, Pieter, additional, Desai, Mehul, additional, Descamps, Diane, additional, Desvallée, Mathilde, additional, Dewayanti, Santi, additional, Diallo, Alpha, additional, Diamantis, Sylvain, additional, Dias, André, additional, Diaz, Priscila, additional, Diaz, Rodrigo, additional, Diaz Diaz, Juan Jose, additional, Didier, Kévin, additional, Diehl, Jean-Luc, additional, Dieperink, Wim, additional, Dimet, Jérôme, additional, Dinot, Vincent, additional, Diop, Fara, additional, Diouf, Alphonsine, additional, Dishon, Yael, additional, Dixit, Devika, additional, Djossou, Félix, additional, Docherty, Annemarie B., additional, Doherty, Helen, additional, Dondorp, Arjen M, additional, Dong, Andy, additional, Donnelly, Christl A., additional, Donnelly, Maria, additional, Donohue, Chloe, additional, Donohue, Sean, additional, Donohue, Yoann, additional, Doran, Ciara, additional, Doran, Peter, additional, Dorival, Céline, additional, D'Ortenzio, Eric, additional, Douglas, James Joshua, additional, Douma, Renee, additional, Dournon, Nathalie, additional, Downer, Triona, additional, Downey, Joanne, additional, Downing, Mark, additional, Drake, Tom, additional, Driscoll, Aoife, additional, Dryden, Murray, additional, Duarte Fonseca, Claudio, additional, Dubee, Vincent, additional, Dubos, François, additional, Ducancelle, Alexandre, additional, Duculan, Toni, additional, Dudman, Susanne, additional, Duggal, Abhijit, additional, Dunand, Paul, additional, Dunning, Jake, additional, Duplaix, Mathilde, additional, Durante-Mangoni, Emanuele, additional, Durham III, Lucian, additional, Dussol, Bertrand, additional, Duthoit, Juliette, additional, Duval, Xavier, additional, Dyrhol-Riise, Anne Margarita, additional, Ean, Sim Choon, additional, Echeverria-Villalobos, Marco, additional, Egan, Siobhan, additional, Eira, Carla, additional, El Sanharawi, Mohammed, additional, Elapavaluru, Subbarao, additional, Elharrar, Brigitte, additional, Ellerbroek, Jacobien, additional, Eloy, Philippine, additional, Elshazly, Tarek, additional, Elyazar, Iqbal, additional, Enderle, Isabelle, additional, Endo, Tomoyuki, additional, Eng, Chan Chee, additional, Engelmann, Ilka, additional, Enouf, Vincent, additional, Epaulard, Olivier, additional, Escher, Martina, additional, Esperatti, Mariano, additional, Esperou, Hélène, additional, Esposito-Farese, Marina, additional, Estevão, João, additional, Etienne, Manuel, additional, Ettalhaoui, Nadia, additional, Everding, Anna Greti, additional, Evers, Mirjam, additional, Fabre, Isabelle, additional, Fabre, Marc, additional, Faheem, Amna, additional, Fahy, Arabella, additional, Fairfield, Cameron J., additional, Fakar, Zul, additional, Faria, Pedro, additional, Farooq, Ahmed, additional, Farrar, Jeremy J., additional, Farshait, Nataly, additional, Fateena, Hanan, additional, Fatoni, Arie Zainul, additional, Faure, Karine, additional, Favory, Raphaël, additional, Fayed, Mohamed, additional, Feely, Niamh, additional, Feeney, Laura, additional, Fernandes, Jorge, additional, Fernandes, Marília, additional, Fernandes, Susana, additional, Ferrand, François-Xavier, additional, Ferrand Devouge, Eglantine, additional, Ferrão, Joana, additional, Ferraz, Mário, additional, Ferreira, Benigno, additional, Ferreira, Sílvia, additional, Ferrer-Roca, Ricard, additional, Ferriere, Nicolas, additional, Ficko, Céline, additional, Figueiredo-Mello, Claudia, additional, Fiorda, Juan, additional, Flament, Thomas, additional, Flateau, Clara, additional, Fletcher, Tom, additional, Florio, Letizia Lucia, additional, Flynn, Brigid, additional, Flynn, Deirdre, additional, Foley, Claire, additional, Foley, Jean, additional, Fomin, Victor, additional, Fonseca, Tatiana, additional, Fontela, Patricia, additional, Forsyth, Simon, additional, Foster, Denise, additional, Foti, Giuseppe, additional, Fourn, Erwan, additional, Fowler, Robert A., additional, Fraher, Dr Marianne, additional, Franch-Llasat, Diego, additional, Fraser, Christophe, additional, Fraser, John F., additional, Freire, Marcela Vieira, additional, Freitas Ribeiro, Ana, additional, Friedrich, Caren, additional, Fritz, Ricardo, additional, Fry, Stéphanie, additional, Fuentes, Nora, additional, Fukuda, Masahiro, additional, Gaborieau, Valérie, additional, Gaci, Rostane, additional, Gagliardi, Massimo, additional, Gagnard, Jean-Charles, additional, Gagné, Nathalie, additional, Gagneux-Brunon, Amandine, additional, Gaião, Sérgio, additional, Gail Skeie, Linda, additional, Gallagher, Phil, additional, Gallego Curto, Elena, additional, Gamble, Carrol, additional, Gani, Yasmin, additional, Garan, Arthur, additional, Garcia, Rebekha, additional, García Barrio, Noelia, additional, Garcia-Diaz, Julia, additional, Garcia-Gallo, Esteban, additional, Garimella, Navya, additional, Garot, Denis, additional, Garrait, Valérie, additional, Gauli, Basanta, additional, Gault, Nathalie, additional, Gavin, Aisling, additional, Gavrylov, Anatoliy, additional, Gaymard, Alexandre, additional, Gebauer, Johannes, additional, Geraud, Eva, additional, Gerbaud Morlaes, Louis, additional, Germano, Nuno, additional, ghisulal, praveen kumar, additional, Ghosn, Jade, additional, Giani, Marco, additional, Giaquinto, Carlo, additional, Gibson, Jess, additional, Gigante, Tristan, additional, Gilg, Morgane, additional, Gilroy, Elaine, additional, Giordano, Guillermo, additional, Girvan, Michelle, additional, Gissot, Valérie, additional, Gitahi, Judy, additional, Giwangkancana, Gezy, additional, Glikman, Daniel, additional, Glybochko, Petr, additional, Gnall, Eric, additional, Goco, Geraldine, additional, Goehringer, François, additional, Goepel, Siri, additional, Goffard, Jean-Christophe, additional, Goh, Jin Yi, additional, Golob, Jonathan, additional, Gomes, Rui, additional, Gomez, Kyle, additional, Gómez-Junyent, Joan, additional, Gominet, Marie, additional, Gonzalez, Alicia, additional, Gordon, Patricia, additional, Gordon, Anthony, additional, Gorenne, Isabelle, additional, Goubert, Laure, additional, Goujard, Cécile, additional, Goulenok, Tiphaine, additional, Grable, Margarite, additional, Graf, Jeronimo, additional, Grandin, Edward Wilson, additional, Granier, Pascal, additional, Grasselli, Giacomo, additional, Grazioli, Lorenzo, additional, Green, Christopher A., additional, Greene, Courtney, additional, Greenhalf, William, additional, Greffe, Segolène, additional, Grieco, Domenico Luca, additional, Griffee, Matthew, additional, Griffiths, Fiona, additional, Grigoras, Ioana, additional, Groenendijk, Albert, additional, Grosse Lordemann, Anja, additional, Gruner, Heidi, additional, Gu, Yusing, additional, Guarracino, Fabio, additional, Guedj, Jérémie, additional, Guego, Martin, additional, Guellec, Dewi, additional, Guerguerian, Anne-Marie, additional, Guerreiro, Daniela, additional, Guery, Romain, additional, Guillaumot, Anne, additional, Guilleminault, Laurent, additional, Guimarães de Castro, Maisa, additional, Guimard, Thomas, additional, Haalboom, Marieke, additional, Haber, Daniel, additional, Habraken, Hannah, additional, Hachemi, Ali, additional, Hadri, Nadir, additional, Haidash, Olena, additional, Haider, Saeeda, additional, Haidri, Fakhir, additional, Hakak, Sheeba, additional, Hall, Adam, additional, Hall, Matthew, additional, Halpin, Sophie, additional, Hamer, Ansley, additional, Hamers, Raph, additional, Hamidfar, Rebecca, additional, Hammond, Terese, additional, Han, Lim Yuen, additional, Haniffa, Rashan, additional, Hao, Kok Wei, additional, Hardwick, Hayley, additional, Harrison, Ewen M., additional, Harrison, Janet, additional, Harrison, Samuel Bernard Ekow, additional, Hartman, Alan, additional, Hashmi, Junaid, additional, Hashmi, Madiha, additional, Hayat, Muhammad, additional, Hayes, Ailbhe, additional, Hays, Leanne, additional, Heerman, Jan, additional, Heggelund, Lars, additional, Hendry, Ross, additional, Hennessy, Martina, additional, Henriquez, Aquiles, additional, Hentzien, Maxime, additional, Herekar, Fivzia, additional, Hernandez-Montfort, Jaime, additional, Herr, Daniel, additional, Hershey, Andrew, additional, Hesstvedt, Liv, additional, Hidayah, Astarini, additional, Higgins, Dawn, additional, Higgins, Eibhilin, additional, HigginsOKeeffe, Grainne, additional, Hinchion, Rita, additional, Hinton, Samuel, additional, Hiraiwa, Hiroaki, additional, Hitoto, Hikombo, additional, Ho, Antonia, additional, Ho, Yi Bin, additional, Hoctin, Alexandre, additional, Hoffmann, Isabelle, additional, Hoh, Wei Han, additional, Hoiting, Oscar, additional, Holt, Rebecca, additional, Holter, Jan Cato, additional, Horby, Peter, additional, Horcajada, Juan Pablo, additional, Hoshino, Koji, additional, Hoshino, Kota, additional, Houas, Ikram, additional, Hough, Catherine L., additional, Houltham, Stuart, additional, Hsu, Jimmy Ming-Yang, additional, Hulot, Jean-Sébastien, additional, Hussain, Iqbal, additional, Ijaz, Samreen, additional, Illes, Hajnal-Gabriela, additional, Imbert, Patrick, additional, Imran, Mohammad, additional, Imran Sikander, Rana, additional, Inácio, Hugo, additional, Infante Dominguez, Carmen, additional, Ing, Yun Sii, additional, Iosifidis, Elias, additional, Ippolito, Mariachiara, additional, Isgett, Sarah, additional, Ishani, Palliya Guruge Pramodya Ishani, additional, Isidoro, Tiago, additional, Ismail, Nadiah, additional, Isnard, Margaux, additional, Itai, Junji, additional, Ito, Asami, additional, Ivulich, Daniel, additional, Jaafar, Danielle, additional, Jaafoura, Salma, additional, Jabot, Julien, additional, Jackson, Clare, additional, Jamieson, Nina, additional, Jaquet, Pierre, additional, Jassat, Waasila, additional, Jaud-Fischer, Coline, additional, Jaureguiberry, Stéphane, additional, Javidfar, Jeffrey, additional, Jawad, Issrah, additional, Jaworsky, Denise, additional, Jayakumar, Devachandran, additional, Jego, Florence, additional, Jelani, Anilawati Mat, additional, Jenum, Synne, additional, Jimbo-Sotomayor, Ruth, additional, Job, van der Palen, additional, Joe, Ong Yiaw, additional, Jorge García, Ruth N., additional, Joseph, Cédric, additional, Joseph, Mark, additional, Joshi, Swosti, additional, Jourdain, Mercé, additional, Jouvet, Philippe, additional, June, Jennifer, additional, Jung, Anna, additional, Jung, Hanna, additional, Juzar, Dafsah, additional, Kafif, Ouifiya, additional, Kaguelidou, Florentia, additional, Kaisbain, Neerusha, additional, Kaleesvran, Thavamany, additional, Kali, Sabina, additional, Kalicinska, Alina, additional, Kalomoiri, Smaragdi, additional, Kamal, Saima, additional, Kamaluddin, Muhammad Aisar Ayadi, additional, Kamaruddin, Zul Amali Che, additional, Kamarudin, Nadiah, additional, Kandamby, Darshana Hewa, additional, Kandel, Chris, additional, Kang, Kong Yeow, additional, Kant, Ravi, additional, Kanwal, Darakhshan, additional, Kanyawati, Dyah, additional, Karki, Bipin, additional, Karpayah, Pratap, additional, Karsies, Todd, additional, Kartsonaki, Christiana, additional, Kasugai, Daisuke, additional, Kataria, Anant, additional, Katz, Kevin, additional, Kaur, Aasmine, additional, Kaur Johal, Simreen, additional, Kawasaki, Tatsuya, additional, Kay, Christy, additional, Keane, Hannah, additional, Keating, Seán, additional, Kellam, Paul, additional, Kelly, Andrea, additional, Kelly, Aoife, additional, Kelly, Claire, additional, Kelly, Niamh, additional, Kelly, Sadie, additional, Kelly, Yvelynne, additional, Kelsey, Maeve, additional, Kennedy, Ryan, additional, Kennon, Kalynn, additional, Kernan, Maeve, additional, Kerroumi, Younes, additional, Keshav, Sharma, additional, Kestelyn, Evelyne, additional, Khalid, Imrana, additional, Khalid, Osama, additional, Khalil, Antoine, additional, Khan, Coralie, additional, Khan, Irfan, additional, Khanal, Sushil, additional, Kho, Michelle E, additional, Khoo, Denisa, additional, Khoo, Ryan, additional, Khoo, Saye, additional, Khoso, Nasir, additional, Kiat, Khor How, additional, Kida, Yuri, additional, Kiiza, Peter, additional, Kildal, Anders Benjamin, additional, Kim, Jae Burm, additional, Kimmoun, Antoine, additional, Kindgen-Milles, Detlef, additional, King, Alexander, additional, Kitamura, Nobuya, additional, Klenerman, Paul, additional, Klont, Rob, additional, Kloumann Bekken, Gry, additional, Knight, Stephen, additional, Kobbe, Robin, additional, Kodippily, Chamira, additional, Kohns Vasconcelos, Malte, additional, Koirala, Sabin, additional, Komatsu, Mamoru, additional, Korten, Volkan, additional, Kosgei, Caroline, additional, Kpangon, Arsène, additional, Krawczyk, Karolina, additional, Krishnan, Sudhir, additional, Krishnan, Vinothini, additional, Kruglova, Oksana, additional, Kumar, Ashok, additional, Kumar, Deepali, additional, Kumar, Ganesh, additional, Kumar, Mukesh, additional, Kumar Vecham, Pavan, additional, Kuriakose, Dinesh, additional, Kurtzman, Ethan, additional, Kusumastuti, Neurinda Permata, additional, Kutsogiannis, Demetrios, additional, Kutsyna, Galyna, additional, Kyriakoulis, Konstantinos, additional, Lachatre, Marie, additional, Lacoste, Marie, additional, Laffey, John G., additional, Lagrange, Marie, additional, Laine, Fabrice, additional, Lairez, Olivier, additional, Lakhey, Sanjay, additional, Lalueza, Antonio, additional, Lambert, Marc, additional, Lamontagne, François, additional, Langelot-Richard, Marie, additional, Langlois, Vincent, additional, Lantang, Eka Yudha, additional, Lanza, Marina, additional, Laouénan, Cédric, additional, Laribi, Samira, additional, Lariviere, Delphine, additional, Lasry, Stéphane, additional, Latif, Naveed, additional, Launay, Odile, additional, Laureillard, Didier, additional, Lavie-Badie, Yoan, additional, Law, Andy, additional, Lawrence, Cassie, additional, Lawrence, Teresa, additional, Le, Minh, additional, Le Bihan, Clément, additional, Le Bris, Cyril, additional, Le Falher, Georges, additional, Le Fevre, Lucie, additional, Le Hingrat, Quentin, additional, Le Maréchal, Marion, additional, Le Mestre, Soizic, additional, Le Moal, Gwenaël, additional, Le Moing, Vincent, additional, Le Nagard, Hervé, additional, Le Turnier, Paul, additional, Leal, Ema, additional, Leal Santos, Marta, additional, Lee, Biing Horng, additional, Lee, Heng Gee, additional, Lee, James, additional, Lee, Su Hwan, additional, Lee, Todd C., additional, Lee, Yi Lin, additional, Leeming, Gary, additional, Lefebvre, Bénédicte, additional, Lefebvre, Laurent, additional, Lefevre, Benjamin, additional, LeGac, Sylvie, additional, Lelievre, Jean-Daniel, additional, Lellouche, François, additional, Lemaignen, Adrien, additional, Lemee, Véronique, additional, Lemeur, Anthony, additional, Lemmink, Gretchen, additional, Lene, Ha Sha, additional, Lennon, Jenny, additional, León, Rafael, additional, Leone, Marc, additional, Leone, Michela, additional, Lepiller, Quentin, additional, Lescure, François-Xavier, additional, Lesens, Olivier, additional, Lesouhaitier, Mathieu, additional, Lester-Grant, Amy, additional, Levy, Bruno, additional, Levy, Yves, additional, Levy-Marchal, Claire, additional, Lewandowska, Katarzyna, additional, L'Her, Erwan, additional, Li Bassi, Gianluigi, additional, Liang, Janet, additional, Liaquat, Ali, additional, Liegeon, Geoffrey, additional, Lim, Kah Chuan, additional, Lim, Wei Shen, additional, Lima, Chantre, additional, Lina, Bruno, additional, Lina, Lim, additional, Lind, Andreas, additional, Lingas, Guillaume, additional, Lion-Daolio, Sylvie, additional, Lissauer, Samantha, additional, Liu, Keibun, additional, Livrozet, Marine, additional, Lizotte, Patricia, additional, Loforte, Antonio, additional, Lolong, Navy, additional, Loon, Leong Chee, additional, Lopes, Diogo, additional, Lopez-Colon, Dalia, additional, Loschner, Anthony L., additional, Loubet, Paul, additional, Loufti, Bouchra, additional, Louis, Guillame, additional, Lourenco, Silvia, additional, Lovelace-Macon, Lara, additional, Low, Lee Lee, additional, Lowik, Marije, additional, Loy, Jia Shyi, additional, Lucet, Jean Christophe, additional, Lumbreras Bermejo, Carlos, additional, Luna, Carlos M., additional, Lungu, Olguta, additional, Luong, Liem, additional, Luque, Nestor, additional, Luton, Dominique, additional, Lwin, Nilar, additional, Lyons, Ruth, additional, Maasikas, Olavi, additional, Mabiala, Oryane, additional, MacDonald, Samual, additional, MacDonald, Sarah, additional, Machado, Moïse, additional, Macheda, Gabriel, additional, Macias Sanchez, Juan, additional, Madhok, Jai, additional, Maestro de la Calle, Guillermo, additional, Mahieu, Rafael, additional, Mahy, Sophie, additional, Maia, Ana Raquel, additional, Maier, Lars S., additional, Maillet, Mylène, additional, Maitre, Thomas, additional, Malfertheiner, Maximilian, additional, Malik, Nadia, additional, Mallon, Paddy, additional, Maltez, Fernando, additional, Malvy, Denis, additional, Manda, Victoria, additional, Mandei, Jose M., additional, Mandelbrot, Laurent, additional, Manetta, Frank, additional, Mangal, Kishore, additional, Mankikian, Julie, additional, Manning, Edmund, additional, Manuel, Aldric, additional, Maria Sant`Ana Malaque, Ceila, additional, Marino, Daniel, additional, Marino, Flávio, additional, Markowicz, Samuel, additional, Maroun Eid, Charbel, additional, Marques, Ana, additional, Marquis, Catherine, additional, Marsh, Brian, additional, Marsh, Laura, additional, Marshal, Megan, additional, Marshall, John, additional, Martelli, Celina Turchi, additional, Martin, Dori-Ann, additional, Martin, Emily, additional, Martin-Blondel, Guillaume, additional, Martinelli, Alessandra, additional, Martin-Loeches, Ignacio, additional, Martinot, Martin, additional, Martin-Quiros, Alejandro, additional, Martins, Ana, additional, Martins, João, additional, Martins, Nuno, additional, Martins Rego, Caroline, additional, Martucci, Gennaro, additional, Martynenko, Olga, additional, Marwali, Eva Miranda, additional, Marzukie, Marsilla, additional, Masa Jimenez, Juan Fernado, additional, Maslove, David, additional, Mason, Phillip, additional, Mason, Sabina, additional, Masood, Sobia, additional, Mat Nor, Basri, additional, Matan, Moshe, additional, Mateus Fernandes, Henrique, additional, Mathew, Meghena, additional, Mathieu, Daniel, additional, Mattei, Mathieu, additional, Matulevics, Romans, additional, Maulin, Laurence, additional, Maxwell, Michael, additional, Maynar, Javier, additional, Mazzoni, Thierry, additional, Mc Sweeney, Lisa, additional, McAndrew, Lorraine, additional, McArthur, Colin, additional, McCarthy, Aine, additional, McCarthy, Anne, additional, McCloskey, Colin, additional, McConnochie, Rachael, additional, McDermott, Sherry, additional, McDonald, Sarah E., additional, McElroy, Aine, additional, McElwee, Samuel, additional, McEneany, Victoria, additional, McEvoy, Natalie, additional, McGeer, Allison, additional, McKay, Chris, additional, McKeown, Johnny, additional, McLean, Kenneth A., additional, McNally, Paul, additional, McNicholas, Bairbre, additional, McPartlan, Elaine, additional, Meaney, Edel, additional, Mear-Passard, Cécile, additional, Mechlin, Maggie, additional, Meher, Maqsood, additional, Mehkri, Omar, additional, Mele, Ferruccio, additional, Melo, Luis, additional, Memon, Kashif, additional, Mendes, Joao Joao, additional, Menkiti, Ogechukwu, additional, Menon, Kusum, additional, Mentré, France, additional, Mentzer, Alexander J., additional, Mercier, Emmanuelle, additional, Mercier, Noémie, additional, Merckx, Antoine, additional, Mergeay-Fabre, Mayka, additional, Mergler, Blake, additional, Merson, Laura, additional, Mesquita, António, additional, Metwally, Osama, additional, Meybeck, Agnès, additional, Meyer, Dan, additional, Meynert, Alison M., additional, Meysonnier, Vanina, additional, Meziane, Amina, additional, Mezidi, Mehdi, additional, Michelagnoli, Giuliano, additional, Michelanglei, Céline, additional, Michelet, Isabelle, additional, Mihelis, Efstathia, additional, Mihnovit, Vladislav, additional, Miranda-Maldonado, Hugo, additional, Misnan, Nor Arisah, additional, Mohamed, Nik Nur Eliza, additional, Mohamed, Tahira Jamal, additional, Moin, Asma, additional, Molina, David, additional, Molinos, Elena, additional, Molloy, Brenda, additional, Mone, Mary, additional, Monteiro, Agostinho, additional, Montes, Claudia, additional, Montrucchio, Giorgia, additional, Moore, Sarah, additional, Moore, Shona C., additional, Morales Cely, Lina, additional, Moro, Lucia, additional, Morocho Tutillo, Diego Rolando, additional, Morton, Ben, additional, Motherway, Catherine, additional, Motos, Ana, additional, Mouquet, Hugo, additional, Mouton Perrot, Clara, additional, Moyet, Julien, additional, Mudara, Caroline, additional, Mufti, Aisha Kalsoom, additional, Muh, Ng Yong, additional, Muhamad, Dzawani, additional, Mullaert, Jimmy, additional, Muller, Fredrik, additional, Müller, Karl Erik, additional, Munblit, Daniel, additional, Muneeb, Syed, additional, Munir, Nadeem, additional, Munshi, Laveena, additional, Murphy, Aisling, additional, Murphy, Lorna, additional, Murris, Marlène, additional, Murthy, Srinivas, additional, Musaab, Himed, additional, Muyandy, Gugapriyaa, additional, Myrodia, Dimitra Melia, additional, N, Namra, additional, Nagpal, Dave, additional, Nagrebetsky, Alex, additional, Narasimhan, Mangala, additional, Narayanan, Nageswaran, additional, Nasim Khan, Rashid, additional, Nazerali-Maitland, Alasdair, additional, Neant, Nadège, additional, Neb, Holger, additional, Nekliudov, Nikita A, additional, Nelwan, Erni, additional, Neto, Raul, additional, Neumann, Emily, additional, Neves, Bernardo, additional, Ng, Pauline Yeung, additional, Nghi, Anthony, additional, Nguyen, Duc, additional, Ni Choileain, Orna, additional, Ni Leathlobhair, Niamh, additional, Nichol, Alistair, additional, Nitayavardhana, Prompak, additional, Nonas, Stephanie, additional, Noordin, Nurul Amani Mohd, additional, Noret, Marion, additional, Norharizam, Nurul Faten Izzati, additional, Norman, Lisa, additional, Notari, Alessandra, additional, Noursadeghi, Mahdad, additional, Nowicka, Karolina, additional, Nowinski, Adam, additional, Nseir, Saad, additional, Nunez, Jose I, additional, Nurnaningsih, Nurnaningsih, additional, Nyamankolly, Elsa, additional, O Brien, Fionnuala, additional, O'Callaghan, Annmarie, additional, Occhipinti, Giovanna, additional, OConnor, Derbrenn, additional, O'Donnell, Max, additional, Ogston, Tawnya, additional, Ogura, Takayuki, additional, Oh, Tak-Hyuk, additional, O'Halloran, Sophie, additional, O'Hearn, Katie, additional, Ohshimo, Shinichiro, additional, Oldakowska, Agnieszka, additional, Oliveira, João, additional, Oliveira, Larissa, additional, Olliaro, Piero L., additional, O'Neil, Conar, additional, Ong, David S.Y., additional, Ong, Jee Yan, additional, Oosthuyzen, Wilna, additional, Opavsky, Anne, additional, Openshaw, Peter, additional, Orakzai, Saijad, additional, Orozco-Chamorro, Claudia Milena, additional, Orquera, Andrés, additional, Ortoleva, Jamel, additional, Osatnik, Javier, additional, O'Shea, Linda, additional, O'Sullivan, Miriam, additional, Othman, Siti Zubaidah, additional, Ouamara, Nadia, additional, Ouissa, Rachida, additional, Owyang, Clark, additional, Oziol, Eric, additional, Pabasara, H M Upulee, additional, Pagadoy, Maïder, additional, Pages, Justine, additional, Palacios, Amanda, additional, Palacios, Mario, additional, Palmarini, Massimo, additional, Panarello, Giovanna, additional, Panda, Prasan Kumar, additional, Paneru, Hem, additional, Pang, Lai Hui, additional, Panigada, Mauro, additional, Pansu, Nathalie, additional, Papadopoulos, Aurélie, additional, Parke, Rachael, additional, Parker, Melissa, additional, Parra, Briseida, additional, Parrini, Vieri, additional, Pasha, Taha, additional, Pasquier, Jérémie, additional, Pastene, Bruno, additional, Patauner, Fabian, additional, Patel, Junaid, additional, Pathmanathan, Mohan Dass, additional, Patrão, Luís, additional, Patricio, Patricia, additional, Patrier, Juliette, additional, Patterson, Lisa, additional, Pattnaik, Rajyabardhan, additional, Paul, Christelle, additional, Paul, Mical, additional, Paulos, Jorge, additional, Paxton, William A., additional, Payen, Jean-François, additional, Peariasamy, Kalaiarasu, additional, Pedrera Jiménez, Miguel, additional, Peek, Giles J., additional, Peelman, Florent, additional, Peiffer-Smadja, Nathan, additional, Peigne, Vincent, additional, Pejkovska, Mare, additional, Pelosi, Paolo, additional, Peltan, Ithan D., additional, Pereira, Rui, additional, Perez, Daniel, additional, Periel, Luis, additional, Perpoint, Thomas, additional, Pesenti, Antonio, additional, Pestre, Vincent, additional, Petrou, Lenka, additional, Petrov-Sanchez, Ventzislava, additional, Pettersen, Frank Olav, additional, Peytavin, Gilles, additional, Pharand, Scott, additional, Piagnerelli, Michael, additional, Picard, Walter, additional, Picone, Olivier, additional, Piero, Maria de, additional, Pierobon, Carola, additional, Piersma, Djura, additional, Pimentel, Carlos, additional, Pinto, Raquel, additional, Pires, Catarina, additional, Pironneau, Isabelle, additional, Piroth, Lionel, additional, Pius, Riinu, additional, Piva, Simone, additional, Plantier, Laurent, additional, Plotkin, Daniel, additional, Png, Hon Shen, additional, Poissy, Julien, additional, Pokeerbux, Ryadh, additional, Pokorska-Spiewak, Maria, additional, Poli, Sergio, additional, Pollakis, Georgios, additional, Ponscarme, Diane, additional, Popielska, Jolanta, additional, Post, Andra-Maris, additional, Postma, Douwe F., additional, Povoa, Pedro, additional, Póvoas, Diana, additional, Powis, Jeff, additional, Prapa, Sofia, additional, Preau, Sébastien, additional, Prebensen, Christian, additional, Preiser, Jean-Charles, additional, Prinssen, Anton, additional, Pritchard, Mark G., additional, Priyadarshani, Gamage Dona Dilanthi, additional, Proença, Lucia, additional, Pudota, Sravya, additional, Puéchal, Oriane, additional, Pujo Semedi, Bambang, additional, Pulicken, Mathew, additional, Puntoni, Matteo, additional, Purcell, Gregory, additional, Quesada, Luisa, additional, Quinones-Cardona, Vilmaris, additional, Quirós González, Víctor, additional, Quist-Paulsen, Else, additional, Quraishi, Mohammed, additional, Rabaa, Maia, additional, Rabaud, Christian, additional, Rabindrarajan, Ebenezer, additional, Rafael, Aldo, additional, Rafiq, Marie, additional, Ragazzo, Gabrielle, additional, Rahman, Ahmad Kashfi Haji Ab, additional, Rahman, Rozanah Abd, additional, Rahutullah, Arsalan, additional, Rainieri, Fernando, additional, Rajahram, Giri Shan, additional, Rajapakse, Nipunie, additional, Ralib, Azrina, additional, Ramakrishnan, Nagarajan, additional, Ramanathan, Kollengode, additional, Ramli, Ahmad Afiq, additional, Rammaert, Blandine, additional, Ramos, Grazielle Viana, additional, Rana, Asim, additional, Rangappa, Rajavardhan, additional, Ranjan, Ritika, additional, Rapp, Christophe, additional, Rashan, Aasiyah, additional, Rashan, Thalha, additional, Rasheed, Ghulam, additional, Rasmin, Menaldi, additional, Rätsep, Indrek, additional, Rau, Cornelius, additional, Ravi, Tharmini, additional, Raza, Ali, additional, Real, Andre, additional, Rebaudet, Stanislas, additional, Redl, Sarah, additional, Reeve, Brenda, additional, Rehan, Ali, additional, Rehman, Attaur, additional, Reid, Liadain, additional, Reikvam, Dag Henrik, additional, Reis, Renato, additional, Rello, Jordi, additional, Remppis, Jonathan, additional, Remy, Martine, additional, Ren, Hongru, additional, Renk, Hanna, additional, Resende, Liliana, additional, Resseguier, Anne-Sophie, additional, Revest, Matthieu, additional, Rewa, Oleksa, additional, Reyes, Luis Felipe, additional, Reyes, Tiago, additional, Ribeiro, Maria Ines, additional, Richardson, David, additional, Richardson, Denise, additional, Richier, Laurent, additional, Ridzuan, Siti Nurul Atikah Ahmad, additional, Riera, Jordi, additional, Rios, Ana L, additional, Rishu, Asgar, additional, Rispal, Patrick, additional, Risso, Karine, additional, Rivera Nuñez, Maria Angelica, additional, Rizer, Nicholas, additional, Robb, Doug, additional, Robba, Chiara, additional, Roberto, André, additional, Roberts, Stephanie, additional, Robertson, David L., additional, Robineau, Olivier, additional, Roche-Campo, Ferran, additional, Rodari, Paola, additional, Rodeia, Simão, additional, Rodriguez Abreu, Julia, additional, Roessler, Bernhard, additional, Roger, Claire, additional, Roger, Pierre-Marie, additional, Roilides, Emmanuel, additional, Rojek, Amanda, additional, Romaru, Juliette, additional, Roncon-Albuquerque Jr, Roberto, additional, Roriz, Mélanie, additional, Rosa-Calatrava, Manuel, additional, Rose, Michael, additional, Rosenberger, Dorothea, additional, Rossanese, Andrea, additional, Rossetti, Matteo, additional, Rossignol, Bénédicte, additional, Rossignol, Patrick, additional, Rousset, Stella, additional, Roy, Carine, additional, Roze, Benoît, additional, Rusmawatiningtyas, Desy, additional, Russell, Clark D., additional, Ryan, Maeve, additional, Ryan, Maria, additional, Ryckaert, Steffi, additional, Rygh Holten, Aleksander, additional, Saba, Isabela, additional, Sadaf, Sairah, additional, Sadat, Musharaf, additional, Sahraei, Valla, additional, Saint-Gilles, Maximilien, additional, Sakiyalak, Pranya, additional, Salahuddin, Nawal, additional, Salazar, Leonardo, additional, Saleem, Jodat, additional, Sales, Gabriele, additional, Sallaberry, Stéphane, additional, Salmon Gandonniere, Charlotte, additional, Salvator, Hélène, additional, Sanchez, Olivier, additional, Sánchez Choez, Xavier, additional, Sanchez de Oliveira, Kizy, additional, Sanchez-Miralles, Angel, additional, Sancho-Shimizu, Vanessa, additional, Sandhu, Gyan, additional, Sandhu, Zulfiqar, additional, Sandrine, Pierre-François, additional, Sandulescu, Oana, additional, Santos, Marlene, additional, Sarfo-Mensah, Shirley, additional, Sarmento Banheiro, Bruno, additional, Sarmiento, Iam Claire E., additional, Sarton, Benjamine, additional, Satyapriya, Sree, additional, Satyawati, Rumaisah, additional, Saviciute, Egle, additional, Savio, Raymond, additional, Savvidou, Parthena, additional, Saw, Yen Tsen, additional, Schaffer, Justin, additional, Schermer, Tjard, additional, Scherpereel, Arnaud, additional, Schneider, Marion, additional, Schroll, Stephan, additional, Schwameis, Michael, additional, Schwartz, Gary, additional, Scott, Janet T., additional, Scott-Brown, James, additional, Sedillot, Nicholas, additional, Seitz, Tamara, additional, Selvanayagam, Jaganathan, additional, Selvarajoo, Mageswari, additional, Semaille, Caroline, additional, Semple, Malcolm G., additional, Senian, Rasidah Bt, additional, Senneville, Eric, additional, Sepulveda, Claudia, additional, Sequeira, Filipa, additional, Sequeira, Tânia, additional, Serpa Neto, Ary, additional, Serrano Balazote, Pablo, additional, Shadowitz, Ellen, additional, Shahidan, Syamin Asyraf, additional, Shahnaz Hasan, Mohd, additional, Shamsah, Mohammad, additional, Shankar, Anuraj, additional, Sharjeel, Shaikh, additional, Sharma, Pratima, additional, Shaw, Catherine A., additional, Shaw, Victoria, additional, Shi, Haixia, additional, Shiban, Nisreen, additional, Shiekh, Mohiuddin, additional, Shiga, Takuya, additional, Shime, Nobuaki, additional, Shimizu, Hiroaki, additional, Shimizu, Keiki, additional, Shimizu, Naoki, additional, Shindo, Nahoko, additional, Shrapnel, Sally, additional, Shum, Hoi Ping, additional, Si Mohammed, Nassima, additional, Siang, Ng Yong, additional, Sibiude, Jeanne, additional, Siddiqui, Atif, additional, Sigfrid, Louise, additional, Sillaots, Piret, additional, Silva, Catarina, additional, Silva, Maria Joao, additional, Silva, Rogério, additional, Sim Lim Heng, Benedict, additional, Sin, Wai Ching, additional, Singh, Budha Charan, additional, Singh, Punam, additional, Sitompul, Pompini Agustina, additional, Sivam, Karisha, additional, Skogen, Vegard, additional, Smith, Sue, additional, Smood, Benjamin, additional, Smyth, Coilin, additional, Smyth, Michelle, additional, Snacken, Morgane, additional, So, Dominic, additional, Soh, Tze Vee, additional, Solis, Monserrat, additional, Solomon, Joshua, additional, Solomon, Tom, additional, Somers, Emily, additional, Sommet, Agnès, additional, Song, Myung Jin, additional, Song, Rima, additional, Song, Tae, additional, Song Chia, Jack, additional, Sonntagbauer, Michael, additional, Soom, Azlan Mat, additional, Sotto, Alberto, additional, Soum, Edouard, additional, Sousa, Ana Chora, additional, Sousa, Marta, additional, Sousa Uva, Maria, additional, Souza-Dantas, Vicente, additional, Sperry, Alexandra, additional, Spinuzza, Elisabetta, additional, Sri Darshana, B. P. Sanka Ruwan, additional, Sriskandan, Shiranee, additional, Stabler, Sarah, additional, Staudinger, Thomas, additional, Stecher, Stephanie-Susanne, additional, Steinsvik, Trude, additional, Stienstra, Ymkje, additional, Stiksrud, Birgitte, additional, Stolz, Eva, additional, Stone, Amy, additional, Streinu-Cercel, Adrian, additional, Streinu-Cercel, Anca, additional, Strudwick, Samantha, additional, Stuart, Ami, additional, Stuart, David, additional, Subekti, Decy, additional, Suen, Gabriel, additional, Suen, Jacky Y., additional, Sukumar, Prasanth, additional, Sultana, Asfia, additional, Summers, Charlotte, additional, Supic, Dubravka, additional, Suppiah, Deepashankari, additional, Surovcová, Magdalena, additional, Suwarti, Suwarti, additional, Svistunov, Andrey A, additional, Syahrin, Sarah, additional, Syrigos, Konstantinos, additional, Sztajnbok, Jaques, additional, Szuldrzynski, Konstanty, additional, Tabrizi, Shirin, additional, Taccone, Fabio S., additional, Tagherset, Lysa, additional, Taib, Shahdattul Mawarni, additional, Talarek, Ewa, additional, Taleb, Sara, additional, Talsma, Jelmer, additional, Tampubolon, Maria Lawrensia, additional, Tan, Kim Keat, additional, Tan, Le Van, additional, Tan, Yan Chyi, additional, Tanaka, Clarice, additional, Tanaka, Hiroyuki, additional, Tanaka, Taku, additional, Taniguchi, Hayato, additional, Tanveer, Hussain, additional, Taqdees, Huda, additional, Taqi, Arshad, additional, Tardivon, Coralie, additional, Tattevin, Pierre, additional, Taufik, M Azhari, additional, Tawfik, Hassan, additional, Tedder, Richard S., additional, Tee, Tze Yuan, additional, Teixeira, João, additional, Tejada, Sofia, additional, Tellier, Marie-Capucine, additional, Teoh, Sze Kye, additional, Teotonio, Vanessa, additional, Téoulé, François, additional, Terpstra, Pleun, additional, Terrier, Olivier, additional, Terzi, Nicolas, additional, Tessier-Grenier, Hubert, additional, Tey, Adrian, additional, Thabit, Alif Adlan Mohd, additional, Tham, Zhang Duan, additional, Thangavelu, Suvintheran, additional, Thibault, Vincent, additional, Thiberville, Simon-Djamel, additional, Thill, Benoît, additional, Thirumanickam, Jananee, additional, Thompson, Shaun, additional, Thomson, David, additional, Thomson, Emma C., additional, Thurai, Surain Raaj Thanga, additional, Thuy, Duong Bich, additional, Thwaites, Ryan S., additional, Tierney, Paul, additional, Tieroshyn, Vadim, additional, Timashev, Peter S, additional, Timsit, Jean-François, additional, Tirupakuzhi Vijayaraghavan, Bharath Kumar, additional, Tissot, Noémie, additional, Toh, Jordan Zhien Yang, additional, Toki, Maria, additional, Tolppa, Timo, additional, Tonby, Kristian, additional, Tonnii, Sia Loong, additional, Torres, Antoni, additional, Torres, Margarida, additional, Torres Santos-Olmo, Rosario Maria, additional, Torres-Zevallos, Hernando, additional, Towers, Michael, additional, Trapani, Tony, additional, Traynor, Damien, additional, Treoux, Théo, additional, Trieu, Huynh Trung, additional, Tripathy, Swagata, additional, Tromeur, Cécile, additional, Trontzas, Ioannis, additional, Trouillon, Tiffany, additional, Truong, Jeanne, additional, Tual, Christelle, additional, Tubiana, Sarah, additional, Tuite, Helen, additional, Turmel, Jean-Marie, additional, Turtle, Lance C.W., additional, Tveita, Anders, additional, Twardowski, Pawel, additional, Uchiyama, Makoto, additional, Udayanga, PG Ishara, additional, Udy, Andrew, additional, Ullrich, Roman, additional, Umer, Zubair, additional, Uribe, Alberto, additional, Usman, Asad, additional, Vajdovics, Cristinava, additional, Val-Flores, Luís, additional, Valle, Ana Luiza, additional, Valran, Amélie, additional, Van de Velde, Stijn, additional, van den Berge, Marcel, additional, van der Feltz, Machteld, additional, van der Valk, Paul, additional, Van Der Vekens, Nicky, additional, Van der Voort, Peter, additional, Van Der Werf, Sylvie, additional, van Dyk, Marlice, additional, van Gulik, Laura, additional, Van Hattem, Jarne, additional, van Lelyveld, Steven, additional, van Netten, Carolien, additional, Van Twillert, Gitte, additional, van Veen, Ilonka, additional, Vanel, Noémie, additional, Vanoverschelde, Henk, additional, Varghese, Pooja, additional, Varrone, Michael, additional, Vasudayan, Shoban Raj, additional, Vauchy, Charline, additional, Vaughan, Helen, additional, Veeran, Shaminee, additional, Veislinger, Aurélie, additional, Vencken, Sebastian, additional, Ventura, Sara, additional, Verbon, Annelies, additional, Vidal, José Ernesto, additional, Vieira, César, additional, Vijayan, Deepak, additional, Villanueva, Joy Ann, additional, Villar, Judit, additional, Villeneuve, Pierre-Marc, additional, Villoldo, Andrea, additional, Vinh Chau, Nguyen Van, additional, Visseaux, Benoit, additional, Visser, Hannah, additional, Vitiello, Chiara, additional, Vonkeman, Harald, additional, Vuotto, Fanny, additional, Wahab, Noor Hidayu, additional, Wahab, Suhaila Abdul, additional, Wahid, Nadirah Abdul, additional, Wainstein, Marina, additional, Wan Muhd Shukeri, Wan Fadzlina, additional, Wang, Chih-Hsien, additional, Webb, Steven Anthony, additional, Wei, Jia, additional, Weil, Katharina, additional, Wen, Tan Pei, additional, Wesselius, Sanne, additional, West, T. Eoin, additional, Wham, Murray, additional, Whelan, Bryan, additional, White, Nicole, additional, Wicky, Paul Henri, additional, Wiedemann, Aurélie, additional, Wijaya, Surya Otto, additional, Wille, Keith, additional, Willems, Suzette, additional, Williams, Virginie, additional, Wils, Evert-Jan, additional, Wing Yiu, Ng, additional, Wong, Calvin, additional, Wong, Teck Fung, additional, Wong, Xin Ci, additional, Wong, Yew Sing, additional, Xian, Gan Ee, additional, Xian, Lim Saio, additional, Xuan, Kuan Pei, additional, Xynogalas, Ioannis, additional, Yacoub, Sophie, additional, Yakop, Siti Rohani Binti Mohd, additional, Yamazaki, Masaki, additional, Yazdanpanah, Yazdan, additional, Yee Liang Hing, Nicholas, additional, Yelnik, Cécile, additional, Yeoh, Chian Hui, additional, Yerkovich, Stephanie, additional, Yokoyama, Toshiki, additional, Yonis, Hodane, additional, Yousif, Obada, additional, Yuliarto, Saptadi, additional, Zaaqoq, Akram, additional, Zabbe, Marion, additional, Zacharowski, Kai, additional, Zahid, Masliza, additional, Zahran, Maram, additional, Zaidan, Nor Zaila Binti, additional, Zambon, Maria, additional, Zambrano, Miguel, additional, Zanella, Alberto, additional, Zawadka, Konrad, additional, Zaynah, Nurul, additional, Zayyad, Hiba, additional, Zoufaly, Alexander, additional, and Zucman, David, additional

Published
2021
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17. Abstract P172: Association of Interleukin 6 With Hypertension in HIV Positive Participants in the Strategic Timing of Antiretroviral Treatment (START) Trial

Author

Adrian Palfreeman, Shweta Sharma, Mamta K Jain, Lama Ghazi, Daniel Murray, Jason V. Baker, Paul E. Drawz, James D. Neaton, and Coca Necsoi

Subjects
medicine.medical_specialty, biology, business.industry, Human immunodeficiency virus (HIV), medicine.disease_cause, Physiology (medical), Internal medicine, medicine, Antiretroviral treatment, biology.protein, Cardiology and Cardiovascular Medicine, Association (psychology), business, Interleukin 6
Abstract

Introduction: The association between hypertension (HTN) and inflammation [e.g., estimated via interleukin 6 (IL-6)] in HIV positive persons who have a CD4+ count greater than 500 cells/mm 3 has not been well established. Methods: We studied HTN in the START trial, a randomized study of immediate vs. deferred antiretroviral therapy (ART) in HIV-positive adults who were ART naïve and had a CD4+ count greater than 500 cells/mm 3 . Our analysis included 4249 of the 4,684 HIV positive persons enrolled in START who had no history of cardiovascular disease and had IL-6 measured at baseline. HTN (prevalence at baseline or incidence) was defined as having a systolic BP ≥140 mm Hg, or a diastolic BP ≥90 mm Hg, or use of BP-lowering therapy. Logistic regression and discrete Cox proportional hazard models were used to test the association between IL-6 and HTN prevalence and incidence. Sensitivity analysis were used to test the association between systolic and diastolic BP and IL-6 levels. Results: HTN was prevalent in 18.9% of the cohort at entry. The median age of participants was 36 years, 27% were female, median CD4 + cell count at entry was 651 cells/mm 3 and median HIV RNA level was 13090 copies/mL. In univariate analysis, HTN was significantly associated with higher IL-6 levels at baseline [OR per doubling of IL-6:1.28, 95%CI (1.18, 1.39)]. This association was attenuated and no longer significant after adjusting for race, age, gender, BMI, diabetes, smoking, RNA and CD4+ levels [OR per doubling of IL-6:1.10, 95%CI (0.99, 1.20)]. The reduced OR was primarily due BMI and age, both which were strongly related to HTN. Overall incidence of HTN was 6.9 cases per 100 person year. Baseline IL-6 was not associated with risk of incident HTN in the crude and fully adjusted model [HR per doubling of IL-6:0.98, 95%CI (0.90, 1.10) in adjusted analysis]. This association did not differ by treatment group (p for interaction=0.21). Risk factors such as age, black race, BMI, and male gender were associated with incident HTN. Continuous systolic and diastolic BP were not significantly associated with IL-6 at baseline or in follow-up analyses. Conclusions: IL-6 was not associated with HTN in HIV positive participants with CD4+ counts greater than 500 cells/mm 3 after adjusting for factors known to be associated with HTN and inflammation. Furthermore, baseline IL-6 level was not associated with incident HTN, nor with continuous BP measures. Rather, HTN development was associated with traditional risk factors such as age, race, gender and BMI.

Published
2019
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18. Characteristics of non-AIDS-defining malignancies in the HAART era: a clinico-epidemiological study

Author

Stéphane De Wit, Marc Delforge, Nathan Clumeck, Nicolas Dauby, and Valentina Coca Necsoi

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, Anti-HIV Agents, HIV Infections, Santé publique, Cohort Studies, Belgium, Acquired immunodeficiency syndrome (AIDS), Antiretroviral Therapy, Highly Active, Neoplasms, Epidemiology, medicine, Humans, Anal cancer, Retrospective Studies, business.industry, Research, Public health, Incidence (epidemiology), Public Health, Environmental and Occupational Health, Retrospective cohort study, Middle Aged, medicine.disease, Cancérologie, Médecine interne, Infectious Diseases, Cohort, Immunology, Female, business, Cohort study
Abstract

Journal Article, SCOPUS: ar.j, info:eu-repo/semantics/published

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19. Improving the evidence for indicator condition guided HIV testing in Europe: Results from the HIDES II Study - 2012 - 2015.

Author

Dorthe Raben, Ann Kathleen Sullivan, Amanda Mocroft, Galyna Kutsyna, Vesna Hadžiosmanović, Anna Vassilenko, Nikoloz Chkhartisvili, Viktar Mitsura, Court Pedersen, Jane Anderson, Josip Begovac, Ulrik Bak Dragsted, Barbara Bertisch, Anna Grzeszczuk, Jane Minton, Valentina Coca Necsoi, Maria Kitchen, Faiza Ajana, Anton Sokhan, Laura Comi, Paymaneh Farazmand, Dragica Pesut, Stephane De Wit, José Maria Gatell, Brian Gazzard, Antonella d'Arminio Monforte, Jürgen Kurt Rockstroh, Yazdan Yazdanpanah, Karen Champenois, Marie Louise Jakobsen, Jens Dilling Lundgren, and HIDES Study Group

Subjects
Medicine, Science
Abstract

BackgroundIt is cost-effective to perform an HIV test in people with specific indicator conditions (IC) with an undiagnosed HIV prevalence of at least 0.1%. Our aim was to determine the HIV prevalence for 14 different conditions across 20 European countries.MethodsIndividuals aged 18-65 years presenting for care with one of 14 ICs between January 2012 and June 2014 were included and routinely offered an HIV test. Logistic regression assessed factors associated with testing HIV positive. Patients presenting with infectious mononucleosis-like syndrome (IMS) were recruited up until September 2015.ResultsOf 10,877 patients presenting with an IC and included in the analysis, 303 tested positive (2.8%; 95% CI 2.5-3.1%). People presenting with an IC in Southern and Eastern Europe were more likely to test HIV positive as were people presenting with IMS, lymphadenopathy and leukocytopenia/ thrombocytopenia. One third of people diagnosed with HIV after presenting with IMS reported a negative HIV test in the preceding 12 months. Of patients newly diagnosed with HIV where data was available, 92.6% were promptly linked to care; of these 10.4% were reported lost to follow up or dead 12 months after diagnosis.ConclusionThe study showed that 10 conditions had HIV prevalences > 0.1%. These 10 ICs should be adopted into HIV testing and IC specialty guidelines. As IMS presentation can mimic acute HIV sero-conversion and has the highest positivity rate, this IC in particular affords opportunities for earlier diagnosis and public health benefit.

Published
2019
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20. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Author

Abbas, Ali, Abdukahil, Sheryl Ann, Abdulkadir, Nurul Najmee, Abe, Ryuzo, Abel, Laurent, Absil, Lara, Jabal, Kamal Abu, Zayyad, Hiba Abu, Acharya, Subhash, Acker, Andrew, Adachi, Shingo, Adam, Elisabeth, Adriano, Enrico, Adrião, Diana, Ageel, Saleh Al, Ahmed, Shakeel, Aiello, Marina, Ainscough, Kate, Airlangga, Eka, Aisa, Tharwat, Hssain, Ali Ait, Tamlihat, Younes Ait, Akimoto, Takako, Akmal, Ernita, Qasim, Eman Al, Al-dabbous, Tala, Al-Fares, Abdulrahman, Alalqam, Razi, Alberti, Angela, Alegesan, Senthilkumar, Alegre, Cynthia, Alessi, Marta, Alex, Beatrice, Alexandre, Kévin, Alfoudri, Huda, Ali, Adam, Ali, Imran, Shah, Naseem Ali, Sheikh, Naseem Ali, Alidjnou, Kazali Enagnon, Aliudin, Jeffrey, Alkhafajee, Qabas, Allavena, Clotilde, Allou, Nathalie, Altaf, Aneela, Alves, João, Alves, João Melo, Alves, Rita, Amaral, Maria, Amira, Nur, Ammerlaan, Heidi, Ampaw, Phoebe, Andini, Roberto, Andrejak, Claire, Angheben, Andrea, Angoulvant, François, Ansart, Séverine, Anthonidass, Sivanesen, Antonelli, Massimo, de Brito, Carlos Alexandre Antunes, Anwar, Kazi Rubayet, Apriyana, Ardiyan, Arabi, Yaseen, Aragao, Irene, Arancibia, Francisco, Araujo, Carolline, Arcadipane, Antonio, Archambault, Patrick, Arenz, Lukas, Arlet, Jean-Benoît, Arnold-Day, Christel, Aroca, Ana, Arora, Lovkesh, Arora, Rakesh, Artaud-Macari, Elise, Aryal, Diptesh, Asaki, Motohiro, Asensio, Angel, Ashley, Elizabeth, Ashraf, Muhammad, Asif, Namra, Asim, Mohammad, Assie, Jean Baptiste, Asyraf, Amirul, Atique, Anika, Attanyake, A. M. Udara Lakshan, Auchabie, Johann, Aumaitre, Hugues, Auvet, Adrien, Axelsen, Eyvind W., Azemar, Laurène, Azoulay, Cecile, Bach, Benjamin, Bachelet, Delphine, Badr, Claudine, Bævre-Jensen, Roar, Baig, Nadia, Baillie, J. Kenneth, Baird, J Kevin, Bak, Erica, Bakakos, Agamemnon, Bakar, Nazreen Abu, Bal, Andriy, Balakrishnan, Mohanaprasanth, Balan, Valeria, Bani-Sadr, Firouzé, Barbalho, Renata, Barbosa, Nicholas Yuri, Barclay, Wendy S., Barnett, Saef Umar, Barnikel, Michaela, Barrasa, Helena, Barrelet, Audrey, Barrigoto, Cleide, Bartoli, Marie, Bartone, Cheryl, Baruch, Joaquín, Bashir, Mustehan, Basmaci, Romain, Basri, Muhammad Fadhli Hassin, Battaglini, Denise, Bauer, Jules, Rincon, Diego Fernando Bautista, Dow, Denisse Bazan, Beane, Abigail, Bedossa, Alexandra, Bee, Ker Hong, Begum, Husna, Behilill, Sylvie, Beiruti, Karine, Beishuizen, Albertus, Beljantsev, Aleksandr, Bellemare, David, Beltrame, Anna, Beltrão, Beatriz Amorim, Beluze, Marine, Benech, Nicolas, Benjiman, Lionel Eric, Benkerrou, Dehbia, Bennett, Suzanne, Bento, Luís, Berdal, Jan-Erik, Bergeaud, Delphine, Bergin, Hazel, Sobrino, José Luis Bernal, Bertoli, Giulia, Bertolino, Lorenzo, Bessis, Simon, Betz, Adam, Bevilcaqua, Sybille, Bezulier, Karine, Bhatt, Amar, Bhavsar, Krishna, Bianchi, Isabella, Bianco, Claudia, Bidin, Farah Nadiah, Singh, Moirangthem Bikram, Bin Humaid, Felwa, Bin Kamarudin, Mohd Nazlin, Bissuel, François, Biston, Patrick, Bitker, Laurent, Bitton, Jonathan, Blanco-Schweizer, Pablo, Blier, Catherine, Bloos, Frank, Blot, Mathieu, Blumberg, Lucille, Boccia, Filomena, Bodenes, Laetitia, Bogaarts, Alice, Bogaert, Debby, Boivin, Anne-Hélène, Bolze, Pierre-Adrien, Bompart, François, Bonelli, Patrizia, Bonfasius, Aurelius, Borges, Diogo, Borie, Raphaël, Bosse, Hans Martin, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bouchaud, Olivier, Bouchez, Sabelline, Bouhmani, Dounia, Bouhour, Damien, Bouiller, Kévin, Bouillet, Laurence, Bouisse, Camile, Bounphiengsy, Thipsavanh, Bountthasavong, Latsaniphone, Boureau, Anne-Sophie, Bourke, John, Bouscambert, Maude, Bousquet, Aurore, Bouziotis, Jason, Boxma, Bianca, Boyer-Besseyre, Marielle, Boylan, Maria, Bozza, Fernando Augusto, Braconnier, Axelle, Braga, Cynthia, Brandenburger, Timo, Monteiro, Filipa Brás, Brazzi, Luca, Breen, Dorothy, Breen, Patrick, Brickell, Kathy, Browne, Alex, Browne, Shaunagh, Brozzi, Nicolas, Brunvoll, Sonja Hjellegjerde, Brusse-Keizer, Marjolein, Buchtele, Nina, Buesaquillo, Christian, Bugaeva, Polina, Buisson, Marielle, Buonsenso, Danilo, Burhan, Erlina, Burrell, Aidan, Bustos, Ingrid G., Butnaru, Denis, Cabie, André, Cabral, Susana, Caceres, Eder, Cadoz, Cyril, Callahan, Mia, Calligy, Kate, Calvache, Jose Andres, Caminiti, Caterina, Camões, João, Campana, Valentine, Campbell, Paul, Campisi, Josie, Canepa, Cecilia, Cantero, Mireia, Caraux-Paz, Pauline, Cárcel, Sheila, Cardellino, Chiara Simona, Cardoso, Filipa, Cardoso, Filipe, Cardoso, Nelson, Cardoso, Sofia, Carelli, Simone, Carlacci, Francesca, Carlier, Nicolas, Carmoi, Thierry, Carney, Gayle, Carqueja, Inês, Carret, Marie-Christine, Carrier, François Martin, Carroll, Ida, Carson, Gail, Carvalho, Leonor, Casanova, Maire-Laure, Cascão, Mariana, Casey, Siobhan, Casimiro, José, Cassandra, Bailey, Castañeda, Silvia, Castanheira, Nidyanara, Castor-Alexandre, Guylaine, Castrillón, Henry, Castro, Ivo, Catarino, Ana, Catherine, François-Xavier, Cattaneo, Paolo, Cavalin, Roberta, Cavalli, Giulio Giovanni, Cavayas, Alexandros, Ceccato, Adrian, Cervantes-Gonzalez, Minerva, Chair, Anissa, Chakveatze, Catherine, Chan, Adrienne, Chand, Meera, Auger, Christelle Chantalat, Chapplain, Jean-Marc, Chas, Julie, Chatterjee, Allegra, Chaudry, Mobin, Iñiguez, Jonathan Samuel Chávez, Chen, Anjellica, Chen, Yih-Sharng, Cheng, Matthew Pellan, Cheret, Antoine, Chetta, Alfredo Antonio, Chiarabini, Thibault, Chica, Julian, Chidambaram, Suresh Kumar, Tho, Leong Chin, Chirouze, Catherine, Chiumello, Davide, Cho, Hwa Jin, Cho, Sung-Min, Cholley, Bernard, Chommanam, Danoy, Chopin, Marie-Charlotte, Chow, Ting Soo, Chow, Yock Ping, Christy, Nathaniel, Chua, Hiu Jian, Chua, Jonathan, Cidade, Jose Pedro, Herreros, José Miguel Cisneros, Citarella, Barbara Wanjiru, Ciullo, Anna, Clarke, Emma, Clarke, Jennifer, Granado, Rolando Claure-Del, Clohisey, Sara, Cobb, Perren J., Codan, Cassidy, Cody, Caitriona, Coelho, Alexandra, Coles, Megan, Colin, Gwenhaël, Collins, Michael, Colombo, Sebastiano Maria, Combs, Pamela, Connor, Marie, Conrad, Anne, Contreras, Sofía, Conway, Elaine, Cooke, Graham S., Copland, Mary, Cordel, Hugues, Corley, Amanda, Cornelis, Sabine, Cornet, Alexander Daniel, Corpuz, Arianne Joy, Cortegiani, Andrea, Corvaisier, Grégory, Costigan, Emma, Couffignal, Camille, Couffin-Cadiergues, Sandrine, Courtois, Roxane, Cousse, Stéphanie, Cregan, Rachel, D’Orleans, Charles Crepy, Croonen, Sabine, Crowl, Gloria, Crump, Jonathan, Cruz, Claudina, Berm, Juan Luis Cruz, Rojo, Jaime Cruz, Csete, Marc, Cucino, Alberto, Cullen, Ailbhe, Cummings, Matthew, Curley, Ger, Curley, Gerard, Curlier, Elodie, Curran, Colleen, Custodio, Paula, D’Amico, Federico, D’Aragon, Frédérick, D’Ortenzio, Eric, da Silva Filipe, Ana, Da Silveira, Charlene, Dabaliz, Al-Awwab, Dagens, Andrew, Dahl, John Arne, Dahly, Darren, Dalton, Heidi, Dalton, Jo, Daly, Seamus, Daneman, Nick, Daniel, Corinne, Dankwa, Emmanuelle A, Dantas, Jorge, de Boer, Mark, de Loughry, Gillian, de Mendoza, Diego, De Montmollin, Etienne, de Oliveira França, Rafael Freitas, Oliveira, Ana Isabel de Pinho, De Rosa, Rosanna, De Rose, Cristina, de Silva, Thushan, de Vries, Peter, Deacon, Jillian, Dean, David, Debard, Alexa, DeBenedictis, Bianca, Debray, Marie-Pierre, DeCastro, Nathalie, Dechert, William, Deconninck, Lauren, Decours, Romain, Defous, Eve, Delacroix, Isabelle, Delaveuve, Eric, Delavigne, Karen, Delfos, Nathalie M., Deligiannis, Ionna, Dell’Amore, Andrea, Delmas, Christelle, Delobel, Pierre, Delsing, Corine, Demonchy, Elisa, Denis, Emmanuelle, Deplanque, Dominique, Depuydt, Pieter, Desai, Mehul, Descamps, Diane, Desvallées, Mathilde, Dewayanti, Santi, Dhanger, Pathik, Diallo, Alpha, Diamantis, Sylvain, Dias, André, Dias, Andrea, Diaz, Juan Jose, Diaz, Priscila, Diaz, Rodrigo, Didier, Kévin, Diehl, Jean-Luc, Dieperink, Wim, Dimet, Jérôme, Dinot, Vincent, Diop, Fara, Diouf, Alphonsine, Dishon, Yael, Djossou, Félix, Docherty, Annemarie B., Doherty, Helen, Dondorp, Arjen M, Dong, Andy, Donnelly, Christl A., Donnelly, Maria, Donohue, Chloe, Donohue, Sean, Donohue, Yoann, Doran, Peter, Dorival, Céline, Douangdala, Phouvieng, Douglas, James Joshua, Douma, Renee, Dournon, Nathalie, Downer, Triona, Downey, Joanne, Downing, Mark, Drake, Tom, Driscoll, Aoife, Dror, Amiel A., Dryden, Murray, Fonseca, Claudio Duarte, Dubee, Vincent, Dubos, François, Dubot-Pérès, Audrey, Ducancelle, Alexandre, Duculan, Toni, Dudman, Susanne, Duggal, Abhijit, Dunand, Paul, Dunning, Jake, Duplaix, Mathilde, Durante-Mangoni, Emanuele, Durham III, Lucian, Dussol, Bertrand, Duthoit, Juliette, Duval, Xavier, Dyrhol-Riise, Anne Margarita, Ean, Sim Choon, Echeverria-Villalobos, Marco, Economopoulos, Giorgio, Edelstein, Michael, Egan, Siobhan, Eggesbø, Linn Margrete, Eira, Carla, El Sanharawi, Mohammed, Elapavaluru, Subbarao, Elharrar, Brigitte, Ellerbroek, Jacobien, Ellingjord-Dale, Merete, Eloy, Philippine, Elshazly, Tarek, Elyazar, Iqbal, Enderle, Isabelle, Endo, Tomoyuki, Eng, Chan Chee, Engelmann, Ilka, Enouf, Vincent, Epaulard, Olivier, Escher, Martina, Esperatti, Mariano, Esperou, Hélène, Esposito-Farese, Marina, Estevão, João, Etienne, Manuel, Ettalhaoui, Nadia, Everding, Anna Greti, Evers, Mirjam, Fabre, Isabelle, Fabre, Marc, Faheem, Amna, Fahy, Arabella, Fairfield, Cameron J., Fakar, Zul, Fareed, Komal, Faria, Pedro, Farooq, Ahmed, Fateena, Hanan, Fatoni, Arie Zainul, Faure, Karine, Favory, Raphaël, Fayed, Mohamed, Feely, Niamh, Feeney, Laura, Fernandes, Jorge, Fernandes, Marília Andreia, Fernandes, Susana, Ferrand, François-Xavier, Devouge, Eglantine Ferrand, Ferrão, Joana, Ferrari, Carlo, Ferraz, Mário, Ferreira, Benigno, Ferreira, Isabel, Ferreira, Sílvia, Ferrer-Roca, Ricard, Ferriere, Nicolas, Ficko, Céline, Figueiredo-Mello, Claudia, Finlayson, William, Fiorda, Juan, Flament, Thomas, Flateau, Clara, Fletcher, Tom, Florio, Letizia Lucia, Flynn, Brigid, Flynn, Deirdre, Fogliazza, Federica, Foley, Claire, Foley, Jean, Fomin, Victor, Fonseca, Tatiana, Fontela, Patricia, Forsyth, Simon, Foster, Denise, Foti, Giuseppe, Fourn, Erwan, Fowler, Robert A., Fraher, Marianne, Franch-Llasat, Diego, Fraser, Christophe, Fraser, John F, Freire, Marcela Vieira, Ribeiro, Ana Freitas, French, Craig, Friedrich, Caren, Fritz, Ricardo, Fry, Stéphanie, Fuentes, Nora, Fukuda, Masahiro, Argin, G, Gaborieau, Valérie, Gaci, Rostane, Gagliardi, Massimo, Gagnard, Jean-Charles, Gagné, Nathalie, Gagneux-Brunon, Amandine, Gaião, Sérgio, Skeie, Linda Gail, Gallagher, Phil, Curto, Elena Gallego, Gamble, Carrol, Gani, Yasmin, Garan, Arthur, Garcia, Rebekha, Barrio, Noelia García, Garcia-Diaz, Julia, Garcia-Gallo, Esteban, Garimella, Navya, Garofalo, Federica, Garot, Denis, Garrait, Valérie, Gauli, Basanta, Gault, Nathalie, Gavin, Aisling, Gavrylov, Anatoliy, Gaymard, Alexandre, Gebauer, Johannes, Geraud, Eva, Morlaes, Louis Gerbaud, Germano, Nuno, Ghisulal, Praveen Kumar, Ghosn, Jade, Giani, Marco, Giaquinto, Carlo, Gibson, Jess, Gigante, Tristan, Gilg, Morgane, Gilroy, Elaine, Giordano, Guillermo, Girvan, Michelle, Gissot, Valérie, Gitaka, Jesse, Giwangkancana, Gezy, Glikman, Daniel, Glybochko, Petr, Gnall, Eric, Goco, Geraldine, Goehringer, François, Goepel, Siri, Goffard, Jean-Christophe, Goh, Jin Yi, Golob, Jonathan, Gomes, Rui, Gomez, Kyle, Gómez-Junyent, Joan, Gominet, Marie, Gonçalves, Bronner P., Gonzalez, Alicia, Gordon, Patricia, Gorelik, Yanay, Gorenne, Isabelle, Goubert, Laure, Goujard, Cécile, Goulenok, Tiphaine, Grable, Margarite, Graf, Jeronimo, Grandin, Edward Wilson, Granier, Pascal, Grasselli, Giacomo, Grazioli, Lorenzo, Green, Christopher A., Greene, Courtney, Greenhalf, William, Greffe, Segolène, Grieco, Domenico Luca, Griffee, Matthew, Griffiths, Fiona, Grigoras, Ioana, Groenendijk, Albert, Lordemann, Anja Grosse, Gruner, Heidi, Gu, Yusing, Guarracino, Fabio, Guedj, Jérémie, Guego, Martin, Guellec, Dewi, Guerguerian, Anne-Marie, Guerreiro, Daniela, Guery, Romain, Guillaumot, Anne, Guilleminault, Laurent, de Castro, Maisa Guimarães, Guimard, Thomas, Haalboom, Marieke, Haber, Daniel, Habraken, Hannah, Hachemi, Ali, Hackmann, Amy, Hadri, Nadir, Haidri, Fakhir, Hakak, Sheeba, Hall, Adam, Hall, Matthew, Halpin, Sophie, Hameed, Jawad, Hamer, Ansley, Hamers, Raph L., Hamidfar, Rebecca, Hammarström, Bato, Hammond, Terese, Han, Lim Yuen, Haniffa, Rashan, Hao, Kok Wei, Hardwick, Hayley, Harrison, Ewen M., Harrison, Janet, Harrison, Samuel Bernard Ekow, Hartman, Alan, Hasan, Mohd Shahnaz, Hashmi, Junaid, Hashmi, Madiha, Hayes, Ailbhe, Hays, Leanne, Heerman, Jan, Heggelund, Lars, Hendry, Ross, Hennessy, Martina, Henriquez-Trujillo, Aquiles, Hentzien, Maxime, Hernandez-Montfort, Jaime, Herr, Daniel, Hershey, Andrew, Hesstvedt, Liv, Hidayah, Astarini, Higgins, Dawn, Higgins, Eibhilin, Hinchion, Rita, Hinton, Samuel, Hiraiwa, Hiroaki, Hirkani, Haider, Hitoto, Hikombo, Ho, Antonia, Ho, Yi Bin, Hoctin, Alexandre, Hoffmann, Isabelle, Hoh, Wei Han, Hoiting, Oscar, Holt, Rebecca, Holter, Jan Cato, Horby, Peter, Horcajada, Juan Pablo, Hoshino, Koji, Hoshino, Kota, Houas, Ikram, Hough, Catherine L., Houltham, Stuart, Hsu, Jimmy Ming-Yang, Hulot, Jean-Sébastien, Huo, Stella, Hussain, Iqbal, Ijaz, Samreen, Illes, Hajnal-Gabriela, Imbert, Patrick, Imran, Mohammad, Sikander, Rana Imran, Imtiaz, Aftab, Inácio, Hugo, Dominguez, Carmen Infante, Ing, Yun Sii, Iosifidis, Elias, Ippolito, Mariachiara, Isgett, Sarah, Isidoro, Tiago, Ismail, Nadiah, Isnard, Margaux, Istre, Mette Stausland, Itai, Junji, Ito, Asami, Ivulich, Daniel, Jaafar, Danielle, Jaafoura, Salma, Jabot, Julien, Jackson, Clare, Jamieson, Nina, Jaquet, Pierre, Jassat, Waasila, Jaud-Fischer, Coline, Jaureguiberry, Stéphane, Javidfar, Jeffrey, Jaworsky, Denise, Jego, Florence, Jelani, Anilawati Mat, Jenum, Synne, Jimbo-Sotomayor, Ruth, Joe, Ong Yiaw, García, Ruth N. Jorge, Jørgensen, Silje Bakken, Joseph, Cédric, Joseph, Mark, Joshi, Swosti, Jourdain, Mercé, Jouvet, Philippe, June, Jennifer, Jung, Anna, Jung, Hanna, Juzar, Dafsah, Kafif, Ouifiya, Kaguelidou, Florentia, Kaisbain, Neerusha, Kaleesvran, Thavamany, Kali, Sabina, Kalicinska, Alina, Kalleberg, Karl Trygve, Kalomoiri, Smaragdi, Kamaluddin, Muhammad Aisar Ayadi, Kamaruddin, Zul Amali Che, Kamarudin, Nadiah, Kamineni, Kavita, Kandamby, Darshana Hewa, Kandel, Chris, Kang, Kong Yeow, Kanwal, Darakhshan, Kanyawati, Dyah, Karpayah, Pratap, Karsies, Todd, Kartsonaki, Christiana, Kasugai, Daisuke, Kataria, Anant, Katz, Kevin, Kaur, Aasmine, Kawasaki, Tatsuya, Kay, Christy, Keane, Hannah, Keating, Seán, Kedia, Pulak, Kelly, Andrea, Kelly, Aoife, Kelly, Claire, Kelly, Niamh, Kelly, Sadie, Kelly, Yvelynne, Kelsey, Maeve, Kennedy, Ryan, Kennon, Kalynn, Keomany, Sommay, Kernan, Maeve, Kerroumi, Younes, Keshav, Sharma, Kestelyn, Evelyne, Khalid, Imrana, Khalid, Osama, Khalil, Antoine, Khan, Coralie, Khan, Irfan, Khan, Quratul Ain, Khanal, Sushil, Khatak, Abid, Khawaja, Amin, Kherajani, Krish, Kho, Michelle E., Khoo, Denisa, Khoo, Ryan, Khoo, Saye, Khoso, Nasir, Kiat, Khor How, Kida, Yuri, Kihuga, Harrison, Kiiza, Peter, Granerud, Beathe Kiland, Kildal, Anders Benjamin, Kim, Jae Burm, Kimmoun, Antoine, Kindgen-Milles, Detlef, King, Alexander, Kitamura, Nobuya, Kjetland, Eyrun Floerecke Kjetland, Klenerman, Paul, Klont, Rob, Bekken, Gry Kloumann, Knight, Stephen R, Kobbe, Robin, Kodippily, Chamira, Vasconcelos, Malte Kohns, Koirala, Sabin, Komatsu, Mamoru, Korten, Volkan, Kosgei, Caroline, Kpangon, Arsène, Krawczyk, Karolina, Krishnan, Sudhir, Krishnan, Vinothini, Kruglova, Oksana, Kumar, Deepali, Kumar, Ganesh, Kumar, Mukesh, Vecham, Pavan Kumar, Kuriakose, Dinesh, Kurtzman, Ethan, Kusumastuti, Neurinda Permata, Kutsogiannis, Demetrios, Kutsyna, Galyna, Kyriakoulis, Konstantinos, L’Her, Erwan, Lachatre, Marie, Lacoste, Marie, Laffey, John G., Lagrange, Marie, Laine, Fabrice, Lairez, Olivier, Lakhey, Sanjay, Lalueza, Antonio, Lambert, Marc, Lamontagne, François, Langelot-Richard, Marie, Langlois, Vincent, Lantang, Eka Yudha, Lanza, Marina, Laouénan, Cédric, Laribi, Samira, Lariviere, Delphine, Lasry, Stéphane, Lath, Sakshi, Latif, Naveed, Launay, Odile, Laureillard, Didier, Lavie-Badie, Yoan, Law, Andrew, Law, Andy, Lawrence, Cassie, Lawrence, Teresa, Le, Minh, Le Bihan, Clément, Le Bris, Cyril, Le Falher, Georges, Le Fevre, Lucie, Le Hingrat, Quentin, Le Maréchal, Marion, Le Mestre, Soizic, Le Moal, Gwenaël, Le Moing, Vincent, Le Nagard, Hervé, Le Turnier, Paul, Leal, Ema, Santos, Marta Leal, Lee, Biing Horng, Lee, Heng Gee, Lee, James, Lee, Su Hwan, Lee, Todd C., Lee, Yi Lin, Leeming, Gary, Lefebvre, Bénédicte, Lefebvre, Laurent, Lefevre, Benjamin, LeGac, Sylvie, Lelievre, Jean-Daniel, Lellouche, François, Lemaignen, Adrien, Lemee, Véronique, Lemeur, Anthony, Lemmink, Gretchen, Lene, Ha Sha, Lennon, Jenny, León, Rafael, Leone, Marc, Leone, Michela, Lepiller, Quentin, Lescure, François-Xavier, Lesens, Olivier, Lesouhaitier, Mathieu, Lester-Grant, Amy, Letizia, Andrew, Levy, Bruno, Levy, Yves, Levy-Marchal, Claire, Lewandowska, Katarzyna, Bassi, Gianluigi Li, Liang, Janet, Liaquat, Ali, Liegeon, Geoffrey, Lim, Kah Chuan, Lim, Wei Shen, Lima, Chantre, Lina, Bruno, Lina, Lim, Lind, Andreas, Lingad, Maja Katherine, Lingas, Guillaume, Lion-Daolio, Sylvie, Lissauer, Samantha, Liu, Keibun, Livrozet, Marine, Lizotte, Patricia, Loforte, Antonio, Lolong, Navy, Loon, Leong Chee, Lopes, Diogo, Lopez-Colon, Dalia, Loschner, Anthony L., Loubet, Paul, Loufti, Bouchra, Louis, Guillame, Lourenco, Silvia, Lovelace-Macon, Lara, Low, Lee Lee, Lowik, Marije, Loy, Jia Shyi, Lucet, Jean Christophe, Bermejo, Carlos Lumbreras, Luna, Carlos M., Lungu, Olguta, Luong, Liem, Luque, Nestor, Luton, Dominique, Lwin, Nilar, Lyons, Ruth, Maasikas, Olavi, Mabiala, Oryane, MacDonald, Sarah, Machado, Moïse, Macheda, Gabriel, Sanchez, Juan Macias, Madhok, Jai, Madiha, Hashmi, de la Calle, Guillermo Maestro, Magara, Jacob, Maglietta, Giuseppe, Mahieu, Rafael, Mahy, Sophie, Maia, Ana Raquel, Maier, Lars S., Maillet, Mylène, Maitre, Thomas, Majori, Maria, Malfertheiner, Maximilian, Malik, Nadia, Mallon, Paddy, Maltez, Fernando, Malvy, Denis, Mammi, Patrizia, Manda, Victoria, Mandei, Jose M., Mandelbrot, Laurent, Manetta, Frank, Mankikian, Julie, Manning, Edmund, Manuel, Aldric, Malaque, Ceila Maria Sant’Ana, Marino, Daniel, Marino, Flávio, Markowicz, Samuel, Eid, Charbel Maroun, Marques, Ana, Marquis, Catherine, Marsh, Brian, Marsh, Laura, Marshal, Megan, Marshall, John, Martelli, Celina Turchi, Martin, Dori-Ann, Martin, Emily, Martin-Blondel, Guillaume, Martin-Loeches, Ignacio, Martin-Quiros, Alejandro, Martinelli, Alessandra, Martinot, Martin, Martins, Ana, Martins, João, Martins, Nuno, Rego, Caroline Martins, Martucci, Gennaro, Martynenko, Olga, Marwali, Eva Miranda, Marzukie, Marsilla, Jimenez, Juan Fernado Masa, Maslove, David, Mason, Phillip, Mason, Sabina, Masood, Sobia, Nor, Basri Mat, Matan, Moshe, Fernandes, Henrique Mateus, Mathew, Meghena, Mathieu, Daniel, Mattei, Mathieu, Matulevics, Romans, Maulin, Laurence, Maxwell, Michael, Maynar, Javier, Mayxay, Mayfong, Mazzoni, Thierry, Mc Evoy, Natalie, Mc Sweeney, Lisa, McArthur, Colin, McCarthy, Aine, McCarthy, Anne, McCloskey, Colin, McConnochie, Rachael, McDermott, Sherry, McDonald, Sarah E., McElroy, Aine, McElwee, Samuel, McEneany, Victoria, McGeer, Allison, McKay, Chris, McKeown, Johnny, McLean, Kenneth A., McNally, Paul, McNicholas, Bairbre, McPartlan, Elaine, Meaney, Edel, Mear-Passard, Cécile, Mechlin, Maggie, Meher, Maqsood, Mehkri, Omar, Mele, Ferruccio, Melo, Luis, Memon, Kashif, Mendes, Joao, Menkiti, Ogechukwu, Menon, Kusum, Mentré, France, Mentzer, Alexander J., Mercier, Emmanuelle, Mercier, Noémie, Merckx, Antoine, Mergeay-Fabre, Mayka, Mergler, Blake, Merson, Laura, Meschi, Tiziana, Mesquita, António, Meta, Roberta, Metwally, Osama, Meybeck, Agnès, Meyer, Dan, Meynert, Alison M., Meysonnier, Vanina, Meziane, Amina, Mezidi, Mehdi, Michelagnoli, Giuliano, Michelanglei, Céline, Michelet, Isabelle, Mihelis, Efstathia, Mihnovit, Vladislav, Miranda-Maldonado, Hugo, Misnan, Nor Arisah, Mohamed, Nik Nur Eliza, Mohamed, Tahira Jamal, Moin, Asma, Molina, David, Molinos, Elena, Molloy, Brenda, Mone, Mary, Monteiro, Agostinho, Montes, Claudia, Montrucchio, Giorgia, Moore, Sarah, Moore, Shona C., Cely, Lina Morales, Moro, Lucia, Tutillo, Diego Rolando Morocho, Morton, Ben, Motherway, Catherine, Motos, Ana, Mouquet, Hugo, Perrot, Clara Mouton, Moyet, Julien, Mudara, Caroline, Mufti, Aisha Kalsoom, Muh, Ng Yong, Muhamad, Dzawani, Mullaert, Jimmy, Müller, Fredrik, Müller, Karl Erik, Munblit, Daniel, Muneeb, Syed, Munir, Nadeem, Munshi, Laveena, Murphy, Aisling, Murphy, Lorna, Murris, Marlène, Murthy, Srinivas, Musaab, Himed, Mutti, Carlotta, Muvindi, Himasha, Muyandy, Gugapriyaa, Myrodia, Dimitra Melia, Mohd-Hanafiah, Farah Nadia, Nagpal, Dave, Narasimhan, Mangala, Narayanan, Nageswaran, Khan, Rashid Nasim, Nazerali-Maitland, Alasdair, Neant, Nadège, Neb, Holger, Necsoi, Coca, Nekliudov, Nikita A., Nelwan, Erni, Neto, Raul, Neumann, Emily, Neves, Bernardo, Ng, Pauline Yeung, Ng, Wing Yiu, Nghi, Anthony, Ngure, Jane, Nguyen, Duc, Choileain, Orna Ni, Leathlobhair, Niamh Ni, Nichol, Alistair, Nitayavardhana, Prompak, Nonas, Stephanie, Noordin, Nurul Amani Mohd, Noret, Marion, Norharizam, Nurul Faten Izzati, Norman, Lisa, Notari, Alessandra, Noursadeghi, Mahdad, Nowicka, Karolina, Nowinski, Adam, Nseir, Saad, Nunez, Jose I., Nurnaningsih, Nurnaningsih, Nusantara, Dwi Utomo, Nyamankolly, Elsa, Nygaard, Anders Benteson, Brien, Fionnuala O., Callaghan, Annmarie O., O’Callaghan, Annmarie, O’Donnell, Max, O’Halloran, Sophie, O’Hearn, Katie, O’Neil, Conar, O’Shea, Linda, O’Sullivan, Miriam, Occhipinti, Giovanna, OConnor, Derbrenn, Ogston, Tawnya, Ogura, Takayuki, Oh, Tak-Hyuk, Ohshimo, Shinichiro, Oldakowska, Agnieszka, Oliveira, João, Oliveira, Larissa, Olliaro, Piero L., Ong, David S. Y., Ong, Jee Yan, Oosthuyzen, Wilna, Opavsky, Anne, Openshaw, Peter, Orakzai, Saijad, Orozco-Chamorro, Claudia Milena, Orquera, Andrés, Ortoleva, Jamel, Osatnik, Javier, Othman, Siti Zubaidah, Otiku, Paul, Ouamara, Nadia, Ouissa, Rachida, Owyang, Clark, Oziol, Eric, Pagadoy, Maïder, Pages, Justine, Palacios, Amanda, Palacios, Mario, Palmarini, Massimo, Panarello, Giovanna, Panda, Prasan Kumar, Paneru, Hem, Pang, Lai Hui, Panigada, Mauro, Pansu, Nathalie, Papadopoulos, Aurélie, Parducci, Paolo, Oña, Edwin Fernando Paredes, Parke, Rachael, Parker, Melissa, Parra, Briseida, Parrini, Vieri, Pasha, Taha, Pasquier, Jérémie, Pastene, Bruno, Patauner, Fabian, Patel, Drashti, Pathmanathan, Mohan Dass, Patrão, Luís, Patricio, Patricia, Patrier, Juliette, Patrizi, Laura, Patterson, Lisa, Pattnaik, Rajyabardhan, Paul, Christelle, Paul, Mical, Paulos, Jorge, Paxton, William A., Payen, Jean-François, Peariasamy, Kalaiarasu, Jiménez, Miguel Pedrera, Peek, Giles J., Peelman, Florent, Peiffer-Smadja, Nathan, Peigne, Vincent, Pejkovska, Mare, Pelosi, Paolo, Peltan, Ithan D., Pereira, Rui, Perez, Daniel, Periel, Luis, Perpoint, Thomas, Pesenti, Antonio, Pestre, Vincent, Petrou, Lenka, Petrov-Sanchez, Ventzislava, Petrovic, Michele, Pettersen, Frank Olav, Peytavin, Gilles, Pharand, Scott, Phonemixay, Ooyanong, Piagnerelli, Michael, Picard, Walter, Picone, Olivier, de Piero, Maria, Pierobon, Carola, Piersma, Djura, Pimentel, Carlos, Pinto, Raquel, Pires, Catarina, Pironneau, Isabelle, Piroth, Lionel, Pisi, Roberta, Pitaloka, Ayodhia, Pius, Riinu, Piva, Simone, Plantier, Laurent, Png, Hon Shen, Poissy, Julien, Pokeerbux, Ryadh, Pokorska-Spiewak, Maria, Poli, Sergio, Pollakis, Georgios, Ponscarme, Diane, Popielska, Jolanta, Porto, Diego Bastos, Post, Andra-Maris, Postma, Douwe F., Povoa, Pedro, Póvoas, Diana, Powis, Jeff, Prapa, Sofia, Praphasiri, Viladeth, Preau, Sébastien, Prebensen, Christian, Preiser, Jean-Charles, Prinssen, Anton, Pritchard, Mark G., Priyadarshani, Gamage Dona Dilanthi, Proença, Lucia, Pudota, Sravya, Puéchal, Oriane, Semedi, Bambang Pujo, Pulicken, Mathew, Puntoni, Matteo, Purcell, Gregory, Quesada, Luisa, Quinones-Cardona, Vilmaris, González, Víctor Quirós, Quist-Paulsen, Else, Quraishi, Mohammed, Rabaa, Maia, Rabaud, Christian, Rabindrarajan, Ebenezer, Rafael, Aldo, Rafiq, Marie, Ragazzo, Gabrielle, Rahardjani, Mutia, Ab Rahman, Ahmad Kashfi Haji, Rahman, Rozanah Abd, Rahutullah, Arsalan, Rainieri, Fernando, Rajahram, Giri Shan, Ramachandran, Pratheema, Ramakrishnan, Nagarajan, Ramanathan, Kollengode, Ramli, Ahmad Afiq, Rammaert, Blandine, Ramos, Grazielle Viana, Rampello, Anais, Rana, Asim, Rangappa, Rajavardhan, Ranjan, Ritika, Ranza, Elena, Rapp, Christophe, Rashan, Aasiyah, Rashan, Thalha, Rasheed, Ghulam, Rasmin, Menaldi, Rätsep, Indrek, Rau, Cornelius, Rausa, Francesco, Ravi, Tharmini, Raza, Ali, Real, Andre, Rebaudet, Stanislas, Redl, Sarah, Reeve, Brenda, Rehman, Attaur, Reid, Liadain, Reikvam, Dag Henrik, Reis, Renato, Rello, Jordi, Remppis, Jonathan, Remy, Martine, Ren, Hongru, Renk, Hanna, Resseguier, Anne-Sophie, Revest, Matthieu, Rewa, Oleksa, Reyes, Luis Felipe, Reyes, Tiago, Ribeiro, Maria Ines, Ricchiuto, Antonia, Richardson, David, Richardson, Denise, Richier, Laurent, Ridzuan, Siti Nurul Atikah Ahmad, Riera, Jordi, Rios, Ana L., Rishu, Asgar, Rispal, Patrick, Risso, Karine, Nuñez, Maria Angelica Rivera, Rizer, Nicholas, Robba, Chiara, Roberto, André, Roberts, Stephanie, Robertson, David L., Robineau, Olivier, Roche-Campo, Ferran, Rodari, Paola, Rodeia, Simão, Abreu, Julia Rodriguez, Roessler, Bernhard, Roger, Claire, Roger, Pierre-Marie, Roilides, Emmanuel, Rojek, Amanda, Romaru, Juliette, Roncon-Albuquerque Jr, Roberto, Roriz, Mélanie, Rosa-Calatrava, Manuel, Rose, Michael, Rosenberger, Dorothea, Roslan, Nurul Hidayah Mohammad, Rossanese, Andrea, Rossetti, Matteo, Rossi, Sandra, Rossignol, Bénédicte, Rossignol, Patrick, Rousset, Stella, Roy, Carine, Roze, Benoît, Rusmawatiningtyas, Desy, Russell, Clark D., Ryan, Maeve, Ryan, Maria, Ryckaert, Mazankowski Heart Institute, Ryckaert, Steffi, Holten, Aleksander Rygh, Saba, Isabela, Sacchelli, Luca, Sadaf, Sairah, Sadat, Musharaf, Sahraei, Valla, Saidani, Nadia, Saint-Gilles, Maximilien, Sakiyalak, Pranya, Salahuddin, Nawal, Salazar, Leonardo, Saleem, Jodat, Saleh, Nazal, Sales, Gabriele, Sallaberry, Stéphane, Gandonniere, Charlotte Salmon, Salvator, Hélène, Sanchez, Olivier, Choez, Xavier Sánchez, de Oliveira, Kizy Sanchez, Sanchez-Miralles, Angel, Sancho-Shimizu, Vanessa, Sandhu, Gyan, Sandhu, Zulfiqar, Sandrine, Pierre-François, Sandulescu, Oana, Santos, Marlene, Sarfo-Mensah, Shirley, Banheiro, Bruno Sarmento, Sarmiento, Iam Claire E., Sarton, Benjamine, Satya, Ankana, Satyapriya, Sree, Satyawati, Rumaisah, Saviciute, Egle, Savvidou, Parthena, Saw, Yen Tsen, Schaffer, Justin, Schermer, Tjard, Scherpereel, Arnaud, Schneider, Marion, Schroll, Stephan, Schwameis, Michael, Schwartz, Gary, Scott, Janet T., Scott-Brown, James, Sedillot, Nicholas, Seitz, Tamara, Selvanayagam, Jaganathan, Selvarajoo, Mageswari, Semaille, Caroline, Semple, Malcolm G., Senian, Rasidah Bt, Senneville, Eric, Sepulveda, Claudia, Sequeira, Filipa, Sequeira, Tânia, Neto, Ary Serpa, Balazote, Pablo Serrano, Shadowitz, Ellen, Shahidan, Syamin Asyraf, Shamsah, Mohammad, Shankar, Anuraj, Sharjeel, Shaikh, Sharma, Pratima, Shaw, Catherine A., Shaw, Victoria, Sheharyar, Ashraf, Shetty, Dr. Rajesh Mohan, Shetty, Rohan, Shi, Haixia, Shiban, Nisreen, Shiekh, Mohiuddin, Shiga, Takuya, Shime, Nobuaki, Shimizu, Hiroaki, Shimizu, Keiki, Shimizu, Naoki, Shrapnel, Sally, Shrestha, Pramesh Sundar, Shrestha, Shubha Kalyan, Shum, Hoi Ping, Mohammed, Nassima Si, Siang, Ng Yong, Sibiude, Jeanne, Sibounheuang, Bountoy, Siddiqui, Atif, Sigfrid, Louise, Sillaots, Piret, Silva, Catarina, Silva, Maria Joao, Silva, Rogério, Heng, Benedict Sim Lim, Sin, Wai Ching, Sinatti, Dario, Singh, Budha Charan, Singh, Punam, Sitompul, Pompini Agustina, Sivam, Karisha, Skogen, Vegard, Smith, Sue, Smood, Benjamin, Smyth, Coilin, Smyth, Michelle, Snacken, Morgane, So, Dominic, Soh, Tze Vee, Solberg, Lene Bergendal, Solomon, Joshua, Solomon, Tom, Somers, Emily, Sommet, Agnès, Song, Myung Jin, Song, Rima, Song, Tae, Chia, Jack Song, Sonntagbauer, Michael, Soom, Azlan Mat, Søraas, Arne, Søraas, Camilla Lund, Sotto, Alberto, Soum, Edouard, Sousa, Ana Chora, Sousa, Marta, Uva, Maria Sousa, Souza-Dantas, Vicente, Sperry, Alexandra, Spinuzza, Elisabetta, Darshana, B. P. Sanka Ruwan Sri, Sriskandan, Shiranee, Stabler, Sarah, Staudinger, Thomas, Stecher, Stephanie-Susanne, Steinsvik, Trude, Stienstra, Ymkje, Stiksrud, Birgitte, Stolz, Eva, Stone, Amy, Streinu-Cercel, Adrian, Streinu-Cercel, Anca, Strudwick, Samantha, Stuart, Ami, Stuart, David, Subekti, Decy, Suen, Gabriel, Suen, Jacky Y., Sultana, Asfia, Summers, Charlotte, Supic, Dubravka, Suppiah, Deepashankari, Surovcová, Magdalena, Suwarti, Suwarti, Svistunov, Andrey A., Syahrin, Sarah, Syrigos, Konstantinos, Sztajnbok, Jaques, Szuldrzynski, Konstanty, Tabrizi, Shirin, Taccone, Fabio S., Tagherset, Lysa, Taib, Shahdattul Mawarni, Talarek, Ewa, Taleb, Sara, Talsma, Jelmer, Tamisier, Renaud, Tampubolon, Maria Lawrensia, Tan, Kim Keat, Tan, Le Van, Tan, Yan Chyi, Tanaka, Clarice, Tanaka, Hiroyuki, Tanaka, Taku, Taniguchi, Hayato, Taqdees, Huda, Taqi, Arshad, Tardivon, Coralie, Tattevin, Pierre, Taufik, M Azhari, Tawfik, Hassan, Tedder, Richard S., Tee, Tze Yuan, Teixeira, João, Tejada, Sofia, Tellier, Marie-Capucine, Teoh, Sze Kye, Teotonio, Vanessa, Téoulé, François, Terpstra, Pleun, Terrier, Olivier, Terzi, Nicolas, Tessier-Grenier, Hubert, Tey, Adrian, Thabit, Alif Adlan Mohd, Thakur, Anand, Tham, Zhang Duan, Thangavelu, Suvintheran, Thibault, Vincent, Thiberville, Simon-Djamel, Thill, Benoît, Thirumanickam, Jananee, Thompson, Shaun, Thomson, David, Thomson, Emma C., Thurai, Surain Raaj Thanga, Thuy, Duong Bich, Thwaites, Ryan S., Ticinesi, Andrea, Tierney, Paul, Tieroshyn, Vadim, Timashev, Peter S., Timsit, Jean-François, Vijayaraghavan, Bharath Kumar Tirupakuzhi, Tissot, Noémie, Toh, Jordan Zhien Yang, Toki, Maria, Tonby, Kristian, Tonnii, Sia Loong, Torres, Antoni, Torres, Margarida, Santos-Olmo, Rosario Maria Torres, Torres-Zevallos, Hernando, Towers, Michael, Trapani, Tony, Treoux, Théo, Trieu, Huynh Trung, Tromeur, Cécile, Trontzas, Ioannis, Trouillon, Tiffany, Truong, Jeanne, Tual, Christelle, Tubiana, Sarah, Tuite, Helen, Turmel, Jean-Marie, Turtle, Lance C. W., Tveita, Anders, Twardowski, Pawel, Uchiyama, Makoto, Udayanga, P G Ishara, Udy, Andrew, Ullrich, Roman, Uribe, Alberto, Usman, Asad, Uyeki, Timothy M., Vajdovics, Cristinava, Val-Flores, Luís, Valentini, Piero, Valle, Ana Luiza, Valran, Amélie, Valzano, Ilaria, Van de Velde, Stijn, van den Berge, Marcel, Van der Feltz, Machteld, van der Palen, Job, van der Valk, Paul, Van Der Vekens, Nicky, Van der Voort, Peter, Van Der Werf, Sylvie, van Dyk, Marlice, van Gulik, Laura, Van Hattem, Jarne, van Netten, Carolien, Van Twillert, Gitte, van Veen, Ilonka, Vanel, Noémie, Vanoverschelde, Henk, Varghese, Pooja, Varrone, Michael, Vasudayan, Shoban Raj, Vauchy, Charline, Veeran, Shaminee, Veislinger, Aurélie, Vencken, Sebastian, Ventura, Sara, Verbon, Annelies, Vickers, James, Vidal, José Ernesto, Vieira, César, Vijayan, Deepak, Villanueva, Joy Ann, Villar, Judit, Villeneuve, Pierre-Marc, Villoldo, Andrea, Van Vinh Chau, Nguyen, Vishwanathan, Gayatri, Visseaux, Benoit, Visser, Hannah, Vitiello, Chiara, Vongsouvath, Manivanh, Vonkeman, Harald, Vuotto, Fanny, Wahab, Noor Hidayu, Wahab, Suhaila Abdul, Wahid, Nadirah Abdul, Wainstein, Marina, Shukeri, Wan Fadzlina Wan Muhd, Wang, Chih-Hsien, Webb, Steve, Wei, Jia, Weil, Katharina, Wen, Tan Pei, Wesselius, Sanne, West, T. Eoin, Wham, Murray, Whelan, Bryan, White, Nicole, Wicky, Paul Henri, Wiedemann, Aurélie, Wijaya, Surya Otto, Wille, Keith, Willems, Suzette, Williams, Virginie, Wils, Evert-Jan, Wong, Calvin, Wong, Teck Fung, Wong, Xin Ci, Wong, Yew Sing, Wright, Natalie, Xian, Gan Ee, Xian, Lim Saio, Xuan, Kuan Pei, Xynogalas, Ioannis, Yacoub, Sophie, Yakop, Siti Rohani Binti Mohd, Yamazaki, Masaki, Yazdanpanah, Yazdan, Hing, Nicholas Yee Liang, Yelnik, Cécile, Yeoh, Chian Hui, Yerkovich, Stephanie, Yiaye, Touxiong, Yokoyama, Toshiki, Yonis, Hodane, Yousif, Obada, Yuliarto, Saptadi, Zaaqoq, Akram, Zabbe, Marion, Zacharowski, Kai, Zahid, Masliza, Zahran, Maram, Zaidan, Nor Zaila Binti, Zambon, Maria, Zambrano, Miguel, Zanella, Alberto, Zawadka, Konrad, Zaynah, Nurul, Zayyad, Hiba, Zoufaly, Alexander, Zucman, David, Fryer, Daniel Vidali, Duque, Sara, Fuentes, Yuli V., Baruch, Joaquin, Beane, Abi, Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), University of La Sabana = Universitad de la Sabana, University of Queensland [Brisbane], University of British Columbia (UBC), University of Oxford, The investigators acknowledge: This work is part of the Grand Challenges ICODA pilot initiative, delivered by Health Data Research UK and funded by the Bill & Melinda Gates Foundation and the Minderoo Foundation. The philanthropic support of the donors to the University of Oxford’s COVID-19 Research Response Fund, UK Foreign, Commonwealth and Development Office and Wellcome [215091/Z/18/Z and 220757/Z/20/Z], the Bill & Melinda Gates Foundation [OPP1209135], the National Institute for Health Research (NIHR, award CO-CIN-01), the Medical Research Council (MRC, grant MC_PC_19059), the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with Public Health England (PHE)(award 200907), NIHR HPRU in Respiratory Infections at Imperial College London with PHE (award 200927), Liverpool Experimental Cancer Medicine Centre (grant C18616/A25153), NIHR Biomedical Research Centre at Imperial College London (award IS-BRC-1215-20013), NIHR Clinical Research Network (infrastructure support), CIHR Coronavirus Rapid Research Funding Opportunity OV2170359 and was coordinated out of Sunnybrook Research Institute, the endorsement of the Irish Critical Care- Clinical Trials Group, co-ordinated in Ireland by the Irish Critical Care- Clinical Trials Network at University College Dublin and funded by the Health Research Board of Ireland [CTN-2014-12], Rapid European COVID-19 Emergency Response research (RECOVER) [H2020 project 101003589], European Clinical Research Alliance on Infectious Diseases (ECRAID) [965313], COVID clinical management team, AIIMS, Rishikesh, India, Cambridge NIHR Biomedical Research Centre, the dedication and hard work of the Groote Schuur Hospital Covid ICU Team, the Groote Schuur nursing and University of Cape Town registrar bodies coordinated by the Division of Critical Care at the University of Cape Town, Wellcome Trust fellowship [205228/Z/16/Z], the Liverpool School of Tropical Medicine, the University of Oxford, the dedication and hard work of the Norwegian SARS-CoV-2 study team, the Research Council of Norway grant no 312780, a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner, Innovative Medicines Initiative Joint Undertaking under Grant Agreement No. 115523 COMBACTE, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007–2013) and EFPIA companies, in-kind contribution, preparedness work conducted by the Short Period Incidence Study of Severe Acute Respiratory Infection, Stiftungsfonds zur Förderung der Bekämpfung der Tuberkulose und anderer Lungenkrankheiten of the City of Vienna, Project Number: APCOV22BGM, Italian Ministry of Health 'Fondi Ricerca corrente–L1P6' to IRCCS Ospedale Sacro Cuore–Don Calabria, Australian Department of Health grant (3273191), Gender Equity Strategic Fund at University of Queensland, Artificial Intelligence for Pandemics (A14PAN) at University of Queensland, the Australian Research Council Centre of Excellence for Engineered Quantum Systems (EQUS, CE170100009), the Prince Charles Hospital Foundation, Australia, UK Medical Research Council Clinical Research Training Fellowship MR/V001671/1, Instituto de Salud Carlos III, Ministerio de Ciencia, Spain, Brazil, National Council for Scientific and Technological Development Scholarship number 303953/2018-7, Firland Foundation, Shoreline, Washington, USA, the French COVID cohort (NCT04262921) is sponsored by INSERM and is funding by the REACTing (REsearch & ACtion emergING infectious diseases) consortium and by a grant of the French Ministry of Health (PHRC n°20-0424). This work uses Data/Material provided by patients and collected by the NHS as part of their care and support #DataSavesLives. The Data/materials used for this research were obtained from ISARIC4C. ISARIC4C Investigators collated the COVID-19 Clinical Information Network (CO-CIN) data., European Project: 101003589, H2020-SC1-PHE-CORONAVIRUS-2020,RECOVER(2020), Bill & Melinda Gates Foundation, Minderoo Foundation, Commonwealth Foundation, Wellcome Trust, National Institute for Health Research (UK), Medical Research Council (UK), University of Liverpool, Imperial College London, Canadian Institutes of Health Research, Sunnybrook Research Institute, Health Research Board (Ireland), European Commission, All India Institute of Medical Science, University of Cape Town, Research Council of Norway, Innovative Medicines Initiative, Governo Italiano, University of Queensland, Australian Research Council, Prince Charles Hospital Foundation, Instituto de Salud Carlos III, Institut National de la Santé et de la Recherche Médicale (France), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Garcia-Gallo, Esteban, Merson, Laura, Kennon, Kalynn, Kelly, Sadie, Citarella, Barbara Wanjiru, Fryer, Daniel Vidali, Shrapnel, Sally, Lee, Jame, Duque, Sara, Fuentes, Yuli V, Balan, Valeria, Smith, Sue, Wei, Jia, Gonçalves, Bronner P, Russell, Clark D, Sigfrid, Louise, Dagens, Andrew, Olliaro, Piero L, Baruch, Joaquin, Kartsonaki, Christiana, Dunning, Jake, Rojek, Amanda, Rashan, Aasiyah, Beane, Abi, Murthy, Sriniva, Reyes, Luis Felipe, ISARIC Clinical Characterization Group: Ali Abbas, Sheryl Ann Abdukahil, Nurul Najmee Abdulkadir, Ryuzo Abe, Laurent Abel, Lara Absil, Kamal Abu Jabal, Hiba Abu Zayyad, Subhash Acharya, Andrew Acker, Shingo Adachi, Elisabeth Adam, Enrico Adriano, Diana Adrião, Saleh Al Ageel, Shakeel Ahmed, Marina Aiello, Kate Ainscough, Eka Airlangga, Tharwat Aisa, Ali Ait Hssain, Younes Ait Tamlihat, Takako Akimoto, Ernita Akmal, Eman Al Qasim, Tala Al-Dabbous, Abdulrahman Al-Fares, Razi Alalqam, Angela Alberti, Senthilkumar Alegesan, Cynthia Alegre, Marta Alessi, Beatrice Alex, Kévin Alexandre, Huda Alfoudri, Adam Ali, Imran Ali, Naseem Ali Shah, Naseem Ali Sheikh, Kazali Enagnon Alidjnou, Jeffrey Aliudin, Qabas Alkhafajee, Clotilde Allavena, Nathalie Allou, Aneela Altaf, João Alves, João Melo Alves, Rita Alves, Maria Amaral, Nur Amira, Heidi Ammerlaan, Phoebe Ampaw, Roberto Andini, Claire Andrejak, Andrea Angheben, François Angoulvant, Séverine Ansart, Sivanesen Anthonidass, Massimo Antonelli, Carlos Alexandre Antunes de Brito, Kazi Rubayet Anwar, Ardiyan Apriyana, Yaseen Arabi, Irene Aragao, Francisco Arancibia, Carolline Araujo, Antonio Arcadipane, Patrick Archambault, Lukas Arenz, Jean-Benoît Arlet, Christel Arnold-Day, Ana Aroca, Lovkesh Arora, Rakesh Arora, Elise Artaud-Macari, Diptesh Aryal, Motohiro Asaki, Angel Asensio, Elizabeth Ashley, Muhammad Ashraf, Namra Asif, Mohammad Asim, Jean Baptiste Assie, Amirul Asyraf, Anika Atique, A M Udara Lakshan Attanyake, Johann Auchabie, Hugues Aumaitre, Adrien Auvet, Eyvind W Axelsen, Laurène Azemar, Cecile Azoulay, Benjamin Bach, Delphine Bachelet, Claudine Badr, Roar Bævre-Jensen, Nadia Baig, J Kenneth Baillie, J Kevin Baird, Erica Bak, Agamemnon Bakakos, Nazreen Abu Bakar, Andriy Bal, Mohanaprasanth Balakrishnan, Valeria Balan, Firouzé Bani-Sadr, Renata Barbalho, Nicholas Yuri Barbosa, Wendy S Barclay, Saef Umar Barnett, Michaela Barnikel, Helena Barrasa, Audrey Barrelet, Cleide Barrigoto, Marie Bartoli, Cheryl Bartone, Joaquín Baruch, Mustehan Bashir, Romain Basmaci, Muhammad Fadhli Hassin Basri, Denise Battaglini, Jules Bauer, Diego Fernando Bautista Rincon, Denisse Bazan Dow, Abigail Beane, Alexandra Bedossa, Ker Hong Bee, Husna Begum, Sylvie Behilill, Karine Beiruti, Albertus Beishuizen, Aleksandr Beljantsev, David Bellemare, Anna Beltrame, Beatriz Amorim Beltrão, Marine Beluze, Nicolas Benech, Lionel Eric Benjiman, Dehbia Benkerrou, Suzanne Bennett, Luís Bento, Jan-Erik Berdal, Delphine Bergeaud, Hazel Bergin, José Luis Bernal Sobrino, Giulia Bertoli, Lorenzo Bertolino, Simon Bessis, Adam Betz, Sybille Bevilcaqua, Karine Bezulier, Amar Bhatt, Krishna Bhavsar, Isabella Bianchi, Claudia Bianco, Farah Nadiah Bidin, Moirangthem Bikram Singh, Felwa Bin Humaid, Mohd Nazlin Bin Kamarudin, François Bissuel, Patrick Biston, Laurent Bitker, Jonathan Bitton, Pablo Blanco-Schweizer, Catherine Blier, Frank Bloos, Mathieu Blot, Lucille Blumberg, Filomena Boccia, Laetitia Bodenes, Alice Bogaarts, Debby Bogaert, Anne-Hélène Boivin, Pierre-Adrien Bolze, François Bompart, Patrizia Bonelli, Aurelius Bonfasius, Diogo Borges, Raphaël Borie, Hans Martin Bosse, Elisabeth Botelho-Nevers, Lila Bouadma, Olivier Bouchaud, Sabelline Bouchez, Dounia Bouhmani, Damien Bouhour, Kévin Bouiller, Laurence Bouillet, Camile Bouisse, Thipsavanh Bounphiengsy, Latsaniphone Bountthasavong, Anne-Sophie Boureau, John Bourke, Maude Bouscambert, Aurore Bousquet, Jason Bouziotis, Bianca Boxma, Marielle Boyer-Besseyre, Maria Boylan, Fernando Augusto Bozza, Axelle Braconnier, Cynthia Braga, Timo Brandenburger, Filipa Brás Monteiro, Luca Brazzi, Dorothy Breen, Patrick Breen, Kathy Brickell, Alex Browne, Shaunagh Browne, Nicolas Brozzi, Sonja Hjellegjerde Brunvoll, Marjolein Brusse-Keizer, Nina Buchtele, Christian Buesaquillo, Polina Bugaeva, Marielle Buisson, Danilo Buonsenso, Erlina Burhan, Aidan Burrell, Ingrid G Bustos, Denis Butnaru, André Cabie, Susana Cabral, Eder Caceres, Cyril Cadoz, Mia Callahan, Kate Calligy, Jose Andres Calvache, Caterina Caminiti, João Camões, Valentine Campana, Paul Campbell, Josie Campisi, Cecilia Canepa, Mireia Cantero, Pauline Caraux-Paz, Sheila Cárcel, Chiara Simona Cardellino, Filipa Cardoso, Filipe Cardoso, Nelson Cardoso, Sofia Cardoso, Simone Carelli, Francesca Carlacci, Nicolas Carlier, Thierry Carmoi, Gayle Carney, Inês Carqueja, Marie-Christine Carret, François Martin Carrier, Ida Carroll, Gail Carson, Leonor Carvalho, Maire-Laure Casanova, Mariana Cascão, Siobhan Casey, José Casimiro, Bailey Cassandra, Silvia Castañeda, Nidyanara Castanheira, Guylaine Castor-Alexandre, Henry Castrillón, Ivo Castro, Ana Catarino, François-Xavier Catherine, Paolo Cattaneo, Roberta Cavalin, Giulio Giovanni Cavalli, Alexandros Cavayas, Adrian Ceccato, Minerva Cervantes-Gonzalez, Anissa Chair, Catherine Chakveatze, Adrienne Chan, Meera Chand, Christelle Chantalat Auger, Jean-Marc Chapplain, Julie Chas, Allegra Chatterjee, Mobin Chaudry, Jonathan Samuel Chávez Iñiguez, Anjellica Chen, Yih-Sharng Chen, Matthew Pellan Cheng, Antoine Cheret, Alfredo Antonio Chetta, Thibault Chiarabini, Julian Chica, Suresh Kumar Chidambaram, Leong Chin Tho, Catherine Chirouze, Davide Chiumello, Hwa Jin Cho, Sung-Min Cho, Bernard Cholley, Danoy Chommanam, Marie-Charlotte Chopin, Ting Soo Chow, Yock Ping Chow, Nathaniel Christy, Hiu Jian Chua, Jonathan Chua, Jose Pedro Cidade, José Miguel Cisneros Herreros, Barbara Wanjiru Citarella, Anna Ciullo, Emma Clarke, Jennifer Clarke, Rolando Claure-Del Granado, Sara Clohisey, Perren J Cobb, Cassidy Codan, Caitriona Cody, Alexandra Coelho, Megan Coles, Gwenhaël Colin, Michael Collins, Sebastiano Maria Colombo, Pamela Combs, Marie Connor, Anne Conrad, Sofía Contreras, Elaine Conway, Graham S Cooke, Mary Copland, Hugues Cordel, Amanda Corley, Sabine Cornelis, Alexander Daniel Cornet, Arianne Joy Corpuz, Andrea Cortegiani, Grégory Corvaisier, Emma Costigan, Camille Couffignal, Sandrine Couffin-Cadiergues, Roxane Courtois, Stéphanie Cousse, Rachel Cregan, Charles Crepy D'Orleans, Sabine Croonen, Gloria Crowl, Jonathan Crump, Claudina Cruz, Juan Luis Cruz Berm, Jaime Cruz Rojo, Marc Csete, Alberto Cucino, Ailbhe Cullen, Matthew Cummings, Ger Curley, Gerard Curley, Elodie Curlier, Colleen Curran, Paula Custodio, Federico D'Amico, Frédérick D'Aragon, Eric D'Ortenzio, Ana da Silva Filipe, Charlene Da Silveira, Al-Awwab Dabaliz, Andrew Dagens, John Arne Dahl, Darren Dahly, Heidi Dalton, Jo Dalton, Seamus Daly, Nick Daneman, Corinne Daniel, Emmanuelle A Dankwa, Jorge Dantas, Mark de Boer, Gillian de Loughry, Diego de Mendoza, Etienne De Montmollin, Rafael Freitas de Oliveira França, Ana Isabel de Pinho Oliveira, Rosanna De Rosa, Cristina De Rose, Thushan de Silva, Peter de Vries, Jillian Deacon, David Dean, Alexa Debard, Bianca DeBenedictis, Marie-Pierre Debray, Nathalie DeCastro, William Dechert, Lauren Deconninck, Romain Decours, Eve Defous, Isabelle Delacroix, Eric Delaveuve, Karen Delavigne, Nathalie M Delfos, Ionna Deligiannis, Andrea Dell'Amore, Christelle Delmas, Pierre Delobel, Corine Delsing, Elisa Demonchy, Emmanuelle Denis, Dominique Deplanque, Pieter Depuydt, Mehul Desai, Diane Descamps, Mathilde Desvallées, Santi Dewayanti, Pathik Dhanger, Alpha Diallo, Sylvain Diamantis, André Dias, Andrea Dias, Juan Jose Diaz, Priscila Diaz, Rodrigo Diaz, Kévin Didier, Jean-Luc Diehl, Wim Dieperink, Jérôme Dimet, Vincent Dinot, Fara Diop, Alphonsine Diouf, Yael Dishon, Félix Djossou, Annemarie B Docherty, Helen Doherty, Arjen M Dondorp, Andy Dong, Christl A Donnelly, Maria Donnelly, Chloe Donohue, Sean Donohue, Yoann Donohue, Peter Doran, Céline Dorival, Phouvieng Douangdala, James Joshua Douglas, Renee Douma, Nathalie Dournon, Triona Downer, Joanne Downey, Mark Downing, Tom Drake, Aoife Driscoll, Amiel A Dror, Murray Dryden, Claudio Duarte Fonseca, Vincent Dubee, François Dubos, Audrey Dubot-Pérès, Alexandre Ducancelle, Toni Duculan, Susanne Dudman, Abhijit Duggal, Paul Dunand, Jake Dunning, Mathilde Duplaix, Emanuele Durante-Mangoni, Lucian Durham 3rd, Bertrand Dussol, Juliette Duthoit, Xavier Duval, Anne Margarita Dyrhol-Riise, Sim Choon Ean, Marco Echeverria-Villalobos, Giorgio Economopoulos, Michael Edelstein, Siobhan Egan, Linn Margrete Eggesbø, Carla Eira, Mohammed El Sanharawi, Subbarao Elapavaluru, Brigitte Elharrar, Jacobien Ellerbroek, Merete Ellingjord-Dale, Philippine Eloy, Tarek Elshazly, Iqbal Elyazar, Isabelle Enderle, Tomoyuki Endo, Chan Chee Eng, Ilka Engelmann, Vincent Enouf, Olivier Epaulard, Martina Escher, Mariano Esperatti, Hélène Esperou, Marina Esposito-Farese, João Estevão, Manuel Etienne, Nadia Ettalhaoui, Anna Greti Everding, Mirjam Evers, Isabelle Fabre, Marc Fabre, Amna Faheem, Arabella Fahy, Cameron J Fairfield, Zul Fakar, Komal Fareed, Pedro Faria, Ahmed Farooq, Hanan Fateena, Arie Zainul Fatoni, Karine Faure, Raphaël Favory, Mohamed Fayed, Niamh Feely, Laura Feeney, Jorge Fernandes, Marília Andreia Fernandes, Susana Fernandes, François-Xavier Ferrand, Eglantine Ferrand Devouge, Joana Ferrão, Carlo Ferrari, Mário Ferraz, Benigno Ferreira, Isabel Ferreira, Sílvia Ferreira, Ricard Ferrer-Roca, Nicolas Ferriere, Céline Ficko, Claudia Figueiredo-Mello, William Finlayson, Juan Fiorda, Thomas Flament, Clara Flateau, Tom Fletcher, Letizia Lucia Florio, Brigid Flynn, Deirdre Flynn, Federica Fogliazza, Claire Foley, Jean Foley, Victor Fomin, Tatiana Fonseca, Patricia Fontela, Simon Forsyth, Denise Foster, Giuseppe Foti, Erwan Fourn, Robert A Fowler, Marianne Fraher, Diego Franch-Llasat, Christophe Fraser, John F Fraser, Marcela Vieira Freire, Ana Freitas Ribeiro, Craig French, Caren Friedrich, Ricardo Fritz, Stéphanie Fry, Nora Fuentes, Masahiro Fukuda, G Argin, Valérie Gaborieau, Rostane Gaci, Massimo Gagliardi, Jean-Charles Gagnard, Nathalie Gagné, Amandine Gagneux-Brunon, Sérgio Gaião, Linda Gail Skeie, Phil Gallagher, Elena Gallego Curto, Carrol Gamble, Yasmin Gani, Arthur Garan, Rebekha Garcia, Noelia García Barrio, Julia Garcia-Diaz, Esteban Garcia-Gallo, Navya Garimella, Federica Garofalo, Denis Garot, Valérie Garrait, Basanta Gauli, Nathalie Gault, Aisling Gavin, Anatoliy Gavrylov, Alexandre Gaymard, Johannes Gebauer, Eva Geraud, Louis Gerbaud Morlaes, Nuno Germano, Praveen Kumar Ghisulal, Jade Ghosn, Marco Giani, Carlo Giaquinto, Jess Gibson, Tristan Gigante, Morgane Gilg, Elaine Gilroy, Guillermo Giordano, Michelle Girvan, Valérie Gissot, Jesse Gitaka, Gezy Giwangkancana, Daniel Glikman, Petr Glybochko, Eric Gnall, Geraldine Goco, François Goehringer, Siri Goepel, Jean-Christophe Goffard, Jin Yi Goh, Jonathan Golob, Rui Gomes, Kyle Gomez, Joan Gómez-Junyent, Marie Gominet, Bronner P Gonçalves, Alicia Gonzalez, Patricia Gordon, Yanay Gorelik, Isabelle Gorenne, Laure Goubert, Cécile Goujard, Tiphaine Goulenok, Margarite Grable, Jeronimo Graf, Edward Wilson Grandin, Pascal Granier, Giacomo Grasselli, Lorenzo Grazioli, Christopher A Green, Courtney Greene, William Greenhalf, Segolène Greffe, Domenico Luca Grieco, Matthew Griffee, Fiona Griffiths, Ioana Grigoras, Albert Groenendijk, Anja Grosse Lordemann, Heidi Gruner, Yusing Gu, Fabio Guarracino, Jérémie Guedj, Martin Guego, Dewi Guellec, Anne-Marie Guerguerian, Daniela Guerreiro, Romain Guery, Anne Guillaumot, Laurent Guilleminault, Maisa Guimarães de Castro, Thomas Guimard, Marieke Haalboom, Daniel Haber, Hannah Habraken, Ali Hachemi, Amy Hackmann, Nadir Hadri, Fakhir Haidri, Sheeba Hakak, Adam Hall, Matthew Hall, Sophie Halpin, Jawad Hameed, Ansley Hamer, Raph L Hamers, Rebecca Hamidfar, Bato Hammarström, Terese Hammond, Lim Yuen Han, Rashan Haniffa, Kok Wei Hao, Hayley Hardwick, Ewen M Harrison, Janet Harrison, Samuel Bernard Ekow Harrison, Alan Hartman, Mohd Shahnaz Hasan, Junaid Hashmi, Madiha Hashmi, Ailbhe Hayes, Leanne Hays, Jan Heerman, Lars Heggelund, Ross Hendry, Martina Hennessy, Aquiles Henriquez-Trujillo, Maxime Hentzien, Jaime Hernandez-Montfort, Daniel Herr, Andrew Hershey, Liv Hesstvedt, Astarini Hidayah, Dawn Higgins, Eibhilin Higgins, Rita Hinchion, Samuel Hinton, Hiroaki Hiraiwa, Haider Hirkani, Hikombo Hitoto, Antonia Ho, Yi Bin Ho, Alexandre Hoctin, Isabelle Hoffmann, Wei Han Hoh, Oscar Hoiting, Rebecca Holt, Jan Cato Holter, Peter Horby, Juan Pablo Horcajada, Koji Hoshino, Kota Hoshino, Ikram Houas, Catherine L Hough, Stuart Houltham, Jimmy Ming-Yang Hsu, Jean-Sébastien Hulot, Stella Huo, Iqbal Hussain, Samreen Ijaz, Hajnal-Gabriela Illes, Patrick Imbert, Mohammad Imran, Rana Imran Sikander, Aftab Imtiaz, Hugo Inácio, Carmen Infante Dominguez, Yun Sii Ing, Elias Iosifidis, Mariachiara Ippolito, Sarah Isgett, Tiago Isidoro, Nadiah Ismail, Margaux Isnard, Mette Stausland Istre, Junji Itai, Asami Ito, Daniel Ivulich, Danielle Jaafar, Salma Jaafoura, Julien Jabot, Clare Jackson, Nina Jamieson, Pierre Jaquet, Waasila Jassat, Coline Jaud-Fischer, Stéphane Jaureguiberry, Jeffrey Javidfar, Denise Jaworsky, Florence Jego, Anilawati Mat Jelani, Synne Jenum, Ruth Jimbo-Sotomayor, Ong Yiaw Joe, Ruth N Jorge García, Silje Bakken Jørgensen, Cédric Joseph, Mark Joseph, Swosti Joshi, Mercé Jourdain, Philippe Jouvet, Jennifer June, Anna Jung, Hanna Jung, Dafsah Juzar, Ouifiya Kafif, Florentia Kaguelidou, Neerusha Kaisbain, Thavamany Kaleesvran, Sabina Kali, Alina Kalicinska, Karl Trygve Kalleberg, Smaragdi Kalomoiri, Muhammad Aisar Ayadi Kamaluddin, Zul Amali Che Kamaruddin, Nadiah Kamarudin, Kavita Kamineni, Darshana Hewa Kandamby, Chris Kandel, Kong Yeow Kang, Darakhshan Kanwal, Dyah Kanyawati, Pratap Karpayah, Todd Karsies, Christiana Kartsonaki, Daisuke Kasugai, Anant Kataria, Kevin Katz, Aasmine Kaur, Tatsuya Kawasaki, Christy Kay, Hannah Keane, Seán Keating, Pulak Kedia, Andrea Kelly, Aoife Kelly, Claire Kelly, Niamh Kelly, Sadie Kelly, Yvelynne Kelly, Maeve Kelsey, Ryan Kennedy, Kalynn Kennon, Sommay Keomany, Maeve Kernan, Younes Kerroumi, Sharma Keshav, Evelyne Kestelyn, Imrana Khalid, Osama Khalid, Antoine Khalil, Coralie Khan, Irfan Khan, Quratul Ain Khan, Sushil Khanal, Abid Khatak, Amin Khawaja, Krish Kherajani, Michelle E Kho, Denisa Khoo, Ryan Khoo, Saye Khoo, Nasir Khoso, Khor How Kiat, Yuri Kida, Harrison Kihuga, Peter Kiiza, Beathe Kiland Granerud, Anders Benjamin Kildal, Jae Burm Kim, Antoine Kimmoun, Detlef Kindgen-Milles, Alexander King, Nobuya Kitamura, Eyrun Floerecke Kjetland Kjetland, Paul Klenerman, Rob Klont, Gry Kloumann Bekken, Stephen R Knight, Robin Kobbe, Chamira Kodippily, Malte Kohns Vasconcelos, Sabin Koirala, Mamoru Komatsu, Volkan Korten, Caroline Kosgei, Arsène Kpangon, Karolina Krawczyk, Sudhir Krishnan, Vinothini Krishnan, Oksana Kruglova, Deepali Kumar, Ganesh Kumar, Mukesh Kumar, Pavan Kumar Vecham, Dinesh Kuriakose, Ethan Kurtzman, Neurinda Permata Kusumastuti, Demetrios Kutsogiannis, Galyna Kutsyna, Konstantinos Kyriakoulis, Erwan L'Her, Marie Lachatre, Marie Lacoste, John G Laffey, Marie Lagrange, Fabrice Laine, Olivier Lairez, Sanjay Lakhey, Antonio Lalueza, Marc Lambert, François Lamontagne, Marie Langelot-Richard, Vincent Langlois, Eka Yudha Lantang, Marina Lanza, Cédric Laouénan, Samira Laribi, Delphine Lariviere, Stéphane Lasry, Sakshi Lath, Naveed Latif, Odile Launay, Didier Laureillard, Yoan Lavie-Badie, Andrew Law, Andy Law, Cassie Lawrence, Teresa Lawrence, Minh Le, Clément Le Bihan, Cyril Le Bris, Georges Le Falher, Lucie Le Fevre, Quentin Le Hingrat, Marion Le Maréchal, Soizic Le Mestre, Gwenaël Le Moal, Vincent Le Moing, Hervé Le Nagard, Paul Le Turnier, Ema Leal, Marta Leal Santos, Biing Horng Lee, Heng Gee Lee, James Lee, Su Hwan Lee, Todd C Lee, Yi Lin Lee, Gary Leeming, Bénédicte Lefebvre, Laurent Lefebvre, Benjamin Lefevre, Sylvie LeGac, Jean-Daniel Lelievre, François Lellouche, Adrien Lemaignen, Véronique Lemee, Anthony Lemeur, Gretchen Lemmink, Ha Sha Lene, Jenny Lennon, Rafael León, Marc Leone, Michela Leone, Quentin Lepiller, François-Xavier Lescure, Olivier Lesens, Mathieu Lesouhaitier, Amy Lester-Grant, Andrew Letizia, Bruno Levy, Yves Levy, Claire Levy-Marchal, Katarzyna Lewandowska, Gianluigi Li Bassi, Janet Liang, Ali Liaquat, Geoffrey Liegeon, Kah Chuan Lim, Wei Shen Lim, Chantre Lima, Bruno Lina, Lim Lina, Andreas Lind, Maja Katherine Lingad, Guillaume Lingas, Sylvie Lion-Daolio, Samantha Lissauer, Keibun Liu, Marine Livrozet, Patricia Lizotte, Antonio Loforte, Navy Lolong, Leong Chee Loon, Diogo Lopes, Dalia Lopez-Colon, Anthony L Loschner, Paul Loubet, Bouchra Loufti, Guillame Louis, Silvia Lourenco, Lara Lovelace-Macon, Lee Lee Low, Marije Lowik, Jia Shyi Loy, Jean Christophe Lucet, Carlos Lumbreras Bermejo, Carlos M Luna, Olguta Lungu, Liem Luong, Nestor Luque, Dominique Luton, Nilar Lwin, Ruth Lyons, Olavi Maasikas, Oryane Mabiala, Sarah MacDonald, Moïse Machado, Gabriel Macheda, Juan Macias Sanchez, Jai Madhok, Hashmi Madiha, Guillermo Maestro de la Calle, Jacob Magara, Giuseppe Maglietta, Rafael Mahieu, Sophie Mahy, Ana Raquel Maia, Lars S Maier, Mylène Maillet, Thomas Maitre, Maria Majori, Maximilian Malfertheiner, Nadia Malik, Paddy Mallon, Fernando Maltez, Denis Malvy, Patrizia Mammi, Victoria Manda, Jose M Mandei, Laurent Mandelbrot, Frank Manetta, Julie Mankikian, Edmund Manning, Aldric Manuel, Ceila Maria Sant'Ana Malaque, Daniel Marino, Flávio Marino, Samuel Markowicz, Charbel Maroun Eid, Ana Marques, Catherine Marquis, Brian Marsh, Laura Marsh, Megan Marshal, John Marshall, Celina Turchi Martelli, Dori-Ann Martin, Emily Martin, Guillaume Martin-Blondel, Ignacio Martin-Loeches, Alejandro Martin-Quiros, Alessandra Martinelli, Martin Martinot, Ana Martins, João Martins, Nuno Martins, Caroline Martins Rego, Gennaro Martucci, Olga Martynenko, Eva 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Metwally, Agnès Meybeck, Dan Meyer, Alison M Meynert, Vanina Meysonnier, Amina Meziane, Mehdi Mezidi, Giuliano Michelagnoli, Céline Michelanglei, Isabelle Michelet, Efstathia Mihelis, Vladislav Mihnovit, Hugo Miranda-Maldonado, Nor Arisah Misnan, Nik Nur Eliza Mohamed, Tahira Jamal Mohamed, Asma Moin, David Molina, Elena Molinos, Brenda Molloy, Mary Mone, Agostinho Monteiro, Claudia Montes, Giorgia Montrucchio, Sarah Moore, Shona C Moore, Lina Morales Cely, Lucia Moro, Diego Rolando Morocho Tutillo, Ben Morton, Catherine Motherway, Ana Motos, Hugo Mouquet, Clara Mouton Perrot, Julien Moyet, Caroline Mudara, Aisha Kalsoom Mufti, Ng Yong Muh, Dzawani Muhamad, Jimmy Mullaert, Fredrik Müller, Karl Erik Müller, Daniel Munblit, Syed Muneeb, Nadeem Munir, Laveena Munshi, Aisling Murphy, Lorna Murphy, Marlène Murris, Srinivas Murthy, Himed Musaab, Carlotta Mutti, Himasha Muvindi, Gugapriyaa Muyandy, Dimitra Melia Myrodia, Farah Nadia Mohd-Hanafiah, Dave Nagpal, Mangala Narasimhan, Nageswaran Narayanan, Rashid Nasim Khan, Alasdair Nazerali-Maitland, Nadège Neant, Holger Neb, Coca Necsoi, Nikita A Nekliudov, Erni Nelwan, Raul Neto, Emily Neumann, Bernardo Neves, Pauline Yeung Ng, Wing Yiu Ng, Anthony Nghi, Jane Ngure, Duc Nguyen, Orna Ni Choileain, Niamh Ni Leathlobhair, Alistair Nichol, Prompak Nitayavardhana, Stephanie Nonas, Nurul Amani Mohd Noordin, Marion Noret, Nurul Faten Izzati Norharizam, Lisa Norman, Alessandra Notari, Mahdad Noursadeghi, Karolina Nowicka, Adam Nowinski, Saad Nseir, Jose I Nunez, Nurnaningsih Nurnaningsih, Dwi Utomo Nusantara, Elsa Nyamankolly, Anders Benteson Nygaard, Fionnuala O Brien, Annmarie O Callaghan, Annmarie O'Callaghan, Max O'Donnell, Sophie O'Halloran, Katie O'Hearn, Conar O'Neil, Linda O'Shea, Miriam O'Sullivan, Giovanna Occhipinti, Derbrenn OConnor, Tawnya Ogston, Takayuki Ogura, Tak-Hyuk Oh, Shinichiro Ohshimo, Agnieszka Oldakowska, João Oliveira, Larissa Oliveira, Piero L Olliaro, David S Y Ong, Jee Yan Ong, Wilna Oosthuyzen, Anne Opavsky, Peter Openshaw, Saijad Orakzai, Claudia Milena Orozco-Chamorro, Andrés Orquera, Jamel Ortoleva, Javier Osatnik, Siti Zubaidah Othman, Paul Otiku, Nadia Ouamara, Rachida Ouissa, Clark Owyang, Eric Oziol, Maïder Pagadoy, Justine Pages, Amanda Palacios, Mario Palacios, Massimo Palmarini, Giovanna Panarello, Prasan Kumar Panda, Hem Paneru, Lai Hui Pang, Mauro Panigada, Nathalie Pansu, Aurélie Papadopoulos, Paolo Parducci, Edwin Fernando Paredes Oña, Rachael Parke, Melissa Parker, Briseida Parra, Vieri Parrini, Taha Pasha, Jérémie Pasquier, Bruno Pastene, Fabian Patauner, Drashti Patel, Mohan Dass Pathmanathan, Luís Patrão, Patricia Patricio, Juliette Patrier, Laura Patrizi, Lisa Patterson, Rajyabardhan Pattnaik, Christelle Paul, Mical Paul, Jorge Paulos, William A Paxton, Jean-François Payen, Kalaiarasu Peariasamy, Miguel Pedrera Jiménez, Giles J Peek, Florent Peelman, Nathan Peiffer-Smadja, Vincent Peigne, Mare Pejkovska, Paolo Pelosi, Ithan D Peltan, Rui Pereira, Daniel Perez, Luis Periel, Thomas Perpoint, Antonio Pesenti, Vincent Pestre, Lenka Petrou, Ventzislava Petrov-Sanchez, Michele Petrovic, Frank Olav Pettersen, Gilles Peytavin, Scott Pharand, Ooyanong Phonemixay, Michael Piagnerelli, Walter Picard, Olivier Picone, Maria de Piero, Carola Pierobon, Djura Piersma, Carlos Pimentel, Raquel Pinto, Catarina Pires, Isabelle Pironneau, Lionel Piroth, Roberta Pisi, Ayodhia Pitaloka, Riinu Pius, Simone Piva, Laurent Plantier, Hon Shen Png, Julien Poissy, Ryadh Pokeerbux, Maria Pokorska-Spiewak, Sergio Poli, Georgios Pollakis, Diane Ponscarme, Jolanta Popielska, Diego Bastos Porto, Andra-Maris Post, Douwe F Postma, Pedro Povoa, Diana Póvoas, Jeff Powis, Sofia Prapa, Viladeth Praphasiri, Sébastien Preau, Christian Prebensen, Jean-Charles Preiser, Anton Prinssen, Mark G Pritchard, Gamage Dona Dilanthi Priyadarshani, Lucia Proença, Sravya Pudota, Oriane Puéchal, Bambang Pujo Semedi, Mathew Pulicken, Matteo Puntoni, Gregory Purcell, Luisa Quesada, Vilmaris Quinones-Cardona, Víctor Quirós González, Else Quist-Paulsen, Mohammed Quraishi, Maia Rabaa, Christian Rabaud, Ebenezer Rabindrarajan, Aldo Rafael, Marie Rafiq, Gabrielle Ragazzo, Mutia Rahardjani, Ahmad Kashfi Haji Ab Rahman, Rozanah Abd Rahman, Arsalan Rahutullah, Fernando Rainieri, Giri Shan Rajahram, Pratheema Ramachandran, Nagarajan Ramakrishnan, Kollengode Ramanathan, Ahmad Afiq Ramli, Blandine Rammaert, Grazielle Viana Ramos, Anais Rampello, Asim Rana, Rajavardhan Rangappa, Ritika Ranjan, Elena Ranza, Christophe Rapp, Aasiyah Rashan, Thalha Rashan, Ghulam Rasheed, Menaldi Rasmin, Indrek Rätsep, Cornelius Rau, Francesco Rausa, Tharmini Ravi, Ali Raza, Andre Real, Stanislas Rebaudet, Sarah Redl, Brenda Reeve, Attaur Rehman, Liadain Reid, Dag Henrik Reikvam, Renato Reis, Jordi Rello, Jonathan Remppis, Martine Remy, Hongru Ren, Hanna Renk, Anne-Sophie Resseguier, Matthieu Revest, Oleksa Rewa, Luis Felipe Reyes, Tiago Reyes, Maria Ines Ribeiro, Antonia Ricchiuto, David Richardson, Denise Richardson, Laurent Richier, Siti Nurul Atikah Ahmad Ridzuan, Jordi Riera, Ana L Rios, Asgar Rishu, Patrick Rispal, Karine Risso, Maria Angelica Rivera Nuñez, Nicholas Rizer, Chiara Robba, André Roberto, Stephanie Roberts, David L Robertson, Olivier Robineau, Ferran Roche-Campo, Paola Rodari, Simão Rodeia, Julia Rodriguez Abreu, Bernhard Roessler, Claire Roger, Pierre-Marie Roger, Emmanuel Roilides, Amanda Rojek, Juliette Romaru, Roberto Roncon-Albuquerque Jr, Mélanie Roriz, Manuel Rosa-Calatrava, Michael Rose, Dorothea Rosenberger, Nurul Hidayah Mohammad Roslan, Andrea Rossanese, Matteo Rossetti, Sandra Rossi, Bénédicte Rossignol, Patrick Rossignol, Stella Rousset, Carine Roy, Benoît Roze, Desy Rusmawatiningtyas, Clark D Russell, Maeve Ryan, Maria Ryan, Mazankowski Heart Institute Ryckaert, Steffi Ryckaert, Aleksander Rygh Holten, Isabela Saba, Luca Sacchelli, Sairah Sadaf, Musharaf Sadat, Valla Sahraei, Nadia Saidani, Maximilien Saint-Gilles, Pranya Sakiyalak, Nawal Salahuddin, Leonardo Salazar, Jodat Saleem, Nazal Saleh, Gabriele Sales, Stéphane Sallaberry, Charlotte Salmon Gandonniere, Hélène Salvator, Olivier Sanchez, Xavier Sánchez Choez, Kizy Sanchez de Oliveira, Angel Sanchez-Miralles, Vanessa Sancho-Shimizu, Gyan Sandhu, Zulfiqar Sandhu, Pierre-François Sandrine, Oana Sandulescu, Marlene Santos, Shirley Sarfo-Mensah, Bruno Sarmento Banheiro, Iam Claire E Sarmiento, Benjamine Sarton, Ankana Satya, Sree Satyapriya, Rumaisah Satyawati, Egle Saviciute, Parthena Savvidou, Yen Tsen Saw, Justin Schaffer, Tjard Schermer, Arnaud Scherpereel, Marion Schneider, Stephan Schroll, Michael Schwameis, Gary Schwartz, Janet T Scott, James Scott-Brown, Nicholas Sedillot, Tamara Seitz, Jaganathan Selvanayagam, Mageswari Selvarajoo, Caroline Semaille, Malcolm G Semple, Rasidah Bt Senian, Eric Senneville, Claudia Sepulveda, Filipa Sequeira, Tânia Sequeira, Ary Serpa Neto, Pablo Serrano Balazote, Ellen Shadowitz, Syamin Asyraf Shahidan, Mohammad Shamsah, Anuraj Shankar, Shaikh Sharjeel, Pratima Sharma, Catherine A Shaw, Victoria Shaw, Ashraf Sheharyar, Dr Rajesh Mohan Shetty, Rohan Shetty, Haixia Shi, Nisreen Shiban, Mohiuddin Shiekh, Takuya Shiga, Nobuaki Shime, Hiroaki Shimizu, Keiki Shimizu, Naoki Shimizu, Sally Shrapnel, Pramesh Sundar Shrestha, Shubha Kalyan Shrestha, Hoi Ping Shum, Nassima Si Mohammed, Ng Yong Siang, Jeanne Sibiude, Bountoy Sibounheuang, Atif Siddiqui, Louise Sigfrid, Piret Sillaots, Catarina Silva, Maria Joao Silva, Rogério Silva, Benedict Sim Lim Heng, Wai Ching Sin, Dario Sinatti, Budha Charan Singh, Punam Singh, Pompini Agustina Sitompul, Karisha Sivam, Vegard Skogen, Sue Smith, Benjamin Smood, Coilin Smyth, Michelle Smyth, Morgane Snacken, Dominic So, Tze Vee Soh, Lene Bergendal Solberg, Joshua Solomon, Tom Solomon, Emily Somers, Agnès Sommet, Myung Jin Song, Rima Song, Tae Song, Jack Song Chia, Michael Sonntagbauer, Azlan Mat Soom, Arne Søraas, Camilla Lund Søraas, Alberto Sotto, Edouard Soum, Ana Chora Sousa, Marta Sousa, Maria Sousa Uva, Vicente Souza-Dantas, Alexandra Sperry, Elisabetta Spinuzza, B P Sanka Ruwan Sri Darshana, Shiranee Sriskandan, Sarah Stabler, Thomas Staudinger, Stephanie-Susanne Stecher, Trude Steinsvik, Ymkje Stienstra, Birgitte Stiksrud, Eva Stolz, Amy Stone, Adrian Streinu-Cercel, Anca Streinu-Cercel, Samantha Strudwick, Ami Stuart, David Stuart, Decy Subekti, Gabriel Suen, Jacky Y Suen, Asfia Sultana, Charlotte Summers, Dubravka Supic, Deepashankari Suppiah, Magdalena Surovcová, Suwarti Suwarti, Andrey A Svistunov, Sarah Syahrin, Konstantinos Syrigos, Jaques Sztajnbok, Konstanty Szuldrzynski, Shirin Tabrizi, Fabio S Taccone, Lysa Tagherset, Shahdattul Mawarni Taib, Ewa Talarek, Sara Taleb, Jelmer Talsma, Renaud Tamisier, Maria Lawrensia Tampubolon, Kim Keat Tan, Le Van Tan, Yan Chyi Tan, Clarice Tanaka, Hiroyuki Tanaka, Taku Tanaka, Hayato Taniguchi, Huda Taqdees, Arshad Taqi, Coralie Tardivon, Pierre Tattevin, M Azhari Taufik, Hassan Tawfik, Richard S Tedder, Tze Yuan Tee, João Teixeira, Sofia Tejada, Marie-Capucine Tellier, Sze Kye Teoh, Vanessa Teotonio, François Téoulé, Pleun Terpstra, Olivier Terrier, Nicolas Terzi, Hubert Tessier-Grenier, Adrian Tey, Alif Adlan Mohd Thabit, Anand Thakur, Zhang Duan Tham, Suvintheran Thangavelu, Vincent Thibault, Simon-Djamel Thiberville, Benoît Thill, Jananee Thirumanickam, Shaun Thompson, David Thomson, Emma C Thomson, Surain Raaj Thanga Thurai, Duong Bich Thuy, Ryan S Thwaites, Andrea Ticinesi, Paul Tierney, Vadim Tieroshyn, Peter S Timashev, Jean-François Timsit, Bharath Kumar Tirupakuzhi Vijayaraghavan, Noémie Tissot, Jordan Zhien Yang Toh, Maria Toki, Kristian Tonby, Sia Loong Tonnii, Antoni Torres, Margarida Torres, Rosario Maria Torres Santos-Olmo, Hernando Torres-Zevallos, Michael Towers, Tony Trapani, Théo Treoux, Huynh Trung Trieu, Cécile Tromeur, Ioannis Trontzas, Tiffany Trouillon, Jeanne Truong, Christelle Tual, Sarah Tubiana, Helen Tuite, Jean-Marie Turmel, Lance C W Turtle, Anders Tveita, Pawel Twardowski, Makoto Uchiyama, P G Ishara Udayanga, Andrew Udy, Roman Ullrich, Alberto Uribe, Asad Usman, Timothy M Uyeki, Cristinava Vajdovics, Luís Val-Flores, Piero Valentini, Ana Luiza Valle, Amélie Valran, Ilaria Valzano, Stijn Van de Velde, Marcel van den Berge, Machteld Van der Feltz, Job van der Palen, Paul van der Valk, Nicky Van Der Vekens, Peter Van der Voort, Sylvie Van Der Werf, Marlice van Dyk, Laura van Gulik, Jarne Van Hattem, Carolien van Netten, Gitte Van Twillert, Ilonka van Veen, Noémie Vanel, Henk Vanoverschelde, Pooja Varghese, Michael Varrone, Shoban Raj Vasudayan, Charline Vauchy, Shaminee Veeran, Aurélie Veislinger, Sebastian Vencken, Sara Ventura, Annelies Verbon, James Vickers, José Ernesto Vidal, César Vieira, Deepak Vijayan, Joy Ann Villanueva, Judit Villar, Pierre-Marc Villeneuve, Andrea Villoldo, Nguyen Van Vinh Chau, Gayatri Vishwanathan, Benoit Visseaux, Hannah Visser, Chiara Vitiello, Manivanh Vongsouvath, Harald Vonkeman, Fanny Vuotto, Noor Hidayu Wahab, Suhaila Abdul Wahab, Nadirah Abdul Wahid, Marina Wainstein, Wan Fadzlina Wan Muhd Shukeri, Chih-Hsien Wang, Steve Webb, Jia Wei, Katharina Weil, Tan Pei Wen, Sanne Wesselius, T Eoin West, Murray Wham, Bryan Whelan, Nicole White, Paul Henri Wicky, Aurélie Wiedemann, Surya Otto Wijaya, Keith Wille, Suzette Willems, Virginie Williams, Evert-Jan Wils, Calvin Wong, Teck Fung Wong, Xin Ci Wong, Yew Sing Wong, Natalie Wright, Gan Ee Xian, Lim Saio Xian, Kuan Pei Xuan, Ioannis Xynogalas, Sophie Yacoub, Siti Rohani Binti Mohd Yakop, Masaki Yamazaki, Yazdan Yazdanpanah, Nicholas Yee Liang Hing, Cécile Yelnik, Chian Hui Yeoh, Stephanie Yerkovich, Touxiong Yiaye, Toshiki Yokoyama, Hodane Yonis, Obada Yousif, Saptadi Yuliarto, Akram Zaaqoq, Marion Zabbe, Kai Zacharowski, Masliza Zahid, Maram Zahran, Nor Zaila Binti Zaidan, Maria Zambon, Miguel Zambrano, Alberto Zanella, Konrad Zawadka, Nurul Zaynah, Hiba Zayyad, Alexander Zoufaly, David Zucman, Durante-Mangoni, Emanuele, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Microbes in Health and Disease (MHD), Garcia-Gallo E., Merson L., Kennon K., Kelly S., Citarella B. W. , Fryer D. V. , Shrapnel S., Lee J., Duque S., Fuentes Y. V. , et al., and Medical Microbiology & Infectious Diseases

Subjects
Eğitim, Social Sciences and Humanities, Information Security and Reliability, Social Sciences (SOC), Sosyal Bilimler ve Beşeri Bilimler, Epidemiology, EDUCATION & EDUCATIONAL RESEARCH, Temel Bilimler (SCI), BİLGİSAYAR BİLİMİ, BİLGİ SİSTEMLERİ, MATHEMATICS, Sociology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Prospective Studies, COMPUTER SCIENCE, INFORMATION SYSTEMS, STATISTICS & PROBABILITY, Matematik, Bilgisayar Bilimi Uygulamaları, Computer Sciences, Bilgi Güvenliği ve Güvenilirliği, EĞİTİM VE EĞİTİM ARAŞTIRMASI, BİLGİ BİLİMİ VE KÜTÜPHANE BİLİMİ, Bilgi sistemi, Computer Science Applications, Kütüphane ve Bilgi Bilimleri, Hospitalization, Natural Sciences (SCI), Physical Sciences, Engineering and Technology, Sosyal Bilimler (SOC), Bilgisayar Bilimi, Statistics, Probability and Uncertainty, Information Systems, Human, Statistics and Probability, Humans, Pandemics, SARS-CoV-2, COVID-19, SOCIAL SCIENCES, GENERAL, Library and Information Sciences, Education, SDG 3 - Good Health and Well-being, Library Sciences, INFORMATION SCIENCE & LIBRARY SCIENCE, İstatistik ve Olasılık, Sosyal ve Beşeri Bilimler, Bilgisayar Bilimleri, Social Sciences & Humanities, Engineering, Computing & Technology (ENG), Sosyoloji, Pandemic, İSTATİSTİK & OLASILIK, Mühendislik, Bilişim ve Teknoloji (ENG), İstatistik, Olasılık ve Belirsizlik, Sosyal Bilimler Genel, COMPUTER SCIENCE, Prospective Studie, Fizik Bilimleri, Viral infection, Mühendislik ve Teknoloji, Kütüphanecilik
Abstract

The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use., This work is part of the Grand Challenges ICODA pilot initiative, delivered by Health Data Research UK and funded by the Bill & Melinda Gates Foundation and the Minderoo Foundation. The philanthropic support of the donors to the University of Oxford’s COVID-19 Research Response Fund; UK Foreign, Commonwealth and Development Office and Wellcome [215091/Z/18/Z and 220757/Z/20/Z]; the Bill & Melinda Gates Foundation [OPP1209135]; the National Institute for Health Research (NIHR; award CO-CIN-01); the Medical Research Council (MRC; grant MC_PC_19059); the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with Public Health England (PHE)(award 200907); NIHR HPRU in Respiratory Infections at Imperial College London with PHE (award 200927); Liverpool Experimental Cancer Medicine Centre (grant C18616/A25153); NIHR Biomedical Research Centre at Imperial College London (award IS-BRC-1215-20013); NIHR Clinical Research Network (infrastructure support); CIHR Coronavirus Rapid Research Funding Opportunity OV2170359 and was coordinated out of Sunnybrook Research Institute; the endorsement of the Irish Critical Care- Clinical Trials Group, co-ordinated in Ireland by the Irish Critical Care- Clinical Trials Network at University College Dublin and funded by the Health Research Board of Ireland [CTN-2014-12]; Rapid European COVID-19 Emergency Response research (RECOVER) [H2020 project 101003589]; European Clinical Research Alliance on Infectious Diseases (ECRAID) [965313]; COVID clinical management team, AIIMS, Rishikesh, India; Cambridge NIHR Biomedical Research Centre; the dedication and hard work of the Groote Schuur Hospital Covid ICU Team; the Groote Schuur nursing and University of Cape Town registrar bodies coordinated by the Division of Critical Care at the University of Cape Town; Wellcome Trust fellowship [205228/Z/16/Z]; the Liverpool School of Tropical Medicine; the University of Oxford; the dedication and hard work of the Norwegian SARS-CoV-2 study team; the Research Council of Norway grant no 312780; a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner; Innovative Medicines Initiative Joint Undertaking under Grant Agreement No. 115523 COMBACTE, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007–2013) and EFPIA companies, in-kind contribution; preparedness work conducted by the Short Period Incidence Study of Severe Acute Respiratory Infection; Stiftungsfonds zur Förderung der Bekämpfung der Tuberkulose und anderer Lungenkrankheiten of the City of Vienna, Project Number: APCOV22BGM; Italian Ministry of Health “Fondi Ricerca corrente–L1P6” to IRCCS Ospedale Sacro Cuore–Don Calabria; Australian Department of Health grant (3273191); Gender Equity Strategic Fund at University of Queensland; Artificial Intelligence for Pandemics (A14PAN) at University of Queensland; the Australian Research Council Centre of Excellence for Engineered Quantum Systems (EQUS, CE170100009); the Prince Charles Hospital Foundation, Australia; UK Medical Research Council Clinical Research Training Fellowship MR/V001671/1; Instituto de Salud Carlos III, Ministerio de Ciencia, Spain; Brazil, National Council for Scientific and Technological Development Scholarship number 303953/2018-7; Firland Foundation, Shoreline, Washington, USA; the French COVID cohort (NCT04262921) is sponsored by INSERM and is funding by the REACTing (REsearch & ACtion emergING infectious diseases) consortium and by a grant of the French Ministry of Health (PHRC n°20-0424).

Published
2022
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