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A study is done where a principal spectral component estimator called the Matrix Pencil is presented which is designed to work with each slow-time ensemble individually. A theoretical description of the matrix pencil estimation framework is given and how parametric spectral estimators can be applied to color flow signal processing is discussed.

A study is done where the Hankel-SVD filter, a new eigen-based filter, is applied to synthetic slow-time data simulated from two different sets of flow parameters that model arterial imaging and deep vessel imaging to assess its efficacy. The resulting power images showed that the Hankel-SVD filter can better distinguish blood and moving tissue regions that clutter-downmixing filter and a fixed-rank multi-ensemble-based eigen-filter.

An effective way to generate localized narrow-band low-frequency shear waves within tissue noninvasively, is by the modulated radiation force, resulting from the interference of two confocal quasi-CW ultrasound beams of slightly different frequencies. By using approximate viscoelastic Green's functions, investigations of the properties of the propagated shear-field component at the fundamental modulation frequency were previously reported by our group. However, high-amplitude source excitations may be needed to increase the signal-to-noise-ratio for shear-wave detection in tissue. This paper reports a study of the generation and propagation of dynamic radiation force components at harmonics of the modulation frequency for conditions that generally correspond to diagnostic safety standards. We describe the propagation characteristics of the resulting harmonic shear waves and discuss how they depend on the parameters of nonlinearity, focusing gain, and absorption. For conditions of high viscosity (believed to be characteristic of soft tissue) and higher modulation frequencies, the approximate shear wave Green's function is inappropriate. A more exact viscoelastic Green's function is derived in k-space, and using this, it is shown that the lowpass and dispersive effects, associated with a Voigt model of tissue, are more accurately represented. Finally, it is shown how the viscoelastic properties of the propagating medium can be estimated, based on several spectral components of the shearwave spectrum. [ABSTRACT FROM AUTHOR]

Many forms of spinal fusion involve the placement of long screws through the pedicles into the vertebral body. During the procedure, there is substantial risk of damage to vital neural and vascular structures due to the limited visibility of anatomic landmarks and high anatomic variability. As an alternative to current guidance systems, we have investigated the feasibility of performing ultrasound imaging through cancellous bone for the purpose of pedicle screw guidance. Quantitative ultrasonic characterization and A-mode imaging of seven defatted vertebral cancellous bone specimens was performed along the craniocaudal axis in water with unfocused, 1-MHz and 3.5-MHz broadband transducers. The center frequency attenuation increased considerably from 10.5 ± 4.6 dB/cm at 1 MHz to 24.1 ± 7.2 dB/cm at 3.5 MHz, while the speed of sound exhibited moderate positive dispersion, increasing from 1489 ± 4.7 m/s at 1 MHz to 1494 ± 4.2 m/s at 3.5 MHz. Despite the high attenuation and large specimen thickness (1.0-1.9 cm), A-mode imaging through cancellous bone to detect an aluminum reflector was possible in 83.2% and 70.1% of the cases at 1 MHz and 3.5 MHz, respectively. Specimen boundaries were identifiable with clinically sufficient average accuracy of 1.1 mm and 0.9 mm in the 1 MHz and 3.5 MHz A-mode images, respectively. [ABSTRACT FROM AUTHOR]

A highly localized source of low-frequency shear waves can be created by the modulated radiation force resulting from two intersecting quasi-continuous-wave ultrasound beams of slightly different frequencies. In contrast to most other radiation force-based methods, these shear waves can be narrowband. Consequently, different frequency-dependent effects will not significantly affect their spectrum as they propagate within a viscoelastic medium, thereby enabling the viscoelastic shear properties of the medium to be determined at any given modulation frequency. This can be achieved by tracking the shear wave phase delay and change in amplitude over a specific distance. In this paper we explore the properties of short duration (dynamic) low-frequency shear wave propagation and study how the shear displacement field depends on the excitation conditions. Our investigations make use of the approximate Green's functions for viscoelastic media, and the evolution of such waves is studied in the spatiotemporal domain from a theoretical perspective. Although nonlinearities are included in our confocal source model, just the properties of the fundamental shear component are examined in this paper. We examine how the shear wave propagation is affected by the shear viscosity, the coupling wave, the spatial distribution of the force, the shear speed, and the duration of the modulated wave. A method is proposed for estimating the shear viscosity of a viscoelastic medium. In addition, it is shown how the Voigt model paremeters can be extracted from the frequency-dependent speed and attenuation. [ABSTRACT FROM AUTHOR]

In Doppler ultrasound, transit-time broadening arises from the finite scatterer transit time through the sample volume. As a unifying description of this broadening mechanism, a generalized amplitude modulation signal model was developed to collectively account for the transit-time effects of the ultrasound beam geometry and the range gate characteristics. Simulations based on a pulsed linear-array system also were performed to study the broadening extent for different scatterer flow lines. With our signal model and simulation results, some generalized insights were obtained on the characteristics of transit-time broadening. First, as consistent with previous findings, we found that, for scatterers passing though the center of the sample volume, the broadening extent mainly depends on beam-forming characteristics at higher beam-flow angles, but it is more dependent on range gate parameters at smaller angles. Second, for the central flow lines a transition angle exists in which a significant change occurs in the governing parameters of transit-time broadening. Third, for the general case in which scatterers undertake an off-central path through the sample volume, the broadening extent depends on both the beam geometry and the range gate. Bandwidth skewing and further spectral broadening also can be seen for these off-central flow lines. [ABSTRACT FROM AUTHOR]

Minimally invasive recanalization of obstructed ventricular catheters is a new treatment modality currently under investigation. It has been shown that blocked ventricular catheters can be at least partly reopened with ultrasonic cavitation, fiberoptic delivery of laser energy and electrocautery. It is not known, however, how many of the holes must be reopened in order to establish acceptable pressure-flow characteristics. In this study, the pressure-flow relationship of partially obstructed ventricular catheters was determined using experimental and electrical circuit/computer models. It has been demonstrated in all cases that an additional pressure of no more than 0.5 cm of water is generated when only a single 500-μm-diameter hole in the ventricular catheter permits flow. Partial recanalization of a ventricular catheter provides acceptable CSF hydrodynamics.Copyright © 2000 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Background Context: In spinal fusion surgery, the accuracy with which screws are inserted in the pedicle has a direct effect on the surgical outcome. Accurate placement generally involves considerable judgmental skills that have been developed through a lengthy training process. Because the impact of misaligning one or more pedicle screws can directly affect patient safety, a number of navigational and trajectory verification approaches have been described and evaluated in the literature to provide some degree of guidance to the surgeon., Purpose: To provide a concise review to justify the need and explore the current state of developing navigational or trajectory verification techniques for ensuring proper pedicle screw insertion along with simulation methods for better educating the surgical trainees., Study Design: Recent literature review., Methods: To justify the need to develop new methods for optimizing pedicle screw paths, we first reviewed some of the recent publications relating to the statistical outcomes for different types of navigation along with the conventional freehand (unassisted) screw insertion. Second, because of the importance of providing improved training in the skill of accurate screw insertion, the training aspects of relevant techniques are considered. The third part is devoted to the description of specific navigational assist methods or trajectory verification techniques and these include computer-assisted navigation, three-dimensional simulations, and also electric impedance and optical and ultrasonic image-guided methods., Conclusions: This article presents an overview of the need and the current status of the guidance methods available for improving the surgical outcomes in spinal fusion procedures. It also describes educational aids that have the potential for reducing the training process., (Copyright © 2014 Elsevier Inc. All rights reserved.)

Radiation dose of X-ray Computed Tomography (CT) imaging has raised a worldwide health concern. Therefore, low-dose CT imaging has been of a huge interest in the last decade. However, lowering the radiation dose degrades the image quality by increasing the noise level, which may reduce the diagnostic performance of the images. As a result, image denoising is one of the fundamental tasks in low-dose CT imaging. One of the state of art denoising methods, which has been successfully used in this area, is Total Variation (TV) denoising. Nevertheless, if the parameters of the TV denoising are not optimally adjusted or the algorithm is not stopped in an appropriate point, some of the small structures will be removed by this method. Here, we provide a solution to this problem by proposing a modified nonlocal TV method, called probabilistic NLTV (PNLTV). Denoising performance of PNLTV is improved by using better weights and an appropriate stopping criterion based on statistics of image wavelet coefficients. Non-locality allows the algorithm to preserve the image texture, which combined with the proposed stopping criterion enables PNLTV to keep fine details unchanged.

Ultrasound simulators relying on impulse response methods are faithful to the mechanisms of image formation from the underlying radio-frequency signals, but as a result tend to be relatively slow. At the other extreme are fast techniques, often motivated by the development of teaching and training simulators, which approximate the image formation processes rather than rigorously modeling the underlying physics. Previously, we have shown that transmit field distributions from linear phased-array transducers can be modeled accurately and efficiently using arrays of point sources. This approach is now extended to point sources/receivers, which allows for simulation of the transmit/receive fields, and thus the physical processes underlying ultrasound image formation. Field distributions and fast-time signals are shown to compare favorably to those obtained using the impulse response method. Doppler spectrogram and B-mode images derived from these signals also show excellent agreement with the results obtained using the impulse response method, but with a computational savings of nearly two orders of magnitude. Because of the inherent simplicity of our Fast and Mechanistic Ultrasound Simulation (FAMUS) approach, CPU parallelization was readily achieved, and further orders of magnitude speed improvements, and thus real-time performance, can be anticipated via extension to modern graphics processing units.

A plane piston transducer can be focused by a continuous variation of the excitation signal phase (or time delay) over the transducer surface. Prior analyses of this scheme used the Fresnel approximation, thereby limiting the validity. Using the angular spectrum method, an accurate radiation model of such a transducer has been developed that includes amplitude and phase apodization. The derivation includes the effects of diffraction and evanescent waves without using the Fresnel approximation. Moreover, this model develops insights into radiated field characteristics, including: (a) the spatial frequency bandwidth is constant over axial depth, suggesting that spatial resolution can be improved away from the focus; (b) the phase of the angular spectrum determines the spatial resolution for a given transducer configuration-a constant phase is optimal on any observation plane; (c) focusing can significantly increase the spatial frequency bandwidth; (d) the velocity potential on a plane parallel to the transducer is the Hankel convolution of the transducer surface velocity with the Green's function; and (e) evanescent waves decay both with increasing spatial frequency and axial depth. The analytical model and associated insights enhance understanding of the radiated field characteristics, which can be of value in the development of signal processing techniques for image enhancement., (Copyright © 2012 Elsevier B.V. All rights reserved.)