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In order to ensure indoor air quality safety, locating the airborne contaminant sources accurately and quickly is extremely important so that timely measures can be taken to undermine the spread of pollutant and even eliminate the negative effects. Previous studies have shown that the multi-zone model can greatly reduce the inverse calculation time. However, the multi-zone model cannot describe the details of the indoor velocity field, which limits its application in complex multi-zone or large space buildings. On the premise of the accuracy and computational speed, based on the joint probability method, this study adopted the coarse-grid CFD method to speed up the process of acquiring the indoor airflow field, together with the multi-zone model method, to perform the inverse calculation of indoor airborne contaminant source location. In the backward calculation process, we conducted the 'transpose' of the velocity field to obtain adjoint matrix, instead of computing 'negative' of the velocity vector to save the calculation time. A two-dimensional ventilation model was utilized to validate the method, which proved the accuracy and time-saving potential of it. This study provides theoretical and practical prospect for the real-time inverse calculation of locating the indoor airborne contaminant sources. [ABSTRACT FROM AUTHOR]