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3 results on '"CoMSAS"'

1. A novel safety assessment strategy for non-intentionally added substances (NIAS) in carton food contact materials.

Author

Koster, Sander, Rennen, Monique, Leeman, Winfried, Houben, Geert, Muilwijk, Bas, van Acker, Frederique, and Krul, Lisette

Subjects
*FOOD packaging, *PACKAGING materials, *FOOD safety, *FOOD additives, *PAPER containers, *HEALTH risk assessment
Abstract

One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess their health risk upon exposure, whereas the health relevance at low exposure levels might not even be an issue. This paper describes a scientifically based, but pragmatic safety assessment approach for unknown substances present at low exposure levels in food contact matrices. This complex mixture safety assessment strategy (CoMSAS) enables one to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure, and allows one to focus on the substances of potential health concern. In particular, substances for which exposure will be below certain thresholds may be considered not of health relevance in case specific classes of substances are excluded. This can reduce the amount of work needed for identification, characterisation and evaluation of unknown substances at low concentration. The CoMSAS approach is presented in this paper using a safety assessment of unknown NIAS that may migrate from three carton samples. [ABSTRACT FROM PUBLISHER]

Published
2014
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2. A novel safety assessment strategy for non-intentionally added substances (NIAS) in carton food contact materials

Subjects
NIAS, Safety engineering, CoMSAS, Aflatoxin B1, Aflatoxin B2, Alkene, Limit of detection, Alkane, RAPID - Risk Assessment Products in Development, Carboxylic acid, Life, Fast food, Ergocristine, Aflatoxin, Complex mixture safety assessment strategy, Evaluation, Risk assessment, T 2 toxin, Electric contacts, Nivalenol, Food contact materials, Health, Threshold of toxicological concern, Food matrix, Aflatoxin M1, Zearalenone, Safety, Healthy Living, TTC, Ergometrine, Accident prevention, Liquid chromatography, Mass fragmentography, Ergocryptine, Assessment, Ether, Organophosphate pesticide, Article, Fumonisin B1, Food safety, Health hazard, Food packaging, Biphenyl derivative, Ergotamine, Food and Nutrition, Vomitoxin, Life and Social Sciences, Carbamate pesticide, Ergocornine, Nutrition, Food additive, Food analysis, Volatile agent, Non-intentionally added substances, ELSS - Earth, Dibenzodioxin derivative, HT 2 toxin, Ochratoxin, Mixtures, Concentration (parameters), Dibenzofuran derivative, Aflatoxin G1, Alcohol derivative, Genotoxicity, Controlled study, Aflatoxin G2
Abstract

One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess their health risk upon exposure, whereas the health relevance at low exposure levels might not even be an issue. This paper describes a scientifically based, but pragmatic safety assessment approach for unknown substances present at low exposure levels in food contact matrices. This complex mixture safety assessment strategy (CoMSAS) enables one to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure, and allows one to focus on the substances of potential health concern. In particular, substances for which exposure will be below certain thresholds may be considered not of health relevance in case specific classes of substances are excluded. This can reduce the amount of work needed for identification, characterisation and evaluation of unknown substances at low concentration. The CoMSAS approach is presented in this paper using a safety assessment of unknown NIAS that may migrate from three carton samples. © 2014 Taylor & Francis. Chemicals/CAS: aflatoxin, 1402-68-2; aflatoxin B1, 1162-65-8; aflatoxin B2, 7220-81-7; aflatoxin G1, 1165-39-5; aflatoxin G2, 7241-98-7; aflatoxin M1, 6795-23-9; ergocornine, 564-36-3; ergocristine, 511-08-0; ergocryptine, 511-09-1; ergometrine, 60-79-7; ergotamine, 113-15-5, 52949-35-6; ether, 60-29-7; fumonisin B1, 116355-83-0; HT 2 toxin, 26934-87-2; nivalenol, 23282-20-4; ochratoxin, 303-47-9, 37203-43-3; T 2 toxin, 21259-20-1; vomitoxin, 51481-10-8; zearalenone, 17924-92-4

Published
2014

3. A novel safety assessment strategy for non-intentionally added substances (NIAS) in carton food contact materials

Author

W.R. Leeman, Bas Muilwijk, Sander Koster, Frederique van Acker, Monique Rennen, Lisette Krul, and Geert F. Houben

Subjects
NIAS, Safety engineering, Aflatoxin, CoMSAS, Food contact materials, business.product_category, Aflatoxin B1, Aflatoxin B2, Alkene, Health, Toxicology and Mutagenesis, Limit of detection, Ergocristine, Alkane, RAPID - Risk Assessment Products in Development, Toxicology, Carboxylic acid, chemistry.chemical_compound, Vomitoxin, Life, Fast food, Complex mixture safety assessment strategy, Evaluation, Zearalenone, Risk assessment, T 2 toxin, General Medicine, Electric contacts, Nivalenol, Health, Threshold of toxicological concern, Food matrix, Aflatoxin M1, Safety, Hazard Analysis and Critical Control Points, Plastics, Healthy Living, TTC, Ergometrine, Paper, Accident prevention, Liquid chromatography, Mass fragmentography, Food Contamination, Ergocryptine, Complex Mixtures, Assessment, Ether, Gas Chromatography-Mass Spectrometry, Organophosphate pesticide, Article, Fumonisin B1, Food safety, Health hazard, Food packaging, Biphenyl derivative, Ergotamine, Humans, Food and Nutrition, Carbamate pesticide, Ergocornine, Ochratoxin, Nutrition, No-Observed-Adverse-Effect Level, Food additive, Food analysis, Volatile agent, Public Health, Environmental and Occupational Health, General Chemistry, Allergens, Non-intentionally added substances, Dibenzodioxin derivative, Carton, HT 2 toxin, chemistry, Mixtures, Concentration (parameters), Dibenzofuran derivative, Aflatoxin G1, ELSS - Earth, Life and Social Sciences, Alcohol derivative, Genotoxicity, business, Controlled study, Aflatoxin G2, Mutagens, Food Science
Abstract

One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess their health risk upon exposure, whereas the health relevance at low exposure levels might not even be an issue. This paper describes a scientifically based, but pragmatic safety assessment approach for unknown substances present at low exposure levels in food contact matrices. This complex mixture safety assessment strategy (CoMSAS) enables one to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure, and allows one to focus on the substances of potential health concern. In particular, substances for which exposure will be below certain thresholds may be considered not of health relevance in case specific classes of substances are excluded. This can reduce the amount of work needed for identification, characterisation and evaluation of unknown substances at low concentration. The CoMSAS approach is presented in this paper using a safety assessment of unknown NIAS that may migrate from three carton samples. © 2014 Taylor & Francis. Chemicals/CAS: aflatoxin, 1402-68-2; aflatoxin B1, 1162-65-8; aflatoxin B2, 7220-81-7; aflatoxin G1, 1165-39-5; aflatoxin G2, 7241-98-7; aflatoxin M1, 6795-23-9; ergocornine, 564-36-3; ergocristine, 511-08-0; ergocryptine, 511-09-1; ergometrine, 60-79-7; ergotamine, 113-15-5, 52949-35-6; ether, 60-29-7; fumonisin B1, 116355-83-0; HT 2 toxin, 26934-87-2; nivalenol, 23282-20-4; ochratoxin, 303-47-9, 37203-43-3; T 2 toxin, 21259-20-1; vomitoxin, 51481-10-8; zearalenone, 17924-92-4

Published
2014

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