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7. The neurophysiological brain-fingerprint of Parkinson’s disease

Author

Breitner, John, Poirier, Judes, Baillet, Sylvain, Bellec, Pierre, Bohbot, Véronique, Chakravarty, Mallar, Collins, Louis, Etienne, Pierre, Evans, Alan, Gauthier, Serge, Hoge, Rick, Ituria-Medina, Yasser, Multhaup, Gerhard, Münter, Lisa-Marie, Rajah, Natasha, Rosa-Neto, Pedro, Soucy, Jean-Paul, Vachon-Presseau, Etienne, Villeneuve, Sylvia, Amouyel, Philippe, Appleby, Melissa, Ashton, Nicholas, Auld, Daniel, Ayranci, Gülebru, Bedetti, Christophe, Beland, Marie-Lise, Blennow, Kaj, Westman, Ann Brinkmalm, Cuello, Claudio, Dadar, Mahsa, Daoust, Leslie-Ann, Das, Samir, Dauar-Tedeschi, Marina, De Beaumont, Louis, Dea, Doris, Descoteaux, Maxime, Dufour, Marianne, Farzin, Sarah, Ferdinand, Fabiola, Fonov, Vladimir, Gonneaud, Julie, Kat, Justin, Kazazian, Christina, Labonté, Anne, Lafaille-Magnan, Marie-Elyse, Lalancette, Marc, Lambert, Jean-Charles, Leoutsakos, Jeannie-Marie, Mahar, Laura, Mathieu, Axel, McSweeney, Melissa, Meyer, Pierre-François, Miron, Justin, Near, Jamie, NewboldFox, Holly, Nilsson, Nathalie, Orban, Pierre, Picard, Cynthia, Binette, Alexa Pichet, Poline, Jean-Baptiste, Rabipour, Sheida, Salaciak, Alyssa, Settimi, Matthew, Subramaniapillai, Sivaniya, Tam, Angela, Tardif, Christine, Théroux, Louise, Tremblay-Mercier, Jennifer, Tullo, Stephanie, Ulku, Irem, Vallée, Isabelle, Zetterberg, Henrik, Nair, Vasavan, Pruessner, Jens, Aisen, Paul, Anthal, Elena, Barkun, Alan, Beaudry, Thomas, Benbouhoud, Fatiha, Brandt, Jason, Carmo, Leopoldina, Carrier, Charles Edouard, Cheewakriengkrai, Laksanun, Courcot, Blandine, Couture, Doris, Craft, Suzanne, Dansereau, Christian, Debacker, Clément, Desautels, René, Dubuc, Sylvie, Duclair, Guerda, Eisenberg, Mark, El-Khoury, Rana, Faubert, Anne-Marie, Fontaine, David, Frappier, Josée, Frenette, Joanne, Gagné, Guylaine, Gervais, Valérie, Giles, Renuka, Gordon, Renee, Jack, Clifford, Jutras, Benoit, Khachaturian, Zaven, Knopman, David, Kostopoulos, Penelope, Lapalme, Félix, Lee, Tanya, Lepage, Claude, Leppert, Illana, Madjar, Cécile, Maillet, David, Maltais, Jean-Robert, Mathotaarachchi, Sulantha, Mayrand, Ginette, Michaud, Diane, Montine, Thomas, Morris, John, Pagé, Véronique, Pascoal, Tharick, Peillieux, Sandra, Petkova, Mirela, Pogossova, Galina, Rioux, Pierre, Sager, Mark, Saint-Fort, Eunice Farah, Savard, Mélissa, Sperling, Reisa, Tabrizi, Shirin, Tariot, Pierre, Teigner, Eduard, Thomas, Ronald, Toussaint, Paule-Joanne, Tuwaig, Miranda, Venugopalan, Vinod, Verfaillie, Sander, Vogel, Jacob, Wan, Karen, Wang, Seqian, Yu, Elsa, Beaulieu-Boire, Isabelle, Blanchet, Pierre, Bogard, Sarah, Bouchard, Manon, Chouinard, Sylvain, Cicchetti, Francesca, Cloutier, Martin, Dagher, Alain, Degroot, Clotilde, Desautels, Alex, Dion, Marie Hélène, Drouin-Ouellet, Janelle, Dufresne, Anne-Marie, Dupré, Nicolas, Duquette, Antoine, Durcan, Thomas, Fellows, Lesley K., Fon, Edward, Gagnon, Jean-François, Gan-Or, Ziv, Genge, Angela, Jodoin, Nicolas, Karamchandani, Jason, Lafontaine, Anne-Louise, Langlois, Mélanie, Leveille, Etienne, Lévesque, Martin, Melmed, Calvin, Monchi, Oury, Montplaisir, Jacques, Panisset, Michel, Parent, Martin, Pham-An, Minh-Thy, Postuma, Ronald, Pourcher, Emmanuelle, Rao, Trisha, Rivest, Jean, Rouleau, Guy, Sharp, Madeleine, Soland, Valérie, Sidel, Michael, Wing Sun, Sonia Lai, Thiel, Alexander, Vitali, Paolo, da Silva Castanheira, Jason, Wiesman, Alex I., Hansen, Justine Y., and Misic, Bratislav

Published
2024
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18. A Real-world Assessment of Healthcare Resource Utilization and Costs among Patients with Agitation Related to Alzheimer's Dementia Living in Private Homes and Residential Facilities

Author

Grossberg, George T, primary, Talon, Brian, additional, Schein, Jeff, additional, Bungay, Rebecca, additional, Cloutier, Martin, additional, Gauthier-Loiselle, Marjolaine, additional, Chan, Deborah, additional, Guerin, Annie, additional, and Aggarwal, Jyoti, additional

Published
2024
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21. Illustrating 'What is a sound strategy system?'

Author

Hadaya, Pierre, Cloutier, Martin, Hadaya, Pierre, and Cloutier, Martin

Abstract

A sound strategy system (often called strategy management system) is essential to the long-term success of any organization. It is the comprehensive and integrated set of continuously executed strategy-related activities that permits an organization to be effective, agile, and efficient in today’s increasingly competitive, global and technology-driven market. Yet, despite its importance and all that has been learned since the launch of the business strategy revolution in the 1960s, most organizations are still having great difficulties devising and implementing such a complex system. The absence of a sound management system, in turn, is probably the key factor explaining why 50% to 90% of strategic initiatives fail and why the life expectancy of organizations is in a serious decline. To begin addressing this important gap, the objective of this article is to make an initial attempt to illustrate the key components of a strategy system and how they are related to one another. To do so, we rely on a modeling technique from systems thinking. In addition to identifying the key components of such a system, this technique enables us to capture the feedback loops amongst these key components that strategists and executives must understand and put in place for their organization to be effective, agile, and efficient to succeed in the long-term.

Published
2024

22. Treatment Preferences of Adult Patients with Attention-Deficit/Hyperactivity Disorder – A Discrete Choice Experiment

Author

Schein,Jeff, Cloutier,Martin, Gauthier-Loiselle,Marjolaine, Catillon,Maryaline, Meng,Yan, Libchaber,Beatrice, Jiang,Fanny, Childress,Ann, Schein,Jeff, Cloutier,Martin, Gauthier-Loiselle,Marjolaine, Catillon,Maryaline, Meng,Yan, Libchaber,Beatrice, Jiang,Fanny, and Childress,Ann

Abstract

Jeff Schein,1 Martin Cloutier,2 Marjolaine Gauthier-Loiselle,2 Maryaline Catillon,3 Yan Meng,4 Beatrice Libchaber,2 Fanny Jiang,2 Ann Childress5 1Otsuka Pharmaceutical Development & Commercialization, Inc, Princeton, NJ, USA; 2Analysis Group, Inc, Montréal, QC, Canada; 3Analysis Group, Inc, New York, NY, USA; 4Analysis Group, Inc, London, UK; 5Center for Psychiatry and Behavioral Medicine, Las Vegas, NV, USACorrespondence: Maryaline Catillon, Analysis Group, Inc, 151 West 42nd Street, 23rd Floor, New York, NY, 10036, USA, Tel +1 857 222 6863, Email maryaline.catillon@analysisgroup.comBackground: Understanding patient preferences for treatments may facilitate shared decision-making. This study assessed adult patient preferences for attention-deficit/hyperactivity disorder (ADHD) treatments in a sample of 600 patients in the United States (US).Methods: A web-based discrete choice experiment (DCE) survey was conducted among treated adults with ADHD. Participants were recruited from Dynata’s US panel (06/22/2023-07/06/2023). Attributes and levels, identified based on clinical inputs and published data, included efficacy and safety. Participants’ preferences were estimated using conditional logistic regression. Willingness to trade-off and attributes’ relative importance were calculated. Overall preferences for treatment profiles approximating centanafadine, lisdexamfetamine, atomoxetine, and viloxazine were estimated using adjusted total utilities. Results were stratified by current treatment status. Sensitivity analyses including participants who passed validity tests were conducted.Results: Among the 600 participants (mean age 37.9 years; 66.2% female; 50.8% treated), all attributes had a statistically significant impact on preferences for ADHD treatments (p < 0.001); the most important attribute was improvement in ADHD symptoms (36%), followed by risks of nausea (25%), insomnia (20%), anxiety (8%), dry mouth (6%), and feeling jittery (5%). Together, saf

Published
2024

23. Scanning tunneling spectroscopy reveals a silicon dangling bond charge state transition

Author

Labidi, Hatem, Taucer, Marco, Rashidi, Mohammad, Koleini, Mohammad, Livadaru, Lucian, Pitters, Jason, Cloutier, Martin, Salomons, Mark, and Wolkow, Robert A.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

We report the study of single dangling bonds (DB) on the hydrogen terminated silicon (100) surface using a low temperature scanning tunneling microscope (LT-STM). By investigating samples prepared with different annealing temperatures, we establish the critical role of subsurface arsenic dopants on the DB electronic properties. We show that when the near surface concentration of dopants is depleted as a result of $1250{\deg}C$ flash anneals, a single DB exhibits a sharp conduction step in its I(V) spectroscopy that is not due to a density of states effect but rather corresponds to a DB charge state transition. The voltage position of this transition is perfectly correlated with bias dependent changes in STM images of the DB at different charge states. Density functional theory (DFT) calculations further highlight the role of subsurface dopants on DB properties by showing the influence of the DB-dopant distance on the DB state. We discuss possible theoretical models of electronic transport through the DB that could account for our experimental observations., Comment: 21 pages, 6 figures

Published
2015
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24. Treatment Preferences of Adult Patients with Attention-Deficit/Hyperactivity Disorder – A Discrete Choice Experiment.

Author

Schein, Jeff, Cloutier, Martin, Gauthier-Loiselle, Marjolaine, Catillon, Maryaline, Meng, Yan, Libchaber, Beatrice, Jiang, Fanny, and Childress, Ann

Subjects
*PATIENT preferences, *PATIENT satisfaction, *ATTENTION-deficit hyperactivity disorder, *XEROSTOMIA, *PATIENT-centered care
Abstract

Background: Understanding patient preferences for treatments may facilitate shared decision-making. This study assessed adult patient preferences for attention-deficit/hyperactivity disorder (ADHD) treatments in a sample of 600 patients in the United States (US). Methods: A web-based discrete choice experiment (DCE) survey was conducted among treated adults with ADHD. Participants were recruited from Dynata's US panel (06/22/2023-07/06/2023). Attributes and levels, identified based on clinical inputs and published data, included efficacy and safety. Participants' preferences were estimated using conditional logistic regression. Willingness to trade-off and attributes' relative importance were calculated. Overall preferences for treatment profiles approximating centanafadine, lisdexamfetamine, atomoxetine, and viloxazine were estimated using adjusted total utilities. Results were stratified by current treatment status. Sensitivity analyses including participants who passed validity tests were conducted. Results: Among the 600 participants (mean age 37.9 years; 66.2% female; 50.8% treated), all attributes had a statistically significant impact on preferences for ADHD treatments (p < 0.001); the most important attribute was improvement in ADHD symptoms (36%), followed by risks of nausea (25%), insomnia (20%), anxiety (8%), dry mouth (6%), and feeling jittery (5%). Together, safety attributes accounted for > 60% of relative importance in decision-making. Participants were willing to forgo 0.59, 0.57, 0.49, 0.32, and 0.17 percentage points of symptom improvement to achieve one-percentage-point reduced risk of insomnia, nausea, anxiety, feeling jittery, and dry mouth, respectively. Centanafadine profile had consistently higher adjusted total utilities than its comparators. Similar results were obtained in the subgroup and sensitivity analyses. Conclusion: Efficacy was the most important attribute for patients when making treatment decision, but taken together, AEs had greater relative importance than efficacy alone. Accordingly, a profile resembling that of centanafadine would be preferred by an average patient compared to key competitors due to its favorable safety profile. These findings may help improve treatment decision-making, enhance treatment satisfaction, and foster adherence. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Assessment of centanafadine in adults with ADHD: a matching adjusted indirect comparison versus methylphenidate hydrochloride extended release (Concerta).

Author

Schein, Jeff, Cloutier, Martin, Gauthier-Loiselle, Marjolaine, Catillon, Maryaline, Xu, Chunyi, Qu, Alice, and Childress, Ann

Subjects
*ATTENTION-deficit hyperactivity disorder, *METHYLPHENIDATE, *DRUG side effects, *ADVERSE health care events, *XEROSTOMIA
Abstract

To compare safety and efficacy of centanafadine versus methylphenidate hydrochloride extended release (ER; Concerta) in adults with ADHD. Without head-to-head trials, anchored matching-adjusted indirect comparisons (MAIC) of adverse event rates reported across trials and mean change from baseline in Adult ADHD Investigator Symptom Rating Scale (AISRS) score between centanafadine and methylphenidate hydrochloride ER were conducted. Pooled patient-level data from two centanafadine trials (NCT03605680/NCT03605836) and aggregate data from one published methylphenidate hydrochloride ER trial (NCT00937040) were used. Characteristics of individual patients from the centanafadine trials were matched to aggregate baseline characteristics from the methylphenidate hydrochloride ER trial using propensity score weighting. A sensitivity analysis assessed the robustness of the results to the capping of extreme weights (i.e. >99th percentile). Compared with methylphenidate hydrochloride ER, centanafadine was associated with significantly lower risk of dry mouth (risk difference [RD] in percentage points: −11.95), initial insomnia (−11.10), decreased appetite (−8.05), anxiety (−5.39), palpitations (−5.25), and feeling jittery (−4.73) though a significantly smaller reduction in AISRS score (4.16-point). In the sensitivity analysis, the safety results were consistent with the primary analysis but there was no significant difference in efficacy between centanafadine and methylphenidate hydrochloride ER. In this MAIC, centanafadine had better safety and possibly lower efficacy than methylphenidate hydrochloride ER. While safety results were robust across analyses, there was no efficacy difference between centanafadine and methylphenidate hydrochloride ER in the sensitivity analysis. Considering its favorable safety profile, centanafadine may be preferred among patients for whom treatment-related adverse events are a concern. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Mental Health and Health-Related Quality of Life Among Nephrology Nurses: A Survey-Based Cross-Sectional Study

Author

Montoya, Vicki, Donnini, Katie, Gauthier-Loiselle, Marjolaine, Sanon, Myrlene, Cloutier, Martin, Maitland, Jessica, Guerin, Annie, Dutka, Paula, Pryor, Lillian, Thomas-Hawkins, Charlotte, Voegel, Arthur, Hoffmann, Mark, Savin, Samuel, Kurzman, Alissa, and Kear, Tamara

Subjects
Job stress -- Causes of -- Risk factors, Work environment -- Psychological aspects -- Health aspects, Burn out (Psychology) -- Causes of -- Risk factors, Nurses -- Social aspects -- Health aspects -- Psychological aspects, Quality of life -- Health aspects, Health
Abstract

Nephrology nurses face health and wellness challenges due to significant work-related stressors. This survey, conducted online between July 24 and August 17, 2020, assessed the psychological well-being of nephrology nurses in the United States during the COVID-19 pandemic (n = 393). Respondents reported feeling burned out from work (62%), symptoms of anxiety (47% with Generalized Anxiety Disorder-7 [GAD-7] scores [greater than or equal to] 5), and major depressive episodes (16% with Patient Health Questionnaire-2 [PHQ2] scores [greater than or equal to] 3). Fifty-six percent (56%) of survey respondents reported caring for COVID-19 patients, and 62% were somewhat or very worried about COVID-19. Factors, including high workload, age, race, and the COVID-19 pandemic, may partially explain the high proportion of nephrology nurses who reported symptoms of burnout, anxiety, and depression. Key Words: Nephrology nurses, mental health outcomes, health-related quality of life, mental health survey., Nephrology nurses provide complex technological care to large numbers of patients who have a substantial clinical burden (Li et al., 2018). This care can also involve providing long-term support to [...]

Published
2021

28. Silicon Atomic Quantum Dots Enable Beyond-CMOS Electronics

Author

Wolkow, Robert A., Livadaru, Lucian, Pitters, Jason, Taucer, Marco, Piva, Paul, Salomons, Mark, Cloutier, Martin, and Martins, Bruno V. C.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We review our recent efforts in building atom-scale quantum-dot cellular automata circuits on a silicon surface. Our building block consists of silicon dangling bond on a H-Si(001) surface, which has been shown to act as a quantum dot. First the fabrication, experimental imaging, and charging character of the dangling bond are discussed. We then show how precise assemblies of such dots can be created to form artificial molecules. Such complex structures can be used as systems with custom optical properties, circuit elements for quantum-dot cellular automata, and quantum computing. Considerations on macro-to-atom connections are discussed., Comment: 28 pages, 19 figures

Published
2013

35. Response to: Alfred Sandrock, Wildon Farwell. Letter to the Editor, Comparisons Between Separately Conducted Clinical Trials: Letter to the Editor Regarding Dabbous O, Maru B, Jansen JP, Lorenzi M, Cloutier M, Guérin A, et al. Adv Ther (2019) 36(5):1164-76. doi:10.1007/s12325-019-00923-8

Author

Dabbous, Omar, Maru, Benit, Jansen, Jeroen P., Lorenzi, Maria, Cloutier, Martin, Guérin, Annie, Pivneva, Irina, Wu, Eric Q., Arjunji, Ramesh, Feltner, Douglas, and Sproule, Douglas M.

Published
2019
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39. NanoMi: Progress on an Open-source Electron Microscope

Author

Schreiber, Makoto, primary, Malac, Marek, additional, Salomons, Mark, additional, Homeniuk, Darren, additional, Ruttiman, Sam, additional, Wang, Xuanhao, additional, Adkin-Kaya, Olivier, additional, Kamal, Mohammad, additional, Calzada, Jesus Alejandro Marin, additional, Price, Patrick, additional, Cloutier, Martin, additional, Hayashida, Misa, additional, Egerton, Ray, additional, Harada, Ken, additional, Takahashi, Yoshio, additional, and Müller, Heiko, additional

Published
2023
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42. Silicon Atomic Quantum Dots Enable Beyond-CMOS Electronics

Author

Wolkow, Robert A., Livadaru, Lucian, Pitters, Jason, Taucer, Marco, Piva, Paul, Salomons, Mark, Cloutier, Martin, Martins, Bruno V. C., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Anderson, Neal G., editor, and Bhanja, Sanjukta, editor

Published
2014
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43. Impact of Invasive Escherichia ColiDisease on Clinical Outcomes and Medical Resource Utilization Among Asian Patients in the United States

Author

Zhuo, Chao, Zheng, Bo, Wattanakamolkul, Kittima, Nakayama, Yoshikazu, Cloutier, Martin, Gauthier-Loiselle, Marjolaine, Feng, Jun, Wu, David, Neary, Maureen P., Geurtsen, Jeroen, El Khoury, Antoine C., and Gu, Yoshiaki

Abstract

Introduction: Invasive Escherichia colidisease (IED) can lead to sepsis and death and is associated with a substantial burden. Yet, there is scarce information on the burden of IED in Asian patients. Methods: This retrospective study used US hospital data from the PINC AI™ Healthcare database (October 2015–March 2020) to identify IED cases among patients aged ≥ 60 years. IED was defined as a positive E. coliculture in blood or other normally sterile body site (group 1 IED) or positive culture of E. coliin urine with signs of sepsis (group 2 IED). Eligible patients with IED were classified into Asian and non-Asian cohorts based on their reported race. Entropy balancing was used to create cohorts with similar characteristics. Outcomes following IED were descriptively reported in the balanced cohorts. Results: A total of 646 Asian and 19,127 non-Asian patients with IED were included (median age 79 years; 68% female after balancing). For both cohorts, most IED encounters had community-onset (> 95%) and required hospitalization (Asian 96%, mean duration 6.9 days; non-Asian 95%, mean duration 6.8 days), with frequent admission to intensive care (Asian 35%, mean duration 3.3 days; non-Asian 34%, mean duration 3.5 days), all standardized differences [SD] &lt; 0.20. Compared to non-Asian patients, Asian patients were more likely to be discharged home (54% vs. 43%; SD = 0.22), and less likely to be discharged to a skilled nursing facility (24% vs. 31%; SD = 0.16). In-hospital fatality rates during the IED encounter were similar across cohorts (Asian 9%, non-Asian 10%; SD = 0.01). Most E. coliisolates showed resistance to ≥ 1 antibiotic (Asian 61%; non-Asian 64%) and 36% to ≥ 3 antibiotic classes (all SD &lt; 0.20). Conclusion: IED is associated with a substantial burden, including need for intensive care and considerable mortality, in Asian patients in the USA that is consistent with that observed for non-Asian patients.

Published
2024
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44. Association between agitated behaviors and hospitalizations in community-dwelling individuals with Alzheimer's dementia: An assessment based on the Cohen-Mansfield Agitation Inventory

Author

Grossberg, George, primary, Willey, Cynthia, additional, Houle, Christy, additional, Schein, Jeff, additional, Bungay, Rebecca, additional, Cloutier, Martin, additional, Gauthier-Loiselle, Marjolaine, additional, Chan, Deborah, additional, Guerin, Annie, additional, and Aggarwal, Jyoti, additional

Published
2023
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46. NanoMi - An Open Source Transmission Electron Microscope

Author

Malac, Marek, Wen, Zhengxu (Darren), Kumar, Karan, Chen, Sean, Salomons, Mark, Cloutier, Martin, Homeniuk, Darren, Egerton, Ray, C, J., Price, Patrick, Hayashida, Misa, Vick, Douglas, Kamal, Mohammad, Yakubu, Suliat, Dayneko, Sergey, Au, Ricky, Martis, Joel, Feist, Armin, Czarnecki, Adam, Kim, Yohan, Akar, Orhan, Leeson, Marcus, caballero, juan, zhang, zongteng, and Wang, Xuanhao

Subjects
open source, electron microscopy, nanotechnology, engineering, microscopy, TEM, physics
Abstract

NanoMi is a project towards an open source modular electron microscope. It will allow to assemble transmission electron microscope (TEM) column, scanning TEM (STEM) column or scanning electron microscope (SEM) column. The goal of the NanoMi project is to establish framework for a community development of an electron microscope. Perhaps most important aspect is the license that covers the development: CERN Open Hardware v2, weakly reciprocal for hardware components. https://cern-ohl.web.cern.ch/ and GPL v3 for software (see below)

Published
2022
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47. NanoMi: An open source electron microscope hardware and software platform

Author

Malac, Marek, primary, Calzada, Jesus Alejandro Marin, additional, Salomons, Mark, additional, Homeniuk, Darren, additional, Price, Patrick, additional, Cloutier, Martin, additional, Hayashida, Misa, additional, Vick, Doug, additional, Chen, Sean, additional, Yakubu, Suliat, additional, Wen, Zhengxu (Darren), additional, Leeson, Marcus, additional, Kamal, Mohammad, additional, Pitters, Jason, additional, Kim, John, additional, Wang, Xuanhao, additional, Adkin-Kaya, Olivier, additional, and Egerton, Ray, additional

Published
2022
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