Travel abroad provides a challenge for even the most seasoned traveler, but the introduction of the special needs of an infant or child into the equation creates an even more complicated situation. It is an old adage that "children are not merely small adults" and no where is this more evident than in traveling to an undeveloped country where every step, every bite, and every breath could be potentially life-threatening. Adults have well-developed immune systems to protect themselves against many pathogens, but, more important, they have the life experiences and thought processes that enable them to avoid danger and when threatened to find a solution for survival. Infants and children, in addition to being particularly vulnerable because of a naive immune system and developing physiologic protective mechanisms, depend on adults to make decisions for them and anticipate possible dangers. With appropriate planning, however, travel abroad may even be safer than staying at home. 12 Preparation for travel must begin weeks before traveling by selecting a travel advisor and obtaining necessary immunizations and counseling. It continues through the process of travel with risk assessments made along the way based on a thorough understanding of the child's special needs. And it does not cease when the family arrives home, because chemoprophylaxis may need to be continued and a heightened awareness for illnesses acquired while traveling must be maintained. Parents will need to be counseled regarding choice of a travel advisor. Travelers frequently receive incorrect information, 8 which may result in preventable morbidity and mortality. Therefore, it is preferable to obtain information from a travel medicine center if one is available. An appropriate center to evaluate children for travel will be familiar with the particular needs of children traveling, provide information about risk reduction, provide prescriptions for chemoprophylaxis, have a mechanism for follow-up if necessary, and have in stock the commonly used vaccines for travel. Yellow fever vaccine requires a special license. An ideal travel medicine center counsels about not only health-related factors and disease prevention, but can provide information about obtaining resources about obtaining passports and visas, foreign health insurance, and advisories about political unrest in the country. Planning needs to begin about 6 to 8 weeks before travel. Routine immunization schedules are complicated and may need to be altered to provide the maximum immunity before traveling, for example, measles vaccine is not normally given until 12 months, but a dose may be given earlier if measles is endemic in the area of travel. After discussion, it may be necessary to postpone travel until an infant can be appropriately immunized or have the infant join the family later. For example, in an area of endemic pertussis, it would be unwise to travel with an infant younger than 6 months of age who has not received the three primary immunization series. Administration of live virus vaccines in combination with others complicates the immunization schedule even further so careful logistics are necessary to ensure that all recommended vaccines can be given before departing. Parents will need advice on a number of topics. Preparation for travel even across the state to grandmother's house can seem daunting, what with diapers, formula, toys, car seats, and other extra equipment, but this is amplified when traveling overseas. Many of these common items are not available at the corner store, so to avoid both overpacking and being caught unprepared, research should be done about what is available. The most important item to plan for is food. It is estimated that one third of travelers from industrialized countries to undeveloped countries will have travelers diarrhea. 10 Planning is especially important for infants on formula. Concentrate and powdered forms are most convenient, but a clean water supply must be available. This may require purchasing a system to purify water and knowing its limitations or learning how to make water pure yourself. Disposable diapers are not generally available in undeveloped countries and are bulky to pack, so it may be necessary to purchase cloth diapers and provide for laundering them. If possible, when reserving rental cars, vehicles with seatbelts should be requested and car seats should be brought by the family, because availability is not guaranteed. Traveling with portable cribs and high chairs is not practical in most circumstances, so imaginative solutions are needed, for example, using a drawer from a dresser as a bassinet. Assembly of a medicine kit is essential. Based on the child's age and history, most needs can be anticipated. See Table 1 for a sample kit. In addition, an adequate supply of any regular or intermittent medications should be brought. Examples of these would be medication for a seizure disorder and antibiotic prophylaxis for otitis. For diabetics, insulin and a mechanism for keeping it refrigerated must be insured, as well as an adequate supply of needles. In addition, a letter from a doctor stating that the needles are to be used by a diabetic may be required in some countries. A copy of a prescription for corrective lenses or if travel is anticipated to be lengthy, an extra pair of glasses or contact lenses should be brought. Ideally, these are carried in the carry-on luggage, which is less likely to be lost. Children with hearing aids or limb prostheses provide an added challenge, and facilities should be identified in advance to handle these needs. Traveling is stressful for children, and appropriate emotional preparation needs to be done. Even if the family is traveling for a short time, the details of tying up loose ends and packing are time consuming and often involve short tempers, such that attention to a child's normal needs gets overlooked. This is amplified with the child "acting out" and the cycle worsening. As a result, everyone boards the plane exhausted and overwrought. In situations where the family is going overseas for prolonged periods or are relocating, the stress level is even higher. Additionally, there are the issues facing any child who is moving such as fear of the unknown and grieving over the anticipated loss of friends and contact with familiar people and places. In both of these situations, attention to the child's needs will lessen the anxiety. Specifically, having the child choose a favorite toy to take along, allowing the child to ask questions, and (when age appropriate) discussing fears and anxieties are all helpful.