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1. Clioquinol, a drug for AlzheimerEs disease specifically interfering with brain metal metabolism: Structural characterization of its zinc(II) and copper(II) complexes

Author

Vaira, Massimo Di, Bazzicalupi, Carla, Orioli, Pierluigi, Messori, Luigi, Bruni, Bruno, and Zatta, Paolo

Subjects
Copper -- Chemical properties, Zinc -- Chemical properties, Alzheimer's disease -- Care and treatment, Clioquinol -- Production processes, Clioquinol -- Usage, Chemistry
Abstract

A structural characterization of the zinc(II) and copper(II) complexes of clioquinol is reported. A ligand to metal stoichiometry of 2:1 is found in both cases, though in the presence of quite different coordination polyhedra, the findings are discussed in the frame of modern approaches to AlzheimerEs disease treatment.

Published
2004

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