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1. Requirements on the gain calibration for LiteBIRD polarisation data with blind component separation

Author

Carralot, F., Carones, A., Krachmalnicoff, N., Ghigna, T., Novelli, A., Pagano, L., Piacentini, F., Baccigalupi, C., Adak, D., Anand, A., Aumont, J., Azzoni, S., Ballardini, M., Banday, A. J., Barreiro, R. B., Bartolo, N., Basak, S., Basyrov, A., Bersanelli, M., Bortolami, M., Brinckmann, T., Cacciotti, F., Campeti, P., Carinos, E., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Conenna, G., Coppi, G., Coppolecchia, A., Cuttaia, F., de Bernardis, P., De Lucia, M., Della Torre, S., Di Giorgi, E., Diego-Palazuelos, P., Essinger-Hileman, T., Ferreira, E., Finelli, F., Franceschet, C., Galloni, G., Galloway, M., Gervasi, M., Génova-Santos, R. T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., Gruppuso, A., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Hivon, E., Ishino, H., Jost, B., Kohri, K., Lamagna, L., Leloup, C., Lembo, M., Levrier, F., Lonappan, A. I., López-Caniego, M., Luzzi, G., Macias-Perez, J., Martínez-González, E., Masi, S., Matarrese, S., Matsumura, T., Micheli, S., Monelli, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Nagano, Y., Nagata, R., Namikawa, T., Natoli, P., Obata, I., Occhiuzzi, A., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Patanchon, G., Pavlidou, V., Pisano, G., Polenta, G., Porcelli, L., Puglisi, G., Raffuzzi, N., Remazeilles, M., Rubiño-Martín, J. A., Ruiz-Granda, M., Sanghavi, J., Scott, D., Shiraishi, M., Sullivan, R. M., Takase, Y., Tassis, K., Terenzi, L., Tomasi, M., Tristram, M., Vacher, L., van Tent, B., Vielva, P., Weymann-Despres, G., Wollack, E. J., Zannoni, M., and Zhou, Y.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Future cosmic microwave background (CMB) experiments are primarily targeting a detection of the primordial $B$-mode polarisation. The faintness of this signal requires exquisite control of systematic effects which may bias the measurements. In this work, we derive requirements on the relative calibration accuracy of the overall polarisation gain ($\Delta g_\nu$) for LiteBIRD experiment, through the application of the blind Needlet Internal Linear Combination (NILC) foreground-cleaning method. We find that minimum variance techniques, as NILC, are less affected by gain calibration uncertainties than a parametric approach, which requires a proper modelling of these instrumental effects. The tightest constraints are obtained for frequency channels where the CMB signal is relatively brighter (166 GHz channel, $\Delta {g}_\nu \approx 0.16 \%$), while, with a parametric approach, the strictest requirements were on foreground-dominated channels. We then propagate gain calibration uncertainties, corresponding to the derived requirements, into all frequency channels simultaneously. We find that the overall impact on the estimated $r$ is lower than the required budget for LiteBIRD by almost a factor $5$. The adopted procedure to derive requirements assumes a simple Galactic model. We therefore assess the robustness of obtained results against more realistic scenarios by injecting the gain calibration uncertainties, according to the requirements, into LiteBIRD simulated maps and assuming intermediate- and high-complexity sky models. In this case, we employ the so-called Multi-Clustering NILC (MC-NILC) foreground-cleaning pipeline and obtain that the impact of gain calibration uncertainties on $r$ is lower than the LiteBIRD gain systematics budget for the intermediate-complexity sky model. For the high-complexity case, instead, it would be necessary to tighten the requirements by a factor $1.8$., Comment: 29 pages, 11 figures

Published
2024

2. Multi-dimensional optimisation of the scanning strategy for the LiteBIRD space mission

Author

Takase, Y., Vacher, L., Ishino, H., Patanchon, G., Montier, L., Stever, S. L., Ishizaka, K., Nagano, Y., Wang, W., Aumont, J., Aizawa, K., Anand, A., Baccigalupi, C., Ballardini, M., Banday, A. J., Barreiro, R. B., Bartolo, N., Basak, S., Bersanelli, M., Bortolami, M., Brinckmann, T., Calabrese, E., Campeti, P., Carinos, E., Carones, A., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Coppolecchia, A., Cuttaia, F., de Bernardis, P., de Haan, T., de la Hoz, E., Della Torre, S., Diego-Palazuelos, P., D'Alessandro, G., Eriksen, H. K., Errard, J., Finelli, F., Fuskeland, U., Galloni, G., Galloway, M., Gervasi, M., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., González, R. González, Gruppuso, A., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Ikuma, K., Kohri, K., Lamagna, L., Lattanzi, M., Leloup, C., Lembo, M., Levrier, F., Lonappan, A. I., López-Caniego, M., Luzzi, G., Maffei, B., Martínez-González, E., Masi, S., Matarrese, S., Matsuda, F. T., Matsumura, T., Micheli, S., Migliaccio, M., Monelli, M., Morgante, G., Mot, B., Nagata, R., Namikawa, T., Novelli, A., Odagiri, K., Oguri, S., Omae, R., Pagano, L., Paoletti, D., Piacentini, F., Pinchera, M., Polenta, G., Porcelli, L., Raffuzzi, N., Remazeilles, M., Ritacco, A., Ruiz-Granda, M., Sakurai, Y., Scott, D., Sekimoto, Y., Shiraishi, M., Signorelli, G., Sullivan, R. M., Takakura, H., Terenzi, L., Tomasi, M., Tristram, M., van Tent, B., Vielva, P., Wehus, I. K., Westbrook, B., Weymann-Despres, G., Wollack, E. J., Zannoni, M., and Zhou, Y.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Large angular scale surveys in the absence of atmosphere are essential for measuring the primordial $B$-mode power spectrum of the Cosmic Microwave Background (CMB). Since this proposed measurement is about three to four orders of magnitude fainter than the temperature anisotropies of the CMB, in-flight calibration of the instruments and active suppression of systematic effects are crucial. We investigate the effect of changing the parameters of the scanning strategy on the in-flight calibration effectiveness, the suppression of the systematic effects themselves, and the ability to distinguish systematic effects by null-tests. Next-generation missions such as LiteBIRD, modulated by a Half-Wave Plate (HWP), will be able to observe polarisation using a single detector, eliminating the need to combine several detectors to measure polarisation, as done in many previous experiments and hence avoiding the consequent systematic effects. While the HWP is expected to suppress many systematic effects, some of them will remain. We use an analytical approach to comprehensively address the mitigation of these systematic effects and identify the characteristics of scanning strategies that are the most effective for implementing a variety of calibration strategies in the multi-dimensional space of common spacecraft scan parameters. We also present Falcons, a fast spacecraft scanning simulator that we developed to investigate this scanning parameter space.

Published
2024

3. French COhoRte Extra-Vascular Implantable CardiovErter DefibrillatoR (FOREVER)

Author

European Georges Pompidou Hospital, University Hospital, Grenoble, University Hospital, Clermont-Ferrand, Centre Hospitalier Universitaire de Rouen, Centre Hospitalier Universitaire de Besancon, Clinique du Millenaire, Institut Mutualiste Montsouris, Groupe Hospitalier Pitie-Salpetriere, University Hospital, Lille, University Hospital, Caen, Hospices Civils de Lyon, CHU de la Timone, Marseille, France, Centre Cardio-Thoracique de Monaco, Hospital of Lens, Institute Arnault Tzanck, France, University Hospital, Strasbourg, France, University Hospital, Limoges, University Hospital, Montpellier, Clinique Pasteur Toulouse, University Hospital, Bordeaux, University Hospital, Toulouse, Institut Jacques Cartier - Massy, Clinique Saint Augustin - Bordeaux, Rennes University Hospital, Clinique de la Sauvegarde, University Hospital of Saint-Etienne, Centre Hospitalier Universitaire, Amiens, Poitiers University Hospital, Clinique Saint-Gatien - Tours, CHU de Reims, Centre Hospitalier Universitaire Dijon, Hospital St. Joseph, Marseille, France, Centre Hospitalier Annecy Genevois, Clinique St Pierre, Perpignan, France, Bichat Hospital, Universite de La Reunion, University Hospital Center of Martinique, Henri Mondor University Hospital, University Hospital, Angers, Central Hospital, Nancy, France, Hôpital privé Clairval - Marseille, Médipôle Lyon-Villeurbanne, Hôpital Privé Les Franciscaines, Hospital Ambroise Paré Paris, Central Hospital, Metz Thionville, France, Hopital Prive Saint Martin - Bordeaux, Hôpital Privé de Parly II - Le Chesnay, and Marijon, Head of Cardiology Division

Published
2024

5. Personalized Spacing of Eculizumab Infusions Based on Therapeutic Pharmacological Monitoring (EspacECU) (EspacECU)

Author

Centre Hospitalier Universitaire, Amiens, University Hospital, Angers, Centre Hospitalier Universitaire de Besancon, University Hospital, Caen, Centre Hospitalier of Chartres, Nantes University Hospital, University of Nancy, Poitiers University Hospital, Rennes University Hospital, University Hospital, Rouen, University Hospital, Strasbourg, France, Centre Hospitalier Universitaire de Nice, Hôpital Necker-Enfants Malades, Tenon Hospital, Paris, University Hospital, Lille, Reims University Hospital, University Hospital, Clermont-Ferrand, Assistance Publique Hopitaux De Marseille, and Hospices Civils de Lyon

Published
2024

8. LiteBIRD Science Goals and Forecasts. Mapping the Hot Gas in the Universe

Author

Remazeilles, M., Douspis, M., Rubiño-Martín, J. A., Banday, A. J., Chluba, J., de Bernardis, P., De Petris, M., Hernández-Monteagudo, C., Luzzi, G., Macias-Perez, J., Masi, S., Namikawa, T., Salvati, L., Tanimura, H., Aizawa, K., Anand, A., Aumont, J., Baccigalupi, C., Ballardini, M., Barreiro, R. B., Bartolo, N., Basak, S., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Calabrese, E., Campeti, P., Carinos, E., Carones, A., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Coppolecchia, A., Cuttaia, F., de Haan, T., de la Hoz, E., Della Torre, S., Diego-Palazuelos, P., D'Alessandro, G., Eriksen, H. K., Finelli, F., Fuskeland, U., Galloni, G., Galloway, M., Gervasi, M., Génova-Santos, R. T., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., González, R. González, Gruppuso, A., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Herranz, D., Kohri, K., Komatsu, E., Lamagna, L., Lattanzi, M., Leloup, C., Levrier, F., Lonappan, A. I., López-Caniego, M., Maffei, B., Martínez-González, E., Matarrese, S., Matsumura, T., Micheli, S., Migliaccio, M., Monelli, M., Montier, L., Morgante, G., Nagano, Y., Nagata, R., Novelli, A., Omae, R., Pagano, L., Paoletti, D., Pavlidou, V., Piacentini, F., Pinchera, M., Polenta, G., Porcelli, L., Ritacco, A., Ruiz-Granda, M., Sakurai, Y., Scott, D., Shiraishi, M., Stever, S. L., Sullivan, R. M., Takase, Y., Tassis, K., Terenzi, L., Tomasi, M., Tristram, M., Vacher, L., van Tent, B., Vielva, P., Wehus, I. K., Westbrook, B., Weymann-Despres, G., Wollack, E. J., Zannoni, M., and Zhou, Y.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We assess the capabilities of the LiteBIRD mission to map the hot gas distribution in the Universe through the thermal Sunyaev-Zeldovich (SZ) effect. Our analysis relies on comprehensive simulations incorporating various sources of Galactic and extragalactic foreground emission, while accounting for specific instrumental characteristics of LiteBIRD, such as detector sensitivities, frequency-dependent beam convolution, inhomogeneous sky scanning, and $1/f$ noise. We implement a tailored component-separation pipeline to map the thermal SZ Compton $y$-parameter over 98% of the sky. Despite lower angular resolution for galaxy cluster science, LiteBIRD provides full-sky coverage and, compared to the Planck satellite, enhanced sensitivity, as well as more frequency bands to enable the construction of an all-sky $y$-map, with reduced foreground contamination at large and intermediate angular scales. By combining LiteBIRD and Planck channels in the component-separation pipeline, we obtain an optimal $y$-map that leverages the advantages of both experiments, with the higher angular resolution of the Planck channels enabling the recovery of compact clusters beyond the LiteBIRD beam limitations, and the numerous sensitive LiteBIRD channels further mitigating foregrounds. The added value of LiteBIRD is highlighted through the examination of maps, power spectra, and one-point statistics of the various sky components. After component separation, the $1/f$ noise from LiteBIRD is effectively mitigated below the thermal SZ signal at all multipoles. Cosmological constraints on $S_8=\sigma_8\left(\Omega_{\rm m}/0.3\right)^{0.5}$ obtained from the LiteBIRD-Planck combined $y$-map power spectrum exhibits a 15% reduction in uncertainty compared to constraints from Planck alone. This improvement can be attributed to the increased portion of uncontaminated sky available in the LiteBIRD-Planck combined $y$-map., Comment: 38 pages, 13 figures, abstract shortened. Updated to match version accepted by JCAP

Published
2024

9. The PLATO Mission

Author

Rauer, Heike, Aerts, Conny, Cabrera, Juan, Deleuil, Magali, Erikson, Anders, Gizon, Laurent, Goupil, Mariejo, Heras, Ana, Lorenzo-Alvarez, Jose, Marliani, Filippo, Martin-Garcia, César, Mas-Hesse, J. Miguel, O'Rourke, Laurence, Osborn, Hugh, Pagano, Isabella, Piotto, Giampaolo, Pollacco, Don, Ragazzoni, Roberto, Ramsay, Gavin, Udry, Stéphane, Appourchaux, Thierry, Benz, Willy, Brandeker, Alexis, Güdel, Manuel, Janot-Pacheco, Eduardo, Kabath, Petr, Kjeldsen, Hans, Min, Michiel, Santos, Nuno, Smith, Alan, Suarez, Juan-Carlos, Werner, Stephanie C., Aboudan, Alessio, Abreu, Manuel, a, Lorena Acu, Adams, Moritz, Adibekyan, Vardan, Affer, Laura, Agneray, François, Agnor, Craig, Børsen-Koch, Victor Aguirre, Ahmed, Saad, Aigrain, Suzanne, Al-Bahlawan, Ashraf, Gil, M de los Angeles Alcacera, Alei, Eleonora, Alencar, Silvia, Alexander, Richard, Alfonso-Garzón, Julia, Alibert, Yann, Prieto, Carlos Allende, Almeida, Leonardo, Sobrino, Roi Alonso, Altavilla, Giuseppe, Althaus, Christian, Trujillo, Luis Alonso Alvarez, Amarsi, Anish, Eiff, Matthias Ammler-von, Amôres, Eduardo, Andrade, Laerte, Antoniadis-Karnavas, Alexandros, António, Carlos, del Moral, Beatriz Aparicio, Appolloni, Matteo, Arena, Claudio, Armstrong, David, Aliaga, Jose Aroca, Asplund, Martin, Audenaert, Jeroen, Auricchio, Natalia, Avelino, Pedro, Baeke, Ann, Baillié, Kevin, Balado, Ana, Balagueró, Pau Ballber, Balestra, Andrea, Ball, Warrick, Ballans, Herve, Ballot, Jerome, Barban, Caroline, Barbary, Gaële, Barbieri, Mauro, Forteza, Sebasti Barceló, Barker, Adrian, Barklem, Paul, Barnes, Sydney, Navascues, David Barrado, Barragan, Oscar, Baruteau, Clément, Basu, Sarbani, Baudin, Frederic, Baumeister, Philipp, Bayliss, Daniel, Bazot, Michael, Beck, Paul G., Bedding, Tim, Belkacem, Kevin, Bellinger, Earl, Benatti, Serena, Benomar, Othman, Bérard, Diane, Bergemann, Maria, Bergomi, Maria, Bernardo, Pierre, Biazzo, Katia, Bignamini, Andrea, Bigot, Lionel, Billot, Nicolas, Binet, Martin, Biondi, David, Biondi, Federico, Birch, Aaron C., Bitsch, Bertram, Ceballos, Paz Victoria Bluhm, Bódi, Attila, Bognár, Zsófia, Boisse, Isabelle, Bolmont, Emeline, Bonanno, Alfio, Bonavita, Mariangela, Bonfanti, Andrea, Bonfils, Xavier, Bonito, Rosaria, Bonomo, Aldo Stefano, Börner, Anko, Saikia, Sudeshna Boro, Martín, Elisa Borreguero, Borsa, Francesco, Borsato, Luca, Bossini, Diego, Bouchy, Francois, Boué, Gwenaël, Boufleur, Rodrigo, Boumier, Patrick, Bourrier, Vincent, Bowman, Dominic M., Bozzo, Enrico, Bradley, Louisa, Bray, John, Bressan, Alessandro, Breton, Sylvain, Brienza, Daniele, Brito, Ana, Brogi, Matteo, Brown, Beverly, Brown, David J. A., Brun, Allan Sacha, Bruno, Giovanni, Bruns, Michael, Buchhave, Lars A., Bugnet, Lisa, Buldgen, Gaël, Burgess, Patrick, Busatta, Andrea, Busso, Giorgia, Buzasi, Derek, Caballero, José A., Cabral, Alexandre, Gomez, Juan-Francisco Cabrero, Calderone, Flavia, Cameron, Robert, Cameron, Andrew, Campante, Tiago, Gestal, Néstor Campos, Martins, Bruno Leonardo Canto, Cara, Christophe, Carone, Ludmila, Carrasco, Josep Manel, Casagrande, Luca, Casewell, Sarah L., Cassisi, Santi, Castellani, Marco, Castro, Matthieu, Catala, Claude, Fernández, Irene Catalán, Catelan, Márcio, Cegla, Heather, Cerruti, Chiara, Cessa, Virginie, Chadid, Merieme, Chaplin, William, Charpinet, Stephane, Chiappini, Cristina, Chiarucci, Simone, Chiavassa, Andrea, Chinellato, Simonetta, Chirulli, Giovanni, Christensen-Dalsgaard, Jørgen, Church, Ross, Claret, Antonio, Clarke, Cathie, Claudi, Riccardo, Clermont, Lionel, Coelho, Hugo, Coelho, Joao, Cogato, Fabrizio, Colomé, Josep, Condamin, Mathieu, García, Fernando Conde, Conseil, Simon, Corbard, Thierry, Correia, Alexandre C. M., Corsaro, Enrico, Cosentino, Rosario, Costes, Jean, Cottinelli, Andrea, Covone, Giovanni, Creevey, Orlagh L., Crida, Aurelien, Csizmadia, Szilard, Cunha, Margarida, Curry, Patrick, da Costa, Jefferson, da Silva, Francys, Dalal, Shweta, Damasso, Mario, Damiani, Cilia, Damiani, Francesco, Chagas, Maria Liduina das, Davies, Melvyn, Davies, Guy, Davies, Ben, Davison, Gary, de Almeida, Leandro, de Angeli, Francesca, de Barros, Susana Cristina Cabral, Leão, Izan de Castro, de Freitas, Daniel Brito, de Freitas, Marcia Cristina, De Martino, Domitilla, de Medeiros, José Renan, de Paula, Luiz Alberto, Gómez, Álvaro de Pedraza, de Plaa, Jelle, De Ridder, Joris, Deal, Morgan, Decin, Leen, Deeg, Hans, Innocenti, Scilla Degl, Deheuvels, Sebastien, del Burgo, Carlos, Del Sordo, Fabio, Delgado-Mena, Elisa, Demangeon, Olivier, Denk, Tilmann, Derekas, Aliz, Desert, Jean-Michel, Desidera, Silvano, Dexet, Marc, Di Criscienzo, Marcella, Di Giorgio, Anna Maria, Di Mauro, Maria Pia, Rial, Federico Jose Diaz, Díaz-García, José-Javier, Dima, Marco, Dinuzzi, Giacomo, Dionatos, Odysseas, Distefano, Elisa, Nascimento Jr., Jose-Dias do, Domingo, Albert, D'Orazi, Valentina, Dorn, Caroline, Doyle, Lauren, Duarte, Elena, Ducellier, Florent, Dumaye, Luc, Dumusque, Xavier, Dupret, Marc-Antoine, Eggenberger, Patrick, Ehrenreich, David, Eigmüller, Philipp, Eising, Johannes, Emilio, Marcelo, Eriksson, Kjell, Ermocida, Marco, Giribaldi, Riano Isidoro Escate, Eschen, Yoshi, ez, Lucía Espinosa Yá, Estrela, In s, Evans, Dafydd Wyn, Fabbian, Damian, Fabrizio, Michele, Faria, João Pedro, Farina, Maria, Farinato, Jacopo, Feliz, Dax, Feltzing, Sofia, Fenouillet, Thomas, Fernández, Miguel, Ferrari, Lorenza, Ferraz-Mello, Sylvio, Fialho, Fabio, Fienga, Agnes, Figueira, Pedro, Fiori, Laura, Flaccomio, Ettore, Focardi, Mauro, Foley, Steve, Fontignie, Jean, Ford, Dominic, Fornazier, Karin, Forveille, Thierry, Fossati, Luca, Franca, Rodrigo de Marca, da Silva, Lucas Franco, Frasca, Antonio, Fridlund, Malcolm, Furlan, Marco, Gabler, Sarah-Maria, Gaido, Marco, Gallagher, Andrew, Sempere, Paloma I. Gallego, Galli, Emanuele, García, Rafael A., Hernández, Antonio García, Munoz, Antonio Garcia, García-Vázquez, Hugo, Haba, Rafael Garrido, Gaulme, Patrick, Gauthier, Nicolas, Gehan, Charlotte, Gent, Matthew, Georgieva, Iskra, Ghigo, Mauro, Giana, Edoardo, Gill, Samuel, Girardi, Leo, Winter, Silvia Giuliatti, Giusi, Giovanni, da Silva, João Gomes, Zazo, Luis Jorge Gómez, Gomez-Lopez, Juan Manuel, Hernández, Jonay Isai González, Murillo, Kevin Gonzalez, Melchor, Alejandro Gonzalo, Gorius, Nicolas, Gouel, Pierre-Vincent, Goulty, Duncan, Granata, Valentina, Grenfell, John Lee, bach, Denis Grie, Grolleau, Emmanuel, Grouffal, Salomé, Grziwa, Sascha, Guarcello, Mario Giuseppe, Gueguen, Lo c, Guenther, Eike Wolf, Guilhem, Terrasa, Guillerot, Lucas, Guillot, Tristan, Guiot, Pierre, Guterman, Pascal, Gutiérrez, Antonio, Gutiérrez-Canales, Fernando, Hagelberg, Janis, Haldemann, Jonas, Hall, Cassandra, Handberg, Rasmus, Harrison, Ian, Harrison, Diana L., Hasiba, Johann, Haswell, Carole A., Hatalova, Petra, Hatzes, Artie, Haywood, Raphaelle, Hébrard, Guillaume, Heckes, Frank, Heiter, Ulrike, Hekker, Saskia, Heller, René, Helling, Christiane, Helminiak, Krzysztof, Hemsley, Simon, Heng, Kevin, Herbst, Konstantin, Hermans, Aline, Hermes, JJ, Torres, Nadia Hidalgo, Hinkel, Natalie, Hobbs, David, Hodgkin, Simon, Hofmann, Karl, Hojjatpanah, Saeed, Houdek, Günter, Huber, Daniel, Huesler, Joseph, Hui-Bon-Hoa, Alain, Huygen, Rik, Huynh, Duc-Dat, Iro, Nicolas, Irwin, Jonathan, Irwin, Mike, Izidoro, André, Jacquinod, Sophie, Jannsen, Nicholas Emborg, Janson, Markus, Jeszenszky, Harald, Jiang, Chen, Mancebo, Antonio José Jimenez, Jofre, Paula, Johansen, Anders, Johnston, Cole, Jones, Geraint, Kallinger, Thomas, Kálmán, Szilárd, Kanitz, Thomas, Karjalainen, Marie, Karjalainen, Raine, Karoff, Christoffer, Kawaler, Steven, Kawata, Daisuke, Keereman, Arnoud, Keiderling, David, Kennedy, Tom, Kenworthy, Matthew, Kerschbaum, Franz, Kidger, Mark, Kiefer, Flavien, Kintziger, Christian, Kislyakova, Kristina, Kiss, László, Klagyivik, Peter, Klahr, Hubert, Klevas, Jonas, Kochukhov, Oleg, Köhler, Ulrich, Kolb, Ulrich, Koncz, Alexander, Korth, Judith, Kostogryz, Nadiia, Kovács, Gábor, Kovács, József, Kozhura, Oleg, Krivova, Natalie, Kucinskas, Arunas, Kuhlemann, Ilyas, Kupka, Friedrich, Laauwen, Wouter, Labiano, Alvaro, Lagarde, Nadege, Laget, Philippe, Laky, Gunter, Lam, Kristine Wai Fun, Lambrechts, Michiel, Lammer, Helmut, Lanza, Antonino Francesco, Lanzafame, Alessandro, Martiz, Mariel Lares, Laskar, Jacques, Latter, Henrik, Lavanant, Tony, Lawrenson, Alastair, Lazzoni, Cecilia, Lebre, Agnes, Lebreton, Yveline, Etangs, Alain Lecavelier des, Lee, Katherine, Leinhardt, Zoe, Leleu, Adrien, Lendl, Monika, Leto, Giuseppe, Levillain, Yves, Libert, Anne-Sophie, Lichtenberg, Tim, Ligi, Roxanne, Lignieres, Francois, Lillo-Box, Jorge, Linsky, Jeffrey, Liu, John Scige, Loidolt, Dominik, Longval, Yuying, Lopes, Ilídio, Lorenzani, Andrea, Ludwig, Hans-Guenter, Lund, Mikkel, Lundkvist, Mia Sloth, Luri, Xavier, Maceroni, Carla, Madden, Sean, Madhusudhan, Nikku, Maggio, Antonio, Magliano, Christian, Magrin, Demetrio, Mahy, Laurent, Maibaum, Olaf, Malac-Allain, LeeRoy, Malapert, Jean-Christophe, Malavolta, Luca, Maldonado, Jesus, Mamonova, Elena, Manchon, Louis, Manjón, Andres, Mann, Andrew, Mantovan, Giacomo, Marafatto, Luca, Marconi, Marcella, Mardling, Rosemary, Marigo, Paola, Marinoni, Silvia, Marques, rico, Marques, Joao Pedro, Marrese, Paola Maria, Marshall, Douglas, Perales, Silvia Martínez, Mary, David, Marzari, Francesco, Masana, Eduard, Mascher, Andrina, Mathis, Stéphane, Mathur, Savita, Vodopivec, Iris Martín, Figueiredo, Ana Carolina Mattiuci, Maxted, Pierre F. L., Mazeh, Tsevi, Mazevet, Stephane, Mazzei, Francesco, McCormac, James, McMillan, Paul, Menou, Lucas, Merle, Thibault, Meru, Farzana, Mesa, Dino, Messina, Sergio, Mészáros, Szabolcs, Meunier, Nadége, Meunier, Jean-Charles, Micela, Giuseppina, Michaelis, Harald, Michel, Eric, Michielsen, Mathias, Michtchenko, Tatiana, Miglio, Andrea, Miguel, Yamila, Milligan, David, Mirouh, Giovanni, Mitchell, Morgan, Moedas, Nuno, Molendini, Francesca, Molnár, László, Mombarg, Joey, Montalban, Josefina, Montalto, Marco, Monteiro, Mário J. P. F. G., Sánchez, Francisco Montoro, Morales, Juan Carlos, Morales-Calderon, Maria, Morbidelli, Alessandro, Mordasini, Christoph, Moreau, Chrystel, Morel, Thierry, Morello, Guiseppe, Morin, Julien, Mortier, Annelies, Mosser, Beno t, Mourard, Denis, Mousis, Olivier, Moutou, Claire, Mowlavi, Nami, Moya, Andrés, Muehlmann, Prisca, Muirhead, Philip, Munari, Matteo, Musella, Ilaria, Mustill, Alexander James, Nardetto, Nicolas, Nardiello, Domenico, Narita, Norio, Nascimbeni, Valerio, Nash, Anna, Neiner, Coralie, Nelson, Richard P., Nettelmann, Nadine, Nicolini, Gianalfredo, Nielsen, Martin, Niemi, Sami-Matias, Noack, Lena, Noels-Grotsch, Arlette, Noll, Anthony, Norazman, Azib, Norton, Andrew J., Nsamba, Benard, Ofir, Aviv, Ogilvie, Gordon, Olander, Terese, Olivetto, Christian, Olofsson, Göran, Ong, Joel, Ortolani, Sergio, Oshagh, Mahmoudreza, Ottacher, Harald, Ottensamer, Roland, Ouazzani, Rhita-Maria, Paardekooper, Sijme-Jan, Pace, Emanuele, Pajas, Miriam, Palacios, Ana, Palandri, Gaelle, Palle, Enric, Paproth, Carsten, Parro, Vanderlei, Parviainen, Hannu, Granado, Javier Pascual, Passegger, Vera Maria, Pastor-Morales, Carmen, Pätzold, Martin, Pedersen, May Gade, Hidalgo, David Pena, Pepe, Francesco, Pereira, Filipe, Persson, Carina M., Pertenais, Martin, Peter, Gisbert, Petit, Antoine C., Petit, Pascal, Pezzuto, Stefania, Pichierri, Gabriele, Pietrinferni, Adriano, Pinheiro, Fernando, Pinsonneault, Marc, Plachy, Emese, Plasson, Philippe, Plez, Bertrand, Poppenhaeger, Katja, Poretti, Ennio, Portaluri, Elisa, Portell, Jordi, de Mello, Gustavo Frederico Porto, Poyatos, Julien, Pozuelos, Francisco J., Moroni, Pier Giorgio Prada, Pricopi, Dumitru, Prisinzano, Loredana, Quade, Matthias, Quirrenbach, Andreas, Reina, Julio Arturo Rabanal, Soares, Maria Cristina Rabello, Raimondo, Gabriella, Rainer, Monica, Rodón, Jose Ramón, Ramón-Ballesta, Alejandro, Zapata, Gonzalo Ramos, Rätz, Stefanie, Rauterberg, Christoph, Redman, Bob, Redmer, Ronald, Reese, Daniel, Regibo, Sara, Reiners, Ansgar, Reinhold, Timo, Renie, Christian, Ribas, Ignasi, Ribeiro, Sergio, Ricciardi, Thiago Pereira, Rice, Ken, Richard, Olivier, Riello, Marco, Rieutord, Michel, Ripepi, Vincenzo, Rixon, Guy, Rockstein, Steve, Ortiz, José Ramón Rodón, Rodríguez, María Teresa Rodrigo, Amor, Alberto Rodríguez, Díaz, Luisa Fernanda Rodríguez, Garcia, Juan Pablo Rodriguez, Rodriguez-Gomez, Julio, Roehlly, Yannick, Roig, Fernando, Rojas-Ayala, Bárbara, Rolf, Tobias, Rørsted, Jakob Lysgaard, Rosado, Hugo, Rosotti, Giovanni, Roth, Olivier, Roth, Markus, Rousseau, Alex, Roxburgh, Ian, Roy, Fabrice, Royer, Pierre, Ruane, Kirk, Mastropasqua, Sergio Rufini, de Galarreta, Claudia Ruiz, Russi, Andrea, Saar, Steven, Saillenfest, Melaine, Salaris, Maurizio, Salmon, Sebastien, Saltas, Ippocratis, Samadi, Réza, Samadi, Aunia, Samra, Dominic, da Silva, Tiago Sanches, Carrasco, Miguel Andrés Sánchez, Santerne, Alexandre, Pé, Amaia Santiago, Santoli, Francesco, Santos, ngela R. G., Mesa, Rosario Sanz, Sarro, Luis Manuel, Scandariato, Gaetano, Schäfer, Martin, Schlafly, Edward, Schmider, François-Xavier, Schneider, Jean, Schou, Jesper, Schunker, Hannah, Schwarzkopf, Gabriel Jörg, Serenelli, Aldo, Seynaeve, Dries, Shan, Yutong, Shapiro, Alexander, Shipman, Russel, Sicilia, Daniela, sanmartin, Maria Angeles Sierra, Sigot, Axelle, Silliman, Kyle, Silvotti, Roberto, Simon, Attila E., Napoli, Ricardo Simoyama, Skarka, Marek, Smalley, Barry, Smiljanic, Rodolfo, Smit, Samuel, Smith, Alexis, Smith, Leigh, Snellen, Ignas, Sódor, Ádám, Sohl, Frank, Solanki, Sami K., Sortino, Francesca, Sousa, Sérgio, Southworth, John, Souto, Diogo, Sozzetti, Alessandro, Stamatellos, Dimitris, Stassun, Keivan, Steller, Manfred, Stello, Dennis, Stelzer, Beate, Stiebeler, Ulrike, Stokholm, Amalie, Storelvmo, Trude, Strassmeier, Klaus, Strøm, Paul Anthony, Strugarek, Antoine, Sulis, Sophia, vanda, Michal, Szabados, László, Szabó, Róbert, Szabó, Gyula M., Szuszkiewicz, Ewa, Talens, Geert Jan, Teti, Daniele, Theisen, Tom, Thévenin, Frédéric, Thoul, Anne, Tiphene, Didier, Titz-Weider, Ruth, Tkachenko, Andrew, Tomecki, Daniel, Tonfat, Jorge, Tosi, Nicola, Trampedach, Regner, Traven, Gregor, Triaud, Amaury, Trønnes, Reidar, Tsantaki, Maria, Tschentscher, Matthias, Turin, Arnaud, Tvaruzka, Adam, Ulmer, Bernd, Ulmer-Moll, Solène, Ulusoy, Ceren, Umbriaco, Gabriele, Valencia, Diana, Valentini, Marica, Valio, Adriana, Guijarro, Ángel Luis Valverde, Van Eylen, Vincent, Van Grootel, Valerie, van Kempen, Tim A., Van Reeth, Timothy, Van Zelst, Iris, Vandenbussche, Bart, Vasiliou, Konstantinos, Vasilyev, Valeriy, de Mascarenhas, David Vaz, Vazan, Allona, Nunez, Marina Vela, Velloso, Eduardo Nunes, Ventura, Rita, Ventura, Paolo, Venturini, Julia, Trallero, Isabel Vera, Veras, Dimitri, Verdugo, Eva, Verma, Kuldeep, Vibert, Didier, Martinez, Tobias Vicanek, Vida, Krisztián, Vigan, Arthur, Villacorta, Antonio, Villaver, Eva, Aparicio, Marcos Villaverde, Viotto, Valentina, Vorobyov, Eduard, Vorontsov, Sergey, Wagner, Frank W., Walloschek, Thomas, Walton, Nicholas, Walton, Dave, Wang, Haiyang, Waters, Rens, Watson, Christopher, Wedemeyer, Sven, Weeks, Angharad, Weingrill, Jörg, Weiss, Annita, Wendler, Belinda, West, Richard, Westerdorff, Karsten, Westphal, Pierre-Amaury, Wheatley, Peter, White, Tim, Whittaker, Amadou, Wickhusen, Kai, Wilson, Thomas, Windsor, James, Winter, Othon, Winther, Mark Lykke, Winton, Alistair, Witteck, Ulrike, Witzke, Veronika, Woitke, Peter, Wolter, David, Wuchterl, Günther, Wyatt, Mark, Yang, Dan, Yu, Jie, Sanchez, Ricardo Zanmar, Osorio, María Rosa Zapatero, Zechmeister, Mathias, Zhou, Yixiao, Ziemke, Claas, and Zwintz, Konstanze

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

PLATO (PLAnetary Transits and Oscillations of stars) is ESA's M3 mission designed to detect and characterise extrasolar planets and perform asteroseismic monitoring of a large number of stars. PLATO will detect small planets (down to <2 R_(Earth)) around bright stars (<11 mag), including terrestrial planets in the habitable zone of solar-like stars. With the complement of radial velocity observations from the ground, planets will be characterised for their radius, mass, and age with high accuracy (5 %, 10 %, 10 % for an Earth-Sun combination respectively). PLATO will provide us with a large-scale catalogue of well-characterised small planets up to intermediate orbital periods, relevant for a meaningful comparison to planet formation theories and to better understand planet evolution. It will make possible comparative exoplanetology to place our Solar System planets in a broader context. In parallel, PLATO will study (host) stars using asteroseismology, allowing us to determine the stellar properties with high accuracy, substantially enhancing our knowledge of stellar structure and evolution. The payload instrument consists of 26 cameras with 12cm aperture each. For at least four years, the mission will perform high-precision photometric measurements. Here we review the science objectives, present PLATO's target samples and fields, provide an overview of expected core science performance as well as a description of the instrument and the mission profile at the beginning of the serial production of the flight cameras. PLATO is scheduled for a launch date end 2026. This overview therefore provides a summary of the mission to the community in preparation of the upcoming operational phases.

Published
2024

10. The LiteBIRD mission to explore cosmic inflation

Author

Ghigna, T., Adler, A., Aizawa, K., Akamatsu, H., Akizawa, R., Allys, E., Anand, A., Aumont, J., Austermann, J., Azzoni, S., Baccigalupi, C., Ballardini, M., Banday, A. J., Barreiro, R. B., Bartolo, N., Basak, S., Basyrov, A., Beckman, S., Bersanelli, M., Bortolami, M., Bouchet, F., Brinckmann, T., Campeti, P., Carinos, E., Carones, A., Casas, F. J., Cheung, K., Chinone, Y., Clermont, L., Columbro, F., Coppolecchia, A., Curtis, D., de Bernardis, P., de Haan, T., de la Hoz, E., De Petris, M., Della Torre, S., Monache, G. Delle, Di Giorgi, E., Dickinson, C., Diego-Palazuelos, P., García, J. J. Díaz, Dobbs, M., Dotani, T., D'Alessandro, G., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Farias, N., Ferreira, E., Franceschet, C., Fuskeland, U., Galloni, G., Galloway, M., Ganga, K., Gerbino, M., Gervasi, M., Génova-Santos, R. T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., González, R. González, Grandsire, L., Gruppuso, A., Halverson, N. W., Hargrave, P., Harper, S. E., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Herranz, D., Hivon, E., Hlozek, R. A., Hoang, T. D., Hubmayr, J., Ichiki, K., Ikuma, K., Ishino, H., Jaehnig, G., Jost, B., Kohri, K., Konishi, K., Lamagna, L., Lattanzi, M., Leloup, C., Levrier, F., Lonappan, A. I., Luzzi, G., Macias-Perez, J., Maffei, B., Marchitelli, E., Martínez-González, E., Masi, S., Matarrese, S., Matsumura, T., Micheli, S., Migliaccio, M., Monelli, M., Montier, L., Morgante, G., Mousset, L., Nagano, Y., Nagata, R., Natoli, P., Novelli, A., Noviello, F., Obata, I., Occhiuzzi, A., Odagiri, K., Omae, R., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Patanchon, G., Pavlidou, V., Piacentini, F., Piat, M., Piccirilli, G., Pinchera, M., Pisano, G., Porcelli, L., Raffuzzi, N., Raum, C., Remazeilles, M., Ritacco, A., Rubino-Martin, J., Ruiz-Granda, M., Sakurai, Y., Savini, G., Scott, D., Sekimoto, Y., Shiraishi, M., Signorelli, G., Stever, S. L., Sullivan, R. M., Suzuki, A., Takaku, R., Takakura, H., Takakura, S., Tartari, Y. Takase. A., Tassis, K., Thompson, K. L., Tomasi, M., Tristram, M., Tucker, C., Vacher, L., van Tent, B., Vielva, P., Watanuki, K., Wehus, I. K., Westbrook, B., Weymann-Despres, G., Winter, B., Wollack, E. J., Zacchei, A., Zannoni, M., Zhou, Y., and Collaboration, the LiteBIRD

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, Physics - Instrumentation and Detectors
Abstract

LiteBIRD, the next-generation cosmic microwave background (CMB) experiment, aims for a launch in Japan's fiscal year 2032, marking a major advancement in the exploration of primordial cosmology and fundamental physics. Orbiting the Sun-Earth Lagrangian point L2, this JAXA-led strategic L-class mission will conduct a comprehensive mapping of the CMB polarization across the entire sky. During its 3-year mission, LiteBIRD will employ three telescopes within 15 unique frequency bands (ranging from 34 through 448 GHz), targeting a sensitivity of 2.2\,$\mu$K-arcmin and a resolution of 0.5$^\circ$ at 100\,GHz. Its primary goal is to measure the tensor-to-scalar ratio $r$ with an uncertainty $\delta r = 0.001$, including systematic errors and margin. If $r \geq 0.01$, LiteBIRD expects to achieve a $>5\sigma$ detection in the $\ell=$2-10 and $\ell=$11-200 ranges separately, providing crucial insight into the early Universe. We describe LiteBIRD's scientific objectives, the application of systems engineering to mission requirements, the anticipated scientific impact, and the operations and scanning strategies vital to minimizing systematic effects. We will also highlight LiteBIRD's synergies with concurrent CMB projects., Comment: 23 pages, 9 figures, 1 table, SPIE Astronomical Telescopes + Instrumentation 2024

Published
2024

13. Post-quantum Asynchronous Remote Key Generation for FIDO2

Author

Brendel, Jacqueline, Clermont, Sebastian, Fischlin, Marc, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Chung, Kai-Min, editor, and Sasaki, Yu, editor

Published
2025
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14. Bevacizumab-based Chemotherapy Adapted to Bevacizumab Pharmacokinetics in 1st-line Treatment (PHARBEVACOL)

Author

CHU DE BESANCON, Gustave Roussy, Cancer Campus, Grand Paris, CHU de Clermont-Ferrand, CHU de Reims, CHU de Brest, AP-HP, Hôpital Pitié- Salpétrière, CHU de Rouen, Poitiers University Hospital, Institut Paoli-Calmettes, Rennes University Hospital, University Hospital, Toulouse, AP-HP, Hôpital Saint-Louis, HCL Hôpital Edouard Hériot, Centre Hospitalier Universitaire Dijon, Nantes University Hospital, Centre Hospitalier Universitaire, Amiens, Hôpital Privé Jean Mermoz, AP-HP, Hôpital Henri Mondor, AP-HP, Hôpital Paul Brousse, CHG de St-Malo, Polyclinique de Blois, University Hospital, Caen, and CHU de Nancy

Published
2024

16. BRAINI-2 Elderly Mild TBI European Study (BRAINI2ELDER)

Author

Technical University of Munich, University Hospital, Grenoble, University Hospital, Clermont-Ferrand, Hospital Vall d'Hebron, BioMérieux, EIT Health, and Alfonso Lagares Gómez-Abascal, Department of Neurosurgery, Head

Published
2024

17. Physical Activity and Sedentary Behavior During Pregnancy (PREGMOUV)

Author

Réseau de Santé en Périnatalité d'Auvergne, ASM Omnisports - Pôle Sport-Santé, Office Municipal du Sport - Espace Sport Santé, Observatoire national de l'activité physique et de la sédentarité, Ville de Clermont-Ferrand, and Ministère de la Santé et de la Prévention

Published
2024

18. LiteBIRD Science Goals and Forecasts: Primordial Magnetic Fields

Author

Paoletti, D., Rubino-Martin, J., Shiraishi, M., Molinari, D., Chluba, J., Finelli, F., Baccigalupi, C., Errard, J., Gruppuso, A., Lonappan, A. I., Tartari, A., Allys, E., Anand, A., Aumont, J., Ballardini, M., Banday, A. J., Barreiro, R. B., Bartolo, N., Bersanelli, M., Bortolami, M., Brinckmann, T., Calabrese, E., Campeti, P., Carones, A., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., Della Torre, S., Diego-Palazuelos, P., Eriksen, H. K., Fuskeland, U., Galloni, G., Galloway, M., Gerbino, M., Gervasi, M., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., Grupp, F., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Hivon, E., Ichiki, K., Ishino, H., Kohri, K., Komatsu, E., Krachmalnicoff, N., Lamagna, L., Lattanzi, M., Lembo, M., Levrier, F., López-Caniego, M., Luzzi, G., Martínez-González, E., Masi, S., Matarrese, S., Micheli, S., Migliaccio, M., Monelli, M., Montier, L., Morgante, G., Mousset, L., Nagata, R., Namikawa, T., Natoli, P., Novelli, A., Obata, I., Occhiuzzi, A., Odagiri, K., Pagano, L., Paiella, A., Pascual-Cisneros, G., Piacentini, F., Piccirilli, G., Remazeilles, M., Ritacco, A., Ruiz-Granda, M., Sakurai, Y., Scott, D., Stever, S. L., Sullivan, R. M., Takase, Y., Tassis, K., Terenzi, L., Tristram, M., Vacher, L., van Tent, B., Vielva, P., Wehus, I. K., Weymann-Despres, G., Zannoni, M., and Zhou, Y.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present detailed forecasts for the constraints on primordial magnetic fields (PMFs) that will be obtained with the LiteBIRD satellite. The constraints are driven by the effects of PMFs on the CMB anisotropies: the gravitational effects of magnetically-induced perturbations; the effects on the thermal and ionization history of the Universe; the Faraday rotation imprint on the CMB polarization; and the non-Gaussianities induced in polarization anisotropies. LiteBIRD represents a sensitive probe for PMFs and by exploiting all the physical effects, it will be able to improve the current limit coming from Planck. In particular, thanks to its accurate $B$-mode polarization measurement, LiteBIRD will improve the constraints on infrared configurations for the gravitational effect, giving $B_{\rm 1\,Mpc}^{n_{\rm B} =-2.9} < 0.8$ nG at 95% C.L., potentially opening the possibility to detect nanogauss fields with high significance. We also observe a significant improvement in the limits when marginalized over the spectral index, $B_{1\,{\rm Mpc}}^{\rm marg}< 2.2$ nG at 95% C.L. From the thermal history effect, which relies mainly on $E$-mode polarization data, we obtain a significant improvement for all PMF configurations, with the marginalized case, $\sqrt{\langle B^2\rangle}^{\rm marg}<0.50$ nG at 95% C.L. Faraday rotation constraints will take advantage of the wide frequency coverage of LiteBIRD and the high sensitivity in $B$ modes, improving the limits by orders of magnitude with respect to current results, $B_{1\,{\rm Mpc}}^{n_{\rm B} =-2.9} < 3.2$ nG at 95% C.L. Finally, non-Gaussianities of the $B$-mode polarization can probe PMFs at the level of 1 nG, again significantly improving the current bounds from Planck. Altogether our forecasts represent a broad collection of complementary probes, providing conservative limits on PMF characteristics that will be achieved with LiteBIRD., Comment: 51 pages, 24 figures, abstract shortened

Published
2024

19. Psychoeducation for Suicidal Behavior (PEPSUI)

Author

CHU Marius Lacroix, Lille, FRANCE, CHU Gabriel Montpied, Clermont Ferrand, FRANCE, CHU Pasteur, Nice, FRANCE, Centre Psychothérapique de Nancy, FRANCE, CHU Le Vinatier, Bron, FRANCE, CHU Albert Michallon, La Tronche, FRANCE, and CHU Tarnier, Paris, FRANCE

Published
2024

20. Helping Osteoarthritis Patients to Walk With NSAID (PERIPATEI)

Author

Plateforme d'Investigation Clinique, INSERM CIC1405, CHU de Clermont-Ferrand, France, Fondation Apicil, Médecine Physique et Réadaptation, CHU de Clermont-Ferrand, France, Médecine du Sport et Explorations Fonctionnelles, CHU de Clermont-Ferrand, France, Rhumatologie, CHU de Clermont-Ferrand, France, Direction de la Recherche Clinique et des Innovations, CHU de Clermont-Ferrand, France, SARL BOUCHARENC, Saint-Chély d'Apcher, France, Inserm U1107 ' Neuro-Dol ', Clermont-Ferrand, France, and Université Clermont-Auvergne, France

Published
2024

22. Evaluation of General Large Language Models in Contextually Assessing Semantic Concepts Extracted from Adult Critical Care Electronic Health Record Notes

Author

Liu, Darren, Ding, Cheng, Bold, Delgersuren, Bouvier, Monique, Lu, Jiaying, Shickel, Benjamin, Jabaley, Craig S., Zhang, Wenhui, Park, Soojin, Young, Michael J., Wainwright, Mark S., Clermont, Gilles, Rashidi, Parisa, Rosenthal, Eric S., Dimisko, Laurie, Xiao, Ran, Yoon, Joo Heung, Yang, Carl, and Hu, Xiao

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence, Computer Science - Software Engineering
Abstract

The field of healthcare has increasingly turned its focus towards Large Language Models (LLMs) due to their remarkable performance. However, their performance in actual clinical applications has been underexplored. Traditional evaluations based on question-answering tasks don't fully capture the nuanced contexts. This gap highlights the need for more in-depth and practical assessments of LLMs in real-world healthcare settings. Objective: We sought to evaluate the performance of LLMs in the complex clinical context of adult critical care medicine using systematic and comprehensible analytic methods, including clinician annotation and adjudication. Methods: We investigated the performance of three general LLMs in understanding and processing real-world clinical notes. Concepts from 150 clinical notes were identified by MetaMap and then labeled by 9 clinicians. Each LLM's proficiency was evaluated by identifying the temporality and negation of these concepts using different prompts for an in-depth analysis. Results: GPT-4 showed overall superior performance compared to other LLMs. In contrast, both GPT-3.5 and text-davinci-003 exhibit enhanced performance when the appropriate prompting strategies are employed. The GPT family models have demonstrated considerable efficiency, evidenced by their cost-effectiveness and time-saving capabilities. Conclusion: A comprehensive qualitative performance evaluation framework for LLMs is developed and operationalized. This framework goes beyond singular performance aspects. With expert annotations, this methodology not only validates LLMs' capabilities in processing complex medical data but also establishes a benchmark for future LLM evaluations across specialized domains.

Published
2024

23. Impact of beam far side-lobe knowledge in the presence of foregrounds for LiteBIRD

Author

Leloup, C., Patanchon, G., Errard, J., Franceschet, C., Gudmundsson, J. E., Henrot-Versillé, S., Imada, H., Ishino, H., Matsumura, T., Puglisi, G., Wang, W., Adler, A., Aumont, J., Aurlien, R., Baccigalupi, C., Ballardini, M., Banday, A. J., Barreiro, R. B., Bartolo, N., Basyrov, A., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Campeti, P., Carones, A., Carralot, F., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., de Haan, T., De Petris, M., Della Torre, S., Diego-Palazuelos, P., Eriksen, H. K., Finelli, F., Fuskeland, U., Galloni, G., Galloway, M., Georges, M., Gerbino, M., Gervasi, M., Génova-Santos, R. T., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., Gruppuso, A., Hazumi, M., Hergt, L. T., Herranz, D., Hivon, E., Hoang, T. D., Jost, B., Kohri, K., Krachmalnicoff, N., Lee, A. T., Lembo, M., Levrier, F., Lonappan, A. I., López-Caniego, M., Macias-Perez, J., Martínez-González, E., Masi, S., Matarrese, S., Micheli, S., Monelli, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Namikawa, T., Natoli, P., Novelli, A., Noviello, F., Obata, I., Odagiri, K., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Pavlidou, V., Piacentini, F., Piccirilli, G., Pisano, G., Polenta, G., Raffuzzi, N., Remazeilles, M., Ritacco, A., Rizzieri, A., Ruiz-Granda, M., Sakurai, Y., Shiraishi, M., Stever, S. L., Takase, Y., Tassis, K., Terenzi, L., Thompson, K. L., Tristram, M., Vacher, L., Vielva, P., Wehus, I. K., Weymann-Despres, G., Zannoni, M., and Zhou, Y.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present a study of the impact of an uncertainty in the beam far side-lobe knowledge on the measurement of the Cosmic Microwave Background $B$-mode signal at large scale. It is expected to be one of the main source of systematic effects in future CMB observations. Because it is crucial for all-sky survey missions to take into account the interplays between beam systematic effects and all the data analysis steps, the primary goal of this paper is to provide the methodology to carry out the end-to-end study of their effect for a space-borne CMB polarization experiment, up to the cosmological results in the form of a bias $\delta r$ on the tensor-to-scalar ratio $r$. LiteBIRD is dedicated to target the measurement of CMB primordial $B$ modes by reaching a sensitivity of $\sigma \left( r \right) \leq 10^{-3}$ assuming $r=0$. As a demonstration of our framework, we derive the relationship between the knowledge of the beam far side-lobes and the tentatively allocated error budget under given assumptions on design, simulation and component separation method. We assume no mitigation of the far side-lobes effect at any stage of the analysis pipeline. We show that $\delta r$ is mostly due to the integrated fractional power difference between the estimated beams and the true beams in the far side-lobes region, with little dependence on the actual shape of the beams, for low enough $\delta r$. Under our set of assumptions, in particular considering the specific foreground cleaning method we used, we find that the integrated fractional power in the far side-lobes should be known at a level as tight as $\sim 10^{-4}$, to achieve the required limit on the bias $\delta r < 1.9 \times 10^{-5}$. The framework and tools developed for this study can be easily adapted to provide requirements under different design, data analysis frameworks and for other future space-borne experiments beyond LiteBIRD.

Published
2023

24. LiteBIRD Science Goals and Forecasts: Improving Sensitivity to Inflationary Gravitational Waves with Multitracer Delensing

Author

Namikawa, T., Lonappan, A. I., Baccigalupi, C., Bartolo, N., Beck, D., Benabed, K., Challinor, A., Diego-Palazuelos, P., Errard, J., Farrens, S., Gruppuso, A., Krachmalnicoff, N., Migliaccio, M., Martínez-González, E., Pettorino, V., Piccirilli, G., Ruiz-Granda, M., Sherwin, B., Starck, J., Vielva, P., Akizawa, R., Anand, A., Aumont, J., Aurlien, R., Azzoni, S., Ballardini, M., Banday, A. J., Barreiro, R. B., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Calabrese, E., Campeti, P., Carones, A., Carralot, F., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., de Haan, T., De Petris, M., Della Torre, S., Di Giorgi, E., Eriksen, H. K., Finelli, F., Franceschet, C., Fuskeland, U., Galloni, G., Galloway, M., Georges, M., Gerbino, M., Gervasi, M., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Hivon, E., Kohri, K., Komatsu, E., Lamagna, L., Lattanzi, M., Leloup, C., Lembo, M., López-Caniego, M., Luzzi, G., Maffei, B., Masi, S., Massa, M., Matarrese, S., Matsumura, T., Micheli, S., Moggi, A., Monelli, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Nagata, R., Natoli, P., Novelli, A., Obata, I., Occhiuzzi, A., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Pavlidou, V., Piacentini, F., Pinchera, M., Pisano, G., Polenta, G., Puglisi, G., Remazeilles, M., Ritacco, A., Rizzieri, A., Rubino-Martin, J., Sakurai, Y., Scott, D., Shiraishi, M., Signorelli, G., Stever, S. L., Takase, Y., Tanimura, H., Tartari, A., Tassis, K., Terenzi, L., Tristram, M., Vacher, L., van Tent, B., Wehus, I. K., Weymann-Despres, G., Zannoni, M., and Zhou, Y.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We estimate the efficiency of mitigating the lensing $B$-mode polarization, the so-called delensing, for the $LiteBIRD$ experiment with multiple external data sets of lensing-mass tracers. The current best bound on the tensor-to-scalar ratio, $r$, is limited by lensing rather than Galactic foregrounds. Delensing will be a critical step to improve sensitivity to $r$ as measurements of $r$ become more and more limited by lensing. In this paper, we extend the analysis of the recent $LiteBIRD$ forecast paper to include multiple mass tracers, i.e., the CMB lensing maps from $LiteBIRD$ and CMB-S4-like experiment, cosmic infrared background, and galaxy number density from $Euclid$- and LSST-like survey. We find that multi-tracer delensing will further improve the constraint on $r$ by about $20\%$. In $LiteBIRD$, the residual Galactic foregrounds also significantly contribute to uncertainties of the $B$-modes, and delensing becomes more important if the residual foregrounds are further reduced by an improved component separation method., Comment: 21 pages, 7 figures

Published
2023
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25. LiteBIRD Science Goals and Forecasts: A full-sky measurement of gravitational lensing of the CMB

Author

Lonappan, A. I., Namikawa, T., Piccirilli, G., Diego-Palazuelos, P., Ruiz-Granda, M., Migliaccio, M., Baccigalupi, C., Bartolo, N., Beck, D., Benabed, K., Challinor, A., Errard, J., Farrens, S., Gruppuso, A., Krachmalnicoff, N., Martínez-González, E., Pettorino, V., Sherwin, B., Starck, J., Vielva, P., Akizawa, R., Anand, A., Aumont, J., Aurlien, R., Azzoni, S., Ballardini, M., Banday, A. J., Barreiro, R. B., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Calabrese, E., Campeti, P., Carones, A., Carralot, F., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., De Petris, M., Della Torre, S., Di Giorgi, E., Eriksen, H. K., Finelli, F., Franceschet, C., Fuskeland, U., Galloni, G., Galloway, M., Georges, M., Gerbino, M., Gervasi, M., Génova-Santos, R. T., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Hivon, E., Kohri, K., Komatsu, E., Lamagna, L., Lattanzi, M., Leloup, C., Lembo, M., López-Caniego, M., Luzzi, G., Macias-Perez, J., Maffei, B., Masi, S., Massa, M., Matarrese, S., Matsumura, T., Micheli, S., Moggi, A., Monelli, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Nagata, R., Natoli, P., Novelli, A., Obata, I., Occhiuzzi, A., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Pavlidou, V., Piacentini, F., Pinchera, M., Pisano, G., Polenta, G., Puglisi, G., Remazeilles, M., Ritacco, A., Rizzieri, A., Sakurai, Y., Scott, D., Shiraishi, M., Signorelli, G., Stever, S. L., Takase, Y., Tanimura, H., Tartari, A., Tassis, K., Terenzi, L., Tristram, M., Vacher, L., van Tent, B., Wehus, I. K., Weymann-Despres, G., Zannoni, M., and Zhou, Y.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We explore the capability of measuring lensing signals in $LiteBIRD$ full-sky polarization maps. With a $30$ arcmin beam width and an impressively low polarization noise of $2.16\,\mu$K-arcmin, $LiteBIRD$ will be able to measure the full-sky polarization of the cosmic microwave background (CMB) very precisely. This unique sensitivity also enables the reconstruction of a nearly full-sky lensing map using only polarization data, even considering its limited capability to capture small-scale CMB anisotropies. In this paper, we investigate the ability to construct a full-sky lensing measurement in the presence of Galactic foregrounds, finding that several possible biases from Galactic foregrounds should be negligible after component separation by harmonic-space internal linear combination. We find that the signal-to-noise ratio of the lensing is approximately $40$ using only polarization data measured over $90\%$ of the sky. This achievement is comparable to $Planck$'s recent lensing measurement with both temperature and polarization and represents a four-fold improvement over $Planck$'s polarization-only lensing measurement. The $LiteBIRD$ lensing map will complement the $Planck$ lensing map and provide several opportunities for cross-correlation science, especially in the northern hemisphere.

Published
2023
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26. LiteBIRD Science Goals and Forecasts. A Case Study of the Origin of Primordial Gravitational Waves using Large-Scale CMB Polarization

Author

Campeti, P., Komatsu, E., Baccigalupi, C., Ballardini, M., Bartolo, N., Carones, A., Errard, J., Finelli, F., Flauger, R., Galli, S., Galloni, G., Giardiello, S., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Kohri, K., Leloup, C., Lesgourgues, J., Macias-Perez, J., Martínez-González, E., Matarrese, S., Matsumura, T., Montier, L., Namikawa, T., Paoletti, D., Poletti, D., Remazeilles, M., Shiraishi, M., van Tent, B., Tristram, M., Vacher, L., Vittorio, N., Weymann-Despres, G., Anand, A., Aumont, J., Aurlien, R., Banday, A. J., Barreiro, R. B., Basyrov, A., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Calabrese, E., Carralot, F., Casas, F. J., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., De Petris, M., Della Torre, S., Di Giorgi, E., Diego-Palazuelos, P., Eriksen, H. K., Franceschet, C., Fuskeland, U., Galloway, M., Georges, M., Gerbino, M., Gervasi, M., Ghigna, T., Gimeno-Amo, C., Gjerløw, E., Gruppuso, A., Gudmundsson, J., Krachmalnicoff, N., Lamagna, L., Lattanzi, M., Lembo, M., Lonappan, A. I., Masi, S., Massa, M., Micheli, S., Moggi, A., Monelli, M., Morgante, G., Mot, B., Mousset, L., Nagata, R., Natoli, P., Novelli, A., Obata, I., Pagano, L., Paiella, A., Pavlidou, V., Piacentini, F., Pinchera, M., Pisano, G., Puglisi, G., Raffuzzi, N., Ritacco, A., Rizzieri, A., Ruiz-Granda, M., Savini, G., Scott, D., Signorelli, G., Stever, S. L., Stutzer, N., Sullivan, R. M., Tartari, A., Tassis, K., Terenzi, L., Thompson, K. L., Vielva, P., Wehus, I. K., and Zhou, Y.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology
Abstract

We study the possibility of using the $LiteBIRD$ satellite $B$-mode survey to constrain models of inflation producing specific features in CMB angular power spectra. We explore a particular model example, i.e. spectator axion-SU(2) gauge field inflation. This model can source parity-violating gravitational waves from the amplification of gauge field fluctuations driven by a pseudoscalar "axionlike" field, rolling for a few e-folds during inflation. The sourced gravitational waves can exceed the vacuum contribution at reionization bump scales by about an order of magnitude and can be comparable to the vacuum contribution at recombination bump scales. We argue that a satellite mission with full sky coverage and access to the reionization bump scales is necessary to understand the origin of the primordial gravitational wave signal and distinguish among two production mechanisms: quantum vacuum fluctuations of spacetime and matter sources during inflation. We present the expected constraints on model parameters from $LiteBIRD$ satellite simulations, which complement and expand previous studies in the literature. We find that $LiteBIRD$ will be able to exclude with high significance standard single-field slow-roll models, such as the Starobinsky model, if the true model is the axion-SU(2) model with a feature at CMB scales. We further investigate the possibility of using the parity-violating signature of the model, such as the $TB$ and $EB$ angular power spectra, to disentangle it from the standard single-field slow-roll scenario. We find that most of the discriminating power of $LiteBIRD$ will reside in $BB$ angular power spectra rather than in $TB$ and $EB$ correlations., Comment: 22 pages, 13 figures. Submitted to JCAP

Published
2023

28. Genomic perspective on the bacillus causing paratyphoid B fever

Author

Hawkey, Jane, Frézal, Lise, Tran Dien, Alicia, Zhukova, Anna, Brown, Derek, Chattaway, Marie Anne, Simon, Sandra, Izumiya, Hidemasa, Fields, Patricia I., De Lappe, Niall, Kaftyreva, Lidia, Xu, Xuebin, Isobe, Junko, Clermont, Dominique, Njamkepo, Elisabeth, Akeda, Yukihiro, Issenhuth-Jeanjean, Sylvie, Makarova, Mariia, Wang, Yanan, Hunt, Martin, Jenkins, Brent M., Ravel, Magali, Guibert, Véronique, Serre, Estelle, Matveeva, Zoya, Fabre, Laëtitia, Cormican, Martin, Yue, Min, Zhu, Baoli, Morita, Masatomo, Iqbal, Zamin, Silva Nodari, Carolina, Pardos de la Gandara, Maria, and Weill, François-Xavier

Published
2024
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31. Farnesyltransferase inhibition overcomes oncogene-addicted non-small cell lung cancer adaptive resistance to targeted therapies

Author

Figarol, Sarah, Delahaye, Célia, Gence, Rémi, Doussine, Aurélia, Cerapio, Juan Pablo, Brachais, Mathylda, Tardy, Claudine, Béry, Nicolas, Asslan, Raghda, Colinge, Jacques, Villemin, Jean-Philippe, Maraver, Antonio, Ferrer, Irene, Paz-Ares, Luis, Kessler, Linda, Burrows, Francis, Lajoie-Mazenc, Isabelle, Dongay, Vincent, Morin, Clara, Florent, Amélie, Pagano, Sandra, Taranchon-Clermont, Estelle, Casanova, Anne, Pradines, Anne, Mazieres, Julien, Favre, Gilles, and Calvayrac, Olivier

Published
2024
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37. Development of Ovarian Tissue Autograft in Order to Restore Ovarian Function (DATOR)

Author

CHU de Reims, University Hospital, Marseille, Nantes University Hospital, University Hospital, Lille, Central Hospital, Nancy, France, University Hospital, Toulouse, University Hospital, Grenoble, University Hospital, Bordeaux, CMCO SIHCUS, Schiltingheim, University Hospital, Rouen, University Hospital, Limoges, University Hospital, Angers, Centre Hospitalier Universitaire de Nice, Tenon Hospital, Paris, Poissy-Saint Germain Hospital, Hôpital Jean Verdier, University Hospital, Clermont-Ferrand, and Hopital Antoine Beclere

Published
2024

38. Covid-19 Respiratory Sequelae French Cohort (PNEUMOCOVID)

Author

Cabinet Medical valenciennes, CH Aix, hopital privé de bois bernard, Clinique La Croix du Sud, University Hospital, Bordeaux, Hopital Forcilles, Hopital d'instructions des armées, Hôpital Européen Marseille, Rennes University Hospital, Clinique Saint Augustin, Delafontaine Hospital, Centre Hospitalier Universitaire de Saint Etienne, Centre Hospitalier de Troyes, Centre Hospitalier le Mans, University Hospital, Clermont-Ferrand, and University Hospital, Tours

Published
2024

42. Cohort profile: the longitudinal National Growth and Health Study (NGHS) of black and white girls from Northern California tracking how behavioural and psychosocial risk factors predict cardiovascular risk and biological ageing in midlife and in offspring

Author

Laraia, Barbara, Brownell, Kristy, Friebur, Robin, Perera, Rachel, Brown, Erika, Mayer, Stefanie E, Feng, Ingrid, Clermont, Sabrina, Ritchie, Lorrene D, and Epel, Elissa

Subjects
Biomedical and Clinical Sciences, Public Health, Health Sciences, Childhood Obesity, Health Disparities, Minority Health, Clinical Research, Heart Disease, Cardiovascular, Pediatric, Women's Health, Prevention, Behavioral and Social Science, Aging, Obesity, Nutrition, Social Determinants of Health, Mental health, Good Health and Well Being, Adolescent, Adult, Child, Child, Preschool, Female, Humans, Male, Young Adult, Biomarkers, Body Mass Index, California, Cardiovascular Diseases, Heart Disease Risk Factors, Longitudinal Studies, Risk Factors, Thinness, White, Black or African American, EPIDEMIOLOGIC STUDIES, Health Equity, PUBLIC HEALTH, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

PurposeThe National Heart, Lung and Blood Institute Growth and Health Study (NGHS) prospectively collected anthropometric, biospecimens, clinical, health behaviour and psychosocial measures associated with cardiovascular disease from childhood to young adulthood. The aim of the current study was to assess the impact of stress, dysregulated eating and social genomic biomarkers on cardiometabolic risk factors among the original participants now in midlife and their children.ParticipantsBeginning in 1987-1988, NGHS recruited black and white girls (age 9-10 years) from socioeconomically diverse backgrounds from from three sites: Cincinnati, Ohio; Washington, DC; and Western Contra Costa County, California (N=2379) and followed them for 10 years. The study maintained an 89% retention rate. The current study is 30 years after the start of the original study and focused on the participants of California (n=887) and their children aged 2-17 years. We re-enrolled 624 of 852 eligible participants (73%): 49.2% black and 50.8% white. The mean age was 39.5 years. Among the 645 eligible biological children, 553 were enrolled; 49% black and 51% white, with 51.5% girls and 48.5% boys. The mean age was 9.3 years.Findings to dateLongitudinal analysis of adolescent drive for thinness predicted higher scores for drive for thinness during midlife, which was indirectly associated with greater adult body mass index through adult drive for thinness. Latent trajectory modelling of adolescent growth over 10 years found that women with persistently high weight trajectory had twice the odds of having children who met the definition for obesity compared with the persistently normal group, adjusting for adult weight.Future plansNew studies on neighbourhood socioeconomic status, food insecurity and additional biomarkers of chronic stress, microbiome and accelerated ageing (ie, telomere length and epigenetic clock) are underway. We are developing a 10-year follow-up to understand changes in ageing biomarkers of the participants and their children.Trial registration numberNCT00005132.

Published
2023

43. Treating amyotrophic lateral sclerosis with allogeneic Schwann cell–derived exosomal vesicles: a case report

Author

Pascal J. Goldschmidt-Clermont, Aisha Khan, George Jimsheleishvili, Patricia Graham, Adriana Brooks, Risset Silvera, Alexander J.P. Goldschmidt, Damien D. Pearse, W. Dalton Dietrich, Allan D. Levi, and James D. Guest

Subjects
allogeneic, amyotrophic lateral sclerosis, exosomes, infusion, neuromuscular junction, schwann cell, Neurology. Diseases of the nervous system, RC346-429
Abstract

Schwann cells are essential for the maintenance and function of motor neurons, axonal networks, and the neuromuscular junction. In amyotrophic lateral sclerosis, where motor neuron function is progressively lost, Schwann cell function may also be impaired. Recently, important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been reported. This case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles, marking, to our knowledge, the first instance of such treatment. An 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral sclerosis. After initial diagnosis, the patient underwent a combination of generic riluzole, sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis, and taurursodiol. The patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron function. We confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired (senescent) and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles, cultured expanded from a cadaver donor improved their growth capacity in vitro. After a period of observation lasting 10 weeks, during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored, the patient received weekly consecutive infusions of 1.54 × 1012 (×2), and then consecutive infusions of 7.5 × 1012 (×6) allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered saline. None of the infusions were associated with adverse events such as infusion reactions (allergic or otherwise) or changes in vital signs. Clinical lab serum neurofilament and cytokine levels measured prior to each infusion varied somewhat without a clear trend. A more sensitive in-house assay suggested possible inflammasome activation during the disease course. A trend for clinical stabilization was observed during the infusion period. Our study provides a novel approach to address impaired Schwann cells and possibly motor neuron function in patients with amyotrophic lateral sclerosis using allogeneic Schwann cell-derived exosomal vesicles. Initial findings suggest that this approach is safe.

Published
2025
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44. Effect of Long-term Carvedilol to Prevent Decompensation or Death in Patients With Asymptomatic Child-Pugh A5 to B8 Cirrhosis and Clinically Significant Portal Hypertension: a Multicenter Double-blind Randomized Control Trial (CARVECIR)

Author

Centre Hospitalier Universitaire Amiens Picardie, Centre Hospitalier Universitaire Angers, Assistance Publique Hopitaux Paris BEAUJON, Centre Hospitalier Universitaire Caen, Centre Hospitalier intercommunal de Créteil, Hospices Civils de Lyon, Centre Hospitalier Universitaire Grenoble, Centre Hospitalier Universitaire Haut Lévêque, Centre Hospitalier Régional Universitaire Lille, Centre Hospitalier Universitaire Jean Minjoz, Assistance Publique Hopitaux Paris AVICENNE, Centre Hospitalier Universitaire Clermont Ferrand, Assistance Publique Hopitaux Paris LA PITIE SALPETRIERE, Centre Hospitalier Universitaire Pontchaillou, Assistance Publique Hopitaux Paris ST ANTOINE, Assistance Publique Hopitaux Paris PAUL BROUSSE, University Hospital, Montpellier, Assistance Publique Hopitaux Paris HENRI MONDOR, Centre Hospitaliser Départemental de Vendée, Nantes University Hospital, Centre Hospitalier Universitaire Dijon, CHU de Reims, Hôpitaux Universitaires de Strasbourg, and University Hospital, Toulouse

Published
2024

47. Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries (GUEST)

Author

BioMérieux, Assistance Publique - Hôpitaux de Paris, University Hospital, Clermont-Ferrand, Hospices Civils de Lyon, Poitiers University Hospital, University Hospital, Angers, Centre Hospitalier Universitaire de Nīmes, Centre Hospitalier Universitaire de Nice, Nantes University Hospital, University Hospital, Montpellier, Centre Hospitalier Universitaire Dijon, University Hospital, Grenoble, Fondation Hôpital Saint-Joseph, and CHU de Tours

Published
2024

48. Randomized trial of bilateral gene therapy injection for m.11778G>A MT-ND4 Leber optic neuropathy

Author

Newman, Nancy J, Yu-Wai-Man, Patrick, Subramanian, Prem S, Moster, Mark L, Wang, An-Guor, Donahue, Sean P, Leroy, Bart P, Carelli, Valerio, Biousse, Valerie, Vignal-Clermont, Catherine, Sergott, Robert C, Sadun, Alfredo A, Rebolleda Fernández, Gema, Chwalisz, Bart K, Banik, Rudrani, Bazin, Fabienne, Roux, Michel, Cox, Eric D, Taiel, Magali, Sahel, José-Alain, Giulia, Amore, Shweta, Anand, Rudrani, Banik, Piero, Barboni, Valérie, Biousse, Hayley, Boston, Asma, Burale, Michele, Carbonelli, Valerio, Carelli, Celia, Chen, Hui-Chen, Cheng, Steve, Cho, Manuela, Contin, Pietro, D’Agati, DeBusk, Adam A, Julie, De Zaeytijd, Jannah, Dobbs, Lindreth, DuBois, Simona, Esposti, Alcides, Fernandes Filho, Elizabeth, Fortin, Sapna, Gangaputra, Deborah, Gibbs, François, Girmens Jean, Rabih, Hage, Haller, Julia A, Gad, Heilweil, George Baker, Hubbard III, Jeong-Min, Hwang, Laia, Jaumendreu Urquijo, Neringa, Jurkute, Rustum, Karanjia, Wahiba, Khemliche, La Chiara, Morgia, Maria, Massini, Marc, Mathias, Memon, Muhammad A, Susan, Mohamed, Muñoz Negrete, Francisco J, Ghazala, O’Keefe, Shriji, Patel, Paula, Pecen, Peragallo, Jason H, Lise, Plaine, Mary, Preston, Gema, Rebolleda Fernández, Martina, Romagnoli, José-Alain, Sahel, Melissa, SantaMaria, Chuanbin, Sun, Katy, Tai, Heather, Tollis, Irena, Tsui, Tucker, William R, Catherine, Vignal-Clermont, An-Guor, Wang, Saige, Wilkins, and Patrick, Yu-Wai-Man

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Clinical Research, Genetics, Neurosciences, Clinical Trials and Supportive Activities, Eye Disease and Disorders of Vision, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Eye, Humans, DNA, Mitochondrial, Genetic Therapy, Inflammation, Mutation, Optic Atrophy, Hereditary, Leber, LHON REFLECT Study Group, NADH dehydrogenase 4, leber hereditary optic neuropathy, lenadogene nolparvovec, mitochondrial DNA, recombinant adeno-associated virus vector 2, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

Leber hereditary optic neuropathy (LHON) is an important example of mitochondrial blindness with the m.11778G>A mutation in the MT-ND4 gene being the most common disease-causing mtDNA variant worldwide. The REFLECT phase 3 pivotal study is a randomized, double-masked, placebo-controlled trial investigating the efficacy and safety of bilateral intravitreal injection of lenadogene nolparvovec in patients with a confirmed m.11778G>A mutation, using a recombinant adeno-associated virus vector 2, serotype 2 (rAAV2/2-ND4). The first-affected eye received gene therapy; the fellow (affected/not-yet-affected) eye was randomly injected with gene therapy or placebo. The primary end point was the difference in change from baseline of best-corrected visual acuity (BCVA) in second-affected/not-yet-affected eyes treated with lenadogene nolparvovec versus placebo at 1.5 years post-treatment, expressed in logarithm of the minimal angle of resolution (LogMAR). Forty-eight patients were treated bilaterally and 50 unilaterally. At 1.5 years, the change from baseline in BCVA was not statistically different between second-affected/not-yet-affected eyes receiving lenadogene nolparvovec and placebo (primary end point). A statistically significant improvement in BCVA was reported from baseline to 1.5 years in lenadogene nolparvovec-treated eyes: -0.23 LogMAR for the first-affected eyes of bilaterally treated patients (P < 0.01); and -0.15 LogMAR for second-affected/not-yet-affected eyes of bilaterally treated patients and the first-affected eyes of unilaterally treated patients (P < 0.05). The mean improvement in BCVA from nadir to 1.5 years was -0.38 (0.052) LogMAR and -0.33 (0.052) LogMAR in first-affected and second-affected/not-yet-affected eyes treated with lenadogene nolparvovec, respectively (bilateral treatment group). A mean improvement of -0.33 (0.051) LogMAR and -0.26 (0.051) LogMAR was observed in first-affected lenadogene nolparvovec-treated eyes and second-affected/not-yet-affected placebo-treated eyes, respectively (unilateral treatment group). The proportion of patients with one or both eyes on-chart at 1.5 years was 85.4% and 72.0% for bilaterally and unilaterally treated patients, respectively. The gene therapy was well tolerated, with no systemic issues. Intraocular inflammation, which was mostly mild and well controlled with topical corticosteroids, occurred in 70.7% of lenadogene nolparvovec-treated eyes versus 10.2% of placebo-treated eyes. Among eyes treated with lenadogene nolparvovec, there was no difference in the incidence of intraocular inflammation between bilaterally and unilaterally treated patients. Overall, the REFLECT trial demonstrated an improvement of BCVA in LHON eyes carrying the m.11778G>A mtDNA mutation treated with lenadogene nolparvovec or placebo to a degree not reported in natural history studies and supports an improved benefit/risk profile for bilateral injections of lenadogene nolparvovec relative to unilateral injections.

Published
2023

49. Tensor-to-scalar ratio forecasts for extended LiteBIRD frequency configurations

Author

Fuskeland, U., Aumont, J., Aurlien, R., Baccigalupi, C., Banday, A. J., Eriksen, H. K., Errard, J., Génova-Santos, R. T., Hasebe, T., Hubmayr, J., Imada, H., Krachmalnicoff, N., Lamagna, L., Pisano, G., Poletti, D., Remazeilles, M., Thompson, K. L., Vacher, L., Wehus, I. K., Azzoni, S., Ballardini, M., Barreiro, R. B., Bartolo, N., Basyrov, A., Beck, D., Bersanelli, M., Bortolami, M., Brilenkov, M., Calabrese, E., Carones, A., Casas, F. J., Cheung, K., Chluba, J., Clark, S. E., Clermont, L., Columbro, F., Coppolecchia, A., D'Alessandro, G., de Bernardis, P., de Haan, T., de la Hoz, E., De Petris, M., Della Torre, S., Diego-Palazuelos, P., Finelli, F., Franceschet, C., Galloni, G., Galloway, M., Gerbino, M., Gervasi, M., Ghigna, T., Giardiello, S., Gjerløw, E., Gruppuso, A., Hargrave, P., Hattori, M., Hazumi, M., Hergt, L. T., Herman, D., Herranz, D., Hivon, E., Hoang, T. D., Kohri, K., Lattanzi, M., Lee, A. T., Leloup, C., Levrier, F., Lonappan, A. I., Luzzi, G., Maffei, B., Martínez-González, E., Masi, S., Matarrese, S., Matsumura, T., Migliaccio, M., Montier, L., Morgante, G., Mot, B., Mousset, L., Nagata, R., Namikawa, T., Nati, F., Natoli, P., Nerval, S., Novelli, A., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Patanchon, G., Pelgrims, V., Piacentini, F., Piccirilli, G., Polenta, G., Puglisi, G., Raffuzzi, N., Ritacco, A., Rubino-Martin, J. A., Savini, G., Scott, D., Sekimoto, Y., Shiraishi, M., Signorelli, G., Stever, S. L., Stutzer, N., Sullivan, R. M., Takakura, H., Terenzi, L., Thommesen, H., Tristram, M., Tsuji, M., Vielva, P., Weller, J., Westbrook, B., Weymann-Despres, G., Wollack, E. J., and Zannoni, M.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

LiteBIRD is a planned JAXA-led CMB B-mode satellite experiment aiming for launch in the late 2020s, with a primary goal of detecting the imprint of primordial inflationary gravitational waves. Its current baseline focal-plane configuration includes 15 frequency bands between 40 and 402 GHz, fulfilling the mission requirements to detect the amplitude of gravitational waves with the total uncertainty on the tensor-to-scalar ratio, $\delta r$, down to $\delta r<0.001$. A key aspect of this performance is accurate astrophysical component separation, and the ability to remove polarized thermal dust emission is particularly important. In this paper we note that the CMB frequency spectrum falls off nearly exponentially above 300 GHz relative to the thermal dust SED, and a relatively minor high frequency extension can therefore result in even lower uncertainties and better model reconstructions. Specifically, we compare the baseline design with five extended configurations, while varying the underlying dust modeling, in each of which the HFT (High-Frequency Telescope) frequency range is shifted logarithmically towards higher frequencies, with an upper cutoff ranging between 400 and 600 GHz. In each case, we measure the tensor-to-scalar ratio $r$ uncertainty and bias using both parametric and minimum-variance component-separation algorithms. When the thermal dust sky model includes a spatially varying spectral index and temperature, we find that the statistical uncertainty on $r$ after foreground cleaning may be reduced by as much as 30--50 % by extending the upper limit of the frequency range from 400 to 600 GHz, with most of the improvement already gained at 500 GHz. We also note that a broader frequency range leads to better ability to discriminate between models through higher $\chi^2$ sensitivity. (abridged), Comment: 18 pages, 13 figures. Published in A&A

Published
2023
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50. Transition from pediatric to adult health services: A survey of challenges, needs, and preferences of youths and parents

Author

Eric Racine, François Ouimet, Rocio Gissel Gutierrez Rojas, Marie-José Clermont, and Anne Fournier

Subjects
Transition, Pediatrics, Ethics, Human flourishing, Health systems, Autonomy, Medicine
Abstract

Aim: Transition from pediatric to adult healthcare is a critical period. Recommendations have pointed to greater preparation of youths and families and better coordination. Considerations such as patient values and preferences may – if not taken into consideration – impede uptake of clinical recommendations. This survey-based study aimed to better understand challenges, needs, and intervention preferences of youths and parents during transition. Methods: Two online surveys were designed to investigate challenges, needs, and intervention preferences of youths with a chronic or rare condition and parents during transition. The youth survey included the French translation of the Transition Readiness Assessment Questionnaire (TRAQ). Additional questions were derived from an interview-based study and aimed to grasp issues related to human flourishing in addition to more conventional clinical issues related to the transition process. Descriptive statistics were used and ANOVAs to detect differences between the groups when applicable. Results: 86 youths and 94 parents completed the survey. Average scores for TRAQ subscales were high except for “Tracking health issues” and “Appointment keeping”. Youths and parents reported being able to give their opinion. Parents were judged to be slightly over-involved. Ongoing involvement of parents in health management was desired. Awareness of differences between pediatric and adult healthcare was high, but a source of notable concern (e.g., accessibility of different medical and professional services). Information on transition was lacking. Installing a pivot-person, visits to the adult hospital, meeting other youths, and accessing transition videos were supported interventions. Conclusion: Transition readiness can be high, but significant challenges can still be present and salient. Youths and adults want to be involved and informed to prepare actively for transition through meetings or adapted materials.

Published
2025
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