189 results on '"Clendenen, Tess V"'
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2. Neighborhood walkability and sex steroid hormone levels in women
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India-Aldana, Sandra, Rundle, Andrew G., Clendenen, Tess V., Quinn, James W., Arslan, Alan A., Afanasyeva, Yelena, Koenig, Karen L., Liu, Mengling, Neckerman, Kathryn M., Thorpe, Lorna E., Zeleniuch-Jacquotte, Anne, and Chen, Yu
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- 2022
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3. International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts
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Epi Kanker, JC onderzoeksprogramma Cancer, Cancer, Timmins, Iain R, Jones, Michael E, O'Brien, Katie M, Adami, Hans-Olov, Aune, Dagfinn, Baglietto, Laura, Bertrand, Kimberly A, Brantley, Kristen D, Chen, Yu, Clague DeHart, Jessica, Clendenen, Tess V, Dossus, Laure, Eliassen, A Heather, Fletcher, Olivia, Fournier, Agnès, Håkansson, Niclas, Hankinson, Susan E, Houlston, Richard S, Joshu, Corinne E, Kirsh, Victoria A, Kitahara, Cari M, Koh, Woon-Puay, Linet, Martha S, Park, Hannah Lui, Lynch, Brigid M, May, Anne M, Mellemkjær, Lene, Milne, Roger L, Palmer, Julie R, Ricceri, Fulvio, Rohan, Thomas E, Ruddy, Kathryn J, Sánchez, Maria-Jose, Shu, Xiao-Ou, Smith-Byrne, Karl, Steindorf, Karen, Sund, Malin, Vachon, Celine M, Vatten, Lars J, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C, Wolk, Alicja, Yuan, Jian-Min, Zheng, Wei, Nichols, Hazel B, Sandler, Dale P, Swerdlow, Anthony J, Schoemaker, Minouk J, Epi Kanker, JC onderzoeksprogramma Cancer, Cancer, Timmins, Iain R, Jones, Michael E, O'Brien, Katie M, Adami, Hans-Olov, Aune, Dagfinn, Baglietto, Laura, Bertrand, Kimberly A, Brantley, Kristen D, Chen, Yu, Clague DeHart, Jessica, Clendenen, Tess V, Dossus, Laure, Eliassen, A Heather, Fletcher, Olivia, Fournier, Agnès, Håkansson, Niclas, Hankinson, Susan E, Houlston, Richard S, Joshu, Corinne E, Kirsh, Victoria A, Kitahara, Cari M, Koh, Woon-Puay, Linet, Martha S, Park, Hannah Lui, Lynch, Brigid M, May, Anne M, Mellemkjær, Lene, Milne, Roger L, Palmer, Julie R, Ricceri, Fulvio, Rohan, Thomas E, Ruddy, Kathryn J, Sánchez, Maria-Jose, Shu, Xiao-Ou, Smith-Byrne, Karl, Steindorf, Karen, Sund, Malin, Vachon, Celine M, Vatten, Lars J, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C, Wolk, Alicja, Yuan, Jian-Min, Zheng, Wei, Nichols, Hazel B, Sandler, Dale P, Swerdlow, Anthony J, and Schoemaker, Minouk J
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- 2024
4. Hypertension and risk of endometrial cancer: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium (E2C2)
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Habeshian, Talar S., primary, Peeri, Noah C., additional, De Vivo, Immaculata, additional, Schouten, Leo J., additional, Shu, Xiao-Ou, additional, Cote, Michele L., additional, Bertrand, Kimberly A., additional, Chen, Yu, additional, Clarke, Megan A., additional, Clendenen, Tess V., additional, Cook, Linda S., additional, Costas, Laura, additional, Dal Maso, Luigino, additional, Freudenheim, Jo L., additional, Friedenreich, Christine M., additional, Gallagher, Grace, additional, Gierach, Gretchen L., additional, Goodman, Marc T., additional, Jordan, Susan J., additional, La Vecchia, Carlo, additional, Lacey, James V., additional, Levi, Fabio, additional, Liao, Linda M., additional, Lipworth, Loren, additional, Lu, Lingeng, additional, Matías-Guiu, Xavier, additional, Moysich, Kirsten B., additional, Mutter, George L., additional, Na, Renhua, additional, Naduparambil, Jeffin, additional, Negri, Eva, additional, O'Connell, Kelli, additional, O'Mara, Tracy A., additional, Onieva Hernández, Irene, additional, Palmer, Julie R., additional, Parazzini, Fabio, additional, Patel, Alpa V., additional, Penney, Kathryn L., additional, Prizment, Anna E., additional, Ricceri, Fulvio, additional, Risch, Harvey A., additional, Sacerdote, Carlotta, additional, Sandin, Sven, additional, Stolzenberg-Solomon, Rachael Z., additional, van den Brandt, Piet A., additional, Webb, Penelope M., additional, Wentzensen, Nicolas, additional, Wijayabahu, Akemi T., additional, Wilkens, Lynne R., additional, Xu, Wanghong, additional, Yu, Herbert, additional, Zeleniuch-Jacquotte, Anne, additional, Zheng, Wei, additional, Du, Mengmeng, additional, and Setiawan, Veronica Wendy., additional
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- 2024
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5. Circulating unmetabolized folic acid and 5-methyltetrahydrofolate and risk of breast cancer: a nested case-control study
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Koenig, Karen L., Scarmo, Stephanie, Afanasyeva, Yelena, Clendenen, Tess V., Ueland, Per Magne, and Zeleniuch-Jacquotte, Anne
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Oncology, Experimental -- Health aspects ,Folic acid -- Health aspects ,Mass spectrometry -- Health aspects ,Liquid chromatography -- Health aspects ,Breast cancer -- Risk factors ,Cancer -- Research ,Food/cooking/nutrition ,Health - Abstract
Background/Objectives Folates found in natural foods are thought to protect against cancer. However, folic acid (FA), a synthetic form of folate used in supplements and fortified foods, may increase breast cancer risk if present in unmetabolized form (UMFA) in the circulation. This study examined the associations of serum UMFA and 5-methyltetrahydrofolate (5-mTHF), the predominant form of circulating folate, with breast cancer risk. Subjects/Methods We conducted a nested case-control study in a prospective cohort. In total, 553 cases of invasive breast cancer, diagnosed before mandatory FA fortification of grain in the US in 1998, were individually-matched to 1059 controls. Serum UMFA and 5-mTHF were measured using liquid chromatography-tandem mass spectrometry in stored serum samples, and 5-mTHF was corrected for storage degradation. Results Serum UMFA was not associated with breast cancer risk: the percentage of women with detectable levels of UMFA was similar in cases and controls (18% and 20%, respectively; p = 0.46). Two tag-SNPs in the promoter region of the FA-metabolizing gene were also not associated with risk. There was a marginally significant inverse association of 5-mTHF.sub.corrected with breast cancer risk (odds ratio for the highest vs. lowest quintile = 0.69, 95% CI = 0.49 to 0.97; p.sub.trend = 0.08). Conclusions Circulating UMFA was not associated with breast cancer risk. These results apply to countries without mandatory FA food fortification. Studies are needed in countries with mandatory fortification, where levels of UMFA are much higher than in our study., Author(s): Karen L. Koenig [sup.1], Stephanie Scarmo [sup.1], Yelena Afanasyeva [sup.1], Tess V. Clendenen [sup.1], Per Magne Ueland [sup.2], Anne Zeleniuch-Jacquotte [sup.1] [sup.3] Author Affiliations: (1) Departments of Population Health [...]
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- 2020
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6. International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts
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Timmins, Iain R., primary, Jones, Michael E., additional, O'Brien, Katie M., additional, Adami, Hans-Olov, additional, Aune, Dagfinn, additional, Baglietto, Laura, additional, Bertrand, Kimberly A., additional, Brantley, Kristen D., additional, Chen, Yu, additional, Clague DeHart, Jessica, additional, Clendenen, Tess V., additional, Dossus, Laure, additional, Eliassen, A. Heather, additional, Fletcher, Olivia, additional, Fournier, Agnès, additional, Håkansson, Niclas, additional, Hankinson, Susan E., additional, Houlston, Richard S., additional, Joshu, Corinne E., additional, Kirsh, Victoria A., additional, Kitahara, Cari M., additional, Koh, Woon-Puay, additional, Linet, Martha S., additional, Park, Hannah Lui, additional, Lynch, Brigid M., additional, May, Anne M., additional, Mellemkjær, Lene, additional, Milne, Roger L., additional, Palmer, Julie R., additional, Ricceri, Fulvio, additional, Rohan, Thomas E., additional, Ruddy, Kathryn J., additional, Sánchez, Maria-Jose, additional, Shu, Xiao-Ou, additional, Smith-Byrne, Karl, additional, Steindorf, Karen, additional, Sund, Malin, additional, Vachon, Celine M., additional, Vatten, Lars J., additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Willett, Walter C., additional, Wolk, Alicja, additional, Yuan, Jian-Min, additional, Zheng, Wei, additional, Nichols, Hazel B., additional, Sandler, Dale P., additional, Swerdlow, Anthony J., additional, and Schoemaker, Minouk J., additional
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- 2023
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7. Long-Term Exposure to Walkable Residential Neighborhoods and Risk of Obesity-Related Cancer in the New York University Women’s Health Study (NYUWHS)
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India-Aldana, Sandra, primary, Rundle, Andrew G., additional, Quinn, James W., additional, Clendenen, Tess V., additional, Afanasyeva, Yelena, additional, Koenig, Karen L., additional, Liu, Mengling, additional, Neckerman, Kathryn M., additional, Thorpe, Lorna E., additional, Zeleniuch-Jacquotte, Anne, additional, and Chen, Yu, additional
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- 2023
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8. International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts.
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Timmins, Iain R., Jones, Michael E., O'Brien, Katie M., Adami, Hans-Olov, Aune, Dagfinn, Baglietto, Laura, Bertrand, Kimberly A., Brantley, Kristen D., Chen, Yu, Clague DeHart, Jessica, Clendenen, Tess V., Dossus, Laure, Eliassen, A. Heather, Fletcher, Olivia, Fournier, Agnès, Håkansson, Niclas, Hankinson, Susan E., Houlston, Richard S., Joshu, Corinne E., and Kirsh, Victoria A.
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- 2024
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9. Mid‐life adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and late‐life subjective cognitive complaints in women.
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Song, Yixiao, Wu, Fen, Sharma, Sneha, Clendenen, Tess V., India‐Aldana, Sandra, Afanasyeva, Yelena, Gu, Yian, Koenig, Karen L., Zeleniuch‐Jacquotte, Anne, and Chen, Yu
- Abstract
INTRODUCTION: Evidence is limited on the role of mid‐life Dietary Approaches to Stop Hypertension (DASH) diet in late‐life subjective cognitive complaints (SCCs). METHODS: We included 5116 women (mean age in 1985–1991: 46 years) from the New York University Women's Health Study. SCCs were assessed from 2018 to 2020 (mean age: 79 years) by a 6‐item questionnaire. RESULTS: Compared to women in the bottom quartile of the DASH scores, the odds ratio (OR) for having two or more SCCs was 0.83 (95% confidence interval: 0.70–0.99) for women in the top quartile of DASH scores at baseline (P for trend = 0.019). The association was similar with multiple imputation and inverse probability weighting to account for potential selection bias. The inverse association was stronger in women without a history of cancer (P for interaction = 0.003). DISCUSSION: Greater adherence to the DASH diet in mid‐life was associated with lower prevalence of late‐life SCCs in women. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Association of hormonal and reproductive factors with differentiated thyroid cancer risk in women: a pooled prospective cohort analysis.
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O'Grady, Thomas J, Rinaldi, Sabina, Michels, Kara A, Adami, Hans-Olov, Buring, Julie E, Chen, Yu, Clendenen, Tess V, D'Aloisio, Aimee, DeHart, Jessica Clague, Franceschi, Silvia, Freedman, Neal D, Gierach, Gretchen L, Giles, Graham G, Lacey, James V, Lee, I-Min, Liao, Linda M, Linet, Martha S, McCullough, Marjorie L, Patel, Alpa V, and Prizment, Anna
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MENARCHE ,ORAL contraceptives ,CONTRACEPTION ,THYROID cancer ,DISEASE risk factors ,SEX hormones ,COHORT analysis ,PROPORTIONAL hazards models - Abstract
Background The incidence of differentiated thyroid cancer (DTC) is higher in women than in men but whether sex steroid hormones contribute to this difference remains unclear. Studies of reproductive and hormonal factors and thyroid cancer risk have provided inconsistent results. Methods Original data from 1 252 907 women in 16 cohorts in North America, Europe, Australia and Asia were combined to evaluate associations of DTC risk with reproductive and hormonal factors. Multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% CIs. Results During follow-up, 2142 women were diagnosed with DTC. Factors associated with higher risk of DTC included younger age at menarche (<10 vs 10–11 years; HR, 1.28; 95% CI, 1.00–1.64), younger (<40; HR, 1.31; 95% CI, 1.05–1.62) and older (≥55; HR, 1.33; 95% CI, 1.05–1.68) ages at menopause (vs 40–44 years), ever use of menopausal hormone therapy (HR, 1.16; 95% CI, 1.02–1.33) and previous hysterectomy (HR, 1.25; 95% CI, 1.13–1.39) or bilateral oophorectomy (HR, 1.14; 95% CI, 1.00–1.29). Factors associated with lower risk included longer-term use (≥5 vs <5 years) of oral contraceptives (HR, 0.86; 95% CI, 0.76–0.96) among those who ever used oral contraception and baseline post-menopausal status (HR, 0.82; 95% CI, 0.70–0.96). No associations were observed for parity, duration of menopausal hormone therapy use or lifetime number of reproductive years or ovulatory cycles. Conclusions Our study provides some evidence linking reproductive and hormonal factors with risk of DTC. Results should be interpreted cautiously considering the modest strength of the associations and potential for exposure misclassification and detection bias. Prospective studies of pre-diagnostic circulating sex steroid hormone measurements and DTC risk may provide additional insight. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Breast cancer risk prediction in women aged 35–50 years: impact of including sex hormone concentrations in the Gail model
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Clendenen, Tess V., Ge, Wenzhen, Koenig, Karen L., Afanasyeva, Yelena, Agnoli, Claudia, Brinton, Louise A., Darvishian, Farbod, Dorgan, Joanne F., Eliassen, A. Heather, Falk, Roni T., Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith, Key, Timothy J., Krogh, Vittorio, Nichols, Hazel B., Sandler, Dale P., Schoemaker, Minouk J., Sluss, Patrick M., Sund, Malin, Swerdlow, Anthony J., Visvanathan, Kala, Zeleniuch-Jacquotte, Anne, and Liu, Mengling
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- 2019
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12. Intake of vitamins A, C, and E and folate and the risk of ovarian cancer in a pooled analysis of 10 cohort studies
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Koushik, Anita, Wang, Molin, Anderson, Kristin E., van den Brandt, Piet, Clendenen, Tess V., Eliassen, A. Heather, Freudenheim, Jo L., Genkinger, Jeanine M., Håkansson, Niclas, Marshall, James R., McCullough, Marjorie L., Miller, Anthony B., Robien, Kim, Rohan, Thomas E., Schairer, Catherine, Schouten, Leo J., Tworoger, Shelley S., Wang, Ying, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Smith-Warner, Stephanie A.
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- 2015
13. Premenopausal Circulating Androgens and Risk of Endometrial Cancer: results of a Prospective Study
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Clendenen, Tess V., Hertzmark, Kathryn, Koenig, Karen L., Lundin, Eva, Rinaldi, Sabina, Johnson, Theron, Krogh, Vittorio, Hallmans, Göran, Idahl, Annika, Lukanova, Annekatrin, and Zeleniuch-Jacquotte, Anne
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- 2016
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14. Partially linear single index Cox regression model in nested case-control studies
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Shang, Shulian, Liu, Mengling, Zeleniuch-Jacquotte, Anne, Clendenen, Tess V., Krogh, Vittorio, Hallmans, Goran, and Lu, Wenbin
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- 2013
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15. Circulating prolactin levels and risk of epithelial ovarian cancer
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Clendenen, Tess V., Arslan, Alan A., Lokshin, Anna E., Liu, Mengling, Lundin, Eva, Koenig, Karen L., Berrino, Franco, Hallmans, Goran, Idahl, Annika, Krogh, Vittorio, Lukanova, Annekatrin, Marrangoni, Adele, Muti, Paola, Nolen, Brian M., Ohlson, Nina, Shore, Roy E., Sieri, Sabina, and Zeleniuch-Jacquotte, Anne
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- 2013
16. Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer
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Lundin, Eva, Wirgin, Isaac, Lukanova, Annekatrin, Afanasyeva, Yelena, Krogh, Vittorio, Axelsson, Tomas, Hemminki, Kari, Clendenen, Tess V., Arslan, Alan A., Ohlson, Nina, Sieri, Sabina, Roy, Nirmal, Koenig, Karen L., Idahl, Annika, Berrino, Franco, Toniolo, Paolo, Hallmans, Göran, Försti, Asta, Muti, Paola, Lenner, Per, Shore, Roy E., and Zeleniuch-Jacquotte, Anne
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- 2012
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17. Gut Microbiota and Subjective Memory Complaints in Older Women
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Wu, Fen, primary, Davey, Samuel, additional, Clendenen, Tess V., additional, Koenig, Karen L., additional, Afanasyeva, Yelena, additional, Zhou, Boyan, additional, Bedi, Sukhleen, additional, Li, Huilin, additional, Zeleniuch-Jacquotte, Anne, additional, and Chen, Yu, additional
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- 2022
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18. Factors associated with inflammation markers, a cross-sectional analysis
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Clendenen, Tess V., Koenig, Karen L., Arslan, Alan A., Lukanova, Annekatrin, Berrino, Franco, Gu, Yian, Hallmans, Goran, Idahl, Annika, Krogh, Vittorio, Lokshin, Anna E., Lundin, Eva, Muti, Paola, Marrangoni, Adele, Nolen, Brian M., Ohlson, Nina, Shore, Roy E., Sieri, Sabina, and Zeleniuch-Jacquotte, Anne
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- 2011
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19. Neighborhood Walkability and Sex Steroid Hormone Levels in Women
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India Aldana, Sandra, primary, Rundle, Andrew G., additional, Clendenen, Tess V., additional, Quinn, James W., additional, Arslan, Alan A., additional, Afanasyeva, Yelena, additional, Koenig, Karen L., additional, Liu, Mengling, additional, Neckerman, Kathryn M., additional, Thorpe, Lorna E., additional, Zeleniuch-Jacquotte, Anne, additional, and Chen, Yu, additional
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- 2022
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20. Neighborhood Walkability and Mortality in a Prospective Cohort of Women
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India Aldana, Sandra, primary, Rundle, Andrew G., additional, Zeleniuch Jacquotte, Anne, additional, Quinn, James W., additional, Kim, Byoungjun, additional, Afanasyeva, Yelena, additional, Clendenen, Tess V., additional, Koenig, Karen L., additional, Liu, Mengling, additional, Neckerman, Kathryn M., additional, Thorpe, Lorna E., additional, and Chen, Yu, additional
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- 2021
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21. Neighborhood Walkability and Sex Hormone Levels in Women
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India Aldana, Sandra, primary, Rundle, Andrew G., additional, Clendenen, Tess V., additional, Quinn, James W., additional, Arslan, Alan A., additional, Afanasyeva, Yelena, additional, Koenig, Karen L., additional, Liu, Mengling, additional, Thorpe, Lorna E., additional, Zeleniuch Jacquotte, Anne, additional, and Chen, Yu, additional
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- 2021
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22. Neighborhood Walkability and Mortality in a Prospective Cohort of Women
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India-Aldana, Sandra, primary, Rundle, Andrew G., additional, Zeleniuch-Jacquotte, Anne, additional, Quinn, James W., additional, Kim, Byoungjun, additional, Afanasyeva, Yelena, additional, Clendenen, Tess V., additional, Koenig, Karen L., additional, Liu, Mengling, additional, Neckerman, Kathryn M., additional, Thorpe, Lorna E., additional, and Chen, Yu, additional
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- 2021
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23. Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women
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Clendenen, Tess V., Ge, Wenzhen, Koenig, Karen L., Afanasyeva, Yelena, Agnoli, Claudia, Bertone-Johnson, Elizabeth, Brinton, Louise A., Darvishian, Farbod, Dorgan, Joanne F., Eliassen, A. Heather, Falk, Roni T., Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith, Key, Timothy J., Krogh, Vittorio, Nichols, Hazel B., Sandler, Dale P., Schoemaker, Minouk J., Sluss, Patrick M., Sund, Malin, Swerdlow, Anthony J., Visvanathan, Kala, Liu, Mengling, Zeleniuch-Jacquotte, Anne, Clendenen, Tess V., Ge, Wenzhen, Koenig, Karen L., Afanasyeva, Yelena, Agnoli, Claudia, Bertone-Johnson, Elizabeth, Brinton, Louise A., Darvishian, Farbod, Dorgan, Joanne F., Eliassen, A. Heather, Falk, Roni T., Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith, Key, Timothy J., Krogh, Vittorio, Nichols, Hazel B., Sandler, Dale P., Schoemaker, Minouk J., Sluss, Patrick M., Sund, Malin, Swerdlow, Anthony J., Visvanathan, Kala, Liu, Mengling, and Zeleniuch-Jacquotte, Anne
- Abstract
Context: We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies. Objective: This study assessed whether risk factors for breast cancer are correlates of AMH concentration. Methods: This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population. Results: Adjusting for age and cohort, AMH positively associated with age at menarche (P < 0.0001) and parity (P = 0.0008) and inversely associated with hysterectomy/partial oophorectomy (P = 0.0008). Compared with women of normal weight, AMH was lower (relative geometric mean difference 27%, P < 0.0001) among women who were obese. Current oral contraceptive (OC) use and current/former smoking were associated with lower AMH concentration than never use (40% and 12% lower, respectively, P < 0.0001). We observed higher AMH concentrations among women who had had a benign breast biopsy (15% higher, P = 0.03), a surrogate for benign breast disease, an association that has not been reported. In analyses stratified by age (<40 vs ≥40), associations of AMH with body mass index and OCs were similar in younger and older women, while associations with the other factors (menarche, parity, hysterectomy/partial oophorectomy, smoking, and benign breast biopsy) were limited to women ≥40 (P-interaction < 0.05). Conclusion: This is the largest study of AMH and breast cancer risk factors among women from the general population (not presenting with infertility), and it suggests that most associations are limited to women over 40, who are approaching menopause and whose AMH concentration is declining.
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- 2021
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24. Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer
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Clendenen, Tess V., Arslan, Alan A., Koenig, Karen L., Enquist, Kerstin, Wirgin, Isaac, Ågren, Åsa, Lukanova, Annekatrin, Sjodin, Hubert, Zeleniuch-Jacquotte, Anne, Shore, Roy E., Hallmans, Göran, Toniolo, Paolo, and Lundin, Eva
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- 2008
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25. Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women
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Clendenen, Tess V, primary, Ge, Wenzhen, additional, Koenig, Karen L, additional, Afanasyeva, Yelena, additional, Agnoli, Claudia, additional, Bertone-Johnson, Elizabeth, additional, Brinton, Louise A, additional, Darvishian, Farbod, additional, Dorgan, Joanne F, additional, Eliassen, A Heather, additional, Falk, Roni T, additional, Hallmans, Göran, additional, Hankinson, Susan E, additional, Hoffman-Bolton, Judith, additional, Key, Timothy J, additional, Krogh, Vittorio, additional, Nichols, Hazel B, additional, Sandler, Dale P, additional, Schoemaker, Minouk J, additional, Sluss, Patrick M, additional, Sund, Malin, additional, Swerdlow, Anthony J, additional, Visvanathan, Kala, additional, Liu, Mengling, additional, and Zeleniuch-Jacquotte, Anne, additional
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- 2021
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26. Reproductive and Hormonal Factors and Risk of Ovarian Cancer by Tumor Dominance : Results from the Ovarian Cancer Cohort Consortium (OC3)
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Huang, Tianyi, Townsend, Mary K., Wentzensen, Nicolas, Trabert, Britton, White, Emily, Arslan, Alan A., Weiderpass, Elisabete, Buring, Julie E., Clendenen, Tess V., Giles, Graham G., Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Sandler, Dale P., Schouten, Leo J., van den Brandt, Piet A., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Huang, Tianyi, Townsend, Mary K., Wentzensen, Nicolas, Trabert, Britton, White, Emily, Arslan, Alan A., Weiderpass, Elisabete, Buring, Julie E., Clendenen, Tess V., Giles, Graham G., Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Sandler, Dale P., Schouten, Leo J., van den Brandt, Piet A., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
- Abstract
Background: Laterality of epithelial ovarian tumors may reflect the underlying carcinogenic pathways and origins of tumor cells. Methods: We pooled data from 9 prospective studies participating in the Ovarian Cancer Cohort Consortium. Information on measures of tumor size or tumor dominance was extracted from surgical pathology reports or obtained through cancer registries. We defined dominant tumors as those restricted to one ovary or where the dimension of one ovary was at least twice as large as the other, and nondominant tumors as those with similar dimensions across the two ovaries or peritoneal tumors. Competing risks Cox models were used to examine whether associations with reproductive and hormonal risk factors differed by ovarian tumor dominance. Results: Of 1,058 ovarian cancer cases with tumor dominance information, 401 were left-dominant, 363 were right-dominant, and 294 were nondominant. Parity was more strongly inversely associated with risk of dominant than nondominant ovarian cancer (P-heterogeneity = 0.004). Ever use of oral contraceptives (OC) was associated with lower risk of dominant tumors, but was not associated with nondominant tumors (Pheterogeneity = 0.01). Higher body mass index was associated with higher risk of left-dominant tumors, but not significantly associated with risk of right-dominant or nondominant tumors (P-heterogeneity = 0.08). Conclusions: These data suggest that reproductive and hormonal risk factors appear to have a stronger impact on dominant tumors, which may have an ovarian or endometriosis origin. Impact: Examining the associations of ovarian cancer risk factors by tumor dominance may help elucidate the mechanisms through which these factors influence ovarian cancer risk.
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- 2020
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27. Reproductive and hormonal factors and risk of ovarian cancer by tumor dominance: Results from the ovarian cancer Cohort Consortium (OC3)
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Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Huang, Tianyi, Townsend, Mary K., Wentzensen, Nicolas, Trabert, Britton, White, Emily, Arslan, Alan A., Weiderpass, Elisabete, Buring, Julie E., Clendenen, Tess V., Giles, Graham G., Lee, I. Min, Milne, Roger L., Charlotte Onland-Moret, N., Peters, Ulrike, Sandler, Dale P., Schouten, Leo J., van den Brandt, Piet A., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Huang, Tianyi, Townsend, Mary K., Wentzensen, Nicolas, Trabert, Britton, White, Emily, Arslan, Alan A., Weiderpass, Elisabete, Buring, Julie E., Clendenen, Tess V., Giles, Graham G., Lee, I. Min, Milne, Roger L., Charlotte Onland-Moret, N., Peters, Ulrike, Sandler, Dale P., Schouten, Leo J., van den Brandt, Piet A., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
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- 2020
28. Estimation and selection of complex covariate effects in pooled nested case–control studies with heterogeneity
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Liu, Mengling, Lu, Wenbin, Krogh, Vittorio, Hallmans, Göran, Clendenen, Tess V., and Zeleniuch-Jacquotte, Anne
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- 2013
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29. Comparison of 3-point dixon imaging and fuzzy C-means clustering methods for breast density measurement
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Clendenen, Tess V., Zeleniuch-Jacquotte, Anne, Moy, Linda, Pike, Malcolm C., Rusinek, Henry, and Kim, Sungheon
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- 2013
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30. Reproductive and Hormonal Factors and Risk of Ovarian Cancer by Tumor Dominance: Results from the Ovarian Cancer Cohort Consortium (OC3)
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Huang, Tianyi, primary, Townsend, Mary K., additional, Wentzensen, Nicolas, additional, Trabert, Britton, additional, White, Emily, additional, Arslan, Alan A., additional, Weiderpass, Elisabete, additional, Buring, Julie E., additional, Clendenen, Tess V., additional, Giles, Graham G., additional, Lee, I-Min, additional, Milne, Roger L., additional, Onland-Moret, N. Charlotte, additional, Peters, Ulrike, additional, Sandler, Dale P., additional, Schouten, Leo J., additional, van den Brandt, Piet A., additional, Wolk, Alicja, additional, Zeleniuch-Jacquotte, Anne, additional, and Tworoger, Shelley S., additional
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- 2020
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31. Ovarian cancer risk factors by tumor aggressiveness : An analysis from the Ovarian Cancer Cohort Consortium
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Fortner, Renée T., Poole, Elizabeth M., Wentzensen, Nicolas A., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Clendenen, Tess V., Fournier, Agnès, Fraser, Gary, Gapstur, Susan M., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sánchez, Maria-José, Schairer, Catherine, Schouten, Leo J., Tjonneland, Anne, Townsend, Mary K., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Fortner, Renée T., Poole, Elizabeth M., Wentzensen, Nicolas A., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Clendenen, Tess V., Fournier, Agnès, Fraser, Gary, Gapstur, Susan M., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sánchez, Maria-José, Schairer, Catherine, Schouten, Leo J., Tjonneland, Anne, Townsend, Mary K., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
- Abstract
Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in <1 year, n = 864), very aggressive (death in 1 to < 3 years, n = 1,390), moderately aggressive (death in 3 to < 5 years, n = 639), and less aggressive (lived 5+ years, n = 1,691). Using competing risks Cox proportional hazards regression, we assessed heterogeneity of associations by tumor aggressiveness for all cases and among serous and endometrioid/clear cell tumors. Associations between parity (phet = 0.01), family history of ovarian cancer (phet = 0.02), body mass index (BMI; phet ≤ 0.04) and smoking (phet < 0.01) and ovarian cancer risk differed by aggressiveness. A first/single pregnancy, relative to nulliparity, was inversely associated with highly aggressive disease (HR: 0.72; 95% CI [0.58-0.88]), no association was observed for subsequent pregnancies (per pregnancy, 0.97 [0.92-1.02]). In contrast, first and subsequent pregnancies were similarly associated with less aggressive disease (0.87 for both). Family history of ovarian cancer was only associated with risk of less aggressive disease (1.94 [1.47-2.55]). High BMI (≥35 vs. 20 to < 25 kg/m2 , 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.
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- 2019
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32. Reply to: Anti-Mullerian hormone and breast cancer risk- is the correlation possibly associated with the PCOS?
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Clendenen, Tess V, Dorgan, Joanne, and Zeleniuch-Jacquotte, Anne
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Adult ,Anti-Mullerian Hormone ,Risk Factors ,Humans ,Breast Neoplasms ,Female ,Risk Assessment ,Article ,Polycystic Ovary Syndrome - Published
- 2018
33. Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium
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Fortner, Renée T., primary, Poole, Elizabeth M., additional, Wentzensen, Nicolas A., additional, Trabert, Britton, additional, White, Emily, additional, Arslan, Alan A., additional, Patel, Alpa V., additional, Setiawan, V. Wendy, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Adami, Hans‐Olov, additional, Black, Amanda, additional, Bernstein, Leslie, additional, Brinton, Louise A., additional, Buring, Julie, additional, Clendenen, Tess V., additional, Fournier, Agnès, additional, Fraser, Gary, additional, Gapstur, Susan M., additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Gram, Inger T., additional, Hartge, Patricia, additional, Hoffman‐Bolton, Judith, additional, Idahl, Annika, additional, Kaaks, Rudolf, additional, Kirsh, Victoria A., additional, Knutsen, Synnove, additional, Koh, Woon‐Puay, additional, Lacey, James V., additional, Lee, I‐Min, additional, Lundin, Eva, additional, Merritt, Melissa A., additional, Milne, Roger L., additional, Onland‐Moret, N. Charlotte, additional, Peters, Ulrike, additional, Poynter, Jenny N., additional, Rinaldi, Sabina, additional, Robien, Kim, additional, Rohan, Thomas, additional, Sánchez, Maria‐José, additional, Schairer, Catherine, additional, Schouten, Leo J., additional, Tjonneland, Anne, additional, Townsend, Mary K., additional, Travis, Ruth C., additional, Trichopoulou, Antonia, additional, Brandt, Piet A., additional, Vineis, Paolo, additional, Wilkens, Lynne, additional, Wolk, Alicja, additional, Yang, Hannah P., additional, Zeleniuch‐Jacquotte, Anne, additional, and Tworoger, Shelley S., additional
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- 2019
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34. Temporal reliability of cytokines and growth factors in EDTA plasma
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Marrangoni Adele M, Koenig Karen L, Hallmans Göran, Idahl Annika, Lokshin Anna E, Arslan Alan A, Clendenen Tess V, Nolen Brian M, Ohlson Nina, Zeleniuch-Jacquotte Anne, and Lundin Eva
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Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Background Cytokines are involved in the development of chronic diseases, including cancer. It is important to evaluate the temporal reproducibility of cytokines in plasma prior to conducting epidemiologic studies utilizing these markers. Findings We assessed the temporal reliability of CRP, 22 cytokines and their soluble receptors (IL-1α, IL-1β, IL-1RA, IL-2, sIL-2R, IL-4, IL-5, IL-6, sIL-6R, IL-7, IL-8, IL-10, IL-12p40, IL-12p70, IL-13, IL-15, IL-17, TNFα, sTNF-R1, sTNF-R2, IFNα, IFNγ) and eight growth factors (GM-CSF, EGF, bFGF, G-CSF, HGF, VEGF, EGFR, ErbB2) in repeated EDTA plasma samples collected an average of two years apart from 18 healthy women (age range: 42-62) enrolled in a prospective cohort study. We also estimated the correlation between serum and plasma biomarker levels using 18 paired clinical samples from postmenopausal women (age range: 75-86). Twenty-six assays were able to detect their analytes in at least 70% of samples. Of those 26 assays, we observed moderate to high intra-class correlation coefficients (ICCs)(ranging from 0.53-0.89) for 22 assays, and low ICCs (0-0.47) for four assays. Serum and plasma levels were highly correlated (r > 0.6) for most markers, except for seven assays (r < 0.5). Conclusions For 22 of the 31 biomarkers, a single plasma measurement is a reliable estimate of a woman's average level over a two-year period.
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- 2010
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35. Circulating anti-Müllerian hormone and breast cancer risk : a study in ten prospective cohorts
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Ge, Wenzhen, Clendenen, Tess V., Afanasyeva, Yelena, Koenig, Karen L., Agnoli, Claudia, Brinton, Louise A., Dorgan, Joanne F., Eliassen, A. Heather, Falk, Roni T., Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith, Key, Timothy J., Krogh, Vittorio, Nichols, Hazel B., Sandler, Dale P., Schoemaker, Minouk J., Sluss, Patrick M., Sund, Malin, Swerdlow, Anthony J., Visvanathan, Kala, Liu, Mengling, Zeleniuch-Jacquotte, Anne, Ge, Wenzhen, Clendenen, Tess V., Afanasyeva, Yelena, Koenig, Karen L., Agnoli, Claudia, Brinton, Louise A., Dorgan, Joanne F., Eliassen, A. Heather, Falk, Roni T., Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith, Key, Timothy J., Krogh, Vittorio, Nichols, Hazel B., Sandler, Dale P., Schoemaker, Minouk J., Sluss, Patrick M., Sund, Malin, Swerdlow, Anthony J., Visvanathan, Kala, Liu, Mengling, and Zeleniuch-Jacquotte, Anne
- Abstract
A strong positive association has been observed between circulating anti‐Müllerian hormone (AMH), a biomarker of ovarian reserve, and breast cancer risk in three prospective studies. Confirming this association is important because of the paucity of biomarkers of breast cancer risk in premenopausal women. We conducted a consortium study including ten prospective cohorts that had collected blood from premenopausal women. A nested case–control design was implemented within each cohort. A total of 2,835 invasive (80%) and in situ (20%) breast cancer cases were individually matched to controls (n = 3,122) on age at blood donation. AMH was measured using a high sensitivity enzyme‐linked immunoabsorbent assay. Conditional logistic regression was applied to the aggregated dataset. There was a statistically significant trend of increasing breast cancer risk with increasing AMH concentration (ptrend across quartiles <0.0001) after adjusting for breast cancer risk factors. The odds ratio (OR) for breast cancer in the top vs. bottom quartile of AMH was 1.60 (95% CI = 1.31–1.94). Though the test for interaction was not statistically significant (pinteraction = 0.15), the trend was statistically significant only for tumors positive for both estrogen receptor (ER) and progesterone receptor (PR): ER+/PR+: ORQ4–Q1 = 1.96, 95% CI = 1.46–2.64, ptrend <0.0001; ER+/PR−: ORQ4–Q1 = 0.82, 95% CI = 0.40–1.68, ptrend = 0.51; ER−/PR+: ORQ4–Q1 = 3.23, 95% CI = 0.48–21.9, ptrend = 0.26; ER−/PR−: ORQ4–Q1 = 1.15, 95% CI = 0.63–2.09, ptrend = 0.60. The association was observed for both pre‐ (ORQ4–Q1= 1.35, 95% CI = 1.05–1.73) and post‐menopausal (ORQ4–Q1 = 1.61, 95% CI = 1.03–2.53) breast cancer (pinteraction = 0.34). In this large consortium study, we confirmed that AMH is associated with breast cancer risk, with a 60% increase in risk for women in the top vs. bottom quartile of AMH. What's new? To make informed decisions about screening and prevention, women need tools to accurately asses
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- 2018
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36. Reproductive and Hormonal Factors and Risk of Ovarian Cancer by Tumor Dominance: Results from the Ovarian Cancer Cohort Consortium (OC3).
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Tianyi Huang, Townsend, Mary K., Wentzensen, Nicolas, Trabert, Britton, White, Emily, Arslan, Alan A., Weiderpass, Elisabete, Buring, Julie E., Clendenen, Tess V., Giles, Graham G., I-Min Lee, Milne, Roger L., Onland-Moret, N. Charlotte, Peters, Ulrike, Sandler, Dale P., Schouten, Leo J., van den Brandt, Piet A., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
- Abstract
Background: Laterality of epithelial ovarian tumors may reflect the underlying carcinogenic pathways and origins of tumor cells. Methods: We pooled data from 9 prospective studies participating in the Ovarian Cancer Cohort Consortium. Information on measures of tumor size or tumor dominance was extracted from surgical pathology reports or obtained through cancer registries. We defined dominant tumors as those restricted to one ovary or where the dimension of one ovary was at least twice as large as the other, and nondominant tumors as those with similar dimensions across the two ovaries or peritoneal tumors. Competing risks Cox models were used to examine whether associations with reproductive and hormonal risk factors differed by ovarian tumor dominance. Results: Of 1,058 ovarian cancer cases with tumor dominance information, 401 were left-dominant, 363 were right-dominant, and 294 were nondominant. Parity was more strongly inversely associated with risk of dominant than nondominant ovarian cancer (P
heterogeneity = 0.004). Ever use of oral contraceptives (OC) was associated with lower risk of dominant tumors, but was not associated with nondominant tumors (Pheterogeneity = 0.01). Higher body mass index was associated with higher risk of left-dominant tumors, but not significantly associated with risk of right-dominant or nondominant tumors (Pheterogeneity = 0.08). Conclusions: These data suggest that reproductive and hormonal risk factors appear to have a stronger impact on dominant tumors, which may have an ovarian or endometriosis origin. [ABSTRACT FROM AUTHOR]- Published
- 2020
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37. Authors’ reply to: Anti-Müllerian hormone and breast cancer risk: is the correlation possibly associated with PCOS
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Clendenen, Tess V., primary, Dorgan, Joanne, additional, and Zeleniuch-Jacquotte, Anne, additional
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- 2018
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38. Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts
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McCullough, Marjorie L, primary, Zoltick, Emilie S, additional, Weinstein, Stephanie J, additional, Fedirko, Veronika, additional, Wang, Molin, additional, Cook, Nancy R, additional, Eliassen, A Heather, additional, Zeleniuch-Jacquotte, Anne, additional, Agnoli, Claudia, additional, Albanes, Demetrius, additional, Barnett, Matthew J, additional, Buring, Julie E, additional, Campbell, Peter T, additional, Clendenen, Tess V, additional, Freedman, Neal D, additional, Gapstur, Susan M, additional, Giovannucci, Edward L, additional, Goodman, Gary G, additional, Haiman, Christopher A, additional, Ho, Gloria Y F, additional, Horst, Ronald L, additional, Hou, Tao, additional, Huang, Wen-Yi, additional, Jenab, Mazda, additional, Jones, Michael E, additional, Joshu, Corinne E, additional, Krogh, Vittorio, additional, Lee, I-Min, additional, Lee, Jung Eun, additional, Männistö, Satu, additional, Le Marchand, Loic, additional, Mondul, Alison M, additional, Neuhouser, Marian L, additional, Platz, Elizabeth A, additional, Purdue, Mark P, additional, Riboli, Elio, additional, Robsahm, Trude Eid, additional, Rohan, Thomas E, additional, Sasazuki, Shizuka, additional, Schoemaker, Minouk J, additional, Sieri, Sabina, additional, Stampfer, Meir J, additional, Swerdlow, Anthony J, additional, Thomson, Cynthia A, additional, Tretli, Steinar, additional, Tsugane, Schoichiro, additional, Ursin, Giske, additional, Visvanathan, Kala, additional, White, Kami K, additional, Wu, Kana, additional, Yaun, Shiaw-Shyuan, additional, Zhang, Xuehong, additional, Willett, Walter C, additional, Gail, Mitchel H, additional, Ziegler, Regina G, additional, and Smith-Warner, Stephanie A, additional
- Published
- 2018
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39. Circulating anti‐Müllerian hormone and breast cancer risk: A study in ten prospective cohorts
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Ge, Wenzhen, primary, Clendenen, Tess V., additional, Afanasyeva, Yelena, additional, Koenig, Karen L., additional, Agnoli, Claudia, additional, Brinton, Louise A., additional, Dorgan, Joanne F., additional, Eliassen, A. Heather, additional, Falk, Roni T., additional, Hallmans, Göran, additional, Hankinson, Susan E., additional, Hoffman‐Bolton, Judith, additional, Key, Timothy J., additional, Krogh, Vittorio, additional, Nichols, Hazel B., additional, Sandler, Dale P., additional, Schoemaker, Minouk J., additional, Sluss, Patrick M., additional, Sund, Malin, additional, Swerdlow, Anthony J., additional, Visvanathan, Kala, additional, Liu, Mengling, additional, and Zeleniuch‐Jacquotte, Anne, additional
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- 2018
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40. Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts.
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McCullough, Marjorie L, Zoltick, Emilie S, Weinstein, Stephanie J, Fedirko, Veronika, Wang, Molin, Cook, Nancy R, Eliassen, A Heather, Zeleniuch-Jacquotte, Anne, Agnoli, Claudia, Albanes, Demetrius, Barnett, Matthew J, Buring, Julie E, Campbell, Peter T, Clendenen, Tess V, Freedman, Neal D, Gapstur, Susan M, Giovannucci, Edward L, Goodman, Gary G, Haiman, Christopher A, and Ho, Gloria Y F
- Abstract
Background: Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize risk are unknown. Current Institute of Medicine (IOM) vitamin D guidance is based solely on bone health.Methods: We pooled participant-level data from 17 cohorts, comprising 5706 colorectal cancer case participants and 7107 control participants with a wide range of circulating 25(OH)D concentrations. For 30.1% of participants, 25(OH)D was newly measured. Previously measured 25(OH)D was calibrated to the same assay to permit estimating risk by absolute concentrations. Study-specific relative risks (RRs) for prediagnostic season-standardized 25(OH)D concentrations were calculated using conditional logistic regression and pooled using random effects models.Results: Compared with the lower range of sufficiency for bone health (50-<62.5 nmol/L), deficient 25(OH)D (<30 nmol/L) was associated with 31% higher colorectal cancer risk (RR = 1.31, 95% confidence interval [CI] = 1.05 to 1.62); 25(OH)D above sufficiency (75-<87.5 and 87.5-<100 nmol/L) was associated with 19% (RR = 0.81, 95% CI = 0.67 to 0.99) and 27% (RR = 0.73, 95% CI = 0.59 to 0.91) lower risk, respectively. At 25(OH)D of 100 nmol/L or greater, risk did not continue to decline and was not statistically significantly reduced (RR = 0.91, 95% CI = 0.67 to 1.24, 3.5% of control participants). Associations were minimally affected when adjusting for body mass index, physical activity, or other risk factors. For each 25 nmol/L increment in circulating 25(OH)D, colorectal cancer risk was 19% lower in women (RR = 0.81, 95% CI = 0.75 to 0.87) and 7% lower in men (RR = 0.93, 95% CI = 0.86 to 1.00) (two-sided Pheterogeneity by sex = .008). Associations were inverse in all subgroups, including colorectal subsite, geographic region, and season of blood collection.Conclusions: Higher circulating 25(OH)D was related to a statistically significant, substantially lower colorectal cancer risk in women and non-statistically significant lower risk in men. Optimal 25(OH)D concentrations for colorectal cancer risk reduction, 75-100 nmol/L, appear higher than current IOM recommendations. [ABSTRACT FROM AUTHOR]- Published
- 2019
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41. Ovarian Cancer Risk Factors by Histologic Subtype : An Analysis From the Ovarian Cancer Cohort Consortium
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Wentzensen, Nicolas, Poole, Elizabeth M., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Butler, Lesley M., Chamosa, Saioa, Clendenen, Tess V., Dossus, Laure, Fortner, Renee, Gapstur, Susan M., Gaudet, Mia M., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Victoria, Koh, Woon-Puay, Lacey, James V., Jr., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Sjoholm, Louise K., Sieri, Sabina, Swerdlow, Anthony, Tjonneland, Anna, Travis, Ruth, Trichopoulou, Antonia, van den Brandt, Piet A., Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Wentzensen, Nicolas, Poole, Elizabeth M., Trabert, Britton, White, Emily, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A., Buring, Julie, Butler, Lesley M., Chamosa, Saioa, Clendenen, Tess V., Dossus, Laure, Fortner, Renee, Gapstur, Susan M., Gaudet, Mia M., Gram, Inger T., Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Victoria, Koh, Woon-Puay, Lacey, James V., Jr., Lee, I-Min, Lundin, Eva, Merritt, Melissa A., Onland-Moret, N. Charlotte, Peters, Ulrike, Poynter, Jenny N., Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Sjoholm, Louise K., Sieri, Sabina, Swerdlow, Anthony, Tjonneland, Anna, Travis, Ruth, Trichopoulou, Antonia, van den Brandt, Piet A., Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
- Abstract
Purpose An understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, and lifestyle factors by histologic subtype in the Ovarian Cancer Cohort Consortium (OC3). Patients and Methods Among 1.3 million women from 21 studies, 5,584 invasive epithelial ovarian cancers were identified (3,378 serous, 606 endometrioid, 331 mucinous, 269 clear cell, 1,000 other). By using competing risks Cox proportional hazards regression stratified by study and birth year and adjusted for age, parity, and oral contraceptive use, we assessed associations for all invasive cancers by histology. Heterogeneity was evaluated by likelihood ratio test. Results Most risk factors exhibited significant heterogeneity by histology. Higher parity was most strongly associated with endometrioid (relative risk [RR] per birth, 0.78; 95% CI, 0.74 to 0.83) and clear cell (RR, 0.68; 95% CI, 0.61 to 0.76) carcinomas (P value for heterogeneity [P-het] < .001). Similarly, age at menopause, endometriosis, and tubal ligation were only associated with endometrioid and clear cell tumors (P-het <= .01). Family history of breast cancer (P-het = .008) had modest heterogeneity. Smoking was associated with an increased risk of mucinous (RR per 20 pack-years, 1.26; 95% CI, 1.08 to 1.46) but a decreased risk of clear cell (RR, 0.72; 95% CI, 0.55 to 0.94) tumors (P-het = .004). Unsupervised clustering by risk factors separated endometrioid, clear cell, and low-grade serous carcinomas from high-grade serous and mucinous carcinomas. Conclusion The heterogeneous associations of risk factors with ovarian cancer subtypes emphasize the importance of conducting etiologic studies by ovarian cancer subtypes. Most established risk factors were more strongly associated with nonserous carcinomas, which demonstrate challenges for risk prediction of serous cancers, the most fatal subtype. (C) 2016 by Ameri
- Published
- 2016
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42. Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium
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Cardiovasculaire Epi Team 3, Circulatory Health, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Brain, Wentzensen, Nicolas, Poole, Elizabeth M, Trabert, Britton, White, Emily, Arslan, Alan A, Patel, Alpa V, Setiawan, V Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A, Buring, Julie, Butler, Lesley M, Chamosa, Saioa, Clendenen, Tess V, Dossus, Laure, Fortner, Renee, Gapstur, Susan M, Gaudet, Mia M, Gram, Inger T, Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Victoria, Koh, Woon-Puay, Lacey, James V, Lee, I-Min, Lundin, Eva, Merritt, Melissa A, Onland-Moret, N Charlotte, Peters, Ulrike, Poynter, Jenny N, Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Sjöholm, Louise K, Sieri, Sabina, Swerdlow, Anthony, Tjonneland, Anna, Travis, Ruth, Trichopoulou, Antonia, van den Brandt, Piet A, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, Cardiovasculaire Epi Team 3, Circulatory Health, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Brain, Wentzensen, Nicolas, Poole, Elizabeth M, Trabert, Britton, White, Emily, Arslan, Alan A, Patel, Alpa V, Setiawan, V Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A, Buring, Julie, Butler, Lesley M, Chamosa, Saioa, Clendenen, Tess V, Dossus, Laure, Fortner, Renee, Gapstur, Susan M, Gaudet, Mia M, Gram, Inger T, Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Victoria, Koh, Woon-Puay, Lacey, James V, Lee, I-Min, Lundin, Eva, Merritt, Melissa A, Onland-Moret, N Charlotte, Peters, Ulrike, Poynter, Jenny N, Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Sjöholm, Louise K, Sieri, Sabina, Swerdlow, Anthony, Tjonneland, Anna, Travis, Ruth, Trichopoulou, Antonia, van den Brandt, Piet A, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S
- Published
- 2016
43. Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium
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Wentzensen, Nicolas, primary, Poole, Elizabeth M., additional, Trabert, Britton, additional, White, Emily, additional, Arslan, Alan A., additional, Patel, Alpa V., additional, Setiawan, V. Wendy, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Adami, Hans-Olov, additional, Black, Amanda, additional, Bernstein, Leslie, additional, Brinton, Louise A., additional, Buring, Julie, additional, Butler, Lesley M., additional, Chamosa, Saioa, additional, Clendenen, Tess V., additional, Dossus, Laure, additional, Fortner, Renee, additional, Gapstur, Susan M., additional, Gaudet, Mia M., additional, Gram, Inger T., additional, Hartge, Patricia, additional, Hoffman-Bolton, Judith, additional, Idahl, Annika, additional, Jones, Michael, additional, Kaaks, Rudolf, additional, Kirsh, Victoria, additional, Koh, Woon-Puay, additional, Lacey, James V., additional, Lee, I-Min, additional, Lundin, Eva, additional, Merritt, Melissa A., additional, Onland-Moret, N. Charlotte, additional, Peters, Ulrike, additional, Poynter, Jenny N., additional, Rinaldi, Sabina, additional, Robien, Kim, additional, Rohan, Thomas, additional, Sandler, Dale P., additional, Schairer, Catherine, additional, Schouten, Leo J., additional, Sjöholm, Louise K., additional, Sieri, Sabina, additional, Swerdlow, Anthony, additional, Tjonneland, Anna, additional, Travis, Ruth, additional, Trichopoulou, Antonia, additional, van den Brandt, Piet A., additional, Wilkens, Lynne, additional, Wolk, Alicja, additional, Yang, Hannah P., additional, Zeleniuch-Jacquotte, Anne, additional, and Tworoger, Shelley S., additional
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- 2016
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44. Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer : a nested case-control study
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Clendenen, Tess V., Ge, Wenzhen, Koenig, Karen L., Axelsson, Tomas, Liu, Mengling, Afanasyeva, Yelena, Andersson, Anne, Arslan, Alan A., Chen, Yu, Hallmans, Göran, Lenner, Per, Kirchhoff, Tomas, Lundin, Eva, Shore, Roy E., Sund, Malin, Zeleniuch-Jacquotte, Anne, Clendenen, Tess V., Ge, Wenzhen, Koenig, Karen L., Axelsson, Tomas, Liu, Mengling, Afanasyeva, Yelena, Andersson, Anne, Arslan, Alan A., Chen, Yu, Hallmans, Göran, Lenner, Per, Kirchhoff, Tomas, Lundin, Eva, Shore, Roy E., Sund, Malin, and Zeleniuch-Jacquotte, Anne
- Abstract
Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the retinoid X receptor alpha (RXRA) gene which may be a key vitamin D pathway gene. We conducted a nested case-control study of 734 cases and 1435 individually matched controls from a population-based prospective cohort study, the Northern Sweden Mammary Screening Cohort. Tag and functional SNPs were genotyped for the VDR, cytochrome p450 24A1 (CYP24A1), and RXRA genes. We also genotyped specific SNPs in four other genes related to vitamin D metabolism and signaling (GC/VDBP, CYP2R1, DHCR7, and CYP27B1). SNPs in the CYP2R1, DHCR7, and VDBP gene regions that were associated with circulating 25(OH) D concentration in GWAS were also associated with plasma 25(OH) D in our study (p-trend < 0.005). After taking into account the false discovery rate, these SNPs were not significantly associated with breast cancer risk, nor were any of the other SNPs or haplotypes in VDR, RXRA, and CYP24A1. We observed no statistically significant associations between polymorphisms or haplotypes in key vitamin D-related genes and risk of breast cancer. These results, combined with the observation in this cohort and most other prospective studies of no association of circulating 25(OH) D with breast cancer risk, do not support an association between vitamin D and breast cancer risk.
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- 2015
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45. Ovarian cancer risk factors by histologic subtypes : evidence for etiologic heterogeneity
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Wentzensen, Nicolas A., Poole, Elizabeth, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, White, Emily, Adami, Hans-Olov, Brinton, Louise A., Bernstein, Leslie, Buring, Julie, Butler, Lesley M., Chamosa, Saioa, Clendenen, Tess V., Dossus, Laure, Fortner, Renee, Gapstur, Susan M., Gaudet, Mia M., Gram, Inger Torhild, Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Vivki, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa, Peters, Ulrike, Poynter, Jenny, Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P., Schouten, Leo J., Sjöholm, Louise, Sieri, Sabina, Swerdlow, Anthony, Tjønneland, Anne, Trabert, Britton, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Wentzensen, Nicolas A., Poole, Elizabeth, Arslan, Alan A., Patel, Alpa V., Setiawan, V. Wendy, Visvanathan, Kala, Weiderpass, Elisabete, White, Emily, Adami, Hans-Olov, Brinton, Louise A., Bernstein, Leslie, Buring, Julie, Butler, Lesley M., Chamosa, Saioa, Clendenen, Tess V., Dossus, Laure, Fortner, Renee, Gapstur, Susan M., Gaudet, Mia M., Gram, Inger Torhild, Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Jones, Michael, Kaaks, Rudolf, Kirsh, Vivki, Koh, Woon-Puay, Lacey, James V., Lee, I-Min, Lundin, Eva, Merritt, Melissa, Peters, Ulrike, Poynter, Jenny, Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sandler, Dale P., Schouten, Leo J., Sjöholm, Louise, Sieri, Sabina, Swerdlow, Anthony, Tjønneland, Anne, Trabert, Britton, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P., Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
- Abstract
Supplement: 15 Meeting Abstract: 854
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- 2015
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46. Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study
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Clendenen, Tess V., primary, Ge, Wenzhen, additional, Koenig, Karen L., additional, Axelsson, Tomas, additional, Liu, Mengling, additional, Afanasyeva, Yelena, additional, Andersson, Anne, additional, Arslan, Alan A., additional, Chen, Yu, additional, Hallmans, Göran, additional, Lenner, Per, additional, Kirchhoff, Tomas, additional, Lundin, Eva, additional, Shore, Roy E., additional, Sund, Malin, additional, and Zeleniuch-Jacquotte, Anne, additional
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- 2015
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47. Genotyping of Single Nucleotide Polymorphisms in DNA Isolated from Serum Using Sequenom MassARRAY Technology
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Clendenen, Tess V., primary, Rendleman, Justin, additional, Ge, Wenzhen, additional, Koenig, Karen L., additional, Wirgin, Isaac, additional, Currie, Diane, additional, Shore, Roy E., additional, Kirchhoff, Tomas, additional, and Zeleniuch-Jacquotte, Anne, additional
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- 2015
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48. Abstract 854: Ovarian cancer risk factors by histologic subtypes: evidence for etiologic heterogeneity
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Wentzensen, Nicolas A., primary, Poole, Elizabeth, additional, Arslan, Alan A., additional, Patel, Alpa V., additional, Setiawan, V Wendy, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, White, Emily, additional, Adami, Hans-Olov, additional, Brinton, Louise A., additional, Bernstein, Leslie, additional, Buring, Julie, additional, Butler, Lesley M., additional, Chamosa, Saioa, additional, Clendenen, Tess V., additional, Dossus, Laure, additional, Fortner, Renee, additional, Gapstur, Susan M., additional, Gaudet, Mia M., additional, Gram, Inger Torhild, additional, Hartge, Patricia, additional, Hoffman-Bolton, Judith, additional, Idahl, Annika, additional, Jones, Michael, additional, Kaaks, Rudolf, additional, Kirsh, Vivki, additional, Koh, Woon-Puay, additional, Lacey, James V., additional, Lee, I-Min, additional, Lundin, Eva, additional, Merritt, Melissa, additional, Peters, Ulrike, additional, Poynter, Jenny, additional, Rinaldi, Sabina, additional, Robien, Kim, additional, Rohan, Thomas, additional, Sandler, Dale P., additional, Schouten, Leo J., additional, Sjöholm, Louise, additional, Sieri, Sabina, additional, Swerdlow, Anthony, additional, Tjønneland, Anne, additional, Trabert, Britton, additional, Wilkens, Lynne, additional, Wolk, Alicja, additional, Yang, Hannah P., additional, Zeleniuch-Jacquotte, Anne, additional, and Tworoger, Shelley S., additional
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- 2015
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49. Endogenous hormones in mid‐life and later‐life subjective memory impairment in women.
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Sharma, Sneha, Clendenen, Tess V, Wu, Fen, Afanasyeva, Yelena, Koenig, Karen L, Zeleniuch‐Jacquotte, Anne, and Chen, Yu
- Abstract
Background: Reproductive hormones may impact cognition in women. Recent literature suggests that subjective memory complaints (SMCs) can be an early indicator of cognitive impairment. However, epidemiologic data are mixed, with few prospective studies exploring endogenous sex hormones in relation to later‐life SMCs. Assessing this potential association may elucidate an etiology of risk for cognitive impairment in women. Method: We included 616 premenopausal and 102 postmenopausal women from the New York University Women's Health Study (NYUWHS), a prospective cohort study with blood samples collected at enrollment (1985‐91) and over 35 years of follow‐up to collect health and lifestyle information. Women were ineligible for inclusion in the cohort if they used hormone medications or were pregnant 6 months prior to enrollment. Healthy controls from prior NYUWHS case‐control studies were eligible for participation in this study if their baseline blood sample had already been used to measure circulating hormones, and they responded to at least one of two follow‐up questionnaires (2018‐present) featuring 6 questions about SMCs. Multivariate logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association of baseline hormones with subsequent SMCs, adjusting for age, race, education, original case‐control study, and body mass index (BMI) in a separate model. Result: Androstenedione, testosterone, dehydroepiandrosterone sulfate (DHEAS), and sex hormone binding globulin (SHBG) were measured in samples collected at baseline for pre‐ and post‐menopausal women; estradiol and estrone were also measured in postmenopausal women. There were no significant associations between premenopausal circulating hormones or SHBG and SMCs. Postmenopausal hormones were inversely associated with SMCs, including in age and BMI‐adjusted models: ORs (95% CIs) for SMCs associated with doubling in testosterone and estradiol were 0.58 (0.35‐0.95) and 0.39 (0.17‐0.90), respectively. Conclusion: Higher postmenopausal concentrations of testosterone and estradiol are inversely associated with risk of later‐life SMCs in women. [ABSTRACT FROM AUTHOR]
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- 2023
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50. Circulating levels of 25-hydroxyvitamin D and risk of breast cancer : a nested case-control study
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Scarmo, Stephanie, Afanasyeva, Yelena, Lenner, Per, Koenig, Karen L, Horst, Ronald L, Clendenen, Tess V, Arslan, Alan A, Chen, Yu, Hallmans, Göran, Lundin, Eva, Rinaldi, Sabina, Toniolo, Paolo, Shore, Roy E, Zeleniuch-Jacquotte, Anne, Scarmo, Stephanie, Afanasyeva, Yelena, Lenner, Per, Koenig, Karen L, Horst, Ronald L, Clendenen, Tess V, Arslan, Alan A, Chen, Yu, Hallmans, Göran, Lundin, Eva, Rinaldi, Sabina, Toniolo, Paolo, Shore, Roy E, and Zeleniuch-Jacquotte, Anne
- Abstract
Introduction: Experimental evidence suggests a protective role for circulating 25-hydroxyvitamin D (25(OH) D) in breast cancer development, but the results of epidemiological studies have been inconsistent. Methods: We conducted a case-control study nested within two prospective cohorts, the New York University Women's Health Study and the Northern Sweden Mammary Screening Cohort. Blood samples were collected at enrollment, and women were followed up for breast cancer ascertainment. In total, 1,585 incident breast cancer cases were individually-matched to 2,940 controls. Of these subjects, 678 cases and 1,208 controls contributed two repeat blood samples, at least one year apart. Circulating levels of 25(OH) D were measured, and multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: No association was observed between circulating levels of 25(OH) D and overall breast cancer risk (multivariate-adjusted model OR = 0.94, 95% CI = 0.76-1.16 for the highest vs. lowest quintile, ptrend = 0.30). The temporal reliability of 25(OH)D measured in repeat blood samples was high (intraclass correlation coefficients for season-adjusted 25(OH) D > 0.70). An inverse association between 25(OH) D levels and breast cancer risk was observed among women who were = 45 years of age (ORQ5-Q1 = 0.48, 95% CI = 0.30-0.79, ptrend = 0.01) or premenopausal at enrollment (ORQ5-Q1 = 0.67, 95% CI = 0.48-0.92, ptrend = 0.03). Conclusions: Circulating 25(OH) D levels were not associated with breast cancer risk overall, although we could not exclude the possibility of a protective effect in younger women. Recommendations regarding vitamin D supplementation should be based on considerations other than breast cancer prevention.
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- 2013
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