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40 results on '"Clemson, Barry A."'

1. The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial

Author

Nassif, Michael E., Windsor, Sheryl L., Borlaug, Barry A., Kitzman, Dalane W., Shah, Sanjiv J., Tang, Fengming, Khariton, Yevgeniy, Malik, Ali O., Khumri, Taiyeb, Umpierrez, Guillermo, Lamba, Sumant, Sharma, Kavita, Khan, Sadiya S., Chandra, Lokesh, Gordon, Robert A., Ryan, John J., Chaudhry, Sunit-Preet, Joseph, Susan M., Chow, Chen H., Kanwar, Manreet K., Pursley, Michael, Siraj, Elias S., Lewis, Gregory D., Clemson, Barry S., Fong, Michael, and Kosiborod, Mikhail N.

Published
2021
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2. Coming of Age of the Family CReWS: A Ballet in Three Acts.

Author

Pennsylvania State Univ., University Park. Center for Cooperative Research with Schools., Hayman, John L., and Clemson, Barry A.

Abstract

The Center for Cooperative Research with Schools (CReWS) contracted to develop a management information system (MIS) for the National Regional Resources Center of Pennsylvania (NRRCP). The system was originally intended to transform NRRCP data into management--oriented information to support decision-making within the agency. After a year's work, however, the NRRCP was pressured by its funding sources for accountability data and thus requested the fast delivery of a completely different MIS stressing project monitoring, cost analysis, and benefit assessment. The resulting MIS generated voluminous reports, but little useful information, and the cost in staff time was high. CReWS's experience has led to the following four conclusions. First, the demand for accountability generally leads to detailed but incomprehensible reports. Second, a useful MIS cannot be developed until the agency first clearly defines its goals. Third, the expected benefits of new management tools are usually unrealistic. Finally, information and management consultants should be wary of taking the practitioner's word for what he needs. An objective need assessment is more likely to result in the production of a useful, relevant management system. (PB)

Published
1974

14. Beyond Management Information Systems.

Author

Clemson, Barry

Abstract

Management information systems fail because they are based on the assumption that more facts are needed and they overtax computer systems. The alternative proposed here is much smaller (in data banks and dollars) than conventional systems and is designed to aid decision making rather than to build banks of facts. (Author/IRT)

Published
1978

15. Harnessing the Computer in Educational Management.

Author

Clemson, Barry

Abstract

The proper function of the computer is as a filter to suppress irrelevant data and highlight critical data, to make short-term projections, to display the dynamics of system interactions, and to allow managers and teachers to interact with models of the system. Outlines the components of such a system. (Author/IRT)

Published
1980

22. Coronary Plaque Morphology and Frequency of Ulceration Distant From Culprit Lesions in Patients With Unstable and Stable Presentation

Author

Schoenhagen, Paul, primary, Stone, Gregg W., additional, Nissen, Steven E., additional, Grines, Cindy L., additional, Griffin, John, additional, Clemson, Barry S., additional, Vince, D. Geoffrey, additional, Ziada, Khaled, additional, Crowe, Timothy, additional, Apperson-Hanson, Carolyn, additional, Kapadia, Samir R., additional, and Tuzcu, E. Murat, additional

Published
2003
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25. Effectiveness and safety of diltiazem or lisinopril in treatment of hypertension after heart transplantation Results of a prospective, randomized multicenter trial

Author

Brozena, Susan C., primary, Johnson, Maryl R., additional, Ventura, Hector, additional, Hobbs, Robert, additional, Miller, Leslie, additional, Olivari, Maria Teresa, additional, Clemson, Barry, additional, Bourge, Robert, additional, Quigg, Rebecca, additional, Mills, Roger M., additional, and Naftel, David, additional

Published
1996
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36. Regulation of tissue noradrenaline in the rat myocardial infarction model of chronic heart failure.

Author

Zelis, Robert, Clemson, Barry, Baily, Robert, and Davis, Dwight

Abstract

The aim was to evaluate mechanisms regulating tissue noradrenaline in congestive heart failure. Methods: Tissue noradrenaline was measured in the conscious post myocardial infarction rat model of congestive heart failure and in sham operated rats (1) under control conditions, (2) 6 h after inhibition of tyrosine hydroxylase by the intraperitoneal administration of α-methyl-paratyrosine (AMPT) (100 mg·kg−1 every 2 h), (3) 6 h after AMPT with desipramine pretreatment (0.3 mg·kg−), and (4) following exhaustive exercise after AMPT. Tissue noradrenaline was extracted with perchloric acid and measured by high performance liquid chromatography with electrochemical detection. Results: In control animals without drug, tissue noradrenaline concentration was lower in the following tissues in the rats with myocardial infarction compared with the sham operated group: left and right ventricles, spleen, soleus and white gastrocnemius muscles, kidney cortex, and tail artery. After AMPT, tissue noradrenaline concentration in the sham operated group was significantly lower than control; in the myocardial infarction group the fall in noradrenaline was only significant in the kidney, and group differences were no longer present. In the sham operated animals, coadministration of desipramine with AMPT attenuated the fall in tissue noradrenaline caused by AMPT in the heart and spleen. With exercise to exhaustion, cardiac noradrenaline was lower in rats with myocardial infarction than in sham operated rats, but higher in the soleus muscle. Conclusions: These data suggest that tissue noradrenaline depletion in congestive heart failure is not isolated to the heart, and it occurs despite activation of mechanisms that might be operating to conserve neuronal noradrenaline. One mechanism may be reduced organ blood flow to retard diffusion of noradrenaline into the circulation. If this increases interstitial noradrenaline concentration, it would facilitate prejunctional α2 receptor restraint on noradrenaline release. Metabolic coronary vasdilatation during exercise reverses this process, and makes the heart most susceptible to noradrenaline depletion in congestive heart failure.Cardiovascular Research 1992;26:933–938 [ABSTRACT FROM PUBLISHER]

Published
1992

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