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1. Assessing bidirectional associations between cognitive impairment and late age‐related macular degeneration in the Age‐Related Eye Disease Study 2

Author

Le, Jimmy T, Agrón, Elvira, Keenan, Tiarnan DL, Clemons, Traci E, Brenowitz, Willa D, Yaffe, Kristine, Chew, Emily Y, and Group, for the AREDS2 Research

Subjects
Aging, Neurodegenerative, Behavioral and Social Science, Macular Degeneration, Clinical Research, Eye Disease and Disorders of Vision, Clinical Trials and Supportive Activities, Rehabilitation, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Eye, Aged, Cognitive Dysfunction, Disease Progression, Humans, Proportional Hazards Models, age-related macular degeneration, Alzheimer's disease, cognitive impairment, eyes, older adults, ophthalmology, AREDS2 Research Group, Clinical Sciences, Neurosciences, Geriatrics
Abstract

IntroductionWe aimed to investigate bidirectional associations between cognitive impairment and late age-related macular degeneration (AMD).MethodsParticipants in the Age-Related Eye Disease Study 2 (AREDS2) received annual eye examinations and cognitive function testing (e.g., Modified Telephone Interview for Cognitive Status [TICS-M]). We examined bidirectional associations between cognitive impairment (e.g., a TICS-M score

Published
2022

4. Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration Age-Related Eye Disease Study 2 Report No. 17

Author

Yu, Jeannette J, Agrón, Elvira, Clemons, Traci E, Domalpally, Amitha, van Asten, Freekje, Keenan, Tiarnan D, Cukras, Catherine, Chew, Emily Y, Ferris, Frederick L, SanGiovanni, John Paul, Clemons, Traci, Lindblad, Anne, Lindblad, Robert, Shah, Nilay, Sperduto, Robert, McBee, Wendy, Gensler, Gary, Harrington, Molly, Henning, Alice, Jones, Katrina, Thotapally, Kumar, Tull, Diana, Watson, Valerie, Williams, Kayla, Gentry, Christina, Kaufman, Francine, Morrison, Chris, Saverino, Elizabeth, Schenning, Sherrie, Blodi, Barbara, Danis, Ronald P, Davis, Matthew, Glander, Kathy, Guilfoil, Gregory, Hubbard, Larry D, Johnson, Kristine, Klein, Ronald, Nardi, Barbara, Neider, Michael, Robinson, Nancy, Rosensteel, Eileen, Wabers, Hugh, Zhang, Grace, Ruby, Alan J, Capone, Antonio, Dass, Bawa, Drenser, Kimberly, Garretson, Bruce R, Hassan, Tarek S, Trese, Michael, Williams, George A, Wolfe, Jeremy, Bell, Tina, Zajechowski, Mary, Bezaire, Dennis, McIver, Fran, Medina, Anthony, Pagett, Jackie, Smith, Stephanie Hatch, Swartz, Lynn, Treuter, Tom, Antoszyk, Andrew, Brown, Justin, Browning, David J, Holland, Walter, Karow, Angella, Stalford, Kelly, Price, Angela, Ennis, Sarah, Fredenberg, Sherry, Herby, Jenna, Balasubramaniam, Uma, Clark, Loraine, McClain, Donna, McOwen, Michael, Watson, Lynn, Klein, Michael, Bailey, Steven T, Hwang, Thomas J, Lauer, Andreas, Stout, J Timothy, McCollum, Patty, Johnson, Milt, Rice, Patrick B, Kim, Ivana, Loewenstein, John, Miller, Joan, Sobrin, Lucia, Young, Lucy, Sullivan, Jacqueline, Houlihan, Patricia, Merry, Linda, Lane, Ann Marie, Bator, Ursula Lord, Evans, Claudia, Brett, Sarah, and Callahan, Charleen

Subjects
Prevention, Clinical Research, Neurodegenerative, Clinical Trials and Supportive Activities, Eye Disease and Disorders of Vision, Macular Degeneration, Aging, Genetics, Eye, Aged, Aged, 80 and over, Disease Progression, Female, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Prospective Studies, Proteins, Retinal Detachment, Retinal Drusen, Retinal Pigment Epithelium, Retrospective Studies, Time Factors, Visual Acuity, Age-Related Eye Disease Study 2 Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

PurposeTo investigate the natural history and genetic associations of drusenoid pigment epithelial detachment (DPED) associated with age-related macular degeneration (AMD).DesignRetrospective analysis of a prospective cohort study.ParticipantsOf the 4203 Age-Related Eye Disease Study 2 (AREDS2) participants, 391 eyes (325 participants) had DPED without late AMD at the time of DPED detection. Genetic analyses included 120 white AREDS2 participants and 145 Age-Related Eye Disease Study (AREDS) participants with DPED.MethodsBaseline and annual stereoscopic fundus photographs were graded centrally to detect DPED, a well-defined yellow elevated mound of confluent drusen ≥433 μm in diameter, and to evaluate progression rates to late AMD: geographic atrophy (GA) and neovascular (NV)-AMD. Five single nucleotide polymorphisms (CFH [rs10611670], C3 [rs2230199], CFI [rs10033900], C2/CFB [rs114254831], ARMS2 [rs10490924]) and genetic risk score (GRS) group were investigated for association with DPED development. Kaplan-Meier analyses and multivariable proportional hazard regressions were performed.Main outcome measuresProgression rates to late AMD and decrease of ≥3 lines in visual acuity (VA) from the time of DPED detection; association of rate of DPED development with genotype.ResultsMean (standard deviation [SD]) follow-up time from DPED detection was 4.7 (0.9) years. DPED was associated with increased risk of progression to late AMD (hazard ratio [HR], 2.36; 95% confidence interval [CI], 1.98-2.82; P < 0.001); 67% of eyes progressed to late AMD 5 years after DPED detection. Drusenoid pigment epithelial detachment was associated with increased risk of ≥3 lines of VA loss (HR, 3.08; CI, 2.41-3.93; P < 0.001) with 46% of eyes experiencing vision loss at 5 years (with or without progression to late AMD). ARMS2 risk alleles (1 vs. 0: HR, 2.72, CI, 1.58-4.70; 2 vs. 0: HR, 3.16, CI, 1.60-6.21, P < 0.001) and increasing GRS group (4 vs. 1) (HR, 12.17, CI, 3.66-40.45, P < 0.001) were significantly associated with DPED development in AREDS. There were no significant genetic results in AREDS2.ConclusionsThis study replicates the results of previous natural history studies of eyes with DPED including the high rates of progression to late AMD and vision loss (regardless of progression to late AMD). The genetic associations are consistent with genes associated with AMD progression.

Published
2019

5. Progression of Geographic Atrophy in Age-related Macular Degeneration AREDS2 Report Number 16

Author

Keenan, Tiarnan D, Agrón, Elvira, Domalpally, Amitha, Clemons, Traci E, van Asten, Freekje, Wong, Wai T, Danis, Ronald G, Sadda, SriniVas, Rosenfeld, Philip J, Klein, Michael L, Ratnapriya, Rinki, Swaroop, Anand, Ferris, Frederick L, Chew, Emily Y, SanGiovanni, John Paul, Clemons, Traci, Lindblad, Anne, Lindblad, Robert, Shah, Nilay, Sperduto, Robert, McBee, Wendy, Gensler, Gary, Harrington, Molly, Henning, Alice, Jones, Katrina, Thotapally, Kumar, Tull, Diana, Watson, Valerie, Williams, Kayla, Gentry, Christina, Kaufman, Francine, Morrison, Chris, Saverino, Elizabeth, Schenning, Sherrie, Blodi, Barbara, Danis, Ronald P, Davis, Matthew, Glander, Kathy, Guilfoil, Gregory, Hubbard, Larry D, Johnson, Kristine, Klein, Ronald, Nardi, Barbara, Neider, Michael, Robinson, Nancy, Rosensteel, Eileen, Wabers, Hugh, Zhang, Grace, Ruby, Alan J, Capone, Antonio, Dass, Bawa, Drenser, Kimberly, Garretson, Bruce R, Hassan, Tarek S, Trese, Michael, Williams, George A, Wolfe, Jeremy, Bell, Tina, Zajechowski, Mary, Bezaire, Dennis, McIver, Fran, Medina, Anthony, Pagett, Jackie, Smith, Stephanie Hatch, Swartz, Lynn, Treuter, Tom, Antoszyk, Andrew, Brown, Justin, Browning, David J, Holland, Walter, Karow, Angella, Stalford, Kelly, Price, Angela, Ennis, Sarah, Fredenberg, Sherry, Herby, Jenna, Balasubramaniam, Uma, Clark, Loraine, McClain, Donna, McOwen, Michael, Watson, Lynn, Klein, Michael, Bailey, Steven T, Hwang, Thomas J, Lauer, Andreas, Stout, J Timothy, McCollum, Patty, Johnson, Milt, Rice, Patrick B, Kim, Ivana, Loewenstein, John, Miller, Joan, Sobrin, Lucia, Young, Lucy, Sullivan, Jacqueline, and Houlihan, Patricia

Subjects
Prevention, Genetics, Neurodegenerative, Aging, Eye Disease and Disorders of Vision, Macular Degeneration, Eye, Aged, Aged, 80 and over, Disease Progression, Docosahexaenoic Acids, Drug Therapy, Combination, Eicosapentaenoic Acid, Female, Geographic Atrophy, Humans, Lutein, Male, Middle Aged, Photography, Prospective Studies, Visual Acuity, Zeaxanthins, AREDS2 Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

PurposeTo analyze the prevalence, incidence, and clinical characteristics of eyes with geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and genetic factors affecting enlargement.DesignProspective cohort study within a controlled clinical trial.ParticipantsAge-Related Eye Disease Study 2 (AREDS2) participants, aged 50-85 years.MethodsBaseline and annual stereoscopic color fundus photographs were evaluated for GA presence and area. Analyses included GA prevalence and incidence rates, Kaplan-Meier rates, mixed-model regression, and multivariable analysis of the square root of GA, area adjusted for covariates, including clinical/imaging characteristics and genotype.Main outcome measures(1) Presence or development of GA; (2) change in the square root of GA area over time.ResultsAt baseline, 517 eyes (6.2%) of 411 participants (9.8%) had pre-existing GA (without neovascular AMD), with the following characteristics: 33% central, 67% noncentral; and the following configurations: 36% small, 26% solid/unifocal, 24% multifocal, 9% horseshoe/ring, and 6% indeterminate. Of the remaining 6530 eyes at risk, 1099 eyes (17.3%) of 883 participants developed incident GA without prior neovascular disease during mean follow-up of 4.4 years. The Kaplan-Meier rate of incident GA was 19% of eyes at 5 years. In eyes with incident GA, 4-year risk of subsequent neovascular AMD was 29%. In eyes with incident noncentral GA, 4-year risk of central involvement was 57%. GA enlargement rate (following square root transformation) was similar in eyes with pre-existing GA (0.29 mm/year; 95% confidence interval 0.27-0.30) and incident GA (0.28 mm/year; 0.27-0.30). In the combined group, GA enlargement was significantly faster with noncentrality, multifocality, intermediate baseline size, and bilateral GA (P < 0.0001 for interaction in each case) but not with AREDS2 treatment assignment (P = 0.33) or smoking status (P = 0.05). Enlargement was significantly faster with ARMS2 risk (P < 0.0001), C3 non-risk (P = 0.0002), and APOE non-risk (P = 0.001) genotypes.ConclusionsAnalyses of AREDS2 data on natural history of GA provide representative data on GA evolution and enlargement. GA enlargement, which was influenced by lesion features, was relentless, resulting in rapid central vision loss. The genetic variants associated with faster enlargement were partially distinct from those associated with risk of incident GA. These findings are relevant to further investigations of GA pathogenesis and clinical trial planning.

Published
2018

6. Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2.

Author

Pauleikhoff, Daniel, Bonelli, Roberto, Dubis, Adam M, Gunnemann, Frederic, Rothaus, Kai, Charbel Issa, Peter, Heeren, Tjebo Fc, Peto, Tunde, Clemons, Traci E, Chew, Emily Y, Bird, Alan C, Sallo, Ferenc B, and MacTel Study Group

Subjects
MacTel Study Group, Retinal Vessels, Fundus Oculi, Macula Lutea, Humans, Disease Progression, Tomography, Optical Coherence, Fluorescein Angiography, Prognosis, Follow-Up Studies, Visual Acuity, Time Factors, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Retinal Pigment Epithelium, Retinal Telangiectasis, OCT, MacTel, ellipsoid zone, en face image, macular telangiectasia type 2, Neurodegenerative, Eye Disease and Disorders of Vision, Clinical Research, Eye, OCT, Clinical Sciences, Neurosciences, Opthalmology and Optometry, Ophthalmology & Optometry
Abstract

PurposeTo investigate the progression characteristics of ellipsoid zone (EZ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, and their relevance for visual acuity.MethodsParticipants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in Spectral-Domain Optical Coherence Tomograph (SD-OCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models.ResultsA total of 134 eyes of 70 patients were included (85 eyes with follow-up, mean 4.7 years, range: 1.4-8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm2 (p = 0.005). The progression rate was non-linear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area (b = 1.06, p

Published
2019

7. Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2 A Randomized Clinical Trial

Author

Chew, Emily Y, Clemons, Traci E, Jaffe, Glenn J, Johnson, Charles A, Farsiu, Sina, Lad, Eleonora M, Guymer, Robyn, Rosenfeld, Philip, Hubschman, Jean-Pierre, Constable, Ian, Wiley, Henry, Singerman, Lawrence J, Gillies, Mark, Comer, Grant, Blodi, Barbara, Eliott, Dean, Yan, Jiong, Bird, Alan, Friedlander, Martin, and Group, Macular Telangiectasia Type 2-Phase 2 CNTF Research

Subjects
Eye Disease and Disorders of Vision, Clinical Trials and Supportive Activities, Aging, Clinical Research, Neurosciences, Neurodegenerative, Macular Degeneration, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Eye, Aged, Cell- and Tissue-Based Therapy, Ciliary Neurotrophic Factor, Drug Implants, Electroretinography, Female, Fluorescein Angiography, Humans, Intravitreal Injections, Male, Middle Aged, Photoreceptor Cells, Vertebrate, Reading, Retina, Retinal Degeneration, Retinal Telangiectasis, Single-Blind Method, Visual Acuity, Visual Fields, Macular Telangiectasia Type 2-Phase 2 CNTF Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

PurposeTo test the effects of an encapsulated cell-based delivery of a neuroprotective agent, ciliary neurotrophic factor (CNTF), on progression of macular telangiectasia type 2, a neurodegenerative disease with no proven effective therapy.DesignRandomized sham-controlled clinical trial.ParticipantsNinety-nine study eyes of 67 eligible participants were enrolled.MethodsSingle-masked randomized clinical trial of 24 months' duration conducted from May 2014 through April 2017 in 11 clinical centers of retinal specialists in the United States and Australia. Participants were randomized 1:1 to surgical implantation of intravitreal sustained delivery of human CNTF versus a sham procedure.Main outcome measuresThe primary outcome was the difference in the area of neurodegeneration as measured in the area of the ellipsoid zone disruption (or photoreceptor loss) measured on spectral-domain (SD) OCT images at 24 months from baseline between the treated and untreated groups. Secondary outcomes included comparison of visual function changes between treatment groups.ResultsAmong the 67 participants who were randomized (mean age, 62±8.9 years; 41 women [61%]; 58 white persons [86%]), 65 (97%) completed the study. Two participants (3 study eyes) died and 3 participants (4 eyes) were found ineligible. The eyes receiving sham treatment had 31% greater progression of neurodegeneration than the CNTF-treated eyes. The difference in mean area of photoreceptor loss was 0.05±0.03 mm2 (P = 0.04) at 24 months. Retinal sensitivity changes, measured using microperimetry, were correlated highly with the changes in the area of photoreceptor loss (r = 0.86; P < 0.0001). The mean retinal sensitivity loss of the sham group was 45% greater than that of the treated group (decrease, 15.81±8.93 dB; P = 0.07). Reading speed deteriorated in the sham group (-13.9 words per minute) with no loss in the treated group (P = 0.02). Serious adverse ocular effects were found in 2 of 51 persons (4%) in the sham group and 2 of 48 persons (4%) in the treated group.ConclusionsIn participants with macular telangiectasia type 2, a surgical implant that released CNTF into the vitreous cavity, compared with a sham procedure, slowed the progression of retinal degeneration. Further research is needed to assess longer-term clinical outcomes and safety.

Published
2019

9. Machine Learning OCT Predictors of Progression from Intermediate Age-Related Macular Degeneration to Geographic Atrophy and Vision Loss

Author

Toth, Cynthia A., Wong, Wai, Huang, Thomas, Hubbard, G. Baker, Srivastava, Sunil, McCall, Michelle, Winter, Katrina, Sarin, Neeru, Hall, Katherine, McCollum, Patti, Curtis, Linda, Schuman, Stefanie, Chiu, Stephanie J., Farsiu, Sina, Tai, Vincent, Clemons, Traci, Chew, Emily, Lad, Eleonora M., Sleiman, Karim, Banks, David L., Hariharan, Sanjay, Herrmann, Rolf, Dauletbekov, Daniyar, Giani, Andrea, Chong, Victor, and Chew, Emily Y.

Published
2022
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11. The impact of zinc and folic acid supplementation on sperm DNA methylation: results from the folic acid and zinc supplementation randomized clinical trial (FAZST)

Author

Jenkins, Tim, Aston, Kenneth, Carrell, Douglas, DeVilbiss, Elizabeth, Sjaarda, Lindsey, Perkins, Neil, Mills, James L., Chen, Zhen, Sparks, Amy, Clemons, Traci, Chaney, Kayla, Peterson, C. Matthew, Emery, Benjamin, Hotaling, Jim, Johnstone, Erica, Schisterman, Enrique, and Mumford, Sunni L.

Published
2022
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13. CHARACTERISTICS OF PIGMENTED LESIONS IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA

Author

Leung, Irene, Sallo, Ferenc B, Bonelli, Roberto, Clemons, Traci E, Pauleikhoff, Daniel, Chew, Emily Y, Bird, Alan C, and Peto, Tunde

Subjects
Rare Diseases, Clinical Research, Macular Degeneration, Neurodegenerative, Eye Disease and Disorders of Vision, Neurosciences, Aging, Eye, Female, Fluorescein Angiography, Follow-Up Studies, Fundus Oculi, Humans, Macula Lutea, Male, Middle Aged, Ophthalmoscopy, Prospective Studies, Retinal Pigment Epithelium, Retinal Pigments, Telangiectasia, Hereditary Hemorrhagic, Time Factors, Tomography, Optical Coherence, Visual Acuity, MacTel Study Group, Opthalmology and Optometry, Ophthalmology & Optometry
Abstract

PURPOSE:Pigment in the midretina is a characteristic sign in Type 2 idiopathic macular telangiectasia (MacTel) and is considered to characterize the late stage of the disease. Our aim was to investigate its incidence, and relationship with risk factors for MacTel, including outer retinal vascularization and subretinal neovascular proliferation (SRNV). METHODS:Pigment extent was measured in fundus autofluorescence images of 150 eyes of 75 MacTel probands, using the Region Finder tool of Heidelberg Eye Explorer. A linear mixed model was used to analyze the dynamics of pigment and its associations with other features of the phenotype. The relative incidence of pigment and of outer retinal outer retinal vascularization and SRNV was analyzed within the full MacTel Study cohort (1,244 probands). RESULTS:Mean pigment area at baseline was 0.157 mm (range = 0-1.295 mm, SD = 0.228 mm, n = 101). Progression demonstrated a nonlinear pattern (P < 0.001) at an overall rate of 0.0177 mm/year and was associated with the initial plaque size and with SRNV. There was a strong correlation between fellow eyes (P ≤ 0.0001). In approximately 25% of all SRNV cases, SRNV may coincide with or precede pigment. CONCLUSION:Our data may be useful for refining the current system for staging disease severity in MacTel.

Published
2018

14. Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17

Author

Chew, Emily Y., Ferris, Frederick L., III, SanGiovanni, John Paul, Agrón, Elvira, Clemons, Traci, Lindblad, Anne, Lindblad, Robert, Shah, Nilay, Sperduto, Robert, McBee, Wendy, Gensler, Gary, Harrington, Molly, Henning, Alice, Jones, Katrina, Thotapally, Kumar, Tull, Diana, Watson, Valerie, Williams, Kayla, Gentry, Christina, Kaufman, Francine, Morrison, Chris, Saverino, Elizabeth, Schenning, Sherrie, Blodi, Barbara, Danis, Ronald P., Davis, Matthew, Domalpally, Amitha, Glander, Kathy, Guilfoil, Gregory, Hubbard, Larry D., Johnson, Kristine, Klein, Ronald, Nardi, Barbara, Neider, Michael, Robinson, Nancy, Rosensteel, Eileen, Wabers, Hugh, Zhang, Grace, Ruby, Alan J., Capone, Antonio, Jr., Dass, Bawa, Drenser, Kimberly, Garretson, Bruce R., Hassan, Tarek S., Trese, Michael, Williams, George A., Wolfe, Jeremy, Bell, Tina, Zajechowski, Mary, Bezaire, Dennis, McIver, Fran, Medina, Anthony, Pagett, Jackie, Smith, Stephanie Hatch, Swartz, Lynn, Treuter, Tom, Antoszyk, Andrew, Brown, Justin, Browning, David J., Holland, Walter, Karow, Angella, Stalford, Kelly, Price, Angela, Ennis, Sarah, Fredenberg, Sherry, Herby, Jenna, Balasubramaniam, Uma, Clark, Loraine, McClain, Donna, McOwen, Michael, Watson, Lynn, Klein, Michael, Bailey, Steven T., Hwang, Thomas J., Lauer, Andreas, Stout, J. Timothy, McCollum, Patty, Johnson, Milt, Rice, Patrick B., Kim, Ivana, Loewenstein, John, Miller, Joan, Sobrin, Lucia, Young, Lucy, Sullivan, Jacqueline, Houlihan, Patricia, Merry, Linda, Lane, Ann Marie, Bator, Ursula Lord, Evans, Claudia, Brett, Sarah, Callahan, Charleen, Grillo, Marcia, Walsh, David, Zimmerman, Kamella Lau, Fish, Gary Edd, Anand, Rajiv, Coors, Lori E., Fuller, Dwain G., Spencer, Rand, Wang, Robert C., Duignan, Karen, Arceneaux, Sally, Aguado, Hank, Hesse, Nicholas, Mackens, Michael, Swan, Brian, Wong, Wai T., Cukras, Catherine, Dalal, Monica, Jacobs-El, Naima, Meyerle, Catherine, Nicholson, Benjamin, Wiley, Henry, Shimel, Katherine Hall, Garced, Angel, Oparah, Janice, Short, Greg, Temple, Alana, Ayukawa, Babilonia, Foster, Guy, Hayes, Darryl, Koutsandreas, Dessie, Nashwinter, Roula, Rowan, John, Bono, Michael, Cunningham, Denise, Palmer, Marilois, Zetina, Alicia, Orth, David H., Rezaei, Kourous, Civantos, Joseph, Hasan, Sohail, Packo, Kirk, Figliulo, Celeste, Stanberry, Pam, Farmer, Tara, Nelson, Kiersten, Townsend-Patrick, Shannya, Rosenfeld, Philip, Chen, Royce, Doshi, Rishi, Dubovy, Sander, Kim, Brian T., Lowrance, Matthew, Moshfeghi, Andrew, Nahas, Zayna, Schienbaum, Gary, Vishak, John, Weng, Christina, Yehoshua, Zohar, Rodriguez, Belen, Rebimbas, Jose, Gleichauf, Jane, Kicak, Mike, Mena, Jason, Odem, Tim, Sferza-Camp, Elizabeth, Disgdiertt, Alicia, Oramas, Jim, Rams, Isabel, Thatcher, Stephanie, Bressler, Susan B., Bressler, Neil M., Finkelstein, Daniel, Sherman, Steven H., Solomon, Sharon, Ying, Howard S., Denbow, Rita, Phillips, Deborah, Radcliffe, Elizabeth, Belt, Judy, Cain, Dennis, Emmert, David, Herring, Mark, McDonald, Jacquelyn, Hubbard, G. Baker, Bergstrom, Chris S., Cribbs, Blaine, Hendrick, Andrew, Johnson, Brandon, Laird, Philip, Mehta, Sonia, Olsen, Timothy, Townsend, Justin, Yan, Jion, Yeh, Steven, Curtis, Linda, Brower, Judy, Yi, Hannah, Dobbs, Jannah Rutter, Jordan, Debbie, Elman, Michael J., Liss, Robert A., Starr, JoAnn, Belz, Jennifer, Putzulo, Charlene, Coffey, Teresa, Davis, Ashley, Singletary, Pamela, Andreani, Giorya Shabi, Cain, Theresa, Ketner, Daniel, Sotirakos, Peter, Chandra, Suresh, Blodi, Barbara A., Altaweel, Michael M., Gottlieb, Justin L., Ip, Michael, Nork, T. Michael, Stevens, Thomas S., Burke, Kathryn, Olson, Shelly, Dietzman, Kristine, Soderling, Barbara, Somers, Guy, Wealti, Angie, Krolnik, Denise, Peterson, John, Reed, Sandra, Friberg, Thomas, Eller, Andrew, Gallagher, Denise, Labriola, Leanne, Pokrifka, Melissa, Gedansky, Aron, Anthony, Natalie, Grzybowski, Cassandra, Matthews, Dawn, Murajda-Jumba, Sharon, Toro, Jessica, Callanan, David G., Solley, Wayne A., Williams, Patrick, Lash, Sandy, Boleman, Bob, Dock, Chris, Shami, Michel, Arrington, Brenda, Meeks, Ashaki, Margherio, Alan R., Raphaelian, Paul, Markus, Debra, Langdon, Justin, Truax, Elizabeth, Lewis, Sandy, Terry, Brad, Noffke, Amy, Oh, Kean, Sarrafizadeh, Ramin, Sneed, Scott, Hammersley, Julie, Neal, Serena, Doran, Mary, Jones, Nan, Preston, Lisa, Jessick, Heather, Marsh, Tanya Tracy, Tolentino, Michael, Berger, Adam, Hamilton, Richard, Misch, David, Moon, Suk Jin, Sutherland, Dawn, Dilts, Vera, Henderson, Sara, Medina, Esmeralda, Trueman, Donald, Holm, Laura, Strickland, Jason, Ie, Darmakusuma, Lipkowitz, Jeffrey L., Shah, Kekul B., Geraghty, Susan, Sannazzaro, Beverly, Harper, Morgan, Bayer, Krista, Lansing, Mary B., Fox, Lauren B., Lee, Rebecca, Stallman, Jay B., Jacobson, Michael, Koh, Sean, Lampert, Scott, Miller, John, Rivellese, Mark, Sharma, Atul, Stoltz, Robert A., Vanderveldt, Stephanie, Marcus, Leslie, Hendricks, Starr, Hollman, Ryan, Betanzos, Grethel, Ellorin, Leslie, Fulbright, Shelly, McCormick, Debbie, Edwards, Paul A., Hall, Julianne, Monk, Mary, Gutkowski, Melanie, Mazurek, Melina, Murphy, Janet, Gusas, Katherine, Moffett, Crystal, Burley, David, Chesney, Nicole, Kilgo, Katie, Rusinek, Brian, Stern, Bradley, Troszak, Tracy, Baker-Levingston, Rhonda, Baker, Carl W., Caldwell, Tracey, Walker, Tammy, Lambert, Lynnette F., Martin, Tracey, Palmer, Mary Jill, Williams, Tana, Novak, Michael A., Coney, Joseph, Miller, David G., Pendergast, Scott, Singerman, Lawrence, Zakov, Nicholas, Zegarra, Hernando, DuBois, Kim, Rath, Susan, Revella, Lori, Brink, Tammy, Drury, Kim, Hogue, Lisa, Ilc, Mary, Keller, Connie, McNamara, Elizabeth, Tanner, Vivian, Cunningham, Tamara, DuBois, John, Greanoff, Gregg, Nitzsche, Trina, Smith-Brewer, Sheila, Isernhagen, Ricky D., Kitchens, John W., Stone, Thomas W., Wood, William J., Holcomb, Diana, Therrien, Virginia, Buck, Michelle, Van Arsdall, Jeanne, Slade, Edward, Schneiderman, Todd E., Spinak, David J., Gaedke, Jackie, Brown, Heather Davis, Helgren, Dan, Pangelinan, Jenifer Garrison, Halperin, Lawrence, Anagnoste, Scott, Dhalla, Mandeep, Rosenberg, Krista, Taney, Barry, Thompson, W. Scott, Lopez, Jaclyn, Hamlin, Monica, Lopez, Monica, Mariano, Jamie, Quinchia, Evelyn, Aramayo, Patricia, Veksler, Rita, Lee, Michael, Dreyer, Richard, Handelman, Irvin, Ma, Colin, Peters, Mark, Hobbs, Stephen, III, Milliron, Amanda, Kopfer, Marcia, Connaughton, Michele, Hoerner, A. Christine, Logan, R. Joseph, Wohlsein, Harry J., Boyer, David, Chu, Thomas G., Dayani, Pouya, Liao, David, Novack, Roger L., Rahhal, Firas M., Roe, Richard, Tabandeh, Homayoun, Bayramyan, Janet, Gasparyan, Tammy, Hoang, Connie, Kurokouchi, Janet, Lo, Tammy Eileen, Ngo, Richard, Nguyen, Mary Ann, Peyton, Michael, Yoon, Charles, Sierra, Julio, Zamboni, Adam, Kessinger, Jeff, Protacio, Eric, Smucker, Adam, Rath, Pamela, Bergren, Robert, Doft, Bernard, Liu, Judy, Olsen, Karl, Merlotti, Lori, Ingram, Willia, Marfisi, Kellianne, Yeckel, Kimberly, Carmelo, Heather Schultz, Fec, Amanda, McBroom, Keith, Steinberg, David, Levy, Marc, Abrams, Jody, Chen, Melvin, Torres, Waldemar, Jelemensky, Peggy, Prybylski, Mark, Raphael, Tara, Appleby, Diana, Rodman, Charlotte, Sneath, Mark, Rosa, Robert H., Jr., Hoelscher, Vanessa, Castano, Adelia, Parker, Jocelyn, Hoskins, John, Anderson, Nicholas, Googe, Joseph, Jr., McMillan, Tod A., Miller, James, Jr., Perkins, Stephen, Oliver, Kristina, Beerbower, Jennifer, Gilliland, Bruce, Hunt, Cecile, Jacobus, Mike, Lince, Raul, Morris, Christopher, Oelrich, Sarah, Whetstone, Jerry, Chan, Clement K., Lin, Steven, Walther, Kim, Gonzales, Tiana, Myers, Lenise, Huff, Kenneth, Brown, David M., Chen, Eric, Benz, Matthew S., Fish, Richard H., Kim, Rosa Y., Major, James, Jr., Wong, Tien Pei, Wycoff, Charles, Cone, Cassandra, Gilaspia, Debbie Goates, Landaverde, Nubia, Smith, Robert, Zamora, Deneva, Sneed, Veronica, Vela, Melina, Kegley, Eric, Greven, Craig, Kurup, Shree, Richards, Charles, Slusher, Madison, Everhart, Cara, Fish, Joan, Clark, Mark, Miller, David, Tyler, Marshall, Jumper, J. Michael, Fu, Arthur D., Johnson, Robert N., Lujan, Brandon, McDonald, H. Richard, Rodriguez, Rosa, Ansari, Nina, Joaquin, Jeanifer, Linares, Silvia, Lopez, Lizette, Sabio, Jessica, Grout, Sean, Indermill, Chad, Urias, Yesmin, Zimmerman, Roberto, Margulies, Linda, Schmidt, Sara J., Meier, Joy L., Hadley, Sherry L., Rosenthal, William, Johnson, Barbara, Swafford, Lois, Shields, Richard, Varner, R. Scott, Rosen, Richard, Gentile, Ronald, Rivas, Melissa, Tai, Katy W., Carrasquillo-Boyd, Wanda, Masini, Robert, Stoller, Glenn, Carnevale, Ken, LaRosa, Diane M., Burger, Barbara, Conway, Tereza, Del Castillo, Carla, Diaz, Julissa, Jones, Susan, Mondoc, Nina, Balfour, Charlene, Vitha, C.H., Lutz, Jennifer, McGinley, Barbara, El Baba, Fadi, Lavorna, Ann Marie, Jones, Renee, Lewis, Jean, Tenzler, Ruth, Salvas-Mladek, Mary, Van Kesteren, Diane, McLean, W. Copley, Jr., Bridges, W. Zachery, Jr., Stone, Cameron, Ammons, Denise, Lamy, Mary, Menzel, Andrea, Raymer, Lea Doll, Campbell, Barbara, Hawkins, Lisa, Rickman, Leslie, Sherlin, Lorraine, Price, Paula, Sinyai, Albert, Kingsley, Ronald, Bradford, Reagan H., Jr., Leonard, Robert E., II, Icks, Sonny, Bergman, Vanessa, Ross, Brittany, Burris, Russ, Butt, Amanda, Richmond, Rob, Lyon, Alice, Gill, Manjot, Jampol, Lee, Mizra, Rukhsana, Rozenbajgier, Zuzanna, Chapman, Jeremy, Kaminski, Lori, Degillio, Andrea, Simjanoski, Evica, Heier, Jeffrey, Cho, Hyung, Cleary, Tina Scheufele, Goldman, Darin, Shah, Chirag, Topping, Trexler, Weber, Marissa, Wiegand, Torsten, Schindelheim, Jeremy, Bankert, Joy, Stone, Jennifer, Nowak, Alison, Chong, Sandy, Williams, Lindsay, Bennett, Steven, Donovan, Dennis, Graham, Margaret, Jones, Cullen, Fung, Anne, Bayabo, Jan-Kristine, Bosch, Razelda, Cruz, Esperanza, Emerson, Ashley, Fleming, Alycia, Barsness, Denice, Rodriguez, Jorge, Soboleva, Marina, Scott, Ingrid U., Bowie, Esther, Neely, Kimberly A., Quillen, David A., Walter, Laura, Bennett, Timothy, Strong, James, Wells, John, III, Clark, Lloyd, Johnson, David, Miller, Peggy, Taylor, Mallie, Swinford, Tiffany, Spivey, Robbin, Banach, Michael, Ho, Lawrence, Lanning, Richard, Pheasant, Thomas R., Prensky, Jay G., Truong, Steven, Teatsworth, Julia, Dietrich, Michelle, Wasilus, Ann, Miller, Ann, Rakes, Megan, Slagle, Teresa, Richards, Michelle, Schuessler, Patricia, Stover, Lacy, Beer, Paul, Falk, Naomi S., Shannon, Mary Beth, Olmeda, Jeannie, Berdeen, Don, Fisher, Joseph F., Jr., Folk, James, Russell, Stephen, Taylor, Barbara, Hinz, Connie, Walshire, Jean, Stockman, Heather, Critser, Bruce, Karakas, Stefani, Montague, Cindy, Verdick, Randy, Gupta, Omesh, Maguire, Joseph, Brady, Christopher, DeCroos, Francis Char, Dollin, Michael, Garg, Sunir, Gerstenblith, Adam, Haller, Julia, Ho, Allen C., Hsu, Jason, Kaiser, Richard, Pitcher, John, Regillo, Carl, Shah, Rajiv, Spirn, Marc, Tasman, William, Vander, James, Senderowitsch, Noga, Formoso, Michele, Markun, Michelle, George, Cedric, Centinaro, Christina, Grande, Lisa, Carey, Stefanie, Liebenbaum, Elaine, Sadda, SriniVas, Humayun, Mark, Sierra, Rachel, Corona, Elizabeth, Padilla, Margaret, Nu, Moonseok, Ramos, Sylvia, Barnett, Cullen, Currie, Glenn, Gottlieb, Cornelia, Garfinkel, Richard, Berinstein, Daniel, Colyer, Marcus, Deegan, William, III, Min-Shyue Lai, Michael, Murphy, Robert, Osman, Michael, Rivers, Michael, Sanders, Reginald, von Fricken, Manfred A., Oliver, Debbie, Kirshon, Jeanne, Snowden, Tanya Alexander, Blondo, Thomas, Cronise, Alysia, Denny, Vanessa, Mendez, Kylie, Newgen, Janine, Davis, Justin, Flory, Mike, Frantz, Robert, Murphy, Bryan, Rauch, Steve, Kim, Judy E., Bachman, Jane, Connor, Thomas B., Jr., Han, Dennis P., Stepian, Kimberly, Weinberg, David V., Wirostko, William J., Packard, Krissa, Kaczanowski, Tracy, Williams, Vesper, Barwick, Vicki, Flanders, Judy, Backes, Dennis, Beringer, Joe, Keller, Kristy, Selchert, Kathy, Bernstein, Paul, Teske, Michael, Vitale, Albert, Allman, Susan, Carlstrom, Bonnie, Wegner, Kimberley, Haroldsen, Anne, Harrison, Deborah, Fry, Cyrie, Gilman, James, Jenkins, Glen, Morris, Paula, Rauser, Michael, Fan, Joseph, Suthar, Mukesh, Santiago, Gisela, Halsey, Kara Rollins, Quesada, Christy, Kiernan, William, Knabb, Jesse, Lewis, Richard Alan, Dorenbach, Cindy, Spencer, Steven, Barnett, Dana, Morales, Joseph, Fishburne, Barron C., Gross, Jeffrey G., Magee, Michael A., Flowers, Amy, McDowell, Angie, Price, Randall, Huang, Suber, Tang, Johnny, Wilker, Shawn, Hornsby, Cherie, Ferguson, Lisa, Krogstad, Kirk, Adamovsky, Riva, Allchin, Peggy, Carlton, Kathleen, Clow, Claudia, Sholtis, Kelly, Burke, Stephanie, Harrod, Mark, Hrvatin, Stacie, Pankhurst, Geoffrey, Sabates, Nelson R., Cassell, Michael, Desai, Komal, Poulose, Abraham, Sabates, Felix, Chen, Yin, Gallimore, Gary, Konior, Yolanda, Kim, Nicola, Uwaydat, Sami, Troillett, Deborah, Aletter, Karen, Frank, Robert N., Abrams, Gary, Puklin, James, Tewari, Asheesh, Milanovic, Cheryl, Bailey, Melanie, Griffith, David, McDonald, Dena, Morehead, Kit, Sadikovic, Zlatan, Schillace, Lisa, Silvis, Elizabeth, Joondeph, Brian, Christmas, Nancy, Kimura, Alan, Liu, Mimi, Petty, Stephen, Zilis, John, Benitez, Jenny, Catlett, Cassandra Berryman, Fluegel, Eric, Mowry, Shane, Nguyen, Hoang, Reflow, David, Houghton, Odette M., Garg, Seema, Landers, Maurice B., Meredith, Travis, Barnhart, Sandy, Karmalkar, Megha, Cantrell, Debra, Esquejo-Leon, Rona Lyn, Manor, Linda, Pope, Sue, Stines, David, Stokely, Amelia, Hainsworth, Dean, Helming, Dyann, Eichelberger, Debbie, Leaton, Mary Paige, Hamm, Chuck, Chaum, Edward, Iannaccone, Alessandro, Jennings, Barbara, Murray, Tracy, Mastellone, Joe, Millay, Robert, Kim, Brian, Goddard, Theresa, Beaudette, Liza Jarrett, Changelian-Aitken, Nina, Corrada, Fernando, Dubuque, Jason, Iezzi, Raymond, Bakri, Sophie J., Pulido, Jose S., Vogen, Diane, Nielsen, Rebecca, Berg, Karin, Burrington, Jean, Howard, Shannon, Overend, Joan, Krason, Zbigniew, Lewison, Denise, Link, Thomas, Blinder, Kevin J., Engelbrecht, Nicholas E., Grand, M. Gilbert, Joseph, Daniel P., Shah, Gaurav K., Smith, Bradley, Thomas, Matthew, Weeks, Rhonda, Boyd, Lynda, Gabel, Dana, Adelman, Ron, Huang, John, Kempton, James, Parnes, Aaron, Dupont, Jennifer, Perotti, Elizabeth, Donaldson, Victoria, Fong, Kenneth, Ossorio, Pamela, Agarwal, Anita, Sternberg, Paul, Owings, Sandy, Adkins, Tony, Lok, Elaine, Munn, Garvin, Skellie, Buddy, Bhagat, Neelakshi, Roy, Monique S., Zarbin, Marco, Fay, Catherine, Lazar, Michael, Malpica, Beth, Mikheyav, Tatiana, Ulanski, Lawrence, II, Lim, Jennifer, Niec, Marcia, Johnson, Tametha, Ovando, Yesenia, Carroll, Catherine Nail, Janowicz, Mark, Schwartz, Steven, Cupp, David, Gorin, Michael, Heilweil, Gad, Hosseini, Hamid, Hubschman, Jean-Pierre, Kreiger, Allan, McCannel, Tara Young, Pan, Carolyn, Sarraf, David, Tsui, Irena, Udoetek, Joshua, Voleti, Vinad, Hitchcock, Logan, Ostrick, Rosaleen, Chun, Melissa, Kageyama, Jennie, Davila, Nilo, Lipka, Kristin, Shin, Christina, Owsley, Cynthia, Albert, Michael, Jr., Feist, Richard, Mason, John, Thomley, Martin, Johnson, Angelia, Emond, Tracy, Hamela, Joanna, Marsh, Angela, Searcey, Karen, Rookard, Kia, He, Yu-Guang, Ufret-Vincenty, Rafael L., Molai, Mike, Anderson, William, Horna, John, Letson, Alan, Cebulla, Colleen, Chang, Susie, Davidorf, Fred, Salerno, Jill, Sladoje, Laura, Stetson, Christina, Perry, Jeri, Savage, Scott, Toth, Cynthia, Jaffe, Glenn, Schuman, Stefanie, Sarin, Neeru, Crowell, Jim, Keaton, Tiffanie, Kelly, Michael, Lutman, Brian, Skelly, Marriner, Welch, Lauren, Morse, Lawrence, Hunter, Allan, Soon-Chun Park, Susanna, Wallace, Cynthia, Dhillon, Ember, Salvador, Marisa, Holderreed, Barbara, Chandra, Karishma, Kaur, Sashi, Redenbo, Ellen, Hom, Smiley, Cooney, Michael, Barbazetto, Irene, Klancnik, James M., Jr., Sorenson, John A., Yannuzzi, Lawrence, Scolaro, Maria, Agresta, Eugene, Gonzalez, Nancy, Grover, Sandeep, Chalam, K.V., Gupta, Shailesh, Lyons, Christopher, Li, Wenhua, Patel, Chirag, Carrion, Jose, Ferreyra, Henry, Rodriguez, Amberly, Molina, Iliana, Balea, Gabriel, Emory, Pam, Rico, Marlene, Siqueiros, Giorgio, Brucker, Alexander J., Dunaief, Joshua, Grunwald, Juan, Kim, Benjamin, Maguire, Albert M., VanderBeek, Brian, Drossner, Sheri, DuPont, Joan, Salvo, Rebecca, Berger, Jim, Devine, Cheryl, Nyberg, Bill, Weeney, Laurel, DiLoreto, David, Chung, Mina, Davis, Valerie, MacDowell, Peter, Gara, George O., Castillo, Daniel, Czubinski, Andrea, Keim, Melissa, Hardy, Brandi, Hollar, Rachel Grunhaus, Schueckler, Lynn, Lyon, Alice T., Weinberg, Aaron, Shiloach, Mira, Pelkofer, Nicole, Zhou, Qin, McPoland, Laura, Apte, Rajendra, Rao, P. Kumar, Pistorius, Sam, Kambarian, Jamie, Adcock, Eve, Gould, Sarah, Quinn, Melanie, Curtis, Rhonda, Frost, Amy, Meyer, Charla, Rathert, Greg, Yu, Jeannette J., Clemons, Traci E., van Asten, Freekje, and Keenan, Tiarnan D.

Published
2019
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17. Local Anatomic Precursors to New-Onset Geographic Atrophy in Age-Related Macular Degeneration as Defined on OCT

Author

Toth, Cynthia A., McCall, Michelle, Srivastava, Sunil, Winter, Katrina, Sarin, Neeru, Schuman, Stefanie, Chiu, Stephanie J., Farsiu, Sina, Tai, Vincent, Sevilla, Monica, Harrington, Christopher, Gunther, Randall, Tran-Viet, Du, Folgar, Francisco, Yuan, Eric, Wong, Wai, Hall, Katherine, Chew, Emily, Hwang, Thomas, McCollum, Patti, Hubbard, G. Baker, Curtis, Linda, Clemons, Traci, Harrington, Molly, Pasricha, Malini Veerappan, Sleiman, Karim, Stinnett, Sandra S., Lad, Eleonora M., Wong, Wai T., and Chew, Emily Y.

Published
2021
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20. Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16

Author

Chew, Emily Y., Ferris, Frederick L., III, SanGiovanni, John Paul, Agrón, Elvira, Clemons, Traci, Lindblad, Anne, Lindblad, Robert, Shah, Nilay, Sperduto, Robert, McBee, Wendy, Gensler, Gary, Harrington, Molly, Henning, Alice, Jones, Katrina, Thotapally, Kumar, Tull, Diana, Watson, Valerie, Williams, Kayla, Gentry, Christina, Kaufman, Francine, Morrison, Chris, Saverino, Elizabeth, Schenning, Sherrie, Blodi, Barbara, Danis, Ronald P., Davis, Matthew, Domalpally, Amitha, Glander, Kathy, Guilfoil, Gregory, Hubbard, Larry D., Johnson, Kristine, Klein, Ronald, Nardi, Barbara, Neider, Michael, Robinson, Nancy, Rosensteel, Eileen, Wabers, Hugh, Zhang, Grace, Ruby, Alan J., Capone, Antonio, Jr., Dass, Bawa, Drenser, Kimberly, Garretson, Bruce R., Hassan, Tarek S., Trese, Michael, Williams, George A., Wolfe, Jeremy, Bell, Tina, Zajechowski, Mary, Bezaire, Dennis, McIver, Fran, Medina, Anthony, Pagett, Jackie, Smith, Stephanie Hatch, Swartz, Lynn, Treuter, Tom, Antoszyk, Andrew, Brown, Justin, Browning, David J., Holland, Walter, Karow, Angella, Stalford, Kelly, Price, Angela, Ennis, Sarah, Fredenberg, Sherry, Herby, Jenna, Balasubramaniam, Uma, Clark, Loraine, McClain, Donna, McOwen, Michael, Watson, Lynn, Klein, Michael, Bailey, Steven T., Hwang, Thomas J., Lauer, Andreas, Stout, J. Timothy, McCollum, Patty, Johnson, Milt, Rice, Patrick B., Kim, Ivana, Loewenstein, John, Miller, Joan, Sobrin, Lucia, Young, Lucy, Sullivan, Jacqueline, Houlihan, Patricia, Merry, Linda, Lane, Ann Marie, Bator, Ursula Lord, Evans, Claudia, Brett, Sarah, Callahan, Charleen, Grillo, Marcia, Walsh, David, Zimmerman, Kamella Lau, Fish, Gary Edd, Anand, Rajiv, Coors, Lori E., Fuller, Dwain G., Spencer, Rand, Wang, Robert C., Duignan, Karen, Arceneaux, Sally, Aguado, Hank, Hesse, Nicholas, Mackens, Michael, Swan, Brian, Wong, Wai T., Cukras, Catherine, Dalal, Monica, Jacobs-El, Naima, Meyerle, Catherine, Nicholson, Benjamin, Wiley, Henry, Shimel, Katherine Hall, Garced, Angel, Oparah, Janice, Short, Greg, Temple, Alana, Ayukawa, Babilonia, Foster, Guy, Hayes, Darryl, Koutsandreas, Dessie, Nashwinter, Roula, Rowan, John, Bono, Michael, Cunningham, Denise, Palmer, Marilois, Zetina, Alicia, Orth, David H., Rezaei, Kourous, Civantos, Joseph, Hasan, Sohail, Packo, Kirk, Figliulo, Celeste, Stanberry, Pam, Farmer, Tara, Nelson, Kiersten, Townsend-Patrick, Shannya, Rosenfeld, Philip, Chen, Royce, Doshi, Rishi, Dubovy, Sander, Kim, Brian T., Lowrance, Matthew, Moshfeghi, Andrew, Nahas, Zayna, Schienbaum, Gary, Vishak, John, Weng, Christina, Yehoshua, Zohar, Rodriguez, Belen, Rebimbas, Jose, Gleichauf, Jane, Kicak, Mike, Mena, Jason, Odem, Tim, Sferza-Camp, Elizabeth, Disgdiertt, Alicia, Oramas, Jim, Rams, Isabel, Thatcher, Stephanie, Bressler, Susan B., Bressler, Neil M., Finkelstein, Daniel, Sherman, Steven H., Solomon, Sharon, Ying, Howard S., Denbow, Rita, Phillips, Deborah, Radcliffe, Elizabeth, Belt, Judy, Cain, Dennis, Emmert, David, Herring, Mark, McDonald, Jacquelyn, Hubbard, G. Baker, Bergstrom, Chris S., Cribbs, Blaine, Hendrick, Andrew, Johnson, Brandon, Laird, Philip, Mehta, Sonia, Olsen, Timothy, Townsend, Justin, Yan, Jion, Yeh, Steven, Curtis, Linda, Brower, Judy, Yi, Hannah, Dobbs, Jannah Rutter, Jordan, Debbie, Elman, Michael J., Liss, Robert A., Starr, JoAnn, Belz, Jennifer, Putzulo, Charlene, Coffey, Teresa, Davis, Ashley, Singletary, Pamela, Andreani, Giorya Shabi, Cain, Theresa, Ketner, Daniel, Sotirakos, Peter, Chandra, Suresh, Blodi, Barbara A., Altaweel, Michael M., Gottlieb, Justin L., Ip, Michael, Nork, T. Michael, Stevens, Thomas S., Burke, Kathryn, Olson, Shelly, Dietzman, Kristine, Soderling, Barbara, Somers, Guy, Wealti, Angie, Krolnik, Denise, Peterson, John, Reed, Sandra, Friberg, Thomas, Eller, Andrew, Gallagher, Denise, Labriola, Leanne, Pokrifka, Melissa, Gedansky, Aron, Anthony, Natalie, Grzybowski, Cassandra, Matthews, Dawn, Murajda-Jumba, Sharon, Toro, Jessica, Callanan, David G., Solley, Wayne A., Williams, Patrick, Lash, Sandy, Boleman, Bob, Dock, Chris, Shami, Michel, Arrington, Brenda, Meeks, Ashaki, Margherio, Alan R., Raphaelian, Paul, Markus, Debra, Langdon, Justin, Truax, Elizabeth, Lewis, Sandy, Terry, Brad, Noffke, Amy, Oh, Kean, Sarrafizadeh, Ramin, Sneed, Scott, Hammersley, Julie, Neal, Serena, Doran, Mary, Jones, Nan, Preston, Lisa, Jessick, Heather, Marsh, Tanya Tracy, Tolentino, Michael, Berger, Adam, Hamilton, Richard, Misch, David, Moon, Suk Jin, Sutherland, Dawn, Dilts, Vera, Henderson, Sara, Medina, Esmeralda, Trueman, Donald, Holm, Laura, Strickland, Jason, Ie, Darmakusuma, Lipkowitz, Jeffrey L., Shah, Kekul B., Geraghty, Susan, Sannazzaro, Beverly, Harper, Morgan, Bayer, Krista, Lansing, Mary B., Fox, Lauren B., Lee, Rebecca, Stallman, Jay B., Jacobson, Michael, Koh, Sean, Lampert, Scott, Miller, John, Rivellese, Mark, Sharma, Atul, Stoltz, Robert A., Vanderveldt, Stephanie, Marcus, Leslie, Hendricks, Starr, Hollman, Ryan, Betanzos, Grethel, Ellorin, Leslie, Fulbright, Shelly, McCormick, Debbie, Edwards, Paul A., Hall, Julianne, Monk, Mary, Gutkowski, Melanie, Mazurek, Melina, Murphy, Janet, Gusas, Katherine, Moffett, Crystal, Burley, David, Chesney, Nicole, Kilgo, Katie, Rusinek, Brian, Stern, Bradley, Troszak, Tracy, Baker-Levingston, Rhonda, Baker, Carl W., Caldwell, Tracey, Walker, Tammy, Lambert, Lynnette F., Martin, Tracey, Palmer, Mary Jill, Williams, Tana, Novak, Michael A., Coney, Joseph, Miller, David G., Pendergast, Scott, Singerman, Lawrence, Zakov, Nicholas, Zegarra, Hernando, DuBois, Kim, Rath, Susan, Revella, Lori, Brink, Tammy, Drury, Kim, Hogue, Lisa, Ilc, Mary, Keller, Connie, McNamara, Elizabeth, Tanner, Vivian, Cunningham, Tamara, DuBois, John, Greanoff, Gregg, Nitzsche, Trina, Smith-Brewer, Sheila, Isernhagen, Ricky D., Kitchens, John W., Stone, Thomas W., Wood, William J., Holcomb, Diana, Therrien, Virginia, Buck, Michelle, Van Arsdall, Jeanne, Slade, Edward, Schneiderman, Todd E., Spinak, David J., Gaedke, Jackie, Brown, Heather Davis, Helgren, Dan, Pangelinan, Jenifer Garrison, Halperin, Lawrence, Anagnoste, Scott, Dhalla, Mandeep, Rosenberg, Krista, Taney, Barry, Thompson, W. Scott, Lopez, Jaclyn, Hamlin, Monica, Lopez, Monica, Mariano, Jamie, Quinchia, Evelyn, Aramayo, Patricia, Veksler, Rita, Lee, Michael, Dreyer, Richard, Handelman, Irvin, Ma, Colin, Peters, Mark, Hobbs, Stephen, III, Milliron, Amanda, Kopfer, Marcia, Connaughton, Michele, Hoerner, A. Christine, Logan, R. Joseph, Wohlsein, Harry J., Boyer, David, Chu, Thomas G., Dayani, Pouya, Liao, David, Novack, Roger L., Rahhal, Firas M., Roe, Richard, Tabandeh, Homayoun, Bayramyan, Janet, Gasparyan, Tammy, Hoang, Connie, Kurokouchi, Janet, Lo, Tammy Eileen, Ngo, Richard, Nguyen, Mary Ann, Peyton, Michael, Yoon, Charles, Sierra, Julio, Zamboni, Adam, Kessinger, Jeff, Protacio, Eric, Smucker, Adam, Rath, Pamela, Bergren, Robert, Doft, Bernard, Liu, Judy, Olsen, Karl, Merlotti, Lori, Ingram, Willia, Marfisi, Kellianne, Yeckel, Kimberly, Carmelo, Heather Schultz, Fec, Amanda, McBroom, Keith, Steinberg, David, Levy, Marc, Abrams, Jody, Chen, Melvin, Torres, Waldemar, Jelemensky, Peggy, Prybylski, Mark, Raphael, Tara, Appleby, Diana, Rodman, Charlotte, Sneath, Mark, Rosa, Robert H., Jr., Hoelscher, Vanessa, Castano, Adelia, Parker, Jocelyn, Hoskins, John, Anderson, Nicholas, Googe, Joseph, Jr., McMillan, Tod A., Miller, James, Jr., Perkins, Stephen, Oliver, Kristina, Beerbower, Jennifer, Gilliland, Bruce, Hunt, Cecile, Jacobus, Mike, Lince, Raul, Morris, Christopher, Oelrich, Sarah, Whetstone, Jerry, Chan, Clement K., Lin, Steven, Walther, Kim, Gonzales, Tiana, Myers, Lenise, Huff, Kenneth, Brown, David M., Chen, Eric, Benz, Matthew S., Fish, Richard H., Kim, Rosa Y., Major, James, Jr., Wong, Tien Pei, Wycoff, Charles, Cone, Cassandra, Gilaspia, Debbie Goates, Landaverde, Nubia, Smith, Robert, Zamora, Deneva, Sneed, Veronica, Vela, Melina, Kegley, Eric, Greven, Craig, Kurup, Shree, Richards, Charles, Slusher, Madison, Everhart, Cara, Fish, Joan, Clark, Mark, Miller, David, Tyler, Marshall, Jumper, J. Michael, Fu, Arthur D., Johnson, Robert N., Lujan, Brandon, McDonald, H. Richard, Rodriguez, Rosa, Ansari, Nina, Joaquin, Jeanifer, Linares, Silvia, Lopez, Lizette, Sabio, Jessica, Grout, Sean, Indermill, Chad, Urias, Yesmin, Zimmerman, Roberto, Margulies, Linda, Schmidt, Sara J., Meier, Joy L., Hadley, Sherry L., Rosenthal, William, Johnson, Barbara, Swafford, Lois, Shields, Richard, Varner, R. Scott, Rosen, Richard, Gentile, Ronald, Rivas, Melissa, Tai, Katy W., Carrasquillo-Boyd, Wanda, Masini, Robert, Stoller, Glenn, Carnevale, Ken, LaRosa, Diane M., Burger, Barbara, Conway, Tereza, Del Castillo, Carla, Diaz, Julissa, Jones, Susan, Mondoc, Nina, Balfour, Charlene, Vitha, C.H., Lutz, Jennifer, McGinley, Barbara, El Baba, Fadi, Lavorna, Ann Marie, Jones, Renee, Lewis, Jean, Tenzler, Ruth, Salvas-Mladek, Mary, Van Kesteren, Diane, McLean, W. Copley, Jr., Bridges, W. Zachery, Jr., Stone, Cameron, Ammons, Denise, Lamy, Mary, Menzel, Andrea, Raymer, Lea Doll, Campbell, Barbara, Hawkins, Lisa, Rickman, Leslie, Sherlin, Lorraine, Price, Paula, Sinyai, Albert, Kingsley, Ronald, Bradford, Reagan H., Jr., Leonard, Robert E., II, Icks, Sonny, Bergman, Vanessa, Ross, Brittany, Burris, Russ, Butt, Amanda, Richmond, Rob, Lyon, Alice, Gill, Manjot, Jampol, Lee, Mizra, Rukhsana, Rozenbajgier, Zuzanna, Chapman, Jeremy, Kaminski, Lori, Degillio, Andrea, Simjanoski, Evica, Heier, Jeffrey, Cho, Hyung, Cleary, Tina Scheufele, Goldman, Darin, Shah, Chirag, Topping, Trexler, Weber, Marissa, Wiegand, Torsten, Schindelheim, Jeremy, Bankert, Joy, Stone, Jennifer, Nowak, Alison, Chong, Sandy, Williams, Lindsay, Bennett, Steven, Donovan, Dennis, Graham, Margaret, Jones, Cullen, Fung, Anne, Bayabo, Jan-Kristine, Bosch, Razelda, Cruz, Esperanza, Emerson, Ashley, Fleming, Alycia, Barsness, Denice, Rodriguez, Jorge, Soboleva, Marina, Scott, Ingrid U., Bowie, Esther, Neely, Kimberly A., Quillen, David A., Walter, Laura, Bennett, Timothy, Strong, James, Wells, John, III, Clark, Lloyd, Johnson, David, Miller, Peggy, Taylor, Mallie, Swinford, Tiffany, Spivey, Robbin, Banach, Michael, Ho, Lawrence, Lanning, Richard, Pheasant, Thomas R., Prensky, Jay G., Truong, Steven, Teatsworth, Julia, Dietrich, Michelle, Wasilus, Ann, Miller, Ann, Rakes, Megan, Slagle, Teresa, Richards, Michelle, Schuessler, Patricia, Stover, Lacy, Beer, Paul, Falk, Naomi S., Shannon, Mary Beth, Olmeda, Jeannie, Berdeen, Don, Fisher, Joseph F., Jr., Folk, James, Russell, Stephen, Taylor, Barbara, Hinz, Connie, Walshire, Jean, Stockman, Heather, Critser, Bruce, Karakas, Stefani, Montague, Cindy, Verdick, Randy, Gupta, Omesh, Maguire, Joseph, Brady, Christopher, DeCroos, Francis Char, Dollin, Michael, Garg, Sunir, Gerstenblith, Adam, Haller, Julia, Ho, Allen C., Hsu, Jason, Kaiser, Richard, Pitcher, John, Regillo, Carl, Shah, Rajiv, Spirn, Marc, Tasman, William, Vander, James, Senderowitsch, Noga, Formoso, Michele, Markun, Michelle, George, Cedric, Centinaro, Christina, Grande, Lisa, Carey, Stefanie, Liebenbaum, Elaine, Sadda, SriniVas, Humayun, Mark, Sierra, Rachel, Corona, Elizabeth, Padilla, Margaret, Nu, Moonseok, Ramos, Sylvia, Barnett, Cullen, Currie, Glenn, Gottlieb, Cornelia, Garfinkel, Richard, Berinstein, Daniel, Colyer, Marcus, Deegan, William, III, Min-Shyue Lai, Michael, Murphy, Robert, Osman, Michael, Rivers, Michael, Sanders, Reginald, von Fricken, Manfred A., Oliver, Debbie, Kirshon, Jeanne, Snowden, Tanya Alexander, Blondo, Thomas, Cronise, Alysia, Denny, Vanessa, Mendez, Kylie, Newgen, Janine, Davis, Justin, Flory, Mike, Frantz, Robert, Murphy, Bryan, Rauch, Steve, Kim, Judy E., Bachman, Jane, Connor, Thomas B., Jr., Han, Dennis P., Stepian, Kimberly, Weinberg, David V., Wirostko, William J., Packard, Krissa, Kaczanowski, Tracy, Williams, Vesper, Barwick, Vicki, Flanders, Judy, Backes, Dennis, Beringer, Joe, Keller, Kristy, Selchert, Kathy, Bernstein, Paul, Teske, Michael, Vitale, Albert, Allman, Susan, Carlstrom, Bonnie, Wegner, Kimberley, Haroldsen, Anne, Harrison, Deborah, Fry, Cyrie, Gilman, James, Jenkins, Glen, Morris, Paula, Rauser, Michael, Fan, Joseph, Suthar, Mukesh, Santiago, Gisela, Halsey, Kara Rollins, Quesada, Christy, Kiernan, William, Knabb, Jesse, Lewis, Richard Alan, Dorenbach, Cindy, Spencer, Steven, Barnett, Dana, Morales, Joseph, Fishburne, Barron C., Gross, Jeffrey G., Magee, Michael A., Flowers, Amy, McDowell, Angie, Price, Randall, Huang, Suber, Tang, Johnny, Wilker, Shawn, Hornsby, Cherie, Ferguson, Lisa, Krogstad, Kirk, Adamovsky, Riva, Allchin, Peggy, Carlton, Kathleen, Clow, Claudia, Sholtis, Kelly, Burke, Stephanie, Harrod, Mark, Hrvatin, Stacie, Pankhurst, Geoffrey, Sabates, Nelson R., Cassell, Michael, Desai, Komal, Poulose, Abraham, Sabates, Felix, Chen, Yin, Gallimore, Gary, Konior, Yolanda, Kim, Nicola, Uwaydat, Sami, Troillett, Deborah, Aletter, Karen, Frank, Robert N., Abrams, Gary, Puklin, James, Tewari, Asheesh, Milanovic, Cheryl, Bailey, Melanie, Griffith, David, McDonald, Dena, Morehead, Kit, Sadikovic, Zlatan, Schillace, Lisa, Silvis, Elizabeth, Joondeph, Brian, Christmas, Nancy, Kimura, Alan, Liu, Mimi, Petty, Stephen, Zilis, John, Benitez, Jenny, Catlett, Cassandra Berryman, Fluegel, Eric, Mowry, Shane, Nguyen, Hoang, Reflow, David, Houghton, Odette M., Garg, Seema, Landers, Maurice B., Meredith, Travis, Barnhart, Sandy, Karmalkar, Megha, Cantrell, Debra, Esquejo-Leon, Rona Lyn, Manor, Linda, Pope, Sue, Stines, David, Stokely, Amelia, Hainsworth, Dean, Helming, Dyann, Eichelberger, Debbie, Leaton, Mary Paige, Hamm, Chuck, Chaum, Edward, Iannaccone, Alessandro, Jennings, Barbara, Murray, Tracy, Mastellone, Joe, Millay, Robert, Kim, Brian, Goddard, Theresa, Beaudette, Liza Jarrett, Changelian-Aitken, Nina, Corrada, Fernando, Dubuque, Jason, Iezzi, Raymond, Bakri, Sophie J., Pulido, Jose S., Vogen, Diane, Nielsen, Rebecca, Berg, Karin, Burrington, Jean, Howard, Shannon, Overend, Joan, Krason, Zbigniew, Lewison, Denise, Link, Thomas, Blinder, Kevin J., Engelbrecht, Nicholas E., Grand, M. Gilbert, Joseph, Daniel P., Shah, Gaurav K., Smith, Bradley, Thomas, Matthew, Weeks, Rhonda, Boyd, Lynda, Gabel, Dana, Adelman, Ron, Huang, John, Kempton, James, Parnes, Aaron, Dupont, Jennifer, Perotti, Elizabeth, Donaldson, Victoria, Fong, Kenneth, Ossorio, Pamela, Agarwal, Anita, Sternberg, Paul, Owings, Sandy, Adkins, Tony, Lok, Elaine, Munn, Garvin, Skellie, Buddy, Bhagat, Neelakshi, Roy, Monique S., Zarbin, Marco, Fay, Catherine, Lazar, Michael, Malpica, Beth, Mikheyav, Tatiana, Ulanski, Lawrence, II, Lim, Jennifer, Niec, Marcia, Johnson, Tametha, Ovando, Yesenia, Carroll, Catherine Nail, Janowicz, Mark, Schwartz, Steven, Cupp, David, Gorin, Michael, Heilweil, Gad, Hosseini, Hamid, Hubschman, Jean-Pierre, Kreiger, Allan, McCannel, Tara Young, Pan, Carolyn, Sarraf, David, Tsui, Irena, Udoetek, Joshua, Voleti, Vinad, Hitchcock, Logan, Ostrick, Rosaleen, Chun, Melissa, Kageyama, Jennie, Davila, Nilo, Lipka, Kristin, Shin, Christina, Owsley, Cynthia, Albert, Michael, Jr., Feist, Richard, Mason, John, Thomley, Martin, Johnson, Angelia, Emond, Tracy, Hamela, Joanna, Marsh, Angela, Searcey, Karen, Rookard, Kia, He, Yu-Guang, Ufret-Vincenty, Rafael L., Molai, Mike, Anderson, William, Horna, John, Letson, Alan, Cebulla, Colleen, Chang, Susie, Davidorf, Fred, Salerno, Jill, Sladoje, Laura, Stetson, Christina, Perry, Jeri, Savage, Scott, Toth, Cynthia, Jaffe, Glenn, Schuman, Stefanie, Sarin, Neeru, Crowell, Jim, Keaton, Tiffanie, Kelly, Michael, Lutman, Brian, Skelly, Marriner, Welch, Lauren, Morse, Lawrence, Hunter, Allan, Soon-Chun Park, Susanna, Wallace, Cynthia, Dhillon, Ember, Salvador, Marisa, Holderreed, Barbara, Chandra, Karishma, Kaur, Sashi, Redenbo, Ellen, Hom, Smiley, Cooney, Michael, Barbazetto, Irene, Klancnik, James M., Jr., Sorenson, John A., Yannuzzi, Lawrence, Scolaro, Maria, Agresta, Eugene, Gonzalez, Nancy, Grover, Sandeep, Chalam, K.V., Gupta, Shailesh, Lyons, Christopher, Li, Wenhua, Patel, Chirag, Carrion, Jose, Ferreyra, Henry, Rodriguez, Amberly, Molina, Iliana, Balea, Gabriel, Emory, Pam, Rico, Marlene, Siqueiros, Giorgio, Brucker, Alexander J., Dunaief, Joshua, Grunwald, Juan, Kim, Benjamin, Maguire, Albert M., VanderBeek, Brian, Drossner, Sheri, DuPont, Joan, Salvo, Rebecca, Berger, Jim, Devine, Cheryl, Nyberg, Bill, Weeney, Laurel, DiLoreto, David, Chung, Mina, Davis, Valerie, MacDowell, Peter, Gara, George O., Castillo, Daniel, Czubinski, Andrea, Keim, Melissa, Hardy, Brandi, Hollar, Rachel Grunhaus, Schueckler, Lynn, Lyon, Alice T., Weinberg, Aaron, Shiloach, Mira, Pelkofer, Nicole, Zhou, Qin, McPoland, Laura, Apte, Rajendra, Rao, P. Kumar, Pistorius, Sam, Kambarian, Jamie, Adcock, Eve, Gould, Sarah, Quinn, Melanie, Curtis, Rhonda, Frost, Amy, Meyer, Charla, Rathert, Greg, Keenan, Tiarnan D., Clemons, Traci E., van Asten, Freekje, Danis, Ronald G., Rosenfeld, Philip J., Klein, Michael L., Ratnapriya, Rinki, and Swaroop, Anand

Published
2018
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26. Changes in Lens Opacities on the Age-Related Eye Disease Study Grading Scale Predict Progression to Cataract Surgery and Vision Loss Age-Related Eye Disease Study Report No. 34

Author

Indaram, Maanasa, Agrón, Elvira, Clemons, Traci E, Sperduto, Robert D, Wong, Wai T, Ferris, Frederick L, Chew, Emily Y, and Group, Age-Related Eye Disease Study Research

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Aging, Clinical Trials and Supportive Activities, Clinical Research, Eye Disease and Disorders of Vision, Eye, Aged, Aged, 80 and over, Blindness, Cataract, Cataract Extraction, Cohort Studies, Disease Progression, Female, Follow-Up Studies, Humans, Macular Degeneration, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Severity of Illness Index, Visual Acuity, Age-Related Eye Disease Study Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

PURPOSE:To investigate whether the 2-year change in lens opacity severity on the Age-Related Eye Disease Study (AREDS) lens grading scale predicts progression to cataract surgery or loss of visual acuity by 5 years. DESIGN:Prospective cohort study within a randomized clinical trial of oral supplements. PARTICIPANTS:The AREDS participants whose eyes were phakic at baseline and free of late age-related macular degeneration throughout the study. METHODS:Baseline and annual lens photographs of AREDS participants (n = 3466/4757; 73%) were graded for severity of cataracts using the AREDS system for classifying cataracts from photographs. Clinical examinations conducted semiannually collected data on cataract surgery and visual acuity. Association of the change in lens opacities at 2 years with these outcomes at 5 years was analyzed with adjusted Cox proportional hazard models. MAIN OUTCOME MEASUREMENTS:Progression of lens opacities on stereoscopic lens photographs at 2 years, cataract surgery, and visual acuity loss of 2 lines or more at 5 years. RESULTS:The adjusted hazard ratios (HRs) for association of progression to cataract surgery at 5 years were: nuclear cataract increase of 1.0 unit or more compared with less than 1.0-unit change at 2 years, 2.77 (95% confidence interval [CI], 2.07-3.70; P < 0.001); cortical cataract increase of 5% or more in lens opacity in the central 5 mm of the lens compared with less than 5% increase at 2 years, 1.91 (95% CI, 1.27-2.87; P = 0.002); and posterior subcapsular cataract increase of 5% or more versus less than 5% in the central 5 mm of the lens, 8.25 (95% CI, 5.55-12.29; P < 0.001). Similarly, HRs of vision loss of 2 lines or more at 5 years for this degree of lens changes at 2 years were the following: nuclear, 1.83 (95% CI, 1.49-2.25; P < 0.001); cortical, 1.13 (95% CI, 0.78-1.65; P = 0.519); and posterior subcapsular cataract, 3.05 (95% CI, 1.79-5.19; P < 0.001). CONCLUSIONS:Two-year changes in severity of lens opacities on the AREDS lens grading scale are predictive of long-term clinically relevant outcomes, making them potential surrogate end points in follow-up studies.

Published
2015

37. Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures

Author

Benjamin, Daniel K., Jr, Berezny, Katherine Y., Wolkowiez, P. Michael Cohen, Laughon, Matthew M., Paul, Ian M., Smith, Michael J., van den Anker, John, Wade, Kelly, Siegel, David, Taylor-Zapata, Perdita, Zajicek, Anne, Ren, Zhaoxia, Tsilou, Ekaterini, Pagan, Alice, Anand, Ravinder, Clemons, Traci, Simone, Gina, Howard, Lee, Weigel, Jaylene, Darden Saad, Nancy, Shakhnovich, Valentina, Smith, P. Brian, Guptill, Jeffrey T., James, Laura P., Collier, David N., Wu, Huali, Livingston, Chad E., Zhao, Jian, and Kearns, Gregory L.

Published
2018
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38. Change in Area of Geographic Atrophy in the Age-Related Eye Disease Study: AREDS Report Number 26

Author

Lindblad, Anne S, Lloyd, Patricia C, Clemons, Traci E, Gensler, Gary R, Ferris, Frederick L, Klein, Michael L, and Armstrong, Jane R

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Neurodegenerative, Clinical Research, Eye Disease and Disorders of Vision, Macular Degeneration, Eye, Aged, Aged, 80 and over, Antioxidants, Atrophy, Choroidal Neovascularization, Copper, Disease Progression, Female, Humans, Male, Middle Aged, Photography, Prospective Studies, Retinal Pigment Epithelium, Vision Disorders, Visual Acuity, Zinc Oxide, Age-Related Eye Disease Study Research Group, Opthalmology and Optometry, Ophthalmology & Optometry
Abstract

ObjectiveTo characterize progression of geographic atrophy (GA) associated with age-related macular degeneration in AREDS as measured by digitized fundus photographs.MethodsFundus photographs from 181 of 4757 AREDS participants with a GA area of at least 0.5 disc areas at baseline or from participants who developed bilateral GA during follow-up were scanned, digitized, and evaluated longitudinally. Geographic atrophy area was determined using planimetry. Rates of progression from noncentral to central GA and of vision loss following development of central GA included the entire AREDS cohort.ResultsMedian initial lesion size was 4.3 mm(2). Average change in digital area of GA from baseline was 2.03 mm(2) (standard error of the mean, 0.24 mm(2)) at 1 year, 3.78 mm(2) (0.24 mm(2)) at 2 years, 5.93 mm(2) (0.34 mm(2)) at 3 years, and 1.78 mm(2) (0.086 mm(2)) per year overall. Median time to developing central GA after any GA diagnosis was 2.5 years (95% confidence interval, 2.0-3.0). Average visual acuity decreased by 3.7 letters at first documentation of central GA, and by 22 letters at year 5.ConclusionsGrowth of GA area can be reliably measured using standard fundus photographs that are digitized and subsequently graded at a reading center. Development of GA is associated with subsequent further growth of GA, development of central GA, and loss in central vision.

Published
2009

39. Optical Coherence Tomography Predictors of Risk for Progression to Non-Neovascular Atrophic Age-Related Macular Degeneration

Author

Toth, Cynthia A., Wong, Wai, Huang, Thomas, Hubbard, G. Baker, Srivastava, Sunil, McCall, Michelle, Winter, Katrina, Sarin, Neeru, Hall, Katherine, McCollum, Patti, Curtis, Linda, Schuman, Stefanie, Chiu, Stephanie J., Farsiu, Sina, Tai, Vincent, Clemons, Traci, Chew, Emily, Sleiman, Karim, Veerappan, Malini, Winter, Katrina P., McCall, Michelle N., Yiu, Glenn, and Chew, Emily Y.

Published
2017
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42. Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration

Author

Toth, Cynthia A., Wong, Wai, Hwang, Thomas, Hubbard, G. Baker, Srivastava, Sunil, McCall, Michelle, Winter, Katrina, Sarin, Neeru, Hall, Katherine, McCollum, Patti, Curtis, Linda, Schuman, Stefanie, Chiu, Stephanie J., Farsiu, Sina, Tai, Vincent, Sevilla, Monica, Harrington, Christopher, Gunther, Randall, Tran-Viet, Du, Folgar, Francisco, Yuan, Eric, Clemons, Traci, Harrington, Molly, Chew, Emily, Veerappan, Malini, El-Hage-Sleiman, Abdul-Karim M., Winter, Katrina P., Stinnett, Sandra S., Hwang, Thomas S., Hubbard, G. Baker, III, Michelson, Michelle, Wong, Wai T., and Chew, Emily Y.

Published
2016
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47. Population Pharmacokinetics and Exploratory Pharmacodynamics of Lorazepam in Pediatric Status Epilepticus

Author

Gonzalez, Daniel, Chamberlain, James M., Guptill, Jeffrey T., Cohen-Wolkowiez, Michael, Harper, Barrie, Zhao, Jian, Capparelli, Edmund V., Benjamin, Daniel K., Berezny, Katherine Y., Kearns, Gregory L., Laughon, Matthew M., Paul, Ian M., Smith, Michael J., Smith, P. Brian, van den Anker, John, Wade, Kelly, Siegel, David, Taylor-Zapata, Perdita, Zajicek, Anne, Ren, Zhaoxia, Tsilou, Ekaterini, Pagan, Alice, Anand, Ravinder, Clemons, Traci, Simone, Gina, Cohen-Wolkowiez, Michael, Watt, Kevin, Guptill, Jeffrey T., Harper, Barrie, Gonzalez, Daniel, Capparelli, Edmund V., and On behalf of the Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee

Published
2017
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