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3. Rapid generation of potent antibodies by autonomous hypermutation in yeast

Author

Wellner, Alon, McMahon, Conor, Gilman, Morgan SA, Clements, Jonathan R, Clark, Sarah, Nguyen, Kianna M, Ho, Ming H, Hu, Vincent J, Shin, Jung-Eun, Feldman, Jared, Hauser, Blake M, Caradonna, Timothy M, Wingler, Laura M, Schmidt, Aaron G, Marks, Debora S, Abraham, Jonathan, Kruse, Andrew C, and Liu, Chang C

Subjects
Prevention, Biotechnology, Vaccine Related, Immunization, Generic health relevance, Antibodies, Antibody Formation, Antigens, COVID-19, Humans, Peptide Library, Protein Engineering, Recombinant Proteins, SARS-CoV-2, Saccharomyces cerevisiae, Single-Domain Antibodies, Spike Glycoprotein, Coronavirus, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Biochemistry & Molecular Biology
Abstract

The predominant approach for antibody generation remains animal immunization, which can yield exceptionally selective and potent antibody clones owing to the powerful evolutionary process of somatic hypermutation. However, animal immunization is inherently slow, not always accessible and poorly compatible with many antigens. Here, we describe 'autonomous hypermutation yeast surface display' (AHEAD), a synthetic recombinant antibody generation technology that imitates somatic hypermutation inside engineered yeast. By encoding antibody fragments on an error-prone orthogonal DNA replication system, surface-displayed antibody repertoires continuously mutate through simple cycles of yeast culturing and enrichment for antigen binding to produce high-affinity clones in as little as two weeks. We applied AHEAD to generate potent nanobodies against the SARS-CoV-2 S glycoprotein, a G-protein-coupled receptor and other targets, offering a template for streamlined antibody generation at large.

Published
2021

4. Living was easy. Dying is harder

Author

Clements, Jonathan

Subjects
Terminally ill persons -- Social aspects, Death -- Social aspects, General interest, News, opinion and commentary
Abstract

Byline: Jonathan Clements What if you were told you had a year to live? Life coaches sometimes pose questions like this to help folks figure out what's truly important to [...]

Published
2024

10. List of Contributors

Author

Aladedunye, Felix, primary, Apea-Bah, Franklin B., additional, Awika, Joseph M., additional, Clements, Jonathan, additional, Coorey, Ranil, additional, D’Amico, Stefano, additional, Dalton, Timothy J., additional, Duodu, Kwaku G., additional, Johnson, Stuart K., additional, Klensporf-Pawlik, Dorota, additional, Langó, Bernadett, additional, Schoenlechner, Regine, additional, Tömösközi, Sándor, additional, Taylor, John R.N., additional, and Villarino, Casiana Blanca J., additional

Published
2017
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31. Rapid generation of potent antibodies by autonomous hypermutation in yeast

Author

Wellner, Alon, primary, McMahon, Conor, additional, Gilman, Morgan S. A., additional, Clements, Jonathan R., additional, Clark, Sarah, additional, Nguyen, Kianna M., additional, Ho, Ming H., additional, Shin, Jung-Eun, additional, Feldman, Jared, additional, Hauser, Blake M., additional, Caradonna, Timothy M., additional, Wingler, Laura M., additional, Schmidt, Aaron G., additional, Marks, Debora S., additional, Abraham, Jonathan, additional, Kruse, Andrew C., additional, and Liu, Chang C., additional

Published
2020
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33. 28 June : Sarajevo 1914 - Versailles 1919: The War and Peace That Made the Modern World

Author

Sharp, Alan, Edited by, Sharp, Alan, Djokic, Dejan, Alston, Charlotte, Braschi, Edoardo, Cartledge, Bryan, Clements, Jonathan, Dalby, Andrew, de Meneses, Filipe Ribeiro, Di Scala, Spencer, Fattacciu, Irene, Fraser, TG, Green, Stephen, Hitchins, Keith, Hudson, Mariella, Lentin, Antony, Mango, Andrew, Marks, Sally, McNamara, Robert, Prazmowska, Anita, Watson, David Robin, Sharp, Alan, Sharp, Alan, Djokic, Dejan, Alston, Charlotte, Braschi, Edoardo, Cartledge, Bryan, Clements, Jonathan, Dalby, Andrew, de Meneses, Filipe Ribeiro, Di Scala, Spencer, Fattacciu, Irene, Fraser, TG, Green, Stephen, Hitchins, Keith, Hudson, Mariella, Lentin, Antony, Mango, Andrew, Marks, Sally, McNamara, Robert, Prazmowska, Anita, and Watson, David Robin

Published
2014

35. Some Final Personal-Finance Advice From Jonathan Clements.

Author

Clements, Jonathan

Subjects
*PERSONAL finance, *INHERITANCE & transfer tax, *INDIVIDUAL retirement accounts, *FINANCIAL policy, *SOCIAL security
Abstract

Jonathan Clements, a former Wall Street Journal columnist, is facing a terminal cancer diagnosis and is focusing on organizing his estate and ensuring his family's financial stability. He has been having numerous conversations with his family about his estate, simplifying his finances, and making necessary changes to his will and beneficiary designations. Clements emphasizes the importance of financial flexibility and resilience, and is also making financial gifts to his children within the gift-tax exclusion limit. Additionally, he is forgiving a private mortgage to ease the settlement of his affairs and considering the tax implications of his financial decisions for his family's benefit. [Extracted from the article]

Published
2024

43. The legume NOOT-BOP-COCH-LIKE genes are conserved regulators of abscission, a major agronomical trait in cultivated crops

Author

Couzigou, Jean-Malo, Magne, Kevin, Mondy, Samuel, Cosson, Viviane, Clements, Jonathan, Ratet, Pascal, Interactions Microbiennes dans la Rhizosphère et les Racines, Laboratoire de Recherche en Sciences Végétales (LRSV), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut des sciences du végétal (ISV), Centre National de la Recherche Scientifique (CNRS), CNRS, grant ANR Blanc International SVSE from the Agence National de la Recherche [6.2010.1], French Ministry of Research, French Academy of Agriculture, Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Crops, Agricultural, [SDV]Life Sciences [q-bio], fungi, Arabidopsis, Peas, food and beverages, Fabaceae, Lupinus, abscission, Gene Expression Regulation, Plant, Multigene Family, Lotus japonicus, Brassicaceae, Mutation, Medicago truncatula, Lotus, Cluster Analysis, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Plant Proteins
Abstract

International audience; Plants are able to lose organs selectively through a process called abscission. This process relies on the differentiation of specialized territories at the junction between organs and the plant body that are called abscission zones (AZ). Several genes control the formation or functioning of these AZ. We have characterized BLADE-ON-PETIOLE (BOP) orthologues from several legume plants and studied their roles in the abscission process using a mutant approach. Here, we show that the Medicago truncatula NODULE ROOT (NOOT), the Pisum sativum COCHLEATA (COCH) and their orthologue in Lotus japonicus are strictly necessary for the abscission of not only petals, but also leaflets, leaves and fruits. We also showed that the expression pattern of the M. truncatula pNOOT::GUS fusion is associated with functional and vestigial AZs when expressed in Arabidopsis. In addition, we show that the stip mutant from Lupinus angustifolius, defective in stipule formation and leaf abscission, is mutated in a BOP orthologue. In conclusion, this study shows that this clade of proteins plays an important conserved role in promoting abscission of all aerial organs studied so far.

Published
2016
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44. A Brief History of the Samurai

Author

Clements, Jonathan and Clements, Jonathan

Subjects
Samurai--Japan--History
Abstract

From a leading expert in Japanese history, this is one of the first full histories of the art and culture of the Samurai warrior. The Samurai emerged as a warrior caste in Medieval Japan and would have a powerful influence on the history and culture

Published
2013

45. A Brief History of the Vikings

Author

Clements, Jonathan and Clements, Jonathan

Subjects
Vikings
Abstract

'From the Fury of the Northmen deliver us, O Lord.'Between the eighth and eleventh centuries, the Vikings surged from their Scandinavian homeland to trade, raid and invade along the coasts of Europe. Their influence and expeditions extended from Newfoundland to Baghdad, their battles were as far-flung as Africa and the Arctic. But were they great seafarers or desperate outcasts, noble heathens or oafish pirates, the last pagans or the first of the modern Europeans? This concise study puts medieval chronicles, Norse sagas and Muslim accounts alongside more recent research into r.

Published
2013

46. Additional file 3: of Application of whole genome re-sequencing data in the development of diagnostic DNA markers tightly linked to a disease-resistance locus for marker-assisted selection in lupin (Lupinus angustifolius)

Author

Huaan Yang, Jianbo Jian, Li, Xuan, Renshaw, Daniel, Clements, Jonathan, Sweetingham, Mark, Tan, Cong, and Chengdao Li

Abstract

Discovery of SNP markers and InDel markers, and identification of diagnostic markers for the R gene PhtjR conferring PSB disease resistance by marker mining on scaffold87443 in the genome sequence assembly of Lupinus angustifolius. (DOCX 171 kb)

Published
2015
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47. Insurance

Author

Clements, Jonathan

Subjects
Forbes (Periodical) -- Directories, Insurance industry -- Directories, Business rankings -- Statistics, GEICO Corp. -- Finance
Published
1990

48. The Art of War : A New Translation

Author

Sunzi, Clements, Jonathan, Sunzi, and Clements, Jonathan

Subjects
Military art and science--China--Early works to 1800
Abstract

A new translation for the 21st century. The Art of War by Sun Tzu is one of the most influential political and business books of our era. This gateway edition for the 21st century reader rediscovers the essential clarity of the ancient masterpiece, cited by generals from a dozen Chinese dynasties, international business leaders, and modern military field manuals. This edition also contains a full commentary on Sun Tzu, the man and his ideas, contemporary of Confucius and Buddha; and a critical guide to further reading. This is the perfect introduction to one of the world's best-known classic.

Published
2012

49. One man's problem is another's opportunity.

Author

Saunders, Laura and Clements, Jonathan

Subjects
INCOME tax laws, RECESSIONS, LAYOFFS, PROTECTIONISM
Abstract

The article focuses on the complexity of income tax system to the general public of the U.S. The complexity tends to be useful to the politicians though it is inconvenient to the general public. Survey shows that the tax industry is the closest thing to recession-proof under the economy that was threatened by giant deficits, layoffs and protectionism. The tax industry also extends beyond the capital.

Published
1988

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