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2. Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.

Author

George, Julie, Walter, Vonn, Peifer, Martin, Alexandrov, Ludmil B, Seidel, Danila, Leenders, Frauke, Maas, Lukas, Müller, Christian, Dahmen, Ilona, Delhomme, Tiffany M, Ardin, Maude, Leblay, Noemie, Byrnes, Graham, Sun, Ruping, De Reynies, Aurélien, McLeer-Florin, Anne, Bosco, Graziella, Malchers, Florian, Menon, Roopika, Altmüller, Janine, Becker, Christian, Nürnberg, Peter, Achter, Viktor, Lang, Ulrich, Schneider, Peter M, Bogus, Magdalena, Soloway, Matthew G, Wilkerson, Matthew D, Cun, Yupeng, McKay, James D, Moro-Sibilot, Denis, Brambilla, Christian G, Lantuejoul, Sylvie, Lemaitre, Nicolas, Soltermann, Alex, Weder, Walter, Tischler, Verena, Brustugun, Odd Terje, Lund-Iversen, Marius, Helland, Åslaug, Solberg, Steinar, Ansén, Sascha, Wright, Gavin, Solomon, Benjamin, Roz, Luca, Pastorino, Ugo, Petersen, Iver, Clement, Joachim H, Sänger, Jörg, Wolf, Jürgen, Vingron, Martin, Zander, Thomas, Perner, Sven, Travis, William D, Haas, Stefan A, Olivier, Magali, Foll, Matthieu, Büttner, Reinhard, Hayes, David Neil, Brambilla, Elisabeth, Fernandez-Cuesta, Lynnette, and Thomas, Roman K

Subjects
Humans, Neuroendocrine Tumors, Carcinoma, Neuroendocrine, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Immunohistochemistry, In Situ Hybridization, Fluorescence, DNA Mutational Analysis, Genomics, Small Cell Lung Carcinoma, High-Throughput Nucleotide Sequencing, In Vitro Techniques, Carcinoma, Neuroendocrine, Non-Small-Cell Lung, In Situ Hybridization, Fluorescence
Abstract

Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other lung cancers, but their precise relationship has remained unclear. Here we perform a comprehensive genomic (n = 60) and transcriptomic (n = 69) analysis of 75 LCNECs and identify two molecular subgroups: "type I LCNECs" with bi-allelic TP53 and STK11/KEAP1 alterations (37%), and "type II LCNECs" enriched for bi-allelic inactivation of TP53 and RB1 (42%). Despite sharing genomic alterations with adenocarcinomas and squamous cell carcinomas, no transcriptional relationship was found; instead LCNECs form distinct transcriptional subgroups with closest similarity to SCLC. While type I LCNECs and SCLCs exhibit a neuroendocrine profile with ASCL1high/DLL3high/NOTCHlow, type II LCNECs bear TP53 and RB1 alterations and differ from most SCLC tumors with reduced neuroendocrine markers, a pattern of ASCL1low/DLL3low/NOTCHhigh, and an upregulation of immune-related pathways. In conclusion, LCNECs comprise two molecularly defined subgroups, and distinguishing them from SCLC may allow stratified targeted treatment of high-grade neuroendocrine lung tumors.

Published
2018

5. 28 Magnetic hybrid materials interact with biological matrices

Author

Gräfe, Christine, primary, Müller, Elena K., additional, Gresing, Lennart, additional, Weidner, Andreas, additional, Radon, Patricia, additional, Friedrich, Ralf P., additional, Alexiou, Christoph, additional, Wiekhorst, Frank, additional, Dutz, Silvio, additional, and Clement, Joachim H., additional

Published
2021
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6. 6 Hybrid nanomaterials of biomolecule corona coated magnetic nanoparticles and their interaction with biological systems

Author

Dutz, Silvio, primary, Weidner, Andreas, additional, Lühe, Moritz von der, additional, Gräfe, Christine, additional, Biehl, Philip, additional, Demut, Johanna, additional, Warncke, Paul, additional, Jungmann, Sandra, additional, Fischer, Dagmar, additional, Schacher, Felix H., additional, and Clement, Joachim H., additional

Published
2021
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9. Data from CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, primary, Osada, Hirotaka, primary, Sun, Ruping, primary, Menon, Roopika, primary, Leenders, Frauke, primary, Ortiz-Cuaran, Sandra, primary, Peifer, Martin, primary, Bos, Marc, primary, Daßler, Juliane, primary, Malchers, Florian, primary, Schöttle, Jakob, primary, Vogel, Wenzel, primary, Dahmen, Ilona, primary, Koker, Mirjam, primary, Ullrich, Roland T., primary, Wright, Gavin M., primary, Russell, Prudence A., primary, Wainer, Zoe, primary, Solomon, Benjamin, primary, Brambilla, Elisabeth, primary, Nagy-Mignotte, Hélène, primary, Moro-Sibilot, Denis, primary, Brambilla, Christian G., primary, Lantuejoul, Sylvie, primary, Altmüller, Janine, primary, Becker, Christian, primary, Nürnberg, Peter, primary, Heuckmann, Johannes M., primary, Stoelben, Erich, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Sänger, Jörg, primary, Muscarella, Lucia A., primary, la Torre, Annamaria, primary, Fazio, Vito M., primary, Lahortiga, Idoya, primary, Perera, Timothy, primary, Ogata, Souichi, primary, Parade, Marc, primary, Brehmer, Dirk, primary, Vingron, Martin, primary, Heukamp, Lukas C., primary, Buettner, Reinhard, primary, Zander, Thomas, primary, Wolf, Jürgen, primary, Perner, Sven, primary, Ansén, Sascha, primary, Haas, Stefan A., primary, Yatabe, Yasushi, primary, and Thomas, Roman K., primary

Published
2023
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10. Data from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Author

Hammerman, Peter S., primary, Sos, Martin L., primary, Ramos, Alex H., primary, Xu, Chunxiao, primary, Dutt, Amit, primary, Zhou, Wenjun, primary, Brace, Lear E., primary, Woods, Brittany A., primary, Lin, Wenchu, primary, Zhang, Jianming, primary, Deng, Xianming, primary, Lim, Sang Min, primary, Heynck, Stefanie, primary, Peifer, Martin, primary, Simard, Jeffrey R., primary, Lawrence, Michael S., primary, Onofrio, Robert C., primary, Salvesen, Helga B., primary, Seidel, Danila, primary, Zander, Thomas, primary, Heuckmann, Johannes M., primary, Soltermann, Alex, primary, Moch, Holger, primary, Koker, Mirjam, primary, Leenders, Frauke, primary, Gabler, Franziska, primary, Querings, Silvia, primary, Ansén, Sascha, primary, Brambilla, Elisabeth, primary, Brambilla, Christian, primary, Lorimier, Philippe, primary, Brustugun, Odd Terje, primary, Helland, Åslaug, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Groen, Harry, primary, Timens, Wim, primary, Sietsma, Hannie, primary, Stoelben, Erich, primary, Wolf, Jürgen, primary, Beer, David G., primary, Tsao, Ming Sound, primary, Hanna, Megan, primary, Hatton, Charles, primary, Eck, Michael J., primary, Janne, Pasi A., primary, Johnson, Bruce E., primary, Winckler, Wendy, primary, Greulich, Heidi, primary, Bass, Adam J., primary, Cho, Jeonghee, primary, Rauh, Daniel, primary, Gray, Nathanael S., primary, Wong, Kwok-Kin, primary, Haura, Eric B., primary, Thomas, Roman K., primary, and Meyerson, Matthew, primary

Published
2023
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11. Interview with Dr. Meyerson from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Author

Hammerman, Peter S., primary, Sos, Martin L., primary, Ramos, Alex H., primary, Xu, Chunxiao, primary, Dutt, Amit, primary, Zhou, Wenjun, primary, Brace, Lear E., primary, Woods, Brittany A., primary, Lin, Wenchu, primary, Zhang, Jianming, primary, Deng, Xianming, primary, Lim, Sang Min, primary, Heynck, Stefanie, primary, Peifer, Martin, primary, Simard, Jeffrey R., primary, Lawrence, Michael S., primary, Onofrio, Robert C., primary, Salvesen, Helga B., primary, Seidel, Danila, primary, Zander, Thomas, primary, Heuckmann, Johannes M., primary, Soltermann, Alex, primary, Moch, Holger, primary, Koker, Mirjam, primary, Leenders, Frauke, primary, Gabler, Franziska, primary, Querings, Silvia, primary, Ansén, Sascha, primary, Brambilla, Elisabeth, primary, Brambilla, Christian, primary, Lorimier, Philippe, primary, Brustugun, Odd Terje, primary, Helland, Åslaug, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Groen, Harry, primary, Timens, Wim, primary, Sietsma, Hannie, primary, Stoelben, Erich, primary, Wolf, Jürgen, primary, Beer, David G., primary, Tsao, Ming Sound, primary, Hanna, Megan, primary, Hatton, Charles, primary, Eck, Michael J., primary, Janne, Pasi A., primary, Johnson, Bruce E., primary, Winckler, Wendy, primary, Greulich, Heidi, primary, Bass, Adam J., primary, Cho, Jeonghee, primary, Rauh, Daniel, primary, Gray, Nathanael S., primary, Wong, Kwok-Kin, primary, Haura, Eric B., primary, Thomas, Roman K., primary, and Meyerson, Matthew, primary

Published
2023
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12. Supplementary Tables from CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, primary, Osada, Hirotaka, primary, Sun, Ruping, primary, Menon, Roopika, primary, Leenders, Frauke, primary, Ortiz-Cuaran, Sandra, primary, Peifer, Martin, primary, Bos, Marc, primary, Daßler, Juliane, primary, Malchers, Florian, primary, Schöttle, Jakob, primary, Vogel, Wenzel, primary, Dahmen, Ilona, primary, Koker, Mirjam, primary, Ullrich, Roland T., primary, Wright, Gavin M., primary, Russell, Prudence A., primary, Wainer, Zoe, primary, Solomon, Benjamin, primary, Brambilla, Elisabeth, primary, Nagy-Mignotte, Hélène, primary, Moro-Sibilot, Denis, primary, Brambilla, Christian G., primary, Lantuejoul, Sylvie, primary, Altmüller, Janine, primary, Becker, Christian, primary, Nürnberg, Peter, primary, Heuckmann, Johannes M., primary, Stoelben, Erich, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Sänger, Jörg, primary, Muscarella, Lucia A., primary, la Torre, Annamaria, primary, Fazio, Vito M., primary, Lahortiga, Idoya, primary, Perera, Timothy, primary, Ogata, Souichi, primary, Parade, Marc, primary, Brehmer, Dirk, primary, Vingron, Martin, primary, Heukamp, Lukas C., primary, Buettner, Reinhard, primary, Zander, Thomas, primary, Wolf, Jürgen, primary, Perner, Sven, primary, Ansén, Sascha, primary, Haas, Stefan A., primary, Yatabe, Yasushi, primary, and Thomas, Roman K., primary

Published
2023
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13. Supplementary Figure Legends 1-7 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Author

Hammerman, Peter S., primary, Sos, Martin L., primary, Ramos, Alex H., primary, Xu, Chunxiao, primary, Dutt, Amit, primary, Zhou, Wenjun, primary, Brace, Lear E., primary, Woods, Brittany A., primary, Lin, Wenchu, primary, Zhang, Jianming, primary, Deng, Xianming, primary, Lim, Sang Min, primary, Heynck, Stefanie, primary, Peifer, Martin, primary, Simard, Jeffrey R., primary, Lawrence, Michael S., primary, Onofrio, Robert C., primary, Salvesen, Helga B., primary, Seidel, Danila, primary, Zander, Thomas, primary, Heuckmann, Johannes M., primary, Soltermann, Alex, primary, Moch, Holger, primary, Koker, Mirjam, primary, Leenders, Frauke, primary, Gabler, Franziska, primary, Querings, Silvia, primary, Ansén, Sascha, primary, Brambilla, Elisabeth, primary, Brambilla, Christian, primary, Lorimier, Philippe, primary, Brustugun, Odd Terje, primary, Helland, Åslaug, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Groen, Harry, primary, Timens, Wim, primary, Sietsma, Hannie, primary, Stoelben, Erich, primary, Wolf, Jürgen, primary, Beer, David G., primary, Tsao, Ming Sound, primary, Hanna, Megan, primary, Hatton, Charles, primary, Eck, Michael J., primary, Janne, Pasi A., primary, Johnson, Bruce E., primary, Winckler, Wendy, primary, Greulich, Heidi, primary, Bass, Adam J., primary, Cho, Jeonghee, primary, Rauh, Daniel, primary, Gray, Nathanael S., primary, Wong, Kwok-Kin, primary, Haura, Eric B., primary, Thomas, Roman K., primary, and Meyerson, Matthew, primary

Published
2023
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14. Supplementary Figures 1-7 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Author

Hammerman, Peter S., primary, Sos, Martin L., primary, Ramos, Alex H., primary, Xu, Chunxiao, primary, Dutt, Amit, primary, Zhou, Wenjun, primary, Brace, Lear E., primary, Woods, Brittany A., primary, Lin, Wenchu, primary, Zhang, Jianming, primary, Deng, Xianming, primary, Lim, Sang Min, primary, Heynck, Stefanie, primary, Peifer, Martin, primary, Simard, Jeffrey R., primary, Lawrence, Michael S., primary, Onofrio, Robert C., primary, Salvesen, Helga B., primary, Seidel, Danila, primary, Zander, Thomas, primary, Heuckmann, Johannes M., primary, Soltermann, Alex, primary, Moch, Holger, primary, Koker, Mirjam, primary, Leenders, Frauke, primary, Gabler, Franziska, primary, Querings, Silvia, primary, Ansén, Sascha, primary, Brambilla, Elisabeth, primary, Brambilla, Christian, primary, Lorimier, Philippe, primary, Brustugun, Odd Terje, primary, Helland, Åslaug, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Groen, Harry, primary, Timens, Wim, primary, Sietsma, Hannie, primary, Stoelben, Erich, primary, Wolf, Jürgen, primary, Beer, David G., primary, Tsao, Ming Sound, primary, Hanna, Megan, primary, Hatton, Charles, primary, Eck, Michael J., primary, Janne, Pasi A., primary, Johnson, Bruce E., primary, Winckler, Wendy, primary, Greulich, Heidi, primary, Bass, Adam J., primary, Cho, Jeonghee, primary, Rauh, Daniel, primary, Gray, Nathanael S., primary, Wong, Kwok-Kin, primary, Haura, Eric B., primary, Thomas, Roman K., primary, and Meyerson, Matthew, primary

Published
2023
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15. Supplementary Table 1 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Author

Hammerman, Peter S., primary, Sos, Martin L., primary, Ramos, Alex H., primary, Xu, Chunxiao, primary, Dutt, Amit, primary, Zhou, Wenjun, primary, Brace, Lear E., primary, Woods, Brittany A., primary, Lin, Wenchu, primary, Zhang, Jianming, primary, Deng, Xianming, primary, Lim, Sang Min, primary, Heynck, Stefanie, primary, Peifer, Martin, primary, Simard, Jeffrey R., primary, Lawrence, Michael S., primary, Onofrio, Robert C., primary, Salvesen, Helga B., primary, Seidel, Danila, primary, Zander, Thomas, primary, Heuckmann, Johannes M., primary, Soltermann, Alex, primary, Moch, Holger, primary, Koker, Mirjam, primary, Leenders, Frauke, primary, Gabler, Franziska, primary, Querings, Silvia, primary, Ansén, Sascha, primary, Brambilla, Elisabeth, primary, Brambilla, Christian, primary, Lorimier, Philippe, primary, Brustugun, Odd Terje, primary, Helland, Åslaug, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Groen, Harry, primary, Timens, Wim, primary, Sietsma, Hannie, primary, Stoelben, Erich, primary, Wolf, Jürgen, primary, Beer, David G., primary, Tsao, Ming Sound, primary, Hanna, Megan, primary, Hatton, Charles, primary, Eck, Michael J., primary, Janne, Pasi A., primary, Johnson, Bruce E., primary, Winckler, Wendy, primary, Greulich, Heidi, primary, Bass, Adam J., primary, Cho, Jeonghee, primary, Rauh, Daniel, primary, Gray, Nathanael S., primary, Wong, Kwok-Kin, primary, Haura, Eric B., primary, Thomas, Roman K., primary, and Meyerson, Matthew, primary

Published
2023
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16. Supplementary Figures from CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, primary, Osada, Hirotaka, primary, Sun, Ruping, primary, Menon, Roopika, primary, Leenders, Frauke, primary, Ortiz-Cuaran, Sandra, primary, Peifer, Martin, primary, Bos, Marc, primary, Daßler, Juliane, primary, Malchers, Florian, primary, Schöttle, Jakob, primary, Vogel, Wenzel, primary, Dahmen, Ilona, primary, Koker, Mirjam, primary, Ullrich, Roland T., primary, Wright, Gavin M., primary, Russell, Prudence A., primary, Wainer, Zoe, primary, Solomon, Benjamin, primary, Brambilla, Elisabeth, primary, Nagy-Mignotte, Hélène, primary, Moro-Sibilot, Denis, primary, Brambilla, Christian G., primary, Lantuejoul, Sylvie, primary, Altmüller, Janine, primary, Becker, Christian, primary, Nürnberg, Peter, primary, Heuckmann, Johannes M., primary, Stoelben, Erich, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Sänger, Jörg, primary, Muscarella, Lucia A., primary, la Torre, Annamaria, primary, Fazio, Vito M., primary, Lahortiga, Idoya, primary, Perera, Timothy, primary, Ogata, Souichi, primary, Parade, Marc, primary, Brehmer, Dirk, primary, Vingron, Martin, primary, Heukamp, Lukas C., primary, Buettner, Reinhard, primary, Zander, Thomas, primary, Wolf, Jürgen, primary, Perner, Sven, primary, Ansén, Sascha, primary, Haas, Stefan A., primary, Yatabe, Yasushi, primary, and Thomas, Roman K., primary

Published
2023
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29. Biocompatible Magnetic Fluids of Co-Doped Iron Oxide Nanoparticles with Tunable Magnetic Properties

Author

Dutz, Silvio, Buske, Norbert, Landers, Joachim, Gr��fe, Christine, Wende, Heiko, and Clement, Joachim H.

Subjects
magnetic fluid hyperthermia, lcsh:Chemistry, magnetic nanoparticles, magnetite, cobalt ferrite, lcsh:QD1-999, coercivity, Physik (inkl. Astronomie), Article, ferrimagnetism
Abstract

Magnetite (Fe3O4) particles with a diameter around 10 nm have a very low coercivity (Hc) and relative remnant magnetization (Mr/Ms), which is unfavorable for magnetic fluid hyperthermia. In contrast, cobalt ferrite (CoFe2O4) particles of the same size have a very high Hc and Mr/Ms, which is magnetically too hard to obtain suitable specific heating power (SHP) in hyperthermia. For the optimization of the magnetic properties, the Fe2+ ions of magnetite were substituted by Co2+ step by step, which results in a Co doped iron oxide inverse spinel with an adjustable Fe2+ substitution degree in the full range of pure iron oxide up to pure cobalt ferrite. The obtained magnetic nanoparticles were characterized regarding their structural and magnetic properties as well as their cell toxicity. The pure iron oxide particles showed an average size of 8 nm, which increased up to 12 nm for the cobalt ferrite. For ferrofluids containing the prepared particles, only a limited dependence of Hc and Mr/Ms on the Co content in the particles was found, which confirms a stable dispersion of the particles within the ferrofluid. For dry particles, a strong correlation between the Co content and the resulting Hc and Mr/Ms was detected. For small substitution degrees, only a slight increase in Hc was found for the increasing Co content, whereas for a substitution of more than 10% of the Fe atoms by Co, a strong linear increase in Hc and Mr/Ms was obtained. Mössbauer spectroscopy revealed predominantly Fe3+ in all samples, while also verifying an ordered magnetic structure with a low to moderate surface spin canting. Relative spectral areas of Mössbauer subspectra indicated a mainly random distribution of Co2+ ions rather than the more pronounced octahedral site-preference of bulk CoFe2O4. Cell vitality studies confirmed no increased toxicity of the Co-doped iron oxide nanoparticles compared to the pure iron oxide ones. Magnetic heating performance was confirmed to be a function of coercivity as well. The here presented non-toxic magnetic nanoparticle system enables the tuning of the magnetic properties of the particles without a remarkable change in particles size. The found heating performance is suitable for magnetic hyperthermia application.

Published
2020

36. Magnetic hybrid materials interact with biological matrices

Author

Gräfe, Christine, primary, Müller, Elena K., additional, Gresing, Lennart, additional, Weidner, Andreas, additional, Radon, Patricia, additional, Friedrich, Ralf P., additional, Alexiou, Christoph, additional, Wiekhorst, Frank, additional, Dutz, Silvio, additional, and Clement, Joachim H., additional

Published
2020
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37. Hybrid nanomaterials of biomolecule corona coated magnetic nanoparticles and their interaction with biological systems

Author

Dutz, Silvio, primary, Weidner, Andreas, additional, von der Lühe, Moritz, additional, Gräfe, Christine, additional, Biehl, Philip, additional, Demut, Johanna, additional, Warncke, Paul, additional, Jungmann, Sandra, additional, Fischer, Dagmar, additional, Schacher, Felix H., additional, and Clement, Joachim H., additional

Published
2020
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39. Polymethine Dye-Functionalized Nanoparticles for Targeting CML Stem Cells

Author

Ernst, Philipp, primary, Press, Adrian T., additional, Fischer, Mike, additional, Günther, Vivien, additional, Gräfe, Christine, additional, Clement, Joachim H., additional, Ernst, Thomas, additional, Schubert, Ulrich S., additional, Wotschadlo, Jana, additional, Lehmann, Marc, additional, Enzensperger, Christoph, additional, Bauer, Michael, additional, and Hochhaus, Andreas, additional

Published
2020
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46. Comparative proteomic analysis of normal and tumor stromal cells by tissue on chip based mass spectrometry (toc-MS)

Author

Friedrich Karlheinz, Junker Kerstin, Clement Joachim H, Berndt Alexander, Melle Christian, Ernst Günther, Escher Niko, Guntinas-Lichius Orlando, and von Eggeling Ferdinand

Subjects
Pathology, RB1-214
Abstract

Abstract In carcinoma tissues, genetic and metabolic changes not only occur at the tumor cell level, but also in the surrounding stroma. This carcinoma-reactive stromal tissue is heterogeneous and consists e.g. of non-epithelial cells such as fibroblasts or fibrocytes, inflammatory cells and vasculature-related cells, which promote carcinoma growth and progression of carcinomas. Nevertheless, there is just little knowledge about the proteomic changes from normal connective tissue to tumor stroma. In the present study, we acquired and analysed specific protein patterns of small stromal sections surrounding head and neck cell complexes in comparison to normal subepithelial connective tissue. To gain defined stromal areas we used laser-based tissue microdissection. Because these stromal areas are limited in size we established the highly sensitive 'tissue on chip based mass spectrometry' (toc-MS). Therefore, the dissected areas were directly transferred to chromatographic arrays and the proteomic profiles were subsequently analysed with mass spectrometry. At least 100 cells were needed for an adequate spectrum. The locating of differentially expressed proteins enables a precise separation of normal and tumor stroma. The newly described toc-MS technology allows an initial insight into proteomic differences between small numbers of exactly defined cells from normal and tumor stroma.

Published
2010
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47. Multi-omics comparative analyses of pulmonary typical carcinoids, atypical carcinoids, and large-cell neuroendocrine carcinoma

Author

Leblay, Noemie, Alcala, Nicolas, Marin, David Hervas, Delhomme, Tiffany M., Giffon, Theo, Ghantous, Akram, Chabrier, Amelie, Cuenin, Cyrille, Altmueller, Janine, Durand, Geoffroy, Voegele, Catherine, Lorimier, Philippe, Toffart, Anne-Claire, Derks, Jules, Brustugun, Odd Terje, Clement, Joachim H., Saenger, Joerg, Field, John K., Soltermann, Alex, Wright, Gavin M., Roz, Luca, Muscarella, Lucia Anna, Graziano, Paolo, Herceg, Zdenko, Speel, Ernst-Jan, Nuernberg, Peter, McKay, James, Girard, Nicolas, Lantuejoul, Sylvie, Sandoval, Juan, Brambilla, Elisabeth, Foll, Matthieu, Fernandez-Cuesta, Lynnette, Leblay, Noemie, Alcala, Nicolas, Marin, David Hervas, Delhomme, Tiffany M., Giffon, Theo, Ghantous, Akram, Chabrier, Amelie, Cuenin, Cyrille, Altmueller, Janine, Durand, Geoffroy, Voegele, Catherine, Lorimier, Philippe, Toffart, Anne-Claire, Derks, Jules, Brustugun, Odd Terje, Clement, Joachim H., Saenger, Joerg, Field, John K., Soltermann, Alex, Wright, Gavin M., Roz, Luca, Muscarella, Lucia Anna, Graziano, Paolo, Herceg, Zdenko, Speel, Ernst-Jan, Nuernberg, Peter, McKay, James, Girard, Nicolas, Lantuejoul, Sylvie, Sandoval, Juan, Brambilla, Elisabeth, Foll, Matthieu, and Fernandez-Cuesta, Lynnette

Published
2018

48. Abstract 5358: Multi-omics comparative analyses of pulmonary typical carcinoids, atypical carcinoids, and large-cell neuroendocrine carcinoma

Author

Leblay, Noémie, primary, Alcala, Nicolas, additional, Marin, David Hervás, additional, Delhomme, Tiffany M., additional, Giffon, Théo, additional, Ghantous, Akram, additional, Chabrier, Amélie, additional, Cuenin, Cyrille, additional, Altmueller, Janine, additional, Durand, Geoffroy, additional, Voegele, Catherine, additional, Lorimier, Philippe, additional, Toffart, Anne-Claire, additional, Derks, Jules, additional, Brustugun, Odd Terje, additional, Clement, Joachim H., additional, Saenger, Joerg, additional, Field, John K., additional, Soltermann, Alex, additional, Wright, Gavin M., additional, Roz, Luca, additional, Muscarella, Lucia Anna, additional, Graziano, Paolo, additional, Herceg, Zdenko, additional, Speel, Ernst-Jan, additional, Nuernberg, Peter, additional, McKay, James, additional, Girard, Nicolas, additional, Lantuejoul, Sylvie, additional, Sandoval, Juan, additional, Brambilla, Elisabeth, additional, Foll, Matthieu, additional, and Fernandez-Cuesta, Lynnette, additional

Published
2018
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50. Macromol. Rapid Commun. 4/2017

Author

Billing, Mark, primary, Gräfe, Christine, additional, Saal, Adrian, additional, Biehl, Philip, additional, Clement, Joachim H., additional, Dutz, Silvio, additional, Weidner, Steffen, additional, and Schacher, Felix H., additional

Published
2017
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