13 results on '"Clemenceau, B."'
Search Results
2. Production de MTI de grade clinique par l’EFS Atlantic Bio GMP : transposition d’échelle, validation et production de lymphocytes T cytotoxiques anti-CMV tierce partie
- Author
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Derenne, S., primary, Tertrais, K., additional, Chartois, A.-G., additional, Auffray, F., additional, Clemenceau, B., additional, and Vie, H., additional
- Published
- 2013
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Catalog
3. Selection of Epstein-Barr virus specific cytotoxic T lymphocytes can be performed with B lymphoblastoid cell lines created in serum-free media
- Author
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Gallot, G., primary, Vollant, S., additional, Vivien, R., additional, Clemenceau, B., additional, Ferrand, C., additional, Tiberghien, P., additional, Gaschet, J., additional, Robillard, N., additional, and Vie, H., additional more...
- Published
- 2006
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4. In vitro co-incubation of pig islet cells with xenogeneic human blood mononuclear cells causes loss of insulin release during perifusion: involvement of non-T-cell- and T-cell-mediated mechanisms
- Author
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Lalain, S., Clemenceau, B., Gouin, E., and Sai, P.
- Published
- 2001
- Full Text
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5. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999
- Author
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Ad Darts Memo, Morris For The Collaboration, Juhl, C., Porksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th, Muller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Bjorn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H-M, Oksanen, L., Tuomainen, T-P, Kontula, K., Salonen, J. T., Dekker, J. M., Boks, P., Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., Macalpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M. Jr, Kozakova, H., Kaas, A., Kofronova, O., Tlaskalova-Hogenova, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sorensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Hasko, G., Szabo, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. P., Lund, S. S., Rossing, P., Jensen, T., Parving, H-H, Genediab, Study Group, Andersen, S., Tarnow, L., Hansen, B. V., Trautner, C., Haastert, B., Ennenbach, N., Willich, S., Tabak, A. Gy, Orchard, T. J., Spranger, J., Preissner, K. T., Schatz, H., Pfeiffer, A., Canton, A., Burgos, R., Hernandez, C., Lecube, A., Mesa, J., Segura, R. M., Mateo, C., Simo, R., Fathallah, L., Greene, D. A., Obrosova, I., Gilbert, R. E., Kelly, D. J., Cox, A. J., Berka-Wilkinson, J. L., Taylor, H. R., Panagiotopoulos, S., Lee, V., Jerums, G., Cooper, M. E., Hitman, G. A., Aganna, E., Ogunkolade, W. B., Rema, M., Deepa, R., Shanthi-Rani, C. S., Barakat, K., Kumarajeewa, T. R., Cassell, P. G., Mcdermott, M. F., Mohan, V., Ways, K., Bursell, S., Devries, T., Woodworth, J., Alatorre, C., King, G., Aiello, L. P., Karisen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L., Nerup, J., Lortz, S., Tiedge, M., Lenzen, S., Lally, F. J., Bone, A. J., Darville, M. I., Ho, Y-S, Sternesjo, J., Sandler, S., Chen, M-C, Schuit, F., Pipeleers, D. G., Merezak, S., Hardikar, A., Hoet, J. J., Remacle, C., Reusens, B., Breant, B., Garofano, A., Czernichow, P., Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Nakano, R., Komeda, K., Eto, K., Tobe, K., Kimura, S., Kadowaki, T., Ide, T., Murakami, K., Tsunoda, M., Mochizuki, T., Ozanne, S. E., Nave, B. T., Wang, C. L., Dorling, M. W., Petry, C. J., Koopmans, S. J., Bent, C., Que, I., Radder, J. K., Sebokova, E., Sana, A. K., Klimes, I., Ruderman, N., Morviducci, L., Pastore, L., Morelli, S., Sagratella, E., Zorretta, D., Buongiomo, A., Tamburrano, G., Giaccari, A., Martinenghi, Sabina, Angelis, Gabriella Cusella, Ravasi, Flavio, Bifari, Francesco, Bordignon, Claudio, Falqui, Luca, Kessler, A., Dransfeld, O., Sasson, S., Tomas, E., Zorzano, A., Eckel, J., Thorsby, P., Rosenfalck, A. M., Kjems, L., Hanssen, K. F., Madsbad, S., Birkeland, K. I., Hamilton-Wessler, M., Markussen, J., Bergman, R. N., Melki, V., Hanaire-Broutin, H., Bessieres-Lacombe, S., Gedec, Study Group, Tauber, J-P, Home, P. D., Lindholm, A., Riis, A., European Insulin Aspart Study Group, Rosenstock, J., Schwartz, S., Clark, C., Edwards, M., Donley, D., Us Dm, Study Group Of Insulin Glargine In Type, Swift, P., Mortensen, H. B., Lynggaard, H., Hougaard, P., Hvidore Study group on Childhood Diabetes, Cull, C. A., Neil, H. A. W., Frighi, V., Manley, S. E., Holman, R. R., Turner, R. C., Ukpds, Group, Steiner, G., Dais, Project Group, Davis, W. A., Weeraratna, T., Bruce, D. G., Davis, T. M. E., Verges, B., Duvillard, L., Pont, F., Florentin, E., Gambert, Ph, Benko, B., Ljubic, S., Turk, Z., Granic, M., Marz, W., Wollschlager, H., Klein, G., Neiss, A., Wehling, M., Huxtable, S. J., Saker, P. J., Walker, M., Frayling, T. M., Levy, J. C., O Rahilly, S., Hattersley, A. T., Mccarthy, M. I., Orecchio, A., Giacchini, A., Dominici, R., Canettieri, G., Trinti, B., Zani, M., Andreoli, M., Sciacchitano, S., Silva, A. M., Whitecross, K., Pasco, J., Kotowicz, M., Nicholson, G., Zimmet, P., Boyko, E. J., Collier, G. R., Frittitta, L., Pizzuti, A., Argiolas, A., Graci, S., Goldfine, I. D., Bozzali, M., Ercolino, T., Costanzo, B., Iacoviello, L., Tassi, V., Trischitta, V., Wauters, M., Rankinen, T., Mertens, I., Chagnon, M., Bouchard, C., Gaal, L., Sivenius, K., Valve, R., Hakkarainen, V., Niskanen, L., Laakso, M., Uusitupa, M., Beridze, N., Japaridze, M., Kurashvili, R., Dundua, M., Kebuladze, G., Kazakhashvili, N., Offley-Shore, B., Thomas, B., Ghebremeskel, K., Crawford, M., Lowy, C., Eriksson, Ulf J., Martin Siman, C., Wisse, Bert, Gittenberger-De Groot, Adriana C., Wentzel, P., Eriksson, U. J., Wender-Ozegowska, E., Drews, K., Biczysko, R., Bronisz, A., Rosc, D., Graczykowska-Koczorowska, A., Kotschy, M., Sokup, A., Kohnert, K. D., Besch, W., Strese, J., Frick, U., Zander, E., Kemer, W., Skrha, J., Kvasnicka, J., Kalvodova, B., Hilgertova, J., Schatteman, K., Goossens, F., Scharpe, S., Leeuw, I., Hendriks, D., Legakis, I. N., Panayiotou, D., Mountokalakis, Th D., Enderle, M. D., Beckmann, P., Balletshofer, B., Rittig, K., Maerker, E., Volk, A., Meisner, C., Jacob, S., Matthaei, S., Haring, H. U., Rett, K., Ueda, K., Nakagawa, T., Shimajiri, Y., Kokawa, M., Matsumoto, E., Sasaki, H., Sanke, T., Nanjo, K., Mckinnon, Caroline M., Macfarlane, Wendy M., Docherty, Kevin, Furukawa, N., Shirotani, T., Kishikawa, H., Kaneko, K., Araki, E., Shichiri, M., Prentki, M., Roduit, R., Susini, S., Buteau, J., Ejrnas, A. M., Andersen, N. Aa, Osterhoff, M., Mohlig, M., Ortmann, J., Bikashaghi, F., Mayer, C., Bikashagi, F., Ackermans, M. T., Pereira Arias, A. M., Bisschop, P. H. L. T., Endert, E., Sauerwein, H. P., Romijn, J. A., Gastaldelli, A., Baldi, S., Pettiti, M., Natali, A., Frascerra, S., Camastra, S., Toschi, E., Ferrannini, E., Stingl, H., Krssak, M., Bischof, M. G., Krebs, M., Furnsinn, C., Nowotny, P., Waldhausl, W., Roden, M., Neeft, M., Meijer, A. J., Bavenholm, P., Pigon, J., Efendic, S., Kastenbauer, T., Sauseng, S., Sokol, G., Auinger, M., Irsigler, K., Abbott, C. A., Carrington, A. L., Faragher, B., Kulkarni, J., Ross, E. R. E., Boulton, A. J. M., Armstrong, D. G., Hadi, S., Nguyen, H. C., Harkless, L. B., Jirkovska, A., Kasalicky, P., Hosova, J., Skibova, J., Uccioli, L., Caselli, A., Giacomozzi, C., Macellari, V., Giurato, L., Lardieri, L., Menzinger, G., Pham, H. T., Rosenblum, B. I., Lyons, T. E., Giurini, J. M., Smakowski, P., Chrzan, J. S., Habershaw, G. M., Veves, A., Foster, A. M., Bates, M., Doxford, M., Edmonds, M. E., Kecha, O., Winkler, R., Martens, H., Collette, J., Lefebvre, P. J., Greiner, D., Geenen, V., Atlan-Gepner, C., Naspetti, M., Valero, R., Barad, M., Lepault, F., Vialettes, B., Naquet, P., Galan, B., Netea, M. G., Hancu, N., Smits, P., Meer, J. W. M., Osterbye, T., Jorgensen, K. H., Tranum-Jensen, J., Fredman, P., Hoy, M., Bokvist, K., Olsen, H. L., Horn, T., Gromada, J., Laub, R., Lohmann, T., Hahn, H. J., Adler, T., Emmrich, F., Rabuazzo, A. M., Lupi, R., Dotta, F., Patane, G., Marselli, L., Realacci, M., Piro, S., Del Guerra, S., Santangelo, C., Navalesi, R., Purrello, F., Marchetti, P., Vos, P., Visser, L., Haan, B. J., Klok, P., Schilfgaarde, R., Poppema, S., Juang, J-H, Kuo, C-H, Hsu, B. R-S, Nacher, V., Perez, M., Biarnes, M., Raurell, M., Soler, J., Montanya, E., Ritzel, R., Maubach, J., Busing, M., Becker, T., Klempnauer, J., Hucking, K., Schmiegel, W. H., Nauck, M. A., Boucek, P., Saudek, F., Adamec, M., Kozitarova, R., Jedinakova, T., Vlasakova, Z., Bartos, V., Maffi, P., Bertuzzi, F., Aldrighetti, L., Taglietti, M. V., Castelnuovo, A., Pozza, G., Di Carlo, V., Secchi, A., Renier, G., Mamputu, J-C, Gillespie, J. S., Mcmaster, D., Mercer, C., Trimble, E. R., Lecomte, M., Vericel, E., Paget, C., Ruggiero, D., Lagarde, M., Wiernsperger, N., Pricci, F., Leto, G., Amadio, L., Cordone, S., Iacobini, C., Catalano, S., Violi, F., Rotella, C. M., Pugliese, G., Zicari, A., Gradini, R., Sale, P., Pala, L., Cresci, B., Giannini, S., Manuelli, C., Dahlfors, G., Arnqvist, H. J., Gonelle-Gispert, C., Halnan, P. A., Sadoul, K., Wolter, S., Lang, J., Niwa, T., Yu, W., Hidaka, H., Senda, T., Niki, I., Fukasawa, T., Renstrom, E., Barg, S., Seward, E., Rorsman, P., Rutter, G. A., Molinete, M., Lilla, V., Ravazzola, M., Halban, P. A., Efanov, A. M., Bertorello, A. M., Zaitsev, S. V., Zwiller, J., Berggren, P-O, Msengul, A., Salman, F., Sargrn, M., Ozer, E., Karsidaǧ, K., Salman, S., Gedik, S., Satman, I., Dinccaǧ, N., Yilmaz, M. T., Lloyd, A., Hopkinson, P. K., Testa, M. A., Blonde, L., Turner, R. R., Hayes, J., Simonson, D. C., Ven, N. C. W., Lubach, C. H. C., Snoek, F. J., Mollema, E. D., Ploeg, H. M., Danne, T., Hoey, H., Mcgee, H., Fitzgerald, H., Lernmark, B., Thernlund, G., Fredin, K., Hagglof, B., Lugari, R., Anna, C., Ugolotti, D., Dei Cas, A., Barilli, A. L., Sard, L., Marani, B., Iotti, M., Zandomeneghi, R., Gnudi, A., Kjems, L. L., Volund, Aa, Toft-Nielsen, M., Damholt, M. B., Hilsted, L., Hughes, T. E., Krarup, T., Holst, J. J., Young, A., Gottlieb, A., Fineman, M., Kolterman, O., Cancelas, J., Garcia-Martinez, J. A., Villanueva-Penacarrillo, M. L., Valverde, I., Malaisse, W. J., Filipsson, K., Ahren, B., Balkan, B., Kwasnik, L., Battle, B., Li, X., Egan, J. M., Clocquet, A. R., Elahi, D., Petrella, E., Pricket, K., Petersen, K. F., Sullivan, J. T., Amatruda, J. M., Livingston, J. N., Shulman, G. I., Freyse, E-J, Knospe, S., Glund, K., Demuth, H-U, Walker, D., Malik, R. A., Reljanovic, M., Barada, A., Milicevic, Z., Tack, Cees J., Croatian Study Group for Diabetic Amyotrophy, Goldstein, David S., Huysen, C., Stevens, M. J., Cao, X., Sundkvist, G., Dahlin, L-B, Eriksson, K-F, Rosen, I., Lattimer, S. A., Sima, A. A. F., Sullivan, K., Shaw, J. E., Courten, M. P., Zimmet, P. Z., Gourdy, P., Ruidavets, J. B., Arveiler, D., Amouyel, Ph, Bingham, A., Tauber, J. P., Lam, K. S. L., Wat, N. M. S., Lam, T. H., Janus, E. D., Pablos, P., Rodriguez, F., Martinez, J., Sanchez, V., Santana, C., Garcia, I., Macias, A., Levin, K., Hother-Nielsen, O., Henriksen, J. E., Beck-Nielsen, H., Brechtel, K., Machann, J., Koch, M., Nielsen, M., Loblein, K., Becker, R., Denignger, M., Renn, W., Machicao, F., Claussen, C. D., Schick, F., Diraison, F., Moulin, P., Beylot, M., Thams, P., Capito, K., Eliasson, Lena, Barg, Sebastian, Gopel, Sven, Kanno, Takahiro, Renstrom, Erik, Meda, P., Charollais, A., Gjnovci, A., Calabrese, A., Wonkam, A., Caton, D., Wisznievski, L., Serre, V., Cogne, F., Bauquis, J., Bosco, D., Huarte, J., Herrera, P., Gotfredsen, C. F., Vessby, B., Kanwu, Study Group, Manuel Y Keenoy, B., Engelen, W., Vertommen, J., Schrans, S., Louheranta, A., Lindstrom, J., Tuomilehto, J., Finnish Diabetes Prevention Study Group, Segal, K. R., Heymsfield, S., Hauptman, J., Boldrin, M., Lucas, C., Pandolfi, A., Cetrullo, D., Polishchuck, R., Alberta, M., Pellegrini, G., Calafiore, A., Vitacolonna, E., Capani, F., Consoli, A., Halleux, C. M., Gillot, E. F., Brichard, S. M., Planken, M., Corthouts, B., Peiffer, F., Scholten, D., Walke, M., Assert, R., Pirags, V., Pedula, K. L., Hillier, T. A., Brown, J. B., Eurodiab, Prospective Complications Study Group, Santini, S. A., Marra, G., Cotroneo, P., Manto, A., Di Leo, M. A. S., Di Gregorio, S., Tordi, A., Pitocco, D., Ruotolo, V., Ghirlanda, G., Temelkova-Kurktschiev, T., Schaper, F., Koehler, C., Henkel, E., Hanefeld, M., Mancini, L., Citterio, F., Cotroneo, A., Ceroone, S., Castagneto, M., Rajbhandari, S. M., Dent, M. T., Plater, M. E., Harris, N. D., Tesfaye, S., Ward, J. D., Dupuy, O., Mayaudon, H., Lecoules, S., Bauduceau, B., Palou, M., Farret, O., Molinie, C., Antonelli-Incalzi, R., Fuso, L., Giordano, A., Calcagni, M. L., Todaro, L., Basso, S., Tramaglino, L. M., Troncone, L., Pistelli, R., Guillot, R., Bringuier, A., Porokhov, B., Guillausseau, P. J., Feldmann, G., Zivanic, S., Cizmic, M., Dragojevic, R., Vanovic, M., Borghouts, L. B., Kranenburg, G. P. J., Schaart, G., Keizer, H. A., Niess, A. M., Dickuth, H. H., Lutz, O., Barbe, P., Calazel-Fournier, C., Hernandez, G., Saint-Martin, F., Galitzky, J., Goncalves, A. A., Da Silva, E. C., Brito, I. J. L., Da Silva, C. A., Lawrence, N. J., Kousta, E., Mulnier, H., Penny, A., Millauer, B., Johnston, D. G., Robinson, S., Perriello, G., Pimenta, W., Pampanelli, S., Lucidi, P., Lepore, M., Porcellati, F., Cordoni, M. C., Feo, P., Bolli, G. B., Sjostrand, M., Holmang, A., Lonnroth, P., Hauer, B., Grauer, P., Artzner, S., Lang, R., Stumvoll, M., Monti, L. D., Piatti, P. M., Gemone, F., Valsecchi, G., Magni, M., Barbieri, E., Setola, E., Sandoli, E. P., Galli-Kienle, M., Pontiroli, A. E., Nichols, Gregory A., Brown, Jonathan B., Salzsieder, E., Boltz, H., Ramirez, J. C., Rutscher, A., Fischer, U., Koenig, Ch, Friske, M., Schramm, W., Landgraf, R., Bachmann, W., Bangemann, M., Groeneveld, G., Edvell, Anders, Lindstrom, Per, Tsiotra, P., Koukourava, A., Raptis, S. A., Tsigos, C., Boutou, E., Triandaffilopoulou, A., Egido, E. M., Rodriguez-Gallardo, J., Gutierrez, E., Garcia, P., Silvestre, R. A., Marco, J., Khan, Akhtar, Ling, Zong-Chao, Ahren, Bo, Efendic, Suad, Bunting, C., Du, X., Zhi Sui, G., Rosen, P., Koschinsky, T., Kearney, T. M., Sharp, P. S., Lapolla, A., Fedele, D., Martano, L., Garbeglio, M., Seraglia, R., Favretto, D., Traldi, P., Meerwaldt, R., Smit, A. J., Links, Th P., V Roon, A. M., Graaf, R., Gans, R. O. B., Deyneli, O., Ersoz, H. O., Gogas, D., Fak, A. S., Akalin, S., Veglio, M., Sivieri, R., Chinaglia, A., Scaglione, L., Neuropathy Study Group of the Italian Society of the Study of Diabetes, Le, T., Wong, N., Detrano, R., Charles, M. A., Colhoun, H. M., Francis, D. P., Rubens, M., Underwood, S. R., Fuller, J. H., Knudsen, E., Sato, A., Nielsen, F. S., Bonora, E., Kiechl, S., Willeit, J., Oberhollenzer, F., Egger, G., Bonadonna, R., Muggeo, M., Festa, A., D Agostino, R. Jr, Howard, G., Mykkanen, L., Tracy, R. P., Haffner, S. M., Poulsen, P., Vach, K., European Group for the Study of Insulin Resistance (EGIR), Ijzerman, R. G., Bakker, S. J. L., Truster, J., Crowther, N. J., Cameron, N., Gray, I. P., Chaillous, L., Carel, J. C., Thivolet, C., Boitard, C., Charbonnel, B., Sai, P., Study Group, D. I. O. R., Decochez, K., Keymeulen, B., Somers, G., Dorchy, H., Rottiers, R., Winnock, F., Ver Elst, K., Weets, I., Pipeleers, D., Gorus, F., Seebaum, S., Schumm-Draeger, P-M, Petzoldt, R., Federlin, K., Bonnevie-Nielsen, V., Martensen, P. M., Justesen, J., Worsaa, A., Karlsson, Maria, Sederholm, Sofia, Ludvigsson, Johnny, Belicar, P., Dale, C., Vague, Ph, Alessis, C., Lassmann-Vague, V., Bode, B. W., Gross, T. M., Ghegan, M., Steed, R. D., Davidson, P. C., Ordonez, A., Rubio, J. L., Sulleiro, J. M., Buendia, J. P., Zamora, J., Castillo, M., Schaupp, L., Ellmerer, M., Brunner, G. A., Sendlhofer, G., Schlack, Ch, Skrabal, F., Wach, P., Pieber, T. R., Heinemann, L., Kramer, U., Klotzer, H. M., Hermann, M., Non-Invasive Task Force, Cosgrove, K. E., Chapman, J. C., Shepherd, R. M., Mcintyre, S., Butler, P. C., Dunne, M. J., Brekardin, E., Dorschner, H., Schwanstecher, C., Schwanstecher, M., Uhde, I., Emmanouilidou, E., Teschemacher, A. G., Pouli, A. E., Gylfe, E., Tengholm, A., Hellman, B., Perfetti, R., Aggarwal, S., Muller, Gunter, Welte, Stefan, Wied, Susanne, Valverde, A. M., Mur, C., Kahn, C. R., Benito, M., Rondinone, C. M., Peterson, T., Laviola, L., Belsanti, G., Logoluso, F., Napoli, R., Davalli, A. M., Weir, G. C., Giorgino, R., Giorgino, F., Flesch, S., Hompesch, B., Rave, K., Susanto, F., Kuhn-Velten, W. N., Heise, T., Rendell, M., Dole, J., Rosiglitazone Study Group, Esper, R. J., Stein, E., Lemme, L., Cerivastatin/Bezafibrate Latin America Study Group, Rubinstein, A., Maritz, F. J., Soule, S., Market, A., Chajek-Shaul, T., Maislos, M., Tal, S., Stolero, D., Hidm, Investigators, Josefsen, K., Beckmann, H., Petersen, C., Ekman, R., Efanova, I., Zaitsev, S., Berggren, P. O., Birkenbach, M., Holl, R. W., Rosenbauer, J., Grabert, M., German Working Group on Quality Control, Icks, A., Schwab, O., Reile, K., German Pediat. Working Group, Janssen, M. M. J., Jongh, R. T., Casteleijn, S., Masurel, N., Hoogma, R. P. L. M., Santeusanio, F., Brunetti, P., Fanelli, C. G., Laureti, S., Bartocci, L., Maran, A., Crepaldi, C., Trupiani, S., Macdonald, I. A., Avogaro, A., Bouman, S. D., Keitz, M., Bruggink, J. E., Scheurink, A. J. W., Strubbe, J. H., Steffens, A. B., Ferguson, S. C., Mccrimmon, R. J., Perros, P., Best, J. J. K., Deary, I. J., Frier, B. M., Robinson, R. T. C. E., Ireland, N. H., Bedford, C., Fairclough, E., Hudson, S., Heller, S. R., Borch-Johnsen, K., Berger, M., Overmann, H., Bender, R., Blank, M., Sawicki, P., Jorgens, V., Muhlhauser, I., Nosadini, R., Sailer, A., Dalla Vestra, M., Brocco, E., Piarulli, F., Frigato, F., Sambataro, M., Velussi, M., Baggio, B., Fioretto, P., Jager, A., Hinsbergh, V. W. M., Kostense, P. J., Nrjpels, G., Gade, P., Pedersen, O., Andrysiak-Mamos, E., Majkowska, L., Krzyzanowska, B., Pilarska, K., Czekalski, S., Mazzon, C., Brocco, S., Field, L. L., Nejentsev, S., Gombos, Z., Veijola, R., Knip, M., Simell, O., Vaarala, O., Akerblom, H. K., Ilonen, J., Krokowski, M., Bodalski, J., Andrzejewski, W., Lawnik, M., Teodorczyk, A., Heinrich, A., Caillat-Zucman, S., Buzzetti, R., Petrone, A., Mesturino, C., Giorgi, G., Fiori, R., Nistico, L., Di Genova, G., Cascino, I., Kloting, I., Kovacs, P., Mckinney, P. A., Okasha, M., Parslow, R. C., Law, G. R., Gurney, K. A., Williams, R., Bodansky, H. J., Herzig, P., Giani, G., Vervoort, G., Lutterman, J. A., Berden, J. H. M., Wetzels, J. F. M., Paniagua, O., Shaw, L., Austin, C., Heagerty, A. M., Seppala-Lindroos, A., Vehkavaara, S., Yki-Jarvinen, H., Caballero, A. E., Lim, S. C., Logerfo, F. W., Horton, E. S., Zembowicz, A., Fragasso, G., Caumo, A., Phan, V. C., Costa, S., Conti, M., Chierchia, S. L., Vigili Kreutzenberg, S., Marchetto, S., Calo, L., Wascher, T. C., Wolkart, G., Brunner, F., Tripathy, Devjit, Carlsson, Martin, Isomaa, Bo, Tuomi, Tiinamaija, Groop, Leif, Stoffers, D. A., Muller, D. C., Wideman, L., Chin, G. A., Clarke, W. L., Hanks, J. B., Habener, J. F., Guazzarotti, L., Toffolo, G., Clementi, L., Vespasiani, G., Cobelli, C., Clauin, S., Bellanne-Chantelot, C., Bartolotta, E., Gautier, J-F, Wilson, C., Weyer, C., Mort, D., Knowler, W. C., Polonsky, K., Bogardus, C., Pratley, R. E., Veldhuis, J. D., Polonsky, K. S., Byrne, M. M., Brandt, A., Arnold, R., Katschinski, M., Goke, B., Hardt, E., Fritsche, A., Stefan, N., Schutzenauer, S., Luddeke, H. J., Renner, R., Hepp, K. D., Shnawa, N., Krugluger, W., Hopmeier, P., Schernthaner, G., Kautzky-Willer, A., Prager, R., Fallucca, F., Sabbatini, A., Sciullo, E., Torresi, P., Mazziotti, F., Maroccia, E., Napoli, A., Buongiorno, A., Deberg, M., Dozio, N., Castiglioni, M. T., Sodoyez-Goffaux, F., Carvalheiro, M., Fagulha, I., Fagulha, A., Gomes, L., Paiva, S., Marta, E., Sobral, E., Leitao, F., Pinto, L., Ruas, M., Buchanan, T., Di Cianni, G., Volpe, L., Casadidio, I., Bottone, P., Teti, G., Boldrini, A., Benzi, L., Rasera, T., Becciu, V., Beretta, A., Almirante, G., Castiglioni, M., Kerenyi, Zs, Stella, P., Nadasdi, A., Baranyi, E., Csakany, M. Gy, Tamas, Gy, Mehta, Z. M., Manley, S., Zimmett, P., Bottazzo, G. F., Hoey, Hilary, Mollensen, Henrik, Hougaard, Philip, Mcgee, Hanna, Vidal, J., Fernandez, M., Sesmilo, G., Casamitjana, R., Gomis, R., Conget, I., Rathmann, W., Curran, S., Mitchell, J., Hennings, S., Katsaros, T., Saflianis, I., Gigiakou, E., Kasi, E., Polychroniades, V., Dzien, A., Dzien-Bischinger, Ch, Hadjidakis, D., Apostolopoulou, N., Sfakianakis, M., Raptis, A. E., Ryysy, L., Hakkinen, A-M, Goto, T., Westerbacka, J., Halavaara, J., Libman, I., Pietropaolo, M., Laporte, R., Pietropaolo, S., Becker, D., Pirie, F. J., York, D. F., Motala, A. A., Omar, M. A. K., Tzaneva, V., Iotova, V., Jaeger, C., Hatziagelaki, E., Stroedter, A., Becker, F., Bretzel, R. G., Strebelow, M., Schlosser, M., Ziegler, B., Ziegler, M., Wassmuth, R., Ostrauskas, R., Zalinkevicius, R., Norkus, A., Lithuanian Collaborative Group for the Epidemiology of Diabetes, Jarosz-Chobot, P., Otto-Buczkowska, E., Koehler, B., Maklakiewicz, E., Green, A., Ionescu-Tirgoviste, C., Serban, V., Guja, C., Mota, M., Creteanu, G., Calin, A., Morosanu, M., Ferariu, I., Halmagy, I., Cristescu, I., Strugariu, M., Minescu, A., Barbul, R., Visalli, N., Sabastiani, L., Adorisio, E., Cassone Faldetta, M. R., Multari, G., Casu, A., Songini, M., Pozzilli, P., Imdiab, Study Group, Muntoni, Sa, Waananen, S., Law, G., Muntoni, S., Shubnikov, E., Choubnikova, J., Mikulecky, M., Michalkova, D., Hlava, P., Teuscher, A. U., Reinli, K., Teuscher, A., Zhao, H. X., Stenhouse, E., Moyeed, R., Demaine, A. G., Millward, B. A., Feltbower, R. G., Holland, P., Campbell, F., Fear, N. T., Wasmuth, H. E., Elliott, R. B., Mclachlan, C., Erhardt, G., Kolb, H., Guaita, G., Pelligra, I., Motzo, C., Obinu, M., Cossu, E., Cirillo, R., Kinalski, M., Kretowski, A., Bingley, P., Kinalska, I., Douek, I. F., Bingley, P. J., Gale, E. A. M., Imagawa, A., Hanafusa, T., Miyagawa, J., Matsuzawa, Y., Iddm, Osaka Study Group, Todd, J. A., Welsh, K., Marshall, S., Nolsoe, R., Kristiansen, O. P., Larsen, Z., Johannesen, J., Jahromi, M. M., Larsen, Z. M., Kyvik, K. O., Jeanclos, E., Schork, N. J., Aviv, A., Sieradzki, J., Malecki, M. T., Klupa, T., Hanna, L., Sieradzka, J., Frey, J., Krolewski, A. S., Calvo, B., Bilbao, J. R., Perez Nanclares, G., Castano, L., Santos, J. L., Perez-Bravo, F., Piquer, S., Puig-Domingo, M., Carrasco, E., Calvillan, M., Leiva, A., Albala, C., Cavallo, M. G., Manca Bitti, M. L., Suraci, C., Crino, A., Giordano, C., Cervoni, M., Sbriglia, M. S., Bizzarri, C., Marietti, G., Fuchtenbusch, M., Bonifacio, E., Kredel, K., Schnell, O., Ziegler, A. G., Assaad-Khalil, S. H., Michelsen, B. K., El-Azzouni, O., Abou-Seif, M., Kamel, F., Fouad, K., Abdel-Aty, T., El-Sheikh, S., Zamani, Mahdi, Pociot, Hemming, Nerup, Jorn, Cassiman, Jean-Jacques, Olivares, E., Ladriere, L., Laghmich, A., Sener, A., Scott, F. W., Ivanova, O., Poltorack, V., Pramlintide Type 1 Study Group, Pramlintide Type 2 Study Group, Gorbenko, N., Gladkich, A., Nikitchenko, I., Dunger, A., Augstein, P., Berg, S., Williams, A. J. K., Norcross, A. J., Gillmor, H. A., Lampasona, V., Bernasconi, L., Hermite, L., Martin-Moutot, N., Boucraut, J., Seagar, M., Couraud, F., Scirpoli, M., Maioli, M., Tonolo, G., Bekris, L., Schranz, D., Ciccarese, M., Lernmark, A., Lee, H. C., Nam, J. H., Ahn, C. W., Song, Y. D., Lim, S. K., Kim, K. R., Huh, K. B., Fajardo, C., Carmona, E., Sanchez-Cuenca, J. M., Campos, V., Carles, C., Brazales, A., Merino, F., Pinon, F., Masek, Z., Perusicova, J., Barova, H., Sterzl, I., Hejdukova, H., Schneiderka, P., Hink, S., Muzyka, B., Streit, G., Kopp, H. P., Kroiss, A., Tankova, T., Dakovska, L., Kirilov, G., Koev, D., Abrams, P., Block, C., Rooman, R., Du Caju, M., Eibl, N. L., Wolf, H., Eibl, M. M., Di Cesare, E., Previti, M., Lombardo, F., Di Benedetto, A., Romano, G., Luca, F., Cucinotta, D., Brunelle, R. L., Huang, J., Fineberg, S. E., Anderson, J. H., List, C., Lamesch, P., Kohlhaw, K., Schwarz, C., Wenzke, M., Richter, O., Hauss, J., Zeng, S. F., Xu, X. S., Zheng, S. X., Shii, K., Baba, S., Bonfanti, R., Bazzigaluppi, E., Meschi, F., Bognetti, E., Bosi, E., Chiumello, G., Cinapri, V., Quilici, S., Forotti, G., Giampietro, O., Matteucci, E., Luppi, P., Zanone, M. M., Rudert, W., Haluszczak, C., Alexander, A., Bertera, S., Gottlieb, P., Trucco, M., Irnstetter, A., Jager, G., Schenker, M., Ziegler, M. A. G., Mysliwiec, J., Szelachowska, M., Monetini, L., Valente, L., Coppolino, G., Stefanini, L., Corbi, S., Spera, S., Matteoli, M. C., Ferrazzoli, F., Cantagallo, A., Mattia, G. C., Walker, B., Sonnet, E., Gibassier, J., Derrien, C., Massart, C., Allannic, H., Maugendre, D., Leech, N. J., Elsegood, K. A., Narendran, P., Hubbard, A., Dayan, C. M., Mianowska, B., Bodalska-Lipinska, J., Chrul, S., Wyka, K., Geissler, A., Schneider, M. L., Bochow, B., Koop, I., Zhang, T. M., Zhang, Y., Han, C. H., Jin, S. X., Dervogormiyaciyan, H., Arasli, M., Aydemir, D., Yillar, G., Deniz, G., Gurol, A. O., Aktas, E., Tutuncu, Y., Pertynska, M. P., Banasik, M., Zeman, K., Cypryk, K., Wilczynski, J., Tchorzewski, H., Muser, E. S., Baier, J. E., Bergbauer, M., Schmutz, G., Figge, A., Reiser, M., Schmiegel, W., Burkart, V., Kim, Y-E, Kauer, M., Utsugi, T., Kanda, T., Kobayashi, I., Uchiyama, T., Ito, H., Ohyama, Y., Tomono, S., Kawazu, S., Nagai, R., Hehmke, B., Heinke, P., Kelemen, K., Wegmann, D., Hutton, J. C., Wachlin, G., Schroder, D., Schmidt, S., Schloot, N. C., Hanifi-Moghaddam, P., Goebel, C., Rothe, H., Hausmann, A., Laureys, J., Depovere, J., Waer, M., Karsten, V., Tritschler, S., Belcourt, A., Pinget, M., Kessler, L., Gregori, S., Sala, L., Smiroldo, S., Davalli, A., Adorini, L., Bo, S., Repetti, E., Gentile, L., Fornengo, P., Bruno, A., Ferrero, L., Kanoun, F., Harzallah, F., Ftouhi, B., Mekaouar, A., Bellaaj, R., Fekih, M., Mebazaa, A., Zouari, B., Ben Khalifa, F., Turkish Diabetes Epidemiology Group, Spijkerman, A. M. W., Ruige, J. B., Colagiuri, S., Colagiuri, R., Palu, T., Na Ati, E., Muimui-Heata, S., Samiu, O., Deblieck, C., Ta Ai, A., Foliaki, S., Hussain, Z., Mclennan, M., Hansen, C. N., Ibsen, H., Dogadin, S. A., Nozdratchev, K. G., Lidfeldt, J., Nerbrand, C., Lindholm, L. H., Samsioe, G., Schersten, B., Agardh, C-D, Wojcikowski, Cz, Grzeszczak, W., Lopatynski, J., Bandurska-Stankiewicz, E., Screen-Pol Study Group, Mardarowicz, G., Krol, H., Matej, A., Czupryniak, L., Kropiwnicka, A., Drzewoski, J., Viljoen, E., Costa, A., Martinez, S., Carmona, F., Levy, I., Baruffaldi, L., Solerte, B., Mantovani, E., Boullu, S., Jeandidier, N., Legaludec, V., Costa, B., Franch, J., Martin, F., Morato, J., Donado, A., Basora, J., Daniel, J., Igt, Research Group, Sayeed, M. A., Mahtab, H., Kibriya, M. G., Khanam, P. A., Azad Khan, A. K., Courten, M., Chitson, P., Cox, H., Ncd, Mauritian Group, King, R., Dachtler, J., Johnston, D., Ito, C., Kataoka, M., Lakhdar, A. A., Myers, M. A., Fuecker, K., Echwald, S. M., Hansen, T., Ekstrom, C. T., Urhammer, S. A., Eiberg, H., Roberts, S., Barrow, B. A., Hainsworth, J., Schousboe, K., Henriksenog, J. E., Sorensen, T. I. A., Herlihy, O. M., Timmer, B., Grant, P. J., Bennett, S. M. A., Ghunaim, S. A., Stewart, M. W., Baroni, M. G., Sentinelli, F., Lovari, S., Vitali, M., Capici, F., Barbetti, F., Weng, J. P., Lehto, M., Li, H., Forsblom, C., Groop, L., Blanche, H., Morel, V., Hansen, L., Stanojevic, V., Petersen, H. V., Urioste, S., Stoffers, D., Moller, A. M., Serup, P., Ek, J., Durviaux, S., Clausen, J. O., Rousseau, G. G., Lemaigre, F. P., Bjorkhaug, L., Njolstad, P. R., Lindner, T., Cockburn, B. N., Molven, A., Sovik, O., Lindner, T. H., Horikawa, Y., Frederiksen, S. K., Almind, K., Obberghen, E., Den Brandt, J., Fenger, M., Vaag, A., Haist, K., Weisser, M., Rettig, A., Zhang, M., Chung, S. S. M., Pihlajamaki, J., Karjalainen, L., Karhapaa, P., Vauhkonen, I., Cassell, P., Uwakwe, N., Kopelman, P., Ramachandran, A., Snehalatha, C., Rasmussen, S. K., Lautier, C., Grigorescu, F., Smith, R. J., Frayling, T., Turner, R., Hitman, G., Subba Rao, P., Bennett, A. J., Jones, E., Lathrop, G. M., Menzel, S., Wahid, F., Cooper, L., Scott, J., Aitman, T. J., Galli, J., Fakhrai-Rad, H., Kamel, A., Marcus, C., Norgren, S., Luthman, H., Wallis, R. H., Collins, S. C., Kaisaki, P. J., Ktorza, A., Lathrop, M., Gauguier, D., Huxtable, S., Mccarthy, M., Shimomura, H., Hanabusa, T., Tsunoda, K., Lazdins, M., Dalgaard, L. T., Jensen, N. M., Jensen, J. N., Lynn, S., Turnbull, D. M., Gaztambide, S., Vazquez, J. A., Groves, C. J., Izmajlowicz, M. L., Horton, V. A., Owen, R. J., Stratton, I. R., Green, F. R., Groves, C., Horton, V., Owen, R., Stratton, I., Clark, L. A., Voigt, A., Rochlitz, H., Rau, H., Braun, J., Schmidt, K., Plock, K., Donner, H., Schoneberger, A., Usadel, K. H., Badenhoop, K., Bendlova, B., Mazura, I., Vcelak, J., Vondra, K., Palyzova, D., Svatos, J., Miksova, P., Russo, G., Couture, P., Wilson, P. W. F., Cupples, L. A., Otvos, J. D., Schaefer, E. J., Ordovas, J. M., Ji, L., Curtis, S., Rich, S. S., Warram, J. H., Gudayol, M., Usac, E. F., Essen, E. H. R., Roep, B. O., T Hart, L. M., Janssen, J. J., Den Ouweland, J. M. W., Lemkes, H. H. P. J., Maassen, A. J., Nakano, S., Fukuda, M., Maejima, K., Imaizumi, N., Kitazawa, M., Nishizawa, M., Kigoshi, T., Uchida, K., Le Gall, J. Y., David, V., Baltrusch, S., Richter, T., Da Silva Xavier, G., Dickens, M., Belin, V. D., Green, I. C., Burns, C. J., Squires, P. E., Howell, S. L., Persaud, S. J., Ban, N., Yamada, Y., Someya, Y., Ihara, Y., Tsuda, K., Seino, Y., Alcazar, O., Tyrberg, B., Carlsson, C., Andersson, A., Mukai, E., Ishida, H., Fujimoto, S., Kajikawa, M., Fujita, J., Tsuura, Y., Malaisse-Lagae, F., Picton, S., Tamarit-Rodriguez, J., Mukala-Nsengu-Tshibangu, A., Fernandez, S., Gine, E., Ortsater, H., Liss, P., Akerman, K. E. O., Bergsten, P., Hu, S., Wang, S., Roos, E. S., Gounarides, J. S., Shapiro, M. J., Souza, C. J., Papas, K. K., Nishimura, M., Kadiata, M. M., Louchami, K., Jijakli, H., Rajan, A. S., Kuang, S., Iyer, D., Waddell, I. D., Holloway, B. R., Ishihara, H., Wang, H., Wollheim, C. B., Ayvaz, G., Mercan, D., Rasschaert, J., Giroix, M-H, Scruel, O., Portha, B., Broca, C., Fernandez-Alvarez, J., Manteghetti, M., Gross, R., Sauvaire, Y., Petit, P., Ribes, G., Mcclenaghan, N. H., Ball, A. J., Flatt, P. R., Rustenbeck, I., Dickel, C., Winkler, M., Grimmsmann, T., Meyer, U., Gross, I., Barnes, P. D., O Brien, R. E., Abdel-Wahab, Y. H. A., Hashmi, M. N., Giesberts, A. N., White, S. J., Cooper, E. J., Hudson, A. L., Eglen, R. M., Dillon, M. P., Chan, S. L. F., Morgan, N. G., Parini, A., Gotfredsen, C., Ullrich, S., Su, J., Rosier, M., Hescheler, J., Greger, R., Wardt, R., Arredouani, A., Gailly, P., Henquin, J. C., Gilon, P., Macfarlane, W. N., Docherty, K., Jonkers, F. C., Schofl, C., Borger, J., Zur Muhlen, A., Brabant, G., Grapengiesser, E., Harris, T. E., Buchan, A. M. J., Jones, P. M., Jaikaran, E. T. A. S., Marcon, G., St George-Hyslop, P. H., Fraser, P. E., Clark, A., Lebrun, P., Antoine, M-H, Nguyen, Q-A, Rorsman, Patrik, Wasmeier, C., Antinozzi, P., Maechler, P., Schwartz, E., Wollheim, C., Roderigo, H. M., Matsumoto, K., Ebihara, K., Yamamoto, H., Tabuchi, H., Fukunaga, K., Yasunami, M., Ohkubo, H., Miyamoto, E., Horn, P. A., Maria Jose Garcia Barrado, Sancho, C., Martin, M., Moratinos, J., Westerlund, J., Lin, J. M., Brown, R., Bjorklund, A., Grill, V., Detimary, P., Guiot, Y., Rahier, J., Elmi, A., Sehlin, J., Hauge-Evans, A. C., Cybal, M., Druzynska, J., Wierzchowska, J., Krippeit-Drews, P., Drews, G., Kramer, C., Jornot, L., Dufer, M., Noda, M., Yamashita, S., Takahashi, N., Tsubamoto, Y., Kasai, H., Sharp, G. W. G., Lembert, N., Joos, H. C., Ammon, H. P. T., Wahl, M. A., Ainscow, E. K., Zhao, C., Fabregat, M. E., Franco, C., Novelli, M., Masiello, P., Lajoix, A., Beffy, P., Roux, S., Chardes, T., Roye, M., Lajoix, A. D., Reggio, H., Peraldi-Roux, S., Henningsson, R., Salehi, A., Lundquist, I., Stickings, P., Mistry, S., Ratcliff, H., Morris, S. M. Jr, Cunningham, J. M., Ekelund, M., Ermakova, N. V., Paulssen, R. H., Florholmen, J., Carmellini, M., Mosca, F., Longo, D., Squatrito, S., Clement, L., Magnan, C., Vincent, M., Penicaud, L., Assimacopoulos-Jeannet, F., Vigneri, R., Rolfsen, S. E. D., Gregersen, S., Hermansen, K., Blondeau, B., Rojas, I., Novials, A., Femandez-Usac, E., Cristobal, P., Higham, C. E., Lawrie, L., Sherman, K. I. J., Birch, N., Tito, P., Robinson, C. V., Koning, E. J. P., Verbeek, J. S., Esapa, C., Laube, B., Powell, D. S., Maksoud, H., Charge, S. B. P., Matthews, D. R., Stratton, I. M., Karlsson, S., Myrsen-Axcrona, U., Ostlund, B., Sundler, F., Bertrand, G., Puech, R., Bockaert, J., Persson-Sjogren, S., Taljedal, I-B, Mooney, M. H., O Harte, F. P. M., Simonsson, E., Abdel-Halim, Samy M., Yanagida, K., Arima, T., Yada, T., Egea, J. C., Hirtz, C., Deville Periere, D., Meoni, C., Falqui, L., Arcelloni, C., Paroni, R., Folli, F., Barry, R., Turner, N. C., Tadayyon, M., Arch, J. R., Sutti, F., Perego, L., Baglioni, S., Otte, A., Socci, C., Raffaele, H. S., Stumpf, E., Aalto, Y., Otonkoski, T., Knuutila, S., Andersson, L. C., Berra, C., Furlan, R., Coppelli, A., Tellini, C., Bordignon, C., Rouiller, D. G., Lister, C. A., Moore, G. B. T., Piercy, V., Newman, M., Chapman, H., Smith, S. A., Anastasi, E., Bulotta, A., Tiberti, C., Ponte, E., Liddi, R., Taruscio, D., Falchi, M., Anneren, C., Welsh, M., Bernard, C., Ilic, C., Guilbert, V., Palgi, J., Korbutt, G. S., Rayat, G. R., Rajotte, R. V., Kieffer, T. J., Karlsson, Ella, Sandler, Stellan, Boujendar, S., Huotari, M-A, Miettinen, P. J., Keski-Oja, J., Breda, E., Pacini, G., Vilsboll, T., Toft-Nielsen, M-B, Dinesen, B., Corssmit, E. P. M., Qvigstad, E., Mostad, I. L., Bjerve, K., Ann, C. W., Kume, M., Hiramatsu, M., Taniguchi, J., Saito, Y., Kawasaki, Y., Kanazawa, M., Notoya, Y., Hayashi, T., Djemli, A., Gallice, P., Coste, T., Jannot, M. F., Dufayet, D., Raccah, D., Vague, P., Sattar, S., Basak, R. C., Hasan, Z., Ali, L., Nikulina, M. A., Karlsen, A. E., Hong, T. P., Andersen, N. A., Puren, A. J., Fantuzzi, G., Dinarello, C. A., Gysemans, C. A., Sparre, T., Fey, S., Larsen, P. M., Andersson, A. K., John, N. E., Fey, S. J., Mose Larsen, P., Frigerio, S., Ghayur, T., Hollander, G. A., Zumsteg, U., Pinach, S., Monge, L., Grassi, G., Pasquero, P., Ruiu, G., Dall Omo, A., Carta, Q., Hadjivassiliou, V., Dunger, A. M., Green, M. H. L., Rasilainen, S., Roivainen, M., Ylipaasto, P., Bouwens, L., Hovi, T., Sekine, N., Takahashi, K., Ishikawa, T., Okazaki, T., Fujita, T., Elliott, J., Scarpello, J. H. B., Conroy, S., Byrne, P., Newsholme, P., Harrison, M., Greenl, I. 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J., Quinones Galvan, A., Simeoni, M., Basu, A., Uosukainen, A., Makimattila, S., Schlenzka, A., Adler, A. I., Levy, J., Stevens, R., Matthews, D., Holman, R., Boland, B. J., Jeanjean, M., Hermans, M. P., Maudoigt, C., Tonglet, R., Robert, A., Cini, G., Galetta, F., Sanna, G., Gernone, F., Janssen, M. J., Gonera, R. K., Wolffenbuttel, B. H. R., Leeuw, P. W., Schaper, N. C., Moleda, P., Kuczerowski, R., Czech, A., Taton, J., Taddei, S., Patiag, D., Qu, X., Wilkes, M., Gray, S., Seale, J. P., Donnelly, R., Campion, J., Maestro, B., Davila, N., Carranza, M. C., Calle, C., Hales, C. N., Fernandez-Real, J. M., Grasa, M., Pugeat, M., Barret, C., Ricart, W., Lindmark, S., Olsson, T., Tufvesson, M., Loeblein, K., Mehnert, B., Haering, H. 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S., Murphy, L., Rodger, N. W., Ross, S. A., Ryan, E., Yale, J-F, Wolever, T. M. S., Haller, T., Elias, I., Segal, P., Standi, E., Rybka, J., Sencer, E., Schlcnzka, A., Vakkilainen, J., Tsaglis, H., Ioannidis, I., Giakoumaki, A., Amantou, A., Komitopoulos, N., Georgiou, S., Varsamis, E., Katsilambros, N., El Gayar, M., Shereba, N., Botros, R., Fikry, R., Jackson, D., Balme, M., Silva-Nunes, J., Alves, J., Bogalho, P., Gardete-Correia, L., Nunes-Correa, J., Kot Atkova, A., Nemcova, D., Vrbikova, J., Zamrazil, V., Meyer, L., Delbachian, I., Lehert, P., Cugnardey, N., Drouin, P., Guerci, B., Wagner, O. F., Jones, N. P., Vallance, S. E., Thompson, K. A., Miller, A. K., Inglis, A. M. L., Patterson, S., Jorkasky, D., Freed, M. I., Mathisen, A. L., Schneider, R., Rubin, C., Houser, V., Beebe, K. L., Kortboyer, J. M., Eckland, D. J. 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E., Niekerk, N., Rosenkranz, B., Schoenle, E., Hoe, Study Group, Witthaus, Elke, Bradley, Clare, Stewart, John, Barbeau, M., Myers, S., Flora, D., Dimarchi, R., Chance, R., Plum, A., Larsen, P. S., Larsen, U. D., Kristensen, J. B., Jansen, J. A., Olsen, B., Mortensen, H., Hylleberg, B., Jacobsen, L. V., Gall, M-A, Sogaard, B., Ewing, F. M., Ireland, R. H., Hoogwerf, B., Raskin, P., Jovanovic, L., Leiter, L., Boss, A. H., Bott, U., Ebrahim, S., Hirschberger, S., Leukel, P., Sieber, H. J., Mcgill, J., Kilo, C., Kamp, N. M., Wutte, A., Le Thai, F., Balarac, N., Allicar, M. P., Cazeneuve, B., Augendre, B., Wise, S. D., Seah, E. S., Koivisto, V., Torlone, E., Del Sindaco, P., Ciofetta, M., Hedman, C., Orre Pettersson, A-C, Lindstrom, T., Cernigoi, A. M., Kong, N., Kitchen, M. M., Ryder, R. E. J., Petkova, M., Angelova-Gateva, P., Malone, J., Arora, V., Bue-Valleskey, J., Pein, M., Diebler, F., Roach, P., Gudat, U., Dreyer, M., Hanusch, U., Ristic, S., Mcleod, J., Hirschberg, Y., Garreffa, S., Keilson, L., Mather, S., Gagen, K., Chen, W., Dragonas, N., Chuang, L. M., Juang, J. H., Wu, H. P., Chiang, Y. D., Li, K. L., Jorgensen, L. N., Tai, T. Y., Cheatham, W. W., Kennedy, F., Woo, V., Jain, R., Boss, A., Moses, R., Clauson, P., Fischer, T., Bjork, S., Ostergaard, A., Langendorf, K. W., Hatorp, V., Hasslacher, C., Farrar, N. S., Chambers, N. J., Denyer, G. S., Johnston, G. A. R., Hashiguchi, S., Jonsson, A., Hallengren, B., Rydberg, T., Herbaut, C., Turc, A., Mourand, I., Chevassus, H., Molinier, N., Christensen, A-B L., Mathiesen, E. R., Stage, E., Damm, P., Boivin, S., Gross, P., Pennington, M., Harder, T., Kohlhoff, R., Dorner, G., Rohde, W., Plagemann, A., Ferdeghini, M., Murru, S., Maffei, M., Cecchetti, P., Dunne, F., Brydon, P., Smith, T., Proffitt, M., Holder, R., Gee, H., Goulis, D. G., Teoh, T. G., Asatiani, N., Elphick, A., Natsvlishvili, M., Chanturia, T., Shelestova, E., Ramazashvili, M., Hod, M., Cederberg, J., Casi, A. Leunda, Pampfer, S., Hertogh, R., Hinck, L., Aly, S., Bertie, J., Botta, R. M., Imbergamo, M. P., Impicciche, M. G., Todaro, B., Greco, D., Ekbom, P., Clausen, P., Feldt-Rasmussen, U., Feldt-Rasmussen, B., Molsted Pedersen, L., Norgaard, K., Svenningsen, A., Nielsen, L., Zmudzinska, M., Zietek, I., Min, Y., Crawford, M. A., Bozzoni, F., Corubolo, C., Borrello, E., Di Biase, N., Spagnolo, S., Hawthorne, G., Sen, D., Bagust, A., Northern Diabetic Pregnancy Survey, Maier, W., Currie, C. J., Sailesh, S., Patel, V., Hayes, D., Cockrill, B., Gatling, W., Budd, S., Mullee, M. A., Savill, A. W., Smithers, M. G., Davies, R. R., Sandford, A., Stutz, L., Vadstrup, S., Simonsen, V., Musaeus, L., Molsing, B., Lyholm, B., Turner, B. C., Jenkins, E., Hejlesen, O. J., Andreassen, S., Hovorka, R., Cavan, D. A., Klinge, A., Strauss, K. W., Guthrie, R., Testa, M., Zimmerman, R., Sandberg, M., Steinfatt, H., Hardenberg, R., Gottsmann, M., Konig, A., Schmauss, S., Hierl, F. X., Renders, C. M., Valk, G. D., Eijk, J. Th M., Wal, G., Jermendy, G., Hidvegi, T., Screening Study Group, Hungarian Hba C., Muller, U. A., Junghanel, J., Kohler, S., Kohler, C., Schumann, M., Use, G., Valk, H. W., Blankestijn, J. G., Bruin, H. J., Bottomley, J., Gillam, S., Holmes, J., Murphy, M., Tardis Uk, Steering Committee And Centres, Madani, S. F., Muller, R., Hunger Dathe, W., Grusser, M., Roien, D., Hussain, M., Vibe-Petersen, J., Braun, A., Schiel, R., Hofer, A., Leppert, K., Trento, M., Passera, P., Tomalino, M., Bajardi, M., Vaccari, P., Pagnozzi, F., Pomero, F., Molinatti, G. M., Porta, M., Blaauwwiekel, E. E., Hania, M., Scholten-Jaegers, S. M. H. J., Links, T. P., Perciun, R., Dumitrescu, C., Skeie, S., Thue, G., Sandberg, S., Nordfeldt, S., Ludvigsson, J., Garcia, Rosario, Suarez, Rolando, Henry, J. L., Kangas, M., Wilson, P. H., Pibernik, M., Szabo, S., Metelko, Z., Gonzalez-Clemente, J. M., Galdon, G., Pedro, B., Fontanals, Ll, Minarro, A., Topsever, P., Azik, A., Dundar, Y., Sengul, A., Vileikyte, L., Apostolou, T., Tomenson, B., Bundy, C. H., Gokal, R., Gormley, D. A., Who Idf, Patient Empowerment Workshop, Baksi, A. K., Hrachovinova, T., Csemy, L., Bartaskova, D., Krch, F. D., Gafvels, M. C., Lithner, F., Branchtein, L., Matos, M. C. G., Gaio, D., Yamashita, T., Pousada, J. M. D. C., Duncan, B. B., Schmidt, M. I., Brazilian Gestational Diabetes Study Group, Buchanan, T. A., Xiang, A. H., Tan, S., Peters, R. K., Trigo, E., Kjos, S. L., Lee, W. P., Azen, S., Ilic, S., Mezic, J., Pettitt, D. J., Bastyr, E. J., Camps, I., Salcedo, M. D., Rius, F., Rubio, M., Baptista, C., Martins, T., Ruas, M. M. A., Acosta, D., Cerrillos, L., Soto, A., Quijada, D., Morales, F., Silva, H., Garcia-Hernandez, N., Villamil, F., Astorga, R., Selby, P. L., Jude, E. B., Biggs, A. M., Al-Sabbagh, S., Kumar, S., Rowbotham, J., Mckenzie, W. E., Dodson, P. M., Barnett, A. H., Maresh, M., Alevizaki, M., Anastasiou, E., Grigorakis, S. I., Philippou, G., Michalopoulou, G., Souvatzoglou, A., Corcoy, R., Pau, E., Pascual, E., Garcia-Patterson, A., Albareda, M. L., Ccrmeno, J., Altirriba, O., Adelantado, J. M., Ubeda, J., Endocrinologia, S., Reichelt, A. J., Nucci, L., Teixeira, M. M., Costa-E-Forti, A., Ciampalini, P., Giannone, G., Benedetti, S., Borrelli, P., Czerniawska, M., Manowska, B., Rami, B., Schober, E., Hueppe, A., Granditsch, G., Huber, W., Bittmann, B., Jaeger, A., Saukkonen, T., Vaisanen, S., Savilahti, E., Childhood Diabetes in Finland Study Group, Sumnik, Z., Kotalova, R., Loudova, M., Cinek, O., Snajderova, M., Kolouskova, S., Vavrinec, J., Barbato, M., Viola, T., Formisano, M., Hovind, P., Adler, I. A., Uk, Prospective Diabetes Study Group, Makita, Z., Takeuchi, M., Kamada, Y., Koike, T., Courreges, J. P., Pradier, P., Bacha, J., Aboud, E., Andre, L., Lamarca, R., Service of internal medecine - diabetologia - vascular diseases, Janeczko-Sosnowska, E., Lewandowski, Z., Janeczko, D., Kopczynski, J., Nakagami, T., Tomonaga, O., Babazono, T., Iwamoto, Y., Nakanishi, K., Higa, M., Kosugi, E., Elving, L. D., Szadkowska, A., Mirecka, M. W., Czerniawska, E., Weekers, L., Hadjadj, S., Belloum, R., Gallois, Y., Bouhanick, B., Marre, M., Saucha, W., Skwarna, B., Zychma, M., Zukowska-Szczechowska, E., Zychma, M. J., Nazim, J., Dziatkowiak, H., Sanak, M., Cieslik, G., Nannipieri, M., Viberti, G. C., Cosmo, S., Piras, G., Errannini, E., Uchigata, Y., Miura, J., Okada, T., Gong, J-S, Zhang, J., Tanaka, M., Wamoto, Y., Zucaro, L., Bacci, S., Miscio, G., Thomas, M., Piras, G. P., Cavallo Perin, P., Mauer, M., Barzon, I., Bortoloso, E., Saller, A., Crepaldi, G., Latif, Z. A., Christensen, P. K., V Larsen, S., Olsen, S., Bombonato, G., Sacerdoti, D., Chiesura-Corona, M., Marangon, A., Rudberg, S., Rasmussen, L., Bangstad, H-J, Osrterby, R., Sivous, G. I., Kasatkina, E. P., Demurov, L. M., Nosikov, V. V., Kotova, A. K., Kuraeva, T. L., Mishina, I. I., Gorashko, N. M., Nosicov, V. V., Petercova, V. A., Berrut, G., Alhenc-Gelas, F., Tsimaratos, M., Gerbi, A., Barone, R., Ollerton, R. L., Playle, R. A., Luzio, S. D., Evans, W. D., Burch, A., Siebenhofer, A., Meinitzer, A., Brandmaier, H., Brunner, G., Plank, J., West, P., Tindall, H., Mckenna, K., Smith, D., Tormey, W., Kesson, C. M., Thompson, C. J., Penno, G., Anichini, R., Bandinelli, S., Boldrini, E., Giannarelli, R., Piazza, F., Pucci, L., Karunakaran, S., Morris, R. J., Nadas, J., Farkas, K., Daroczy, A., Peterfai, E., Svensson, M., Weigert, C., Facchin, S., Gambaro, G., Brodbeck, K., Schleicher, E., Tada, H., Nomura, K., Kuboki, K., Tsukamoto, M., Inokuchi, T., Mene, P., Pugliese, F., Iino, K., Yoshinari, M., Iwase, M., Asano, T., Sonoki, K., Wakisaka, M., Takata, Y., Ujishima, M., Del Prete, D., Anglani, F., Antonucci, F., Mauri, J. M., Valles, M., Vendrell, J., Shinada, M., Akdeniz, A., Panagiotopoulos, P., Bach, L. A., Law, V. A., Lecomte, P. P., Yokota, C., Okuda, Y., Odawara, M., Yamashita, K., Yamada, N., Kawai, K., Acbay, O., Mazlum, A., Kural, E., Gundogdu, S., Jensen, C., Korner, A., Eklof, A-Ch, Jaremko, G., Lal, M., Dibona, G., Aperia, A., Yavuz, D. G., Tuncer, M., Sargon, M., Kucukkaya, B., Ahiskali, R., Akalin, Sema, Nohara, E., Oates, P. J., Ellery, C. A., Cakyr, B., Erdogan, M. F., Corakcy, A., Ozdemir, I. C., Stevens, R. J., Yudkin, J. S., Webber, J., Wheeler, D. C., Taylor, K. G., Jones, S. L., Srivatsa, A., Anderson, S. G., Cruikshank, J. K., Florkowski, C. M., Scott, R. S., Graham, P. J., Moir, C. L., Flores, C., Ruggenenti, P., Dodesini, A. R., Vasile, B., Gaspari, F., Arnoldi, F., Ferrari, S., Ciocca, I., Spalluzzi, A., Remuzzi, G., Delvigne, C., Ballaux, D., Bosman, D. R., Winkler, A. S., Marsden, J., Watkins, P. J., Strutton, D., Erbey, J. R., Jacobsen, P., Rossing, K., Jensen, J. S., Mansfield, M. W., Kowalska, I., Telejko, B., Bachorzewska-Gajewska, A., Prokop, J., Kochman, W., Musial, W., Naskret, D., Oleksa, R., Zozulinska, D., Sowinski, J., Wierusz-Wysocka, B., Klamann, A., Jonas, M., Muller-Lung, U., Heuser, L., Launhardt, V., Valensi, P., Paries, J., Torremocha, F., Brulport, V., Sachs, R. N., Vanzetto, G., Levy, M., Lormeau, B., Halimi, S., Perfornis, A., Boumal, D., Zimmermann, C., Bernard, Y., Sabbah, A., Meneveau, N., Gautier, S., Bassand, J. P., Andel, M., Kraml, P., Potockova, J., Dvorakova, H., Treslova, L., Nuttall, S. L., Martin, U., Kendall, M. J., Schiaffini, R., Pantaleo, A., Battocletti, T., Vaccari, V., Brufani, C., Martuscelli, E., Gargiulo, P., Nieszner, E., Posa, I., Kocsis, E., Preda, I., Pogatsa, G., Koltai, M. Z. S., Stefanidis, A., Manoussakis, S., Handanis, S., Zairis, M., Vitalis, D., Dadiotis, L., Fiorina, P., La Rocca, E., Astorri, E., Rossetti, C., Lucignani, G., Giudici, D., Castoldi, R., Mazarakis, N., Giagiakou, E., Karavidas, A., Agellou, A., Karamani, O., Matsakas, E., Caviezel, F., Morricone, L., Ranucci, M., Denti, S., Cazzaniga, A., Enrini, R., Isgro, G., Gonzalez Molina, F. J., Sala, J., Masia, R., Marrugat, J., Kruszewski, P., Wolnik, B., Bieniaszewski, L., Swierblewska, E., Semetkowska-Jurkiewicz, E., Krupa-Wojciechowska, B., Vasilikos, P. G., Alaveras, A. E. G., Anastasopoulos, N. G., Chala, E., Sidira, M., Christakopoulos, P. D., Poulsen, P. L., Hansen, K. W., Ebbehoj, E., Knudsen, S. T., Mogensen, C. E., Ramu, Y., Vidyullatha, Y., Strojek, K., Gorska, J., Morawin, E., Ritz, E., Ciavarella, A., Malini, P. L., Strocchi, E., Fiumi, N., Ambrosioni, E., Idzior-Walus, B., Stevens, L., Mceneny, J., O Kane, M. J., Moles, K. W., Mcmaster, C., Young, I. S., Leonhardt, W., Konstadelou, E., Gurlek, Alper, Soedamah-Muthu, S., Taskinen, M. R., Ehnholm, C., Wagner, A., Bayen, Laia, Rigla, M., Ortega, E., Caixas, A., Mestron, A., Ordonez, J., Perez, A., Sotiropoulou, G., Servais, P. L., Bertolotto, A., Pilo, M., Suchankova, G., Andratschke, S., Tschop, M., Strasburger, C-J, Rizzo, L., Aerts, P., Vinckx, M., Ansquer, J. C., Ryan, M., Buter, H., Navis, G. J., Jong, P. E., Zeeuw, D., Carreras, G., Gimenez, G., Pou, J. M., Howorka, K., Gabriel, M., Pumprla, J., Koves, A., Bhowmik, N. B., Haque, A., Rahman, A., Paleari, F., Gamba, P., Mauri, G., Rovaris, G., Giannattasio, C., Piatti, M. L., Zincone, A., Cavaletti, G., Mancia, G., Lan, S., Arezzo, J., Gerber, R. A., Klioze, S. S., Saponara, C., Tartaglione, T., Cercone, S., Caputo, S., Meloni, T., Brunetti, D., Di Lazzaro, V., Xu, G., Jiang, H. Y., Shy, M. E., Sugimoto, K., Zhang, W-X, Kuchmerovskaya, T., Donchenko, G., Shymansky, I., Kuchmerovsky, N., Pakyrbaeva, L., Cameron, N. E., Keegan, A., Cotter, M. A., Mirrlees, D., Smale, S. E., Biessels, G. J., Duis, S. E. J., Kamal, A., Gispen, W. H., Carrington, A., Carman, S., Smiarowski, H., Lavoie, D., Sawicki, D., Sabetta, A., Litchfield, J., Zandt, M., Sredy, J., Smirnova, V., Strokov, I., Ivanova, L., Ichunina, A., Nakamura, J., Nakayama, M., Hamada, Y., Chaya, S., Kato, K., Kasuya, Y., Mizubayashi, R., Miwa, K., Yasuda, Y., Kamiya, H., Hotta, N., Biro, K., Kukorelli, T., Szilagyi, N., Kurthy, M., Komaromy, A., Mogyorosi, T., Nagy, K., Cakir, M., Baskal, N., Gullu, S., Elhan, A. H., Erdogan, G., Ziegler, D., Piolot, R., Neubauer, J., Senesi, B., Bonetti, R., Napolitano, A., Canepa, F., Ottonello, P., Schabmann, A., Gimenez-Perez, G., Arroyo, J. A., Lopez, T., Ponz, E., Mauricio, D., Diem, P., Zanchin, L., Suter, S. L., Lefrandt, J. D., Smit, A., Roon, A. M., Dullaart, R., Voita, D., Mackevics, V., Vitols, A., Lengyel, Cs, Farkas, Gy, Torok, T., Legrady, P., Varkonyi, T. T., Kardos, A., Gingl, Z., Kempler, P., Rudas, L., Lonovics, J., Marchand, M., Stevens, L. K., Tarnas, Gy, Eurodiab Iddm, Study Group, Estrella, F., Christensen, N. J., Keresztes, K., Barna, I., Hermanyi, Zs, Vargha, P., Bonnevie, L., Chanudet, X., Larroque, P., Tutuncu, N. Bascil, Deger, A., Batur, M. K., Yildirir, A., Onalan, O., Aksoyek, S., Kabakciota, G., Erbas, T., Galicka-Latala, D., Surdacki, A., Gerritsen, J., Tenvoorde, B. J., Heethaar, R. M., Tagawa, T. S., Kodama, M., Yoshioka, R., Yamasaki, Y., Didangelos, T., Athyros, V., Kontopoulos, A., Papageorgiou, A., Karamitsos, D., Lacigova, S., Rusavy, Z., Karova, R., Perrild, H., Kay, L., Jorgensen, T., Bien, A. I., Witek, P., Geraldes, Elizabete, Rodrigues, D., Pereira, L., Domenech, A., Leitao, P., Anagnostopoulos, D., Foster, A. V. M., Nag, S., Barsoum, M., Lewis, G., Dunlop, N., Connolly, V., Bilous, R., Kelly, W., Chantelau, E., Gede, A., Sharman, D., O Halloran, D., Best, C., Abbas, Z. G., Lutale, J., Gill, G. V., Jarvis, W. R., Archibald, L. K., Corcoran, S., Mansell, J., Pibworth, L., Terada, H., Shiba, T., Utugi, N., Utugi, T., Blum, M., Strobel, J., Hoffken, K., Razvi, F. M., Kritzinger, E. E., Taylor, K., Jones, S., Illahi, W., Grubetaer, M., Hartmann, P., Hoffstadt, K., Leiden, H. A., Moll, A. C., Polak, B. C. P., Pietragalla, G. B., Maurino, M., Montanaro, M., Karadeniz, S., Tommasini, P., Quadrini, C., Demiraj, V., Rispoli, E., Ota, A., Takama, H., Saito, N., Hemandez, C., Lepore, D., Antico, L., Giardina, B., Franconi, F., Michoud, E., Chamot, S., Riva, Ch, Hammes, H-P, Renner, O., Breier, G., Lin, J., Alt, A., Betzholtz, C., Bretzel, R. G. Rd, Manti, R., Gallo, M., Molinar Hin, A., Brignardello, E., Boccuzzi, G., Li, Shanfang, Xiang, Kunsan, Zhang, Rugeng, Shangguan, Xinhong, Wu, Jianrong, Donnan, P. T., Broomhall, J., Hunter, K., Morris, A. D., Darts Memo, Collaboration, Ioannidis, G., Peppa, M., Rontogianni, E., Kallifronas, M., Lekatsas, I., Chrysanthopoulou, G., Anthopoulos, L., Kesse, M., Thalassinos, N., Neves, C., Medina, J. L., Lopes, F., Guvener, N., Guvener, M., Kocagoz, T., Boke, E., Pasaoglu, I., Bascil Tutuncu, N., Oto, A., Karvonen, M. K., Koulu, M., Pesonen, U., Mercuri, M., Rauramaa, R., Pittsburgh Epidemiology of Diabetes Complications (EDC) Study, Rutter, M. K., Kestevan, P., Mccomb, J. M., Marshall, S. M., Sobieska, M., Wiktorowicz, K., Kanters, S. D. J. M., Banga, J. D., Algra, A., Frijns, C. J. M., Beutler, J. J., Fijnheer, R., Nicoloff, G., Baydanoff, S., Stanimirova, N., Petrova, Ch, Lario, S., Campistol, J. M., Cases, A., Claria, J., Inigo, P., Esmatjcs, E., Sarman, B., Toth, M., Kocsis, I., Somogyi, A., Bumbure, A., Jachimowicz, K., Samson, J., Tomasiak, M., Sobol, A., Stanczyk, L., Watala, C., Stradina, P., Wisniewska-Jarosinska, M., Marciniak, D., Wieclawska, B., Golanski, J., Zinnat, R., Mahmud, I., Buyukasik, Yahya, Demiroglu, H., Szczepanik, A., Skowronski, M., Murawska, A., Meeking, D. R., Allard, S., Munday, J., Chowienczyk, P., Shaw, K. M., Cummings, M. H., Simkova, R., Jirsa, M., Hadoke, P. W. F., Mcintyre, C. A., Jones, G. C., Williams, B. C., Elliott, A. I., Mcknight, J. A., Pernow, J., Bombonato, G. C., Finucci, G. F., Zotta, L., Senses, V., Ozyazgan, S., Ince, E., Tuncdemir, M., Sultuybek, G., Akkan, A. G., Unlucerci, Y., Bekpinar, S., Meyer, M. F., Lee, B. C., Shore, A. C., Humphreys, J. M., Tooke, J. E., Omo, G., Giovannitti, G., Caricato, F., Mariani, M., Pedrinelli, R., Kiviet-Boehm, C., Schwelling, V., Pfohl, M., Mcinerney, D., Itoh, H., Ohno, T., Katoh, N., Baumgartner-Parzer, S., Artwohl, M., Graier, W., Ludwig, C., Tachi, Y., Bannai, C., Shinohara, M., Shimpuku, H., Ohura, K., Bertacca, A., Sasvari, M., Szaleczki, E., Pusztai, P., Boes, U., Klaus, E., Dittrich, P., Wagner, Z., Wittmann, I., Poto, L., Wagner, L., Mazak, I., Nagy, J., Feletto, F., Taboga, C., Tonutti, L., Lizzio, S., Russo, A., Selmo, V., Ceriello, A., Lekakis, J., Papamichael, C. M., Stamatelopoulos, K., Stamatelopoulos, S., Yillar, D. O., Gay, M., Lillaz, E., Passaro, A., Vanini, A., Calzoni, F., D Elia, K., Carantoni, M., Zuliani, G., Fellin, R., Solini, A., Chwatko, G., Bald, E., Dramais, A-S, Wallemacq, P. E., Vandeleene, B., Ciaria, M. V., Ariano, M., Strom, R., Gibney, J., Weiss, U., Turner, B., O Gorman, P., Watts, G., Powrie, J., Crook, M., Shaw, K., and Cummings, M. more...
6. Anti-SARS-CoV-2 vaccines in recipient and/or donor before allotransplant.
- Author
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Jullien M, Coste-Burel M, Clemenceau B, Letailleur V, Guillaume T, Peterlin P, Garnier A, Bourgeois AL, Imbert BM, Ollier J, Grain A, Touzeau C, Moreau P, Béné MC, Vié H, and Chevallier P
- Abstract
The impact of pre-transplant anti-severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccine in 20 recipients of allogeneic hematopoietic stem cell transplantation (Allo-HSCT) and/or their donors is reported here, showing that the persistence of anti-SARS-CoV-2 antibodies can be detected in almost all patients, whatever the type of vaccine used, and up to 9 months post transplant. Also, an anti-SARS-CoV-2 spike glycoprotein CD3+ T-cell response could be detected in six (35%) of 17 evaluable patients. This study provides a rationale to consider anti-SARS-CoV-2 vaccination of both recipients and donors before Allo-HSCT., Competing Interests: The authors declare no conflict of interest., (© 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.) more...
- Published
- 2022
- Full Text
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7. Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response.
- Author
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Makanga DR, Jullien M, David G, Legrand N, Willem C, Dubreuil L, Walencik A, Touzeau C, Gastinne T, Tessoulin B, Le Gouill S, Mahé B, Gagne K, Chevallier P, Clemenceau B, and Retière C
- Subjects
- Antibody-Dependent Cell Cytotoxicity, Humans, Ligands, Killer Cells, Natural, Lymphoma, Receptors, KIR, Rituximab pharmacology
- Abstract
The antibody-dependent cellular cytotoxicity (ADCC) effector function of natural killer (NK) cells is one of the known mechanisms of action for rituximab-based anti-cancer immunotherapy. Inhibition of the ADCC function of NK cells through interactions between inhibitory killer cell immunoglobulin-like receptors (KIRs) and HLA class I ligands is associated with resistance of cancers to rituximab. In this study, we deeply investigated the impact of KIR, HLA class I, and CD16 genotypes on rituximab-dependent NK cell responses in both an in vitro cellular model from healthy blood donors and ex vivo rituximab-treated non-Hodgkin lymphoma (NHL) patients. We highlight that an HLA environment with limited KIR ligands is beneficial to promoting a higher frequency of KIR
+ NK cells including both educated and uneducated NK cells, two NK cell compartments that demonstrate higher rituximab-dependent degranulation than KIR- NK cells. In contrast, a substantial KIR ligand environment favors a higher frequency of poorly effective KIR- NK cells and numerous functional KIR/HLA inhibitions of educated KIR+ NK cells. These phenomena explain why NHL patients with limited KIR ligands respond better to rituximab. In this HLA environment, CD16 polymorphism appears to have a collateral effect. Furthermore, we show the synergic effect of KIR2DS1, which strongly potentiates NK cell ADCC from C2- blood donors against C2+ target cells. Taken together, these results pave the way for stronger prediction of rituximab responses for NHL patients. HLA class I typing and peripheral blood KIR+ NK cell frequency could be simple and useful markers for predicting rituximab response., (© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.) more...- Published
- 2021
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8. Genetic and Molecular Basis of Heterogeneous NK Cell Responses against Acute Leukemia.
- Author
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Makanga DR, Da Rin de Lorenzo F, David G, Willem C, Dubreuil L, Legrand N, Guillaume T, Peterlin P, Lebourgeois A, Béné MC, Garnier A, Chevallier P, Gendzekhadze K, Cesbron A, Gagne K, Clemenceau B, and Retière C more...
- Abstract
Natural killer (NK) cells are key cytotoxic effectors against malignant cells. Polygenic and polymorphic Killer cell Immunoglobulin-like Receptor (KIR) and HLA genes participate in the structural and functional formation of the NK cell repertoire. In this study, we extensively investigated the anti-leukemic potential of NK cell subsets, taking into account these genetic parameters and cytomegalovirus (CMV) status. Hierarchical clustering analysis of NK cell subsets based on NKG2A, KIR, CD57 and NKG2C markers from 68 blood donors identified donor clusters characterized by a specific phenotypic NK cell repertoire linked to a particular immunogenetic KIR and HLA profile and CMV status. On the functional side, acute lymphoblastic leukemia (ALL) was better recognized by NK cells than acute myeloid leukemia (AML). However, a broad inter-individual disparity of NK cell responses exists against the same leukemic target, highlighting bad and good NK responders. The most effective NK cell subsets against different ALLs expressed NKG2A and represented the most frequent subset in the NK cell repertoire. In contrast, minority CD57
+ or/and KIR+ NK cell subsets were more efficient against AML. Overall, our data may help to optimize the selection of hematopoietic stem cell donors on the basis of immunogenetic KIR/HLA for ALL patients and identify the best NK cell candidates in immunotherapy for AML. more...- Published
- 2020
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9. Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts.
- Author
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Jarry U, Joalland N, Chauvin C, Clemenceau B, Pecqueur C, and Scotet E
- Subjects
- Adoptive Transfer, Adult, Animals, Brain Neoplasms pathology, Cell Line, Tumor, Glioblastoma pathology, Heterografts, Humans, Mice, Xenograft Model Antitumor Assays, Brain Neoplasms immunology, Glioblastoma immunology
- Abstract
Glioblastoma multiforme (GBM), the most frequent and aggressive primary brain cancer in adults, is generally associated with a poor prognosis, and scarce efficient therapies have been proposed over the last decade. Among the promising candidates for designing novel therapeutic strategies, cellular immunotherapies have been targeted to eliminate highly invasive and chemo-radioresistant tumor cells, likely involved in a rapid and fatal relapse of this cancer. Thus, administration(s) of allogeneic GBM-reactive immune cell effectors, such as human Vϒ9Vδ2 T lymphocytes, in the vicinity of the tumor would represents a unique opportunity to deliver efficient and highly concentrated therapeutic agents directly into the site of brain malignancies. Here, we present a protocol for the preparation and the stereotaxic administration of allogeneic human lymphocytes in immunodeficient mice carrying orthotopic human primary brain tumors. This study provides a preclinical proof-of-concept for both the feasibility and the antitumor efficacy of these cellular immunotherapies that rely on stereotactic injections of allogeneic human lymphocytes within intrabrain tumor beds. more...
- Published
- 2018
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10. GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR.
- Author
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Straetemans T, Kierkels GJJ, Doorn R, Jansen K, Heijhuurs S, Dos Santos JM, van Muyden ADD, Vie H, Clemenceau B, Raymakers R, de Witte M, Sebestyén Z, and Kuball J
- Subjects
- Biomarkers, Cell Culture Techniques, Cell Line, Cytotoxicity, Immunologic, Enzyme-Linked Immunosorbent Assay, Genetic Vectors genetics, Humans, Immunophenotyping, Immunotherapy, Adoptive methods, Immunotherapy, Adoptive standards, Lymphocyte Activation immunology, Neoplasms genetics, Neoplasms immunology, Neoplasms therapy, Receptors, Chimeric Antigen genetics, Receptors, Chimeric Antigen metabolism, Transduction, Genetic, Transgenes, Batch Cell Culture Techniques methods, Batch Cell Culture Techniques standards, Gene Expression, Genetic Engineering, Receptors, Antigen, T-Cell, gamma-delta genetics, T-Lymphocytes immunology, T-Lymphocytes metabolism
- Abstract
γ9δ2T cells play a critical role in daily cancer immune surveillance by sensing cancer-mediated metabolic changes. However, a major limitation of the therapeutic application of γ9δ2T cells is their diversity and regulation through innate co-receptors. In order to overcome natural obstacles of γ9δ2T cells, we have developed the concept of T cells engineered to express a defined γδT cell receptor (TEGs). This next generation of chimeric antigen receptor engineered T (CAR-T) cells not only allows for targeting of hematological but also of solid tumors and, therefore, overcomes major limitations of many CAR-T and γδT cell strategies. Here, we report on the development of a robust manufacturing procedure of T cells engineered to express the high affinity Vγ9Vδ2T cell receptor (TCR) clone 5 (TEG001). We determined the best concentration of anti-CD3/CD28 activation and expansion beads, optimal virus titer, and cell density for retroviral transduction, and validated a Good Manufacturing Practice (GMP)-grade purification procedure by utilizing the CliniMACS system to deplete non- and poorly-engineered T cells. To the best of our knowledge, we have developed the very first GMP manufacturing procedure in which αβTCR depletion is used as a purification method, thereby delivering untouched clinical grade engineered immune cells. This enrichment method is applicable to any engineered T cell product with a reduced expression of endogenous αβTCRs. We report on release criteria and the stability of TEG001 drug substance and TEG001 drug product. The GMP-grade production procedure is now approved by Dutch authorities and allows TEG001 to be generated in cell numbers sufficient to treat patients within the approved clinical trial NTR6541. NTR6541 will investigate the safety and tolerability of TEG001 in patients with relapsed/refractory acute myeloid leukemia, high-risk myelodysplastic syndrome, and relapsed/refractory multiple myeloma. more...
- Published
- 2018
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11. Impact on early outcomes and immune reconstitution of high-dose post-transplant cyclophosphamide vs anti-thymocyte globulin after reduced intensity conditioning peripheral blood stem cell allogeneic transplantation.
- Author
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Retière C, Willem C, Guillaume T, Vié H, Gautreau-Rolland L, Scotet E, Saulquin X, Gagne K, Béné MC, Imbert BM, Clemenceau B, Peterlin P, Garnier A, and Chevallier P
- Abstract
We have compared prospectively the outcome and immune reconstitution of patients receiving either post-transplant cyclophosphamide (PTCY) ( n = 30) or anti-thymocyte globulin ATG ( n = 15) as Graft-versus-host disease (GVHD) prophylaxis after reduced-intensity conditioning (RIC) allogeneic peripheral blood stem cell (PBSC) transplantation (allo-SCT). The outcome and immune reconstitution of patients receiving either of these two regimens were compared prospectively. This study allowed also to investigate the impact of PTCY between haplo-identical vs matched donors and of clofarabine as part of the RIC regimen. The γ/δ T-cells, α/β T-cells (CD8
+ and CD4+ ), NK T-cells, NK cells, B-cells, Tregs and monocytes were analyzed by flow cytometry from a total of 583 samples. In the PTCY group significant delayed platelets recovery, higher CD3+ donor chimerism, higher HHV-6 and lower EBV reactivations were observed. Early survival advantage for CD4+ T-cells, Tregs and α/β T-cells was documented in the PTCY group while it was the case for α/β T-cells, NK cells and monocytes in the ATG group. Higher counts of NK and monocytes were observed at days +30 and/or day+60 in the ATG group. Both results were retained even in the case of mismatched donors. However, higher percentages of CD4+ T-cells, α/β T-cells and Tregs were observed with haplo-identical donors in the PTCY group. Finally, clofarabine was responsible for early survival advantage of NK T-cells in the PTCY group while it abrogated the early survival advantage of γ/δ T-cells in the ATG group. In conclusion, there are marked differences in the immunological effects of ATG vs PTCY as GVHD prophylaxis for RIC PBSC allo-SCT., Competing Interests: CONFLICTS OF INTEREST The authors declared no conflicts of interest. more...- Published
- 2018
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12. A monoclonal antibody to O-acetyl-GD2 ganglioside and not to GD2 shows potent anti-tumor activity without peripheral nervous system cross-reactivity.
- Author
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Alvarez-Rueda N, Desselle A, Cochonneau D, Chaumette T, Clemenceau B, Leprieur S, Bougras G, Supiot S, Mussini JM, Barbet J, Saba J, Paris F, Aubry J, and Birklé S
- Subjects
- Apoptosis drug effects, Cell Line, Tumor, Cell Survival drug effects, Humans, In Vitro Techniques, Neuroblastoma metabolism, Peripheral Nervous System pathology, Antibodies, Monoclonal immunology, Antibodies, Monoclonal pharmacology, Gangliosides immunology, Peripheral Nervous System drug effects
- Abstract
Background: Monoclonal antibodies (mAb) against GD2 ganglioside have been shown to be effective for the treatment of neuroblastoma. Beneficial actions are, however, associated with generalized pain due to the binding of anti- GD2 mAbs to peripheral nerve fibers followed by complement activation. Neuroblastoma cells that express GD2 also express its O-acetyl derivative, O-acetyl- GD2 ganglioside (OAcGD2). Hence, we investigated the distribution of OAcGD2 in human tissues using mAb 8B6 to study the cross-reactivity of mAb 8B6 with human tissues., Methodology/principal Findings: The distribution of OAcGD2 was performed in normal and malignant tissues using an immunoperoxydase technique. Anti-tumor properties of mAb 8B6 were studied in vitro and in vivo in a transplanted tumor model in mice. We found that OAcGD2 is not expressed by peripheral nerve fibers. Furthermore, we demonstrated that mAb 8B6 was very effective in the in vitro and in vivo suppression of the growth of tumor cells. Importantly, mAb 8B6 anti-tumor efficacy was comparable to that of mAb 14G2a specific to GD2., Conclusion/significance: Development of therapeutic antibodies specific to OAcGD2 may offer treatment options with reduced adverse side effects, thereby allowing dose escalation of antibodies. more...
- Published
- 2011
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13. Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis.
- Author
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Hudrisier D, Clemenceau B, Balor S, Daubeuf S, Magdeleine E, Daëron M, Bruhns P, and Vié H
- Subjects
- Animals, Antigen Presentation immunology, Antigen-Antibody Complex immunology, B-Lymphocytes metabolism, CD4-Positive T-Lymphocytes metabolism, CD8-Positive T-Lymphocytes metabolism, Calcium immunology, Calcium metabolism, Cell Communication immunology, Cell Line, Cell Line, Tumor, Coculture Techniques, Dendritic Cells metabolism, Histocompatibility Antigens Class I metabolism, Humans, Ligands, Mice, Mice, Transgenic, Muramidase immunology, Ovalbumin immunology, Peptide Fragments immunology, Receptors, IgG metabolism, Signal Transduction immunology, Transfection, B-Lymphocytes immunology, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, Dendritic Cells immunology, Histocompatibility Antigens Class I immunology, Receptors, IgG immunology
- Abstract
Intercellular transfer of cell surface proteins by trogocytosis is common and could affect T cell responses. Yet, the role of trogocytosis in T cell function is still elusive, and it is unknown whether a molecule, once captured by T cells, harbors the same biological properties as in donor APC. In this study, we showed that FcgammaR as well as the associated FcRgamma subunit could be detected at high levels on murine and human T cells after their intercellular transfer from FcgammaR-expressing APC. Capture of FcgammaR occurred during coculture of T cells with FcgammaR-expressing APC upon Ab- or Ag-mediated T cell stimulation. Once captured by T cells, FcgammaR were expressed in a conformation compatible with physiological function and conferred upon T cells the ability to bind immune complexes and to provision B cells with this source of Ag. However, we were unable to detect downstream signal or signaling-dependent function following the stimulation of FcgammaR captured by T cells, and biochemical studies suggested the improper integration of FcgammaR in the recipient T cell membrane. Thus, our study demonstrates that T cells capture FcgammaR that can efficiently exert ligand-binding activity, which, per se, could have functional consequences in T cell-B cell cooperation. more...
- Published
- 2009
- Full Text
- View/download PDF
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