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2. Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis

Author

Gaertner, Florian, Ishikawa-Ankerhold, Hellen, Stutte, Susanne, Fu, Wenwen, Weitz, Jutta, Dueck, Anne, Nelakuditi, Bhavishya, Fumagalli, Valeria, van den Heuvel, Dominic, Belz, Larissa, Sobirova, Gulnoza, Zhang, Zhe, Titova, Anna, Navarro, Alejandro Martinez, Pekayvaz, Kami, Lorenz, Michael, von Baumgarten, Louisa, Kranich, Jan, Straub, Tobias, Popper, Bastian, Zheden, Vanessa, Kaufmann, Walter Anton, Guo, Chenglong, Piontek, Guido, von Stillfried, Saskia, Boor, Peter, Colonna, Marco, Clauß, Sebastian, Schulz, Christian, Brocker, Thomas, Walzog, Barbara, Scheiermann, Christoph, Aird, William C., Nerlov, Claus, Stark, Konstantin, Petzold, Tobias, Engelhardt, Stefan, Sixt, Michael, Hauschild, Robert, Rudelius, Martina, Oostendorp, Robert A. J., Iannacone, Matteo, Heinig, Matthias, and Massberg, Steffen

Published
2024
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3. Innate immune memory after brain injury drives inflammatory cardiac dysfunction

Author

Simats, Alba, Zhang, Sijia, Messerer, Denise, Chong, Faye, Beşkardeş, Sude, Chivukula, Aparna Sharma, Cao, Jiayu, Besson-Girard, Simon, Montellano, Felipe A., Morbach, Caroline, Carofiglio, Olga, Ricci, Alessio, Roth, Stefan, Llovera, Gemma, Singh, Rashween, Chen, Yiming, Filser, Severin, Plesnila, Nikolaus, Braun, Christian, Spitzer, Hannah, Gokce, Ozgun, Dichgans, Martin, Heuschmann, Peter U., Hatakeyama, Kinta, Beltrán, Eduardo, Clauss, Sebastian, Bonev, Boyan, Schulz, Christian, and Liesz, Arthur

Published
2024
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4. Encryption Proxies in a Confidential Computing Environment

Author

Al Bouhairi, Mohamad Jamil, Mullick, Mostakim, Wolf, Marvin, Gudymenko, Ivan, Clauss, Sebastian, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Wang, Guojun, editor, Choo, Kim-Kwang Raymond, editor, Wu, Jie, editor, and Damiani, Ernesto, editor

Published
2023
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7. Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism—the Find-AF 2 study—rationale and design

Author

Wachter, Rolf, Gröschel, Klaus, Wasser, Katrin, Uhe, Tobias, Schäbitz, Wolf-Rüdiger, Köhrmann, Martin, Dichgans, Martin, Gröschel, Sonja, Uphaus, Timo, Hahn, Marianne, Zuhorn, Frederic, Wulff, Leonard, Plümer, Jorge, Kok, Lena, Janz, Marcel, Kitsiou, Alkisti, Gehmeyr, Julian, Dabbagh, Alhuda, Huber, Charlotte, Pelz, Johann, Wartenberg, Katja, Michalski, Dominik, Seidel, Mirko, Flissakowski, Oscar, Goschenhofer, Anna, Hussain, Rabia-Basari, Kim, Ina, Kinze, Stephan, Kroneberger, Christian, Lingnau, Michale, Lischewski, Dennis, Muhn, Florian, Rogge, Witold, Schieffer, Miriam, Setayesh-Roonizi, Anuscheh, Sparenberg, Paul, Schertel, Jill Marie, Ringleb, Peter, Purrucker, Jan, Berberich, Anne, Heyse, Miriam, Ungerer, Matthias, Bauer, Gregor, Reichardt, Christine, Etgen, Thorleif, Ebel, Bernhard, Milanković-Eberl, Dragana, Schwarte, Olav, Höcherl, Constanze, Asch, Eric-Manuel, Bojtschuk, Luisa, Frey, Maximilian, Dlouhy, Tomas, Ertl, Michael, Zickler, Philipp Patrick, Beier, Barbara, Braadt, Lino-Dominic, Gabrielyan, Inessa, Kermer, Pawel, Kaste, Matthias, Anter, Ahmed, Stirbulescu, Corina, Meleshchenco, Nataliia, Burgholte, Friederike, Lüers, Claus, Steiner, Thorsten, Cierpinski, Mari-Carmen, Lichti, Bethke, Florian, Bonowski, Lars, Eid, Hassan Abou, Vajda-Medina, Esteban, Probst, Mareike, Essa, Hisham, Frank, Benedikt, Stolte, Benjamin, Milles, Lennart, Soda, Hassan, Hiermann, Erich, Rascher, Renate Weinhardt Alexandra, Stan, Marius, Kääb, Stefan, Kellert, Lars, Dimitriadis, Konstantinos, Kopczak, Anna, Küster, Bettina, Sinner, Moritz, Steiger, Ignaz, Kaffe, Maria, Clauß, Sebastian, Janowitz, Daniel, Thaler, Raffael, Schellinger, Peter, Glahn, Jörg, Schubert, Jan, Jenniges, Simone, Markmann-Boenke, Silke, Putzer, Anne-Sophie, Straeten, Michael Schwarze Vera, Wiemer, Marcus, Kallmünzer, Bernd, Macha, Kosmas, Haupenthal, David, Balk, Stefanie, Kossel, Clara-Sophie, Häusler, Georg, Lehrieder, Dominik, Cidlinsky, Peter, Hametner, Christian, Vogl, Christine, Fischer, Thomas, Huttelmaier, Moritz, Nordbeck, Octavian Maniuc Peter, von Hardenberg, Albrecht, Jünemann, Martin, Braun, Tobias, Viard, Maxime, Gerner, Stefan, Omar, AlHaj, Genau, Sonja, Olbricht, Linus, Wassenberg, Matthias, Langguth, Niklas, Fräbel, Christian, Baumgart, Romy, Kalra, Love-Preet, Diel, Norma, Hoffmann, Frank, Kraft, Andrea, Schönmuth, Bettine, Giebler, Anja, Weber, Lorenz, Grond, Martin, Birringer, Jan, Lichte-Schneider, Sandra, Hütwohl, Daniela, Krause, Lars Udo, Petersen, Martina, Althaus, Katharina, Kirchmeier, Konstantin, Novikova, Liubov, Müller, Susanne, Schellong, Sebastian, Brudzinski, Mirko, Gerk, Ulrich, Palisch, Holger, Heinzel, Frank R., Fett, Jana, Suntha, Avinash, Burian, Katja, Schmitz, Bettina, Gutwinski, Anna, Angermüller, Veronika, Alhammoud, Tameem, Cakiroglu, Hüsniye, Bach, Ullrich, Nabavi, Darius, Offermann, Jens, Crome, Olaf, Dimitrijeski, Boris, Meincke, Carsten, Hamann, Gerhard, Alber, Burkhard, Müller, Robert, Pallesen, Lars-Peder, Pütz, Volker, Hartmann, Christian, Berrouschot, Jörg, Stoll, Anett, Keilitz, Janina, Klunk, Dietrich, Voigt, Roman, Kastrup, Andreas, Schröter, Andreas, Schmucker, Johannes, Pfeilschifter, Waltraud, Krämer, Christoffer, Wiemers, Milena, Simon, Micha, Finke, Alexander, Weiß, Christian, Hobohm, Carsten, Naupold, Katrin, Bley-Renning, Karen, Winter, Sabrina, Poli, Sven, Mengel, Annerose, Poli, Khouloud, Expósito, Alexandra Gómez, Mbroh, Joshua, Tieck, Maria, Rosenkranz, Michael, Boskamp, Stefan, Ritter, Nicolas, Seibel, Lena, Schöps, Christian, Ketzler, Rebecca, Nägele, Herbert, Sydow, Karsten, Kurka, Natalia, Schäfer, Jan Hendrik, Charisse, Daniel, Gruber, Katharina, Kohlhase, Konstantin, Lieschke, Franziska, Operhalski, Felix, Seiler, Alexander, Petzold, Gabor, Bode, Felix Jürgen, Stösser, Sebastian, Meißner, Julius, Ebrahimi, Taraneh, Nordsiek, Julia, Beckonert, Niklas, Weissenborn, Karin, Große, Gerrit Maximilian, Worthmann, Hans, Hennemann, Ann-Katrin, Jochmann, Svenja, Gründahl, Julius, Al-Ayoubi, Jana, Ernst, Johanna, Bähr, Oliver, Gruber, Herbert, Benesch, Sonka, Pollinger, Thomas, Alachkar, Nawar, Busch, Sonia, Butz, Steffi, Forkmann, Mathias, Mahnkopf, Christian, Mischke, Thomas, Schnupp, Steffen, Thomalla, Götz, Deb-Chatterji, Milani, Cheng, Bastian, Gelderblom, Mathias, Hoppe, Julia, Jensen, Märit, Schell, Maximilian, Schlemm, Eckhard, Marquardt, Lars, Kazarians, Haiko, Rheingans, Pia Franziska, Hötzer, Kai, Rose, Dietmar, Neumann-Haefelin, Tobias, Berthel, Jörg, Alijaj, Lirim, Krug, Joachim, Niethammer, Margit, Szöllösi, Géza-Attila, Obermann, Marc, Adochitei, Nicoletta, Strik, Herwig, Lenz, Arne, Steigerwald, Frank, Müller, Jörg, Honermann, Martin, Burgstaller, Marian Christoph, Kollmar, Rainer, Rashid, Maryam, Ganai, Ahmad Ajaz, Ossendorf, Saric, Majda, Tischer, Karl-Heinz, Toluli, Adela, Wollenweber, Frank Arne, Rahban, Laya, Silva, Thais Portugal, Lee, Miri, Grosch, Matthias Julius, Minnerup, Jens, Liman, Jan, Nückel, Martin, Böhm, Magdalena, Weber-Krüger, Mark, Brachmann, Johannes, Laufs, Ulrich, Gelbrich, Götz, Petroff, David, Prettin, Christiane, Schellinger, Peter D., Hamann, Gerhard F., Mende, Meinhard, and Wagner, Marcus

Published
2023
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8. Abstract 12226: Aging Impairs the Neuro-Vascular Interface in the Heart

Author

Wagner, Julian U, Tombor, Lukas, Malacarne, Pedro F, Manickam, Nivethitha, Abplanalp, Wesley T, John, David, Buchmann, Giulia Karolin K, Angendohr, Stephan, Amin, Ehsan, Scherschel, Katharina, Nikolaj, Klöcker, Kelm, Malte, Schüttler, Dominik, Clauss, Sebastian, Guenther, Stefan, Braun, Thomas, Boettger, Thomas, Baer, Christian, Pham, Minh-Duc, Krishnan, Jaya, Hille, Susanne S, Mueller, Oliver, Bozoglu, Tarik, Kupatt, Christian, Nardini, Eleonora, Osmanagic-Myers, Selma, Meyer, Christian, Zeiher, Andreas M, Brandes, Ralf P, Luxan, Guillermo, and Dimmeler, Stefanie

Published
2023
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9. Ibrutinib-Mediated Atrial Fibrillation Attributable to Inhibition of C-Terminal Src Kinase.

Author

Xiao, Ling, Salem, Joe-Elie, Clauss, Sebastian, Hanley, Alan, Bapat, Aneesh, Hulsmans, Maarten, Iwamoto, Yoshiko, Wojtkiewicz, Gregory, Cetinbas, Murat, Schloss, Maximilian, Tedeschi, Justin, Lebrun-Vignes, Bénédicte, Lundby, Alicia, Sadreyev, Ruslan, Moslehi, Javid, Nahrendorf, Matthias, Ellinor, Patrick, and Milan, David

Subjects
BTK protein, human, CSK tyrosine-protein kinase, atrial fibrillation, electrophysiology, ibrutinib, protein kinase inhibitors, Action Potentials, Adenine, Agammaglobulinaemia Tyrosine Kinase, Animals, Antineoplastic Agents, Atrial Fibrillation, Atrial Function, Left, CSK Tyrosine-Protein Kinase, Databases, Genetic, Heart Atria, Heart Rate, Humans, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Knockout, Piperidines, Protein Kinase Inhibitors, Risk Assessment, Risk Factors
Abstract

BACKGROUND: Ibrutinib is a Bruton tyrosine kinase inhibitor with remarkable efficacy against B-cell cancers. Ibrutinib also increases the risk of atrial fibrillation (AF), which remains poorly understood. METHODS: We performed electrophysiology studies on mice treated with ibrutinib to assess inducibility of AF. Chemoproteomic analysis of cardiac lysates identified candidate ibrutinib targets, which were further evaluated in genetic mouse models and additional pharmacological experiments. The pharmacovigilance database, VigiBase, was queried to determine whether drug inhibition of an identified candidate kinase was associated with increased reporting of AF. RESULTS: We demonstrate that treatment of mice with ibrutinib for 4 weeks results in inducible AF, left atrial enlargement, myocardial fibrosis, and inflammation. This effect was reproduced in mice lacking Bruton tyrosine kinase, but not in mice treated with 4 weeks of acalabrutinib, a more specific Bruton tyrosine kinase inhibitor, demonstrating that AF is an off-target side effect. Chemoproteomic profiling identified a short list of candidate kinases that was narrowed by additional experimentation leaving CSK (C-terminal Src kinase) as the strongest candidate for ibrutinib-induced AF. Cardiac-specific Csk knockout in mice led to increased AF, left atrial enlargement, fibrosis, and inflammation, phenocopying ibrutinib treatment. Disproportionality analyses in VigiBase confirmed increased reporting of AF associated with kinase inhibitors blocking Csk versus non-Csk inhibitors, with a reporting odds ratio of 8.0 (95% CI, 7.3-8.7; P

Published
2020

14. Macrophages Facilitate Electrical Conduction in the Heart

Author

Hulsmans, Maarten, Clauss, Sebastian, Xiao, Ling, Aguirre, Aaron D, King, Kevin R, Hanley, Alan, Hucker, William J, Wülfers, Eike M, Seemann, Gunnar, Courties, Gabriel, Iwamoto, Yoshiko, Sun, Yuan, Savol, Andrej J, Sager, Hendrik B, Lavine, Kory J, Fishbein, Gregory A, Capen, Diane E, Da Silva, Nicolas, Miquerol, Lucile, Wakimoto, Hiroko, Seidman, Christine E, Seidman, Jonathan G, Sadreyev, Ruslan I, Naxerova, Kamila, Mitchell, Richard N, Brown, Dennis, Libby, Peter, Weissleder, Ralph, Swirski, Filip K, Kohl, Peter, Vinegoni, Claudio, Milan, David J, Ellinor, Patrick T, and Nahrendorf, Matthias

Subjects
Heart Disease, Cardiovascular, Aetiology, 2.1 Biological and endogenous factors, Animals, Connexin 43, Female, Heart Atria, Heart Conduction System, Humans, Macrophages, Male, Mice, Mice, Inbred C57BL, Middle Aged, Myocytes, Cardiac, atrioventricular node, computational modeling, connexin 43, electrical conduction, gap junctions, heart, macrophages, optogenetics, single-cell RNA-sequencing, tissue clearing, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with elongated macrophages expressing connexin 43. When coupled to spontaneously beating cardiomyocytes via connexin-43-containing gap junctions, cardiac macrophages have a negative resting membrane potential and depolarize in synchrony with cardiomyocytes. Conversely, macrophages render the resting membrane potential of cardiomyocytes more positive and, according to computational modeling, accelerate their repolarization. Photostimulation of channelrhodopsin-2-expressing macrophages improves atrioventricular conduction, whereas conditional deletion of connexin 43 in macrophages and congenital lack of macrophages delay atrioventricular conduction. In the Cd11bDTR mouse, macrophage ablation induces progressive atrioventricular block. These observations implicate macrophages in normal and aberrant cardiac conduction.

Published
2017

16. Atrial fibrosis heterogeneity is a risk for atrial fibrillation in pigs with ischaemic heart failure.

Author

Zhang, Zhihao, Vlcek, Julia, Pauly, Valerie, Hesse, Nora, Bauer, Julia, Chataut, Kavi Raj, Maderspacher, Florian, Volz, Lina Sophie, Buchberger, Katharina, Xia, Ruibing, Hildebrand, Bianca, Kääb, Stefan, Schüttler, Dominik, Tomsits, Philipp, and Clauss, Sebastian

Subjects
ATRIAL fibrillation, HEART failure, FIBROSIS, SWINE, LEFT heart atrium, BALLOON occlusion
Abstract

Background: Atrial fibrillation (AF) is the most common arrhythmia and is associated with considerable morbidity and mortality. Ischaemic heart failure (IHF) remains one of the most common causes of AF in clinical practice. However, ischaemia‐mediated mechanisms leading to AF are still incompletely understood, and thus, current treatment approaches are limited. To improve our understanding of the pathophysiology, we studied a porcine IHF model. Methods: In pigs, IHF was induced by balloon occlusion of the left anterior descending artery for 90 min. After 30 days of reperfusion, invasive haemodynamic measurements and electrophysiological studies were performed. Masson trichrome and immunofluorescence staining were conducted to assess interstitial fibrosis and myofibroblast activation in different heart regions. Results: After 30 days of reperfusion, heart failure with significantly reduced ejection fraction (left anterior obique 30°, 34.78 ± 3.29% [IHF] vs. 62.03 ± 2.36% [control], p <.001; anterior–posterior 0°, 29.16 ± 3.61% vs. 59.54 ± 1.09%, p <.01) was observed. These pigs showed a significantly higher susceptibility to AF (33.90% [IHF] vs. 12.98% [control], p <.05). Histological assessment revealed aggravated fibrosis in atrial appendages but not in atrial free walls in IHF pigs (11.13 ± 1.44% vs. 5.99 ±.86%, p <.01 [LAA], 8.28 ±.56% vs. 6.01 ±.35%, p <.01 [RAA]), which was paralleled by enhanced myofibroblast activation (12.09 ±.65% vs. 9.00 ±.94%, p <.05 [LAA], 14.37 ±.60% vs. 10.30 ± 1.41%, p <.05 [RAA]). Correlation analysis indicated that not fibrosis per se but its cross‐regional heterogeneous distribution across the left atrium was associated with AF susceptibility (r =.6344, p <.01). Conclusion: Our results suggest that left atrial cross‐regional fibrosis difference rather than overall fibrosis level is associated with IHF‐related AF susceptibility, presumably by establishing local conduction disturbances and heterogeneity. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Atrial fibrosis heterogeneity is a risk for atrial fibrillation in pigs with ischaemic heart failure

Author

Zhang, Zhihao, primary, Vlcek, Julia, additional, Pauly, Valerie, additional, Hesse, Nora, additional, Bauer, Julia, additional, Chataut, Kavi Raj, additional, Maderspacher, Florian, additional, Volz, Lina Sophie, additional, Buchberger, Katharina, additional, Xia, Ruibing, additional, Hildebrand, Bianca, additional, Kääb, Stefan, additional, Schüttler, Dominik, additional, Tomsits, Philipp, additional, and Clauss, Sebastian, additional

Published
2023
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21. Loss of the Atrial Fibrillation-Related Gene, Zfhx3 , Results in Atrial Dilation and Arrhythmias

Author

Jameson, Heather S., primary, Hanley, Alan, additional, Hill, Matthew C., additional, Xiao, Ling, additional, Ye, Jiangchuan, additional, Bapat, Aneesh, additional, Ronzier, Elsa, additional, Hall, Amelia Weber, additional, Hucker, William J., additional, Clauss, Sebastian, additional, Barazza, Miranda, additional, Silber, Elizabeth, additional, Mina, Julie A., additional, Tucker, Nathan R., additional, Mills, Robert W., additional, Dong, Jin-Tang, additional, Milan, David J., additional, and Ellinor, Patrick T., additional

Published
2023
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24. Effects of Sex on the Susceptibility for Atrial Fibrillation in Pigs with Ischemic Heart Failure

Author

Pauly, Valerie, primary, Vlcek, Julia, additional, Zhang, Zhihao, additional, Hesse, Nora, additional, Xia, Ruibing, additional, Bauer, Julia, additional, Loy, Simone, additional, Schneider, Sarah, additional, Renner, Simone, additional, Wolf, Eckhard, additional, Kääb, Stefan, additional, Schüttler, Dominik, additional, Tomsits, Philipp, additional, and Clauss, Sebastian, additional

Published
2023
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25. EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation

Author

Shoykhet, Maria, primary, Dervishi, Orsela, additional, Menauer, Philipp, additional, Hiermaier, Matthias, additional, Moztarzadeh, Sina, additional, Osterloh, Colin, additional, Ludwig, Ralf J., additional, Williams, Tatjana, additional, Gerull, Brenda, additional, Kaab, Stefan, additional, Clauss, Sebastian, additional, Schüttler, Dominik, additional, Waschke, Jens, additional, and Yeruva, Sunil, additional

Published
2023
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28. Atrial Fibrillation Risk Assessment after Embolic Stroke of Undetermined Source

Author

von Falkenhausen, Aenne S., primary, Feil, Katharina, additional, Sinner, Moritz F., additional, Schönecker, Sonja, additional, Müller, Johanna, additional, Wischmann, Johannes, additional, Eiffener, Elodie, additional, Clauss, Sebastian, additional, Poli, Sven, additional, Poli, Khouloud, additional, Zuern, Christine S., additional, Ziemann, Ulf, additional, Berrouschot, Jörg, additional, Kitsiou, Alkisti, additional, Schäbitz, Wolf‐Rüdiger, additional, Dieterich, Marianne, additional, Massberg, Steffen, additional, Kääb, Stefan, additional, and Kellert, Lars, additional

Published
2022
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31. Further Privacy Mechanisms

Author

El Kalam, Anas Abou, Melchor, Carlos Aguilar, Berthold, Stefan, Camenisch, Jan, Clauß, Sebastian, Deswarte, Yves, Kohlweiss, Markulf, Panchenko, Andriy, Pimenidis, Lexi, Roy, Matthieu, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Camenisch, Jan, editor, Leenes, Ronald, editor, and Sommer, Dieter, editor

Published
2011
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32. Privacy, Liveliness and Fairness for Reputation

Author

Schiffner, Stefan, Clauß, Sebastian, Steinbrecher, Sandra, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Černá, Ivana, editor, Gyimóthy, Tibor, editor, Hromkovič, Juraj, editor, Jefferey, Keith, editor, Králović, Rastislav, editor, Vukolić, Marko, editor, and Wolf, Stefan, editor

Published
2011
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33. Ageing impairs the neuro-vascular interface in the heart

Author

Wagner, Julian U. G., primary, Tombor, Lukas, additional, Malacarne, Pedro Felipe, additional, Kettenhausen, Lisa-Maria, additional, Panthel, Josefine, additional, Cipca, Maria, additional, Stilz, Kathrin A., additional, Fischer, Ariane, additional, Muhly-Reinholz, Marion, additional, Abplanalp, Wesley T., additional, John, David, additional, Buchmann, Giulia K., additional, Angendohr, Stephan, additional, Amin, Ehsan, additional, Scherschel, Katharina, additional, Klöcker, Nikolaj, additional, Kelm, Malte, additional, Schüttler, Dominik, additional, Clauss, Sebastian, additional, Guenther, Stefan, additional, Boettger, Thomas, additional, Braun, Thomas, additional, Bär, Christian, additional, Nardini, Eleonora, additional, Osmanagic-Myers, Selma, additional, Meyer, Christian, additional, Zeiher, Andreas M., additional, Brandes, Ralf P., additional, Luxán, Guillermo, additional, and Dimmeler, Stefanie, additional

Published
2022
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34. Privacy and Liveliness for Reputation Systems

Author

Schiffner, Stefan, Clauß, Sebastian, Steinbrecher, Sandra, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Martinelli, Fabio, editor, and Preneel, Bart, editor

Published
2010
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35. Identitätsmanagement in Netzwelten

Author

Steinbrecher, Sandra, Pfitzmann, Andreas, Clauß, Sebastian, Klumpp, Dieter, editor, Kubicek, Herbert, editor, Roßnagel, Alexander, editor, and Schulz, Wolfgang, editor

Published
2010
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36. Using Linkability Information to Attack Mix-Based Anonymity Services

Author

Schiffner, Stefan, Clauß, Sebastian, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goldberg, Ian, editor, and Atallah, Mikhail J., editor

Published
2009
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40. A Framework for Quantification of Linkability Within a Privacy-Enhancing Identity Management System

Author

Clauß, Sebastian, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Dough, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, and Müller, Günter, editor

Published
2006
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44. PO-630-07 INVESTIGATION OF DIABETES-INDUCED ATRIAL REMODELING IN A PRECLINICAL LARGE ANIMAL MODEL

Author

Clauss, Sebastian, primary, Tomsits, Philipp, additional, Vlcek, Julia, additional, Pauly, Valerie, additional, Hesse, Nora, additional, Xia, Ruibing, additional, Loy, Simone, additional, Volz, Lina-Sophie, additional, Villgrater, Hannes Elias, additional, KOTTU, LAKSHME, additional, Renner, Simone, additional, Kaab, Stefan, additional, Wolf, Eckhard, additional, and Schüttler, Dominik, additional

Published
2022
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50. Atrial Fibrillation Risk Assessment after Embolic Stroke of Undetermined Source.

Author

von Falkenhausen, Aenne S., Feil, Katharina, Sinner, Moritz F., Schönecker, Sonja, Müller, Johanna, Wischmann, Johannes, Eiffener, Elodie, Clauss, Sebastian, Poli, Sven, Poli, Khouloud, Zuern, Christine S., Ziemann, Ulf, Berrouschot, Jörg, Kitsiou, Alkisti, Schäbitz, Wolf‐Rüdiger, Dieterich, Marianne, Massberg, Steffen, Kääb, Stefan, and Kellert, Lars

Subjects
ATRIAL fibrillation, RISK assessment, UNIVERSITY hospitals, CONFIDENCE intervals
Abstract

Objective: Approximately 20% of strokes are embolic strokes of undetermined source (ESUS). Undetected atrial fibrillation (AF) remains an important cause. Yet, oral anticoagulation in unselected ESUS patients failed in secondary stroke prevention. Guidance on effective AF detection is lacking. Here, we introduce a novel, non‐invasive AF risk assessment after ESUS. Methods: Catch‐Up ESUS is an investigator‐initiated, observational cohort study conducted between 2018 and 2019 at the Munich University Hospital. Besides clinical characteristics, patients received ≥72 h digital electrocardiogram recordings to generate the rhythm irregularity burden. Uni‐ and multivariable regression models predicted the primary endpoint of incident AF, ascertained by standardized follow‐up including implantable cardiac monitors. Predictors included the novel rhythm irregularity burden constructed from digital electrocardiogram recordings. We independently validated our model in ESUS patients from the University Hospital Tübingen, Germany. Results: A total of 297 ESUS patients were followed for 15.6 ± 7.6 months. Incident AF (46 patients, 15.4%) occurred after a median of 105 days (25th to 75th percentile 31–33 days). Secondary outcomes were recurrent stroke in 7.7% and death in 6.1%. Multivariable‐adjusted analyses identified the rhythm irregularity burden as the strongest AF‐predictor (hazard ratio 3.12, 95% confidence interval 1.62–5.80, p < 0001) while accounting for the known risk factors age, CHA2DS2‐VASc‐Score, and NT‐proBNP. Independent validation confirmed the rhythm irregularity burden as the most significant AF‐predictor (hazard ratio 2.20, 95% confidence interval 1.45–3.33, p < 0001). Interpretation: The novel, non‐invasive, electrocardiogram‐based rhythm irregularity burden may help adjudicating AF risk after ESUS, and subsequently guide AF‐detection after ESUS. Clinical trials need to clarify if high‐AF risk patients benefit from tailored secondary stroke prevention. ANN NEUROL 2023;93:479–488 [ABSTRACT FROM AUTHOR]

Published
2023
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