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The planetary boundaries (PBs) are a widely used framework defining a “safe operating space” for environmental sustainability at the global level. However, they do not straightforwardly translate into indicators applicable in a building project. This paper proposes a procedure to set and assess absolute sustainability targets related to the PBs in a building project, exemplified in the case of Denmark. The first step is to ensure that the targets and the assessment method use comparable indicators. Common building life cycle assessment (LCA) tools use impact categories that do not directly match the PBs. Two options are considered to address this issue. Dedicated characterization factors can be used to convey LCA results in indicators consistent with the PBs. Alternatively, PB targets can be converted into LCA impact categories. Then, several distributive justice principles are reviewed to allocate a share of planetary sustainability targets to an individual country, to the housing sector within that country, and to an individual project. We argue that principles that conserve existing unsustainable paradigms are not appropriate to set planetary sustainability targets, and propose a novel approach for sectorial allocation based on sufficientarianism and “decent living” scenarios. Finally, challenges related to the assessment of these targets are highlighted. In particular, the paper draws attention to differences in system boundaries between the LCA and the targets.

APOE genotype is the strongest genetic risk factor for Alzheimer’s Disease (AD). The low degree of homology between mouse and human APOE is a concerning issue in preclinical models currently used to study the role of this gene in AD pathophysiology. A key objective of ADAPTED (Alzheimer’s Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project was to generate in vitro models that better recapitulate human APOE biology. We describe a new set of induced pluripotent stem cells (iPSC) lines carrying common APOE variants (Ɛ2, Ɛ3, and Ɛ3/Ɛ4) and a knock-out isogenic to the parental APOE Ɛ4/Ɛ4 line (UKBi011-A).

Pristinely preserved mineral pseudomorphs called glendonites, up to 1.6 m long, from the Palaeogene strata of Denmark allow detailed crystallographic characterisation and add to the understanding of the transformation of the precursor mineral, ikaite (CaCO3·6H2O), to calcite, which constitutes the glendonite. We describe Danish pseudomorphs after ikaite from two localities and formations: the Early Eocene Fur Formation and the Late Oligocene Brejning Formation. This detailed study highlights that key aspects such as morphology and mode of occurrence of these ancient glendonites are identical to those of their parent mineral ikaite, when it grows in marine sediments. Systematic distortion of the angles in glendonite and marine sedimentary ikaite relative to the ideal ikaite symmetry may arise due to the incorporation of organic matter into the crystal structure, and we demonstrate the similarity between modern and ancient ikaite formation zones in the marine sedimentary realm with respect to organic matter.