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177 results on '"Claus, Detlef"'

1. Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial

Author

Beyersdorf, Friedhelm, Macharzina, Roland-Richard, Lechner, Gabriele, Menz, Carolin, Schonhardt, Sabine, Weinbeck, Michael, Greb, Olga, Otto, Dagmar, Winker, Thomas, Berger, Hermann, Poppert, Holger, Kühnl, Andreas, Pütz, Volker, Haase, Kathrin, Bodechtel, Ulf, Weiss, Norbert, Bergert, Hendrik, Meyne, Johannes, Groß, Justus, Kruse, Matthias, Gerdes, Berthold, Reinbold, Wolf-Dieter, Wuttig, Helge, Maier-Hasselmann, Andreas, Segerer, Manuela, Fuchs, Hans-Hermann, Gass, Sabine, Groden, Christoph, Niedergethmann, Marco, Griebe, Martin, Rosenkranz, Michael, Beck, Jürgen, Thomalla, Götz, Zeumer, Hermann H., Jauß, Marek, Kneist, Werner, Kneist, Martina, Staudacher, Thomas, Bernhard, Alfons, Jost, Petra, Prey, Nico, Knippschild, Jürgen, Kastrup, Oliver, Köhrmann, Martin, Frank, Benedikt, Bongers, Volkmar, Hoffmann, Johannes, Kniemeyer, Horst-Wilhelm, Knauth, Michael, Wasser, Kathrin, Stojanovic, Tomislav, Emmert, Hans, Tacke, Josef, Schwalbe, Bernhard, Nam, Eun-Mi, van Lengerich, Ulrike, Lowens, Stephan, Gröschel, Klaus, Uphaus, Timo, Gröschel, Sonja, Boor, Stephan, Dorweiler, Bernhard, Schmid, Elisabeth, Henkes, Hans, Hupp, Thomas, Singer, Oliver, Hamann, Gerhard, Wagner-Heck, Michaela, Kerth-Krick, Sibylle, Kilic, Metin, Huppert, Peter, Niederkorn, Kurt, Fruhwirth, Johannes, Klein, Günther, Pulkowski, Ulrich, Jöster, Karsten, Wacks, Jens-Henning, Kloppmann, Egbert, Vatankhah, Bijan, Hopf-Jensen, Silke, Stolze, Henning, Müller-Hülsbeck, Stefan, Walluscheck, Knut Peer, Schmitt, Hans-Michael, Grüger, Albert, Seemann, Jörg, Tilahun, Belay, Dichgans, Martin, Wollenweber, Frank Arne, Dörr, Angelika, Zollver, Adelgunde, Gäbel, Gabor, Hedtmann, Günter, Kollmar, Rainer, Claus, Detlef, Petermann, Christian, Kirsch, Stefanie, Bosnjak, Branko, Heiß, Johannes, Mühling, Holger, Wunderlich, Silke, Sabisch, Peter Nikolaus, Gahn, Georg, Storck, Martin, Arnold, Sebastian, Fischer, Urs, Gralla, Jan, von Mering, Matthias, Dißmann, Rüdiger, Kirsch, Delia, Schmidauer, Christoph, Waldenberger, Peter, Furtner, Martin, Kazarians, Haiko, Breuer, Peter, Arning, Christian, Rieper, Jürgen, Schmidt, Georg, Arnold, Marcel, Schroth, Gerhard, Weise, Jens, Zanow, Jürgen, Mayer, Thomas, Töpper, Rudolf, Gross-Fengels, Walter, Daum, Harald, Dittrich, Ralf, Ritter, Martin, Kasprzak, Bernd, Torsello, Giovanni, Pohlmann, Carsten, Brüning, Roland, Crispin, Alexander, Hofmann, Miriam, Müller, Thomas, Blessing, Erwin, Möhlenbruch, Markus, Ludwig, Ines, Amiri, Hemasse, Reiff, Tilman, Eckstein, Hans-Henning, Mansmann, Ulrich, Jansen, Olav, Fraedrich, Gustav, Mudra, Harald, Böckler, Dittmar, Böhm, Michael, Debus, E Sebastian, Fiehler, Jens, Mathias, Klaus, Ringelstein, Erich B, Schmidli, Jürg, Stingele, Robert, Zahn, Ralf, Zeller, Thomas, Niesen, Wolf-Dirk, Barlinn, Kristian, Binder, Andreas, Glahn, Jörg, Hacke, Werner, and Ringleb, Peter Arthur

Published
2022
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2. Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial

Author

Reiff, Tilman, primary, Eckstein, Hans-Henning, additional, Mansmann, Ulrich, additional, Jansen, Olav, additional, Fraedrich, Gustav, additional, Mudra, Harald, additional, Böckler, Dittmar, additional, Böhm, Michael, additional, Debus, E Sebastian, additional, Fiehler, Jens, additional, Mathias, Klaus, additional, Ringelstein, Erich B, additional, Schmidli, Jürg, additional, Stingele, Robert, additional, Zahn, Ralf, additional, Zeller, Thomas, additional, Niesen, Wolf-Dirk, additional, Barlinn, Kristian, additional, Binder, Andreas, additional, Glahn, Jörg, additional, Hacke, Werner, additional, Ringleb, Peter Arthur, additional, Beyersdorf, Friedhelm, additional, Macharzina, Roland-Richard, additional, Lechner, Gabriele, additional, Menz, Carolin, additional, Schonhardt, Sabine, additional, Weinbeck, Michael, additional, Greb, Olga, additional, Otto, Dagmar, additional, Winker, Thomas, additional, Berger, Hermann, additional, Poppert, Holger, additional, Kühnl, Andreas, additional, Pütz, Volker, additional, Haase, Kathrin, additional, Bodechtel, Ulf, additional, Weiss, Norbert, additional, Bergert, Hendrik, additional, Meyne, Johannes, additional, Groß, Justus, additional, Kruse, Matthias, additional, Gerdes, Berthold, additional, Reinbold, Wolf-Dieter, additional, Wuttig, Helge, additional, Maier-Hasselmann, Andreas, additional, Segerer, Manuela, additional, Fuchs, Hans-Hermann, additional, Gass, Sabine, additional, Groden, Christoph, additional, Niedergethmann, Marco, additional, Griebe, Martin, additional, Rosenkranz, Michael, additional, Beck, Jürgen, additional, Thomalla, Götz, additional, Zeumer, Hermann H., additional, Jauß, Marek, additional, Kneist, Werner, additional, Kneist, Martina, additional, Staudacher, Thomas, additional, Bernhard, Alfons, additional, Jost, Petra, additional, Prey, Nico, additional, Knippschild, Jürgen, additional, Kastrup, Oliver, additional, Köhrmann, Martin, additional, Frank, Benedikt, additional, Bongers, Volkmar, additional, Hoffmann, Johannes, additional, Kniemeyer, Horst-Wilhelm, additional, Knauth, Michael, additional, Wasser, Kathrin, additional, Stojanovic, Tomislav, additional, Emmert, Hans, additional, Tacke, Josef, additional, Schwalbe, Bernhard, additional, Nam, Eun-Mi, additional, van Lengerich, Ulrike, additional, Lowens, Stephan, additional, Gröschel, Klaus, additional, Uphaus, Timo, additional, Gröschel, Sonja, additional, Boor, Stephan, additional, Dorweiler, Bernhard, additional, Schmid, Elisabeth, additional, Henkes, Hans, additional, Hupp, Thomas, additional, Singer, Oliver, additional, Hamann, Gerhard, additional, Wagner-Heck, Michaela, additional, Kerth-Krick, Sibylle, additional, Kilic, Metin, additional, Huppert, Peter, additional, Niederkorn, Kurt, additional, Fruhwirth, Johannes, additional, Klein, Günther, additional, Pulkowski, Ulrich, additional, Jöster, Karsten, additional, Wacks, Jens-Henning, additional, Kloppmann, Egbert, additional, Vatankhah, Bijan, additional, Hopf-Jensen, Silke, additional, Stolze, Henning, additional, Müller-Hülsbeck, Stefan, additional, Walluscheck, Knut Peer, additional, Schmitt, Hans-Michael, additional, Grüger, Albert, additional, Seemann, Jörg, additional, Tilahun, Belay, additional, Dichgans, Martin, additional, Wollenweber, Frank Arne, additional, Dörr, Angelika, additional, Zollver, Adelgunde, additional, Gäbel, Gabor, additional, Hedtmann, Günter, additional, Kollmar, Rainer, additional, Claus, Detlef, additional, Petermann, Christian, additional, Kirsch, Stefanie, additional, Bosnjak, Branko, additional, Heiß, Johannes, additional, Mühling, Holger, additional, Wunderlich, Silke, additional, Sabisch, Peter Nikolaus, additional, Gahn, Georg, additional, Storck, Martin, additional, Arnold, Sebastian, additional, Fischer, Urs, additional, Gralla, Jan, additional, von Mering, Matthias, additional, Dißmann, Rüdiger, additional, Kirsch, Delia, additional, Schmidauer, Christoph, additional, Waldenberger, Peter, additional, Furtner, Martin, additional, Kazarians, Haiko, additional, Breuer, Peter, additional, Arning, Christian, additional, Rieper, Jürgen, additional, Schmidt, Georg, additional, Arnold, Marcel, additional, Schroth, Gerhard, additional, Weise, Jens, additional, Zanow, Jürgen, additional, Mayer, Thomas, additional, Töpper, Rudolf, additional, Gross-Fengels, Walter, additional, Daum, Harald, additional, Dittrich, Ralf, additional, Ritter, Martin, additional, Kasprzak, Bernd, additional, Torsello, Giovanni, additional, Pohlmann, Carsten, additional, Brüning, Roland, additional, Crispin, Alexander, additional, Hofmann, Miriam, additional, Müller, Thomas, additional, Blessing, Erwin, additional, Möhlenbruch, Markus, additional, Ludwig, Ines, additional, and Amiri, Hemasse, additional

Published
2022
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4. Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma.

Author

Tarun Mehra, Gerd Grözinger, Steven Mann, Emmanuella Guenova, Rudolf Moos, Martin Röcken, Claus Detlef Claussen, Reinhard Dummer, Stephan Clasen, Aline Naumann, and Claus Garbe

Subjects
Medicine, Science
Abstract

Data on survival with mucosal melanoma and on prognostic factors of are scarce. It is still unclear if the disease course allows for mucosal melanoma to be treated as primary cutaneous melanoma or if differences in overall survival patterns require adapted therapeutic approaches. Furthermore, this investigation is the first to present 10-year survival rates for mucosal melanomas of different anatomical localizations.116 cases from Sep 10 1984 until Feb 15 2011 retrieved from the Comprehensive Cancer Center and of the Central Register of the German Dermatologic Society databases in Tübingen were included in our analysis. We recorded anatomical location and tumor thickness, and estimated overall survival at 2, 5 and 10 years and the mean overall survival time. Survival times were analyzed with the Kaplan-Meier method. The log-rank test was used to compare survival times by localizations and by T-stages.We found a median overall survival time of 80.9 months, with an overall 2-year survival of 71.7%, 5-year survival of 55.8% and 10-year survival of 38.3%. The 10-year survival rates for patients with T1, T2, T3 or T4 stage tumors were 100.0%, 77.9%, 66.3% and 10.6% respectively. 10-year survival of patients with melanomas of the vulva was 64.5% in comparison to 22.3% of patients with non-vulva mucosal melanomas.Survival times differed significantly between patients with melanomas of the vulva compared to the rest (p = 0.0006). It also depends on T-stage at the time of diagnosis (p < 0.0001).

Published
2014
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24. Response evaluation of musculoskeletal involvement in patients with deep morphea treated with methotrexate and prednisolone: a combined MRI and clinical approach

Author

Gerhard Fierlbeck, Marius Horger, Jörg Henes, Stefan Schanz, Claus Detlef Claussen, Anja Ulmer, and Ina Kötter

Subjects
Adult, Gadolinium DTPA, Male, medicine.medical_specialty, Prednisolone, Contrast Media, Systemic scleroderma, Scleroderma, Statistics, Nonparametric, Scleroderma, Localized, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Localized Scleroderma, Fasciitis, Glucocorticoids, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Surgery, Tendon sheath, Methotrexate, Treatment Outcome, Female, Dermatologic Agents, business, Morphea, medicine.drug
Abstract

The purpose of this article is to explore the role of MRI in monitoring musculoskeletal involvement in patients with morphea who are undergoing treatment with methotrexate and prednisolone.Twenty-two consecutive patients (six men and 16 women; median age, 52 years) with systemic scleroderma and deep morphea prospectively underwent whole-body MRI twice, before treatment (time 1) and during follow-up after 6-12 months (time 2). Images were evaluated for abnormal signal intensity or thickening of sub-cutaneous fatty tissue septa, muscular fasciae, intramuscular perifascial septa, muscle signal intensity, and articular or tendon sheath synovial abnormalities on STIR and gadolinium-enhanced scans. For clinical assessment, the localized scleroderma (morphea) severity index and a 0-6 pain score were applied.From a clinical point of view, none of our patients had progression of the disease, 12 patients were responders (defined as an improvement of localized scleroderma severity index and pain score ≥ 50%), and 10 patients had stable disease. Among responders, the number of patients with subcutaneous septal thickening (time 1, n = 9; time 2, n = 2), fascial enhancement (time 1, n = 8; time 2, n = 3), and articular synovitis (time 1, n = 5; time 2, n = 1) decreased more than in the stable disease group (subcutaneous septal thickening: time 1, n = 9; time 2, n = 8; fascial enhancement: time 1, n = 5; time 2, n = 5; articular synovitis: time 1, n = 8; time 2, n = 6). Subcutaneous thickening, fascial thickening, and fascial enhancement were scored significantly lower at follow-up MRI in responders.MRI findings were sensitive to changes in musculoskeletal manifestations in patients with deep morphea undergoing systemic treatment with methotrexate and prednisolone. Thus, MRI can be recommended as an additional tool for response monitoring.

Published
2013

26. Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma

Author

Mehra, Tarun, Grözinger, Gerd, Mann, Steven, Guenova, Emmanuella; https://orcid.org/0000-0001-5478-8735, Moos, Rudolf, Röcken, Martin, Claussen, Claus Detlef, Dummer, Reinhard, Clasen, Stephan, Naumann, Aline, Garbe, Claus, Mehra, Tarun, Grözinger, Gerd, Mann, Steven, Guenova, Emmanuella; https://orcid.org/0000-0001-5478-8735, Moos, Rudolf, Röcken, Martin, Claussen, Claus Detlef, Dummer, Reinhard, Clasen, Stephan, Naumann, Aline, and Garbe, Claus

Abstract

BACKGROUND: Data on survival with mucosal melanoma and on prognostic factors of are scarce. It is still unclear if the disease course allows for mucosal melanoma to be treated as primary cutaneous melanoma or if differences in overall survival patterns require adapted therapeutic approaches. Furthermore, this investigation is the first to present 10-year survival rates for mucosal melanomas of different anatomical localizations. METHODOLOGY: 116 cases from Sep 10 1984 until Feb 15 2011 retrieved from the Comprehensive Cancer Center and of the Central Register of the German Dermatologic Society databases in Tübingen were included in our analysis. We recorded anatomical location and tumor thickness, and estimated overall survival at 2, 5 and 10 years and the mean overall survival time. Survival times were analyzed with the Kaplan-Meier method. The log-rank test was used to compare survival times by localizations and by T-stages. PRINCIPAL FINDINGS: We found a median overall survival time of 80.9 months, with an overall 2-year survival of 71.7%, 5-year survival of 55.8% and 10-year survival of 38.3%. The 10-year survival rates for patients with T1, T2, T3 or T4 stage tumors were 100.0%, 77.9%, 66.3% and 10.6% respectively. 10-year survival of patients with melanomas of the vulva was 64.5% in comparison to 22.3% of patients with non-vulva mucosal melanomas. CONCLUSION: Survival times differed significantly between patients with melanomas of the vulva compared to the rest (p = 0.0006). It also depends on T-stage at the time of diagnosis (p < 0.0001).

Published
2014

31. Immune-mediated rippling muscle disease with myasthenia gravis: A report of seven patients with long-term follow-up in two

Author

UCL - Cliniques universitaires Saint-Luc, UCL - MD/NOPS - Département de neurologie et de psychiatrie, UCL - (SLuc) Service de neurologie, Schoser, Benedikt, Van den Bergh, Peter, Jacob, Saiju, Hilton-Jones, David, Mueller-Felber, Wolfgang, Kubisch, Christian, Claus, Detlef, Goebel, Hans H., Vita, Giuseppe, Vincent, Angela, Toscano, Antonio, UCL - Cliniques universitaires Saint-Luc, UCL - MD/NOPS - Département de neurologie et de psychiatrie, UCL - (SLuc) Service de neurologie, Schoser, Benedikt, Van den Bergh, Peter, Jacob, Saiju, Hilton-Jones, David, Mueller-Felber, Wolfgang, Kubisch, Christian, Claus, Detlef, Goebel, Hans H., Vita, Giuseppe, Vincent, Angela, and Toscano, Antonio

Abstract

We report seven patients with immune-mediated rippling muscle disease (iRMD) and AChR-antibody positive myasthenia gravis (MG) without germline caveolin-3 gene mutations. We describe the follow-up of two patients and the clinical features of five new patients (1 female, 4 male, aged 32 to 69 years). These presented with significant generalized, exercise-induced and electrically-silent muscle rippling with rnyalgia, combined with generalized MG. In two of the seven patients, MG appeared before iRMD. Mediastinal imaging excluded thymic alterations in all, although two had other coincident tumours. Myalgia and rippling were aggravated by acetylcholinesterase-inhibitor treatment. Generalized MG and iRMD were Successfully treated with plasma exchange, steroids and azathioprine in the two patients followed long-term. Muscle morphology of five patients showed a minimal myopathic pattern with rare lymphohistiocytic infiltration. In four patients, sarcolemmal caveolin-3, and dysferlin immunofluorescence staining was moderately reduced in a mosaic pattern, but caveolin-3 protein on Western blots was clearly reduced only in two. Notably, electron microscopy showed that caveolae were almost completely lost at the sarcolemma in the three biopsies examined but not in endothelium. Antibodies targeting high molecular weight muscle proteins, likely associated with the neuromuscular endplate and sarcolemma, were found in the iRMD patients but also in age-matched MG patients without iRMD. Since the generalized MG and iRMD improved with immunosuppressive treatments, it is likely that both are caused by autoantibodies, but the target for pathogenic antibodies in iRMD requires further study. (C) 2009 Elsevier B.V. All rights reserved.

Published
2009

38. Socioeconomic burden of amyotrophic lateral sclerosis, myasthenia gravis and facioscapulohumeral muscular dystrophy

Author

Schepelmann, Karsten, primary, Winter, Yaroslav, additional, Spottke, Annika E., additional, Claus, Detlef, additional, Grothe, Christoph, additional, Schröder, Rolf, additional, Heuss, Dieter, additional, Vielhaber, Stefan, additional, Mylius, Veit, additional, Kiefer, Reinhard, additional, Schrank, Bertold, additional, Oertel, Wolfgang H., additional, and Dodel, Richard, additional

Published
2009
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