Search

Background: Sinovac was the first vaccine used in Indonesia against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data regarding the effects of certain variables such as clinical demographics on antibody levels in individuals vaccinated with Sinovac are scarce. This study aimed to investigate the impact of gender and previous SARS-CoV-2 infection status on neutralizing antibody titers 1, 2, and 3 months after administration of the Sinovac vaccine.Method: A cross-sectional study was conducted from February to May 2021. Data on neutralizing antibody levels, previous SARS-CoV-2 infection status, and gender were retrieved from the monthly quantitative serology evaluation database of Siloam Hospitals Lippo Village, Tangerang, Indonesia. The role of each variable was analyzed using the t-test or Mann-Whitney U test, depending on data distribution.Result: Data from 350 participants were collected for the study. Participants with a history of a positive SARS-CoV-2 RT-PCR test had significantly higher neutralizing antibody titers in the first (144 U/mL, p = 0.036) and second months (144 U/mL, p = 0.005) after vaccination compared with those without a history of positive RT-PCR test. Female participants also had significantly higher neutralizing antibody titers in the first, second, and third months (43 U/mL, 42 U/mL, and 39 U/mL, respectively; p = 0.001, p = 0.002, and p = 0.003, respectively) after vaccination compared to males.Conclusion: COVID-19 survivor status and the female gender were associated with higher neutralizing antibody titers after Sinovac vaccine administration.

Currently, there is no widely acceptable and proven effective treatment for coronavirus disease 2019 (COVID‐19). Colchicine has been shown to offer a benefit in reducing the inflammation in several inflammatory diseases. This study aims to analyze the efficacy of colchicine administration and outcomes of COVID‐19. We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until January 29, 2021. All articles published on COVID‐19 and colchicine treatment were retrieved. The quality of the study was assessed using the Newcastle–Ottawa Scale (NOS) tool for observational studies and Revised Cochrane risk‐of‐bias tool for randomized trials (RoB 2) for clinical trial studies. Statistical analysis was done using Review Manager 5.4 software. A total of eight studies with 5778 COVID‐19 patients were included in this meta‐analysis. This meta‐analysis showed that the administration of colchicine was associated with improvement of outcomes of COVID‐19 [OR 0.43 (95% CI 0.34–0.55), p

In light of the current vaccination programs being implemented worldwide, this study aimed to evaluate the determinants of coronavirus disease 2019 (COVID-19) vaccine acceptance in Sumatra, Indonesia. According to a COVID-19 vaccine acceptance survey conducted in Indonesia by the World Health Organization (WHO), the Ministry of Health of the Republic of Indonesia, the National Immunization Technical Advisory Group (NITAG), and the United Nations Children’s Fund (UNICEF), published in November 2020, Sumatra is among the places having lower COVID-19 vaccine acceptance rates, with Aceh Province displaying the lowest level of vaccine acceptance. Thus, a cross-sectional study was conducted, and a logistic regression analysis was used to identify the factors affecting COVID-19 vaccine acceptance. Out of 368 respondents who participated in the survey, 143 (38.9%) accepted the vaccine, and 225 (61.1%) refused it. Vaccine safety concerns constituted the most reported reason for refusal (43.6%). This study also found that province of residence and basic immunization status were determinants of COVID-19 vaccine acceptance in Sumatra. Concerns regarding vaccine safety might be the reason for the low level of vaccination in Sumatra. Increased education and encouragement from healthcare professionals and regional authority figures can alleviate public concerns and improve vaccine acceptance.

The purpose of the current study is to analyze the potential association between viral hepatitis and the severity of COVID-19.Coronavirus disease 2019 (COVID-19) is a worldwide concern that has created major issues with many aspects. It is important to identify the risk factors for severe outcomes of this disease. To date, no association between viral hepatitis and severe COVID-19 has not been established.Through November 5Analysis results included a total of 16 studies with a total of 14,682 patients. Meta-analysis showed that viral hepatitis increases the risk of developing severe COVID-19 (RR 1.68 (95% CI 1.26 - 2.22),An increase of severe COVID-19 risk is associated with viral hepatitis. To reduce the risk of COVID-19, patients with viral hepatitis should be monitored carefully.

Background The preventive measure of Coronavirus Disease pandemic, such as nationwide lockdown, might lead to stress, depression, and anxiety, prominently in adolescents. Many factors were indicated to influence its severity. This study aimed to investigate the magnitude of COVID-19-related mental health problems in adolescents and the associated factors. Methods This cross-sectional study gathered 2018 adolescents throughout Indonesia from April 22nd-28th 2020. The questionnaire was spread through social media and included Kessler-10 Psychological Distress scale and closed-ended questions about the risk and protective factors. The results were analyzed using Mann-Whitney U test, Kruskal-Wallis test, and Logistic Regression. Results The participants were mostly males (91.8%) with a median age of 19. The results showed 54.1% experienced varying degrees of distress. All variables were significantly related with psychological distress during Mann-Whitney-U and Kruskal-Wallis test. The logistic regression analysis showed maintaining or improving dietary pattern and sleep quality was found to be protective against psychological distress (OR = 0.497,95%CI = 0.34-0.725 and OR = 0.515,95%CI = 0.372-0.714, respectively), while others were risk factors, i.e.: Not having a confidant (OR = 1.539,95%CI = 1.226-1.931), frequent argument with parents (OR = 1.735,95%CI = 1.343-2.24), feeling worried (OR = 2.364, 95%CI1.528-3.656), chronic diseases (OR = 2.601,95%CI = 1.468-4.606), and mental illnesses (OR = 9.866,95%CI = 3.855-25.249). Conclusion More than half of adolescents experienced distress. The findings called for initiatives by experts in providing psychosocial support for adolescents.

To control the spread of COVID-19 transmission, Indonesia government has broadcasted information about the pandemic. The aim of this study is to evaluate the understanding of young people, about COVID-19 during the early outbreak in Indonesia. An online-based cross-sectional data collection was conducted from adolescents aged 10 to 25 years, based on 10 questions regarding general COVID-19 information. There were 355 subjects from 25 out of 34 Indonesian provinces who participated in the study, with mean age of 19.93 ± 2.91 years. Better understanding was found in the female and higher-income population. Largely, the subjects got the information from social media, instead of the official government site for COVID-19. Lack of understanding about crucial preventive measures was found, such as handwashing and physical distancing. In conclusion, the participants have an overall moderate-good initial understanding toward COVID-19 during the early outbreak in Indonesia. These results can be used as baseline data for development of awareness measurement tools.

Background: COVID-19 is a respiratory infection caused by SARS CoV-2. A health-related disaster may result in a wide range of mental consequences, including PTSD. IES-R is a self-reported instrument, and it corresponds to DSM-IV symptoms of PTSD. However, there were scarce data about the validation of the Indonesian version of IESR.Aim: The purpose of this study was to validate the IES-R in the Indonesian adult population by comprehensively and systematically assessing the epidemiological evidence about PTSS during the COVID-19 pandemic.Methods: This was a cross-sectional study. The IES-R questionnaire was translated from English to Indonesian, back-translated. All health workers were excluded to avoid the biased result. Pearson correlation and Cronbach's alpha coefficients to determine the validity and reliability of the questionnaire.Results: A total of 234 Indonesian-speaking adults completed the survey. The Indonesian IES-R had proven to be a valid (r= 0.756 -0.938, p= 0.000) and reliable (alpha coefficient: 0.858-0.868) measure for PTSS in a sample of Indonesian adults during the COVID-19 pandemic. In addition, the final model which consisted of 3 subscales with 20 items demonstrated acceptable factor loadings.Conclusion: The results of this study suggested IESR is valid and reliable to be used in the Indonesian population especially during pandemics.

Introduction: Coronavirus Disease 2019 (COVID-19) has become a pandemic. Much false information was circulating especially through social media and affected individual’s knowledge, attitude, practice (KAP) towards COVID-19. Currently, there is lack of validated questionnaires to assess KAP about COVID-19 especially in Indonesian young people.Aim: To develop and validate a new COVID-19 KAP questionnaire for young people population in Indonesian language.Methods: Some literature review was done to look for the concept to generate a new questionnaire. Open-ended questions were generated to know the baseline knowledge. Then, close-ended questions were formulized for knowledge, attitude, and practice area. The experts and several respondents were asked to give their opinions about the contents of the questionnaire. The validity was examined using Cronbach's alpha coefficient. For reliability, internal consistency was examined by using Pearson or Spearmen correlation test.Results: A total of 59 subjects with median ages 21 (16-24) years old of non-medical individuals were included in this validation process. More than half were male, mostly held bachelor’s degree/diploma, and were dominated with students. This Indonesian COVID-19 KAP questionnaire for young people consists of 10 knowledge, 8 attitude, and 7 practice questions. The Cronbach’s alpha coefficient of knowledge, attitude, and practice areas were 0.87, 0.82, and 0.91, respectively.Conclusions: A questionnaire of KAP towards COVID-19 in Indonesian language had been developed and the results showed good validity.

Context: Coronavirus disease 2019 (COVID-19) is a newly discovered disease, caused by SARS-CoV-2 and currently has become a pandemic. Acute respiratory distress syndrome (ARDS) is the most common complication in COVID-19. There were numerous conflicting results among articles related to it. The aim of this study is to ascertain the most compelling evidence about ARDS in COVID-19.Evidence Acquisition: This systematic review was registered in PROSPERO (CRD42020180379). A systematic search was conducted in PubMed, PubMed central, and Google Scholar on April 16, 2020. Two reviewers independently searched and selected the articles. The risk of bias was evaluated using the Newcastle-Ottawa Quality assessment tool.Results: A total of 1,647 articles were screened, 9 articles were included. Patients were classified as having various degrees of ARDS, the diagnosis of COVID-19 was confirmed by PCR nasopharyngeal swab. Risk factors of ARDS in COVID-19 reported were older age, male gender, and pre-existing medical conditions. Cytokine storm was thought to play a role in the mechanism of ARDS. The main treatment for COVID-19 was supportive and symptomatic. To date, there is no antiviral treatment recommended for COVID-19 and the given treatment for ARDS in COVID-19 was similar to other pneumonia-induced ARDS. No additional therapy specific for ARDS in COVID-19 has been proposed.Conclusion: Our synthesis of the literature showed that there was no good evidence in the mechanism and treatment of ARDS. Further translation research in the mechanism of ARDS and continuing with clinical trials evaluating drug efficacy for ARDS in COVID-19 is needed.

Rationale: World health organization (WHO) declared coronavirus disease 2019 (COVID-19) outbreak as a pandemic and many preventive measures were implemented People's adherence to infection control measures is affected by their knowledge, attitudes, and practices (KAP) regarding the disease Currently there is limited data about KAP towards COVID-19 in Indonesian young people population Thereby, the study aims to evaluate healthy lifestyle, as part of the KAP, of the said population during COVID-19 pandemic Methods: This survey was conducted in the second month of COVID-19 outbreak in Indonesia A validated KAP questionnaire was broadcasted through online platforms and answered by young people aged 10-25 KAP questions focusing on healthy lifestyle were extracted from the questionnaire Knowledge and attitude question were asking whether fruit and vegetables consumption was important and may help to strengthen immunity Three practice questions asking if the respondents during quarantine: consumed well-cooked foods (P1), ate vegetables and fruits three times a day (P2), exercised at least 30 minutes per day (P3) The correct KAP answers were described and correlation between KAP were analyzed with Pearson’s correlation test Results: A total of 1,541 respondents of young people completed the questionnaire The median age was 19 (12-25) years old Most respondents were male (n=1,221;79 2%) The highest education background was bachelor’s degree (n=224;14 5%) An average total score of the questionnaire was 69 2 The respondents answered correctly the questions of Knowledge, attitude, practice about healthy lifestyle in 1,539 (99 87%), 1,489 (96 63 %), and 1,523 (98 83 + 48 34 + 49 13%), respectively The knowledge was correlated with attitude (r=0 193, p

Background Chemotherapy, as treatment, may responsible for undesired side effects, such as sarcopenia and chemotherapy toxicity. Based on the previous study, slow muscle mass may increase hematological toxicity and decrease response of chemotherapy effectiveness. The reported data about hematological chemotherapy toxicity and low muscle mass in Indonesian breast cancer patients is very limited thus the aim of this study to find out the prevalence and association between them. Methods This was cross-sectional study, conducted in our general hospital at Tangerang, Indonesia. Muscle mass was measured using Bio Impedance analysis. The first step, Asian Working Group for Sarcopenia (AWGS) criteria is used to count muscle mass cut-off in Indonesian population by height-based muscle mass. AWGS recommends to define low muscle mass as below the mean minus 2 standard deviation. The second step, blood sample from breast cancer patients undergoing chemotherapy were taken consecutively. The cut-off for defining anemia is hemoglobin Results The first step of the study included 137 young adult women. Cut off point of muscle mass in Indonesian female was 4.781 kg/m2. The second step, a total of 36 breast cancer patients with mean age 48.08±9.73 were included. Anemia was found in 20 (54%) subjects, leukopenia in 2 (5.5%) subjects, thrombocytopenia in 1 (2.7%) subject. In this study, patient with low muscle mass only found in 1 of 37 patients. Conclusion Cut-off muscle mass for Indonesian female is 4.781kg/m2, lower than AWGS standard. There is no statistically significant between low muscle mass and hematological toxicity in breast cancer patient. Further study needs to be evaluated in bigger population to confirm this result.