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24 results on '"Claudia Colombo"'

1. Ultrasound-Assisted, Catheter-Directed Thrombolysis for Acute Intermediate/High-Risk Pulmonary Embolism: Design of the Multicenter USAT IH-PE Registry and Preliminary Results

Author

Claudia Colombo, Nicolò Capsoni, Filippo Russo, Mario Iannaccone, Marianna Adamo, Giovanna Viola, Ilaria Emanuela Bossi, Luca Villanova, Chiara Tognola, Camilla Curci, Francesco Morelli, Rossella Guerrieri, Lucia Occhi, Giuliano Chizzola, Antonio Rampoldi, Francesco Musca, Giuseppe De Nittis, Mario Galli, Giacomo Boccuzzi, Daniele Savio, Davide Bernasconi, Luciana D’Angelo, Andrea Garascia, Alaide Chieffo, Matteo Montorfano, Fabrizio Oliva, and Alice Sacco

Subjects
pulmonary embolism, ultrasound assisted, catheter-directed thrombolysis, pulmonary hypertension, Medicine
Abstract

Catheter-based revascularization procedures were developed as an alternative to systemic thrombolysis for patients with intermediate-high- and high-risk pulmonary embolisms. USAT IH-PE is a retrospective and prospective multicenter registry of such patients treated with ultrasound-facilitated, catheter-directed thrombolysis, whose preliminary results are presented in this study. The primary endpoint was the incidence of pulmonary hypertension (PH) at follow-up. Secondary endpoints were short- and mid-term changes in the echocardiographic parameters of right ventricle (RV) function, in-hospital and all-cause mortality, and procedure-related bleeding events. Between March 2018 and July 2023, 102 patients were included. The majority were at intermediate–high-risk PE (86%), were mostly female (57%), and had a mean age of 63.7 ± 14.5 years, and 28.4% had active cancer. Echocardiographic follow-up was available for 70 patients, and in only one, the diagnosis of PH was confirmed by right heart catheterization, resulting in an incidence of 1.43% (CI 95%, 0.036–7.7). RV echocardiographic parameters improved both at 24 h and at follow-up. In-hospital mortality was 3.9% (CI 95%, 1.08–9.74), while all-cause mortality was 11% (CI 95%, 5.4–19.2). Only 12% had bleeding complications, of whom 4.9% were BARC ≥ 3. Preliminary results from the USAT IH-PE registry showed a low incidence of PH, improvement in RV function, and a safe profile.

Published
2024
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2. Effect of landiolol in patients with tachyarrhythmias and acute decompensated heart failure (ADHF): a case series

Author

Valentina Ditali, Laura Garatti, Nuccia Morici, Luca Villanova, Claudia Colombo, Fabrizio Oliva, and Alice Sacco

Subjects
Acute decompensated heart failure, Inotropes, Landiolol, Tachycardia, Tachyarrhythmias, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Tachycardia and rapid tachyarrhythmias are common in acute clinical settings and may hasten the deterioration of haemodynamics in patients with acute decompensated heart failure (ADHF), treated with inotropes. The concomitant use of a short‐acting β1‐selective beta‐blocker, such as landiolol, could rapidly and safely restore an adequate heart rate without any negative inotropic effect. We present a case series of five patients with left ventricular dysfunction, admitted to our Intensive Cardiac Care Unit with ADHF deteriorated to cardiogenic shock, treated with a combination of landiolol and inotropes. Landiolol was effective in terms of rate control and haemodynamics optimization, enabling de‐escalation of catecholamine dosing in all patients. The infusion was always well tolerated without hypotension. In conclusion, a continuous infusion of a low dose of landiolol (3–16 mcg/kg/min) to manage tachycardia and ventricular or supraventricular tachyarrhythmias in haemodynamically unstable patients may be considered.

Published
2022
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3. Left Ventricular Unloading in Acute on Chronic Heart Failure: From Statements to Clinical Practice

Author

Alice Sacco, Nuccia Morici, Jacopo Andrea Oreglia, Guido Tavazzi, Luca Villanova, Claudia Colombo, Laura Garatti, Michele Giovanni Mondino, Stefano Nava, and Federico Pappalardo

Subjects
cardiogenic shock, acute on chronic heart failure, mechanical circulatory support, escalation, Medicine
Abstract

Cardiogenic shock remains a deadly complication of acute on chronic decompensated heart failure (ADHF-CS). Despite its increasing prevalence, it is incompletely understood and therefore often misdiagnosed in the early phase. Precise diagnosis of the underlying cause of CS is fundamental for undertaking the correct therapeutic strategy. Temporary mechanical circulatory support (tMCS) is the mainstay of management: identifying and selecting optimal patients through understanding of the hemodynamics and a prompt profiling and timing, is key for success. A recent statement from the American Heart Association provided pragmatic suggestions on tMCS device selection, escalation, and weaning strategies. However, several areas of uncertainty still remain in clinical practice. Accordingly, we present an overview of the main pitfalls that can occur during patients’ management with tMCS through a clinical case. This case illustrates the strict interdependency between left ventricular unloading and right ventricular dysfunction in the case of low filling pressures. Moreover, it further illustrates the pivotal role of stepwise escalation of therapy in a patient with an ADHF-CS and its peculiarities as compared to other forms of acute heart failure.

Published
2022
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4. Percutaneous Coronary Revascularization after Out-of-Hospital Cardiac Arrest: A Review of the Literature and a Case Series

Author

Francesca Scavelli, Iside Cartella, Claudio Montalto, Jacopo Andrea Oreglia, Luca Villanova, Laura Garatti, Claudia Colombo, Alice Sacco, and Nuccia Morici

Subjects
out-of-hospital cardiac arrest, percutaneous coronary revascularization, no ST-segment elevation, Medicine
Abstract

Out-of-hospital cardiac arrest (OHCA) is still associated with high mortality and severe complications, despite major treatment advances in this field. Ischemic heart disease is a common cause of OHCA, and current guidelines clearly recommend performing immediate coronary angiography (CAG) in patients whose post-resuscitation electrocardiogram shows ST-segment elevation (STE). Contrarily, the optimal approach and the advantage of early revascularization in cases of no STE is less clear, and decisions are often based on the individual experience of the center. Numerous studies have been conducted on this topic and have provided contradictory evidence; however, more recently, results from several randomized clinical trials have suggested that performing early CAG has no impact on overall survival in patients without STE.

Published
2022
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5. Inflammation and Coronary Microvascular Dysfunction in Autoimmune Rheumatic Diseases

Author

Elisabetta Zanatta, Claudia Colombo, Gianpiero D’Amico, Thomas d’Humières, Carlo Dal Lin, and Francesco Tona

Subjects
autoimmune diseases, inflammation, coronary microcirculation, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Autoimmune rheumatic diseases (ARDs) form a heterogeneous group of disorders that include systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA), idiopathic inflammatory myopathies (IIMs), and systemic vasculitis. Coronary microvascular dysfunction (CMD) is quite common in patients with ARDs and is linked to increased cardiovascular morbidity and mortality. Inflammation plays a crucial role in the pathogenesis of both accelerated atherosclerosis and CMD in ARDs, especially in patients affected by SLE and RA. In this regard, some studies have highlighted the efficacy of immunosuppressants and/or biologics in restoring CMD in these patients. By contrast, the role of inflammation in the pathogenesis of CMD-SSc appears to be much less relevant compared to endothelial dysfunction and microvascular ischemia, with calcium-channel blockers providing some benefits. Few studies have endeavored to assess the occurrence of CMD in IIMs and systemic vasculitis, thus warranting further investigations. The present review summarizes the current evidence on the occurrence of CMD in ARDs, focusing on the role of inflammation and possible therapeutic approaches.

Published
2019
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6. Suburban waterfront with ecological and recreational function: planning based on network analysis

Author

Natalia Fumagalli, Claudia Colombo, Paolo Stefano Ferrario, Giulio Senes, and Alessandro Toccolini

Subjects
land use planning, ecological network, geographical information systems., Agriculture, Agriculture (General), S1-972
Abstract

Urban fringe areas have multiple land uses and are places where sections of waterway, together with fragmented areas of natural vegetation, are often found passing through urban areas, transportation routes and gradually expanding rural areas. These overlapping functions are often the cause of an extremely disorderly landscape devoid of guiding connotative elements. In this context, the waterfront can be a guiding element for the redevelopment of the fringe areas between cities and the countryside. The purpose of this paper is the definition of a methodology for planning a suburban waterfront with an ecological function and bicycle paths for recreational use. The evaluation phases for resources and planning, conducted with tools for network analysis, have identified potential corridors based on current land uses and have addressed the issue of bicycle paths on an inter-municipal scale. The methodology is proposed for regional level planning and the validation of the method was achieved through its application to the stretch of the Lambro River between Monza Park and the city of Milan in the North of Italy.

Published
2014
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7. Effect of a quality-improvement intervention on end-of-life care in cardiac intensive care unit

Author

Alice Sacco, Giovanni Tavecchia, Valentina Ditali, Laura Garatti, Luca Villanova, Claudia Colombo, Giovanna Viola, Francesca Scavelli, Marisa Varrenti, Martina Milani, Nuccia Morici, Guido Tavazzi, Barbara Lissoni, Lorena Forni, Giovanna Gorni, Giorgia Saporetti, Fabrizio Oliva, Sacco, A, Tavecchia, G, Ditali, V, Garatti, L, Villanova, L, Colombo, C, Viola, G, Scavelli, F, Varrenti, M, Milani, M, Morici, N, Tavazzi, G, Lissoni, B, Forni, L, Gorni, G, Saporetti, G, and Oliva, F

Subjects
cardiac intensive care unit, palliative care, Clinical Biochemistry, heart failure, General Medicine, Biochemistry, therapeutic limitation
Published
2023

8. Effect of landiolol in patients with tachyarrhythmias and acute decompensated heart failure (ADHF): a case series

Author

Valentina Ditali, Laura Garatti, Nuccia Morici, Luca Villanova, Claudia Colombo, Fabrizio Oliva, and Alice Sacco

Subjects
Tachycardia, RC666-701, Inotropes, Diseases of the circulatory (Cardiovascular) system, Case Report, Acute decompensated heart failure, Landiolol, Tachyarrhythmias, Cardiology and Cardiovascular Medicine
Abstract

Tachycardia and rapid tachyarrhythmias are common in acute clinical settings and may hasten the deterioration of haemodynamics in patients with acute decompensated heart failure (ADHF), treated with inotropes. The concomitant use of a short‐acting β1‐selective beta‐blocker, such as landiolol, could rapidly and safely restore an adequate heart rate without any negative inotropic effect. We present a case series of five patients with left ventricular dysfunction, admitted to our Intensive Cardiac Care Unit with ADHF deteriorated to cardiogenic shock, treated with a combination of landiolol and inotropes. Landiolol was effective in terms of rate control and haemodynamics optimization, enabling de‐escalation of catecholamine dosing in all patients. The infusion was always well tolerated without hypotension. In conclusion, a continuous infusion of a low dose of landiolol (3–16 mcg/kg/min) to manage tachycardia and ventricular or supraventricular tachyarrhythmias in haemodynamically unstable patients may be considered.

Published
2021

9. The impact of transcatheter edge-to-edge repair on right ventricle-pulmonary artery coupling in patients with functional mitral regurgitation

Author

Lorenzo Tua, Alessandro Mandurino‐Mirizzi, Claudia Colombo, Nuccia Morici, Giulia Magrini, Stefano Nava, Romina Frassica, Claudio Montalto, Marco Ferlini, Alice Sacco, Francesco Musca, Antonella Moreo, Stefano Ghio, Jacopo Oreglia, Luigi Oltrona‐Visconti, Fabrizio Oliva, and Gabriele Crimi

Subjects
Heart Valve Prosthesis Implantation, Cardiac Catheterization, Treatment Outcome, Heart Ventricles, Clinical Biochemistry, Humans, Mitral Valve Insufficiency, General Medicine, Pulmonary Artery, Biochemistry
Published
2022

11. Internet addiction and criminal phenomenology: an insight on the Social Networking Sites addiction and the online death games

Author

Claudia Colombo and Monica Calderaro

Subjects
General Medicine
Abstract

With the advent of the virtual world as the counterpart of our daily lives, several concerns emerged. The following paper will focus on the iGeneration, a fragile social group grown up between the online and the offline world, and its chances to develop a technology addiction. Secondly, an insight on the illustrative and extreme scenario of the Blue Whale Challenge, a death challenge emerged on social networking sites, its implications and connection with the real world.

Published
2021

13. Meta-Analysis of the Optimal Percutaneous Revascularization Strategy in Patients With Acute Myocardial Infarction, Cardiogenic Shock, and Multivessel Coronary Artery Disease

Author

Paola Tellaroli, Claudia Colombo, Sorin J. Brener, Gianpiero D'Amico, and Giuseppe Tarantini

Subjects
medicine.medical_specialty, medicine.medical_treatment, Myocardial Infarction, Shock, Cardiogenic, Coronary Artery Disease, 030204 cardiovascular system & hematology, Revascularization, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Percutaneous Coronary Intervention, Internal medicine, medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Myocardial infarction, Practice Guidelines as Topic, Cardiology and Cardiovascular Medicine, business.industry, Cardiogenic shock, Percutaneous coronary intervention, Shock, Odds ratio, Cardiogenic, medicine.disease, Confidence interval, Surgery, Conventional PCI, Cardiology, business
Abstract

The optimal percutaneous coronary intervention (PCI) revascularization strategy in patients with multivessel (MV) coronary artery disease (CAD) who present with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) has not been systematically addressed. Accordingly, we performed a study-level meta-analysis comparing 2 PCI strategies in these patients—infarct-related artery (IRA) only versus MV revascularization. Studies including patients with AMI and MV CAD complicated with CS who received primary PCI were searched from 2000 to 2016. The primary end points were in-hospital/30-day and mid- to long-term (≥6 month) mortality. Fixed and random effects models were used for analysis. Ten studies (9 prospective and 1 retrospective) involving 6,068 patients met our inclusion criteria. IRA-only PCI was the most frequently used revascularization strategy (4,872 patients, 80%), while MV PCI was performed in 1,196 patients (20%). The MV PCI strategy was associated with higher short-term mortality compared with the IRA-only PCI strategy (odds ratio 1.41, 95% confidence interval 1.15 to 1.71, p = 0.008). There was no difference in mid- to long-term mortality between MV PCI and IRA-only strategies (odds ratio 1.02, 95% confidence interval 0.65 to 1.58, p = 0.94). In conclusion, in patients with AMI and MV CAD complicated by CS, the IRA-only PCI strategy seems to be associated with lower short-term, but not mid- to long-term mortality compared with MV PCI. This finding is different from the revascularization strategy recommended by current professional guidelines and suggests the need for dedicated randomized clinical trials.

Published
2016

14. Cloning and functional expression of intracellular loop variants of the honey bee (Apis mellifera) RDL GABA receptor

Author

Isabel Bermudez, Joseph Hawkins, Andrew K. Jones, Claudia Colombo, and Jennina Taylor-Wells

Subjects
0301 basic medicine, Agonist, Insecticides, medicine.drug_class, Xenopus, Biology, Toxicology, Insecticide Resistance, 03 medical and health sciences, chemistry.chemical_compound, Neonicotinoids, Xenopus laevis, GABA receptor, Receptors, GABA, Complementary DNA, Botany, medicine, Animals, Protein Isoforms, GABA Agonists, Fipronil, gamma-Aminobutyric Acid, Dieldrin, General Neuroscience, Alternative splicing, Bees, biology.organism_classification, Nitro Compounds, Cell biology, 030104 developmental biology, chemistry, RNA splicing, Oocytes, Insect Proteins, Pyrazoles, Intracellular
Abstract

The insect GABA receptor, RDL (resistance to dieldrin), plays central roles in neuronal signalling and is the target of several classes of insecticides. To study the GABA receptor from an important pollinator species, we cloned Rdl cDNA from the honey bee, Apis mellifera. Three Rdl variants were identified, arising from differential use of splice acceptor sites in the large intracellular loop between transmembrane regions 3 and 4. These variants were renamed from previously, as Amel_RDLvar1, Amel_RDLvar2 and Amel_RDLvar3. When expressed in Xenopus laevis oocytes, the three variants showed no difference in sensitivity to the agonist, GABA, with EC50s of 29 μM, 20 μM and 29 μM respectively. Also, the potencies of the antagonists, fipronil and imidacloprid, were similar on all three variants. Fipronil IC50 values were 0.18 μM, 0.31 μM and 0.20 μM whereas 100 μM imidacloprid reduced the GABA response by 17%, 24% and 31%. The possibility that differential splicing of the RDL intracellular loop may represent a species-specific mechanism leading to insensitivity to insecticides is discussed.

Published
2015

15. Platinum, palladium and rhodium release from vehicle exhaust catalysts and road dust exposed to simulated lung fluids

Author

Jane A. Plant, Claudia Colombo, and A. John Monhemius

Subjects
Health, Toxicology and Mutagenesis, chemistry.chemical_element, Models, Biological, Risk Assessment, Catalysis, Rhodium, Interstitial fluid, Humans, Lung, Platinum, Vehicle Emissions, Inhalation exposure, Air Pollutants, Inhalation Exposure, Inhalation, Extraction (chemistry), Metallurgy, Public Health, Environmental and Occupational Health, Dust, Extracellular Fluid, General Medicine, Pollution, chemistry, Environmental chemistry, Palladium
Abstract

The risk associated with the inhalation of platinum group element (PGE) emissions from vehicle exhaust catalysts (VECs) has been investigated by extracting road dust and milled auto catalyst with simulated lung fluids. Gamble's solution (representative of the interstitial fluid of the deep lung) and artificial lysosomal fluid (ALF) (representative of the more acidic environment within the lung) were employed as extraction fluids. The highest PGE release was observed in ALF, implying that inhaled particles would have to be phagocytized before significant amounts of PGEs dissolve. The greatest percentage (up to 88%) of PGEs was released from road dust, possibly due to the presence of mobile PGE species formed in the roadside environment. Pt showed the highest absolute bioavailability, due to its greater concentration in the environmental samples. Pd and Rh had higher percentage of release, however, because of their more soluble nature. From the toxicological perspective, the results demonstrate potential health risks due to the likely formation of PGE-chloride complexes in the respiratory tract, such species having well-known toxic and allergenic effects on human beings and living organisms.

Published
2008

16. The estimation of the bioavailabilities of platinum, palladium and rhodium in vehicle exhaust catalysts and road dusts using a physiologically based extraction test

Author

Jane A. Plant, A. John Monhemius, and Claudia Colombo

Subjects
Environmental Engineering, Stereochemistry, Biological Availability, chemistry.chemical_element, Models, Biological, Catalysis, Rhodium, Humans, Environmental Chemistry, Toxicokinetics, Solubility, Waste Management and Disposal, Platinum, Vehicle Emissions, Gastric Juice, Chemistry, Extraction (chemistry), Dust, Pollution, Bioavailability, Gastrointestinal Tract, Environmental chemistry, Environmental Pollutants, Palladium, Environmental Monitoring
Abstract

Platinum group element (PGE) levels in the environment have increased following the introduction of vehicle exhaust catalysts (VECs). In order to evaluate the potential pathways of PGEs from VECs into humans, a physiologically based extraction test (PBET) was used to study the uptake of PGEs by the human digestive tract. The PBET assay was implemented in two phases, to first simulate the passage of ingested soil through the acid conditions of the stomach before it enters the near neutral conditions of the small intestine. The results showed that Pt, Pd and Rh did not undergo precipitation reaction when passing from the acid environment of the stomach to the neutral environment of the small intestine. The greatest fractions of bioavailable PGEs (up to 68%) were observed in road dust samples, possibly due to the presence of mobile PGE species formed in the roadside environment. Higher percentages of Pd and Rh were bioavailable than Pt, probably due to the differences in their mobilities and tendencies to form soluble complexes. Pt showed the highest absolute bioavailability however, due to its greater concentration in environmental samples. The solubilization of PGEs in the human digestive tract could involve the formation of PGE-chloride complexes, with perhaps increased health-hazard issues because of the known toxic and allergenic effects of these species.

Published
2008

17. Componentes para diagnóstico de Síndrome Metabólica pelo NCEP-ATP III em uma população afro-brasileira

Author

Maurer, Patrícia, primary, Gullich, Angelica Aparecida da Costa, additional, Retamoso, Vanessa Rosa, additional, Freitas, Eva Ribeiro Villanova de, additional, Bruno, Jamila Benvegnu, additional, Berro, Lyana Feijoo, additional, Oliveira, Ana Claudia Colombo de, additional, Moresco, Rafael Noal, additional, Sauzem, Patricia Dutra, additional, Manfredini, Vanusa, additional, Machado, Michel Mansur, additional, and Piccoli, Jacqueline da Costa Escobar, additional

Published
2017
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18. Plasma-induced graft-polymerization of polyethylene glycol acrylate on polypropylene films: Chemical characterization and evaluation of the protein adsorption

Author

Pietro Gatti-Lafranconi, Elisa Grimoldi, Marina Lotti, Stefano Zanini, Silvia Maria Doglia, Anna Villa, Antonino Natalello, Claudia Colombo, Cristina Riccardi, Zanini, S, Riccardi, C, Grimoldi, E, Colombo, C, Villa, A, Natalello, A, GATTI LANFRANCONI, P, Lotti, M, and Doglia, S

Subjects
Materials science, Surface Properties, Analytical chemistry, Polyethylene glycol, Polypropylenes, Polyethylene Glycols, Biomaterials, chemistry.chemical_compound, Colloid and Surface Chemistry, Adsorption, Proteins adsorption, Fourier transform infrared spectroscopy, Polypropylene, chemistry.chemical_classification, Proteins, Polymer, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Graft copolymer, Acrylates, chemistry, Polymerization, Attenuated total reflection, Cold plasma, Biocompatibility, Nuclear chemistry, Protein adsorption
Abstract

This work deals with the optimization of argon plasma-induced graft-polymerization of polyethylene glycol acrylate (PEGA) on polypropylene (PP) films in order to obtain surfaces with a reduced protein adsorption for possible biomedical applications. To this end, we examined the protein adsorption on the treated and untreated surfaces. The graft-polymerization process consisted of four steps: (a) plasma pre-activation of the PP substrates; (b) immersion in a PEGA solution; (c) argon plasma-induced graft-polymerization; (d) washing and drying of the samples. The efficiency of these processes was evaluated in terms of the amount of grafted polymer, coverage uniformity and substrates wettability. The process was monitored by contact angle measurements, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), X-ray Photoelectron Spectroscopy (XPS) and atomic force microscopy (AFM) analyses. The stability of the obtained thin films was evaluated in water and in Phosphate Buffer Saline (PBS) at 37 °C. The adsorption of fibrinogen and green fluorescent protein (GFP) – taken as model proteins – on the differently prepared surfaces was evaluated through a fluorescence approach using laser scanning confocal microscopy with photon counting detection. After plasma treatments of short duration, the protein adsorption decreases by about 60–70% with respect to that of the untreated film, while long plasma exposure resulted in a higher protein adsorption, due to damaging of the grafted polymer.

Published
2010

19. Plasma-induced graft-polymerization of polyethylene glycol acrylate on polypropylene substrates

Author

Claudia Colombo, Stefano Zanini, Elisa Grimoldi, Marco Orlandi, Cristina Riccardi, Zanini, S, Orlandi, M, Colombo, C, Grimoldi, E, and Riccardi, C

Subjects
Polypropylene, chemistry.chemical_classification, Acrylate, Materials science, technology, industry, and agriculture, Polyethylene glycol, Polymer, Atomic and Molecular Physics, and Optics, Contact angle, chemistry.chemical_compound, Chemical engineering, chemistry, Polymerization, Attenuated total reflection, High-frequency and RF discharges, Polymers on surface, CHIM/06 - CHIMICA ORGANICA, adhesion, Plasma-based ion implantation and deposition, Surface modification
Abstract

A detailed study of argon plasma-induced graft-polymerization of polyethylene glycol acrylate (PEGA) on polypropylene (PP) substrates (membranes and films) is presented. The process consists of four steps: (a) plasma pre-activation of the PP substrates; (b) immersion in a PEGA solution; (c) argon plasma-induced graft-polymerization; (d) washing and drying of the samples. Influence of the solution and plasma parameters on the process efficiency evaluated in terms of amount of grafted polymer, coverage uniformity and substrates wettability, are investigated. The plasma-induced graft-polymerization of PEGA is then followed by sample weighting, water droplet adsorption time and contact angle measurements, attenuated total reflection infrared spectroscopy (ATR-IR), X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) analyses. The stability of the obtained thin films was evaluated in water and in phosphate buffer saline (PBS) at 37 °C. Results clearly indicates that plasma-induced graft-polymerization of PEGA is a practical methodology for anti-fouling surface modification of materials.

Published
2009

20. Plasma-induced graft-polymerization of ethylene glycol methacrylate phosphate on polyethylene films

Author

Fabrizio Croccolo, Claudia Colombo, Stefano Zanini, Marco Orlandi, Cristina Riccardi, Zanini, S, Riccardi, C, Orlandi, M, Colombo, C, and Croccolo, F

Subjects
chemistry.chemical_classification, Materials science, Polymers and Plastics, Plasma parameters, Polymer, Polyethylene, Condensed Matter Physics, grafting, Limiting oxygen index, Contact angle, chemistry.chemical_compound, FIS/01 - FISICA SPERIMENTALE, chemistry, X-ray photoelectron spectroscopy, Polymerization, Mechanics of Materials, Attenuated total reflection, Polymer chemistry, Materials Chemistry, PE, plasma, FIS/03 - FISICA DELLA MATERIA, Nuclear chemistry
Abstract

A detailed study of argon plasma-induced graft-polymerisation of ethylene glycol methacrylate phosphate (EGMP) on polyethylene (PE) substrates is presented. The process consists of four steps: (a) plasma pre-activation of the PE substrates; (b) immersion in an EGMP solution; (c) argon plasma-induced graft-polymerisation; (d) washing and drying of the samples. Influence of the solution and plasma parameters on the process efficiency, evaluated in terms of amount of grafted polymer and coverage uniformity, is investigated. The plasma-induced graft-polymerisation of EGMP is then followed by sample weighting, contact angle measurements, attenuated total reflection infrared (ATR-IR) spectroscopy and X-ray photoelectron spectroscopic (XPS) analysis. Finally, flame-retardant properties of modified PE substrates are evaluated by limiting oxygen index (LOI) measurements. © 2008 Elsevier Ltd. All rights reserved.

Published
2008

21. Photochemical reduction of oxygen adsorbed to nanocrystalline TiO(2) films: a transient absorption and oxygen scavenging study of different TiO(2) preparations

Author

Gerry Doyle, Claudia Colombo, Ana M. Peiró, and Andrew Mills, James R. Durrant, and Jenny Nelson

Subjects
Anatase, Materials science, Kinetics, chemistry.chemical_element, Photochemistry, Oxygen, Nanocrystalline material, Surfaces, Coatings and Films, chemistry.chemical_compound, Adsorption, chemistry, Rutile, Titanium dioxide, Materials Chemistry, Photocatalysis, Physical and Theoretical Chemistry
Abstract

Transient absorption spectroscopy (TAS) has been used to study the interfacial electron-transfer reaction between photogenerated electrons in nanocrystalline titanium dioxide (TiO(2)) films and molecular oxygen. TiO(2) films from three different starting materials (TiO(2) anatase colloidal paste and commercial anatase/rutile powders Degussa TiO(2) P25 and VP TiO(2) P90) have been investigated in the presence of ethanol as a hole scavenger. Separate investigations on the photocatalytic oxygen consumption by the films have also been performed with an oxygen membrane polarographic detector. Results show that a correlation exists between the electron dynamics of oxygen consumption observed by TAS and the rate of oxygen consumption through the photocatalytic process. The highest activity and the fastest oxygen reduction dynamics were observed with films fabricated from anatase TiO(2) colloidal paste. The use of TAS as a tool for the prediction of the photocatalytic activities of the materials is discussed. TAS studies indicate that the rate of reduction of molecular oxygen is limited by interfacial electron-transfer kinetics rather than by the electron trapping/detrapping dynamics within the TiO(2) particles.

Published
2006

22. Suburban waterfront with ecological and recreational function: planning based on network analysis

Author

N. Fumagalli, Giulio Senes, A. Toccolini, Claudia Colombo, and P. Ferrario

Subjects
Functional ecology, Land use, Mechanical Engineering, lcsh:S, Bioengineering, Land-use planning, Context (language use), lcsh:S1-972, Civil engineering, Industrial and Manufacturing Engineering, Ecological network, lcsh:Agriculture, land use planning, ecological network, geographical information systems, Geography, Redevelopment, lcsh:Agriculture (General), Rural area, Recreation, Environmental planning
Abstract

Urban fringe areas have multiple land uses and are places where sections of waterway, together with fragmented areas of natural vegetation, are often found passing through urban areas, transportation routes and gradually expanding rural areas. These overlapping functions are often the cause of an extremely disorderly landscape devoid of guiding connotative elements. In this context, the waterfront can be a guiding element for the redevelopment of the fringe areas between cities and the countryside. The purpose of this paper is the definition of a methodology for planning a suburban waterfront with an ecological function and bicycle paths for recreational use. The evaluation phases for resources and planning, conducted with tools for network analysis, have identified potential corridors based on current land uses and have addressed the issue of bicycle paths on an inter-municipal scale. The methodology is proposed for regional level planning and the validation of the method was achieved through its application to the stretch of the Lambro River between Monza Park and the city of Milan in the North of Italy.

Published
2014

23. Incidence and Recurrence of Portal Vein Thrombosis in Cirrhotic Patients

Author

Violi, F., Corazza, G. R., Caldwell, S. H., Talerico, G., Romiti, G. F., Napoleone, L., Perticone, F., Bolondi, L., Pietrangelo, A., Vestri, A. R., Raparelli, V., Basili, S., Elena, A. M., Paola, A., Angelo, A., Bottino, Francesco, Mario, A., Antonio, F., Massimiliano, A., Umberto, A., Maurizio, A., Milena, B., Cristina, B., Gaetano, B., Michele, B., Battista, B. G., Ilaria, B. P., Benedetta, B., Giancarlo, B., Christian, B., Silvia, B., Agostino, B., Carmelo, B., Buzzetti, E., Irene, C., Stefano, C., Roberto, C., William, C., Santagati, Federica, Isabella, C., Pietro, C., Benedetto, C., Domenica, C. M., Luigi, C., Maurizio, C., Lara, C., Flavio, C., Sebastiano, C., Claudia, C., Maria, C. B., Elena, C., Amato, Salvatore, Giorgio, C., Filippo, C., Giuseppe, C., Chiara, C., Valentina, C., Felicia, D., Gennaro, D., Roberto, D. F., Alfredo, D. G., Stefano, D. V., Wilma, D. V., Maria, D. B., Lisette, D. C., Giuseppe, D., Andrea, D., Valentina, D. C., Paolo, D. G., Dario, D. M., Giovanni, D. M., Emilia, D., Davide, D., Emanuele, D. -M., Falsetti, L., Alessio, F., Vincenza, F., Silvano, F., Giovanni, F., Tiziana, F., Alessandra, F., Pierluigi, F., Giovanni, G., Vigneri, Paolo, Matteo, G., Ruggiero, G., Antonio, G., Angelo, G., Antonina, G., Gianluigi, G., Alessandro, G., Davide, G., Daniel, H., Angelo, I., Luigi, I., Pietro, I., Antonio, I., Giacomo, L., Anna, L., Livia, L. M., Giusi, L., Sergio, M., Roberto, M., Matteo, M., Alessandra, M., Sara, M., Maria, M. A., Pio, M. G., Maristella, M., Michela, M., Antonio, M., Giuseppe, M., Ludovico, M. A., Ignazio, M., Olivia, M., Paola, N., Sergio, N., Grazia, N., Lorenzo, N., Donatella, P., Giuseppe, P., Ostilio, P. V., Daniele, P., Francesca, P., Maria, P., Paola, P., Luigi, P., Irene, P., Salvatore, P., Antonio, P., Serena, P. F., Pietro, P., Pasquale, P., Miriam, P., Daniela, P., Licia, P., Vincenzo, P., Graziella, P., Giacomo, P., Francesco, P., Enrico, R., Giovanni, R., Tea, R., Laura, R., Mario, R., Isabel, R. -C. K., Giulio, R. R., Eleonora, R., David, S., Francesco, S., Aldo, S., Andrea, S., Giuseppe, S., Claudia, S., Francesca, S., Daniela, S., Cosima, S., Roberto, S., Marco, S., Carla, S., Gaetano, S., Domenico, S., Maurizio, S., Nicolo, S., Silvia, S., Orietta, S., Stasi, C., Patrizia, S., Gianluca, S. B., Michela, T., Claudio, T., Joseph, T. E., Tommaso, T., Filippo, T., Daniele, T., Matteo, T., Giovanni, T., Antonella, T., Antonino, T., Doriana, V., Natale, V., Rita, V. C., Gianluigi, V., Paolo, V., Umberto, V. -G., Elia, V., Gianpaolo, V., Villani, R., Ronca, V., Giacomo, V., Francesco, V., Assunta, Z. M., Paolo, P., Marco, P., and Francesco Violi, Gino Roberto Corazza, Stephen H. Caldwell, Giovanni Talerico, Giulio Francesco Romiti, Laura Napoleone, Francesco Perticone, Luigi Bolondi, Antonello Pietrangelo, Anna Rita Vestri, Valeria Raparelli, Stefania Basili, Ainora Maria Elena, Andreozzi Paola, AndriulliAngelo,Angelico Francesco, Angelico Mario, Figliomeni Antonio, Anzaldi Massimiliano, Arena Umberto, Averna Maurizio, Barone Milena, Bazzini Cristina, Bergamaschi Gaetano, Bertoni Michele, Bianchi, Giovanni Battista, Bianchi Paola Ilaria, Boari Benedetta, Bombonato Giancarlo, Bracco Christian, Brocco Silvia, Buonauro, Agostino, Buttà Carmelo, Buzzetti Elena, Cacciola Irene, Calabria Stefano, Cangemi Roberto, Capeci William, Caradio, Federica, Carderi Isabella, Carleo Pietro, Caroleo Benedetto, Carrabba Maria Domenica, Castorani Luigi, Cavallo Maurizio, Cecchetto Lara, Cesaro Flavio, Cicco Sebastiano, Cimini Claudia, Colombo Barbara Maria, Corradini Elena, Corrao Salvatore, Costantino Giorgio, Costanzo Filippo, Croce Giuseppe, Cuoghi Chiara, Curigliano Valentina, D’Alitto Felicia, D’Amico Gennaro, De Franchis Roberto, De Giorgi Alfredo, De Vuono Stefano, Debernardi Venon Wilma, Del Ben Maria, Del Corso Lisette, Delitala Giuseppe, Denegri Andrea, Di Cesare Valentina, Di Giosia Paolo, Di Michele Dario, Di Minno Giovanni, Donnarumma Emilia, Drenaggi Davide, Durante-Mangoni Emanuele, Falsetti Lorenzo, FarcomeniAlessio, FarinaroVincenza, Fasolato Silvano, Ferrari Giovanni, Fierro Tiziana, Forgione Alessandra, Frugiuele Pierluigi, Galati Giovanni, Gallo Paolo, Garcovich Matteo, Gargano Ruggiero, Gasbarrini Antonio, Gatta Angelo, Giammanco Antonina, Giannelli Gianluigi, Giorgini Paolo, Gobbi Paolo, Granito Alessandro, GrassiDavide, Greco Antonio, Grembiale Alessandro, Gresele Paolo, Hijazi Daniel, Iacobellis, Angelo, Iamele Luigi, Invernizzi Pietro, Ippolito Antonio, Laffi, Giacomo, Licata Anna, Liguori Maria Livia, Lorusso Giusi, Maimone Sergio, Manfredini Roberto, Marcacci Matteo, Marchese Alessandra, Marinelli Sara, Marra Alberto Maria, Martino Giuseppe Pio, Masala Maristella, Masotti Michela, Merla Antonio, Miceli Giuseppe, Montebianco Abenavoli Ludovico, Morana Ignazio, Morelli Olivia, Murgia Giuseppe, Naccarato Paola, Neri Sergio, Niro Grazia, Nobili Lorenzo, Padula Donatella, PalascianoGiuseppe, PalmieriVincenzoOstilio, PastoriDaniele, Pattoneri Paolo, Perego Francesca, Perticone Maria, Pesce Paola, Petramala Luigi, Pettinari Irene, Piano Salvatore, Picardi Antonio, Pignataro Francesca Serena, Pignataro Pietro, Pignatelli Pasquale, PinnaMiriam, Pinto Antonio, Pinto Daniela, Polimeni Licia, Pretti Vincenzo, Privitera Graziella, Proietti Marco, Pucci Giacomo, Purrello Francesco, Ragone Enrico, Raimondo Giovanni, Restuccia Tea, Riccardi Laura, RizzettoMario, Rodríguez- Castro Kryssia Isabel, Romanelli Roberto Giulio, Ruscio Eleonora, Sacerdoti David, Salinaro Francesco, Salvi Aldo, Salzano Andrea, SantangeloGiuseppe, Santarossa Claudia, Santilli Francesca, Santovito Daniela, Scarpini Francesca, Schiavone Cosima, Scicali Roberto, SenzoloMarco, Serra Carla, Serviddio Gaetano, Sirico Domenico, Soresi Maurizio, Sperduti Nicolò, Staffolani Silvia, Staltari Orietta, Stasi Cristina, Suppressa Patrizia, Svegliati Baroni Gianluca, Talia Michela, Tana Claudio, Tassone Eliezer Joseph, Todisco Tommaso, Toriello Filippo, Torres Daniele, Traversa Matteo, Tripepi Giovanni, Tufano Antonella, Tuttolomondo Antonino, Varvara Doriana, Vazzana Natale, Vecchio Claudia Rita, Vendemiale Gianluigi, Ventura Paolo, Vespasiani-Gentilucci Umberto, Vettore Elia, Vidili Gianpaolo, Villani Rosanna, Vincenzo Ronca, Visioli Giacomo, Vitale Francesco, Zocco Maria Assunta.

Subjects
Liver Cirrhosis, Male, medicine.medical_specialty, Letter to the editor, Time Factors, MEDLINE, Portal Vein Thrombosis Cirrhotic Patients, outcomes, NO, coagulopathy, Recurrence, Risk Factors, Medicine, Humans, Aged, Female, Incidence, Italy, Middle Aged, Prospective Studies, Registries, Ultrasonography, Doppler, Venous Thrombosis, Portal Vein, portal vein thrombosis, Prospective cohort study, risk-factors, liver-transplantation, mortality, Ultrasonography, business.industry, Incidence (epidemiology), portal vein thrombosis, liver-transplantation, risk-factors, coagulopathy, mortality, outcomes, Doppler, Hematology, medicine.disease, Portal vein thrombosis, Radiology, business
Abstract

Cirrhosis has been long considered a risk factor for bleeding due to the co-existence of the so-called ‘coagulopathy’. More recently, however, compelling evidences have been provided on the occurrence of thrombotic events in the portal and systemic circulation.3–5 Portal vein thrombosis (PVT) is predominantly observed in patients with moderate to severe liver failure with a variable prevalence ranging from 0.6 to 25%. Only fewstudies have provided a longitudinal assessment of the PVT incidence and its sequelae, including recurrence and survival.9–14 Due to the variability of PVT incidence and the paucity of data regarding recurrence and survival,15–20 we prospectively analysed the incidence and the recurrence of PVT in the population of Portal vein thrombosis Relevance On Liver cirrhosis: ItalianVenous thromboticEventsRegistry (PROLIVER), a multi-centre study,8 which involved 43 enrolling centres in Italy (ClinicalTrials.gov Identifier: NCT01470547).

Published
2019

24. Frequency of Left Ventricular Hypertrophy in Non-Valvular Atrial Fibrillation

Author

Proietti M, Marra AM, Tassone EJ, De Vuono S, Corrao S, Gobbi P, Perticone F, Corazza GR, Basili S, Lip GY, Violi F, Raparelli V, ARAPACIS Study Investigators, GIS Group, Alessandri Cesare, Serviddio Gaetano, Fascetti Stefano, Serra Pietro, Palange Paolo, Greco Eleonora, Bruno Graziella, Averna Maurizio, Giammanco Antonina, Sposito Pietro, De Cristofaro Raimondo, De Gennaro Leonardo, Loria Paola, Pellegrini Elisa, Cominacini Luciano, Mozzini Chiara, Sprovieri Mario, Spagnuolo Vitaliano, Cerqua Giannantonio, Cerasola Giovanni, Mulé Giuseppe, Barbagallo Mario, Lo Sciuto Salvatore, Monteverde Alfredo, Saitta Antonino, Lo Gullo Alberto, Malatino Lorenzo, Cilia Chiara, Licata Giuseppe, Tuttolomondo Antonino, Conigliaro Roberta, Pinto Antonio, Di Raimondo Domenico, Signorelli Santo, Anzaldi Massimiliano, De Palma Daniela, Galderisi Maurizio, Cudemo Giuseppe, Galletti Ferruccio, Fazio Valeria, De Luca Nicola, Meccariello Alfonso, Caputo Dario, De Donato Maria Teresa, Iannuzi Arcangelo, Bresciani Alessandro, Giunta Riccardo, Cimini Claudia, Durante Mangoni Emanuele, Agrusta Federica, Iorio Federica, Adinolfi Luigi E, Sellitto Ausilia, Restivo Luciano, Bellis Paolo, Tirelli Paolo, Sacerdoti David, Pesce Paola, Vanni Dino, Iuliano Luigi, Ciacciarelli Marco, Pacelli Antonio, Palazzuoli Alberto, Cacciafesta Mauro, Gueli Nicola, Capeci William, Tarquinio Nicola, Pellegrini Francesco, Vincentelli Giovanni Maria, Ravallese Ferdinando, Santini Claudio, Letizia Claudio, Petramala Luigi, Zinnamosca Laura, Cilli Mirella, Savoriti Claudio, Falaschi Paolo, Martocchia Antonio, Stefanelli Manuela, Marigliano Vincenzo, Lo Iacono Cristina, Brusco Simona, Bertazzoni Giuliano, Attalla El Halabieh Elias, Paradiso Michele, Lizzi Eugenio Maria, Timmi Stefano, Battisti Paola, Cerci Sabina, Ciavolella Massimo, Di Veroli Claudio, Malci Francesco, De Ciocchis Anita, Abate Damiano, Castellino Pietro, Curto Irene, Vecchio Claudia, Mannarino Elmo, Pasqualini Leonella, Fattori Chiara, Pende Aldo, Denegri Andrea, Artom Nathan, Ricchio Roberto, Fimognari Filippo Luca, Alletto Maurizio, Messina Simona, Sesti Giorgio, Arturi Franco, Grembiale Alessandro, Perticone Francesco, Maio Raffaele, Scarpino Paola Elisa, Carullo Giuseppe, Sciacqua Angela, Frugiuele Pierluigi, Battaglia Giuseppe, Vidili Gianpaolo, Atzori Sebastiana, Delitala Giuseppe, Davì Giovanni, Angelucci Ermanno, Sestili Simona, Traisci Giancarlo, De Feudis Lucrezia, Di Michele Dario, Fava Alessandra, Balsano Clara, De Ciantis Pierpaolo, Desideri Giovambattista, Camerota Antonio, Migliacci Rino, Porciello Giovanni, Mezzetti Matteo, Gresele Paolo, Vedovati Cristina, Fierro Tiziana, Puccetti Luca, Scarpini Francesca, Bertolotti Marco, Mussi Chiara, Boddi Maria, Savino Andrea, Contri Silvia, Saller Alois, Fabris Fabrizio, Pesavento Raffaele, Filippi Lucia, Vedovetto Valentina, Puato Massimo, Treleani Martina, De Luca Elisabetta, De Zaiacomo Francesca, Giantin Valter, Semplicini Andrea, Minuz Pietro, Calabria Stefano, Romano Simone, Fantin Francesco, Manica Angela, Stockner Ingrid, Pattis Peter, Gutmann Bernhard, Catena Cristiana, Colussi GianLuca, Annoni Giorgio, Bruni Adriana Antonella, Castagna Alberto, Spinelli Diana, Corazza Gino Roberto, Miceli Emanuela, Padula, Schinco Giuseppina, Spreafico Sibilla, Secchi Beatrice, Vanoli Massimo, Casella Gianluca, Serra Maria Grazia, Longo Stefania, Antonaci Salvatore, Belfiore Anna, Ricci Lara, Ventrella Francesco, Iamele Luigi, Bianco Cesare, Santovito Donato, Cipollone Francesco, Nicolai Salvatore, Salvati Filippo, Rini Giovan Battista, Scozzari Francesca, Muiesan Maria Lorenza, Salvetti Massimo, Bazza Abramo, Picardi Antonio, De Vincentis Antonio, Cosio Paolo, Terzolo Massimo, Madaffari Bruno, Parasporo Bruno, Fenoglio Luigi, Bracco Christian, Melchio Remo, Gentili Tamira, Salvi Aldo, Nitti Cinzia, Falsetti L, Gabrielli Armando, Paglione Ivano, Capucci Alessandro, Brambatti Michela, Sparagna Armando, Tirotta Daniela, Andreozzi Paola, Ettorre Evaristo, Viscogliosi Giovanni, Rossi Fanelli Fillippo, Delfino Massimo, Glorioso Nicola, Melis Giada, Marras Gianfranca, Matta Michela, Sacco Andrea, Stellitano Elio, Scordo Anna, Russo Franco, Caruso Assunta Antonietta, Porreca Ettore, Santilli Francesca, Tana Marco, Ferri Claudio, Grassi Davide, Cheli Paola, Portincasa Piero, Muscianisi Giuseppe, Giordani Sara, Stanghellini Vincenzo, Sabbà Carlo, Suppressa Patrizia, Mancuso Gerardo, Bartone Mosè, Calipari Daniela, Arcidiacono Giuseppe, Bellanuova Ignazio, Ferraro Maria, Scalzo Antonio, Marigliano Giampietro, Cozzolino Domenico, Lampitella Antonio, Acri Vera, Galasso Domenico, Mazzei Francesca, Galasso Salvatore, Buratti Alberto, Porta Massimo, Brizzi Maria Felice, Fattorini Annalisa, Sampietro Francesca, D’Angelo Armando, Pala Marco, Fabbian Fabio, Manfredini Roberto, Moroni Carlo, Valente Lucia, Lopreiato Francesco, Parente Fernando, Moia Marco, Braham Simon, Rossi Marco, Pesce Margherita, Gentile Adelina, Catozzo Vania, Di Napoli Mariarosaria, Baciarello Giacinto, Rancan Elena, Ageno Walter, Guasti Luigina, Ciccaglioni Antonio, Negri Silvia, Polselli Marco, Abbate Rosanna, Marcucci Rossella, Cangemi Roberto, Pignataro Francesca Serena, Marco Proietti, Pastori Daniele, Ferro Domenico, Loffredo Lorenzo, Perri Ludovica, Catasca Elisa, Raparelli Valeria, Napoleone Laura, Talerico Giovanni, Calvieri Camilla, Vicario Tommasa, Russo Roberta, Saliola Mirella, Del Ben Maria, Angelico Francesco, Bucci Tommaso, Baratta Francesco, DATA AND SAFETY MONITORING BOARD (DSMB): Vestri Anna Rita, Farcomeni Alessio, Di Tanna Gianluca, STUDY COORDINATORS: Basili Stefania, Davi’ Giovanni, STEERING COMMITTEE OF ARAPACIS STUDY: Violi Francesco, Lip Gregory YH, Hiatt William R, Vestri Anna Rita, Mannucci Pier Mannuccio, Proietti Marco, Bazzini Cristina, Bianchi Paola Ilaria, Boari Benedetta, Buonauro Agostino, Buttà Carmelo, Buzzetti Elena, Carleo Pietro, Carrabba Maria Domenica, Castorani Luigi, Cecchetto Lara, Colombo Barbara Maria, De Giorgi Alfredo, De Vuono Stefano, Del Corso Lisette, Di Giosia Paolo, Falsetti Lorenzo, Forgione Alessandra, Hijazi Daniel, Lorusso Giusi, Marra Alberto Maria, Masala Maristella, Montebianco Abenavoli Ludovico, Murgia Giuseppe, Naccarato Paola, Pattoneri Paolo, Perego Francesca, Pinto Daniela, Pinna Miriam Pretti Vincenzo, Pucci Giacomo, Salinaro Francesco, Sirico Domenico, Tassone Eliezer Joseph, Torres Daniele, Vazzana Natale, Vecchio Claudia Rita, Vitale Francesco, Proietti M, Marra AM, Tassone EJ, De Vuono S, Corrao S, Gobbi P, Perticone F, Corazza GR, Basili S, Lip GY, Violi F, Raparelli V, ARAPACIS Study Investigators, GIS Group, Alessandri Cesare, Serviddio Gaetano, Fascetti Stefano, Serra Pietro, Palange Paolo, Greco Eleonora, Bruno Graziella, Averna Maurizio, Giammanco Antonina, Sposito Pietro, De Cristofaro Raimondo, De Gennaro Leonardo, Loria Paola, Pellegrini Elisa, Cominacini Luciano, Mozzini Chiara, Sprovieri Mario, Spagnuolo Vitaliano, Cerqua Giannantonio, Cerasola Giovanni, Mulé Giuseppe, Barbagallo Mario, Lo Sciuto Salvatore, Monteverde Alfredo, Saitta Antonino, Lo Gullo Alberto, Malatino Lorenzo, Cilia Chiara, Licata Giuseppe, Tuttolomondo Antonino, Conigliaro Roberta, Pinto Antonio, Di Raimondo Domenico, Signorelli Santo, Anzaldi Massimiliano, De Palma Daniela, Galderisi Maurizio, Cudemo Giuseppe, Galletti Ferruccio, Fazio Valeria, De Luca Nicola, Meccariello Alfonso, Caputo Dario, De Donato Maria Teresa, Iannuzi Arcangelo, Bresciani Alessandro, Giunta Riccardo, Cimini Claudia, Durante Mangoni Emanuele, Agrusta Federica, Iorio Federica, Adinolfi Luigi E, Sellitto Ausilia, Restivo Luciano, Bellis Paolo, Tirelli Paolo, Sacerdoti David, Pesce Paola, Vanni Dino, Iuliano Luigi, Ciacciarelli Marco, Pacelli Antonio, Palazzuoli Alberto, Cacciafesta Mauro, Gueli Nicola, Capeci William, Tarquinio Nicola, Pellegrini Francesco, Vincentelli Giovanni Maria, Ravallese Ferdinando, Santini Claudio, Letizia Claudio, Petramala Luigi, Zinnamosca Laura, Cilli Mirella, Savoriti Claudio, Falaschi Paolo, Martocchia Antonio, Stefanelli Manuela, Marigliano Vincenzo, Lo Iacono Cristina, Brusco Simona, Bertazzoni Giuliano, Attalla El Halabieh Elias, Paradiso Michele, Lizzi Eugenio Maria, Timmi Stefano, Battisti Paola, Cerci Sabina, Ciavolella Massimo, Di Veroli Claudio, Malci Francesco, De Ciocchis Anita, Abate Damiano, Castellino Pietro, Curto Irene, Vecchio Claudia, Mannarino Elmo, Pasqualini Leonella, Fattori Chiara, Pende Aldo, Denegri Andrea, Artom Nathan, Ricchio Roberto, Fimognari Filippo Luca, Alletto Maurizio, Messina Simona, Sesti Giorgio, Arturi Franco, Grembiale Alessandro, Perticone Francesco, Maio Raffaele, Scarpino Paola Elisa, Carullo Giuseppe, Sciacqua Angela, Frugiuele Pierluigi, Spagnuolo Vitaliano, Battaglia Giuseppe, Vidili Gianpaolo, Atzori Sebastiana, Delitala Giuseppe, Davì Giovanni, Angelucci Ermanno, Sestili Simona, Traisci Giancarlo, De Feudis Lucrezia, Di Michele Dario, Fava Alessandra, Balsano Clara, De Ciantis Pierpaolo, Desideri Giovambattista, Camerota Antonio, Migliacci Rino, Porciello Giovanni, Mezzetti Matteo, Gresele Paolo, Vedovati Cristina, Fierro Tiziana, Puccetti Luca, Scarpini Francesca, Bertolotti Marco, Mussi Chiara, Boddi Maria, Savino Andrea, Contri Silvia, Saller Alois, Fabris Fabrizio, Pesavento Raffaele, Filippi Lucia, Vedovetto Valentina, Puato Massimo, Fabris Fabrizio, Treleani Martina, De Luca Elisabetta, De Zaiacomo Francesca, Giantin Valter, Semplicini Andrea, Minuz Pietro, Calabria Stefano, Romano Simone, Fantin Francesco, Manica Angela, Stockner Ingrid, Pattis Peter, Gutmann Bernhard, Catena Cristiana, Colussi GianLuca, Annoni Giorgio, Bruni Adriana Antonella, Castagna Alberto, Spinelli Diana, Corazza Gino Roberto, Miceli Emanuela, Padula, Schinco Giuseppina, Spreafico Sibilla, Secchi Beatrice, Vanoli Massimo, Casella Gianluca, Serra Maria Grazia, Longo Stefania, Antonaci Salvatore, Belfiore Anna, Ricci Lara, Ventrella Francesco, Iamele Luigi, Bianco Cesare, Santovito Donato, Cipollone Francesco, Nicolai Salvatore, Salvati Filippo, Rini Giovan Battista, Scozzari Francesca, Muiesan Maria Lorenza, Salvetti Massimo, Bazza Abramo, Picardi Antonio, De Vincentis Antonio, Cosio Paolo, Terzolo Massimo, Madaffari Bruno, Parasporo Bruno, Fenoglio Luigi, Bracco Christian, Melchio Remo, Gentili Tamira, Salvi Aldo, Nitti Cinzia, Falsetti L, Gabrielli Armando, Paglione Ivano, Capucci Alessandro, Brambatti Michela, Sparagna Armando, Tirotta Daniela, Andreozzi Paola, Ettorre Evaristo, Viscogliosi Giovanni, Rossi Fanelli Fillippo, Delfino Massimo, Glorioso Nicola, Melis Giada, Marras Gianfranca, Matta Michela, Sacco Andrea, Stellitano Elio, Scordo Anna, Russo Franco, Caruso Assunta Antonietta, Porreca Ettore, Santilli Francesca, Tana Marco, Ferri Claudio, Grassi Davide, Cheli Paola, Portincasa Piero, Muscianisi Giuseppe, Giordani Sara, Stanghellini Vincenzo, Sabbà Carlo, Suppressa Patrizia, Mancuso Gerardo, Bartone Mosè, Calipari Daniela, Arcidiacono Giuseppe, Bellanuova Ignazio, Ferraro Maria, Scalzo Antonio, Marigliano Giampietro, Cozzolino Domenico, Lampitella Antonio, Acri Vera, Galasso Domenico, Mazzei Francesca, Galasso Salvatore, Buratti Alberto, Porta Massimo, Brizzi Maria Felice, Fattorini Annalisa, Sampietro Francesca, D’Angelo Armando, Pala Marco, Fabbian Fabio, Manfredini Roberto, Moroni Carlo, Valente Lucia, Lopreiato Francesco, Parente Fernando, Moia Marco, Braham Simon, Rossi Marco, Pesce Margherita, Gentile Adelina, Catozzo Vania, Di Napoli Mariarosaria, Baciarello Giacinto, Rancan Elena, Ageno Walter, Guasti Luigina, Ciccaglioni Antonio, Negri Silvia, Polselli Marco, Abbate Rosanna, Marcucci Rossella, Cangemi Roberto, Pignataro Francesca Serena, Marco Proietti, Pastori Daniele, Ferro Domenico, Loffredo Lorenzo, Perri Ludovica, Catasca Elisa, Raparelli Valeria, Napoleone Laura, Talerico Giovanni, Calvieri Camilla, Vicario Tommasa, Russo Roberta, Saliola Mirella, Del Ben Maria, Angelico Francesco, Bucci Tommaso, Baratta Francesco, DATA AND SAFETY MONITORING BOARD (DSMB): Vestri Anna Rita, Farcomeni Alessio, Di Tanna Gianluca, STUDY COORDINATORS: Basili Stefania, Davi’ Giovanni, STEERING COMMITTEE OF ARAPACIS STUDY: Violi Francesco, Perticone Francesco, Lip Gregory YH, Hiatt William R, Vestri Anna Rita, Corazza Gino Roberto, Mannucci Pier Mannuccio, Licata Giuseppe, Moroni Carlo, Proietti Marco, Anzaldi Massimiliano, Bazzini Cristina, Bianchi Paola Ilaria, Boari Benedetta, Bracco Christian, Buonauro Agostino, Buttà Carmelo, Buzzetti Elena, Calabria Stefano, Capeci William, Carleo Pietro, Carrabba Maria Domenica, Castorani Luigi, Cecchetto Lara, Cimini Claudia, Colombo Barbara Maria, De Giorgi Alfredo, De Vuono Stefano, Denegri Andrea, Del Corso Lisette, Di Giosia Paolo, Durante Mangoni Emanuele, Falsetti Lorenzo, Forgione Alessandra, Grassi Davide, Grembiale Alessandro, Hijazi Daniel, Iamele Luigi, Lorusso Giusi, Marra Alberto Maria, Masala Maristella, Montebianco Abenavoli Ludovico, Murgia Giuseppe, Naccarato Paola, Pattoneri Paolo, Perego Francesca, Pesce Paola, Petramala Luigi, Pinto Daniela, Pinna Miriam Pretti Vincenzo, Pucci Giacomo, Raparelli Valeria, Salinaro Francesco, Santilli Francesca, Scarpini Francesca, Sirico Domenico, Suppressa Patrizia, Tassone Eliezer Joseph, Torres Daniele, Vazzana Natale, Vecchio Claudia Rita, Vidili Gianpaolo, Vitale Francesco, Proietti, M., Marra, A., Tassone, E., De Vuono, S., Corrao, S., Gobbi, P., Perticone, F., Corazza, G., Basili, S., Lip, G., Violi, F., Raparelli, V., Marra, A. M., Tassone, E. J., Corazza, G. R., and Lip, G. Y. H.

Subjects
Registrie, Male, Cross-sectional study, Myocardial Infarction, Longitudinal Studie, Left ventricular hypertrophy, Cohort Studies, non-valvular atrial fibrillation, Atrial Fibrillation, 80 and over, Prevalence, echocardiography, Myocardial infarction, Longitudinal Studies, Prospective Studies, Registries, Prospective cohort study, Ultrasonography, Aged, 80 and over, education.field_of_study, Medicine (all), Atrial fibrillation, Diabetes Mellitu, Middle Aged, Left Ventricular, left ventricular hypertrophy, Italy, Hypertension, Cardiology, Age Distribution, Aged, Ankle Brachial Index, Cross-Sectional Studies, Diabetes Mellitus, Female, Humans, Hypertrophy, Left Ventricular, Logistic Models, Peripheral Arterial Disease, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, Logistic Model, Population, Concentric hypertrophy, Socio-culturale, non-valvular atrial fibrillation, left ventricular hypertrophy, echocardiography, cardiovascular diseases, Internal medicine, medicine, cardiovascular diseases, education, Cross-Sectional Studie, business.industry, Odds ratio, Hypertrophy, medicine.disease, Prospective Studie, Cohort Studie, business
Abstract

Left ventricular hypertrophy (LVH) is significantly related to adverse clinical outcomes in patients at high risk of cardiovascular events. In patients with atrial fibrillation (AF), data on LVH, that is, prevalence and determinants, are inconsistent mainly because of different definitions and heterogeneity of study populations. We determined echocardiographic-based LVH prevalence and clinical factors independently associated with its development in a prospective cohort of patients with non-valvular (NV) AF. From the "Atrial Fibrillation Registry for Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study" (ARAPACIS) population, 1,184 patients with NVAF (mean age 72 ± 11 years; 56% men) with complete data to define LVH were selected. ARAPACIS is a multicenter, observational, prospective, longitudinal on-going study designed to estimate prevalence of peripheral artery disease in patients with NVAF. We found a high prevalence of LVH (52%) in patients with NVAF. Compared to those without LVH, patients with AF with LVH were older and had a higher prevalence of hypertension, diabetes, and previous myocardial infarction (MI). A higher prevalence of ankle-brachial index ≤0.90 was seen in patients with LVH (22 vs 17%, p = 0.0392). Patients with LVH were at significantly higher thromboembolic risk, with CHA2DS2-VASc ≥2 seen in 93% of LVH and in 73% of patients without LVH (p

Published
2015

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