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1. Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.

Author

Wang, Yu-Chen, Wang, Xi, Yu, Jiaji, Ma, Feiyang, Li, Zhe, Zhou, Yang, Zeng, Samuel, Ma, Xiaoya, Li, Yan-Ruide, Neal, Adam, Huang, Jie, To, Angela, Clarke, Nicole, Memarzadeh, Sanaz, Pellegrini, Matteo, and Yang, Lili

Subjects
T-Lymphocytes, Cell Line, Tumor, Animals, Mice, Inbred C57BL, Humans, Mice, Neoplasms, Lymphoma, Melanoma, Breast Neoplasms, Ovarian Neoplasms, Reactive Oxygen Species, Monoamine Oxidase, Monoamine Oxidase Inhibitors, Immunotherapy, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Drug Synergism, Female, Kaplan-Meier Estimate, Single-Cell Analysis, Programmed Cell Death 1 Receptor, RNA-Seq, Tumor-Associated Macrophages, Brain Disorders, Vaccine Related, Neurosciences, Cancer, 5.1 Pharmaceuticals
Abstract

Targeting tumor-associated macrophages (TAMs) is a promising strategy to modify the immunosuppressive tumor microenvironment and improve cancer immunotherapy. Monoamine oxidase A (MAO-A) is an enzyme best known for its function in the brain; small molecule MAO inhibitors (MAOIs) are clinically used for treating neurological disorders. Here we observe MAO-A induction in mouse and human TAMs. MAO-A-deficient mice exhibit decreased TAM immunosuppressive functions corresponding with enhanced antitumor immunity. MAOI treatment induces TAM reprogramming and suppresses tumor growth in preclinical mouse syngeneic and human xenograft tumor models. Combining MAOI and anti-PD-1 treatments results in synergistic tumor suppression. Clinical data correlation studies associate high intratumoral MAOA expression with poor patient survival in a broad range of cancers. We further demonstrate that MAO-A promotes TAM immunosuppressive polarization via upregulating oxidative stress. Together, these data identify MAO-A as a critical regulator of TAMs and support repurposing MAOIs for TAM reprogramming to improve cancer immunotherapy.

Published
2021

2. Creatine uptake regulates CD8 T cell antitumor immunity

Author

Di Biase, Stefano, Ma, Xiaoya, Wang, Xi, Yu, Jiaji, Wang, Yu-Chen, Smith, Drake J, Zhou, Yang, Li, Zhe, Kim, Yu Jeong, Clarke, Nicole, To, Angela, and Yang, Lili

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Nutrition, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Animals, Antigens, Neoplasm, CD8-Positive T-Lymphocytes, Cell Line, Tumor, Creatine, Dietary Supplements, Energy Metabolism, Gene Expression Regulation, Neoplastic, Humans, Immunomodulation, Lymphocyte Activation, Membrane Transport Proteins, Mice, Mice, Knockout, Models, Biological, Neoplasms, Tumor Microenvironment, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

T cells demand massive energy to combat cancer; however, the metabolic regulators controlling antitumor T cell immunity have just begun to be unveiled. When studying nutrient usage of tumor-infiltrating immune cells in mice, we detected a sharp increase of the expression of a CrT (Slc6a8) gene, which encodes a surface transporter controlling the uptake of creatine into a cell. Using CrT knockout mice, we showed that creatine uptake deficiency severely impaired antitumor T cell immunity. Supplementing creatine to WT mice significantly suppressed tumor growth in multiple mouse tumor models, and the combination of creatine supplementation with a PD-1/PD-L1 blockade treatment showed synergistic tumor suppression efficacy. We further demonstrated that creatine acts as a "molecular battery" conserving bioenergy to power T cell activities. Therefore, our results have identified creatine as an important metabolic regulator controlling antitumor T cell immunity, underscoring the potential of creatine supplementation to improve T cell-based cancer immunotherapies.

Published
2019

7. Asthma control in severe asthma patients treated with tezepelumab: A prospective, observational, real-world evidence study in Europe and Canada (ASCENT)

Author

Milger-Kneidinger,, Katrin, primary, Dorscheid, Del, additional, Gessner, Christian, additional, Sundbom, Fredrik, additional, Stolz, Daiana, additional, Urbanski, Hannah, additional, Le, Tham, additional, Emmanuel, Benjamin, additional, Tran, Trung, additional, Clarke, Deborah, additional, Llanos, Jean-Pierre, additional, Clarke, Nicole, additional, Ruckh, Tim, additional, Kayaniyil, Sheena, additional, Martin, Neil, additional, Stjepanovic, Neda, additional, and Porsbjerg, Celeste, additional

Published
2023
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8. Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, Sayles, Leanne C, Vaka, Dedeepya, Khatri, Purvesh, Gevaert, Olivier, Chen, Ron, Zheng, Yanyan, Gillespie, Anna K, Clarke, Nicole, Xu, Yue, Shrager, Joseph, Hoang, Chuong D, Plevritis, Sylvia, Butte, Atul J, and Sweet-Cordero, E Alejandro

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Immunology, Oncology and Carcinogenesis, Genetics, Cancer, Lung, Lung Cancer, Aetiology, 2.1 Biological and endogenous factors, Adenocarcinoma, Animals, Carcinoma, Non-Small-Cell Lung, Cell Growth Processes, Cell Line, Tumor, Fibroblasts, Humans, Interleukin-6, Lung Neoplasms, Mice, Species Specificity, Stromal Cells, Transplantation, Heterologous, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Cancer-associated fibroblasts (CAF) have been reported to support tumor progression by a variety of mechanisms. However, their role in the progression of non-small cell lung cancer (NSCLC) remains poorly defined. In addition, the extent to which specific proteins secreted by CAFs contribute directly to tumor growth is unclear. To study the role of CAFs in NSCLCs, a cross-species functional characterization of mouse and human lung CAFs was conducted. CAFs supported the growth of lung cancer cells in vivo by secretion of soluble factors that directly stimulate the growth of tumor cells. Gene expression analysis comparing normal mouse lung fibroblasts and mouse lung CAFs identified multiple genes that correlate with the CAF phenotype. A gene signature of secreted genes upregulated in CAFs was an independent marker of poor survival in patients with NSCLC. This secreted gene signature was upregulated in normal lung fibroblasts after long-term exposure to tumor cells, showing that lung fibroblasts are "educated" by tumor cells to acquire a CAF-like phenotype. Functional studies identified important roles for CLCF1-CNTFR and interleukin (IL)-6-IL-6R signaling in promoting growth of NSCLCs. This study identifies novel soluble factors contributing to the CAF protumorigenic phenotype in NSCLCs and suggests new avenues for the development of therapeutic strategies.

Published
2012

10. Data from An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression

Author

Indeglia, Alexandra, primary, Leung, Jessica C., primary, Miller, Sven A., primary, Leu, Julia I-Ju, primary, Dougherty, James F., primary, Clarke, Nicole L., primary, Kirven, Nicole A., primary, Shao, Chunlei, primary, Ke, Lei, primary, Lovell, Scott, primary, Barnoud, Thibaut, primary, Lu, David Y., primary, Lin, Cindy, primary, Kannan, Toshitha, primary, Battaile, Kevin P., primary, Yang, Tyler Hong Loong, primary, Batista Oliva, Isabela, primary, Claiborne, Daniel T., primary, Vogel, Peter, primary, Liu, Lijun, primary, Liu, Qin, primary, Nefedova, Yulia, primary, Cassel, Joel, primary, Auslander, Noam, primary, Kossenkov, Andrew V., primary, Karanicolas, John, primary, and Murphy, Maureen E., primary

Published
2023
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11. Table S3 from An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression

Author

Indeglia, Alexandra, primary, Leung, Jessica C., primary, Miller, Sven A., primary, Leu, Julia I-Ju, primary, Dougherty, James F., primary, Clarke, Nicole L., primary, Kirven, Nicole A., primary, Shao, Chunlei, primary, Ke, Lei, primary, Lovell, Scott, primary, Barnoud, Thibaut, primary, Lu, David Y., primary, Lin, Cindy, primary, Kannan, Toshitha, primary, Battaile, Kevin P., primary, Yang, Tyler Hong Loong, primary, Batista Oliva, Isabela, primary, Claiborne, Daniel T., primary, Vogel, Peter, primary, Liu, Lijun, primary, Liu, Qin, primary, Nefedova, Yulia, primary, Cassel, Joel, primary, Auslander, Noam, primary, Kossenkov, Andrew V., primary, Karanicolas, John, primary, and Murphy, Maureen E., primary

Published
2023
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12. Supplementary Figures S1-S8 from An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression

Author

Indeglia, Alexandra, primary, Leung, Jessica C., primary, Miller, Sven A., primary, Leu, Julia I-Ju, primary, Dougherty, James F., primary, Clarke, Nicole L., primary, Kirven, Nicole A., primary, Shao, Chunlei, primary, Ke, Lei, primary, Lovell, Scott, primary, Barnoud, Thibaut, primary, Lu, David Y., primary, Lin, Cindy, primary, Kannan, Toshitha, primary, Battaile, Kevin P., primary, Yang, Tyler Hong Loong, primary, Batista Oliva, Isabela, primary, Claiborne, Daniel T., primary, Vogel, Peter, primary, Liu, Lijun, primary, Liu, Qin, primary, Nefedova, Yulia, primary, Cassel, Joel, primary, Auslander, Noam, primary, Kossenkov, Andrew V., primary, Karanicolas, John, primary, and Murphy, Maureen E., primary

Published
2023
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13. Implementing buprenorphine prolonged-release injection using a health at the margins approach for transactional sex-workers

Author

Gittins, Rosalind, Tay Wee Teck, Joseph, Knowles, Rebecca, Clarke, Nicole, Baldacchino, Alexander Mario, University of St Andrews. Population and Behavioural Science Division, University of St Andrews. School of Medicine, and University of St Andrews. Centre for Minorities Research (CMR)

Subjects
MCC, Outreach, SDG 3 - Good Health and Well-being, RA0421, RA0421 Public health. Hygiene. Preventive Medicine, Trauma-informed, Micro-induction, Sex-work, Buprenorphine
Abstract

Funding: Humankind Charity. Background Access to prescribed interventions and retention in treatment services are associated with improved health outcomes and reduced premature mortality rates for people living with opioid use disorder (OUD). In Leeds, transactional sex-workers frequently cycled in and out of treatment for OUD such that they never reached a level of engagement that permitted opportunities to meet their healthcare or housing needs. Barriers to accessing care provision include an itinerant lifestyle, difficulties with travel at unpredictable hours, impacting upon adherence to medication regimens including daily supervised consumption. Objectives To use a co-produced, ‘health at the margins’ approach, to reach the sex-working population in Leeds, and support informed choices about the potential to receive buprenorphine prolonged release injection (BPRI) as a treatment option for OUD.Methods BPRI was introduced using a theory of change model and improvements in sex-worker care delivery was reviewed. Strategies included buprenorphine micro-induction, shared decision-making, collaborative multi-agency working and supporting a strengths-based and trauma-informed approach. Results Benefits of BPRI included removal of the need for daily pharmacy visits, reducing the risk of diversion, improved medication adherence, stability and engagement with treatment and supportive services. Conclusions BPRI may offer an additional option for pharmacological interventions for people with OUD where there may be increased barriers to accessing treatment for example due to sex-working. Strategies for effective BPRI include micro-induction, shared decision-making, collaborative multi-agency working and supporting a strengths-based approach. Publisher PDF

Published
2023

14. An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression

Author

Indeglia, Alexandra, primary, Leung, Jessica C., additional, Miller, Sven A., additional, Leu, Julia I-Ju, additional, Dougherty, James F., additional, Clarke, Nicole L., additional, Kirven, Nicole A., additional, Shao, Chunlei, additional, Ke, Lei, additional, Lovell, Scott, additional, Barnoud, Thibaut, additional, Lu, David Y., additional, Lin, Cindy, additional, Kannan, Toshitha, additional, Battaile, Kevin P., additional, Yang, Tyler Hong Loong, additional, Batista Oliva, Isabela, additional, Claiborne, Daniel T., additional, Vogel, Peter, additional, Liu, Lijun, additional, Liu, Qin, additional, Nefedova, Yulia, additional, Cassel, Joel, additional, Auslander, Noam, additional, Kossenkov, Andrew V., additional, Karanicolas, John, additional, and Murphy, Maureen E., additional

Published
2023
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15. Data from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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16. Supplementary Methods from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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17. Supplementary Figure 1 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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18. Supplementary Table 2 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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19. Supplementary Table 4 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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20. Supplementary Figure 5 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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21. Supplementary Table 1 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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22. Supplementary Table 3 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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23. Supplementary Figure 4 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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24. Supplementary Figure 3 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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25. Supplementary Table 6 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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26. Supplementary Figure Legends 1-6, Table Legends 1-6 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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27. Supplementary Figure 6 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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28. Supplementary Table 5 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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29. Supplementary Figure 2 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo

Author

Vicent, Silvestre, primary, Sayles, Leanne C., primary, Vaka, Dedeepya, primary, Khatri, Purvesh, primary, Gevaert, Olivier, primary, Chen, Ron, primary, Zheng, Yanyan, primary, Gillespie, Anna K., primary, Clarke, Nicole, primary, Xu, Yue, primary, Shrager, Joseph, primary, Hoang, Chuong D., primary, Plevritis, Sylvia, primary, Butte, Atul J., primary, and Sweet-Cordero, E. Alejandro, primary

Published
2023
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30. Common activities and predictive gene signature identified for genetic hypomorphs of TP53

Author

Leung, Jessica C., primary, Leu, Julia I-Ju, additional, Indeglia, Alexandra, additional, Kannan, Toshitha, additional, Clarke, Nicole L., additional, Kirven, Nicole A., additional, Dweep, Harsh, additional, Garlick, David, additional, Barnoud, Thibaut, additional, Kossenkov, Andrew V., additional, George, Donna L., additional, and Murphy, Maureen E., additional

Published
2023
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33. PASSAGE: A PHASE 4, SINGLE-ARM, OPEN-LABEL STUDY TO EVALUATE THE EFFECTIVENESS AND SAFETY OF TEZEPELUMAB IN PATIENTS WITH SEVERE ASTHMA, INCLUDING UNDER-REPRESENTED GROUPS

Author

LUGOGO, NJIRA L, primary, AKUTHOTA, PRAVEEN, additional, K MATHUR, SAMEER, additional, BURNETTE, AUTUMN, additional, SUMINO, KAHARU, additional, ARYA, NIKITA, additional, CLARKE, NICOLE, additional, W LINDSLEY, ANDREW, additional, LLANOS ACKERT, JEAN-PIERRE, additional, AMBROSE, CHRISTOPHER, additional, COOK, WILLIAM, additional, and EMMANUEL, BENJAMIN, additional

Published
2022
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36. The genetics of tumor suppression by p53

Author

Murphy, Maureen, primary, Leung, Jessica, additional, Leu, Julia, additional, Indeglia, Alexandra, additional, Clarke, Nicole, additional, Kannan, Toshitha, additional, Kirven, Nicole, additional, Barnoud, Thibaut, additional, Kossenkov, Andrew, additional, and George, Donna L., additional

Published
2022
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39. A multicase study on African American male students : the least identified and represented in the gifted and talented education program at the upper elementary level

Author

Clarke, Nicole Angella and Clarke, Nicole Angella

Subjects
African American school children Case studies. United States, Elementary school teachers Case studies. United States, Gifted children Education (Elementary), Élèves du primaire noirs américains Études de cas. États-Unis, Enfants surdoués Enseignement primaire., African American school children, Elementary school teachers, Gifted children Education (Elementary), United States
Abstract

The purpose of this multicase study was to develop an understanding of educators' perspectives of African American male students being the least identified and represented in the gifted and talented program at two elementary schools. The theories that guided this study were the expectancy-value theory and the social cognitive theory. Given the purpose of this study, the following central research question framed this study: What are educators' perspectives on African American male students being the least identified and represented in the gifted and talented program at the elementary level? The participants who took part in this study were 10 teachers who have taught or were currently teaching fourth or fifth grade. The three data collection methods included interviews, focus groups, and educators' letters to other educators sharing their approach to how they motivated and inspired African American male students to rise above stereotype and perform to their ability. The data were analyzed using cross-case analysis methodology; the analysis employed member checking, peer review, triangulation, and an audit trail to ensure trustworthy findings. Four major themes emerged: systemic issues, hindrances, commitments and responsibilities, and self-efficacy. It is perceived that African American male students lack representation in gifted and talented programs because some educators refuse to acknowledge their own biases and negative attitudes toward African American male students. The identification process is heavily flawed, relying on standardized assessments, and favors students with a middle-class background. The study concluded with recommendations to school divisions, policymakers, and educators.

Published
2021

40. Targeting monoamine oxidase A for T cell–based cancer immunotherapy

Author

Wang, Xi, primary, Li, Bo, additional, Kim, Yu Jeong, additional, Wang, Yu-Chen, additional, Li, Zhe, additional, Yu, Jiaji, additional, Zeng, Samuel, additional, Ma, Xiaoya, additional, Choi, In Young, additional, Di Biase, Stefano, additional, Smith, Drake J., additional, Zhou, Yang, additional, Li, Yan-Ruide, additional, Ma, Feiyang, additional, Huang, Jie, additional, Clarke, Nicole, additional, To, Angela, additional, Gong, Laura, additional, Pham, Alexander T., additional, Moon, Heesung, additional, Pellegrini, Matteo, additional, and Yang, Lili, additional

Published
2021
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41. Safety, pharmacokinetics, efficacy, and preliminary biomarker data of first-in-class BI 765063, a selective SIRPα inhibitor: Results of monotherapy dose escalation in phase 1 study in patients with advanced solid tumors.

Author

Champiat, Stéphane, primary, Cassier, Philippe A., additional, Kotecki, Nuria, additional, Korakis, Iphigenie, additional, Vinceneux, Armelle, additional, Jungels, Christiane, additional, Blatchford, Jon, additional, Elgadi, Mabrouk M., additional, Clarke, Nicole, additional, Fromond, Claudia, additional, Poirier, Nicolas, additional, Vasseur, Berangere, additional, Marabelle, Aurelien, additional, and Delord, Jean-Pierre, additional

Published
2021
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42. Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

Author

Nebbioso, Angela, Clarke, Nicole, Voltz, Emilie, Germain, Emmanuelle, Ambrosino, Concetta, Bontempo, Paola, Alvarez, Rosana, Schiavone, Ettore M, Ferrara, Felicetto, Bresciani, Francesco, Weisz, Alessandro, de Lera, Angel R, Gronemeyer, Hinrich, and Altucci, Lucia

Abstract

Author(s): Angela Nebbioso [1]; Nicole Clarke [2]; Emilie Voltz [2]; Emmanuelle Germain [2]; Concetta Ambrosino [1]; Paola Bontempo [1]; Rosana Alvarez [3]; Ettore M Schiavone [4]; Felicetto Ferrara [4]; Francesco [...]

Published
2005
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43. Targeting monoamine oxidase A-regulated TAM polarization for cancer immunotherapy

Author

Wang, Yu-Chen, primary, Wang, Xi, additional, Yu, Jiaji, additional, Ma, Feiyang, additional, Li, Zhe, additional, Zhou, Yang, additional, Zeng, Samuel, additional, Ma, Xiaoya, additional, Li, Yanruide, additional, Neal, Adam, additional, Huang, Jie, additional, To, Angela, additional, Clarke, Nicole, additional, Memarzadeh, Sanaz, additional, Pellegrini, Matteo, additional, and Yang, Lili, additional

Published
2020
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45. GSK3?-SCFFBXW7? mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover

Author

Garvin, Alexander J., Khalaf, Ahmed H.A., Rettino, Alessandro, Xicluna, Jerome, Butler, Laura, Morris, Joanna R., Heery, David M., and Clarke, Nicole M.

Subjects
FBXW7, phosphodegron, GSK3, Interferon Regulatory Factor-1
Abstract

IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcription factors. IRF1 protein expression is regulated by transient up-regulation in response to external stimuli followed by rapid degradation via the ubiquitin-proteasome system. Here we report that DNA bound IRF1 turnover is promoted by GSK3? (Glycogen Synthase Kinase 3?) via phosphorylation of the T181 residue which generates a phosphodegron for the SCF (Skp-Cul-Fbox) ubiquitin E3-ligase receptor protein Fbxw7? (F-box/WD40 7). This regulated turnover is essential for IRF1 activity, as mutation of T181 results in an improperly stabilised protein that accumulates at target promoters but fails to induce RNA-Pol-II elongation and subsequent transcription of target genes. Consequently, the anti-proliferative activity of IRF1 is lost in cell lines expressing T181A mutant. Further, cell lines with dysfunctional Fbxw7 are less sensitive to IRF1 overexpression, suggesting an important co-activator function for this ligase complex. As T181 phosphorylation requires both DNA binding and RNA-Pol-II elongation, we propose that this event acts to clear " spent " molecules of IRF1 from transcriptionally engaged target promoters.

Published
2019

46. Family-friendly backlash - fact or fiction? The case of organizations' on-site child care centers

Author

Rothausen, Teresa J., Gonzalez, Jorge A., Clarke, Nicole E., and O'Dell, Lisa L.

Subjects
Employer-supported day care -- Research, Workers -- Beliefs, opinions and attitudes, Employee benefits -- Research, Human resources and labor relations, Psychology and mental health
Abstract

Employer offerings of on-site child care benefits have grown tremendously in the past few decades; both beneficial and detrimental effects on worker attitudes and behaviors have been noted. Some research suggests that offering on-site child care benefits can cause resentment among childless workers and/or workers with children who do not use the center. In a field sample of 271 employees, current and past use of the on-site child care center, as well as anticipated future use of the on-site child care center, were related to more positive proximal reactions such as attitudes closely related to the on-site child care center, but not to more general attitudes or behaviors. Results indicate that any 'family-friendly backlash' may be limited to proximal reactions. These findings are discussed in light of organizational justice theories. (Reprinted by permission of the publisher.)

Published
1998

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