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This study investigated novel pedagogies for helping teachers infuse inquiry into a standards-based science curriculum. Using a multi-user virtual environment (MUVE) as a pedagogical vehicle, teams of middle-school students collaboratively solved problems around disease in a virtual town called River City. The students interacted with "avatars" of other students, digital artefacts and computer-based "agents" acting as mentors and colleagues in a virtual community of practice set during the time period when bacteria were just being discovered. This paper describes the results from three implementations of the River City virtual environment in 2004-05 with approximately 2000 students from geographically diverse urban areas. The results indicated that students were able to conduct inquiry in virtual worlds and were motivated by that process. However, the results from the assessments varied depending on the assessment strategy employed.

One-size-fits-all educational innovations do not work because they ignore contextual factors that determine an intervention's efficacy in a particular local situation. This paper presents a framework on how to design educational innovations for scalability through enhancing their adaptability for effective usage in a wide variety of settings. The River City multi-user virtual environment (MUVE), a technology-based curriculum designed to enhance engagement and learning in middle school science, is presented as a case study. To date over 250 teachers and 15,000 students throughout the United States and Canada have participated in the River City curriculum. Designers creating and evolving interventions can use this scaling framework to help them increase effectiveness, sustainability, and spread.