Search

Your search keyword '"Clarke, Graham"' showing total 1,535 results
Start Over Author "Clarke, Graham"

Refine your results

more »

more »

more »

more »

more »
1,535 results on '"Clarke, Graham"'

16. NETHERWOOD SIDINGS.

Author

CLARKE, GRAHAM

Subjects
DIESEL multiple units, DIESEL locomotives, RAILROAD trains, PASSENGER trains, ROLLING stock
Abstract

The article discusses the construction and operation of a model railway layout based on the former Great Central Railway Manchester-Sheffield Woodhead route. The layout, called Netherwood Sidings, is built in 7mm:1ft scale and features a small yard where diesel and electric locomotives are swapped. The layout is modular and can be extended for exhibitions. The article also describes the construction of the scenery, the wiring and signaling systems, and the locomotives and rolling stock used on the layout. The author emphasizes the inclusion of interactive features to engage viewers, such as a smoke unit, sound effects, and a modified track worker figure. The layout will be exhibited at upcoming shows. [Extracted from the article]

Published
2024

29. A Psychoanalytic Approach to the Singularity: Why We Cannot Do Without Auxiliary Constructions

Author

Clarke, Graham, Elitzur, Avshalom C., Series editor, Merali, Zeeya, Series editor, Padmanabhan, T., Series editor, Schlosshauer, Maximilian, Series editor, Silverman, Mark P., Series editor, Tuszynski, Jack A, Series editor, Vaas, Rüdiger, Series editor, Callaghan, Victor, editor, Miller, James, editor, Yampolskiy, Roman, editor, and Armstrong, Stuart, editor

Published
2017
Full Text
View/download PDF

38. The SMILE Model: Construction and Calibration

Author

O’Donoghue, Cathal, Farell, Niall, Morrissey, Karyn, Lennon, John, Ballas, Dimitris, Clarke, Graham, Hynes, Stephen, O'Donoghue, Cathal, editor, Ballas, Dimitris, editor, Clarke, Graham, editor, Hynes, Stephen, editor, and Morrissey, Karyn, editor

Published
2013
Full Text
View/download PDF

39. A Review of Microsimulation for Policy Analysis

Author

Ballas, Dimitris, Clarke, Graham, Hynes, Stephen, Lennon, John, Morrissey, Karyn, O’Donoghue, Cathal, O'Donoghue, Cathal, editor, Ballas, Dimitris, editor, Clarke, Graham, editor, Hynes, Stephen, editor, and Morrissey, Karyn, editor

Published
2013
Full Text
View/download PDF

40. Introduction

Author

Ballas, Dimitris, Clarke, Graham, Hynes, Stephen, Morrissey, Karyn, O’Donoghue, Cathal, O'Donoghue, Cathal, editor, Ballas, Dimitris, editor, Clarke, Graham, editor, Hynes, Stephen, editor, and Morrissey, Karyn, editor

Published
2013
Full Text
View/download PDF

41. Spatial Access to Health Services

Author

Morrissey, Karyn, Ballas, Dimitris, Clarke, Graham, Hynes, Stephen, O’Donoghue, Cathal, O'Donoghue, Cathal, editor, Ballas, Dimitris, editor, Clarke, Graham, editor, Hynes, Stephen, editor, and Morrissey, Karyn, editor

Published
2013
Full Text
View/download PDF

42. Conclusions and Next Steps

Author

O’Donoghue, Cathal, Ballas, Dimitris, Clarke, Graham, Hynes, Stephen, Lennon, John, Morrissey, Karyn, O'Donoghue, Cathal, editor, Ballas, Dimitris, editor, Clarke, Graham, editor, Hynes, Stephen, editor, and Morrissey, Karyn, editor

Published
2013
Full Text
View/download PDF

46. Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)

Author

Khaleva, Ekaterina, Rattu, Anna, Brightling, Chris, Bush, Andrew, Bossios, Apostolos, Bourdin, Arnaud, Chung, Kian Fan, Chaudhuri, Rekha, Coleman, Courtney, Dahlén, Sven Erik, Djukanovic, Ratko, Deschildre, Antoine, Fleming, Louise, Fowler, Stephen J., Gupta, Atul, Hamelmann, Eckard, Hashimoto, Simone, Hedlin, Gunilla, Koppelman, Gerard H., Melén, Erik, Murray, Clare S., Pilette, Charles, Porsbjerg, Celeste, Pike, Katharine C., Rusconi, Franca, Williams, Clare, Ahrens, Birgit, Alter, Peter, Anckers, Freja, van den Berge, Maarten, Blumchen, Katharina, Brusselle, Guy, Clarke, Graham W., Cunoosamy, Danen, Dahlén, Barbro, Dixey, Piers, Exley, Andrew, Frey, Urs, Gaillard, Erol A., Giovannini-Chami, Lisa, Grigg, Jonathan, Hartenstein, Diana, Heaney, Liam G., Karadag, Bülent, Kaul, Susanne, Kull, Inger, Licari, Amelia, Maitland-van der Zee, Anke-Hilse, Mahler, Vera, Schoos, Ann Marie M., Nagakumar, Prasad, Negus, Jenny, Nielsen, Hanna, Pijnenburg, Mariëlle, Ramiconi, Valeria, Romagosa Vilarnau, Sofia, Principe, Stefania, Rutjes, Niels W. P., Saglani, Sejal, Seddon, Paul C, Singer, Florian, Staudinger, Heribert, Turner, Steve, Vijverberg, Susanne J, Winders, Tonya, Yasinska, Valentyna, Roberts, Graham, Sverrild, Asger, Lapperre, Therese, Khaleva, Ekaterina, Rattu, Anna, Brightling, Chris, Bush, Andrew, Bossios, Apostolos, Bourdin, Arnaud, Chung, Kian Fan, Chaudhuri, Rekha, Coleman, Courtney, Dahlén, Sven Erik, Djukanovic, Ratko, Deschildre, Antoine, Fleming, Louise, Fowler, Stephen J., Gupta, Atul, Hamelmann, Eckard, Hashimoto, Simone, Hedlin, Gunilla, Koppelman, Gerard H., Melén, Erik, Murray, Clare S., Pilette, Charles, Porsbjerg, Celeste, Pike, Katharine C., Rusconi, Franca, Williams, Clare, Ahrens, Birgit, Alter, Peter, Anckers, Freja, van den Berge, Maarten, Blumchen, Katharina, Brusselle, Guy, Clarke, Graham W., Cunoosamy, Danen, Dahlén, Barbro, Dixey, Piers, Exley, Andrew, Frey, Urs, Gaillard, Erol A., Giovannini-Chami, Lisa, Grigg, Jonathan, Hartenstein, Diana, Heaney, Liam G., Karadag, Bülent, Kaul, Susanne, Kull, Inger, Licari, Amelia, Maitland-van der Zee, Anke-Hilse, Mahler, Vera, Schoos, Ann Marie M., Nagakumar, Prasad, Negus, Jenny, Nielsen, Hanna, Pijnenburg, Mariëlle, Ramiconi, Valeria, Romagosa Vilarnau, Sofia, Principe, Stefania, Rutjes, Niels W. P., Saglani, Sejal, Seddon, Paul C, Singer, Florian, Staudinger, Heribert, Turner, Steve, Vijverberg, Susanne J, Winders, Tonya, Yasinska, Valentyna, Roberts, Graham, Sverrild, Asger, and Lapperre, Therese

Abstract

Background Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) Working Group sought to develop Core Outcome Measures (COM) sets to facilitate better synthesis of data and appraisal of biologics in paediatric and adult asthma clinical studies. Methods COMSA utilised a multi-stakeholder consensus process among patients with severe asthma, adult and paediatric clinicians, pharmaceutical representatives, and health regulators from across Europe. Evidence included a systematic review of development, validity and reliability of selected outcome measures plus a narrative review and a pan-European survey to better understand patients’ and carers’ views about outcome measures. It was discussed using a modified GRADE (Grading of Recommendations Assessment, Development and Evaluation) Evidence to Decision framework. Anonymous voting was conducted using predefined consensus criteria. Results Both adult and paediatric COM sets include forced expiratory volume in 1 s (FEV1) as z-scores, annual frequency of severe exacerbations and maintenance oral corticosteroid use. Additionally, the paediatric COM set includes the Paediatric Asthma Quality of Life Questionnaire and Asthma Control Test or Childhood Asthma Control Test, while the adult COM set includes the Severe Asthma Questionnaire and Asthma Control Questionnaire-6 (symptoms and rescue medication use reported separately). Conclusions This patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma., Background Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) Working Group sought to develop Core Outcome Measures (COM) sets to facilitate better synthesis of data and appraisal of biologics in paediatric and adult asthma clinical studies. Methods COMSA utilised a multi-stakeholder consensus process among patients with severe asthma, adult and paediatric clinicians, pharmaceutical representatives, and health regulators from across Europe. Evidence included a systematic review of development, validity and reliability of selected outcome measures plus a narrative review and a pan-European survey to better understand patients’ and carers’ views about outcome measures. It was discussed using a modified GRADE (Grading of Recommendations Assessment, Development and Evaluation) Evidence to Decision framework. Anonymous voting was conducted using predefined consensus criteria. Results Both adult and paediatric COM sets include forced expiratory volume in 1 s (FEV1) as z-scores, annual frequency of severe exacerbations and maintenance oral corticosteroid use. Additionally, the paediatric COM set includes the Paediatric Asthma Quality of Life Questionnaire and Asthma Control Test or Childhood Asthma Control Test, while the adult COM set includes the Severe Asthma Questionnaire and Asthma Control Questionnaire-6 (symptoms and rescue medication use reported separately). Conclusions This patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma.

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results