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13 results on '"Clarke, Glynnis"'

4. Multiple sclerosis in New Zealand Māori

Author

Pearson, John F, primary, Alla, Sridhar, additional, Clarke, Glynnis, additional, Taylor, Bruce V, additional, Miller, David H, additional, Richardson, Ann, additional, and Mason, Deborah F, additional

Published
2014
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5. Assessing possible selection bias in a national voluntary MS longitudinal study in Australia

Author

Taylor, B V, Palmer, Andrew, Simpson, Steve, NZMSPS , study group, Simmons, Rex, Mason, Deborah, Pearson, John, Clarke, Glynnis, Sabel, Clive, Willoughby, Ernie, Abernethy, David, Lucas, Robyn, Taylor, B V, Palmer, Andrew, Simpson, Steve, NZMSPS , study group, Simmons, Rex, Mason, Deborah, Pearson, John, Clarke, Glynnis, Sabel, Clive, Willoughby, Ernie, Abernethy, David, and Lucas, Robyn

Abstract

Background: Surveying volunteer members of a multiple sclerosis registry is a very cost-effective way of assessing the impact of the disease on life outcomes. However, whether the data from such a study can be generalised to the whole population of person

Published
2013

6. Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

Author

Myles Axton, Bahlo, Melanie, Booth, David R., Broadley, Simon A., Brown, Matthew A., Foote, Simon J., Griffiths, Lyn R., Kilpatrick, Trevour J., Lechner-Scott, Jeanette, Moscato, Pablo, Perreau, Victoria M., Rubio, Justin P., Scott, Rodney J., Stankovich, Jim, Stewart, Graeme J., Taylor, Bruce V., Wiley, James, Clarke, Glynnis, Cox, Mathew B., Csurhes, Peter A., Danoy, Patrick, Drysdale, Karen, Field, Judith, Greer, Judith M., Griffiths, Lyn R, Hadler, Johanna, McMorran, Brendan J., Jensen, Cathy J., Johnson, Laura J., McCallum, Ruth, Merriman, Marilyn, Merriman, Tony, Pryce, Karena, Tajouri, Lotfi, Wilkins, Ella J., Browning, Brian L., Browning, Sharon R., Perera, Devindri, Butzkueven, Helmut, Carroll, William M., Chapman, Caron, Kermode, Allan G., Marriott, Mark, Mason, Deborah, Heard, Robert N., Pender, Michael P., Slee, Mark, Tubridy, Niall, Willoughby, Ernest, Myles Axton, Bahlo, Melanie, Booth, David R., Broadley, Simon A., Brown, Matthew A., Foote, Simon J., Griffiths, Lyn R., Kilpatrick, Trevour J., Lechner-Scott, Jeanette, Moscato, Pablo, Perreau, Victoria M., Rubio, Justin P., Scott, Rodney J., Stankovich, Jim, Stewart, Graeme J., Taylor, Bruce V., Wiley, James, Clarke, Glynnis, Cox, Mathew B., Csurhes, Peter A., Danoy, Patrick, Drysdale, Karen, Field, Judith, Greer, Judith M., Griffiths, Lyn R, Hadler, Johanna, McMorran, Brendan J., Jensen, Cathy J., Johnson, Laura J., McCallum, Ruth, Merriman, Marilyn, Merriman, Tony, Pryce, Karena, Tajouri, Lotfi, Wilkins, Ella J., Browning, Brian L., Browning, Sharon R., Perera, Devindri, Butzkueven, Helmut, Carroll, William M., Chapman, Caron, Kermode, Allan G., Marriott, Mark, Mason, Deborah, Heard, Robert N., Pender, Michael P., Slee, Mark, Tubridy, Niall, and Willoughby, Ernest

Abstract

To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an independent set of 2,256 cases and 2,310 controls, for a total of 3,874 cases and 5,723 controls. We identified risk-associated SNPs on chromosome 12q13-14 (rs703842, P = 5.4 x 10(-11); rs10876994, P = 2.7 x 10(-10); rs12368653, P = 1.0 x 10(-7)) and upstream of CD40 on chromosome 20q13 (rs6074022, P = 1.3 x 10(-7); rs1569723, P = 2.9 x 10(-7)). Both loci are also associated with other autoimmune diseases. We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).

Published
2009

11. Assessing possible selection bias in a national voluntary MS longitudinal study in Australia.

Author

Taylor, Bruce V, Palmer, Andrew, Simpson, Steve, Lucas, Robyn, Simmons, Rex D, Mason, Deborah, Pearson, John, Clarke, Glynnis, Sabel, Clive, Willoughby, Ernie, Richardson, Anne, and Abernethy, David

Subjects
MULTIPLE sclerosis, RESEARCH bias, QUALITY of life, LONGITUDINAL method, PATIENTS
Abstract

The article discusses a study on the assessment of the impacts of multiple sclerosis (MS) in the lives of the MS disease carriers in Australia. The study uses a cost-effective assessment strategy by conducting surveys from the volunteer members of an MS registry. It says that the strategy may exhibit different outcomes resulting to the prevalence of volunteer bias. It adds that the Australian Multiple Sclerosis Longitudinal Study (AMSLS) was determined essential in the country's MS population.

Published
2013
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12. An investigation of the relationship between latitude and multiple sclerosis severity in New Zealand.

Author

Alla, Sridhar, Pearson, John F., Taylor, Bruce V., Roxburgh, Richard, Clarke, Glynnis, Miller, David H., Richardson, Ann, Abernethy, David A., Willoughby, Ernie, Sabel, Clive E., and Mason, Deborah F.

Subjects
MULTIPLE sclerosis, LATITUDE, DISEASE prevalence, SEVERITY of illness index, PUBLIC health
Abstract

The article discusses a study which investigated whether there is a link between latitude and severity of multiple sclerosis. Topics covered include data acquired in the 2006 New Zealand National Multiple Sclerosis Prevalence Study (NZMSPS), and findings which suggest that there is a strong and direct relationship of latitude with prevalence, but a weak inverse relationship with disease severity.

Published
2016
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13. Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.

Author

Bahlo, Melanie, Booth, David R, Broadley, Simon A, Brown, Matthew A, Foote, Simon J, Griffiths, Lyn R, Kilpatrick, Trevor J, Lechner-Scott, Jeanette, Moscato, Pablo, Perreau, Victoria M, Rubio, Justin P, Scott, Rodney J, Stankovich, Jim, Stewart, Graeme J, Taylor, Bruce V, Wiley, James, Clarke, Glynnis, Cox, Mathew B, Csurhes, Peter A, and Danoy, Patrick

Subjects
MULTIPLE sclerosis, LOCUS (Genetics), GENOMES, AUTOIMMUNE diseases, CHROMOSOMES, GENETICS
Abstract

To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an independent set of 2,256 cases and 2,310 controls, for a total of 3,874 cases and 5,723 controls. We identified risk-associated SNPs on chromosome 12q13–14 (rs703842, P = 5.4 × 10−11; rs10876994, P = 2.7 × 10−10; rs12368653, P = 1.0 × 10−7) and upstream of CD40 on chromosome 20q13 (rs6074022, P = 1.3 × 10−7; rs1569723, P = 2.9 × 10−7). Both loci are also associated with other autoimmune diseases. We also replicated several known MS associations (HLA-DR15, P = 7.0 × 10−184; CD58, P = 9.6 × 10−8; EVI5-RPL5, P = 2.5 × 10−6; IL2RA, P = 7.4 × 10−6; CLEC16A, P = 1.1 × 10−4; IL7R, P = 1.3 × 10−3; TYK2, P = 3.5 × 10−3) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001). [ABSTRACT FROM AUTHOR]

Published
2009
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