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2. Long-term Outcomes with Spinal versus General Anesthesia for Hip Fracture Surgery: A Randomized Trial

Author

Vail, Emily A., Feng, Rui, Sieber, Frederick, Carson, Jeffrey L., Ellenberg, Susan S., Magaziner, Jay, Dillane, Derek, Marcantonio, Edward R., Sessler, Daniel I., Ayad, Sabry, Stone, Trevor, Papp, Steven, Donegan, Derek, Mehta, Samir, Schwenk, Eric S., Marshall, Mitchell, Jaffe, J. Douglas, Luke, Charles, Sharma, Balram, Azim, Syed, Hymes, Robert, Chin, Ki-Jinn, Sheppard, Richard, Perlman, Barry, Sappenfield, Joshua, Hauck, Ellen, Tierney, Ann, Horan, Annamarie D., Neuman, Mark D., Looke, Thomas, Bent, Sandra, Franco-Mora, Ariana, Hedrick, Pamela, Newbern, Matthew, Tadros, Rafik, Pealer, Karen, Vlassakov, Kamen, Buckley, Carolyn, Gavin, Lauren, Gorbatov, Svetlana, Gosnell, James, Steen, Talora, Vafai, Avery, Zeballos, Jose, Hruslinski, Jennifer, Cardenas, Louis, Berry, Ashley, Getchell, John, Quercetti, Nicholas, Hassan, Manal, Bajracharya, Gauasan, Billow, Damien, Bloomfield, Michael, Cuko, Evis, Elyaderani, Mehrun K., Hampton, Robert, Honar, Hooman, Khoshknabi, Dilara, Kim, Daniel, Krahe, David, Lew, Michael M., Maheshwer, Conjeevram B., Niazi, Azfar, Saha, Partha, Salih, Ahmed, de Swart, Robert J., Volio, Andrew, Bolkus, Kelly, DeAngelis, Matthew, Dodson, Gregory, Gerritsen, Jeffrey, McEniry, Brian, Mitrev, Ludmil, Kwofie, M. Kwesi, Belliveau, Anne, Bonazza, Flynn, Lloyd, Vera, Panek, Izabela, Dabiri, Jared, Chavez, Chris, Craig, Jason, Davidson, Todd, Dietrichs, Chad, Fleetwood, Cheryl, Foley, Mike, Getto, Chris, Hailes, Susie, Hermes, Sarah, Hooper, Andy, Koener, Greg, Kohls, Kate, Law, Leslie, Lipp, Adam, Losey, Allison, Nelson, William, Nieto, Mario, Rogers, Pam, Rutman, Steve, Scales, Garrett, Sebastian, Barbara, Stanciu, Tom, Lobel, Gregg, Giampiccolo, Michelle, Herman, Dara, Kaufman, Margit, Murphy, Bryan, Pau, Clara, Puzio, Thomas, Veselsky, Marlene, Apostle, Kelly, Boyer, Dory, Chen Fan, Brenda, Lee, Susan, Lemke, Mike, Merchant, Richard, Moola, Farhad, Payne, Kyrsten, Perey, Bertrand, Viskontas, Darius, Poler, Mark, D’Antonio, Patricia, O’Neill, Greg, Abdullah, Amer, Fish-Fuhrmann, Jamie, Giska, Mark, Fidkowski, Christina, Guthrie, Stuart Trent, Hakeos, William, Hayes, Lillian, Hoegler, Joseph, Nowak, Katherine, Beck, Jeffery, Cuff, Jaslynn, Gaski, Greg, Haaser, Sharon, Holzman, Michael, Malekzadeh, A. Stephen, Ramsey, Lolita, Schulman, Jeff, Schwartzbach, Cary, Azefor, Tangwan, Davani, Arman, Jaberi, Mahmood, Masear, Courtney, Haider, Syed Basit, Chungu, Carolyn, Ebrahimi, Ali, Fikry, Karim, Marcantonio, Andrew, Shelvan, Anitha, Sanders, David, Clarke, Collin, Lawendy, Abdel, Schwartz, Gary, Garg, Mohit, Kim, Joseph, Caruci, Juan, Commeh, Ekow, Cuevas, Randy, Cuff, Germaine, Franco, Lola, Furgiuele, David, Giuca, Matthew, Allman, Melissa, Barzideh, Omid, Cossaro, James, D’Arduini, Armando, Farhi, Anita, Gould, Jason, Kafel, John, Patel, Anuj, Peller, Abraham, Reshef, Hadas, Safur, Mohammed, Toscano, Fiore, Tedore, Tiffany, Akerman, Michael, Brumberger, Eric, Clark, Sunday, Friedlander, Rachel, Jegarl, Anita, Lane, Joseph, Lyden, John P., Mehta, Nili, Murrell, Matthew T., Painter, Nathan, Ricci, William, Sbrollini, Kaitlyn, Sharma, Rahul, Steel, Peter A.D., Steinkamp, Michele, Weinberg, Roniel, Stephenson Wellman, David, Nader, Antoun, Fitzgerald, Paul, Ritz, Michaela, Bryson, Greg, Craig, Alexandra, Farhat, Cassandra, Gammon, Braden, Gofton, Wade, Harris, Nicole, Lalonde, Karl, Liew, Allan, Meulenkamp, Bradley, Sonnenburg, Kendra, Wai, Eugene, Wilkin, Geoffrey, Troxell, Karen, Alderfer, Mary Ellen, Brannen, Jason, Cupitt, Christopher, Gerhart, Stacy, McLin, Renee, Sheidy, Julie, Yurick, Katherine, Chen, Fei, Dragert, Karen, Kiss, Geza, Malveaux, Halina, McCloskey, Deborah, Mellender, Scott, Mungekar, Sagar S., Noveck, Helaine, Sagebien, Carlos, Biby, Luat, McKelvy, Gail, Richards, Anna, Abola, Ramon, Ayala, Brittney, Halper, Darcy, Mavarez, Ana, Rizwan, Sabeen, Choi, Stephen, Awad, Imad, Flynn, Brendan, Henry, Patrick, Jenkinson, Richard, Kaustov, Lilia, Lappin, Elizabeth, McHardy, Paul, Singh, Amara, Donnelly, Joanne, Gonzalez, Meera, Haydel, Christopher, Livelsberger, Jon, Pazionis, Theresa, Slattery, Bridget, Vazquez-Trejo, Maritza, Baratta, Jaime, Cirullo, Michael, Deiling, Brittany, Deschamps, Laura, Glick, Michael, Katz, Daniel, Krieg, James, Lessin, Jennifer, Mojica, Jeffrey, Torjman, Marc, Jin, Rongyu, Salpeter, Mary Jane, Powell, Mark, Simmons, Jeffrey, Lawson, Prentiss, Kukreja, Promil, Graves, Shanna, Sturdivant, Adam, Bryant, Ayesha, Crump, Sandra Joyce, Verrier, Michelle, Green, James, Menon, Matthew, Applegate, Richard, Arias, Ana, Pineiro, Natasha, Uppington, Jeffrey, Wolinsky, Phillip, Gunnett, Amy, Hagen, Jennifer, Harris, Sara, Hollen, Kevin, Holloway, Brian, Horodyski, Mary Beth, Pogue, Trevor, Ramani, Ramachandran, Smith, Cameron, Woods, Anna, Warrick, Matthew, Flynn, Kelly, Mongan, Paul, Ranganath, Yatish, Fernholz, Sean, Ingersoll-Weng, Esperanza, Marian, Anil, Seering, Melinda, Sibenaller, Zita, Stout, Lori, Wagner, Allison, Walter, Alicia, Wong, Cynthia, Orwig, Denise, Goud, Maithri, Helker, Chris, Mezenghie, Lydia, Montgomery, Brittany, Preston, Peter, Schwartz, J. Sanford, Weber, Ramona, Fleisher, Lee A., Mehta, Samir, Stephens-Shields, Alisa J., Dinh, Cassandra, Schwartz, Aron, Chelly, Jacques E., Goel, Shiv, Goncz, Wende, Kawabe, Touichi, Khetarpal, Sharad, Monroe, Amy, Shick, Vladislav, Breidenstein, Max, Dominick, Timothy, Friend, Alexander, Mathews, Donald, Lennertz, Richard, Sanders, Robert, Akere, Helen, Balweg, Tyler, Bo, Amber, Doro, Christopher, Goodspeed, David, Lang, Gerald, Parker, Maggie, Rettammel, Amy, Roth, Mary, White, Marissa, Whiting, Paul, Allen, Brian F.S., Baker, Tracie, Craven, Debra, McEvoy, Matt, Turnbo, Teresa, Kates, Stephen, Morgan, Melanie, Willoughby, Teresa, Weigel, Wade, Auyong, David, Fox, Ellie, Welsh, Tina, Cusson, Bruce, Dobson, Sean, Edwards, Christopher, Harris, Lynette, Henshaw, Daryl, Johnson, Kathleen, McKinney, Glen, Miller, Scott, Reynolds, Jon, Segal, B. Scott, Turner, Jimmy, VanEenenaam, David, Weller, Robert, Lei, Jineli, Treggiari, Miriam, Akhtar, Shamsuddin, Blessing, Marcelle, Johnson, Chanel, Kampp, Michael, Kunze, Kimberly, OʼConnor, Mary, Gaskins, Lakisha J., Looke, Thomas, Tadros, Rafik, Vlassakov, Kamen, Cardenas, Louis, Hassan, Manal, Bolkus, Kelly, Mitrev, Ludmil, Kwofie, M. Kwesi, Dabiri, Jared, Lobel, Gregg, Poler, Mark, Giska, Mark, Sanders, David, Schwartz, Gary, Giuca, Matthew, Tedore, Tiffany, Nader, Antoun, Papp, Stephen, Bryson, Greg, Troxell, Karen, Kiss, Geza, Choi, Stephen, Powell, Mark, Applegate, Richard, Warrick, Matthew, Ranganath, Yatish, Elkassabany, Nabil, Chelly, Jacques E., Hoeft, Mark A., Lennertz, Richard, Sanders, Robert, Allen, Brian F.S., Kates, Stephen, Weigel, Wade, Li, Jinlei, Wijeysundera, Duminda N., Kheterpal, Sachin, Moore, Reneé H., Smith, Alexander K., Tosi, Laura L., Elkassabany, Nabil, Looke, Thomas, Menio, Diane, Mehta, Samir, Fleisher, Lee, Menio, Diane, Hruslinski, Jennifer, Ramsey, Lolita, Gaskins, Lakisha J., Langlois, Christine, Gaskins, Lakisha J., Mezenghie, Lydia, Montgomery, Brittany, Oduwole, Samuel, and Rose, Thomas

Published
2024
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4. Engaging patients as partners in a multicentre trial of spinal versus general anaesthesia for older adults

Author

Looke, Thomas, Bent, Sandra, Franco-Mora, Ariana, Hedrick, Pamela, Newbern, Matthew, Tadros, Rafik, Pealer, Karen, Marcantonio, Edward, Vlassakov, Kamen, Buckley, Carolyn, Gorbatov, Svetlana, Gosnell, James, Steen, Talora, Vafai, Avery, Zeballos, Jose, Cardenas, Louis, Berry, Ashley, Getchell, John, Quercetti, Nicholas, Sessler, Daniel I., Ayad, Sabry, Hassan, Manal, Ali, Assad, Bajracharya, Gauasan, Billow, Damien, Bloomfield, Michael, Elliott, Kavita, Hampton, Robert, He, Linda, Honar, Hooman, Khoshknabi, Dilara, Kim, Daniel, Minko, Paul, Morris, Adam, Niazi, Azfar, Nutcharoen, Tara, Roberts, Jeffrey, Saha, Partha, Salih, Ahmed, Skolaris, Alexis, Stang, Taylor, Strimbu, Victor, Templeton, Jesse, Volio, Andrew, Wang, Jiayi, Bolkus, Kelly, DeAngelis, Matthew, Dodson, Gregory, Gerritsen, Jeffrey, McEniry, Brian, Mitrev, Ludmil, Kwofie, Kwesi, Bonazza, Flynn, Lloyd, Vera, Panek, Izabela, Dabiri, Jared, Chavez, Chris, Craig, Jason, Davidson, Todd, Dietrichs, Chad, Fleetwood, Cheryl, Foley, Mike, Getto, Chris, Hailes, Susie, Hermes, Sarah, Hooper, Andy, Koener, Greg, Kohls, Kate, Law, Leslie, Lipp, Adam, Losey, Allison, Nelson, William, Nieto, Mario, Rogers, Pam, Rutman, Steve, Scales, Garrett, Sebastian, Barbara, Stanciu, Tom, Lobel, Gregg, Giampiccolo, Michelle, Herman, Dara, Kaufman, Margit, Murphy, Bryan, Pau, Clara, Puzio, Thomas, Veselsky, Marlene, Stone, Trevor, Apostle, Kelly, Boyer, Dory, Fan, Brenda Chen, Lee, Susan, Lemke, Mike, Merchant, Richard, Moola, Farhad, Payne, Kyrsten, Perey, Bertrand, Viskontas, Darius, Poler, Mark, D'Antonio, Patricia, Sheppard, Richard, Abdullah, Amer, Fish-Fuhrmann, Jamie, Giska, Mark, Fidkowski, Christina, Guthrie, Trent, Hakeos, William, Hayes, Lillian, Hoegler, Joseph, Nowak, Katherine, Hymes, Robert, Beck, Jeffery, Cuff, Jaslynn, Gaski, Greg, Haaser, Sharon, Holzman, Michael, Malekzadeh, A. Stephen, Ramsey, Lolita, Schulman, Jeff, Schwartzbach, Cary, Sieber, Frederick, Azefor, Tangwan, Brown, Charles, Davani, Arman, Jaberi, Mahmood, Masear, Courtney, Sharma, Balram, Haider, Syed Basit, Chungu, Carolyn, Ebrahimi, Ali, Fikry, Karim, Gannon, Kerri, Marcantonio, Andrew, Pace, Meredith, Sanders, David, Clarke, Collin, Lawendy, Abdel, Schwartz, Gary, Garg, Mohit, Kim, Joseph, Marshall, Mitchell, Caurci, Juan, Commeh, Ekow, Cuevas, Randy, Cuff, Germaine, Franco, Lola, Furguiele, David, Giuca, Matthew, Allman, Melissa, Barzideh, Omid, Cossaro, James, D'Arduini, Armando, Farhi, Anita, Gould, Jason, Kafel, John, Patel, Anuj, Peller, Abraham, Reshef, Hadas, Safur, Mohammed, Toscano, Fiore, Tedore, Tiffany, Akerman, Michael, Brumberger, Eric, Clark, Sunday, Friedlander, Rachel, Jegarl, Anita, Lane, Joseph, Lyden, John P., Mehta, Nili, Murrell, Matthew T., Painter, Nathan, Ricci, William, Sbrollini, Kaitlyn, Sharma, Rahul, Steel, Peter A.D., Steinkamp, Michele, Weinberg, Roniel, Wellman, David Stephenson, Nader, Antoun, Fitzgerald, Paul, Ritz, Michaela, Papp, Steven, Bryson, Greg, Craig, Alexandra, Farhat, Cassandra, Gammon, Braden, Gofton, Wade, Harris, Nicole, Lalonde, Karl, Liew, Allan, Meulenkamp, Bradley, Sonnenburg, Kendra, Wai, Eugene, Wilkin, Geoffrey, Donegan, Derek, Dinh, Cassandra, Elkassabany, Nabil, Horan, Annamarie, Mehta, Samir, Troxell, Karen, Alderfer, Mary Ellen, Brannen, Jason, Cupitt, Christopher, Gerhart, Stacy, McLin, Renee, Sheidy, Julie, Yurick, Katherine, Carson, Jeffrey, Chen, Fei, Dragert, Karen, Kiss, Geza, Malveaux, Halina, McCloskey, Deborah, Mellender, Scott, Mungekar, Sagar S., Noveck, Helaine, Sagebien, Carlos, Perlman, Barry, Biby, Luat, McKelvy, Gail, Richards, Anna, Azim, Syed, Abola, Ramon, Ayala, Brittney, Halper, Darcy, Mavarez, Ana, Choi, Stephen, Awad, Imad, Flynn, Brendan, Henry, Patrick, Jenkinson, Richard, Kaustov, Lilia, Lappin, Elizabeth, McHardy, Paul, Singh, Amara, Hauck, Ellen, Donnelly, Joanne, Gonzalez, Meera, Haydel, Christopher, Livelsberger, Jon, Pazionis, Theresa, Slattery, Bridget, Vazquez-Trejo, Maritza, Schwenk, Eric, Baratta, Jaime, Deiling, Brittany, Deschamps, Laura, Glick, Michael, Katz, Daniel, Krieg, James, Lessin, Jennifer, Torjman, Marc, Chin, Ki Jinn, Jin, Rongyu, Salpeter, Mary Jane, Powell, Mark, Simmons, Jeffrey, Lawson, Prentiss, Kukreja, Promil, Graves, Shanna, Sturdivant, Adam, Bryant, Ayesha, Crump, Sandra Joyce, Dillane, Derek, Taylor, Michael, Verrier, Michelle, Applegate, Richard, Arias, Ana, Pineiro, Natasha, Uppington, Jeffrey, Wolinsky, Phillip, Sappenfield, Joshua, Gunnett, Amy, Hagen, Jennifer, Harris, Sara, Hollen, Kevin, Holloway, Brian, Horodyski, Mary Beth, Pogue, Trevor, Ramani, Ramachandran, Smith, Cameron, Woods, Anna, Warrick, Matthew, Flynn, Kelly, Mongan, Paul, Ranganath, Yatish, Fernholz, Sean, Ingersoll-Weng, Esperanza, Marian, Anil, Seering, Melinda, Sibenaller, Zita, Stout, Lori, Wagner, Allison, Walter, Alicia, Wong, Cynthia, Magaziner, Jay, Orwig, Denise, Brown, Trina, Dattilo, Jim, Ellenberg, Susan, Feng, Rui, Fleisher, Lee, Gaskins, Lakisha, Goud, Maithri, Helker, Chris, Mezenghie, Lydia, Montgomery, Brittany, Preston, Peter, Stephens, Alisa, Schwartz, J. Sanford, Tierney, Ann, Weber, Ramona, Chelly, Jacques, Goel, Shiv, Goncz, Wende, Kawabe, Touichi, Khetarpal, Sharad, King, Kevin, Kunkel, Frank, Luke, Charles, Monroe, Amy, Shick, Vladislav, Silipo, Anthony, Stehle, Caroline, Szabo, Katherine, Yennam, Sudhakar, Hoeft, Mark, Breidenstein, Max, Dominick, Timothy, Friend, Alexander, Mathews, Donald, Lennertz, Richard, Akere, Helen, Balweg, Tyler, Bo, Amber, Doro, Christopher, Goodspeed, David, Lang, Gerald, Parker, Maggie, Rettammel, Amy, Roth, Mary, Sanders, Robert, White, Marissa, Whiting, Paul, Allen, Brian, Baker, Tracie, Craven, Debra, McEvoy, Matt, Turnbo, Teresa, Kates, Stephen, Morgan, Melanie, Willoughby, Teresa, Weigel, Wade, Auyong, David, Fox, Ellie, Welsh, Tina, Jaffe, J. Douglas, Cusson, Bruce, Dobson, Sean, Edwards, Christopher, Harris, Lynette, Henshaw, Daryl, Johnson, Kathleen, McKinney, Glen, Miller, Scott, Reynolds, Jon, Turner, Jimmy, VanEenenaam, David, Weller, Robert, Akhtar, Shamsuddin, Blessing, Marcelle, Johnson, Chanel, Kampp, Michael, Kunze, Kimberly, Li, Jinlei, O'Connor, Mary, Treggiari, Miriam, Hruslinski, Jennifer, Menio, Diane A., Hymes, Robert A., Langlois, Christine, Gaskins, Lakisha J., and Neuman, Mark D.

Published
2021
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12. Development and evaluation of an open-source virtual reality C-Arm simulator.

Author

Allen, Daniel R., Clarke, Collin, Peters, Terry M., and Chen, Elvis C.S

Subjects
IONIZING radiation, RESIDENTS (Medicine), X-ray imaging, LIKERT scale, TEST validity
Abstract

C-Arm positioning for interventional spine procedures is often associated with a steep learning curve. This task requires mentally reconstructing 3D surgical tools and patient anatomy from a 2D X-ray image, which is non-trivial and acquired through years of experience. Standard training via apprenticeship-based programs must be limited due to the unnecessary exposure to ionizing radiation. To this end, we propose a Virtual Reality C-Arm simulator for interventional spine procedure training. We implemented the simulator as an open-source module in Slicer, and evaluated its efficacy through a user study, recruiting medical residents and expert clinicians. Users showed an overall significant improvement in C-Arm placement with regards to angular accuracy (mean ~2 degree improvement), and total procedure time (mean 11 minutes less time). The face and content validity was evaluated positively through a Likert scale questionnaire, with a mean score of 4 (out of 5) or higher for each of the questions. The results show the simulator provides effective training for C-Arm positioning, while eliminating the exposure to ionizing radiation associated with the current training standard. Although this work is catered towards spinal procedures, the system is extendable to other fields, such as cardiac and orthopaedic, and will be explored in future works. [ABSTRACT FROM AUTHOR]

Published
2023
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14. sj-pdf-1-bjp-10.1177_20494637211032907 – Supplemental material for Opioid use after outpatient elective general surgery: quantifying the burden of persistent use

Author

Clarke, Collin, McClure, Andrew, Allen, Laura, Hartford, Luke, Van Koughnett, Julie Ann, Gray, Daryl, Murphy, Patrick B, Vinden, Chris, Leslie, Ken, and Vogt, Kelly N

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-bjp-10.1177_20494637211032907 for Opioid use after outpatient elective general surgery: quantifying the burden of persistent use by Collin Clarke, Andrew McClure, Laura Allen, Luke Hartford, Julie Ann Van Koughnett, Daryl Gray, Patrick B Murphy, Chris Vinden, Ken Leslie and Kelly N Vogt in British Journal of Pain

Published
2022
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20. Contributors

Author

Azari, Pari, primary, Carlson, Jonathan D., additional, Clarke, Collin F.M., additional, Cornidez, Eric G., additional, Field, Justin S., additional, Hogan, Patrick W., additional, Huh, Billy K., additional, Kalfas, Iain H., additional, Kuo, Chang Po, additional, Lynch, Paul J., additional, Makas, Christi, additional, McJunkin, Tory L., additional, Patil, Parag G., additional, Pico, Tristan C., additional, Pope, Jason E., additional, Ranson, Matthew T., additional, Srejic, Elizabeth, additional, and Thompson, William C., additional

Published
2012
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22. Opioid use after outpatient elective general surgery: quantifying the burden of persistent use.

Author

Clarke, Collin, McClure, Andrew, Allen, Laura, Hartford, Luke, Van Koughnett, Julie Ann, Gray, Daryl, Murphy, Patrick B, Vinden, Chris, Leslie, Ken, and Vogt, Kelly N

Subjects
*ELECTIVE surgery, *HERNIA surgery, *CHOLECYSTECTOMY, *INGUINAL hernia, *OPIOIDS, *DRUG prescribing, *INAPPROPRIATE prescribing (Medicine)
Abstract

Purpose: Surgery is a major risk factor for chronic opioid use among patients who had not recently been prescribed opioids. This study identifies the rate of, and risk factors for, persistent opioid use following laparoscopic cholecystectomy and open inguinal hernia repair in patients not recently prescribed opioids. Methods: This retrospective population-based cohort study included all patients who had not been prescribed opioids in the 6 months prior to undergoing open inguinal hernia repair or laparoscopic cholecystectomy from January 2013 to July 2016 in Ontario. Opioid prescription was identified from the provincial Narcotics Monitoring System and data were obtained from the Institute for Clinical Evaluative Sciences. The primary outcome was persistent opioid use after surgery (3, 6, 9 and 12 months). Associated risk factors and prescribing patterns were also examined. Results: Among the 90,326 patients in the study cohort, 80% filled an opioid prescription after surgery, with 11%, 9%, 5% and 1% filling a prescription at 3, 6, 9 and 12 months, respectively. Significant variability was identified in the type of opioid prescribed (41% codeine, 31% oxycodone, 18% tramadol) and in regional prescribing patterns (mean prescription/region range, 135–225 oral morphine equivalents). Predictors of continued opioid use included age, female gender, lower income quintile and being operated on by less experienced surgeons. Conclusion: Most patients who undergo elective cholecystectomy and hernia repair will fill a prescription for an opioid after surgery, and many will continue to fill opioid prescriptions for considerably longer than clinically anticipated. There is important variability in opioid type, regional prescribing patterns and risk factors that identify strategic targets to reduce the opioid burden in this patient population. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Engaging patients as partners in a multicentre trial of spinal versus general anaesthesia for older adults

Author

Hruslinski, Jennifer, primary, Menio, Diane A., additional, Hymes, Robert A., additional, Jaffe, J. Douglas, additional, Langlois, Christine, additional, Ramsey, Lolita, additional, Gaskins, Lakisha J., additional, Neuman, Mark D., additional, Looke, Thomas, additional, Bent, Sandra, additional, Franco-Mora, Ariana, additional, Hedrick, Pamela, additional, Newbern, Matthew, additional, Tadros, Rafik, additional, Pealer, Karen, additional, Marcantonio, Edward, additional, Vlassakov, Kamen, additional, Buckley, Carolyn, additional, Gorbatov, Svetlana, additional, Gosnell, James, additional, Steen, Talora, additional, Vafai, Avery, additional, Zeballos, Jose, additional, Cardenas, Louis, additional, Berry, Ashley, additional, Getchell, John, additional, Quercetti, Nicholas, additional, Sessler, Daniel I., additional, Ayad, Sabry, additional, Hassan, Manal, additional, Ali, Assad, additional, Bajracharya, Gauasan, additional, Billow, Damien, additional, Bloomfield, Michael, additional, Elliott, Kavita, additional, Hampton, Robert, additional, He, Linda, additional, Honar, Hooman, additional, Khoshknabi, Dilara, additional, Kim, Daniel, additional, Minko, Paul, additional, Morris, Adam, additional, Niazi, Azfar, additional, Nutcharoen, Tara, additional, Roberts, Jeffrey, additional, Saha, Partha, additional, Salih, Ahmed, additional, Skolaris, Alexis, additional, Stang, Taylor, additional, Strimbu, Victor, additional, Templeton, Jesse, additional, Volio, Andrew, additional, Wang, Jiayi, additional, Bolkus, Kelly, additional, DeAngelis, Matthew, additional, Dodson, Gregory, additional, Gerritsen, Jeffrey, additional, McEniry, Brian, additional, Mitrev, Ludmil, additional, Kwofie, Kwesi, additional, Bonazza, Flynn, additional, Lloyd, Vera, additional, Panek, Izabela, additional, Dabiri, Jared, additional, Chavez, Chris, additional, Craig, Jason, additional, Davidson, Todd, additional, Dietrichs, Chad, additional, Fleetwood, Cheryl, additional, Foley, Mike, additional, Getto, Chris, additional, Hailes, Susie, additional, Hermes, Sarah, additional, Hooper, Andy, additional, Koener, Greg, additional, Kohls, Kate, additional, Law, Leslie, additional, Lipp, Adam, additional, Losey, Allison, additional, Nelson, William, additional, Nieto, Mario, additional, Rogers, Pam, additional, Rutman, Steve, additional, Scales, Garrett, additional, Sebastian, Barbara, additional, Stanciu, Tom, additional, Lobel, Gregg, additional, Giampiccolo, Michelle, additional, Herman, Dara, additional, Kaufman, Margit, additional, Murphy, Bryan, additional, Pau, Clara, additional, Puzio, Thomas, additional, Veselsky, Marlene, additional, Stone, Trevor, additional, Apostle, Kelly, additional, Boyer, Dory, additional, Fan, Brenda Chen, additional, Lee, Susan, additional, Lemke, Mike, additional, Merchant, Richard, additional, Moola, Farhad, additional, Payne, Kyrsten, additional, Perey, Bertrand, additional, Viskontas, Darius, additional, Poler, Mark, additional, D'Antonio, Patricia, additional, Sheppard, Richard, additional, Abdullah, Amer, additional, Fish-Fuhrmann, Jamie, additional, Giska, Mark, additional, Fidkowski, Christina, additional, Guthrie, Trent, additional, Hakeos, William, additional, Hayes, Lillian, additional, Hoegler, Joseph, additional, Nowak, Katherine, additional, Hymes, Robert, additional, Beck, Jeffery, additional, Cuff, Jaslynn, additional, Gaski, Greg, additional, Haaser, Sharon, additional, Holzman, Michael, additional, Malekzadeh, A. Stephen, additional, Schulman, Jeff, additional, Schwartzbach, Cary, additional, Sieber, Frederick, additional, Azefor, Tangwan, additional, Brown, Charles, additional, Davani, Arman, additional, Jaberi, Mahmood, additional, Masear, Courtney, additional, Sharma, Balram, additional, Haider, Syed Basit, additional, Chungu, Carolyn, additional, Ebrahimi, Ali, additional, Fikry, Karim, additional, Gannon, Kerri, additional, Marcantonio, Andrew, additional, Pace, Meredith, additional, Sanders, David, additional, Clarke, Collin, additional, Lawendy, Abdel, additional, Schwartz, Gary, additional, Garg, Mohit, additional, Kim, Joseph, additional, Marshall, Mitchell, additional, Caurci, Juan, additional, Commeh, Ekow, additional, Cuevas, Randy, additional, Cuff, Germaine, additional, Franco, Lola, additional, Furguiele, David, additional, Giuca, Matthew, additional, Allman, Melissa, additional, Barzideh, Omid, additional, Cossaro, James, additional, D'Arduini, Armando, additional, Farhi, Anita, additional, Gould, Jason, additional, Kafel, John, additional, Patel, Anuj, additional, Peller, Abraham, additional, Reshef, Hadas, additional, Safur, Mohammed, additional, Toscano, Fiore, additional, Tedore, Tiffany, additional, Akerman, Michael, additional, Brumberger, Eric, additional, Clark, Sunday, additional, Friedlander, Rachel, additional, Jegarl, Anita, additional, Lane, Joseph, additional, Lyden, John P., additional, Mehta, Nili, additional, Murrell, Matthew T., additional, Painter, Nathan, additional, Ricci, William, additional, Sbrollini, Kaitlyn, additional, Sharma, Rahul, additional, Steel, Peter A.D., additional, Steinkamp, Michele, additional, Weinberg, Roniel, additional, Wellman, David Stephenson, additional, Nader, Antoun, additional, Fitzgerald, Paul, additional, Ritz, Michaela, additional, Papp, Steven, additional, Bryson, Greg, additional, Craig, Alexandra, additional, Farhat, Cassandra, additional, Gammon, Braden, additional, Gofton, Wade, additional, Harris, Nicole, additional, Lalonde, Karl, additional, Liew, Allan, additional, Meulenkamp, Bradley, additional, Sonnenburg, Kendra, additional, Wai, Eugene, additional, Wilkin, Geoffrey, additional, Donegan, Derek, additional, Dinh, Cassandra, additional, Elkassabany, Nabil, additional, Horan, Annamarie, additional, Mehta, Samir, additional, Troxell, Karen, additional, Alderfer, Mary Ellen, additional, Brannen, Jason, additional, Cupitt, Christopher, additional, Gerhart, Stacy, additional, McLin, Renee, additional, Sheidy, Julie, additional, Yurick, Katherine, additional, Carson, Jeffrey, additional, Chen, Fei, additional, Dragert, Karen, additional, Kiss, Geza, additional, Malveaux, Halina, additional, McCloskey, Deborah, additional, Mellender, Scott, additional, Mungekar, Sagar S., additional, Noveck, Helaine, additional, Sagebien, Carlos, additional, Perlman, Barry, additional, Biby, Luat, additional, McKelvy, Gail, additional, Richards, Anna, additional, Azim, Syed, additional, Abola, Ramon, additional, Ayala, Brittney, additional, Halper, Darcy, additional, Mavarez, Ana, additional, Choi, Stephen, additional, Awad, Imad, additional, Flynn, Brendan, additional, Henry, Patrick, additional, Jenkinson, Richard, additional, Kaustov, Lilia, additional, Lappin, Elizabeth, additional, McHardy, Paul, additional, Singh, Amara, additional, Hauck, Ellen, additional, Donnelly, Joanne, additional, Gonzalez, Meera, additional, Haydel, Christopher, additional, Livelsberger, Jon, additional, Pazionis, Theresa, additional, Slattery, Bridget, additional, Vazquez-Trejo, Maritza, additional, Schwenk, Eric, additional, Baratta, Jaime, additional, Deiling, Brittany, additional, Deschamps, Laura, additional, Glick, Michael, additional, Katz, Daniel, additional, Krieg, James, additional, Lessin, Jennifer, additional, Torjman, Marc, additional, Chin, Ki Jinn, additional, Jin, Rongyu, additional, Salpeter, Mary Jane, additional, Powell, Mark, additional, Simmons, Jeffrey, additional, Lawson, Prentiss, additional, Kukreja, Promil, additional, Graves, Shanna, additional, Sturdivant, Adam, additional, Bryant, Ayesha, additional, Crump, Sandra Joyce, additional, Dillane, Derek, additional, Taylor, Michael, additional, Verrier, Michelle, additional, Applegate, Richard, additional, Arias, Ana, additional, Pineiro, Natasha, additional, Uppington, Jeffrey, additional, Wolinsky, Phillip, additional, Sappenfield, Joshua, additional, Gunnett, Amy, additional, Hagen, Jennifer, additional, Harris, Sara, additional, Hollen, Kevin, additional, Holloway, Brian, additional, Horodyski, Mary Beth, additional, Pogue, Trevor, additional, Ramani, Ramachandran, additional, Smith, Cameron, additional, Woods, Anna, additional, Warrick, Matthew, additional, Flynn, Kelly, additional, Mongan, Paul, additional, Ranganath, Yatish, additional, Fernholz, Sean, additional, Ingersoll-Weng, Esperanza, additional, Marian, Anil, additional, Seering, Melinda, additional, Sibenaller, Zita, additional, Stout, Lori, additional, Wagner, Allison, additional, Walter, Alicia, additional, Wong, Cynthia, additional, Magaziner, Jay, additional, Orwig, Denise, additional, Brown, Trina, additional, Dattilo, Jim, additional, Ellenberg, Susan, additional, Feng, Rui, additional, Fleisher, Lee, additional, Gaskins, Lakisha, additional, Goud, Maithri, additional, Helker, Chris, additional, Mezenghie, Lydia, additional, Montgomery, Brittany, additional, Preston, Peter, additional, Stephens, Alisa, additional, Schwartz, J. Sanford, additional, Tierney, Ann, additional, Weber, Ramona, additional, Chelly, Jacques, additional, Goel, Shiv, additional, Goncz, Wende, additional, Kawabe, Touichi, additional, Khetarpal, Sharad, additional, King, Kevin, additional, Kunkel, Frank, additional, Luke, Charles, additional, Monroe, Amy, additional, Shick, Vladislav, additional, Silipo, Anthony, additional, Stehle, Caroline, additional, Szabo, Katherine, additional, Yennam, Sudhakar, additional, Hoeft, Mark, additional, Breidenstein, Max, additional, Dominick, Timothy, additional, Friend, Alexander, additional, Mathews, Donald, additional, Lennertz, Richard, additional, Akere, Helen, additional, Balweg, Tyler, additional, Bo, Amber, additional, Doro, Christopher, additional, Goodspeed, David, additional, Lang, Gerald, additional, Parker, Maggie, additional, Rettammel, Amy, additional, Roth, Mary, additional, Sanders, Robert, additional, White, Marissa, additional, Whiting, Paul, additional, Allen, Brian, additional, Baker, Tracie, additional, Craven, Debra, additional, McEvoy, Matt, additional, Turnbo, Teresa, additional, Kates, Stephen, additional, Morgan, Melanie, additional, Willoughby, Teresa, additional, Weigel, Wade, additional, Auyong, David, additional, Fox, Ellie, additional, Welsh, Tina, additional, Cusson, Bruce, additional, Dobson, Sean, additional, Edwards, Christopher, additional, Harris, Lynette, additional, Henshaw, Daryl, additional, Johnson, Kathleen, additional, McKinney, Glen, additional, Miller, Scott, additional, Reynolds, Jon, additional, Turner, Jimmy, additional, VanEenenaam, David, additional, Weller, Robert, additional, Akhtar, Shamsuddin, additional, Blessing, Marcelle, additional, Johnson, Chanel, additional, Kampp, Michael, additional, Kunze, Kimberly, additional, Li, Jinlei, additional, O'Connor, Mary, additional, and Treggiari, Miriam, additional

Published
2021
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26. Aqueous nonelectrolyte solutions. Part XVI. Formula of deuterium sulfide D-hydrate and its dissociation thermodynamic functions

Author

Clarke, Collin W. and Glew, David N.

Subjects
Enthalpy -- Analysis, Clathrate compounds, Sulfides, Deuterium, Chemical equilibrium -- Analysis, Dissociation -- Analysis, Hydrogen, Solution (Chemistry), Chemical research -- Analysis
Abstract

A method has been devised to approximate both the hydrate formula number n and the standard thermodynamic functions for hydrate dissociation from the temperature change of the hydrate former fugacity along a univariant three-phase (h[l.sub.1.]g) equilibrium line. Thermodynamic equations are derived, their validity discussed, and an iterative method for their solution is described. The univariant (h[l.sub.1.]g) equilibrium dissociation of deuterium sulfide D-hydrate ([D.sub.2]S*n[D.sub.2]O phase h) into gaseous deuterium sulfide (g) and liquid deuterium oxide (l.sub.1) has been treated to give approximate formulae and dissociation constants at 58 temperatures from 2.798 to 30.666[degrees]C. Dissociation equilibrium constants Kp(h[right arrow] [l.sub.1]g) have been represented as a function of temperature by a four-parameter equation which yields both values and standard errors (i) for [DELTA] [H.sup.ot](h[right arrow][l.sub.1]g) and [DELTA][Cp.sup.ot](h[right arrow][l.sub.1]g) the standard enthalpy and heat capacity changes for D-hydrate dissociation and (ii) for n = r the approximate formula number of the D-hydrate at each experimental temperature. The formula [D.sub.2]S.6.115] [D.sub.2]O with standard error 0.018[D.sub.2]O is found for deuterium sulfide D-hydrate at lower quadruple point Q([hs.sub.1][l.sub.1]g) 3.392[degrees]C; an approximate formula [D.sub.2]S.5.840[D.sub.2]O with SE 0.019[D.sub.2]O is found at upper quadruple point Q([hs.sub.1][l.sub.2]g) 30.770 [degress]C. Key words: clathrate D-hydrate of deuterium sulfide, deuterium sulfide D- hydrate, formula of deuterium sulfide D-hydrate, thermodynamics of clathrate hydrate dissociation, dissociation equilibrium constant of deuterium sulfide D-hydrate, standard enthalpy, and heat capacity changes for dissociation of deuterium sulfide D-hydrate.

Published
2000

28. Standardization of Outpatient Procedure Narcotics: A Prospective Non-Inferiority Study to Reduce Opioid Use in Outpatient General Surgical Procedures

Author

Hartford, Luke, primary, Van Koughnett, Julie Ann M., additional, Murphy, Patrick, additional, Hilsden, Richard, additional, Gray, Daryl K., additional, Wigen, Robin B., additional, Gray, Samuel D., additional, Clarke, Collin, additional, Maciver, Allison H., additional, and Leslie, Ken, additional

Published
2018
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33. Emergency department discharge instructions comprehension and compliance study

Author

Clarke, Collin, Friedman, Steven Marc, Shi, Kevin, Arenovich, Tamara, Monzon, Jose, and Culligan, Christopher

Subjects
Patient education, Patient compliance
Abstract

Objectives: To assess patient comprehension of emergency department discharge instructions and to describe other predictors of patient compliance with discharge instructions. Methods: Patients departing from the emergency department of an [...]

Published
2005

40. Contributors

Author

Azari, Pari, Carlson, Jonathan D., Clarke, Collin F.M., Cornidez, Eric G., Field, Justin S., Hogan, Patrick W., Huh, Billy K., Kalfas, Iain H., Kuo, Chang Po, Lynch, Paul J., Makas, Christi, McJunkin, Tory L., Patil, Parag G., Pico, Tristan C., Pope, Jason E., Ranson, Matthew T., Srejic, Elizabeth, and Thompson, William C., IV

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41. Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery : A Randomized Clinical Trial.

Author

Neuman MD, Feng R, Ellenberg SS, Sieber F, Sessler DI, Magaziner J, Elkassabany N, Schwenk ES, Dillane D, Marcantonio ER, Menio D, Ayad S, Hassan M, Stone T, Papp S, Donegan D, Marshall M, Jaffe JD, Luke C, Sharma B, Azim S, Hymes R, Chin KJ, Sheppard R, Perlman B, Sappenfield J, Hauck E, Hoeft MA, Tierney A, Gaskins LJ, Horan AD, Brown T, Dattilo J, Carson JL, Looke T, Bent S, Franco-Mora A, Hedrick P, Newbern M, Tadros R, Pealer K, Vlassakov K, Buckley C, Gavin L, Gorbatov S, Gosnell J, Steen T, Vafai A, Zeballos J, Hruslinski J, Cardenas L, Berry A, Getchell J, Quercetti N, Bajracharya G, Billow D, Bloomfield M, Cuko E, Elyaderani MK, Hampton R, Honar H, Khoshknabi D, Kim D, Krahe D, Lew MM, Maheshwer CB, Niazi A, Saha P, Salih A, de Swart RJ, Volio A, Bolkus K, DeAngelis M, Dodson G, Gerritsen J, McEniry B, Mitrev L, Kwofie MK, Belliveau A, Bonazza F, Lloyd V, Panek I, Dabiri J, Chavez C, Craig J, Davidson T, Dietrichs C, Fleetwood C, Foley M, Getto C, Hailes S, Hermes S, Hooper A, Koener G, Kohls K, Law L, Lipp A, Losey A, Nelson W, Nieto M, Rogers P, Rutman S, Scales G, Sebastian B, Stanciu T, Lobel G, Giampiccolo M, Herman D, Kaufman M, Murphy B, Pau C, Puzio T, Veselsky M, Apostle K, Boyer D, Fan BC, Lee S, Lemke M, Merchant R, Moola F, Payne K, Perey B, Viskontas D, Poler M, D'Antonio P, O'Neill G, Abdullah A, Fish-Fuhrmann J, Giska M, Fidkowski C, Guthrie ST, Hakeos W, Hayes L, Hoegler J, Nowak K, Beck J, Cuff J, Gaski G, Haaser S, Holzman M, Malekzadeh AS, Ramsey L, Schulman J, Schwartzbach C, Azefor T, Davani A, Jaberi M, Masear C, Haider SB, Chungu C, Ebrahimi A, Fikry K, Marcantonio A, Shelvan A, Sanders D, Clarke C, Lawendy A, Schwartz G, Garg M, Kim J, Caruci J, Commeh E, Cuevas R, Cuff G, Franco L, Furgiuele D, Giuca M, Allman M, Barzideh O, Cossaro J, D'Arduini A, Farhi A, Gould J, Kafel J, Patel A, Peller A, Reshef H, Safur M, Toscano F, Tedore T, Akerman M, Brumberger E, Clark S, Friedlander R, Jegarl A, Lane J, Lyden JP, Mehta N, Murrell MT, Painter N, Ricci W, Sbrollini K, Sharma R, Steel PAD, Steinkamp M, Weinberg R, Wellman DS, Nader A, Fitzgerald P, Ritz M, Bryson G, Craig A, Farhat C, Gammon B, Gofton W, Harris N, Lalonde K, Liew A, Meulenkamp B, Sonnenburg K, Wai E, Wilkin G, Troxell K, Alderfer ME, Brannen J, Cupitt C, Gerhart S, McLin R, Sheidy J, Yurick K, Chen F, Dragert K, Kiss G, Malveaux H, McCloskey D, Mellender S, Mungekar SS, Noveck H, Sagebien C, Biby L, McKelvy G, Richards A, Abola R, Ayala B, Halper D, Mavarez A, Rizwan S, Choi S, Awad I, Flynn B, Henry P, Jenkinson R, Kaustov L, Lappin E, McHardy P, Singh A, Donnelly J, Gonzalez M, Haydel C, Livelsberger J, Pazionis T, Slattery B, Vazquez-Trejo M, Baratta J, Cirullo M, Deiling B, Deschamps L, Glick M, Katz D, Krieg J, Lessin J, Mojica J, Torjman M, Jin R, Salpeter MJ, Powell M, Simmons J, Lawson P, Kukreja P, Graves S, Sturdivant A, Bryant A, Crump SJ, Verrier M, Green J, Menon M, Applegate R, Arias A, Pineiro N, Uppington J, Wolinsky P, Gunnett A, Hagen J, Harris S, Hollen K, Holloway B, Horodyski MB, Pogue T, Ramani R, Smith C, Woods A, Warrick M, Flynn K, Mongan P, Ranganath Y, Fernholz S, Ingersoll-Weng E, Marian A, Seering M, Sibenaller Z, Stout L, Wagner A, Walter A, Wong C, Orwig D, Goud M, Helker C, Mezenghie L, Montgomery B, Preston P, Schwartz JS, Weber R, Fleisher LA, Mehta S, Stephens-Shields AJ, Dinh C, Chelly JE, Goel S, Goncz W, Kawabe T, Khetarpal S, Monroe A, Shick V, Breidenstein M, Dominick T, Friend A, Mathews D, Lennertz R, Sanders R, Akere H, Balweg T, Bo A, Doro C, Goodspeed D, Lang G, Parker M, Rettammel A, Roth M, White M, Whiting P, Allen BFS, Baker T, Craven D, McEvoy M, Turnbo T, Kates S, Morgan M, Willoughby T, Weigel W, Auyong D, Fox E, Welsh T, Cusson B, Dobson S, Edwards C, Harris L, Henshaw D, Johnson K, McKinney G, Miller S, Reynolds J, Segal BS, Turner J, VanEenenaam D, Weller R, Lei J, Treggiari M, Akhtar S, Blessing M, Johnson C, Kampp M, Kunze K, O'Connor M, Looke T, Tadros R, Vlassakov K, Cardenas L, Bolkus K, Mitrev L, Kwofie MK, Dabiri J, Lobel G, Poler M, Giska M, Sanders D, Schwartz G, Giuca M, Tedore T, Nader A, Bryson G, Troxell K, Kiss G, Choi S, Powell M, Applegate R, Warrick M, Ranganath Y, Chelly JE, Lennertz R, Sanders R, Allen BFS, Kates S, Weigel W, Li J, Wijeysundera DN, Kheterpal S, Moore RH, Smith AK, Tosi LL, Looke T, Mehta S, Fleisher L, Hruslinski J, Ramsey L, Langlois C, Mezenghie L, Montgomery B, Oduwole S, and Rose T

Subjects
Aged, Analgesics therapeutic use, Anesthesia, General adverse effects, Canada, Female, Humans, Male, Pain, Pain, Postoperative drug therapy, Patient Satisfaction, Anesthesia, Spinal adverse effects, Hip Fractures surgery
Abstract

Background: The REGAIN (Regional versus General Anesthesia for Promoting Independence after Hip Fracture) trial found similar ambulation and survival at 60 days with spinal versus general anesthesia for hip fracture surgery. Trial outcomes evaluating pain, prescription analgesic use, and patient satisfaction have not yet been reported., Objective: To compare pain, analgesic use, and satisfaction after hip fracture surgery with spinal versus general anesthesia., Design: Preplanned secondary analysis of a pragmatic randomized trial. (ClinicalTrials.gov: NCT02507505)., Setting: 46 U.S. and Canadian hospitals., Participants: Patients aged 50 years or older undergoing hip fracture surgery., Intervention: Spinal or general anesthesia., Measurements: Pain on postoperative days 1 through 3; 60-, 180-, and 365-day pain and prescription analgesic use; and satisfaction with care., Results: A total of 1600 patients were enrolled. The average age was 78 years, and 77% were women. A total of 73.5% (1050 of 1428) of patients reported severe pain during the first 24 hours after surgery. Worst pain over the first 24 hours after surgery was greater with spinal anesthesia (rated from 0 [no pain] to 10 [worst pain imaginable]; mean difference, 0.40 [95% CI, 0.12 to 0.68]). Pain did not differ across groups at other time points. Prescription analgesic use at 60 days occurred in 25% (141 of 563) and 18.8% (108 of 574) of patients assigned to spinal and general anesthesia, respectively (relative risk, 1.33 [CI, 1.06 to 1.65]). Satisfaction was similar across groups., Limitation: Missing outcome data and multiple outcomes assessed., Conclusion: Severe pain is common after hip fracture. Spinal anesthesia was associated with more pain in the first 24 hours after surgery and more prescription analgesic use at 60 days compared with general anesthesia., Primary Funding Source: Patient-Centered Outcomes Research Institute .

Published
2022
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42. Opioid-induced hyperalgesia: a review of epidemiology, mechanisms and management.

Author

Low Y, Clarke CF, and Huh BK

Subjects
Drug Tolerance, Humans, Hyperalgesia prevention & control, Pain Measurement, Analgesics, Opioid adverse effects, Hyperalgesia chemically induced
Abstract

There has been a growing interest in opioid-induced hyperalgesia (OIH), which is an increased sensitivity to pain caused by opioid exposure. Multiple underlying pathways may contribute to the development of OIH, and the mechanism may vary with the duration of opioid exposure, dose, type and route of administration. In addition, the distinction between OIH, tolerance and withdrawal should be made in both the basic and clinical science literature so as to help translate findings to the clinical phenomenon and to help determine the best strategies to prevent or treat OIH.

Published
2012

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