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638 results on '"Clarke, Blaise A."'

1. Clinical outcome and biomarker assessments of a multi-centre phase II trial assessing niraparib with or without dostarlimab in recurrent endometrial carcinoma

Author

Madariaga, Ainhoa, Garg, Swati, Tchrakian, Nairi, Dhani, Neesha C., Jimenez, Waldo, Welch, Stephen, MacKay, Helen, Ethier, Josee-Lyne, Gilbert, Lucy, Li, Xuan, Rodriguez, Angela, Chan, Lucy, Bowering, Valerie, Clarke, Blaise, Zhang, Tong, King, Ian, Downs, Gregory, Stockley, Tracy, Wang, Lisa, Udagani, Smitha, Oza, Amit M., and Lheureux, Stephanie

Published
2023
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2. Genomic characterization of DICER1-associated neoplasms uncovers molecular classes

Author

Kommoss, Felix K. F., Chong, Anne-Sophie, Chong, Anne-Laure, Pfaff, Elke, Jones, David T. W., Hiemcke-Jiwa, Laura S., Kester, Lennart A., Flucke, Uta, Gessler, Manfred, Schrimpf, Daniel, Sahm, Felix, Clarke, Blaise A., Stewart, Colin J. R., Wang, Yemin, Gilks, C. Blake, Kommoss, Friedrich, Huntsman, David G., Schüller, Ulrich, Koelsche, Christian, Glenn McCluggage, W., von Deimling, Andreas, and Foulkes, William D.

Published
2023
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3. Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire

Author

Millar, Douglas G., Yang, S. Y. Cindy, Sayad, Azin, Zhao, Qingchuan, Nguyen, Linh T., Warner, Kathrin, Sangster, Ami G., Nakatsugawa, Munehide, Murata, Kenji, Wang, Ben X., Shaw, Patricia, Clarke, Blaise, Bernardini, Marcus Q., Pugh, Trevor, Thibault, Pierre, Hirano, Naoto, Perreault, Claude, and Ohashi, Pamela S.

Published
2023
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6. Characterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors

Author

Chung, Douglas C., primary, Ghaedi, Maryam, additional, Warner, Kathrin, additional, Sayad, Azin, additional, Saibil, Samuel D., additional, Bernardini, Marcus Q., additional, Clarke, Blaise A., additional, Shaw, Patricia A., additional, Butler, Marcus O., additional, Easson, Alexandra, additional, Morrissy, Sorana, additional, Wang, Ben X., additional, Nguyen, Linh, additional, Ohashi, Pamela S., additional, and Jacquelot, Nicolas, additional

Published
2024
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7. Generation of an Inhibitory NK Cell Subset by TGF-β1/IL-15 Polarization

Author

Chung, Douglas C., primary, Garcia-Batres, Carlos R., additional, Millar, Douglas G., additional, Wong, Stephanie W. Y., additional, Elford, Alisha R., additional, Mathews, Jessica A., additional, Wang, Ben X., additional, Nguyen, Linh T., additional, Shaw, Patricia A., additional, Clarke, Blaise A., additional, Bernardini, Marcus Q., additional, Sacher, Adrian G., additional, Crome, Sarah Q., additional, and Ohashi, Pamela S., additional

Published
2024
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10. Transforming diagnostics: The implementation of digital pathology in clinical laboratories.

Author

Bruce, Christine, Prassas, Ioannis, Mokhtar, Mark, Clarke, Blaise, Youssef, Elaria, Wang, Catherine, and Yousef, George M

Subjects
PATHOLOGICAL laboratories, MEDICAL care research, CHANGE management
Abstract

Digital pathology (DP) has emerged as a cutting‐edge technology that promises to revolutionise diagnostics in clinical laboratories. This perspective article explores the implementation planning and considerations of DP in a single multicentre institution in Canada, the University Health Network, discussing benefits, challenges, potential implications and considerations for future adopters. We examine the transition from traditional microscopy to digital slide scanning and its impact on pathology practice, patient care and medical research. Furthermore, we address the regulatory, infrastructure and change management considerations for successful integration into clinical laboratories. By highlighting the advantages and addressing concerns, we aim to shed light on the transformative potential of DP and its role in shaping the future of diagnostics. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Understanding the clinical implication of mismatch repair deficiency in endometrioid endometrial cancer through a prospective study

Author

Kim, Soyoun Rachel, Tone, Alicia, Kim, Raymond H., Cesari, Matthew, Clarke, Blaise A., Eiriksson, Lua, Hart, Tae, Aronson, Melyssa, Holter, Spring, Lytwyn, Alice, Lajkosz, Katherine, Oldfield, Leslie, Gallinger, Steven, Bernardini, Marcus Q., Oza, Amit M., Djordjevic, Bojana, Lerner-Ellis, Jordan, Van de Laar, Emily, Vicus, Danielle, Pugh, Trevor, Pollett, Aaron, and Ferguson, Sarah E.

Published
2021
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14. A distinct innate lymphoid cell population regulates tumor-associated T cells

Author

Crome, Sarah Q, Nguyen, Linh T, Lopez-Verges, Sandra, Yang, SY Cindy, Martin, Bernard, Yam, Jennifer Y, Johnson, Dylan J, Nie, Jessica, Pniak, Michael, Yen, Pei Hua, Milea, Anca, Sowamber, Ramlogan, Katz, Sarah Rachel, Bernardini, Marcus Q, Clarke, Blaise A, Shaw, Patricia A, Lang, Philipp A, Berman, Hal K, Pugh, Trevor J, Lanier, Lewis L, and Ohashi, Pamela S

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Rare Diseases, Lymphoma, Hematology, Vaccine Related, Cancer, Immunization, Aetiology, 2.1 Biological and endogenous factors, CD3 Complex, CD56 Antigen, Cell Proliferation, Cytokines, Flow Cytometry, Humans, Immune Tolerance, Immunity, Innate, Immunotherapy, Interleukins, Killer Cells, Natural, Lymphocytes, Lymphocytes, Tumor-Infiltrating, Natural Cytotoxicity Triggering Receptor 1, Neoplasms, T-Lymphocytes, Tumor Microenvironment, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

Antitumor T cells are subject to multiple mechanisms of negative regulation. Recent findings that innate lymphoid cells (ILCs) regulate adaptive T cell responses led us to examine the regulatory potential of ILCs in the context of cancer. We identified a unique ILC population that inhibits tumor-infiltrating lymphocytes (TILs) from high-grade serous tumors, defined their suppressive capacity in vitro, and performed a comprehensive analysis of their phenotype. Notably, the presence of this CD56+CD3- population in TIL cultures was associated with reduced T cell numbers, and further functional studies demonstrated that this population suppressed TIL expansion and altered TIL cytokine production. Transcriptome analysis and phenotypic characterization determined that regulatory CD56+CD3- cells exhibit low cytotoxic activity, produce IL-22, and have an expression profile that overlaps with those of natural killer (NK) cells and other ILCs. NKp46 was highly expressed by these cells, and addition of anti-NKp46 antibodies to TIL cultures abrogated the ability of these regulatory ILCs to suppress T cell expansion. Notably, the presence of these regulatory ILCs in TIL cultures corresponded with a striking reduction in the time to disease recurrence. These studies demonstrate that a previously uncharacterized ILC population regulates the activity and expansion of tumor-associated T cells.

Published
2017

15. Brief family history questionnaire to screen for Lynch syndrome in women with newly diagnosed non-serous, non-mucinous ovarian cancers

Author

Kim, Soyoun Rachel, Tone, Alicia, Kim, Raymond, Cesari, Matthew, Clarke, Blaise, Hart, Tae, Aronson, Melyssa, Holter, Spring, Lytwyn, Alice, Maganti, Manjula, Oldfield, Leslie, Gallinger, Steven, Bernardini, Marcus Q, Oza, Amit M, Djordjevic, Bojana, Lerner-Ellis, Jordan, Van de Laar, Emily, Vicus, Danielle, Pugh, Trevor J, Pollett, Aaron, Ferguson, Sarah Elizabeth, and Eiriksson, Lua

Published
2022
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17. Computational pathology: an evolving concept.

Author

Prassas, Ioannis, Clarke, Blaise, Youssef, Timothy, Phlamon, Juliana, Dimitrakopoulos, Lampros, Rofaeil, Andrew, and Yousef, George M.

Abstract

The initial enthusiasm about computational pathology (CP) and artificial intelligence (AI) was that they will replace pathologists entirely on the way to fully automated diagnostics. It is becoming clear that currently this is not the immediate model to pursue. On top of the legal and regulatory complexities surrounding its implementation, the majority of tested machine learning (ML)-based predictive algorithms do not display the exquisite performance needed to render them unequivocal, standalone decision makers for matters with direct implications to human health. We are thus moving into a different model of “computer-assisted diagnostics”, where AI is there to provide support, rather than replacing, the pathologist. Herein we focus on the practical aspects of CP, from a pathologist perspective. There is a wide range of potential applications where CP can enhance precision of pathology diagnosis, tailor prognostic and predictive information, as well as save time. There are, however, a number of potential limitations for CP that currently hinder their wider adoption in the clinical setting. We address the key necessary steps towards clinical implementation of computational pathology, discuss the significant obstacles that hinders its adoption in the clinical context and summarize some proposed solutions. We conclude that the advancement of CP in the clinic is a promising resource-intensive endeavour that requires broad and inclusive collaborations between academia, industry, and regulatory bodies. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Current and new frontiers in hereditary cancer surveillance: Opportunities for liquid biopsy

Author

Farncombe, Kirsten M., primary, Wong, Derek, additional, Norman, Maia L., additional, Oldfield, Leslie E., additional, Sobotka, Julia A., additional, Basik, Mark, additional, Bombard, Yvonne, additional, Carile, Victoria, additional, Dawson, Lesa, additional, Foulkes, William D., additional, Malkin, David, additional, Karsan, Aly, additional, Parkin, Patricia, additional, Penney, Lynette S., additional, Pollett, Aaron, additional, Schrader, Kasmintan A., additional, Pugh, Trevor J., additional, Kim, Raymond H., additional, Aguilar-Mahecha, Adriana, additional, Aronson, Melyssa, additional, Baxter, Nancy N., additional, Bedard, Phil, additional, Berman, Hal, additional, Bernardini, Marcus Q., additional, Chan, Clarissa F., additional, Cil, Tulin, additional, Clarke, Blaise, additional, Dhalla, Irfan, additional, Elser, Christine, additional, Ene, Gabrielle EV., additional, Farncombe, Kirsten M., additional, Ferguson, Sarah, additional, Genge, Laura, additional, Gryfe, Robert, additional, Jacobson, Michelle R., additional, Kastner, Monika, additional, Kaurah, Pardeep, additional, Lafleur, Josiane, additional, Lerner-Ellis, Jordan, additional, Lheureux, Stephanie, additional, MacDonald, Shelley M., additional, McCuaig, Jeanna, additional, Mckee, Brian, additional, Mittmann, Nicole, additional, Panchal, Seema, additional, Piccinin, Carolyn, additional, Regier, Dean, additional, Rezoug, Zoulikha, additional, Rideout, Krista, additional, Semotiuk, Kara, additional, Singh, Sara, additional, Siu, Lillian, additional, Sun, Sophie, additional, Thain, Emily, additional, Wallace, Karin, additional, Ward, Thomas, additional, Westergard, Shelley, additional, Whittle, Stacy, additional, Xu, Wei, additional, and Yu, Celeste, additional

Published
2023
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21. Developing a prognostic micro-RNA signature for human cervical carcinoma.

Author

How, Christine, Pintilie, Melania, Bruce, Jeff P, Hui, Angela BY, Clarke, Blaise A, Wong, Philip, Yin, Shaoming, Yan, Rui, Waggott, Daryl, Boutros, Paul C, Fyles, Anthony, Hedley, David W, Hill, Richard P, Milosevic, Michael, and Liu, Fei-Fei

Subjects
Humans, MicroRNAs, Prognosis, Disease-Free Survival, Paraffin Embedding, Reproducibility of Results, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Adult, Aged, Aged, 80 and over, Middle Aged, Uterine Cervical Neoplasms, Female, Young Adult, and over, Gene Expression Regulation, Neoplastic, General Science & Technology
Abstract

Cervical cancer remains the third most frequently diagnosed and fourth leading cause of cancer death in women worldwide. We sought to develop a micro-RNA signature that was prognostic for disease-free survival, which could potentially allow tailoring of treatment for cervical cancer patients. A candidate prognostic 9-micro-RNA signature set was identified in the training set of 79 frozen specimens. However, three different approaches to validate this signature in an independent cohort of 87 patients with formalin-fixed paraffin-embedded (FFPE) specimens, were unsuccessful. There are several challenges and considerations associated with developing a prognostic micro-RNA signature for cervical cancer, namely: tumour heterogeneity, lack of concordance between frozen and FFPE specimens, and platform selection for global micro-RNA expression profiling in this disease. Our observations provide an important cautionary tale for future miRNA signature studies for cervical cancer, which can also be potentially applicable to miRNA profiling studies involving other types of human malignancies.

Published
2015

22. Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands

Author

Weinreb, Ilan, Piscuoglio, Salvatore, Martelotto, Luciano G, Waggott, Daryl, Ng, Charlotte KY, Perez-Ordonez, Bayardo, Harding, Nicholas J, Alfaro, Javier, Chu, Kenneth C, Viale, Agnes, Fusco, Nicola, da Cruz Paula, Arnaud, Marchio, Caterina, Sakr, Rita A, Lim, Raymond, Thompson, Lester DR, Chiosea, Simion I, Seethala, Raja R, Skalova, Alena, Stelow, Edward B, Fonseca, Isabel, Assaad, Adel, How, Christine, Wang, Jianxin, de Borja, Richard, Chan-Seng-Yue, Michelle, Howlett, Christopher J, Nichols, Anthony C, Wen, Y Hannah, Katabi, Nora, Buchner, Nicholas, Mullen, Laura, Kislinger, Thomas, Wouters, Bradly G, Liu, Fei-Fei, Norton, Larry, McPherson, John D, Rubin, Brian P, Clarke, Blaise A, Weigelt, Britta, Boutros, Paul C, and Reis-Filho, Jorge S

Subjects
Agricultural, Veterinary and Food Sciences, Biological Sciences, Bioinformatics and Computational Biology, Genetics, Agricultural Biotechnology, Cancer, Digestive Diseases, Adenocarcinoma, Amino Acid Sequence, Animals, Humans, Immunohistochemistry, Immunoprecipitation, Mice, Microscopy, Confocal, Models, Molecular, Molecular Sequence Data, Mutagenesis, Mutation, Missense, NIH 3T3 Cells, Protein Kinase C, Salivary Gland Neoplasms, Sequence Alignment, Sequence Analysis, DNA, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.

Published
2014

24. Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4

Author

Ramos, Pilar, Karnezis, Anthony N, Craig, David W, Sekulic, Aleksandar, Russell, Megan L, Hendricks, William PD, Corneveaux, Jason J, Barrett, Michael T, Shumansky, Karey, Yang, Yidong, Shah, Sohrab P, Prentice, Leah M, Marra, Marco A, Kiefer, Jeffrey, Zismann, Victoria L, McEachron, Troy A, Salhia, Bodour, Prat, Jaime, D'Angelo, Emanuela, Clarke, Blaise A, Pressey, Joseph G, Farley, John H, Anthony, Stephen P, Roden, Richard BS, Cunliffe, Heather E, Huntsman, David G, and Trent, Jeffrey M

Subjects
Cancer, Rare Diseases, Ovarian Cancer, Genetics, Base Sequence, Carcinoma, Small Cell, Chromatin Assembly and Disassembly, Chromosome Mapping, Computational Biology, DNA Helicases, DNA, Complementary, Electrophoresis, Polyacrylamide Gel, Exome, Female, Gene Library, Humans, Immunohistochemistry, Molecular Sequence Data, Mutation, Nuclear Proteins, Ovarian Neoplasms, Sequence Analysis, DNA, Transcription Factors, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Small cell carcinoma of the ovary of hypercalcemic type (SCCOHT) is an extremely rare, aggressive cancer affecting children and young women. We identified germline and somatic inactivating mutations in the SWI/SNF chromatin-remodeling gene SMARCA4 in 75% (9/12) of SCCOHT cases in addition to SMARCA4 protein loss in 82% (14/17) of SCCOHT tumors but in only 0.4% (2/485) of other primary ovarian tumors. These data implicate SMARCA4 in SCCOHT oncogenesis.

Published
2014

26. Uterine Clear Cell Carcinoma

Author

McConechy, Melissa K., Lee, Cheng-Han, Clarke, Blaise A., Cagle, Philip T., Series editor, Deavers, Michael T., editor, and Coffey, Donna M., editor

Published
2017
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29. MicroRNA-196b regulates the homeobox B7-vascular endothelial growth factor axis in cervical cancer.

Author

How, Christine, Hui, Angela BY, Alajez, Nehad M, Shi, Wei, Boutros, Paul C, Clarke, Blaise A, Yan, Rui, Pintilie, Melania, Fyles, Anthony, Hedley, David W, Hill, Richard P, Milosevic, Michael, and Liu, Fei-Fei

Subjects
Cell Line, Tumor, Humans, Carcinoma, Squamous Cell, Vascular Endothelial Growth Factor A, Homeodomain Proteins, MicroRNAs, RNA, Small Interfering, RNA, Messenger, Antineoplastic Agents, Survival Analysis, Signal Transduction, Cell Proliferation, Transcription, Genetic, Gene Expression Regulation, Neoplastic, Gamma Rays, Adult, Aged, Aged, 80 and over, Middle Aged, Uterine Cervical Neoplasms, Female, and over, Carcinoma, Squamous Cell, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, RNA, Messenger, Small Interfering, Transcription, Genetic, General Science & Technology
Abstract

The down-regulation of microRNA-196b (miR-196b) has been reported, but its contribution to cervical cancer progression remains to be investigated. In this study, we first demonstrated that miR-196b down-regulation was significantly associated with worse disease-free survival (DFS) for cervical cancer patients treated with combined chemo-radiation. Secondly, using a tri-modal approach for target identification, we determined that homeobox-B7 (HOXB7) was a bona fide target for miR-196b, and in turn, vascular endothelial growth factor (VEGF) was a downstream transcript regulated by HOXB7. Reconstitution of miR-196b expression by transient transfection resulted in reduced cell growth, clonogenicity, migration and invasion in vitro, as well as reduced tumor angiogenesis and tumor cell proliferation in vivo. Concordantly, siRNA knockdown of HOXB7 or VEGF phenocopied the biological effects of miR-196b over-expression. Our findings have demonstrated that the miR-196b/HOXB7/VEGF pathway plays an important role in cervical cancer progression; hence targeting this pathway could be a promising therapeutic strategy for the future management of this disease.

Published
2013

32. A novel population of CD103-expressing CD56 +regulatory ILCs suppresses intratumoural T cells and are associated with poor prognosis in patients with ovarian carcinoma

Author

Chung, Douglas, primary, Vakharia, Jehan, additional, Warner, Kathrin, additional, Jacquelot, Nicolas, additional, Sayad, Azin, additional, Han, SeongJun, additional, Ghaedi, Maryam, additional, Garcia-Batres, Carlos, additional, Elford, Alisha R, additional, Matthews, Jessica A, additional, Wang, Ben X, additional, Nguyen, Linh T, additional, Shaw, Patricia A, additional, Clarke, Blaise A, additional, Bernardini, Marcus Q, additional, Ferguson, Sarah E, additional, Crome, Sarah Q, additional, and Ohashi, Pamela S, additional

Published
2023
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33. Data from IL6 Induces an IL22+ CD8+ T-cell Subset with Potent Antitumor Function

Author

St. Paul, Michael, primary, Saibil, Samuel D., primary, Lien, Scott C., primary, Han, SeongJun, primary, Sayad, Azin, primary, Mulder, David T., primary, Garcia-Batres, Carlos R., primary, Elford, Alisha R., primary, Israni-Winger, Kavita, primary, Robert-Tissot, Céline, primary, Zon, Michael, primary, Katz, Sarah Rachel, primary, Shaw, Patricia A., primary, Clarke, Blaise A., primary, Bernardini, Marcus Q., primary, Nguyen, Linh T., primary, Haibe-Kains, Benjamin, primary, Pugh, Trevor J., primary, and Ohashi, Pamela S., primary

Published
2023
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34. Supplementary Figures and Tables from IL6 Induces an IL22+ CD8+ T-cell Subset with Potent Antitumor Function

Author

St. Paul, Michael, primary, Saibil, Samuel D., primary, Lien, Scott C., primary, Han, SeongJun, primary, Sayad, Azin, primary, Mulder, David T., primary, Garcia-Batres, Carlos R., primary, Elford, Alisha R., primary, Israni-Winger, Kavita, primary, Robert-Tissot, Céline, primary, Zon, Michael, primary, Katz, Sarah Rachel, primary, Shaw, Patricia A., primary, Clarke, Blaise A., primary, Bernardini, Marcus Q., primary, Nguyen, Linh T., primary, Haibe-Kains, Benjamin, primary, Pugh, Trevor J., primary, and Ohashi, Pamela S., primary

Published
2023
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35. NACT Supplementary Tables - revised from Neoadjuvant Chemotherapy of Ovarian Cancer Results in Three Patterns of Tumor-Infiltrating Lymphocyte Response with Distinct Implications for Immunotherapy

Author

Lo, Charlotte S., primary, Sanii, Sanaz, primary, Kroeger, David R., primary, Milne, Katy, primary, Talhouk, Aline, primary, Chiu, Derek S., primary, Rahimi, Kurosh, primary, Shaw, Patricia A., primary, Clarke, Blaise A., primary, and Nelson, Brad H., primary

Published
2023
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36. NACT Supplementary Figures - revised from Neoadjuvant Chemotherapy of Ovarian Cancer Results in Three Patterns of Tumor-Infiltrating Lymphocyte Response with Distinct Implications for Immunotherapy

Author

Lo, Charlotte S., primary, Sanii, Sanaz, primary, Kroeger, David R., primary, Milne, Katy, primary, Talhouk, Aline, primary, Chiu, Derek S., primary, Rahimi, Kurosh, primary, Shaw, Patricia A., primary, Clarke, Blaise A., primary, and Nelson, Brad H., primary

Published
2023
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37. Figure S6 from Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma

Author

Toker, Aras, primary, Nguyen, Linh T., primary, Stone, Simone C., primary, Yang, S.Y. Cindy, primary, Katz, Sarah Rachel, primary, Shaw, Patricia A., primary, Clarke, Blaise A., primary, Ghazarian, Danny, primary, Al-Habeeb, Ayman, primary, Easson, Alexandra, primary, Leong, Wey L., primary, McCready, David R., primary, Reedijk, Michael, primary, Guidos, Cynthia J., primary, Pugh, Trevor J., primary, Bernardini, Marcus Q., primary, and Ohashi, Pamela S., primary

Published
2023
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38. Supplementary Tables and Figures from Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3

Author

Mujcic, Hilda, primary, Nagelkerke, Anika, primary, Rouschop, Kasper M.A., primary, Chung, Stephen, primary, Chaudary, Naz, primary, Span, Paul N., primary, Clarke, Blaise, primary, Milosevic, Michael, primary, Sykes, Jenna, primary, Hill, Richard P., primary, Koritzinsky, Marianne, primary, and Wouters, Bradly G., primary

Published
2023
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39. Supplemental Figure legends from Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma

Author

Toker, Aras, primary, Nguyen, Linh T., primary, Stone, Simone C., primary, Yang, S.Y. Cindy, primary, Katz, Sarah Rachel, primary, Shaw, Patricia A., primary, Clarke, Blaise A., primary, Ghazarian, Danny, primary, Al-Habeeb, Ayman, primary, Easson, Alexandra, primary, Leong, Wey L., primary, McCready, David R., primary, Reedijk, Michael, primary, Guidos, Cynthia J., primary, Pugh, Trevor J., primary, Bernardini, Marcus Q., primary, and Ohashi, Pamela S., primary

Published
2023
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40. Supplementary Data from Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3

Author

Mujcic, Hilda, primary, Nagelkerke, Anika, primary, Rouschop, Kasper M.A., primary, Chung, Stephen, primary, Chaudary, Naz, primary, Span, Paul N., primary, Clarke, Blaise, primary, Milosevic, Michael, primary, Sykes, Jenna, primary, Hill, Richard P., primary, Koritzinsky, Marianne, primary, and Wouters, Bradly G., primary

Published
2023
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41. Supplemental Tables from Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma

Author

Toker, Aras, primary, Nguyen, Linh T., primary, Stone, Simone C., primary, Yang, S.Y. Cindy, primary, Katz, Sarah Rachel, primary, Shaw, Patricia A., primary, Clarke, Blaise A., primary, Ghazarian, Danny, primary, Al-Habeeb, Ayman, primary, Easson, Alexandra, primary, Leong, Wey L., primary, McCready, David R., primary, Reedijk, Michael, primary, Guidos, Cynthia J., primary, Pugh, Trevor J., primary, Bernardini, Marcus Q., primary, and Ohashi, Pamela S., primary

Published
2023
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42. Supplementary Figure 3 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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43. Supplementary Tables 1-4 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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44. Data from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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45. Supplementary Figure 1 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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46. Supplementary Figure 2 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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47. Supplementary Methods, Legends for Figures 1-5 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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48. Supplementary Figure 5 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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49. Supplementary Figure 4 from Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Author

Lou, Yuanmei, primary, McDonald, Paul C., primary, Oloumi, Arusha, primary, Chia, Stephen, primary, Ostlund, Christina, primary, Ahmadi, Ardalan, primary, Kyle, Alastair, primary, auf dem Keller, Ulrich, primary, Leung, Samuel, primary, Huntsman, David, primary, Clarke, Blaise, primary, Sutherland, Brent W., primary, Waterhouse, Dawn, primary, Bally, Marcel, primary, Roskelley, Calvin, primary, Overall, Christopher M., primary, Minchinton, Andrew, primary, Pacchiano, Fabio, primary, Carta, Fabrizio, primary, Scozzafava, Andrea, primary, Touisni, Nadia, primary, Winum, Jean-Yves, primary, Supuran, Claudiu T., primary, and Dedhar, Shoukat, primary

Published
2023
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