2,261 results on '"Clarke, B. A."'
Search Results
2. Opportunities to accelerate immunization progress in middle-income countries
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Zhu, Jason, Cole, Clarke B., Fihman, Johanna, Adjagba, Alex, Dasic, Mira, and Cernuschi, Tania
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- 2024
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3. Cost of finding and making vaccines
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Cole, Clarke B., primary, Evans, Beth, additional, and Scotney, Soleine, additional
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- 2023
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4. Front Matter
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Tredway, L. P., primary, Tomaso-Peterson, M., additional, Kerns, J. P., additional, and Clarke, B. B., additional
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- 2023
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5. PART II: Noninfectious Agents
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Tredway, L. P., primary, Tomaso-Peterson, M., additional, Kerns, J. P., additional, and Clarke, B. B., additional
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- 2023
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6. PART IV: Disease Diagnosis
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Tredway, L. P., primary, Tomaso-Peterson, M., additional, Kerns, J. P., additional, and Clarke, B. B., additional
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- 2023
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7. PART I: Infectious Diseases
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Tredway, L. P., primary, Tomaso-Peterson, M., additional, Kerns, J. P., additional, and Clarke, B. B., additional
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- 2023
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8. PART III: Disease Management
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Tredway, L. P., primary, Tomaso-Peterson, M., additional, Kerns, J. P., additional, and Clarke, B. B., additional
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- 2023
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9. Back Matter
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Tredway, L. P., primary, Tomaso-Peterson, M., additional, Kerns, J. P., additional, and Clarke, B. B., additional
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- 2023
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10. Introduction
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Tredway, L. P., primary, Tomaso-Peterson, M., additional, Kerns, J. P., additional, and Clarke, B. B., additional
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- 2023
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11. Updates from the International Consortium on Primary Graft Dysfunction: An Interim Report and Important Themes
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Truby, L.K., primary, Moayedi, Y., additional, Foroutan, F., additional, Han, J., additional, Henricksen, E., additional, Luikart, H., additional, Ródenas Alesina, E., additional, Guzman Bofarull, J., additional, Couto Mallon, D., additional, Moayedifar, R., additional, Takeda, K., additional, Kim, G., additional, Crespo-Leiro, M., additional, Felius, J., additional, Hall, S., additional, DeVore, A.D., additional, Lerman, J.B., additional, Sabatino, M., additional, Potena, L., additional, Rivas-Lasarte, M., additional, Segovia-Cubero, J., additional, Farrero Torres, M., additional, Tremblay-Gravel, M., additional, Noly, P., additional, Miller, R., additional, Chih, S., additional, Clarke, B., additional, Farr, M., additional, Fan, C., additional, Ross, H., additional, Khush, K., additional, and Zuckermann, A., additional
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- 2024
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12. Validation of a Machine Learning Primary Graft Dysfunction Risk Score in a Contemporary Heart Transplant Cohort: An Analysis of the International Consortium on PGD
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Moayedi, Y., primary, Truby, L., additional, Fan, C., additional, Foroutan, F., additional, Henricksen, E., additional, Luikart, H., additional, Ródenas Alesina, E., additional, Han, J., additional, Couto Mallon, D., additional, Guzman Bofarull, J., additional, Crespo-Leiro, M., additional, Moayedifar, R., additional, Kim, G., additional, Felius, J., additional, Sabatino, M., additional, Potena, L., additional, Lerman, M., additional, Takeda, K., additional, Tremblay-Gravel, M., additional, Noly, P., additional, Miller, R., additional, Zuckermann, A., additional, Clarke, B., additional, Rivas-Lasarte, M., additional, Hall, S., additional, Segovia-Cubero, J., additional, Farrero Torres, M., additional, Chih, S., additional, Devore, A., additional, Farr, M., additional, Ross, H., additional, and Khush, K., additional
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- 2024
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13. Surgical management of a vaginally placed mesh eroded into the urethra
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Clarke, B, primary, Davenport, A, additional, Shridhar, S, additional, and Gutman, R, additional
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- 2024
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14. Implementation, satisfaction, and attitudes towards fundamentals of laparoscopic surgery (FLS) for obstetrics and gynecology (OB/GYN) residencies in the united states
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Davenport, A, primary, Clarke, B, additional, and Hazen, N, additional
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- 2024
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15. Mitigating Risk by Using the Primary Graft Dysfunction-Artificial Intelligence (PGD-AI) Calculator in a Contemporary Toronto Cohort: An Analysis from The International Consortium on PGD
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Moayedi, Y., primary, Raslan, I., additional, Venkatraman, A., additional, Foroutan, F., additional, Truby, L., additional, Han, J., additional, Henricksen, E., additional, Guzman Bofarull, J., additional, Couto Mallon, D., additional, Moayedifar, R., additional, Luikart, H., additional, Kim, G., additional, Crespo-Leiro, M., additional, Felius, J., additional, Hall, S., additional, Devore, A., additional, Sabatino, M., additional, Potena, L., additional, Rivas-Lasarte, M., additional, Segovia-Cubero, J., additional, Farrero Torres, M., additional, Tremblay-Gravel, M., additional, Noly, P., additional, Miller, R., additional, Chih, S., additional, Zuckermann, A., additional, Clarke, B., additional, Khush, K., additional, Fan, C., additional, and Ross, H., additional
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- 2024
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16. Comparative Regional Analysis of Severe Primary Graft Dysfunction: Insights from Tthe International Consortium on PGD
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Ródenas Alesina, E., primary, Guzman Bofarull, J., additional, Moayedi, Y., additional, Truby, L., additional, Foroutan, F., additional, Fan, C., additional, Han, J., additional, Couto-Mallon, D., additional, Moayedifar, R., additional, Luikart, H., additional, Henricksen, E., additional, Kim, G., additional, Crespo-Leiro, M., additional, Hall, S., additional, Felius, J., additional, DeVore, A., additional, Takeda, K., additional, Lerman, J.B., additional, Sabatino, M., additional, Tremblay-Gravel, M., additional, Noly, P., additional, Ross, H., additional, Khush, K., additional, Miller, R., additional, Chih, S., additional, Clarke, B., additional, Zuckermann, A., additional, Segovia-Cubero, J., additional, Rivas-Lasarte, M., additional, and Farrero Torres, M., additional
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- 2024
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17. Apolipoprotein A-IV Amyloidosis Found Incidentally on an Explanted Heart in a Patient with Congenital Heart Disease
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Succar, C., primary, Toma, M., additional, Clarke, B., additional, Virani, S., additional, Bashir, J., additional, Cheung, A., additional, Lichtenstein, K., additional, Lai, C., additional, and Davis, M., additional
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- 2024
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18. Posterior Ischemic Optic Neuropathy After Heart Transplant
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Succar, C., primary, Hickman, S., additional, Chiu, W., additional, Toma, M., additional, Virani, S., additional, Clarke, B., additional, Davis, M., additional, Bashir, J., additional, Cheung, A., additional, and Lichtenstein, K., additional
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- 2024
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19. Intellectual property and access to medicines: mapping public attitudes toward pharmaceuticals during the United States-Mexico-Canada Agreement (USMCA) negotiation process
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Anna S. Y. Wong, Clarke B. Cole, and Jillian C. Kohler
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Transparency ,Accountability ,Pharmaceuticals ,Drug industry ,Government ,Access to medicines ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Transparency and accountability are essential components at all stages of the trade negotiation process. This study evaluates the extent to which these principles were upheld in the United States’ public consultation process during the negotiation of the United States-Mexico-Canada Agreement (USMCA), with respect to public comments about the pharmaceutical sector and access to medicines. Results The public consultation process occurred before the start of official negotiations and was overseen by the Office of the United States Trade Representative (USTR). It included both written comments and oral testimony about US trade negotiation objectives. Of the written comments that specifically discussed issues relating to pharmaceuticals, the majority were submitted by private individuals, members of the pharmaceutical industry, and civil society organizations. Nearly all comments submitted by non-industry groups indicated that access to medicines was a priority issue in the renegotiated agreement, with specific reference to price affordability. By contrast, more than 50% of submissions received from members or affiliates of the pharmaceutical industry advocated for strengthened pharmaceutical intellectual property rights, greater regulatory data protections, or both. This study reveals mixed outcomes with respect to the level of transparency achieved in the US trade negotiation process. Though input from the public at-large was actively solicited, the extent to which these comments were considered in the content of the final agreement is unclear. A preliminary comparison of the analyzed comments with the USTR’s final negotiating objectives and the final text of the USMCA shows that several provisions that were advanced exclusively by the pharmaceutical industry and ultimately adopted in the final agreement were opposed by the majority of non-industry stakeholders. Conclusions Negotiators could increase public transparency when choosing to advance one competing trade objective over another by actively providing the public with clear rationales for their negotiation positions, as well as details on how public comments are taken into account to form these rationales. Without greater clarity on these aspects, the public consultation process risks appearing to serve as a cursory government mechanism, lacking in accountability and undermining public trust in both the trade negotiation process and its outcomes.
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- 2021
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20. Data publication: The spatial association of accessory minerals with biotite in granitic rocks from the South Mountain Batholith, Nova Scotia, Canada
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(0000-0002-4687-899X) Clarke, B. D., (0000-0002-8289-1059) Renno, A., (0000-0002-7648-000X) Hamilton, D. C., (0000-0003-1113-2415) Gilbricht, S., (0000-0001-8904-6555) Bachmann, K., (0000-0002-4687-899X) Clarke, B. D., (0000-0002-8289-1059) Renno, A., (0000-0002-7648-000X) Hamilton, D. C., (0000-0003-1113-2415) Gilbricht, S., and (0000-0001-8904-6555) Bachmann, K.
- Abstract
Data publication: The spatial association of accessory minerals with biotite in granitic rocks from the South Mountain Batholith, Nova Scotia, Canada D. Barrie Clarke; Axel D. Renno; David C. Hamilton; Sabine Gilbricht; Kai Bachmann Related to publication Geosphere (2022) 18 (1): 1–18; https://doi.org/10.1130/GES02339.1 We use mineral liberation analysis (MLA) to quantify the spatial association of 15,118 grains of accessory apatite, monazite, xenotime, and zircon with essential biotite, and clustered with themselves, in a peraluminous biotite granodiorite from the South Mountain Batholith in Nova Scotia (Canada). A random distribution of accessory minerals demands that the proportion of accessory minerals in contact with biotite is identical to the proportion of biotite in the rock, and the binary touching factor (percentage of accessory mineral touching biotite divided by modal proportion of biotite) would be ~1.00. Instead, the mean binary touching factors for the four accessory minerals in relation to biotite are: apatite (5.06 for 11,168 grains), monazite (4.68 for 857 grains), xenotime (4.36 for 217 grains), and zircon (5.05 for 2876 grains). Shared perimeter factors give similar values. Accessory mineral grains that straddle biotite grain boundaries are larger than completely locked, or completely liberated, accessory grains. Only apatite-monazite clusters are significantly more abundant than expected for random distribution. The high, and statistically significant, binary touching factors and shared perimeter factors suggest a strong physical or chemical control on their spatial association. We evaluate random collisions in magma (synneusis), heterogeneous nucleation processes, induced nucleation in passively enriched boundary layers, and induced nucleation in actively enriched boundary layers to explain the significant touching factors. All processes operate during the crystalliz
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- 2024
21. Considering Frailty in SARS-CoV-2 Vaccine Development: How Geriatricians Can Assist
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Andrew MK, Schmader KE, Rockwood K, Clarke B, and McElhaney JE
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sars-cov-2 ,covid-19 ,vaccine ,frailty ,frail elderly ,geriatrics ,Geriatrics ,RC952-954.6 - Abstract
Melissa K Andrew,1,2 Kenneth E Schmader,3 Kenneth Rockwood,1 Barry Clarke,4 Janet E McElhaney5 1Department of Medicine, Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; 2Canadian Center for Vaccinology, Halifax, Nova Scotia, Canada; 3Division of Geriatrics, Duke University Medical Center and GRECC, Durham Veterans Affairs Medical Center, Durham, North Carolina, USA; 4Department of Family Medicine, Dalhousie University, Halifax, Canada; 5Health Sciences North Research Institute, Sudbury, Ontario, CanadaCorrespondence: Melissa K AndrewDepartment of Medicine, Division of Geriatric Medicine, Dalhousie University, Veterans Memorial Building, 5955, Veterans Memorial Lane, Halifax, NS, B3H 2E1, CanadaTel +1 902 473-4995Email mandrew@dal.caAbstract: The COVID-19 pandemic has disproportionately impacted frail older adults, especially residents of long-term care (LTC) facilities. This has appropriately led to prioritization of frail older adults and LTC residents, and those who care for them, in the vaccination effort against COVID-19. Older adults have distinct immunological, clinical, and practical complexity, which can be understood through a lens of frailty. Even so, frailty has not been considered in studies of COVID-19 vaccines to date, leading to concerns that the vaccines have not been optimally tailored for and evaluated in this population even as vaccination programs are being implemented. This is an example of how vaccines are often not tested in Phase 1/2/3 clinical trials in the people most in need of protection. We argue that geriatricians, as frailty specialists, have much to contribute to the development, testing and implementation of COVID-19 vaccines in older adults. We discuss roles for geriatricians in ten stages of the vaccine development process, covering vaccine design, trial design, trial recruitment, establishment and interpretation of illness definitions, safety monitoring, consideration of relevant health measures such as frailty and function, analysis methods to account for frailty and differential vulnerability, contributions in regulatory and advisory roles, post-marketing surveillance, and program implementation and public health messaging. In presenting key recommendations pertinent to each stage, we hope to contribute to a dialogue on how to push the field of vaccinology to embrace the complexity of frailty. Making vaccines that can benefit frail older adults will benefit everyone in the fight against COVID-19.Keywords: SARS-CoV-2, COVID-19, vaccine, frailty, frail elderly, geriatrics
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- 2021
22. Patient Perspectives on a Digital Mobile Health Application for RA
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Chahal S, Biln N, and Clarke B
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digital health application ,adoption ,willingness to pay ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Simran Chahal,1 Norma Biln,1 Bruce Clarke2 1Augurex Life Sciences Corp., Vancouver, British Columbia, Canada; 2B2 Consulting, Kelowna, British Columbia, CanadaCorrespondence: Simran ChahalAugurex Life Sciences, Suite 220 – 887, Great Northern Way, Vancouver, British Columbia, V5T 4T5, CanadaTel +1 604-637-3280Email schahal@augurex.comBackground: Emerging evidence suggests that patients are increasingly willing to use digital mobile health applications for rheumatoid arthritis (RA apps). The development and diffusion of RA apps open the possibility of improved management of the disease and better physician–patient interactions. However, adoption rates among apps have been lower than hoped, and research shows that many available RA apps lack key features. There is little research exploring patient preferences for RA apps or patients’ habits and preferences for app payment, which are likely key factors affecting adoption of this technology. This study seeks to understand characteristics of RA patients who have adopted RA apps, their preferences for app features, and their willingness to pay for, and experiences with app payment.Methods: Data for this study come from a 33-question online survey of patients with RA in Canada and the United States (N=30). Information on demographics, diagnosis and management of RA, current use and desired features of RA apps, and prior experience with and willingness to pay for an app was collected. Descriptive statistics are reported, and bivariate analyses (chi-square, point-biserial correlation, and ANOVA) were performed to understand relationships between variables.Results: Respondents showed a clear preference for certain app features, namely symptom tracking, scheduling appointments, and reminders. Physician recommendation for an app and patient tracking of symptoms with an app were significantly related to patient adoption of an RA app. Years since diagnosis with RA, physician recommendation for an RA app, and current use of a non-RA health tracking app were significantly related to patients’ willingness to pay a subscription for an RA app.Conclusion: RA patients appear to prefer task support features in an RA app, notably symptom tracking, appointment scheduling, and reminders, over other features such as those related to dialogue support and social support. The choice of whether an RA app will be free or based on a subscription, pay-per-service, or one-time purchase model may also play a role in eventual adoption. Similarly, physician recommendation appears to influence patients’ decision to use an RA app as well as their willingness to pay a subscription for an app.Keywords: digital health application, adoption, willingness to pay
- Published
- 2021
23. Combining phenotypic and genomic data to improve prediction of binary traits.
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Jarquin, D., Roy, A., Clarke, B., and Ghosal, S.
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PHENOTYPES ,CULTIVARS ,GENOTYPES ,PLANT breeders ,FORECASTING - Abstract
Plant breeders want to develop cultivars that outperform existing genotypes. Some characteristics (here 'main traits') of these cultivars are categorical and difficult to measure directly. It is important to predict the main trait of newly developed genotypes accurately. In addition to marker data, breeding programs often have information on secondary traits (or 'phenotypes') that are easy to measure. Our goal is to improve prediction of main traits with interpretable relations by combining the two data types using variable selection techniques. However, the genomic characteristics can overwhelm the set of secondary traits, so a standard technique may fail to select any phenotypic variables. We develop a new statistical technique that ensures appropriate representation from both the secondary traits and the genotypic variables for optimal prediction. When two data types (markers and secondary traits) are available, we achieve improved prediction of a binary trait by two steps that are designed to ensure that a significant intrinsic effect of a phenotype is incorporated in the relation before accounting for extra effects of genotypes. First, we sparsely regress the secondary traits on the markers and replace the secondary traits by their residuals to obtain the effects of phenotypic variables as adjusted by the genotypic variables. Then, we develop a sparse logistic classifier using the markers and residuals so that the adjusted phenotypes may be selected first to avoid being overwhelmed by the genotypic variables due to their numerical advantage. This classifier uses forward selection aided by a penalty term and can be computed effectively by a technique called the one-pass method. It compares favorably with other classifiers on simulated and real data. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Novel numerical method for parameterising fretting contacts
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Wade, A., Copley, R., Alsheikh Omar, A., Clarke, B., Liskiewicz, T., and Bryant, M.
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- 2020
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25. Real-time fretting loop regime transition identification using acoustic emissions
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Wade, A., Copley, R., Clarke, B., Alsheikh Omar, A., Beadling, A.R., Liskiewicz, T., and Bryant, M.G.
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- 2020
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26. Basal ganglia calcification in hypoparathyroidism and pseudohypoparathyroidism: local and systemic metabolic mechanisms
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Zavatta, G. and Clarke, B. L.
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- 2021
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27. Dual Arterial Access for Stenting of Aortic Coarctation in Patients with Near-Total Descending Aortic Interruption.
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Mahadevan, Vaikom, Hamid, T, Jamallulail, SI, Clarke, B, and Mahadevan, VS
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Endovascular stenting is a recognized treatment strategy for the treatment of coarctation of aorta (COA) in adults. The aortic coarctation is usually crossed retrogradely from the descending aorta via the femoral approach. We report three patients who had
- Published
- 2015
28. Intellectual property and access to medicines: mapping public attitudes toward pharmaceuticals during the United States-Mexico-Canada Agreement (USMCA) negotiation process
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Wong, Anna S. Y., Cole, Clarke B., and Kohler, Jillian C.
- Published
- 2021
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29. Pre-closure of Large-Sized Arterial Access Sites in Adults Undergoing Transcatheter Structural Interventions.
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Mahadevan, Vaikom, Hamid, T, Choudhury, TR, Clarke, B, and Mahadevan, VS
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INTRODUCTION: Patients undergoing structural heart interventions often require large-sized sheath insertion into femoral arteries and veins. Clinical outcome data on the use of suture-mediated devices for large femoral arterial access in structural heart i
- Published
- 2015
30. Impact of somatic molecular profiling on clinical trial outcomes in rare epithelial gynecologic cancer patients
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Rodriguez-Freixinos, V., Lheureux, S., Mandilaras, V., Clarke, B., Dhani, N.C., Mackay, H., Butler, M.O., Wang, L., Siu, L.L., Kamel-Reid, S., Stockley, T., Bedard, P.L., and Oza, A.M.
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- 2019
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31. Solar-like oscillations in red giants observed with \textit{Kepler}: influence of increased timespan on global oscillation parameters
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Hekker, S., Elsworth, Y., Mosser, B., Kallinger, T., Chaplin, W. J., De Ridder, J., Garcia, R. A., Stello, D., Clarke, B. D., Hall, J. R., and Ibrahim, K. A.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
The length of the asteroseismic timeseries obtained from the Kepler satellite analysed here span 19 months. Kepler provides the longest continuous timeseries currently available, which calls for a study of the influence of the increased timespan on the accuracy and precision of the obtained results. We find that in general a minimum of the order of 400 day long timeseries are necessary to obtain reliable results for the global oscillation parameters in more than 95% of the stars, but this does depend on
. In a statistical sense the quoted uncertainties seem to provide a reasonable indication of the precision of the obtained results in short (50-day) runs, they do however seem to be overestimated for results of longer runs. Furthermore, the different definitions of the global parameters used in the different methods have non-negligible effects on the obtained values. Additionally, we show that there is a correlation between nu_max and the flux variance. We conclude that longer timeseries improve the likelihood to detect oscillations with automated codes (from ~60% in 50 day runs to > 95% in 400 day runs with a slight method dependence) and the precision of the obtained global oscillation parameters. The trends suggest that the improvement will continue for even longer timeseries than the 600 days considered here, with a reduction in the median absolute deviation of more than a factor of 10 for an increase in timespan from 50 to 2000 days (the currently foreseen length of the mission). This work shows that global parameters determined with high precision - thus from long datasets - using different definitions can be used to identify the evolutionary state of the stars. (abstract truncated), Comment: 11 pages, 8 figures, accepted for publication by Astronomy and Astrophysics - Published
- 2012
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32. A pulsation zoo in the hot subdwarf B star KIC 10139564 observed by Kepler
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Baran, A. S., Reed, M. D., Stello, D., Ostensen, R. H., Telting, J. H., Pakstiene, E., O'Toole, S. J., Silvotti, R., Degroote, P., Bloemen, S., Hu, H., Van Grootel, V., Clarke, B. D., Van Cleve, J., Thompson, S. E., and Kawaler, S. D.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We present our analyses of 15 months of Kepler data on KIC 10139564. We detected 57 periodicities with a variety of properties not previously observed all together in one pulsating subdwarf B star. Ten of the periodicities were found in the low-frequency region, and we associate them with nonradial g-modes. The other periodicities were found in the high-frequency region, which are likely p-modes. We discovered that most of the periodicities are components of multiplets with a common spacing. Assuming that multiplets are caused by rotation, we derive a rotation period of 25.6(1.8) days. The multiplets also allow us to identify the pulsations to an unprecedented extent for this class of pulsator. We also detect l<=2 multiplets, which are sensitive to the pulsation inclination and can constrain limb darkening via geometric cancellation factors. While most periodicities are stable, we detected several regions that show complex patterns. Detailed analyses showed these regions are complicated by several factors. Two are combination frequencies that originate in the superNyquist region and were found to be reflected below the Nyquist frequency. The Fourier peaks are clear in the superNyquist region, but the orbital motion of Kepler smears the Nyquist frequency in the barycentric reference frame and this effect is passed on to the subNyquist reflections. Others are likely multiplets but unstable in amplitudes and/or frequencies. The density of periodicities also make KIC 10139564 challenging to explain using published models. This menagerie of properties should provide tight constraints on structural models, making this subdwarf B star the most promising for applying asteroseismology., Comment: 16 pages, 23 figures, MNRAS accepted
- Published
- 2012
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33. Oscillation mode linewidths of main-sequence and subgiant stars observed by Kepler
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Appourchaux, T., Benomar, O., Gruberbauer, M., Chaplin, W. J., Garcia, R. A., Handberg, R., Verner, G. A., Antia, H. M., Campante, T. L., Davies, G. R., Deheuvels, S., Hekker, S., Howe, R., Salabert, D., Bedding, T. R., White, T. R., Houdek, G., Aguirre, V. Silva, Elsworth, Y. P., Van Cleve, J., Clarke, B. D., Hall, J. R., and Kjeldsen, H.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Solar-like oscillations have been observed by {{\it Kepler}} and CoRoT in several solar-type stars. We study the variations of stellar p-mode linewidth as a function of effective temperature. Time series of 9 months of Kepler data have been used. The power spectra of 42 cool main-sequence stars and subgiants have been analysed using both Maximum Likelihood Estimators and Bayesian estimators, providing individual mode characteristics such as frequencies, linewidths and mode heights. Here we report on the mode linewidth at maximum power and at maximum mode height for these 42 stars as a function of effective temperature. We show that the mode linewidth at either maximum mode height or maximum amplitude follows a scaling relation with effective temperature, which is a combination of a power law plus a lower bound. The typical power law index is about 13 for the linewidth derived from the maximum mode height, and about 16 for the linewidth derived from the maximum amplitude while the lower bound is about 0.3 microHz and 0.7 microHz, respectively. We stress that this scaling relation is only valid for the cool main-sequence stars and subgiants, and does not have predictive power outside the temperature range of these stars., Comment: Accepted by A&A, 5 pages, 2 figures, 4 tables
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- 2011
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34. Seismic analysis of four solar-like stars observed during more than eight months by Kepler
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Mathur, S., Campante, T. L., Handberg, R., Garcia, R. A., Appourchaux, T., Bedding, T. R., Mosser, B., Chaplin, W. J., Ballot, J., Benomar, O., Bonanno, A., Corsaro, E., Gaulme, P., Hekker, S., Regulo, C., Salabert, D., Verner, G., White, T. R., Brandao, I. M., Creevey, O. L., Dogan, G., Bazot, M., Cunha, M. S., Elsworth, Y., Huber, D., Hale, S. J., Houdek, G., Karoff, C., Lundkvist, M., Metcalfe, T. S., Molenda-Zakowicz, J., Monteiro, M. J. P. F. G., Thompson, M. J., Stello, D., Christensen-Dalsgaard, J., Gilliland, R. L., Kawaler, S. D., Kjeldsen, H., Clarke, B. D., Girouard, F. R., Hall, J. R., Quintana, E. V., Sanderfer, D. T., and Seader, S. E.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Having started science operations in May 2009, the Kepler photometer has been able to provide exquisite data of solar-like stars. Five out of the 42 stars observed continuously during the survey phase show evidence of oscillations, even though they are rather faint (magnitudes from 10.5 to 12). In this paper, we present an overview of the results of the seismic analysis of 4 of these stars observed during more than eight months., Comment: 5 pages, 1 figure. To appear in the ASP proceedings of "The 61st Fujihara seminar: Progress in solar/stellar physics with helio- and asteroseismology", 13th-17th March 2011, Hakone, Japan
- Published
- 2011
35. The excitation of solar-like oscillations in a delta Scuti star by efficient envelope convection
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Antoci, V., Handler, G., Campante, T. L., Thygesen, A. O., Moya, A., Kallinger, T., Stello, D., Grigahcène, A., Kjeldsen, H., Bedding, T. R., Lüftinger, T., Christensen-Dalsgaard, J., Catanzaro, G., Frasca, A., De Cat, P., Uytterhoeven, K., Bruntt, H., Houdek, G., Kurtz, D. W., Lenz, P., Kaiser, A., Van Cleve, J., Allen, C., and Clarke, B. D.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Delta Scuti (delta Sct) stars are opacity-driven pulsators with masses of 1.5-2.5M$_{\odot}$, their pulsations resulting from the varying ionization of helium. In less massive stars such as the Sun, convection transports mass and energy through the outer 30 per cent of the star and excites a rich spectrum of resonant acoustic modes. Based on the solar example, with no firm theoretical basis, models predict that the convective envelope in delta Sct stars extends only about 1 per cent of the radius, but with sufficient energy to excite solar-like oscillations. This was not observed before the Kepler mission, so the presence of a convective envelope in the models has been questioned. Here we report the detection of solar-like oscillations in the delta Sct star HD 187547, implying that surface convection operates efficiently in stars about twice as massive as the Sun, as the ad hoc models predicted., Comment: to appear as a Letter to Nature
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- 2011
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36. Verification of the Kepler Input Catalog from Asteroseismology of Solar-type Stars
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Verner, G. A., Chaplin, W. J., Basu, S., Brown, T. M., Hekker, S., Huber, D., Karoff, C., Mathur, S., Metcalfe, T. S., Mosser, B., Quirion, P. -O., Appourchaux, T., Bedding, T. R., Bruntt, H., Campante, T. L., Elsworth, Y., García, R. A., Handberg, R., Régulo, C., Roxburgh, I. W., Stello, D., Christensen-Dalsgaard, J., Gilliland, R. L., Kawaler, S. D., Kjeldsen, H., Allen, C., Clarke, B. D., and Girouard, F. R.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We calculate precise stellar radii and surface gravities from the asteroseismic analysis of over 500 solar-type pulsating stars observed by the Kepler space telescope. These physical stellar properties are compared with those given in the Kepler Input Catalog (KIC), determined from ground-based multi-color photometry. For the stars in our sample, we find general agreement but we detect an average overestimation bias of 0.23 dex in the KIC determination of log (g) for stars with log (g)_KIC > 4.0 dex, and a resultant underestimation bias of up to 50% in the KIC radii estimates for stars with R_KIC < 2 R sun. Part of the difference may arise from selection bias in the asteroseismic sample; nevertheless, this result implies there may be fewer stars characterized in the KIC with R ~ 1 R sun than is suggested by the physical properties in the KIC. Furthermore, if the radius estimates are taken from the KIC for these affected stars and then used to calculate the size of transiting planets, a similar underestimation bias may be applied to the planetary radii., Comment: Published in The Astrophysical Journal Letters
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- 2011
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37. Asteroseismology from multi-month Kepler photometry: the evolved Sun-like stars KIC 10273246 and KIC 10920273
- Author
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Campante, T. L., Handberg, R., Mathur, S., Appourchaux, T., Bedding, T. R., Chaplin, W. J., García, R. A., Mosser, B., Benomar, O., Bonanno, A., Corsaro, E., Fletcher, S. T., Gaulme, P., Hekker, S., Karoff, C., Régulo, C., Salabert, D., Verner, G. A., White, T. R., Houdek, G., Brandão, I. M., Creevey, O. L., Doğan, G., Bazot, M., Christensen-Dalsgaard, J., Cunha, M. S., Elsworth, Y., Huber, D., Kjeldsen, H., Lundkvist, M., Molenda-Żakowicz, J., Monteiro, M. J. P. F. G., Stello, D., Clarke, B. D., Girouard, F. R., and Hall, J. R.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
The evolved main-sequence Sun-like stars KIC 10273246 (F-type) and KIC 10920273 (G-type) were observed with the NASA Kepler satellite for approximately ten months with a duty cycle in excess of 90%. Such continuous and long observations are unprecedented for solar-type stars other than the Sun. We aimed mainly at extracting estimates of p-mode frequencies - as well as of other individual mode parameters - from the power spectra of the light curves of both stars, thus providing scope for a full seismic characterization. The light curves were corrected for instrumental effects in a manner independent of the Kepler Science Pipeline. Estimation of individual mode parameters was based both on the maximization of the likelihood of a model describing the power spectrum and on a classic prewhitening method. Finally, we employed a procedure for selecting frequency lists to be used in stellar modeling. A total of 30 and 21 modes of degree l=0,1,2 - spanning at least eight radial orders - have been identified for KIC 10273246 and KIC 10920273, respectively. Two avoided crossings (l=1 ridge) have been identified for KIC 10273246, whereas one avoided crossing plus another likely one have been identified for KIC 10920273. Good agreement is found between observed and predicted mode amplitudes for the F-type star KIC 10273246, based on a revised scaling relation. Estimates are given of the rotational periods, the parameters describing stellar granulation and the global asteroseismic parameters $\Delta\nu$ and $\nu_{\rm{max}}$., Comment: 15 pages, 15 figures, to be published in Astronomy & Astrophysics
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- 2011
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38. Gravity Probe B: Final Results of a Space Experiment to Test General Relativity
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Everitt, C. W. F., DeBra, D. B., Parkinson, B. W., Turneaure, J. P., Conklin, J. W., Heifetz, M. I., Keiser, G. M., Silbergleit, A. S., Holmes, T., Kolodziejczak, J., Al-Meshari, M., Mester, J. C., Muhlfelder, B., Solomonik, V., Stahl, K., Worden, P., Bencze, W., Buchman, S., Clarke, B., Al-Jadaan, A., Al-Jibreen, H., Li, J., Lipa, J. A., Lockhart, J. M., Al-Suwaidan, B., Taber, M., and Wang, S.
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General Relativity and Quantum Cosmology - Abstract
Gravity Probe B, launched 20 April 2004, is a space experiment testing two fundamental predictions of Einstein's theory of General Relativity (GR), the geodetic and frame-dragging effects, by means of cryogenic gyroscopes in Earth orbit. Data collection started 28 August 2004 and ended 14 August 2005. Analysis of the data from all four gyroscopes results in a geodetic drift rate of -6,601.8+/- 18.3 mas/yr and a frame-dragging drift rate of -37.2 +/- 7.2 mas/yr, to be compared with the GR predictions of -6,606.1 mas/yr and -39.2 mas/yr, respectively (`mas' is milliarc-second; 1mas = 4.848 x 10-9 rad).
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- 2011
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39. Predicting the detectability of oscillations in solar-type stars observed by Kepler
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Chaplin, W. J., Kjeldsen, H., Bedding, T. R., Christensen-Dalsgaard, J., Gilliland, R. L., Kawaler, S. D., Appourchaux, T., Elsworth, Y., Garcia, R. A., Houdek, G., Karoff, C., Metcalfe, T. S., Molenda-Zakowicz, J., Monteiro, M. J. P. F. G., Thompson, M. J., Verner, G. A., Batalha, N., Borucki, W. J., Brown, T. M., Bryson, S. T., Christiansen, J. L., Clarke, B. D., Jenkins, J. M., Klaus, T. C., Koch, D., An, D., Ballot, J., Basu, S., Benomar, O., Bonanno, A., Broomhall, A. -M., Campante, T. L., Corsaro, E., Creevey, O. L., Esch, L., Gai, N., Gaulme, P., Hale, S. J., Handberg, R., Hekker, S., Huber, D., Mathur, S., Mosser, B., New, R., Pinsonneault, M. H., Pricopi, D., Quirion, P. -O., Regulo, C., Roxburgh, I. W., Salabert, D., Stello, D., and Suran, M. D.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Asteroseismology of solar-type stars has an important part to play in the exoplanet program of the NASA Kepler Mission. Precise and accurate inferences on the stellar properties that are made possible by the seismic data allow very tight constraints to be placed on the exoplanetary systems. Here, we outline how to make an estimate of the detectability of solar-like oscillations in any given Kepler target, using rough estimates of the temperature and radius, and the Kepler apparent magnitude., Comment: 21 pages, 6 figures, accepted for publication Astrophysical Journal
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- 2011
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40. Asteroseismology of red giants from the first four months of Kepler data: Global oscillation parameters for 800 stars
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Huber, D., Bedding, T. R., Stello, D., Mosser, B., Mathur, S., Kallinger, T., Hekker, S., Elsworth, Y. P., Buzasi, D. L., De Ridder, J., Gilliland, R. L., Kjeldsen, H., Chaplin, W. J., Garcia, R. A., Hale, S. J., Preston, H. L., White, T. R., Borucki, W. J., Christensen-Dalsgaard, J., Clarke, B. D., Jenkins, J. M., and Koch, D.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We have studied solar-like oscillations in ~800 red-giant stars using Kepler long-cadence photometry. The sample includes stars ranging in evolution from the lower part of the red-giant branch to the Helium main sequence. We investigate the relation between the large frequency separation (Delta nu) and the frequency of maximum power (nu_max) and show that it is different for red giants than for main-sequence stars, which is consistent with evolutionary models and scaling relations. The distributions of nu_max and Delta nu are in qualitative agreement with a simple stellar population model of the Kepler field, including the first evidence for a secondary clump population characterized by M ~> 2 M_sun and nu_max ~ 40-110 muHz. We measured the small frequency separations delta nu_02 and delta nu_01 in over 400 stars and delta nu_03 in over 40. We present C-D diagrams for l=1, 2 and 3 and show that the frequency separation ratios delta nu_02/Delta nu and delta nu_01/Delta nu have opposite trends as a function of Delta nu. The data show a narrowing of the l=1 ridge towards lower nu_max, in agreement with models predicting more efficient mode trapping in stars with higher luminosity. We investigate the offset epsilon in the asymptotic relation and find a clear correlation with Delta nu, demonstrating that it is related to fundamental stellar parameters. Finally, we present the first amplitude-nu_max relation for Kepler red giants. We observe a lack of low-amplitude stars for nu_max ~> 110 muHz and find that, for a given nu_max between 40-110 muHz, stars with lower Delta nu (and consequently higher mass) tend to show lower amplitudes than stars with higher Delta nu., Comment: 12 pages, 12 figures, accepted for publication in ApJ
- Published
- 2010
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41. Initial Characteristics of Kepler Short Cadence Data
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Gilliland, Ronald L., Jenkins, J. M., Borucki, W. J., Bryson, S. T., Caldwell, D. A., Clarke, B. D., Dotson, J. L., Haas, M. R., Hall, J., Klaus, T., Koch, D., McCauliff, S., Quintana, E. V., Twicken, J. D., and van Cleve, J. E.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
The Kepler Mission offers two options for observations -- either Long Cadence (LC) used for the bulk of core mission science, or Short Cadence (SC) which is used for applications such as asteroseismology of solar-like stars and transit timing measurements of exoplanets where the 1-minute sampling is critical. We discuss the characteristics of SC data obtained in the 33.5-day long Quarter 1 (Q1) observations with Kepler which completed on 15 June 2009. The truly excellent time series precisions are nearly Poisson limited at 11th magnitude providing per-point measurement errors of 200 parts-per-million per minute. For extremely saturated stars near 7th magnitude precisions of 40 ppm are reached, while for background limited measurements at 17th magnitude precisions of 7 mmag are maintained. We note the presence of two additive artifacts, one that generates regularly spaced peaks in frequency, and one that involves additive offsets in the time domain inversely proportional to stellar brightness. The difference between LC and SC sampling is illustrated for transit observations of TrES-2., Comment: 5 pages, 4 figures, ApJ Letters in press
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- 2009
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42. UNDERUTILIZATION OF INTRAVENOUS IRON IN A CONTEMPORARY POPULATION OF AMBULATORY HEART FAILURE PATIENTS IN CANADA
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Alajmi, F., primary, Kang, M., additional, Altamimi, A., additional, Clarke, B., additional, Davis, M., additional, Virani, S., additional, and Toma, M., additional
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- 2023
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43. 10282 Anatomical Considerations for Midurethral Sling and Hernias
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Clarke, B, primary, Shaprio, D, additional, and Sokol, A, additional
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- 2023
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44. Transparency and accountability in the negotiation of the US-Mexico-Canada trade agreement: the case of pharmaceuticals
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Anna S Y Wong, BSc, Clarke B Cole, MSc, and Jillian C Kohler, PhD
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Public aspects of medicine ,RA1-1270 - Abstract
Background: Transparency and accountability are essential components at all stages of the trade negotiation process. This study reports on the findings of an evaluation of the United States' public consultation process during the re-negotiation of the North American Free Trade Agreement (NAFTA)/United States-Mexico-Canada Agreement (USMCA) with respect to medicines and the pharmaceutical sector. Methods: A desk review was conducted to map the US negotiation rounds of the USMCA. Then, opportunities for the public to receive information and provide feedback about the proposed agreement provisions were identified. Finally, the written comments submitted by stakeholders during this public consultation process to the Federal Register (Regulations.gov) were queried and analysed using qualitative data analysis software NVivo for language related to pharmaceuticals and medicine. Findings: The public consultation process occurred before the start of official negotiations. It was overseen by the Office of the US Trade Representative (USTR) and included both written comments and oral testimony about US negotiation objectives. There were no further official opportunities for the public to engage with the negotiation process. Of the 1458 comments publicly available through the Federal Register, 75 specifically discussed issues related to pharmaceuticals for human use. More than 50% of submissions received from members or affiliates of the pharmaceutical industry advocated for strengthened pharmaceutical intellectual property rights, greater regulatory data protection, or both. Nearly all submissions from non-industry groups indicated that access to, or the affordability of, medicines was a priority issue area in the renegotiated agreement. Most submissions that directly discussed transparency and accountability were authored by industry groups and emphasised the importance of predictability and transparency in the areas of pharmaceutical intellectual property, regulatory affairs, pricing, and reimbursement to facilitate greater innovation. Interpretation: USMCA increased regulatory data protection for innovator drugs, increased the period of regulatory exclusivity for biologics, and granted patent term restoration provisions for regulatory delays, undermining public access to medicines. Although industry comments only constitute 26% of the comments submitted during the US public consultation period related to pharmaceuticals, they reflect the dominant position adopted in the USMCA. Funding: Connaught Fund Global Health Challenge Award.
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- 2021
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45. Closed form expressions for Bayesian sample size
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Clarke, B. and Yuan, Ao
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Mathematics - Statistics Theory ,62F15 (Primary) 62F12 (Secondary) - Abstract
Sample size criteria are often expressed in terms of the concentration of the posterior density, as controlled by some sort of error bound. Since this is done pre-experimentally, one can regard the posterior density as a function of the data. Thus, when a sample size criterion is formalized in terms of a functional of the posterior, its value is a random variable. Generally, such functionals have means under the true distribution. We give asymptotic expressions for the expected value, under a fixed parameter, for certain types of functionals of the posterior density in a Bayesian analysis. The generality of our treatment permits us to choose functionals that encapsulate a variety of inference criteria and large ranges of error bounds. Consequently, we get simple inequalities which can be solved to give minimal sample sizes needed for various estimation goals. In several parametric examples, we verify that our asymptotic bounds give good approximations to the expected values of the functionals they approximate. Also, our numerical computations suggest our treatment gives reasonable results., Comment: Published at http://dx.doi.org/10.1214/009053606000000308 in the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
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- 2006
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46. Prognostic Significance of Human Papilloma Virus and p16 Expression in Patients with Vulvar Squamous Cell Carcinoma who Received Radiotherapy
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Yap, M.L., Allo, G., Cuartero, J., Pintilie, M., Kamel-Reid, S., Murphy, J., Mackay, H., Clarke, B., Fyles, A., and Milosevic, M.
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- 2018
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47. Causality in medicine with particular reference to the viral causation of cancers
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Clarke, B.
- Subjects
616.99 - Abstract
In this thesis, I give a metascientific account of causality in medicine. I begin with two historical cases of causal discovery. These are the discovery of the causation of Burkitt's lymphoma by the Epstein-Barr virus, and of the various viral causes suggested for cervical cancer. These historical cases then support a philosophical discussion of causality in medicine. This begins with an introduction to the Russo-Williamson thesis (RWT), and discussion of a range of counter-arguments against it. Despite these, I argue that the RWT is historically workable, given a small number of modifications. I then expand Russo and Williamson's account. I first develop their suggestion that causal relationships in medicine require some kind of evidence of mechanism. I begin with a number of accounts of mechanisms and produce a range of consensus features of them. I then develop this consensus position by reference to the two historical case studies with an eye to their operational competence. In particular, I suggest that it is mechanistic models and their representations which we are concerned with in medicine, rather than the mechanism as it exists in the world. I then employ these mechanistic models to give an account of the sorts of evidence used in formulating and evaluating causal claims. Again, I use the two human viral oncogenesis cases to give this account. I characterise and distinguish evidence of mechanism from evidence of difference-making, and relate this to mechanistic models. I then suggest the relationship between types of evidence presents us with a means of tackling the reference-class problem. This sets the scene for the final chapter. Here, I suggest the manner in which these two different classes of evidence become integrated is also reflected in the way that developing research programmes change as their associated causal claims develop.
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- 2011
48. The digital world of early adolescents : a study of the use of digital technology to communicate emotionally
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Clarke, B. H.
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155 - Abstract
This dissemination examines the way 10-14 year olds are using digital technology, and in particular the way it is used to communicate emotionally. Little research exists on the way it might affect their wellbeing. The developmental stage of early adolescence and their psychosocial world is examined, and there is discussion of early adolescence as a time of transition. This study examines the social context within which early adolescents are using digital technology and looks in particular at the nature of their communication. It also looks at the psychological developmental processes that are at work as this age group engaged with media that many parents and teachers appear not to understand fully. The study was carried out over two years in the homes of 26 children aged 10-14, living in the south-east of England. The research included over 30 hours of filmed observation, diaries, friendship maps, individual interviews, friendship focus groups and an on-line bulletin board. The study concludes that while the mental processes that take place and the developmental stages have not changed, digital technology is being used to process some of the tasks of early adolescence, especially in identity formation, the importance and the influence of peers, and the way that emotional support is given and received. In playing with identity, building relationships, maintaining friendships and turning to each other for encouragement and companionship, children gain ‘digital agency. This process appears to be beneficial and is an important source of support and comfort to the early adolescent who is experiencing transition both cognitively, physically, and socially, through change of school. The study argues that there may be some who are at risk, and that it is likely that those children who are vulnerable in the off-line world are more likely to engage in risky behaviour when using digital technology.
- Published
- 2010
49. Cardiovascular, obstetric and neonatal outcomes in women with previous fontan repair
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Bonner, S.J., Asghar, O., Roberts, A., Vause, S., Clarke, B., and Keavney, B.
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- 2017
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50. Developing the latest framework to measure and incentivise pharmaceutical industry contributions to health research and development
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Clarke B. Cole, Stine Trolle, and Danny J. Edwards
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Research and development ,Medicine ,Access ,Methodology ,LMIC ,Incentive ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Major pharmaceutical companies contribute important expertise to health research and development (R&D), particularly in their ability to develop and bring pharmaceuticals to market. The Access to Medicine Index evaluates how 20 of the world’s largest pharmaceutical companies are directing R&D efforts towards the needs of people living in low- and middle-income countries. In dissemination of its findings, the Index stimulates pharmaceutical companies to expand R&D activities in this direction. The Index methodology is reviewed every 2 years, most recently for the 2018 Index, to ensure their R&D activity is benchmarked against current health R&D priorities as defined by the global health community. The review is based on consensus-building processes involving global health stakeholders. In the latest review, two main changes to the methodology were made that will further deepen the Index’s analysis of (1) how far companies’ R&D activity aligns with global health priorities; and (2) whether companies make plans to ensure resulting innovations reach populations in need globally. These changes will be applied in the 2018 Access to Medicine Index. Importantly, the methodology review process highlighted the need for further prioritisation from the global health community, in particular to emphasise to innovators which product innovations are needed most critically to address the burden of non-communicable diseases in low- and middle-income countries. Should such prioritisations be developed, the Index can play an important role in tracking and stimulating company contributions towards them.
- Published
- 2018
- Full Text
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