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19 results on '"Clark, Chantal C."'

3. Microlyse: a thrombolytic agent that targets VWF for clearance of microvascular thrombosis

Author

de Maat, Steven, Clark, Chantal C., Barendrecht, Arjan D., Smits, Simone, van Kleef, Nadine D., El Otmani, Hinde, Waning, Manon, van Moorsel, Marc, Szardenings, Michael, Delaroque, Nicolas, Vercruysse, Kristof, Urbanus, Rolf T., Sebastian, Silvie, Lenting, Peter J., Hagemeyer, Christoph, Renné, Thomas, Vanhoorelbeke, Karen, Tersteeg, Claudia, and Maas, Coen

Published
2022
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5. Targeted SERPIN (TaSER): a dual-action antithrombotic agent that targets platelets for SERPIN delivery

Author

CDL Contact activatie, CDL Research analisten, Poli Van Creveldkliniek Medisch, CDL Staf Research, Circulatory Health, Sanrattana, Wariya, Smits, Simone, Barendrecht, Arjan D, van Kleef, Nadine D, El Otmani, Hinde, Zivkovic, Minka, Roest, Mark, Renné, Thomas, Clark, Chantal C, de Maat, Steven, Maas, Coen, CDL Contact activatie, CDL Research analisten, Poli Van Creveldkliniek Medisch, CDL Staf Research, Circulatory Health, Sanrattana, Wariya, Smits, Simone, Barendrecht, Arjan D, van Kleef, Nadine D, El Otmani, Hinde, Zivkovic, Minka, Roest, Mark, Renné, Thomas, Clark, Chantal C, de Maat, Steven, and Maas, Coen

Published
2022

6. An increase in CD62L dim neutrophils precedes the development of pulmonary embolisms in COVID‐19 patients

Author

Spijkerman, Roy, Jorritsma, Nikita K. N., Bongers, Suzanne H., Bindels, Bas J. J., Jukema, Bernard N., Hesselink, Lillian, Hietbrink, Falco, Leenen, Luke P. H., Goor, Harriët M. R., Vrisekoop, Nienke, Kaasjager, Karin A. H., Koenderman, Leo, Stiphout, Feike, Nijdam, Thomas M. P., van de Ven, Nils L. M., Verhaegh, Remi, Spanjaard, Judith S., Verboeket, Benjamin W., Laane, Duco, van Wessem, Karlijn, van spengler, Daan E. J., Buitenwerf, Wiebe, Giustarini, Giulio, Mulder, Eva, Heijerman, Harry, Zabaleta, Amely Daza, van den bos, Frederique, Rademaker, Emma, Varkila, Meri R. J., de Mul, Nikki, Cremer, Olaf L., Slooter, Arjen, Delemarre, Eveline M., Nierkens, Stefan, Limper, Maarten, van Wijk, Femke, Pandit, Aridaman, Leavis, Helen, Clark, Chantal C., Barendrecht, Arjan D., Seinen, Cor W., Drost‐Verhoef, Sandra, Smits, Simone, Parr, Naomi M. J., Sebastian, Sylvie A. E., Koekman, Arnold C., van Wesel, Annet C., van der Vries, Erhard, Maas, Coen, de Maat, Steven, Haitjema, Saskia, and Hoefer, Imo E.

Subjects
Male, 0301 basic medicine, pulmonary embolism, Neutrophils, Receptor expression, SARS‐CoV‐2, Neutrophil Activation, law.invention, Cohort Studies, 0302 clinical medicine, Immunophenotyping, law, L‐selectin, L-Selectin, biology, Incidence (epidemiology), Regular Article, General Medicine, Middle Aged, Prognosis, Thrombosis, Intensive care unit, Pulmonary embolism, Intensive Care Units, Female, L-selectin, Disease Susceptibility, medicine.medical_specialty, Intensive Care Unit, Immunology, CD16, 03 medical and health sciences, COVID‐19, Internal medicine, medicine, CD62L, Humans, Aged, SARS-CoV-2, business.industry, COVID-19, medicine.disease, 030104 developmental biology, biology.protein, business, Biomarkers, Regular Articles, 030215 immunology
Abstract

Objectives A high incidence of pulmonary embolism (PE) is reported in patients with critical coronavirus disease 2019 (COVID‐19). Neutrophils may contribute to this through a process referred to as immunothrombosis. The aim of this study was to investigate the occurrence of neutrophil subpopulations in blood preceding the development of COVID‐19 associated PE. Methods We studied COVID‐19 patients admitted to the ICU of our tertiary hospital between 19‐03‐2020 and 17‐05‐2020. Point‐of‐care fully automated flow cytometry was performed prior to ICU admission, measuring the neutrophil activation/maturation markers CD10, CD11b, CD16 and CD62L. Neutrophil receptor expression was compared between patients who did or did not develop PE (as diagnosed on CT angiography) during or after their ICU stay. Results Among 25 eligible ICU patients, 22 subjects were included for analysis, of whom nine developed PE. The median (IQR) time between neutrophil phenotyping and PE occurrence was 9 (7‐12) days. A significant increase in the immune‐suppressive neutrophil phenotype CD16bright/CD62Ldim was observed on the day of ICU admission (P = 0.014) in patients developing PE compared to patients who did not. Conclusion The increase in this neutrophil phenotype indicates that the increased number of CD16bright/CD62Ldim neutrophils might be used as prognostic marker to predict those patients that will develop PE in critical COVID‐19 patients.

Published
2021

7. Thrombotic Events in COVID-19 Are Associated With a Lower Use of Prophylactic Anticoagulation Before Hospitalization and Followed by Decreases in Platelet Reactivity

Author

Clark, Chantal C., primary, Jukema, Bernard N., additional, Barendrecht, Arjan D., additional, Spanjaard, Judith S., additional, Jorritsma, Nikita K. N., additional, Smits, Simone, additional, de Maat, Steven, additional, Seinen, Cor W., additional, Verhoef, Sandra, additional, Parr, Naomi M. J., additional, Sebastian, Silvie A. E., additional, Koekman, Arnold C., additional, van Wesel, Annet C. W., additional, van Goor, Harriet M. R., additional, Spijkerman, Roy, additional, Bongers, Suzanne H., additional, van der Vries, Erhard, additional, Nierkens, Stefan, additional, Boes, Marianne, additional, Koenderman, Leo, additional, Kaasjager, Karin A. H., additional, and Maas, Coen, additional

Published
2021
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8. Detecting oral kallikrein-targeting therapy through triggered contact activation: A phase I study

Author

CDL KAM KC, CTI UDAIR, CDL Contact activatie, Circulatory Health, Infection & Immunity, CTI, CDL Staf Research, Hofman, Zonne L M, Clark, Chantal C, Hack, C Erik, de Maat, Steven, Maas, Coen, CDL KAM KC, CTI UDAIR, CDL Contact activatie, Circulatory Health, Infection & Immunity, CTI, CDL Staf Research, Hofman, Zonne L M, Clark, Chantal C, Hack, C Erik, de Maat, Steven, and Maas, Coen

Published
2020

9. A mutation in the kringle domain of human factor XII that causes autoinflammation, disturbs zymogen quiescence, and accelerates activation

Author

Circulatory Health, Infection & Immunity, CDL Contact activatie, CTI, CDL Staf Research, Hofman, Zonne L M, Clark, Chantal C, Sanrattana, Wariya, Nosairi, Aziz, Parr, Naomi M J, Živkovic, Minka, Krause, Karoline, Mahnke, Niklas A, Scheffel, Jörg, Hack, C Erik, Maurer, Marcus, de Maat, Steven, Maas, Coen, Circulatory Health, Infection & Immunity, CDL Contact activatie, CTI, CDL Staf Research, Hofman, Zonne L M, Clark, Chantal C, Sanrattana, Wariya, Nosairi, Aziz, Parr, Naomi M J, Živkovic, Minka, Krause, Karoline, Mahnke, Niklas A, Scheffel, Jörg, Hack, C Erik, Maurer, Marcus, de Maat, Steven, and Maas, Coen

Published
2020

10. Truncation of ADAMTS13 by Plasmin Enhances Its Activity in Plasma

Author

Clark, Chantal C., Mebius, Mirjam M., de Maat, Steven, Tielens, Aloysius G.M., de Groot, Philip G, Urbanus, Rolf T, Fijnheer, Rob, Hazenberg, Bouke P.C., Van Hellemond, Jaap J., Maas, Coen, Afd Chemical Biology and Drug Discovery, LS Veterinaire biochemie, Dep Biochemie en Celbiologie, Medical Microbiology & Infectious Diseases, Translational Immunology Groningen (TRIGR), Afd Chemical Biology and Drug Discovery, LS Veterinaire biochemie, and Dep Biochemie en Celbiologie

Subjects
0301 basic medicine, Protein Denaturation, Protein Folding, Plasmin, VON-WILLEBRAND-FACTOR, medicine.medical_treatment, Amino Acid Motifs, Immunoblotting, ADAMTS13 Protein, Plasma protein binding, 030204 cardiovascular system & hematology, THROMBIN, ACTIVATION, 03 medical and health sciences, 0302 clinical medicine, Thrombin, Protein Domains, Von Willebrand factor, hemic and lymphatic diseases, Fibrinolysis, BINDING, medicine, Disintegrin, Humans, Fibrinolysin, plasmin, Thrombospondin, Binding Sites, biology, Chemistry, Amyloidosis, Hematology, ADAMTS13, Recombinant Proteins, Cell biology, von willebrand factor, 030104 developmental biology, biology.protein, INACTIVATION, Peptides, Protein Binding, medicine.drug, circulatory and respiratory physiology
Abstract

ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) cleaves von Willebrand Factor (VWF) multimers to control their thrombogenicity. The fibrinolytic enzyme plasmin can cleave VWF in a similar manner. However, plasmin can also cleave ADAMTS13, which ultimately inactivates it. This leaves the overall role of plasmin in primary haemostasis uncertain.We investigated the combined molecular effects of plasmin on VWF and ADAMTS13. We first identified that plasmin destroys FRETS-VWF73 substrate by cleaving the ADAMTS13 binding region in a buffered system. We next investigated how plasmin affects both VWF and ADAMTS13 under static conditions in plasma by western blotting. We found that globular VWF is largely protected from plasmin cleavage. However, ADAMTS13 is rapidly cleaved under these conditions, suggesting inactivation. Surprisingly, we observed that plasmin enhances ADAMTS13 activity in a modified two-stage FRETS-VWF73 assay that protects FRETS-VWF73 substrate from degradation. In direct binding studies under the same conditions, we found that plasmin generates multiple C-terminally truncated forms of ADAMTS13 with VWF-binding capacity. In an effort to seek evidence for this mechanism in vivo, we analysed plasma from patients with systemic amyloidosis, which is hallmarked by a hyperfibrinolytic state. We found that their plasma contained increased levels of C-terminally truncated forms of ADAMTS13, which correlated with their hyperfibrinolytic state.We propose that truncation of ADAMTS13 by plasmin abolishes intramolecular self-association, which improves interaction with unfolded VWF.

Published
2018

13. A mutation in the kringle domain of human factor XII that causes autoinflammation, disturbs zymogen quiescence, and accelerates activation

Author

Hofman, Zonne L.M., primary, Clark, Chantal C., additional, Sanrattana, Wariya, additional, Nosairi, Aziz, additional, Parr, Naomi M.J., additional, Živkovic, Minka, additional, Krause, Karoline, additional, Mahnke, Niklas A., additional, Scheffel, Jörg, additional, Hack, C. Erik, additional, Maurer, Marcus, additional, de Maat, Steven, additional, and Maas, Coen, additional

Published
2020
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15. Heparin Forms Polymers with Cell-free DNA Which Elongate Under Shear in Flowing Blood

Author

MS Nefrologie, CDL Research analisten, CDL Contact activatie, Poli Van Creveldkliniek Medisch, Circulatory Health, CTI Leusen, CDL Staf Research, de Vries, Joost C, Barendrecht, Arjan D, Clark, Chantal C, Urbanus, Rolf T, Boross, Peter, de Maat, Steven, Maas, Coen, MS Nefrologie, CDL Research analisten, CDL Contact activatie, Poli Van Creveldkliniek Medisch, Circulatory Health, CTI Leusen, CDL Staf Research, de Vries, Joost C, Barendrecht, Arjan D, Clark, Chantal C, Urbanus, Rolf T, Boross, Peter, de Maat, Steven, and Maas, Coen

Published
2019

16. Truncation of ADAMTS13 by Plasmin Enhances Its Activity in Plasma

Author

Clark, Chantal C, Mebius, Mirjam M, de Maat, Steven, Tielens, Aloysius G M, de Groot, Philip G, Urbanus, Rolf T, Fijnheer, Rob, Hazenberg, Bouke P C, van Hellemond, Jaap J, Maas, Coen, Clark, Chantal C, Mebius, Mirjam M, de Maat, Steven, Tielens, Aloysius G M, de Groot, Philip G, Urbanus, Rolf T, Fijnheer, Rob, Hazenberg, Bouke P C, van Hellemond, Jaap J, and Maas, Coen

Published
2018

17. Truncation of ADAMTS13 by Plasmin Enhances Its Activity in Plasma

Author

Afd Chemical Biology and Drug Discovery, LS Veterinaire biochemie, Dep Biochemie en Celbiologie, Clark, Chantal C., Mebius, Mirjam M., de Maat, Steven, Tielens, Aloysius G.M., de Groot, Philip G, Urbanus, Rolf T, Fijnheer, Rob, Hazenberg, Bouke P.C., Van Hellemond, Jaap J., Maas, Coen, Afd Chemical Biology and Drug Discovery, LS Veterinaire biochemie, Dep Biochemie en Celbiologie, Clark, Chantal C., Mebius, Mirjam M., de Maat, Steven, Tielens, Aloysius G.M., de Groot, Philip G, Urbanus, Rolf T, Fijnheer, Rob, Hazenberg, Bouke P.C., Van Hellemond, Jaap J., and Maas, Coen

Published
2018

18. Truncation of ADAMTS13 by Plasmin Enhances Its Activity in Plasma

Author

CDL Contact activatie, Circulatory Health, CDL Cluster Onderzoek en Onderwijs, CDL Staf Research, Clark, Chantal C, Mebius, Mirjam M, de Maat, Steven, Tielens, Aloysius G M, de Groot, Philip G, Urbanus, Rolf T, Fijnheer, Rob, Hazenberg, Bouke P C, van Hellemond, Jaap J, Maas, Coen, CDL Contact activatie, Circulatory Health, CDL Cluster Onderzoek en Onderwijs, CDL Staf Research, Clark, Chantal C, Mebius, Mirjam M, de Maat, Steven, Tielens, Aloysius G M, de Groot, Philip G, Urbanus, Rolf T, Fijnheer, Rob, Hazenberg, Bouke P C, van Hellemond, Jaap J, and Maas, Coen

Published
2018

19. FXII contact activation is dependent on binding through two unique patches in its EGF-1 domain and can be prevented by (VHH) targeting.

Author

Frunt, Rowan, El Otmani, Hinde, Smits, Simone, Clark, Chantal C., and Maas, Coen

Abstract

Factor XII (FXII) triggers contact activation by binding to foreign surfaces, with the EGF-1 domain being the primary binding site. Blocking FXII surface-binding might hold therapeutic value to prevent medical device-induced thrombosis.

Published
2024
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