19 results on '"Clara Williams"'
Search Results
2. Interference between ER stress-related bZIP-type and jasmonate-inducible bHLH-type transcription factors in the regulation of triterpene saponin biosynthesis in Medicago truncatula
- Author
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Bianca Ribeiro, Marie-Laure Erffelinck, Elia Lacchini, Evi Ceulemans, Maite Colinas, Clara Williams, Evelien Van Hamme, Rebecca De Clercq, Maria Perassolo, and Alain Goossens
- Subjects
triterpene ,saponin ,Medicago catharanthus ,catharanthus ,jasmonate ,endoplasmic reticulum ,Plant culture ,SB1-1110 - Abstract
Triterpene saponins (TS) are a structurally diverse group of metabolites that are widely distributed in plants. They primarily serve as defense compounds and their production is often triggered by biotic stresses through signaling cascades that are modulated by phytohormones such as the jasmonates (JA). Two JA-modulated basic helix-loop-helix (bHLH) transcription factors (TFs), triterpene saponin biosynthesis activating regulator 1 (TSAR1) and TSAR2, have previously been identified as direct activators of TS biosynthesis in the model legume Medicago truncatula. Here, we report on the involvement of the core endoplasmic reticulum (ER) stress-related basic leucine zipper (bZIP) TFs bZIP17 and bZIP60 in the regulation of TS biosynthesis. Expression and processing of M. truncatula bZIP17 and bZIP60 proteins were altered in roots with perturbed TS biosynthesis or treated with JA. Accordingly, such roots displayed an altered ER network structure. M. truncatula bZIP17 and bZIP60 proteins were shown to localize in the nucleus and appeared to be capable of interfering with the TSAR-mediated transactivation of TS biosynthesis genes. Furthermore, interference between ER stress-related bZIP and JA-modulated bHLH TFs in the regulation of JA-dependent terpene biosynthetic pathways may be widespread in the plant kingdom, as we demonstrate that it also occurs in the regulation of monoterpene indole alkaloid biosynthesis in the medicinal plant Catharanthus roseus.
- Published
- 2022
- Full Text
- View/download PDF
3. LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples
- Author
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Elizabeth C. Stahl, Allan R. Gopez, Connor A. Tsuchida, Vinson B. Fan, Erica A. Moehle, Lea B. Witkowsky, Jennifer R. Hamilton, Enrique Lin-Shiao, Matthew McElroy, Shana L. McDevitt, Alison Ciling, C. Kimberly Tsui, Kathleen Pestal, Holly K. Gildea, Amanda Keller, Iman A. Sylvain, Clara Williams, Ariana Hirsh, Alexander J. Ehrenberg, Rose Kantor, Matthew Metzger, Kara L. Nelson, Fyodor D. Urnov, Bradley R. Ringeisen, Petros Giannikopoulos, Jennifer A. Doudna, and IGI Testing Consortium
- Subjects
Medicine ,Science - Abstract
Clinical and surveillance testing for the SARS-CoV-2 virus relies overwhelmingly on RT-qPCR-based diagnostics, yet several popular assays require 2–3 separate reactions or rely on detection of a single viral target, which adds significant time, cost, and risk of false-negative results. Furthermore, multiplexed RT-qPCR tests that detect at least two SARS-CoV-2 genes in a single reaction are typically not affordable for large scale clinical surveillance or adaptable to multiple PCR machines and plate layouts. We developed a RT-qPCR assay using the Luna Probe Universal One-Step RT-qPCR master mix with publicly available primers and probes to detect SARS-CoV-2 N gene, E gene, and human RNase P (LuNER) to address these shortcomings and meet the testing demands of a university campus and the local community. This cost-effective test is compatible with BioRad or Applied Biosystems qPCR machines, in 96 and 384-well formats, with or without sample pooling, and has a detection sensitivity suitable for both clinical reporting and wastewater surveillance efforts.
- Published
- 2021
4. Competing Preferent Community Prospecting Rights: A Nonchalant Custodian?
- Author
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Nic Olivier, Clara Williams, and Pieter Badenhorst
- Subjects
Mineral resources ,prospecting rights ,traditional communities ,Law in general. Comparative and uniform law. Jurisprudence ,K1-7720 - Abstract
Traditional communities that were precluded from the benefits and financial rewards of exploitation of the mineral resources of South Africa are afforded the opportunity to lodge an application with the Department of Mineral Resources (hereafter the department) to obtain a so-called preferent prospecting right (or mining right) in respect of land which is registered - or to be registered - in their name. An applicant on behalf of the community has to meet the requirements of section 104(2) of the Mineral and Petroleum Resources Development Act 28 of 2002 (hereafter the MPRDA). This in line with one of the objectives of the MPRDA of expanding the opportunities for historically disadvantaged persons, such as traditional communities, to enter into, and actively participate in, the mineral industry and to benefit from the exploitation of the nation's mineral resources (s 2(d)). The Minister of Mineral Resources ((hereafter the minister), in his/her capacity as the custodian of the mineral resources of South Africa on behalf of the people of South Africa (s 3(1)), is, amongst others, by implication tasked with achieving, these objectives. The same applies to the department and its officials. However, this was unfortunately not the experience of a traditional community, the Bengwenyama-Ya-Maswazi community (hereafter the BYM community), who had to battle through two rounds of litigation with the minister, the department and persons and entities which promoted their own interests whilst attempting to convey the (false) impression that they were representing the community. The subject of this discussion is the second round of litigation between the Bengwenyama-Ya-Maswazi Tribal Council and Genorah. The second round of litigation involved competing applications for preferent community prospecting rights in two related appeals heard together by the Supreme Court of Appeal (hereafter the SCA). The first appeal concerned preferent community prospecting rights on the farm Nooitverwacht (hereafter the Nooitverwacht appeal) and the second appeal involved preferent community prospecting rights on the farm Eerstegeluk (hereafter the Eerstegeluk appeal). The focus of the discussion is on the Nooitverwacht appeal, and references (where appropriate) will be made to the Eerstegeluk appeal. A number of related issues are also discussed – these include the distinction between prospecting rights and preferent community prospecting rights; the meaning of "... land which is registered or to be registered in the name of the community concerned" (with reference to restitution land, redistribution land, and community land acquired from own resources); and the changing legal landscape relating to community decision-making and consultation.
- Published
- 2017
- Full Text
- View/download PDF
5. MACCSAND (Pty) Ltd v CITY OF CAPE TOWN 2012 (4) SA 181 (CC)
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Nic Olivier, Clara Williams, and Pieter Badenhorst
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co-operative government ,conflict of laws ,intergovernmental relations ,Land Use Planning Ordinance 15 of 1985 ,land use ,Mineral and Petroleum Resources Development Act 28 of 2002 ,mining ,planning ,rezoning ,Law in general. Comparative and uniform law. Jurisprudence ,K1-7720 - Abstract
The Constitutional Court in Maccsand (Pty) Ltd v City of Cape Town (CCT 103/11) 2012 ZACC 7 decided that the granting of mining rights or mining permits by the Minister of Mineral Resources in terms of the Mineral and Petroleum Resources Development Act 28 of 2002 does not obviate the obligation on an applicant to obtain authorisations in terms of other legislation that deals with functional domains other than minerals, mining and prospecting. This applies to all other legislation, irrespective of whether the responsible administrator of such other legislation is in the national, provincial or local sphere of government. The effect of the decision is that planning and other authorities which derive their statutory mandate and powers from other legislation retain all their powers as regards planning and rezoning, for instance. In addition, the Minister of Mineral Resources cannot make a decision on behalf of, or for, such functionaries. The judgement also clarified the question of whether or not a national Act can supersede provincial legislation dealing with a distinctly different functional domain. In principle, the decision also indicates that the fact that a range of authorisations are required in terms of separate statutory instruments (each with its own functional domain and administered by its own functionary) does not necessarily amount to conflicts between these instruments. An owner of land may now insist that his land may not be used for mining purposes if it is not zoned for such purposes. It is submitted that, in order to provide certainty to land owners, developers and government functionaries, and to promote investor confidence (especially in the mining sector), an intergovernmental system for the consideration of applications by the functionaries responsible for the separate statutory instruments needs to be developed as a high priority.
- Published
- 2012
6. STATE LIABILITY FOR FINAL COURT ORDERS SOUNDING IN MONEY: AT LONG LAST ALIGNMENT WITH THE CONSTITUTION
- Author
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Clara Williams and Nic Olivier
- Subjects
Constitution ,Limited liability ,Political science ,media_common.quotation_subject ,Strict liability ,Law ,State liability ,Legislation ,Liability insurance ,Constitutional court ,State immunity ,media_common - Abstract
Since the commencement of the State Liability Act 20 of 1957 the (until 2011) prevailing legislation rendered it almost impossible to satisfy judgment debts sounding in money against the State. There has been a continuous struggle in South Africa “to reach a balance between State immunity from tort liability and government accountability to the State’s citizens”. The State Liability Amendment Act of 2011 (following on the Constitutional Court’s decision in Nyathi v MEC for Department of Health Gauteng 2008 5 SA 94 (CC)) will enable judgment creditors to obtain effective relief against the State.
- Published
- 2021
- Full Text
- View/download PDF
7. The effect of course work in consumer buying upon certain buying practices of negro students
- Author
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Clara Williams Woods
- Subjects
Work (electrical) ,Marketing ,Psychology ,Consumer education ,Course (navigation) - Published
- 2018
- Full Text
- View/download PDF
8. P575: The Rare Genomes Project: Improving access to genomic sequencing and identifying causes of rare disease
- Author
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Christina Austin-Tse, Stephanie DiTroia, Melanie O'Leary, Grace VanNoy, Brian Mangilog, Gulalai Shah, Eva Martinez, Jillian Serrano, Lynn Pais, Emily O'Heir, Ikeoluwa Osei-Owusu, Gabrielle Lemire, Vijay Ganesh, Sarah Stenton, Mutaz Amin, Kayla Socarras, Mugdha Singh, Stacey Hall, Katie Larsson, Moriel Singer-Berk, Daniel Marten, Michael Wilson, Hana Snow, Benjamin Blankenmeister, Jialan Ma, Ben Weisburd, Alba Sanchis-Juan, Harrison Brand, Emily Groopman, Alysia Lovgren, Clara Williamson, Marissa Hollyer, Eleina England, Eleanor Seaby, Katherine Chao, Julia Goodrich, Samantha Baxter, Daniel MacArthur, Michael Talkowski, Monica Wojcik, Anne O'Donnell-Luria, and Heidi Rehm
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Genetics ,QH426-470 ,Medicine - Published
- 2024
- Full Text
- View/download PDF
9. Scrub Growth
- Author
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Smith, Clara Williams
- Published
- 1937
10. Vats of Golden Soup
- Author
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Smith, Clara Williams
- Published
- 1937
11. By a Nameless Lake
- Author
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Smith, Clara Williams
- Published
- 1937
12. QUIT PLASTIC.
- Author
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Roldan, Clara Williams and Williams, Louise
- Subjects
PLASTICS & the environment ,WASTE management ,SUSTAINABILITY - Abstract
An excerpt from the book "Quitting Plastic: Easy and Practical Ways to Cut Down the Plastic in Your Life" by Clara Williams Roldan and Louise Williams is presented.
- Published
- 2019
13. Maccsand (Pty) Ltd v City of Cape Town 2012 (4) SA 181 (CC)
- Author
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Pieter Badenhorst, Clara Williams, and Nic Olivier
- Subjects
Government ,Sociology and Political Science ,Land use ,Statutory law ,Law ,Judgement ,Economics ,Mandate ,Legislation ,Obligation ,Constitutional court - Abstract
The Constitutional Court in Maccsand (Pty) Ltd v City of Cape Town (CCT 103/11) 2012 ZACC 7 decided that the granting of mining rights or mining permits by the Minister of Mineral Resources in terms of the Mineral and Petroleum Resources Development Act 28 of 2002 does not obviate the obligation on an applicant to obtain authorisations in terms of other legislation that deals with functional domains other than minerals, mining and prospecting. This applies to all other legislation, irrespective of whether the responsible administrator of such other legislation is in the national, provincial or local sphere of government. The effect of the decision is that planning and other authorities which derive their statutory mandate and powers from other legislation retain all their powers as regards planning and rezoning, for instance. In addition, the Minister of Mineral Resources cannot make a decision on behalf of, or for, such functionaries. The judgement also clarified the question of whether or not a national Act can supersede provincial legislation dealing with a distinctly different functional domain. In principle, the decision also indicates that the fact that a range of authorisations are required in terms of separate statutory instruments (each with its own functional domain and administered by its own functionary) does not necessarily amount to conflicts between these instruments. An owner of land may now insist that his land may not be used for mining purposes if it is not zoned for such purposes. It is submitted that, in order to provide certainty to land owners, developers and government functionaries, and to promote investor confidence (especially in the mining sector), an intergovernmental system for the consideration of applications by the functionaries responsible for the separate statutory instruments needs to be developed as a high priority.
- Published
- 2013
- Full Text
- View/download PDF
14. Case Notes: Wary Holdings (Pty) Ltd v Stalwo (Pty) Ltd & Another (Trustees of the Hoogekraal Highlands Trust & SAFAMCO Enterprises (Pty) Ltd (amicus curiae); Minister of Agriculture & Land Affairs (intervening)) [2008] JOL 22099 (CC)
- Author
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Clara Williams and Nic Olivier
- Subjects
Negative - answer ,De facto ,Jurisdiction ,Agriculture ,business.industry ,Agricultural land ,Law ,Sociology ,Theology ,business - Abstract
In terms of the Subdivision of Agricultural Land Act 70 of 1970, the (national) Minister of Agriculture, Forestry and Fisheries has to authorise, in writing, every application for the subdivision of agricultural land. The following proviso was added to the definition of 'agricultural land' in the Act in 1995: "Provided that land situated in the area of jurisdiction of a transitional council as defined in section 1 of the Local Government Transition Act, 1993 (Act No. 209 of 1993), which immediately prior to the first election of the members of such transitional council was classified as agricultural land, shall remain classified as such." The question that arose in this case was whether the proviso only existed during the lifetime of transitional councils. An affirmative answer to the above question would result in the de facto and de jure implicit termination (and disappearance) of agricultural land as a category in South African law and, consequently, of the Minister's power to approve any subdivision of agricultural land. A negative answer would imply that agricultural land remains as a category, that the provisions of SALA need to be complied with, and that the Minister's written approval needs to be obtained for each and every application for subdivision of agricultural land. This article contends that the Constitutional Court was correct in finding that the proviso (and the Act) is still applicable today. Ingevolge die Wet op die Onderverdeling van Landbougrond 70 van 1970 moet die (nasionale) Minister van Landbou, Bosbou en Visserye alle aansoeke vir die onderverdeling van landbougrond skriftelik goedkeur. Die volgende voorbehoudsbepaling is tot die definsie van "landbougrond" in die Wet in 1995 gevoeg: "Met dien verstande dat grond gelee in die regsgebied van 'n oorgangsraad soos omskryf in artikel 1 van die Oorgangswet op Plaaslike Regering, 1993 (Wet 209 van 1993), wat onmiddellik voor die eerste verkiesing van die lede van so 'n oorgangsraad as landbougrond geklassifiseer was, as sodanig geklassifiseer bly". Die vraag wat in hierdie saak beslis moes word, is of die voorbehoudsbepaling slegs tydens die bestaan van die oorgangsrade gegeld het. 'n Bevestigende antwoord sou die de facto en de jure geimpliseerde beeindiging (en verdwyning) van landbougrond as 'n kategorie in die Suid-Afrikaanse reg en, gevolglik, van die Minister se mag om die onderverdeling daarvan goed te keur, tot gevolg he. 'n Negatiewe antwoord sou impliseer dat landbougrond as 'n kategorie bly voortbestaan, dat daar aan die bepalings van die Wet voldoen moet word, en dat die Minister se skriftelike toestemming steeds vereis word vir elke aansoek vir die onderverdeling van landbougrond. Hierdie artikel doen aan die hand dat die Konstitusionele Hof die korrekte beslissing gemaak het deur te bevind dat die voorbehoudsbepaling (en die Wet) steeds vandag van toepassing is.
- Published
- 2011
- Full Text
- View/download PDF
15. Rural development within the context of development, sustainability and rural issues - some constitutional, policy and implementation perspectives
- Author
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Clara Williams, C Van Zyl, and Nic Olivier
- Subjects
Economic growth ,Sociology and Political Science ,media_common.quotation_subject ,development objectives ,Context (language use) ,The Republic ,Reconstruction and Development Programme ,03 medical and health sciences ,0302 clinical medicine ,0504 sociology ,Sustainable development ,Political science ,11. Sustainability ,lcsh:Law in general. Comparative and uniform law. Jurisprudence ,Rural development ,Constitutional law ,Constitutional law and development ,media_common ,Government ,sustainable development ,Constitution ,05 social sciences ,1. No poverty ,050401 social sciences methods ,050301 education ,030206 dentistry ,Rural development policy ,Development objectives ,050903 gender studies ,constitutional law and development ,lcsh:K1-7720 ,Sustainability ,0509 other social sciences ,rural development policy ,0503 education ,Law ,rural development - Abstract
This article provides an overview of some developments, internationally, regionally and in the SADC, in relation to development, that may be expected to influence the South African government’s response to the development needs of the people in the country. An overview is provided of the somewhat haphazard way in which the Constitution of the Republic of South Africa, 1996 refers to the need for and objective of development (including rural development) in the country. Through their explanatory outline of three distinct phases in South African rural development law and policy: 1994–2000 (the Reconstruction and Development Programme and related documents and their implementation); 2000–April 2009 (the Integrated Sustainable Rural Development Strategy and its implementation) and April 2009+ (the Comprehensive Rural Development Programme and related documents), the authors review some of the historical strengths and future prospects related to rural development in South Africa. Based on an assessment of historical trends, a number of recommendations are made for government’s way forward in the implementation of the constitutional objectives, law and policy relevant to rural development in the country. Keywords : rural development; sustainable development; constitutional law and development; development objectives; rural development policy
- Published
- 2010
- Full Text
- View/download PDF
16. Altitude training experiences and perspectives: survey of 67 professional pilots
- Author
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Carla, Hackworth, Linda, Peterson, Dan, Jack, and Clara, Williams
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Adult ,Male ,Aircraft ,Data Collection ,Teaching ,Altitude Sickness ,Middle Aged ,Attitude ,Surveys and Questionnaires ,Workforce ,Humans ,Aviation ,Hypoxia ,Aged ,Program Evaluation - Abstract
Pilots and crewmembers of flights exceeding 7620 m/mean sea level (msl) are required to complete ground training in high-altitude physiology, including hypoxia training. However, regulations do not require altitude chamber training (ACT).An anonymous questionnaire concerning their experiences and perceptions of hypoxia training was filled out by 67 pilots attending an aviation safety conference. All pilots had logged professional business flight hours in the previous 6 mo.There were 62 pilots who reported receiving hypoxia training, and of these, 71% reported having initial ACT. Most of the pilots surveyed agreed that all pilots should receive introductory hypoxia training (92%), recurrent hypoxia training (86%), initial ACT (85%), and recurrent ACT (70%). Initial ACT received lower endorsements for private (32%) or recreational (10%) pilots than for commercial (74%) and air transport (90%) pilots. When asked if ACT should be based on the altitude capability of an aircraft, 59% responded affirmatively. Apparently, the perceived need for ACT was based on the likelihood of flying at higher altitudes and not simply the level of certification. When asked if the current regulations (i.e., not requiring ACT) addressing high-altitude flying (above 7620 m/msl) are sufficient, 52% of the current sample disagreed or strongly disagreed.Generally, these professional pilots perceived that pilot training should include introductory hypoxia training, recurrent hypoxia training, and ACT. Exceptions were initial ACT for recreational pilots and private pilots. Generalizability of these results may be affected by the specificity and size of the sample. Distributing the survey to a wider audience of pilots would provide additional information regarding perceptions of hypoxia training.
- Published
- 2005
17. THE ART OF Really Quitting Plastic.
- Author
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Roldan, Clara Williams
- Published
- 2019
18. The effect of course work in consumer buying upon certain buying practices of negro students ...
- Author
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Woods, Clara Williams, primary
- Full Text
- View/download PDF
19. The Italian
- Author
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(1886), Reginald Barker, director, (1882), Thomas H. Ince, producer, (1867), J. Frank Burke, performer, (1888), Clara Williams, performer, and (1873), George Beban, performer
- Published
- 1915
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