23 results on '"Claeys, M.J."'
Search Results
2. Impaired coronary flow reserve after a recent myocardial infarction: Correlation with infarct size and extent of microvascular obstruction
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Van Herck, P.L., Paelinck, B.P., Haine, S.E., Claeys, M.J., Miljoen, H., Bosmans, J.M., Parizel, P.M., and Vrints, C.J.
- Published
- 2013
- Full Text
- View/download PDF
3. Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process
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Moens, A.L., Claeys, M.J., Timmermans, J.P., and Vrints, C.J.
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- 2005
- Full Text
- View/download PDF
4. Coronary microvascular dysfunction after myocardial infarction: increased coronary zero flow pressure both in the infarcted and in the remote myocardium is mainly related to left ventricular filling pressure
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Herck, P.L. Van, Carlier, S.G., Claeys, M.J., Haine, S.E., Gorissen, P., Miljoen, H., Bosmans, J.M., and Vrints, C.J.
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Cardiac output -- Research ,Heart attack -- Patient outcomes ,Heart attack -- Physiological aspects ,Heart attack -- Research ,Coronary arteries -- Physiological aspects ,Heart ventricle, Left -- Physiological aspects ,Health - Published
- 2007
5. Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes
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Lettino, M., Andell, P., Zeymer, U., Widimsky, P., Danchin, N., Bardaji, A., Barrabes, J.A., Cequier, A., Claeys, M.J., Luca, L. de, Dorler, J., Erlinge, D., Erne, P., Goldstein, P., Koul, S.M., Lemesle, G., Luscher, T.F., Matter, C.M., Montalescot, G., Radovanovic, D., Sendon, J.L., Tousek, P., Weidinger, F., Weston, C.F.M., Zaman, A., Li, J., Jukema, J.W., PIRAEUS Grp, and PIRAEUS Grp
- Subjects
Male ,Ticagrelor ,Prasugrel ,Time Factors ,Type 2 diabetes ,030204 cardiovascular system & hematology ,ST-segment elevation ,0302 clinical medicine ,Diabetes mellitus ,Recurrence ,Risk Factors ,Pharmacology (medical) ,030212 general & internal medicine ,Myocardial infarction ,Hospital Mortality ,Registries ,Coronary Artery Bypass ,Practice Patterns, Physicians' ,610 Medicine & health ,Non-ST Elevated Myocardial Infarction ,Observational ,education.field_of_study ,Middle Aged ,Clopidogrel ,Prognosis ,Europe ,P2Y12 receptor inhibitors ,Female ,Cardiology and Cardiovascular Medicine ,medicine.drug ,medicine.medical_specialty ,Population ,Hemorrhage ,Acute coronary syndromes ,Risk Assessment ,03 medical and health sciences ,Percutaneous Coronary Intervention ,Internal medicine ,medicine ,Humans ,Angina, Unstable ,Acute Coronary Syndrome ,Antiplatelets ,education ,Aged ,business.industry ,Unstable angina ,medicine.disease ,Non-ST-segment elevation ,Diabetes Mellitus, Type 1 ,Diabetes Mellitus, Type 2 ,Relative risk ,ST Elevation Myocardial Infarction ,Human medicine ,business ,Platelet Aggregation Inhibitors - Abstract
Aims Among patients with acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at particularly high risk of recurrent cardiovascular events and premature death. We aimed to provide a descriptive overview of unadjusted analyses of patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in contemporary registries in Europe. Methods and results A total of 10 registries provided data in a systematic manner on ACS patients with DM (total n =28 899), and without DM (total n= 97 505). In the DM population, the proportion of patients with ST-Segment Elevation Myocardial Infarction (STEMI) ranged from 22.1% to 64.6% (other patients had non-ST-Segment Elevation Myocardial Infarction (NSTEMI-ACS) or unstable angina). All-cause mortality in the registries ranged from 1.4% to 9.4% in-hospital; 2.8% to 7.9% at 30 days post-discharge; 5.1% to 10.7% at 180 days post-discharge; and 3.3% to 10.5% at 1 year post-discharge. Major bleeding events were reported in up to 3.8% of patients while in hospital (8 registries); up to 1.3% at 30 days (data from two registries only), and 2.0% at 1 year (one registry only). Registries differed substantially in terms of study setting, site, patient selection, definition and schedule of endpoints, and use of various P2Y12 inhibitors. In most, but not all, registries, event rates in DM patients were higher than in patients without DM. Pooled risk ratios comparing cohorts with DM vs. no DM were in-hospital significantly higher in DM for all-cause death (1.66; 95% CI 1.42-1.94), for cardiovascular death (2.33; 1.78 - 3.03), and for major bleeding (1.35; 1.21-1.52). Conclusion These registry data from real-life clinical practice confirm a high risk for recurrent events among DM patients with ACS, with great variation across the different registries.
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- 2017
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6. Editor's Choice-The organization of chest pain units: Position statement of the Acute Cardiovascular Care Association
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Claeys, M.J. (Marc J.), Ahrens, I. (Ingo), Sinnaeve, P.R. (Peter), Diletti, R. (Roberto), Rossini, R. (Roberta), Goldstein, P. (Patrick), Czerwińska, K. (Kasia), Bueno, H. (Hector), Lettino, M., Munzel, T. (Thomas), Zeymer, U. (Uwe), Claeys, M.J. (Marc J.), Ahrens, I. (Ingo), Sinnaeve, P.R. (Peter), Diletti, R. (Roberto), Rossini, R. (Roberta), Goldstein, P. (Patrick), Czerwińska, K. (Kasia), Bueno, H. (Hector), Lettino, M., Munzel, T. (Thomas), and Zeymer, U. (Uwe)
- Abstract
Chest pain units are defined as organizational short stay units with specific management protocols designed to facilitate and optimize the diagnosis of patients presenting with chest pain in the emergency department. The present document is intended to standardize and facilitate the installation of chest pain units nearby to the emergency department or as an integral part of the emergency department. Recommendations on organizational structure, physical and technical requirements and on disease management are presented. More standardized installation and implementation of chest pain units will enhance the quality of chest pain units and improve the quality of care of our chest pain patients.
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- 2017
- Full Text
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7. Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: Current status in 37 ESC countries
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Kristensen, S.D. Laut, K.G. Fajadet, J. Kaifoszova, Z. Kala, P. Di Mario, C. Wijns, W. Clemmensen, P. Agladze, V. Antoniades, L. Alhabib, K.F. De Boer, M.-J. Claeys, M.J. Deleanu, D. Dudek, D. Erglis, A. Gilard, M. Goktekin, O. Guagliumi, G. Gudnason, T. Hansen, K.W. Huber, K. James, S. Janota, T. Jennings, S. Kajander, O. Kanakakis, J. Karamfiloff, K.K. Kedev, S. Kornowski, R. Ludman, P.F. Merkely, B. Milicic, D. Najafov, R. Nicolini, F.A. Noč, M. Ostojic, M. Pereira, H. Radovanovic, D. Sabaté, M. Sobhy, M. Sokolov, M. Studencan, M. Terzic, I. Wahler, S. Widimsky, P.
- Abstract
Aims: Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI). We conducted this study to evaluate the contemporary status on the use and type of reperfusion therapy in patients admitted with STEMI in the European Society of Cardiology (ESC) member countries. Methods and results A cross-sectional descriptive study based on aggregated country-level data on the use of reperfusion therapy in patients admitted with STEMI during 2010 or 2011. Thirty-seven ESC countries were able to provide data from existing national or regional registries. In countries where no such registries exist, data were based on best expert estimates. Data were collected on the use of STEMI reperfusion treatment and mortality, the numbers of cardiologists, and the availability of PPCI facilities in each country. Our survey provides a brief data summary of the degree of variation in reperfusion therapy across Europe. The number of PPCI procedures varied between countries, ranging from 23 to 884 per million inhabitants. Primary percutaneous coronary intervention and thrombolysis were the dominant reperfusion strategy in 33 and 4 countries, respectively. The mean population served by a single PPCI centre with a 24-h service 7 days a week ranged from 31 300 inhabitants per centre to 6 533 000 inhabitants per centre. Twenty-seven of the total 37 countries participated in a former survey from 2007, and major increases in PPCI utilization were observed in 13 of these countries. Conclusion Large variations in reperfusion treatment are still present across Europe. Countries in Eastern and Southern Europe reported that a substantial number of STEMI patients are not receiving any reperfusion therapy. Implementation of the best reperfusion therapy as recommended in the guidelines should be encouraged. All rights reserved. © 2014 The Author.
- Published
- 2014
8. Guidelines on the management of valvular heart disease (version 2012)
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Vahanian, A., Alfieri, O., Andreotti, F., Antunes, M.J., Baron-Esquivias, G., Baumgartner, H., Borger, M.A., Carrel, T.P., Bonis, M. de, Evangelista, A., Falk, V., Iung, B., Lancellotti, P., Pierard, L., Price, S., Schafers, H.J., Schuler, G., Stepinska, J., Swedberg, K., Takkenberg, J., Oppell, U.O. von, Windecker, S., Zamorano, J.L., Zembala, M., Bax, J.J., Ceconi, C., Dean, V., Deaton, C., Fagard, R., Funck-Brentano, C., Hasdai, D., Hoes, A., Kirchhof, P., Knuuti, J., Kolh, P., McDonagh, T., Moulin, C., Popescu, B.A., Reiner, Z., Sechtem, U., Sirnes, P.A., Tendera, M., Torbicki, A., Segesser, L. von, Badano, L.P., Bunc, M., Claeys, M.J., Drinkovic, N., Filippatos, G., Habib, G., Kappetein, A.P., Kassab, R., Lip, G.Y.H., Moat, N., Nickenig, G., Otto, C.M., Pepper, J., Piazza, N., Pieper, P.G., Rosenhek, R., Shuka, N., Schwammenthal, E., Schwitter, J., Mas, P.T., Trindade, P.T., Walther, T., Task Force Members, ESC Comm Practice Guidelines CPG, and Document Reviewers
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Aortic stenosis ,Percutaneous valve intervention ,Valve surgery ,Valve disease ,Mitral regurgitation - Published
- 2012
9. Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries
- Author
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Kristensen, S.D., Laut, K.G., Fajadet, J., Kaifoszova, Z., Kala, P., Mario, C. de, Wijns, W., Clemmensen, P., Agladze, V., Antoniades, L., Alhabib, K.F., Boer, M.J. de, Claeys, M.J., Deleanu, D., Dudek, D., Erglis, A., Gilard, M., Goktekin, O., Guagliumi, G., Gudnason, T., Hansen, K.W., Huber, K., James, S., Janota, T., Jennings, S., Kajander, O., Kanakakis, J., Karamfiloff, K.K., Kedev, S., Kornowski, R., Ludman, P.F., Merkely, B., Milicic, D., Najafov, R., Nicolini, F.A., Noc, M., Ostojic, M., Pereira, H., Radovanovic, D., Sabate, M., Sobhy, M., Sokolov, M., Studencan, M., Terzic, I., Wahler, S., Widimsky, P., et al., Kristensen, S.D., Laut, K.G., Fajadet, J., Kaifoszova, Z., Kala, P., Mario, C. de, Wijns, W., Clemmensen, P., Agladze, V., Antoniades, L., Alhabib, K.F., Boer, M.J. de, Claeys, M.J., Deleanu, D., Dudek, D., Erglis, A., Gilard, M., Goktekin, O., Guagliumi, G., Gudnason, T., Hansen, K.W., Huber, K., James, S., Janota, T., Jennings, S., Kajander, O., Kanakakis, J., Karamfiloff, K.K., Kedev, S., Kornowski, R., Ludman, P.F., Merkely, B., Milicic, D., Najafov, R., Nicolini, F.A., Noc, M., Ostojic, M., Pereira, H., Radovanovic, D., Sabate, M., Sobhy, M., Sokolov, M., Studencan, M., Terzic, I., Wahler, S., Widimsky, P., and et al.
- Abstract
Item does not contain fulltext, AIMS: Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI). We conducted this study to evaluate the contemporary status on the use and type of reperfusion therapy in patients admitted with STEMI in the European Society of Cardiology (ESC) member countries. METHODS AND RESULTS: A cross-sectional descriptive study based on aggregated country-level data on the use of reperfusion therapy in patients admitted with STEMI during 2010 or 2011. Thirty-seven ESC countries were able to provide data from existing national or regional registries. In countries where no such registries exist, data were based on best expert estimates. Data were collected on the use of STEMI reperfusion treatment and mortality, the numbers of cardiologists, and the availability of PPCI facilities in each country. Our survey provides a brief data summary of the degree of variation in reperfusion therapy across Europe. The number of PPCI procedures varied between countries, ranging from 23 to 884 per million inhabitants. Primary percutaneous coronary intervention and thrombolysis were the dominant reperfusion strategy in 33 and 4 countries, respectively. The mean population served by a single PPCI centre with a 24-h service 7 days a week ranged from 31 300 inhabitants per centre to 6 533 000 inhabitants per centre. Twenty-seven of the total 37 countries participated in a former survey from 2007, and major increases in PPCI utilization were observed in 13 of these countries. CONCLUSION: Large variations in reperfusion treatment are still present across Europe. Countries in Eastern and Southern Europe reported that a substantial number of STEMI patients are not receiving any reperfusion therapy. Implementation of the best reperfusion therapy as recommended in the guidelines should be encouraged.
- Published
- 2014
10. Put into practice of reperfusion treatment in ST segment elevation myocardial infarction (STEMI: ST segment elevation myocardial infarction). [Mise en place du traitement de reperfusion dans les infarctus du myocarde avec élévation du segment ST]
- Author
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UCL - (MGD) Services des soins intensifs, Claeys, M.J., Gevaert, S., De Meester, A., Evrard, Patrick, Legrand, V., Vrints, Ch., Berkenboom, G., Desmet, W., Van Langenhove, G., Vranckx, P., Van De Werf, Fr., Vandenbranden, Fr., UCL - (MGD) Services des soins intensifs, Claeys, M.J., Gevaert, S., De Meester, A., Evrard, Patrick, Legrand, V., Vrints, Ch., Berkenboom, G., Desmet, W., Van Langenhove, G., Vranckx, P., Van De Werf, Fr., and Vandenbranden, Fr.
- Abstract
Myocardial infarction remains a major healthcare problem. Reperfusion therapy has been shown to influence favourably short- and long-term patient survival. The authors reviewed the data of early recognition of STEMI (ST Elevation Myocardial Infarction), the reperfusion modalities including a flowchart management, as proposed by the Belgian working groups (BIWAC and BWGIC), and the lessons learned from European and American registries. Primary PCI often remains the treatment of choice. A national policy is still required to implement the guidelines and improve clinical practice for our STEMI patients.
- Published
- 2010
11. Implementation of reperfusion therapy in ST-segment elevation myocardial infarction a policy statement from the Belgian Society of Cardiology (BSC), the Belgian Interdisciplinary Working Group on Acute Cardiology (BIWAC) and the Belgian Working Group on Interventional Cardiology (BWGIC)
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UCL - (MGD) Services des soins intensifs, Claeys, M.J., Gevaert, S., De Meester, A., Evrard, Patrick, Legrand, V., Vrints, C., Berkenboom, G., Desmet, W., Van Langenhove, G., Vranckx, P., De Raedt, H., Van De Werf, F., Van Den Branden, F., UCL - (MGD) Services des soins intensifs, Claeys, M.J., Gevaert, S., De Meester, A., Evrard, Patrick, Legrand, V., Vrints, C., Berkenboom, G., Desmet, W., Van Langenhove, G., Vranckx, P., De Raedt, H., Van De Werf, F., and Van Den Branden, F.
- Abstract
not available
- Published
- 2009
12. Recommandations pratiques pour le traitement d'arythmies aiguës: Rapport du Groupe Interdisciplinaire Belge de Cardiologie Aiguë
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UCL - (SLuc) Département cardiovasculaire, UCL - (MGD) Services des soins intensifs, Gevaert, S., Vandekerckhove, Y., De Raedt, H., Renard, M., Hollanders, G., Bossaert, L., Vorlat, A., Calle, P., Martens, P., Evrard, P., Salembier, J., Verbeet, T., Van Overschelde, J.L., Claeys, M.J., De Meester, Antoine, UCL - (SLuc) Département cardiovasculaire, UCL - (MGD) Services des soins intensifs, Gevaert, S., Vandekerckhove, Y., De Raedt, H., Renard, M., Hollanders, G., Bossaert, L., Vorlat, A., Calle, P., Martens, P., Evrard, P., Salembier, J., Verbeet, T., Van Overschelde, J.L., Claeys, M.J., and De Meester, Antoine
- Abstract
Les arythmies aiguës comprennent une variété large de troubles du rythme. Les auteurs proposent des recommandations pratiques pour l’approche et le traitement du patient souffrant d’une arythmie aiguë. Ainsi sont discutées les brady-cardies et les tachycardies. Les tachycardies sont divisées en tachycardies à complexes QRS fins et celles à complexes larges. Par ailleurs, une importante distinction concernant la stabilité hémodynamique du patient est faite ; celle-ci va entraîner des conséquences thérapeutiques immédiates. Des arbres décisionnels clairs avec schémas diagnostiques et thérapeutiques des différentes arythmies sont proposés, de même que les considérations pratiques concernant la cardioversion électrique.
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- 2005
13. 186 Donor B-Type Natriuretic Peptide Predicts Early Cardiac Performance after Heart Transplantation
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Vorlat, A., primary, Conraads, V.M., additional, Jorens, P.G., additional, Rodrigus, I., additional, and Claeys, M.J., additional
- Published
- 2011
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14. Simultaneous digitization of intracoronary doppler and pressure to assess the influence of diastolic dysfunction on the hyperemic coronary pressure-flow relationship after myocardial infarction
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Van Herck, P.L., primary, Claeys, M.J., additional, Haine, S.E., additional, Gorissen, P., additional, Miljoen, H., additional, Bosmans, J.M., additional, Vrints, C.J., additional, and Carlier, S.G., additional
- Published
- 2006
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15. Summary 2013 ESC guidelines
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Claeys, M.J., Borne, P. Van De, Mairesse, G.H., and Camp, G. Van
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- 2014
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- View/download PDF
16. Inter-hospital variation in length of hospital stay after ST-elevation myocardial infarction: results from the Belgian STEMI registry
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Claeys, M.J., Sinnaeve, P.R., Convens, C., Dubois, P., Boland, J., Vranckx, P., Gevaert, S., Coussement, P., Beauloye, C., Renard, M., and Vrints, C.
- Published
- 2013
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17. Summary of 2012 ESC Guidelines
- Author
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Claeys, M.J., Evrard, P., Gurné, O., Mairesse, G., Vandekerkhove, Y., Sutter, J. De, and Legrand, V.
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- 2013
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18. The determinants of B-type natriuretic peptide release in acute, non-ST-segment elevation myocardial infarction
- Author
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Vorlat, A., Claeys, M.J., Snoep, L., Haine, S., Miljoen, H., Bosmans, J., and Vrints, C.J.
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- 2011
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19. Effect of stenting on coronary flow velocity reserve: comparison of coil and tubular stents
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Vrints, C.J., Claeys, M.J., Bosmans, J., Conraads, V., and Snoeck, J.P.
- Abstract
ObjectiveTo determine whether coil stents are as effective as tubular stents in improving coronary flow velocity reserve (CFVR) after stent deployment. MethodsDistal CFVR was measured with a 0.014 inch Doppler guide wire before and after stenting in 33 patients. A coil stent was implanted in 16 patients and a tubular stent was used in 17 patients. Coronary flow velocity within the stent was also recorded during a slow pullback. ResultsFollowing placement of the stents, the percentage diameter stenosis was similar for both the tubular and coil stents (mean (SE) 11 (2)% v 13 (2)%, NS). However, distal CFVR was higher after stenting with a tubular stent compared with a coil stent (2.46 (0.13) v 1.96 (0.14), p < 0.05). Furthermore, pullback through the stent detected a major flow velocity increase within coil stents but not in tubular stents (83 (24)% v 5 (5)%, p < 0.05). ConclusionsIn spite of similar angiographic improvement, placement of coil stents was associated with inferior functional results compared with tubular stents. The flow velocity acceleration within the coil stents suggests the presence of a residual narrowing within the stent, which is not appreciated on angiography.
- Published
- 1999
20. 466 Folic acid prevents ischemia/reperfusion-injury, an in vitro and in vivo study
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Moens, A.L., Claeys, M.J., Borgonjon, D.J., Ter Loo, F., Van Daele, J.E., Timmermans, J.P., and Vrints, C.J.
- Subjects
- *
FOLIC acid , *ISCHEMIA - Abstract
An abstract of the study "Folic acid prevents ischemia/reperfusion-injury, an in vitro and in vivo study," by A. L. Moens and colleagues is presented.
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- 2004
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21. 338 Folic acid protects against coronary endothelial dysfunction
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Moens, A.L., Claeys, M.J., Timmermans, J.P., and Vrints, C.J.
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FOLIC acid , *CORONARY disease - Abstract
An abstract of the article "Folic Acid Protects Against Coronary Endothelial Dysfunction," by A. L. Moens et al is presented.
- Published
- 2004
22. Abstracts
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Barthelemy, O., Silvain, J., Brieger, D., Bellemain-Appaix, A., Cayla, G., Beygui, F., Lancar, R., Collet, J.P., Mercadier, A., Montalescot, G., Cha, K.S., Nam, Y.H., Kim, J.H., Park, S.Y., Park, T.H., Kim, M.H., Kim, Y.D., Lee, H.C., Ahn, M.S., Hong, T.J., Blanco, R., Blanco, F., Szarfer, J., Garcia Escudero, A., Gigena, G., Gagliardi, J., Rodriguez, A., Sarmiento, R., Affatatto, S., Riccitelli, M., Petris, A., Datcu, M.D., Pop, C., Radoi, M., Arsenescu-Georgescu, C., Petrescu, I., Petrescu, L., Serban, L., Nechita, E., Tatu-Chitoiu, G., Tatu-Chitoiu, G., Dorobantu, M., Benedek, I., Craiu, E., Sinescu, C., Ionescu, D.D., Radoi, M., Pop, C., Ginghina, C., Minescu, B., Izzo, A., Mantovani, P., Tomasi, L., Dalloglio, L., Bonatti, S., Rosiello, R., Romano, M., Agostini, F., Zanini, R., Zhao, Z.Y., Wu, Y.J., Li, J.J., Yany, Y.J., Qian, H.Y., Tang, Y.D., Timoteo, A.T., Toste, A., Lousinha, A., Ramos, R., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Cabades, C., Diez Gil, J.L., Aguar, P., Sanmiguel, D., Lopez-March, A., Marmol, R., Guerra, L., Girbes, V., Ferrando, J., Rincon De Arellano, A., Timoteo, A.T., Ramos, R., Toste, A., Oliveira, J.A., Patricio, L., Ferreira, M.L., Ferreira, R.C., Blondal, M., Ainla, T., Marandi, T., Eha, J., Timoteo, A.T., Oliveira, M.M., Silva, M.N., Cunha, P.S., Feliciano, J., Silva, S., Ferreira, R.C., Kanovsky, J., Kala, P., Parenica, J., Poloczek, M., Prymusova, K., Kubkova, L., Spinar, J., Olinic, D., Homorodean, C., Ober, M., Olinic, M., Andrioaia, C., Condac, A., Masmoudi, M., Berdaoui, B., Labidi, S., Tapia Ballesteros, C., Hernandez Luis, C., Sandin, M.G., Vegas, J.M., Andion, R., Martinez, N., Gonzalez, I.A., Alvarado, M., Amat, I.J., San Roman, J.A., Garcia Gonzalez, M.J., Arroyo Ucar, E., Hernandez Garcia, C., Dorta Martin, M., Marrero Rodriguez, F., Dragu, R., Kapeliovich, M., Hammerman, H., Silva, D., Cortez-Dias, N., Jorge, C., Silva Marques, J., Carilho Ferreira, P., Robalo Martins, S., Almeida Ribeiro, M., Calisto, C., Fiuza, M., Lopes, M.G., Milicevic, P., Panic, M., Stankovic, I., Milicevic, D., Kalezic, T., Kafedzic, S., Ilic, I., Cerovic, M., Putnikovic, B., Neskovic, A., Rott, D., Leibowitz, D., Monhart, Z., Reissigova, J., Grunfeldova, H., Jansky, P., Timoteo, A.T., Valente, B., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Villanueva Benito, I., Solla, I., Paredes, E., Diaz Castro, O., Calvo, F., Baz, J.A., Iniguez, A., Aleksova, A., Gerloni, R., Belfiore, R., Carriere, C., Barbati, G., Fabris, E., Possa, F., Nait, D., Milo, M., Sinagra, G., Marques, N., Mimoso, J., Gomes, V., Agra Bermejo, R.M., Emad Abu Assi, E.A.A., Sergio Raposeiras Roubin, S.R.R., Pilar Cabanas Grandio, P.C.G., Carlos Pena Gil, C.P.G., Jose Maria Garcia Acuna, J.M.G.A., Jose Ramon Gonzalez Juanatey, J.R.G.J., Daly, M.J., Scott, P., Owens, C.G., Tomlin, A., Smith, B., Adgey, A.A.J., Alvarez-Contreras, L.R., Juarez, U., Altamirano, A., Arias, A., Alvarez-San Gabriel, A., Gonzalez-Pacheco, H., Martinez-Sanchez, C., Rahnavardi, M., Keshtkar-Jahromi, M., Vakili, H., Gholamin, S., Razavi, S.M., Gilis-Januszewski, T., Mellwig, K.-P., Wiemer, M., Gilis-Januszewski, J., Peterschroeder, A., Koerfer, J., Horstkotte, D., Vrsalovic, M., Getaldic, B., Vrkic, N., Pintaric, H., Khan, S., Wasan, B., Moretti, L., Grossi, P., Silenzi, S., Testa, M., Candelori, L., Clementi, L.N., Forlini, M., Lando, L., Pezzuoli, M.L., Corradetti, P., Leurent, G., Pennec, P.Y., Filippi, E., Moquet, B., Hacot, J.P., Druelles, P., Rialan, A., Rouault, G., Coudert, I., Le Breton, H., Gevaert, S., Tromp, F., Vandecasteele, E., De Somer, F., Van Belleghem, Y., Bouchez, S., Martens, F., Herck, I., De Pauw, M., Spinar, J., Ludka, O., Sepsi, M., Miklik, R., Dusek, L., Tomcikova, D., Marques, N., Mimoso, J., Gomes, V., Garcia-Acuna, J.M., Aguiar-Souto, P., Raposeiras Roubin, S., Agra-Bermejo, R., Jacquet, M., Abu-Assi, E., Gonzalez-Juanatey, J.R., Ibatov, A., Labrova, R., Spinar, J., Karlik, R., Kanovsky, J., Lokaj, P., She, Q., Deng, S.B., Huang, 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- Abstract
Background: Radial access for PCI is increasing but its use in emergency still remains confidential. We report our single center experience where all interventional cardiologists use the radial access as default strategy for primary PCI. Methods and Results: STEMI patients (n = 671) were evaluated for bleeding complications using a web-based registry (e-PARIS). In-hospital bleeding was adjudicated using various definitions (TIMI, GUSTO, STEEPLE). MACE was the composite of death, MI and stroke. In this non-selected, high risk population, 6.1% had cardiogenic shock on admission, 3.9% out-of-hospital cardiac arrest and 51.2% multivessel disease. Radial access (88%) was the default strategy as was abciximab (78%). Clopidogrel loading dose ranged from 300 to 900 mg. Pre-hospital fibrinolysis was used in 7.1%. Hemodynamic support devices (IABP, ECMO, Tandem Heart) were needed in 7.0%. In-hospital bleeding rates varied widely according to the definitions used: 2.5%, 1.5%, 5.7%, 9.2% and 10.9% with TIMI Major, GUSTO Severe, TIMI Major/minor, GUSTO Severe/moderate or STEEPLE Major, respectively. In-hospital death rate was 5.5%. One-year mortality (8.2%) was seriously impacted by in-hospital bleeding (31.6% vs 6.8%, p < 0.001). The most frequent bleeding site was gastro-intestinal (figure). GUSTO Severe/moderate bleeding was independently correlated with MACE (OR 2.60; 95%CI 1.21–5.59; p = 0.01) and radial access was a strong predictor of survival (OR 0.33; 95%CI 0.17–0.56; p = 0.002). Conclusions: The gastro-intestinal tract is the most frequent site of bleeding when the radial artery is the predominant vascular access site for primary PCI. GUSTO Severe/moderate bleeding is an independent predictor of MACE while radial access predicts survival.
- Published
- 2010
- Full Text
- View/download PDF
23. Cardiovascular disease and COVID-19:a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA)
- Author
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Maria Dorobantu, Dirk J. Duncker, Geneviève Derumeaux, Diana A. Gorog, Zorana Vasiljevic-Pokrajcic, Cor de Wit, Marija Vavlukis, Dimitris Tousoulis, Etto C. Eringa, Edina Cenko, Christian Hassager, Davor Miličić, Teresa Padró, Giuseppe De Luca, Gemma Vilahur, Marc J. Claeys, Lina Badimon, Danijela Trifunovic-Zamaklar, Raffaele Bugiardini, Frank R. Heinzel, Olivia Manfrini, Evangelos Oikonomou, Kurt Huber, RS: Carim - H08 Experimental atrial fibrillation, Fysiologie, Physiology, ACS - Diabetes & metabolism, Cenko E., Badimon L., Bugiardini R., Claeys M.J., De Luca G., de Wit C., Derumeaux G., Dorobantu M., Duncker D.J., Eringa E.C., Gorog D.A., Hassager C., Heinzel F.R., Huber K., Manfrini O., Milicic D., Oikonomou E., Padro T., Trifunovic-Zamaklar D., Vasiljevic-Pokrajcic Z., Vavlukis M., Vilahur G., and Tousoulis D.
- Subjects
Physiology ,Disease ,Review ,CORONAVIRUS ,030204 cardiovascular system & hematology ,Bioinformatics ,endothelial dysfunction ,0302 clinical medicine ,cytokine ,Cardiometabolic Risk Factor ,thrombosi ,AcademicSubjects/MED00200 ,030212 general & internal medicine ,Endothelial dysfunction ,CARDIOLOGY ,Clinical Trials as Topic ,Sex Characteristics ,post-acute COVID-19 ,THROMBOEMBOLISM FOLLOWING HOSPITALIZATION ,Inflammation/complications ,Cardiovascular disease ,Thrombosis ,Pathophysiology ,3. Good health ,Cardiovascular Diseases ,Myocardial injury ,Cardiovascular Diseases/enzymology ,COVID-19/complications ,Angiotensin-Converting Enzyme 2 ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Infection ,Viral load ,POSITION PAPER ,Human ,ANGIOTENSIN-CONVERTING ENZYME ,EXPRESSION ,SEX-DIFFERENCES ,microcirculation ,Inflammation ,Angiotensin-Converting Enzyme 2/metabolism ,03 medical and health sciences ,Post-Acute COVID-19 Syndrome ,SDG 3 - Good Health and Well-being ,Physiology (medical) ,medicine ,Humans ,thrombosis ,business.industry ,SARS-CoV-2 ,INFLAMMATORY RESPONSE ,Cardiometabolic Risk Factors ,COVID-19 ,medicine.disease ,CARDIAC ARREST SYNDROME ,cytokines ,inflammation ,Cardiovascular Injury ,Myocardial fibrosis ,Human medicine ,business - Abstract
The cardiovascular system is significantly affected in coronavirus disease-19 (COVID-19). Microvascular injury, endothelial dysfunction, and thrombosis resulting from viral infection or indirectly related to the intense systemic inflammatory and immune responses are characteristic features of severe COVID-19. Pre-existing cardiovascular disease and viral load are linked to myocardial injury and worse outcomes. The vascular response to cytokine production and the interaction between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and angiotensin-converting enzyme 2 receptor may lead to a significant reduction in cardiac contractility and subsequent myocardial dysfunction. In addition, a considerable proportion of patients who have been infected with SARS-CoV-2 do not fully recover and continue to experience a large number of symptoms and post-acute complications in the absence of a detectable viral infection. This conditions often referred to as ‘post-acute COVID-19’ may have multiple causes. Viral reservoirs or lingering fragments of viral RNA or proteins contribute to the condition. Systemic inflammatory response to COVID-19 has the potential to increase myocardial fibrosis which in turn may impair cardiac remodelling. Here, we summarize the current knowledge of cardiovascular injury and post-acute sequelae of COVID-19. As the pandemic continues and new variants emerge, we can advance our knowledge of the underlying mechanisms only by integrating our understanding of the pathophysiology with the corresponding clinical findings. Identification of new biomarkers of cardiovascular complications, and development of effective treatments for COVID-19 infection are of crucial importance., Graphical Abstract Graphical Abstract
- Published
- 2021
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