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Introduction.-Early damage to episodic memory encoding and consolidation processes has been demonstrated in dementia of the Alzheimer type. However, in the domain of verbal episodic memory assessment, there are few diagnostic tools adapted to the old and oldest old as far as ease of administration and accuracy of normative data are concerned. Classic tasks are either too effortful (like the free recall/cued recall of 16 items), not sensitive enough (like the 5 words test), or insufficiently accurate for people above 70 years old in terms of normative data. Aim.-The aim of this study was to develop a reduced task (in terms of number of items and number of trials) assessing verbal episodic memory in people aged between 70 and 89 years old. Methods.-The task (GERIA-12) used the same procedure as the RL/RI-16 task but the list comprised only 12 words and there were only 2 learning trials. In order to assess consolidation processes, we included 2 delayed recall trials, one after 20 minutes and the other after 24 hours. We also calculated indexes adapted from the Item-Specific Deficit Approach developed by Wright et al. which has the advantage of providing measures specific to encoding, consolidation and retrieval processes. Standardization was done with data from 220 people aged between 70 and 89 years old and belonging to 3 education levels. Results.-We obtained a significant effect of age and education level: scores decrease with age and increase with education. Norms have thus been calculated taking those two variables into consideration. Concerning the standardization, Barona method has been used for free recall scores while percentiles have been used for all other scores (total recall, free recall, encoding, consolidation and retrieval indexes). Normative data are also provided for intrusions and perseverations. Conclusion.-This new task allows encoding, consolidation and retrieval processes assessment in older people and has the following advantages: the procedure, SCOPUS: re.j, info:eu-repo/semantics/published

We evaluated the sensitivity and specificity of our French version of Addenbrooke's cognitive examination (ACE) to detect dementia in our patient population. One hundred and fifty-eight cases were included in the study. In our patient series, the sensitivity for diagnosing dementia with a Mini-Mental State Examination (MMSE) score of < or = 24/30 was 48.5%, the sensitivity of an MMSE score of < or = 27/30 was 82.5% with a specificity of 72.1%, the sensitivity of an ACE score of < or = 83/100 was 86.6% with a specificity of 70.5% and the sensitivity of an ACE score of < or = 88/100 was 97.9% with a specificity of 59%. We conclude that the French version of the ACE is a very accurate test for the detection of dementia, and should be widely used in clinical practice., Comparative Study, Journal Article, info:eu-repo/semantics/published

European Federation of Neurological Society: Paris (poster with discussion), FLWIN, info:eu-repo/semantics/published

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We evaluated the Addenbrooke's cognitive examination (ACE), a simple instrument to differentiate frontotemporal dementia (FTD) from Alzheimer's disease (AD), in our dementia patients clinic population. The Verbal-Language/Orientation-Memory (VLOM) ratio, which compares its language and memory scores, determines whether FTD or AD is more likely. The ACE was translated into French with adaptation maintaining the number of words in the name and address learning and delayed recall test, and with cultural adaptation for the semantic memory. The 85 included subjects had no evidence of two or more organic pathologies, after at least six months of follow-up, and an MMSE score>or=20/30. Patients with cognitive impairment due to alcohol intake were excluded. The diagnosis of a specific dementing illness was based on the consensus of the neurologist and neuropsychologists in the team. Thereafter, another neurologist expert in dementia, blinded to the ACE result and to the diagnosis and treatment, reviewed all cases files and proposed a diagnosis. A diagnostic agreement was reached for 79 cases (92.9%) with 40 (50.6%) dementia: 25 AD (62.5 %), 9 FTD (22.5 %). We estimated that the sensitivity for detecting dementia of an ACE score3.2 was 72%,with a specificity of 69.4%. We conclude that, when used as originally proposed, ACE is very accurate for the detection of dementia, but much less effective in discriminating the most common frontal variant of FTD., Comparative Study, Journal Article, info:eu-repo/semantics/published

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Neuropsychological deficits may occur in infratentorial strokes. Only minor cognitive disturbances are reported in unilateral anterior cerebellar lesions. Here, the authors describe a patient with bilateral anterior ponto-cerebellar ischemic lesions associated with major neuropsychological deficits. Cerebral PET and SPECT demonstrated no metabolic defect in supratentorial areas., Case Reports, Journal Article, info:eu-repo/semantics/published

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The attentional blink (AB) effect is characterized by a failure to detect a second target following the identification of a previous target in a RSVP stream. This effect has been attributed to capacity limitations at a central level of visual information processes. Postperceptual models suppose that the AB locus is located in short-term memory. To test this hypothesis, we investigated the influence of a short-term memory deficit on the AB effect in a patient with such a deficit. The three main results of this study are (1) the persistence of an AB effect, (2) a large number of T1 missed identifications and (3) a T2 detection deficit for a specific delay (367 ms). These results indicate that a short-term memory deficit disrupts the processing of each target (T1 and T2) but does not product an abolition of the AB effect. © 2002 Elsevier Science (USA)., SCOPUS: ar.j, info:eu-repo/semantics/published

Confabulation is usually assumed to result from a deficit in either the memory verification processes alone or in both the search and the verification processes. The present study concerns a patient who, in contrast to other patients, displayed confabulations but had preserved memory verification abilities. She exhibited only a selective impairment of the search processes. Recognition abilities were preserved, and cued recall was better than free recall. On the latter task, she recalled fewer correct items and produced more intrusions than control subjects. The patient had normal performance in several tests usually assumed to tap "executive functions." It is thus concluded that an impairment in verification, regardless of whether it is specific or not to memory, is not a necessary component of confabulations. The case is discussed in relation to two memory control processes models (Burgess & Shallice, 1996a; Moscovitch, 1989, 1995 ;Moscovitch & Melo, 1997), to the Source Monitoring Framework (Johnson, Hashtroudi, & Lindsay, 1993), and to the Constructive Memory Framework (Schacter, Norman, & Koutstaal, 1998). We proposed new hypotheses about possible deficits in the search process so as to account for the difference between amnesic patients with and without confabulations. © 1999 Psychology Press Ltd., SCOPUS: ar.j, info:eu-repo/semantics/published

In order to launch a new transplantation program for Parkinson's disease (PD), we evaluated the safety and efficacy of fetal ventral mesencephalic grafts in 3 patients with advanced PD. Inclusion criteria and clinical evaluation followed strictly the Core Assessment Program for Intracerebral Transplantation. The transplantation procedure was based on the technique previously described by the groups in Lund (Sweden) and Créteil (France). The putamen contralateral to the site of predominant symptoms was unilaterally grafted in all patients. Magnetic resonance (MR)-based stereotactic guidance with multiplanar correlation was used to define 3 implantation trajectories in the precommissural, commissural, and postcommissural putamen. Fetal ventral mesencephalon was prepared from 6- to 8-week-old human embryos obtained from same-day abortions. Under general anesthesia, 8 deposits of 3 microliters of the fetal tissue were placed 1 mm apart along each implantation trajectory using a customized microsyringe and needle attached to the stereotactic frame. The patients recovered uneventfully from the neurosurgical procedure. Early postoperative MR clearly showed the implantation trajectories reaching the putamen in all patients. The follow-up period was of 12, 9 and 6 months, for each of the 3 patients, respectively. Clinical changes appeared between 3 and 6 months after transplantation and consisted of an increase in the 'on' periods and in quantitative bilateral improvement in the motor timed tests. There was an improvement of the Unified Parkinson's Disease Rating Scale score and an improvement of rigidity. Tremor was unchanged, and there was a slight and transient increase in dyskinesias. Neuropsychological follow-up revealed slight frontal alterations in 2 patients. Positron emission tomography demonstrated an increase of 18F-fluorodopa uptake in the grafted site. Adverse events include a reversible Cushing syndrome secondary to immunosuppression in 1 patient and a transien, Clinical Trial, Journal Article, info:eu-repo/semantics/published

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