Search

Your search keyword '"Cladel, Nancy M."' showing total 184 results
Start Over Author "Cladel, Nancy M."
184 results on '"Cladel, Nancy M."'

3. Conserved Features in Papillomavirus and Polyomavirus Capsids

Author

Belnap, David M, Olson, Norman H, Cladel, Nancy M, Newcomb, William W, Brown, Jay C, Kreider, John W, Christensen, Neil D, and Baker, Timothy S

Subjects
Biochemistry and Cell Biology, Biological Sciences, Sexually Transmitted Infections, Infectious Diseases, HIV/AIDS, Aetiology, 2.2 Factors relating to the physical environment, Infection, Animals, Antigens, Viral, Bovine papillomavirus 1, Capsid, Capsid Proteins, Cottontail rabbit papillomavirus, Humans, Papillomaviridae, Polyomavirus, Rabbits, Sequence Alignment, Simian virus 40, Viral Structural Proteins, cryoelectron microscopy, enantiomer, handedness, papovaviridae, three-dimensional image reconstruction, Medicinal and Biomolecular Chemistry, Microbiology, Biochemistry & Molecular Biology, Biochemistry and cell biology
Abstract

Capsids of papilloma and polyoma viruses (papovavirus family) are composed of 72 pentameric capsomeres arranged on a skewed icosahedral lattice (triangulation number of seven, T = 7). Cottontail rabbit papillomavirus (CRPV) was reported previously to be a T = 7laevo (left-handed) structure, whereas human wart virus, simian virus 40, and murine polyomavirus were shown to be T = 7dextro (right-handed). The CRPV structure determined by cryoelectron microscopy and image reconstruction was similar to previously determined structures of bovine papillomavirus type 1 (BPV-1) and human papillomavirus type 1 (HPV-1). CRPV capsids were observed in closed (compact) and open (swollen) forms. Both forms have star-shaped capsomeres, as do BPV-1 and HPV-1, but the open CRPV capsids are approximately 2 nm larger in radius. The lattice hands of all papillomaviruses examined in this study were found to be T = 7dextro. In the region of maximum contact, papillomavirus capsomeres interact in a manner similar to that found in polyomaviruses. Although papilloma and polyoma viruses have differences in capsid size (approximately 60 versus approximately 50 nm), capsomere morphology (11 to 12 nm star-shaped versus 8 nm barrel-shaped), and intercapsomere interactions (slightly different contacts between capsomeres), papovavirus capsids have a conserved, 72-pentamer, T = 7dextro structure. These features are conserved despite significant differences in amino acid sequences of the major capsid proteins. The conserved features may be a consequence of stable contacts that occur within capsomeres and flexible links that form among capsomeres.

Published
1996

7. Passive Immunization with a Single Monoclonal Neutralizing Antibody Protects against Cutaneous and Mucosal Mouse Papillomavirus Infections

Author

Brendle, Sarah A., primary, Li, Jingwei, additional, Cladel, Nancy M., additional, Balogh, Karla K., additional, Booth, Jennifer, additional, Shearer, Debra A., additional, Walter, Vonn, additional, Lu, Song, additional, Christensen, Neil D., additional, Covington, Danielle, additional, DeBroff, Jake, additional, Milici, Janice, additional, Zhu, Yusheng, additional, Viscidi, Raphael, additional, and Hu, Jiafen, additional

Published
2022
Full Text
View/download PDF

10. Mouse Papillomavirus L1 and L2 Are Dispensable for Viral Infection and Persistence at Both Cutaneous and Mucosal Tissues

Author

Brendle, Sarah, primary, Li, Jingwei J., additional, Cladel, Nancy M., additional, Shearer, Debra A., additional, Budgeon, Lynn R., additional, Balogh, Karla K., additional, Atkins, Hannah, additional, Costa-Fujishima, Marina, additional, Lopez, Paul, additional, Christensen, Neil D., additional, Doorbar, John, additional, Murooka, Thomas T., additional, and Hu, Jiafen, additional

Published
2021
Full Text
View/download PDF

15. Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models

Author

Cladel, Nancy M., primary, Jiang, Pengfei, additional, Li, Jingwei J., additional, Peng, Xuwen, additional, Cooper, Timothy K., additional, Majerciak, Vladimir, additional, Balogh, Karla K., additional, Meyer, Thomas J., additional, Brendle, Sarah A., additional, Budgeon, Lynn R., additional, Shearer, Debra A., additional, Munden, Regina, additional, Cam, Maggie, additional, Vallur, Raghavan, additional, Christensen, Neil D., additional, Zheng, Zhi-Ming, additional, and Hu, Jiafen, additional

Published
2019
Full Text
View/download PDF

27. The Mouse Papillomavirus Infection Model.

Author

Hu, Jiafen, Cladel, Nancy M., Budgeon, Lynn R., Balogh, Karla K., and Christensen, Neil D.

Subjects
*PAPILLOMAVIRUSES, *MOUSE diseases, *ANIMAL disease models, *IMMUNE response, *DISEASE progression
Abstract

The mouse papillomavirus (MmuPV1) was first reported in 2011 and has since become a powerful research tool. Through collective efforts from different groups, significant progress has been made in the understanding of molecular, virological, and immunological mechanisms of MmuPV1 infections in both immunocompromised and immunocompetent hosts. This mouse papillomavirus provides, for the first time, the opportunity to study papillomavirus infections in the context of a small common laboratory animal for which abundant reagents are available and for which many strains exist. The model is a major step forward in the study of papillomavirus disease and pathology. In this review, we summarize studies using MmuPV1 over the past six years and share our perspectives on the value of this unique model system. Specifically, we discuss viral pathogenesis in cutaneous and mucosal tissues as well as in different mouse strains, immune responses to the virus, and local host-restricted factors that may be involved in MmuPV1 infections and associated disease progression. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results