1. Ann Phys Rehabil Med
- Author
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Mélanie Cogné, Pierre-Alain Joseph, Hélène Cassoudesalle, Bénédicte Bullier, Bertrand Glize, Clémence Mollo, Igor Sibon, Isabelle de Gabory, Marie Villain, Patrick Dehail, CCSD, Accord Elsevier, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL), CHU Pontchaillou [Rennes], Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), and Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Adult ,Male ,Quality of life ,HACS ,030506 rehabilitation ,medicine.medical_specialty ,Population ,Affect (psychology) ,behavioral disciplines and activities ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Aphasia ,Sickness Impact Profile ,Activities of Daily Living ,medicine ,Humans ,Orthopedics and Sports Medicine ,In patient ,education ,Socioeconomic status ,Stroke ,Fatigue ,Aged ,Retrospective Studies ,education.field_of_study ,business.industry ,Depression ,Communication ,Rehabilitation ,Middle Aged ,medicine.disease ,Mood disorders ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Physical therapy ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,medicine.symptom ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
International audience; Background Aphasia severity is known to affect quality of life (QoL) in stroke patients, as is mood disorders, functional limitations, limitations on activities of daily life, economic status and level of education. However, communication limitation or fatigue has not been explored in this specific population. Objective We aimed to investigate whether these factors were associated with QoL in patients with aphasia after stroke. Methods Patients with aphasia were included from April 2014 to November 2017 after a first stroke and were followed for 2 years post-stroke. QoL was assessed at follow-up by the French Sickness Impact Profile 65 (SIP-65). We explored predictors such as mood disorders, communication impairment, fatigue, limitations on activities of daily life, and aphasia severity in addition to socio-demographic factors. Results We included 32 individuals (22 men; mean age 60.7 [SD 16.6] years) with aphasia after a first stroke. Poor QoL as assessed by the SIP-65 was significantly associated (Pearson correlations) with increased severity of aphasia initially (P = 0.008) and at follow-up (P = 0.01); increased communication activity limitations at follow-up (P < 0.001); increased limitations on activities of daily life at baseline (P = 0.008) and follow-up (P < 0.001); increased fatigue at follow-up (P = 0.001); and increased depression symptoms at follow-up (P = 0.001). On multivariable analysis, QoL was associated with communication activity limitations, limitations on activities of daily life, fatigue and depression, explaining more than 75% of the variance (linear regression R2 = 0.756, P < 0.001). The relative importance in predicting the variance was 32% for limitations on activities of daily life, 21% fatigue, 23% depression and 24% communication activity limitations. Conclusion Aphasia severity, mood disorders and functional limitations may have a negative effect on QoL in patients with aphasia. Also, for the first time, we show that fatigue has an important impact on QoL in this population. Specific management of this symptom might be beneficial and should be explored in future studies.
- Published
- 2020
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