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272 results on '"Cisteró, Pau"'

1. Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique.

Author

Brokhattingen, Nanna, Matambisso, Glória, da Silva, Clemente, Neubauer Vickers, Eric, Pujol, Arnau, Mbeve, Henriques, Cisteró, Pau, Maculuve, Sónia, Cuna, Boaventura, Melembe, Cardoso, Ndimande, Nelo, Palmer, Brian, García-Ulloa, Manuel, Munguambe, Humberto, Montaña-Lopez, Júlia, Nhamussua, Lidia, Simone, Wilson, Chidimatembue, Arlindo, Galatas, Beatriz, Guinovart, Caterina, Rovira-Vallbona, Eduard, Saúte, Francisco, Aide, Pedro, Aranda-Díaz, Andrés, Macete, Eusébio, Mayor, Alfredo, and Greenhouse, Bryan

Subjects
Child, Animals, Female, Pregnancy, Humans, Prenatal Care, Mozambique, Malaria, Plasmodium falciparum, Parasites, Genomics, Malaria, Falciparum
Abstract

Routine sampling of pregnant women at first antenatal care (ANC) visits could make Plasmodium falciparum genomic surveillance more cost-efficient and convenient in sub-Saharan Africa. We compare the genetic structure of parasite populations sampled from 289 first ANC users and 93 children from the community in Mozambique between 2015 and 2019. Samples are amplicon sequenced targeting 165 microhaplotypes and 15 drug resistance genes. Metrics of genetic diversity and relatedness, as well as the prevalence of drug resistance markers, are consistent between the two populations. In an area targeted for elimination, intra-host genetic diversity declines in both populations (p = 0.002-0.007), while for the ANC population, population genetic diversity is also lower (p = 0.0004), and genetic relatedness between infections is higher (p = 0.002) than control areas, indicating a recent reduction in the parasite population size. These results highlight the added value of genomic surveillance at ANC clinics to inform about changes in transmission beyond epidemiological data.

Published
2024

2. Targeted and whole-genome sequencing reveal a north-south divide in P. falciparum drug resistance markers and genetic structure in Mozambique.

Author

da Silva, Clemente, Boene, Simone, Datta, Debayan, Rovira-Vallbona, Eduard, Aranda-Díaz, Andrés, Cisteró, Pau, Hathaway, Nicholas, Tessema, Sofonias, Chidimatembue, Arlindo, Matambisso, Glória, Nhama, Abel, Macete, Eusebio, Pujol, Arnau, Nhamussua, Lidia, Galatas, Beatriz, Guinovart, Caterina, Enosse, Sónia, De Carvalho, Eva, Rogier, Eric, Plucinski, Mateusz M, Colborn, James, Zulliger, Rose, Saifodine, Abuchahama, Alonso, Pedro L, Candrinho, Baltazar, Greenhouse, Bryan, Aide, Pedro, Saute, Francisco, and Mayor, Alfredo

Subjects
Humans, Plasmodium falciparum, Malaria, Malaria, Falciparum, Antimalarials, Drug Resistance, Genetic Structures, Mozambique, Whole Genome Sequencing, Genetics, Vector-Borne Diseases, Rare Diseases, Infectious Diseases, Human Genome, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being
Abstract

Mozambique is one of the four African countries which account for over half of all malaria deaths worldwide, yet little is known about the parasite genetic structure in that country. We performed P. falciparum amplicon and whole genome sequencing on 2251 malaria-infected blood samples collected in 2015 and 2018 in seven provinces of Mozambique to genotype antimalarial resistance markers and interrogate parasite population structure using genome-wide microhaplotyes. Here we show that the only resistance-associated markers observed at frequencies above 5% were pfmdr1-184F (59%), pfdhfr-51I/59 R/108 N (99%) and pfdhps-437G/540E (89%). The frequency of pfdhfr/pfdhps quintuple mutants associated with sulfadoxine-pyrimethamine resistance increased from 80% in 2015 to 89% in 2018 (p

Published
2023

3. Sustained clinical benefit of malaria chemoprevention with sulfadoxine-pyrimethamine (SP) in pregnant women in a region with high SP resistance markers

Author

Matambisso, Glória, Brokhattingen, Nanna, Maculuve, Sónia, Cístero, Pau, Mbeve, Henriques, Escoda, Anna, Bambo, Gizela, Cuna, Boaventura, Melembe, Cardoso, Ndimande, Nelo, Tetteh, Kevin K.A., Drakeley, Chris, Gamain, Benoit, Chitnis, Chetan, Chauhan, Virander, Quintó, Llorenç, Macete, Eusébio, and Mayor, Alfredo

Published
2024
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4. Detecting temporal and spatial malaria patterns from first antenatal care visits

Author

Pujol, Arnau, Brokhattingen, Nanna, Matambisso, Glória, Mbeve, Henriques, Cisteró, Pau, Escoda, Anna, Maculuve, Sónia, Cuna, Boaventura, Melembe, Cardoso, Ndimande, Nelo, Munguambe, Humberto, Montaña, Júlia, Nhamússua, Lídia, Simone, Wilson, Tetteh, Kevin K. A., Drakeley, Chris, Gamain, Benoit, Chitnis, Chetan E., Chauhan, Virander, Quintó, Llorenç, Chidimatembue, Arlindo, Martí-Soler, Helena, Galatas, Beatriz, Guinovart, Caterina, Saúte, Francisco, Aide, Pedro, Macete, Eusébio, and Mayor, Alfredo

Published
2023
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5. Gravidity and malaria trends interact to modify P. falciparum densities and detectability in pregnancy: a 3-year prospective multi-site observational study

Author

Matambisso, Glória, Brokhattingen, Nanna, Maculuve, Sónia, Cisteró, Pau, Mbeve, Henriques, Escoda, Anna, Miguel, Judice, Buetas, Elena, de Jong, Ianthe, Cuna, Boaventura, Melembe, Cardoso, Ndimande, Nelo, Porras, Gemma, Chen, Haily, Tetteh, Kevin K. A., Drakeley, Chris, Gamain, Benoit, Chitnis, Chetan, Chauhan, Virander, Quintó, Llorenç, Galatas, Beatriz, Macete, Eusébio, and Mayor, Alfredo

Published
2022
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10. Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital

Author

Garcia-Basteiro, Alberto L., Moncunill, Gemma, Tortajada, Marta, Vidal, Marta, Guinovart, Caterina, Jiménez, Alfons, Santano, Rebeca, Sanz, Sergi, Méndez, Susana, Llupià, Anna, Aguilar, Ruth, Alonso, Selena, Barrios, Diana, Carolis, Carlo, Cisteró, Pau, Chóliz, Eugenia, Cruz, Angeline, Fochs, Silvia, Jairoce, Chenjerai, Hecht, Jochen, Lamoglia, Montserrat, Martínez, Mikel J., Mitchell, Robert A., Ortega, Natalia, Pey, Nuria, Puyol, Laura, Ribes, Marta, Rosell, Neus, Sotomayor, Patricia, Torres, Sara, Williams, Sarah, Barroso, Sonia, Vilella, Anna, Muñoz, José, Trilla, Antoni, Varela, Pilar, Mayor, Alfredo, and Dobaño, Carlota

Published
2020
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12. Detecting temporal and spatial malaria patterns from first antenatal care visits

Author

Pujol, Arnau, primary, Brokhattingen, Nanna, additional, Matambisso, Gloria, additional, Mbeve, Henriques, additional, Cisteró, Pau, additional, Escoda, Anna, additional, Maculuve, Sonia, additional, Cuna, Boaventura, additional, Melembe, Cardoso, additional, Ndimande, Nelo, additional, Munguambe, Humberto, additional, Lopez, Julia Montana, additional, Nhamussa, Lidia, additional, Simone, Wilson, additional, Tetteh, Kevin, additional, Drakeley, Chris, additional, Gamain, Benoît, additional, Chitnis, Chetan, additional, Chauhan, Virander Singh, additional, Quintó, Llorenç, additional, Chidimatembue, Arlindo, additional, Soler, Helena Martí, additional, Galatas, Beatriz, additional, Guinovart, Caterina, additional, Saute, Francisco, additional, Aide, Pedro, additional, Macete, Eusebio, additional, and Mayor, Alfredo, additional

Published
2023
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15. Genetic Signals Of Reduced Plasmodium Falciparum Transmission after an Elimination Program in Mozambique: A Genomic Surveillance Study of Antenatal Care Users and Children

Author

Brokhattingen, Nanna, primary, Matambisso, Gloria, additional, da Silva, Clemente, additional, Neubauer Vickers, Eric, additional, Pujol, Arnau, additional, Mbeve, Henriques, additional, Cisteró, Pau, additional, Maculuve, Sónia, additional, Cuna, Boaventura, additional, Melembe, Cardoso, additional, Ndimande, Nelo, additional, Palmer, Brian, additional, García Ulloa, Manuel, additional, Munguambe, Humberto, additional, Montana, Julia, additional, Nhamussua, Lidia, additional, Simone, Wilson, additional, Chidimatembue, Arlindo, additional, Galatas, Beatriz, additional, Guinovart, Caterina, additional, Rovira-Vallbona, Eduard, additional, Saute, Francisco, additional, Aide, Pedro, additional, Aranda-Díaz, Andrés, additional, Greenhouse, Bryan, additional, Macete, Eusébio, additional, and Mayor, Alfredo, additional

Published
2023
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18. Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia

Author

Martínez-Pérez, Guillermo, Lansana, Dawoh Peter, Omeonga, Senga, Gupta, Himanshu, Breeze-Barry, Bondey, González, Raquel, Bardají, Azucena, Sarukhan, Adelaida, Goteh, James D. K., Tody, Edith, Cisteró, Pau, Benda, Benard, Kercula, Juwe D., Kibungu, Fanta D., Meyer García-Sípido, Ana, Bassat, Quique, Tarr-Attia, Christine K., and Mayor, Alfredo

Published
2018
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25. Additional file 4 of Gravidity and malaria trends interact to modify P. falciparum densities and detectability in pregnancy: a 3-year prospective multi-site observational study

Author

Matambisso, Glória, Brokhattingen, Nanna, Maculuve, Sónia, Cisteró, Pau, Mbeve, Henriques, Escoda, Anna, Miguel, Judice, Buetas, Elena, de Jong, Ianthe, Cuna, Boaventura, Melembe, Cardoso, Ndimande, Nelo, Porras, Gemma, Chen, Haily, Tetteh, Kevin K. A., Drakeley, Chris, Gamain, Benoit, Chitnis, Chetan, Chauhan, Virander, Quintó, Llorenç, Galatas, Beatriz, Macete, Eusébio, and Mayor, Alfredo

Abstract

Additional file 4. Supplementary results (P. falciparum parasite densities).

Published
2022
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26. Additional file 2 of Gravidity and malaria trends interact to modify P. falciparum densities and detectability in pregnancy: a 3-year prospective multi-site observational study

Author

Matambisso, Glória, Brokhattingen, Nanna, Maculuve, Sónia, Cisteró, Pau, Mbeve, Henriques, Escoda, Anna, Miguel, Judice, Buetas, Elena, de Jong, Ianthe, Cuna, Boaventura, Melembe, Cardoso, Ndimande, Nelo, Porras, Gemma, Chen, Haily, Tetteh, Kevin K. A., Drakeley, Chris, Gamain, Benoit, Chitnis, Chetan, Chauhan, Virander, Quintó, Llorenç, Galatas, Beatriz, Macete, Eusébio, and Mayor, Alfredo

Abstract

Additional file 2. Supplementary methods (Quantitative suspension array assay).

Published
2022
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27. Additional file 1 of Gravidity and malaria trends interact to modify P. falciparum densities and detectability in pregnancy: a 3-year prospective multi-site observational study

Author

Matambisso, Glória, Brokhattingen, Nanna, Maculuve, Sónia, Cisteró, Pau, Mbeve, Henriques, Escoda, Anna, Miguel, Judice, Buetas, Elena, de Jong, Ianthe, Cuna, Boaventura, Melembe, Cardoso, Ndimande, Nelo, Porras, Gemma, Chen, Haily, Tetteh, Kevin K. A., Drakeley, Chris, Gamain, Benoit, Chitnis, Chetan, Chauhan, Virander, Quintó, Llorenç, Galatas, Beatriz, Macete, Eusébio, and Mayor, Alfredo

Abstract

Additional file 1: Fig. S1. Map of Manhiça and Magude District in southern Mozambique where the study was conducted. Fig. S2: Performance of the qPCRs and quantitative suspension array assays along with the different experiments. Fig. S3. Study profile. Fig. S4. Genetic complexity of the infections by study area and period. Fig. S5. Antibody levels by studied factors.

Published
2022
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28. Additional file 3 of Gravidity and malaria trends interact to modify P. falciparum densities and detectability in pregnancy: a 3-year prospective multi-site observational study

Author

Matambisso, Glória, Brokhattingen, Nanna, Maculuve, Sónia, Cisteró, Pau, Mbeve, Henriques, Escoda, Anna, Miguel, Judice, Buetas, Elena, de Jong, Ianthe, Cuna, Boaventura, Melembe, Cardoso, Ndimande, Nelo, Porras, Gemma, Chen, Haily, Tetteh, Kevin K. A., Drakeley, Chris, Gamain, Benoit, Chitnis, Chetan, Chauhan, Virander, Quintó, Llorenç, Galatas, Beatriz, Macete, Eusébio, and Mayor, Alfredo

Abstract

Additional file 3. Table S1. Characteristics of study participants. Table S2. Interactions between centers and study variables on parasitological outcomes. Table S3. Interactions between gravidity and temporal trends on parasitological outcomes. Table S4. P. falciparum parasite rates, density and detectability between centers. Table S5. Annual changes in parasitological outcomes in pregnant women from Ilha Josina. Table S6. Annual changes in antibody levels by site and gravidity group.

Published
2022
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29. IgG against Plasmodium falciparum variant surface antigens and growth inhibitory antibodies in Mozambican children receiving intermittent preventive treatment with sulfadoxine-pyrimethamine

Author

Quelhas, Diana, Jiménez, Alfons, Quintó, Llorenç, Serra-Casas, Elisa, Mayor, Alfredo, Cisteró, Pau, Puyol, Laura, Wilson, Danny W., Richards, Jack S., Nhampossa, Tacilta, Macete, Eusebio, Aide, Pedro, Mandomando, Inacio, Sanz, Sergi, Aponte, John J., Alonso, Pedro L., Beeson, James G., Menéndez, Clara, and Dobaño, Carlota

Published
2011
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30. P. Falciparum Densities and Detectability in Pregnancy During Declining Malaria: A Three-Year Prospective Multi-Site Observational Study

Author

Matambisso, Glória, primary, Brokhattingen, Nanna, additional, Maculuve, Sónia, additional, Cisteró, Pau, additional, Mbeve, Henriques, additional, Escoda, Anna, additional, Miguel, Judice, additional, Buetas, Elena, additional, de Jong, Ianthe, additional, Cuna, Boaventura, additional, Melembe, Cardoso, additional, Ndimande, Nelo, additional, Porras, Gemma, additional, Chen, Haily, additional, Tetteh, Kevin K.A., additional, Drakeley, Chris, additional, Gamain, Benoit, additional, Chitnis, Chetan, additional, Chauhan, Virander, additional, Quintó, Llorenç, additional, Galatas, Beatriz, additional, Macete, Eusébio, additional, and Mayor, Alfredo, additional

Published
2022
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31. Plasmodium falciparum and Helminth Coinfections Increase IgE and Parasite-Specific IgG Responses

Author

Santano, Rebeca, primary, Rubio, Rocío, additional, Grau-Pujol, Berta, additional, Escola, Valdemiro, additional, Muchisse, Osvaldo, additional, Cuamba, Inocência, additional, Vidal, Marta, additional, Cisteró, Pau, additional, Ruiz-Olalla, Gemma, additional, Aguilar, Ruth, additional, Demontis, Maria, additional, Jamine, Jose Carlos, additional, Cossa, Anélsio, additional, Sacoor, Charfudin, additional, Cano, Jorge, additional, Izquierdo, Luis, additional, Chitnis, Chetan E., additional, Coppel, Ross L., additional, Chauhan, Virander, additional, Cavanagh, David, additional, Dutta, Sheetij, additional, Angov, Evelina, additional, Gaur, Deepak, additional, van Lieshout, Lisette, additional, Zhan, Bin, additional, Muñoz, Jose, additional, Moncunill, Gemma, additional, and Dobaño, Carlota, additional

Published
2021
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32. Validity of a minimally invasive autopsy for cause of death determination in maternal deaths in Mozambique: An observational study

Author

Castillo, Paola, Hurtado, Juan Carlos, Martínez, Miguel J., Jordao, Dercio, Lovane, Lucilia, Ismail, Mamudo R., Carrilho, Carla, Lorenzoni, Cesaltina, Fernandes, Fabiola, Mocumbi, Sibone, Jaze, Zara Onila, Mabota, Flora, Cossa, Anelsio, Mandomando, Inacio, Cisteró, Pau, Mayor, Alfredo, Navarro, Mireia, Casas, Isaac, Vila, Jordi, Maixenchs, Maria, Munguambe, Khátia, Sanz, Ariadna, Quintó, Llorenç, Macete, Eusebio, Alonso, Pedro, Bassat, Quique, Ordi, Jaume, and Menéndez, Clara

Subjects
Maternal mortality -- Forecasts and trends, Preventive medicine -- Methods, Market trend/market analysis, Biological sciences
Abstract

Background Despite global health efforts to reduce maternal mortality, rates continue to be unacceptably high in large parts of the world. Feasible, acceptable, and accurate postmortem sampling methods could provide the necessary evidence to improve the understanding of the real causes of maternal mortality, guiding the design of interventions to reduce this burden. Methods and findings The validity of a minimally invasive autopsy (MIA) method in determining the cause of death was assessed in an observational study in 57 maternal deaths by comparing the results of the MIA with those of the gold standard (complete diagnostic autopsy [CDA], which includes any available clinical information). Concordance between the MIA and the gold standard diagnostic categories was assessed by the kappa statistic, and the sensitivity, specificity, positive and negative predictive values and their 95% confidence intervals (95% CI) to identify the categories of diagnoses were estimated. The main limitation of the study is that both the MIA and the CDA include some degree of subjective interpretation in the attribution of cause of death. A cause of death was identified in the CDA in 98% (56/57) of cases, with indirect obstetric conditions accounting for 32 (56%) deaths and direct obstetric complications for 24 (42%) deaths. Nonobstetric infectious diseases (22/32, 69%) and obstetric hemorrhage (13/24, 54%) were the most common causes of death among indirect and direct obstetric conditions, respectively. Thirty-six (63%) women were HIV positive, and HIV-related conditions accounted for 16 (28%) of all deaths. Cerebral malaria caused 4 (7%) deaths. The MIA identified a cause of death in 86% of women. The overall concordance of the MIA with the CDA was moderate (kappa = 0.48, 95% CI: 0.31-0.66). Both methods agreed in 68% of the diagnostic categories and the agreement was higher for indirect (91%) than for direct obstetric causes (38%). All HIV infections and cerebral malaria cases were identified in the MIA. The main limitation of the technique is its relatively low performance for identifying obstetric causes of death in the absence of clinical information. Conclusions The MIA procedure could be a valuable tool to determine the causes of maternal death, especially for indirect obstetric conditions, most of which are infectious diseases. The information provided by the MIA could help to prioritize interventions to reduce maternal mortality and to monitor progress towards achieving global health targets., Author(s): Paola Castillo 1,2, Juan Carlos Hurtado 1,3, Miguel J. Martínez 1,3, Dercio Jordao 4, Lucilia Lovane 4, Mamudo R. Ismail 4,5, Carla Carrilho 4,5, Cesaltina Lorenzoni 4,5, Fabiola Fernandes [...]

Published
2017
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33. Changing Trends in P. falciparum Burden, Immunity, and Disease in Pregnancy

Author

Mayor, Alfredo, Bardají, Azucena, Macete, Eusebio, Nhampossa, Tacilta, Fonseca, Ana Maria, González, Raquel, Maculuve, Sonia, Cisteró, Pau, Rupérez, Maria, Campo, Joe, Vala, Anifa, Sigaúque, Betuel, Jiménez, Alfons, Machevo, Sonia, de la Fuente, Laura, Nhama, Abel, Luis, Leopoldina, Aponte, John J., Acácio, Sozinho, Nhacolo, Arsenio, Chitnis, Chetan, Dobaño, Carlota, Sevene, Esperanza, Alonso, Pedro Luis, and Menéndez, Clara

Published
2015
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34. Accuracy of verbal autopsy, clinical data and minimally invasive autopsy in the evaluation of malaria-specific mortality: an observational study

Author

Rakislova, Natalia, primary, Jordao, Dercio, additional, Ismail, Mamudo R, additional, Mayor, Alfredo, additional, Cisteró, Pau, additional, Marimon, Lorena, additional, Ferrando, Melania, additional, Hurtado, Juan Carlos, additional, Lovane, Lucilia, additional, Carrilho, Carla, additional, Lorenzoni, Cesaltina, additional, Fernandes, Fabiola, additional, Nhampossa, Tacilta, additional, Cossa, Anelsio, additional, Mandomando, Inacio, additional, Navarro, Mireia, additional, Casas, Isaac, additional, Munguambe, Khatia, additional, Maixenchs, Maria, additional, Quintó, Llorenç, additional, Macete, Eusebio, additional, Martinez, Mikel, additional, Snow, Robert W, additional, Bassat, Quique, additional, Menéndez, Clara, additional, and Ordi, Jaume, additional

Published
2021
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35. Plasmodium falciparumand helminth coinfections increase IgE and parasite-specific IgG responses

Author

Santano, Rebeca, primary, Rubio, Rocío, additional, Grau-Pujol, Berta, additional, Escola, Valdemiro, additional, Muchisse, Osvaldo, additional, Cuamba, Inocência, additional, Vidal, Marta, additional, Cisteró, Pau, additional, Ruiz-Olalla, Gemma, additional, Aguilar, Ruth, additional, Demontis, Maria, additional, Jamine, Jose Carlos, additional, Cossa, Anélsio, additional, Sacoor, Charfudin, additional, Cano, Jorge, additional, Izquierdo, Luis, additional, Chitnis, Chetan E, additional, Coppel, Ross L, additional, Chauhan, Virander, additional, Cavanagh, David, additional, Dutta, Sheetij, additional, Angov, Evelina, additional, Gaur, Deepak, additional, van Lieshout, Lisette, additional, Zhan, Bin, additional, Muñoz, José, additional, Moncunill, Gemma, additional, and Dobaño, Carlota, additional

Published
2021
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36. The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

Author

López, Mariana G., Chiner-Oms, Álvaro, García de Viedma, Darío, Ruiz-Rodriguez, Paula, Bracho, Maria Alma, Cancino-Muñoz, Irving, D’Auria, Giuseppe, de Marco, Griselda, García-González, Neris, Goig, Galo Adrian, Gómez-Navarro, Inmaculada, Jiménez-Serrano, Santiago, Martinez-Priego, Llúcia, Ruiz-Hueso, Paula, Ruiz-Roldán, Lidia, Torres-Puente, Manuela, Alberola, Juan, Albert, Eliseo, Aranzamendi Zaldumbide, Maitane, Bea-Escudero, María Pilar, Boga, Jose Antonio, Bordoy, Antoni E., Canut-Blasco, Andrés, Carvajal, Ana, Cilla Eguiluz, Gustavo, Cordón Rodríguez, Maria Luz, Costa-Alcalde, José J., de Toro, María, de Toro Peinado, Inmaculada, del Pozo, Jose Luis, Duchêne, Sebastián, Fernández-Pinero, Jovita, Fuster Escrivá, Begoña, Gimeno Cardona, Concepción, González Galán, Verónica, Gonzalo Jiménez, Nieves, Hernáez Crespo, Silvia, Herranz, Marta, Lepe, José Antonio, López-Causapé, Carla, López-Hontangas, José Luis, Martín, Vicente, Martró, Elisa, Milagro Beamonte, Ana, Montes Ros, Milagrosa, Moreno-Muñoz, Rosario, Navarro, David, Navarro-Marí, José María, Not, Anna, Oliver, Antonio, Palop-Borrás, Begoña, Parra Grande, Mónica, Pedrosa-Corral, Irene, Pérez González, Maria Carmen, Pérez-Lago, Laura, Pérez-Ruiz, Mercedes, Piñeiro Vázquez, Luis, Rabella, Nuria, Rezusta, Antonio, Robles Fonseca, Lorena, Rodríguez-Villodres, Ángel, Sanbonmatsu-Gámez, Sara, Sicilia, Jon, Soriano, Alex, Tirado Balaguer, María Dolores, Torres, Ignacio, Tristancho, Alexander, Marimón, José María, Pérez-Tur, Jordi, Catalán-Alonso, Pilar, Suárez González, Julia, Muñoz, Patricia, Ruiz-Rodríguez, Paula, Bracho, María Alma, Martínez Priego, Llúcia, Galán-Vendrell, Inmaculada, De Marco, Griselda, Ferrús-Abad, María Loreto, Carbó-Ramírez, Sandra, Nogueira, Jose Miguel, Camarena, Juan José, Martínez Expósito, Óscar, Antona Urieta, Nerea, Castelló-Abietar, Cristian, Rojo-Alba, Susana, Álvarez-Argüelles, Marta Elena, Melón, Santiago, Antuori, Adrián, Fernández-Navarro, Anabel, Lecaroz Agara, Maria Concepción, Gómez-González, Carmen, Aguirre-Quiñonero, Amaia, López-Mirones, José Israel, Fernández-Torres, Marina, Almela-Ferrer, Maria Rosario, Fregeneda-Grandes, Juan Miguel, Argüello, Héctor, Sorarrain, Ane, Trastoy, Rocío, Barbeito Castiñeiras, Gema, Coira, Amparo, Pérez del Molino, María Luisa, Aguilera, Antonio, Mediavilla Gradolph, Maria Concepción, Fernández-Alonso, Mirian, González-Recio, Oscar, Gutiérrez-Rivas, Mónica, Jiménez Clavero, Miguel Ángel, Ocete Mochón, María Dolores, Medina-Gonzalez, Rafael, Reina, Jordi, Gómez-Ruiz, Maria Dolores, Gonzalez-Barbera, Eva M., Molina, Antonio J., Fernandez-Villa, Tania, Martínez-Cameo, Nieves Felisa, Gracia-Grataloup, Yolanda, Tirado Balaguer, Maria Dolores, Gómez Alonso, Bárbara, Arjona Zaragozí, Francisco José, Chamizo López, Francisco Javier, Bordes-Benítez, Ana, Rabella, Núria, Navarro, Ferran, Miró, Elisenda, Simarro Córdoba, Encarnación, Lozano-Serra, Julia, Soriano, Álex, Roig Sena, Francisco Javier, Vanaclocha Luna, Hermelinda, Sanmartín, Isabel, García-Souto, Daniel, Pequeño-Valtierra, Ana, Tubio, Jose M. C., Temes, Javier, Rodríguez-Castro, Jorge, Santamarina García, Martín, Rodríguez-Iglesias, Manuel, Galán-Sanchez, Fátima, Rodríguez-Pallares, Salud, Azcona-Gutiérrez, José Manuel, Blasco-Alberdi, Miriam, Mayor, Alfredo, García-Basteiro, Alberto L., Moncunill, Gemma, Dobaño, Carlota, Cisteró, Pau, Mitjà, Oriol, González-Beiras, Camila, Vall-Mayans, Martí, Corbacho-Monné, Marc, Alemany, Andrea, Muñoz-Cuevas, Cristina, Rodríguez-Rodríguez, Guadalupe, Benito, Rafael, Algarate, Sonia, Bueno, Jessica, Vergara-Gómez, Andrea, Martínez, Miguel J., Vila, Jordi, Rubio, Elisa, Peiró-Mestres, Aida, Navero-Castillejos, Jessica, Posada, David, Valverde, Diana, Estévez, Nuria, Fernández-Silva, Iria, de Chiara, Loretta, Gallego-García, Pilar, Varela, Nair, Gómez-Pinedo, Ulises, Gozalo-Margüello, Mónica, Cano García, Maria Eliecer, Méndez-Legaza, José Manuel, Rodríguez-Lozano, Jesus, Siller, María, Pablo-Marcos, Daniel, Ruiz-García, Maria Montserrat, Galiana, Antonio, Sánchez-Almendro, Judith, Gascón Ros, Maria Isabel, Torregrosa-Hetland, Cristina Juana, Pastor Boix, Eva María, Cascales Ramos, Paloma, Garcinuño Enríquez, Pedro Luis, Raga Borja, Salvador, González Cantó, Julia, Martínez Macias, Olalla, de Salazar, Adolfo, Viñuela González, Laura, Chueca, Natalia, García, Federico, Gómez-Camarasa, Cristina, Farga Martí, Amparo, Falcón, Rocío, Domínguez-Márquez, Victoria, Planas, Anna M., Fernández-Cádenas, Israel, Marcos, Maria Ángeles, Ezpeleta, Carmen, Navascués, Ana, Miqueleiz Zapatero, Ana, Segovia, Manuel, Moreno-Docón, Antonio, Viedma, Esther, Recio Martínez, Raúl, Muñoz-Gallego, Irene, Gonzalez-Bodi, Sara, Folgueira, Maria Dolores, Mingorance, Jesús, Dahdouh, Elias, Lázaro-Perona, Fernando, Rodríguez-Tejedor, María, Romero-Gómez, María Pilar, García-Rodríguez, Julio, Galán, Juan Carlos, Rodríguez-Dominguez, Mario, Martínez-García, Laura, Abreu Di Berardino, Melanie, Ponce-Alonso, Manuel, González-Alba, Jose Maria, Sanz-Muñoz, Ivan, Pérez San José, Diana, Gil Fortuño, Maria, Bellido-Blasco, Juan B., Yagüe Muñoz, Alberto, Hernández Pérez, Noelia, Buj Jordá, Helena, Pérez Olaso, Óscar, González Praetorius, Alejandro, Martínez Ramírez, Nora Mariela, Ramírez Marinero, Aida, Padilla León, Eduardo, Vilas Basil, Alba, Canal Aranda, Mireia, Bernet Sánchez, Albert, Bellés Bellés, Alba, López González, Eric, Prats Sánchez, Iván, García-González, Mercè, Martínez-Lirola, Miguel José, Rodríguez Maresca, Manuel Ángel, Cabezas Fernández, Maria Teresa, Carrillo Gil, María Eugenia, Ventero Martín, Maria Paz, Molina Pardines, Carmen, Orta Mira, Nieves, Navarro Cots, María, Vidal Catalá, Inmaculada, García Nava, Isabel, Illescas Fernández-Bermejo, Soledad, Martínez-Alarcón, José, Torres-Narbona, Marta, Colmenarejo, Cristina, García-Agudo, Lidia, Pérez García, Jorge A., Yago López, Martín, Goberna Bravo, María Ángeles, Simón García, Victoria, Llop Furquet, Gonzalo, Iranzo Tatay, Agustín, Moreno-Marro, Sandra, Lozano Rodríguez, Noelia, Broseta Tamarit, Amparo, Badiola Díez, Juan José, Martínez-Ramírez, Amparo, Dopazo, Ana, Callejas, Sergio, Benguría, Alberto, Aguado, Begoña, Alcamí, Antonio, Bermejo Bermejo, Marta, Ramos-Ruíz, Ricardo, Fernández Soria, Víctor Manuel, Simón Soria, Fernando, Roig Cardells, Mercedes, Coscolla, Mireia, González-Candelas, Fernando, Comas, Iñaki, Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Research Council, European Commission, Generalitat Valenciana, Chiner-Oms, Álvaro [0000-0002-0463-0101], Ruiz-Rodríguez, Paula [0000-0003-0727-5974], D'Auria, Giuseppe [0000-0003-0672-2541], Gómez-Navarro, Inmaculada [0000-0002-5235-7365], Jiménez Serrano, Santiago [0000-0003-2917-6053], Aranzamendi Zaldumbide, Maitane [0000-0003-2432-7078], Boga, José Antonio [0000-0002-5500-9972], Bordoy, Antoni E. [0000-0002-1165-542X], Costa-Alcalde, José J. [0000-0002-1916-2216], Toro Peinado, Inmaculada de [0000-0002-8151-3275], López-Causapé, Carla [0000-0003-2228-2005], Martín, Vicente [0000-0003-0552-2804], Moreno-Muñoz, Rosario [0000-0002-0185-5612], Parra Grande, Mónica [0000-0002-8330-7467], Balaguer, María Dolores [0000-0003-3808-7300], Coscolla, Mireia [0000-0003-0752-0538], González-Candelas, Fernando [0000-0002-0879-5798], Comas, Iñaki [0000-0001-5504-9408], Ministerio de Ciencia (España), Generalitat Valenciana (España), Chiner-Oms, Álvaro, Ruiz-Rodríguez, Paula, D'Auria, Giuseppe, Gómez-Navarro, Inmaculada, Jiménez Serrano, Santiago, Aranzamendi Zaldumbide, Maitane, Boga, José Antonio, Bordoy, Antoni E., Costa-Alcalde, José J., Toro Peinado, Inmaculada de, López-Causapé, Carla, Martín, Vicente, Moreno-Muñoz, Rosario, Parra Grande, Mónica, Balaguer, María Dolores, Coscolla, Mireia, González-Candelas, Fernando, Comas, Iñaki, and Marimon, Jose Maria

Subjects
DYNAMICS, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Physical Distancing, Biology, Severity of Illness Index, Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Pandemic, Quarantine, Genetics, Humans, Clade, Phylogeny, 030304 developmental biology, 0303 health sciences, Models, Statistical, SARS-CoV-2, Incidence (epidemiology), Incidence, Genetic variants, COVID-19, Genomics, New variant, Dynamics, Virus, 3. Good health, Spain, Communicable Disease Control, VIRUS, 030217 neurology & neurosurgery, Demography
Abstract

SeqCOVID-Spain consortium: Álvaro Chiner-Oms, Irving Cancino-Muñoz, Mariana G. López, Manuela Torres-Puente, Inmaculada Gómez-Navarro, Santiago Jiménez-Serrano, Jordi Pérez-Tur, Darío García de Viedma, Laura Pérez-Lago, Marta Herranz, Jon Sicilia, Pilar Catalán-Alonso, Julia Suárez González, Patricia Muñoz, Mireia Coscolla, Paula Ruiz-Rodríguez, Fernando González-Candelas, Iñaki Comas, Lidia Ruiz-Roldán, María Alma Bracho, Neris García-González, Llúcia Martínez Priego, Inmaculada Galán-Vendrell, Paula Ruiz-Hueso, Griselda De Marco, María Loreto Ferrús-Abad, Sandra Carbó-Ramírez, Giuseppe D’Auria, Galo Adrian Goig, Juan Alberola, Jose Miguel Nogueira, Juan José Camarena, David Navarro, Eliseo Albert, Ignacio Torres, Maitane Aranzamendi Zaldumbide, Óscar Martínez Expósito, Nerea Antona Urieta, María de Toro, María Pilar Bea-Escudero, Jose Antonio Boga, Cristian Castelló-Abietar, Susana Rojo-Alba, Marta Elena Álvarez-Argüelles, Santiago Melón, Elisa Martró, Antoni E. Bordoy, Anna Not, Adrián Antuori, Anabel Fernández-Navarro, Andrés Canut-Blasco, Silvia Hernáez Crespo, Maria Luz Cordón Rodríguez, Maria Concepción Lecaroz Agara, Carmen Gómez-González, Amaia Aguirre-Quiñonero, José Israel López-Mirones, Marina Fernández-Torres, Maria Rosario Almela-Ferrer, Ana Carvajal, Juan Miguel Fregeneda-Grandes, Héctor Argüello, Gustavo Cilla Eguiluz, Milagrosa Montes Ros, Luis Piñeiro Vázquez, Ane Sorarrain, José María Marimón, José J. Costa-Alcalde, Rocío Trastoy, Gema Barbeito Castiñeiras, Amparo Coira, María Luisa Pérez del Molino, Antonio Aguilera, Begoña Palop-Borrás, Inmaculada de Toro Peinado, Maria Concepción Mediavilla Gradolph, Mercedes Pérez-Ruiz, Mirian Fernández-Alonso, Jose Luis del Pozo, Oscar González-Recio, Mónica Gutiérrez-Rivas, Jovita Fernández-Pinero, Miguel Ángel Jiménez Clavero, Begoña Fuster Escrivá, Concepción Gimeno Cardona, María Dolores Ocete Mochón, Rafael Medina-Gonzalez, José Antonio Lepe, Verónica González Galán, Ángel Rodríguez-Villodres, Nieves Gonzalo Jiménez, Jordi Reina, Carla López-Causapé, Maria Dolores Gómez-Ruiz, Eva M. Gonzalez-Barbera, José Luis López-Hontangas, Vicente Martín, Antonio J. Molina, Tania Fernandez-Villa, Ana Milagro Beamonte, Nieves Felisa Martínez-Cameo, Yolanda Gracia-Grataloup, Rosario Moreno-Muñoz, Maria Dolores Tirado Balaguer, José María Navarro-Marí, Irene Pedrosa-Corral, Sara Sanbonmatsu-Gámez, Antonio Oliver, Mónica Parra Grande, Bárbara Gómez Alonso, Francisco José Arjona Zaragozí, Maria Carmen Pérez González, Francisco Javier Chamizo López, Ana Bordes-Benítez, Núria Rabella, Ferran Navarro, Elisenda Miró, Antonio Rezusta, Alexander Tristancho, Encarnación Simarro Córdoba, Julia Lozano-Serra, Lorena Robles Fonseca, Álex Soriano, Francisco Javier Roig Sena, Hermelinda Vanaclocha Luna, Isabel Sanmartín, Daniel García-Souto, Ana Pequeño-Valtierra, Jose M. C. Tubio, Javier Temes, Jorge Rodríguez-Castro, Martín Santamarina García, Manuel Rodríguez-Iglesias, Fátima Galán-Sanchez, Salud Rodríguez-Pallares, José Manuel Azcona-Gutiérrez, Miriam Blasco-Alberdi, Alfredo Mayor, Alberto L. García-Basteiro, Gemma Moncunill, Carlota Dobaño, Pau Cisteró, Oriol Mitjà, Camila González-Beiras, Martí Vall-Mayans, Marc Corbacho-Monné, Andrea Alemany, Cristina Muñoz-Cuevas, Guadalupe Rodríguez-Rodríguez, Rafael Benito, Sonia Algarate, Jessica Bueno, Andrea Vergara-Gómez, Miguel J. Martínez, Jordi Vila, Elisa Rubio, Aida Peiró-Mestres, Jessica Navero-Castillejos, David Posada, Diana Valverde, Nuria Estévez, Iria Fernández-Silva, Loretta de Chiara, Pilar Gallego-García, Nair Varela, Ulises Gómez-Pinedo, Mónica Gozalo-Margüello, Maria Eliecer Cano García, José Manuel Méndez-Legaza, Jesus Rodríguez-Lozano, María Siller, Daniel Pablo-Marcos, Maria Montserrat Ruiz-García, Antonio Galiana, Judith Sánchez-Almendro, Maria Isabel Gascón Ros, Cristina Juana Torregrosa-Hetland, Eva María Pastor Boix, Paloma Cascales Ramos, Pedro Luis Garcinuño Enríquez, Salvador Raga Borja, Julia González Cantó, Olalla Martínez Macias, Adolfo de Salazar, Laura Viñuela González, Natalia Chueca, Federico García, Cristina Gómez-Camarasa, Amparo Farga Martí, Rocío Falcón, Victoria Domínguez-Márquez, Anna M. Planas, Israel Fernández-Cádenas, Maria Ángeles Marcos, Carmen Ezpeleta, Ana Navascués, Ana Miqueleiz Zapatero, Manuel Segovia, Antonio Moreno-Docón, Esther Viedma, Raúl Recio Martínez, Irene Muñoz-Gallego, Sara Gonzalez-Bodi, Maria Dolores Folgueira, Jesús Mingorance, Elias Dahdouh, Fernando Lázaro-Perona, María Rodríguez-Tejedor, María Pilar Romero-Gómez, Julio García-Rodríguez, Juan Carlos Galán, Mario Rodríguez-Dominguez, Laura Martínez-García, Melanie Abreu Di Berardino, Manuel Ponce-Alonso, Jose Maria González-Alba, Ivan Sanz-Muñoz, Diana Pérez San José, Maria Gil Fortuño, Juan B. Bellido-Blasco, Alberto Yagüe Muñoz, Noelia Hernández Pérez, Helena Buj Jordá, Óscar Pérez Olaso, Alejandro González Praetorius, Nora Mariela Martínez Ramírez, Aida Ramírez Marinero, Eduardo Padilla León, Alba Vilas Basil, Mireia Canal Aranda, Albert Bernet Sánchez, Alba Bellés Bellés, Eric López González, Iván Prats Sánchez, Mercè García-González, Miguel José Martínez-Lirola, Manuel Ángel Rodríguez Maresca, Maria Teresa Cabezas Fernández, María Eugenia Carrillo Gil, Maria Paz Ventero Martín, Carmen Molina Pardines, Nieves Orta Mira, María Navarro Cots, Inmaculada Vidal Catalá, Isabel García Nava, Soledad Illescas Fernández-Bermejo, José Martínez-Alarcón, Marta Torres-Narbona, Cristina Colmenarejo, Lidia García-Agudo, Jorge A. Pérez García, Martín Yago López, María Ángeles Goberna Bravo, Victoria Simón García, Gonzalo Llop Furquet, Agustín Iranzo Tatay, Sandra Moreno-Marro, Noelia Lozano Rodríguez, Amparo Broseta Tamarit, Juan José Badiola Díez, Amparo Martínez-Ramírez, Ana Dopazo, Sergio Callejas, Alberto Benguría, Begoña Aguado, Antonio Alcamí, Marta Bermejo Bermejo, Ricardo Ramos-Ruíz, Víctor Manuel Fernández Soria, Fernando Simón Soria & Mercedes Roig Cardells, The coronavirus disease 2019 (COVID-19) pandemic has affected the world radically since 2020. Spain was one of the European countries with the highest incidence during the first wave. As a part of a consortium to monitor and study the evolution of the epidemic, we sequenced 2,170 samples, diagnosed mostly before lockdown measures. Here, we identified at least 500 introductions from multiple international sources and documented the early rise of two dominant Spanish epidemic clades (SECs), probably amplified by superspreading events. Both SECs were related closely to the initial Asian variants of SARS-CoV-2 and spread widely across Spain. We inferred a substantial reduction in the effective reproductive number of both SECs due to public-health interventions (Re, This work was mainly funded by the Instituto de Salud Carlos III project COV20/00140, with additional funding by Spanish National Research Council project CSIC-COV19-021, Ministerio de Ciencia project PID2019-104477RB-100, ERC StG 638553 and ERC CoG 101001038 to I.C., and BFU2017-89594R to F.G.C. M.C. is supported by Ramón y Cajal program from Ministerio de Ciencia and grants RTI2018-094399-A-I00 and Generalitat Valenciana (Regional Government) project SEJI/2019/011. We gratefully acknowledge Hospital Universitari Vall d’Hebron, Instituto de Salud Carlos III, IrsiCaixa AIDS Research Lab and all the international researchers and institutions that submitted sequenced SARS-CoV-2 genomes to the GISAID’s EpiCov Database (Supplementary Table 1), as an important part of our analyses has been made possible by the sharing of their work. We also thank Unidad de Bioinformática y Estadística, Centro de Investigación Príncipe Felipe, for allowing us to use the Computer Cluster to perform some of the bioinformatic analysis.

Published
2021

38. HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women

Author

Alonso, Selena, primary, Vidal, Marta, additional, Ruiz-Olalla, Gemma, additional, González, Raquel, additional, Jairoce, Chenjerai, additional, Manaca, M. Nelia, additional, Vázquez-Santiago, Miquel, additional, Balcells, Reyes, additional, Vala, Anifa, additional, Rupérez, María, additional, Cisteró, Pau, additional, Fuente-Soro, Laura, additional, Angov, Evelina, additional, Coppel, Ross L., additional, Gamain, Benoit, additional, Cavanagh, David, additional, Beeson, James G., additional, Nhacolo, Arsenio, additional, Sevene, Esperança, additional, Aponte, John J., additional, Macete, Eusébio, additional, Aguilar, Ruth, additional, Mayor, Alfredo, additional, Menéndez, Clara, additional, Dobaño, Carlota, additional, and Moncunill, Gemma, additional

Published
2021
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39. Reduced Placental Transfer of Antibodies Against a Wide Range of Microbial and Vaccine Antigens in HIV-Infected Women in Mozambique

Author

Alonso, Selena, primary, Vidal, Marta, additional, Ruiz-Olalla, Gemma, additional, González, Raquel, additional, Manaca, M. Nelia, additional, Jairoce, Chenjerai, additional, Vázquez-Santiago, Miquel, additional, Balcells, Reyes, additional, Vala, Anifa, additional, Rupérez, María, additional, Cisteró, Pau, additional, Fuente-Soro, Laura, additional, Cova, Marta, additional, Angov, Evelina, additional, Nhacolo, Arsenio, additional, Sevene, Esperança, additional, Aponte, John J., additional, Macete, Eusebio, additional, Aguilar, Ruth, additional, Mayor, Alfredo, additional, Menéndez, Clara, additional, Dobaño, Carlota, additional, and Moncunill, Gemma, additional

Published
2021
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40. Plasma MicroRNA Profiling of Plasmodium falciparum Biomass and Association with Severity of Malaria Disease

Author

Gupta, Himanshu, primary, Rubio, Mercedes, additional, Sitoe, Antonio, additional, Varo, Rosauro, additional, Cisteró, Pau, additional, Madrid, Lola, additional, Cuamba, Inocencia, additional, Jimenez, Alfons, additional, Martiáñez-Vendrell, Xavier, additional, Barrios, Diana, additional, Pantano, Lorena, additional, Brimacombe, Allison, additional, Bustamante, Mariona, additional, Bassat, Quique, additional, and Mayor, Alfredo, additional

Published
2021
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41. Additional file 1 of Field performance of ultrasensitive and conventional malaria rapid diagnostic tests in southern Mozambique

Author

Galatas, Beatriz, Mayor, Alfredo, Himanshu Gupta, Balanza, Núria, Ihn Kyung Jang, Nhamussua, Lidia, Simone, Wilson, Cisteró, Pau, Chidimatembue, Arlindo, Munguambe, Humberto, Saúte, Francisco, Aide, Pedro, and Bassat, Quique

Abstract

Additional file 1: Table S1. Definitions of performance indicators used. TP = True positive, FP = False positive, TN = True negative, FN = False negative. Table S2. Study population characteristics, overall and by region

Published
2020
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42. Validity of a minimally invasive autopsy tool for cause of death determination in pediatric deaths in Mozambique: An observational study

Author

Bassat, Quique, Castillo, Paola, Martínez, Miguel J., Jordao, Dercio, Lovane, Lucilia, Hurtado, Juan Carlos, Nhampossa, Tacilta, Santos Ritchie, Paula, Bandeira, Sónia, Sambo, Calvino, Chicamba, Valeria, Ismail, Mamudo R., Carrilho, Carla, Lorenzoni, Cesaltina, Fernandes, Fabiola, Cisteró, Pau, Mayor, Alfredo, Cossa, Anelsio, Mandomando, Inacio, Navarro, Mireia, Casas, Isaac, Vila, Jordi, Munguambe, Khátia, Maixenchs, Maria, Sanz, Ariadna, Quintó, Llorenç, Macete, Eusebio, Alonso, Pedro, Menéndez, Clara, and Ordi, Jaume

Subjects
Autopsy -- Evaluation, Child death -- Diagnosis, Biological sciences
Abstract

Background In recent decades, the world has witnessed unprecedented progress in child survival. However, our knowledge of what is killing nearly 6 million children annually in low- and middle-income countries remains poor, partly because of the inadequacy and reduced precision of the methods currently utilized in these settings to investigate causes of death (CoDs). The study objective was to validate the use of a minimally invasive autopsy (MIA) approach as an adequate and more acceptable substitute for the complete diagnostic autopsy (CDA) for pediatric CoD investigation in a poor setting. Methods and findings In this observational study, the validity of the MIA approach in determining the CoD was assessed in 54 post-neonatal pediatric deaths (age range: [greater than or equal to]1 mo to 15 y) in a referral hospital of Mozambique by comparing the results of the MIA with those of the CDA. Concordance in the category of disease obtained by the two methods was evaluated by the Kappa statistic, and the sensitivity, specificity, and positive and negative predictive values of the MIA diagnoses were calculated. A CoD was identified in all cases in the CDA and in 52/54 (96%) of the cases in the MIA, with infections and malignant tumors accounting for the majority of diagnoses. The MIA categorization of disease showed a substantial concordance with the CDA categorization (Kappa = 0.70, 95% CI 0.49-0.92), and sensitivity, specificity, and overall accuracy were high. The ICD-10 diagnoses were coincident in up to 75% (36/48) of the cases. The MIA allowed the identification of the specific pathogen deemed responsible for the death in two-thirds (21/32; 66%) of all deaths of infectious origin. Discrepancies between the MIA and the CDA in individual diagnoses could be minimized with the addition of some basic clinical information such as those ascertainable through a verbal autopsy or clinical record. The main limitation of the analysis is that both the MIA and the CDA include some degree of expert subjective interpretation. Conclusions The MIA showed substantial concordance with CDA for CoD identification in this series of pediatric deaths in Mozambique. This minimally invasive approach, simpler and more readily acceptable than the more invasive CDA, could provide robust data for CoD surveillance, especially in resource-limited settings, which could be helpful for guiding child survival strategies in the future., Author(s): Quique Bassat 1,2,3,*, Paola Castillo 1,4, Miguel J. Martínez 1,5, Dercio Jordao 6, Lucilia Lovane 6, Juan Carlos Hurtado 1,5, Tacilta Nhampossa 2,7, Paula Santos Ritchie 7, Sónia Bandeira [...]

Published
2017
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43. No Evidence of False-negative P. Falciparum Rapid Diagnostic Results in Monrovia, Liberia

Author

King, Mandella, primary, George, Alexander E., additional, Cisteró, Pau, additional, Tarr-Attia, Christine K., additional, Arregui, Beatriz, additional, Omeonga, Senga, additional, Chen, Haily, additional, García-Sípido, Ana Meyer, additional, Sarukhan, Adelaida, additional, Bassat, Quique, additional, Lansana, Dawoh Peter, additional, and Mayor, Alfredo, additional

Published
2021
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44. SARS-CoV-2 Seroprevalence and Antibody Kinetics Among Health Care Workers in a Spanish Hospital After 3 Months of Follow-up

Author

Moncunill, Gemma, primary, Mayor, Alfredo, additional, Santano, Rebeca, additional, Jiménez, Alfons, additional, Vidal, Marta, additional, Tortajada, Marta, additional, Sanz, Sergi, additional, Méndez, Susana, additional, Llupià, Anna, additional, Aguilar, Ruth, additional, Alonso, Selena, additional, Barrios, Diana, additional, Carolis, Carlo, additional, Cisteró, Pau, additional, Chóliz, Eugenia, additional, Cruz, Angeline, additional, Fochs, Silvia, additional, Jairoce, Chenjerai, additional, Hecht, Jochen, additional, Lamoglia, Montserrat, additional, Martínez, Mikel J, additional, Moreno, Javier, additional, Mitchell, Robert A, additional, Ortega, Natalia, additional, Pey, Nuria, additional, Puyol, Laura, additional, Ribes, Marta, additional, Rosell, Neus, additional, Figueroa-Romero, Antía, additional, Sotomayor, Patricia, additional, Torres, Sara, additional, Williams, Sarah, additional, Barroso, Sonia, additional, Vilella, Anna, additional, Trilla, Antoni, additional, Varela, Pilar, additional, Dobaño, Carlota, additional, and Garcia-Basteiro, Alberto L, additional

Published
2020
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45. Shifts in P. falciparum genetic structure and gametocyte markers in the transition to elimination

Author

Gupta, Himanshu, primary, Galatas, Beatriz, additional, Chidimatembue, Arlindo, additional, Simone, Wilson, additional, Matambisso, Gloria, additional, Pujol, Arnau, additional, Ruiz-Arenas, Carlos, additional, Gonzalez, Juan, additional, Nhamussa, Lidia, additional, Cisteró, Pau, additional, Rabinovich, Regina, additional, Alonso, Pedro, additional, Saúte, Francisco, additional, Aide, Pedro, additional, and Mayor, Alfredo, additional

Published
2020
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46. Effect of mass dihydroartemisinin–piperaquine administration in southern Mozambique on the carriage of molecular markers of antimalarial resistance

Author

Gupta, Himanshu, primary, Galatas, Beatriz, additional, Chidimatembue, Arlindo, additional, Huijben, Silvie, additional, Cisteró, Pau, additional, Matambisso, Gloria, additional, Nhamussua, Lidia, additional, Simone, Wilson, additional, Bassat, Quique, additional, Ménard, Didier, additional, Ringwald, Pascal, additional, Rabinovich, N. Regina, additional, Alonso, Pedro L., additional, Saúte, Francisco, additional, Aide, Pedro, additional, and Mayor, Alfredo, additional

Published
2020
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47. SARS-CoV-2 infections and antibody responses among health care workers in a Spanish hospital after a month of follow-up

Author

Moncunill, Gemma, primary, Mayor, Alfredo, additional, Santano, Rebeca, additional, Jiménez, Alfons, additional, Vidal, Marta, additional, Tortajada, Marta, additional, Sanz, Sergi, additional, Méndez, Susana, additional, Llupià, Anna, additional, Aguilar, Ruth, additional, Alonso, Selena, additional, Barrios, Diana, additional, Carolis, Carlo, additional, Cisteró, Pau, additional, Chóliz, Eugenia, additional, Cruz, Angeline, additional, Fochs, Silvia, additional, Jairoce, Chenjerai, additional, Hecht, Jochen, additional, Lamoglia, Montserrat, additional, Martínez, Mikel J., additional, Moreno, Javier, additional, Mitchell, Robert A., additional, Ortega, Natalia, additional, Pey, Nuria, additional, Puyol, Laura, additional, Ribes, Marta, additional, Rosell, Neus, additional, Sotomayor, Patricia, additional, Torres, Sara, additional, Williams, Sarah, additional, Barroso, Sonia, additional, Vilella, Anna, additional, Trilla, Antoni, additional, Varela, Pilar, additional, Dobaño, Carlota, additional, and Garcia-Basteiro, Alberto L, additional

Published
2020
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48. Reduced placental transfer of antibodies against microbial and vaccine antigens in HIV-infected women in Mozambique

Author

Alonso, Selena, primary, Vidal, Marta, additional, Ruiz-Olalla, Gemma, additional, González, Raquel, additional, Manaca, M. Nelia, additional, Jairoce, Chenjerai, additional, Vázquez-Santiago, Miquel, additional, Balcells, Reyes, additional, Vala, Anifa, additional, Ruperez, María, additional, Cisteró, Pau, additional, Fuente-Soro, Laura, additional, Cova, Marta, additional, Angov, Evelina, additional, Nhacolo, Arsenio, additional, Sevene, Esperança, additional, Aponte, John J., additional, Macete, Eusébio, additional, Aguilar, Ruth, additional, Mayor, Alfredo, additional, Menéndez, Clara, additional, Dobaño, Carlota, additional, and Moncunill, Gemma, additional

Published
2020
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49. Plasma microRNA profiling for malaria disease: association with severity and P. falciparum biomass

Author

Gupta, Himanshu, primary, Rubio, Mercedes, additional, Sitoe, Antonio, additional, Varo, Rosauro, additional, Cisteró, Pau, additional, Madrid, Lola, additional, Cuamba, Inocencia, additional, Jimenez, Alfons, additional, Martiáñez-Vendrell, Xavier, additional, Barrios, Diana, additional, Pantano, Lorena, additional, Brimacombe, Allison, additional, Bustamante, Mariona, additional, Bassat, Quique, additional, and Mayor, Alfredo, additional

Published
2020
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50. Association of Maternal Factors and HIV Infection With Innate Cytokine Responses of Delivering Mothers and Newborns in Mozambique

Author

Moncunill, Gemma, primary, Dobaño, Carlota, additional, González, Raquel, additional, Smolen, Kinga K., additional, Manaca, Maria N., additional, Balcells, Reyes, additional, Jairoce, Chenjerai, additional, Cisteró, Pau, additional, Vala, Anifa, additional, Sevene, Esperança, additional, Rupérez, María, additional, Aponte, John J., additional, Macete, Eusébio, additional, Menéndez, Clara, additional, Kollmann, Tobias R., additional, and Mayor, Alfredo, additional

Published
2020
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