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3. Antilipidemic and Hepatoprotective Effects of Ethanol Extract of Justicia spicigera in Streptozotocin Diabetic Rats

Author

Murillo-Villicaña, Marina, primary, Noriega-Cisneros, Ruth, additional, Peña-Montes, Donovan J., additional, Huerta-Cervantes, Maribel, additional, Aguilera-Méndez, Asdrubal, additional, Cortés-Rojo, Christian, additional, Salgado-Garciglia, Rafael, additional, Montoya-Pérez, Rocío, additional, Riveros-Rosas, Héctor, additional, and Saavedra-Molina, Alfredo, additional

Published
2022
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9. PROGRAM MANAGER PREPARATION AND ACQUISITION OUTCOMES

Author

Dunlap, Jeffrey R., Cisneros, Ruth, Marine Corps Systems Command, Graduate School of Defense Management (GSDM), Updike, Andrew R., Dunlap, Jeffrey R., Cisneros, Ruth, Marine Corps Systems Command, Graduate School of Defense Management (GSDM), and Updike, Andrew R.

Abstract

The purpose of this project was to compare the program manager preparation of uniformed officers in United States Air Force, Army, Navy, and Marine Corps, and then analyze acquisition outcomes. Entry-level requirements to become a program manager in the four branches were identified and similarities and differences were established. Cost and schedule performance datasets from 2017-2019 were analyzed using select acquisition reports managed by uniformed personnel. The Air Force ranked best in cost and schedule performance. Reviewing the preparational process of each branch and comparing cost and schedule performance over a three-year period identified a correlation between early exposure to acquisition and better outcomes in cost and schedule., Captain, United States Marine Corps, Approved for public release. Distribution is unlimited.

Published
2021

10. Effect of the Ethyl Acetate Extract of Justicia spicigera and Biotin in Liver of Diabetic Rats

Author

Murillo‐Villicaña, Marina, primary, Noriega‐Cisneros, Ruth, additional, Peña‐Montes, Donovan, additional, Huerta‐Cervantes, Maribel, additional, Aguilera‐Méndez, Asdrúbal, additional, Manzo‐Avalos, Salvador, additional, Salgado‐Garciglia, Rafael, additional, Montoya‐Pérez, Rocío, additional, Cortés‐Rojo, Christian, additional, and Saavedra‐Molina, Alfredo, additional

Published
2021
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14. Eryngium carlinae Ethanol Extract Corrects Lipid Abnormalities in Wistar Rats with Experimental Diabetes.

Author

Noriega-Cisneros, Ruth, Peña-Montes, Donovan J., Huerta-Cervantes, Maribel, Torres-Martínez, Rafael, Huerta, Miguel, Manzo-Avalos, Salvador, Salgado-Garciglia, Rafael, and Saavedra-Molina, Alfredo

Subjects
*ANIMAL experimentation, *CHOLESTEROL, *DIABETES, *HIGH density lipoproteins, *LIPIDS, *LOW density lipoproteins, *MEDICINAL plants, *ORAL drug administration, *OXIDOREDUCTASES, *RATS, *PLANT extracts, *ATORVASTATIN, THERAPEUTIC use of plant extracts
Abstract

Abnormalities in lipid metabolism, associated with increased risk of cardiovascular disease (CVD), frequently occur in people with diabetes. Eryngium carlinae is a plant used in traditional medicine to treat lipid abnormalities. The chemical composition and hypolipidemic activity of the ethanolic extract of E. carlinae were analyzed to broaden our knowledge of its mechanism of action. The ethanolic extract of E. carlinae was tested for hypolipidemic activity by oral administration for 40 days. Atorvastatin, a widely used statin, was also administered to compare its effect with that of the extract. Serum was used for analysis of the lipid profile and liver microsomes to assess 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and low-density lipoprotein receptor (LDL-r) levels. The extract was able to reduce total cholesterol and non-high-density lipoprotein cholesterol (C-HDL) levels and increase the C-HDL levels reduced in diabetes, decreasing the atherogenic index and therefore the risk of suffering CVD at the same level as atorvastatin. The HMG-CoA reductase activity and LDL-r levels were not modified by the administration of E. carlinae. The results demonstrate the hypolipidemic potential of ethanol extract of E. carlinae and support its use in traditional medicine as a hypolipidemic agent. [ABSTRACT FROM AUTHOR]

Published
2020
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15. Antioxidant Effects of Eryngium carlinae in Diabetic Rats

Author

García-Cerrillo, Diana, primary, Noriega-Cisneros, Ruth, additional, Peña-Montes, Donovan, additional, Huerta-Cervantes, Maribel, additional, Silva-Ríos, Mónica, additional, Salgado-Garciglia, Rafael, additional, Montoya-Pérez, Rocío, additional, and Saavedra-Molina, Alfredo, additional

Published
2018
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17. Antioxidant effect of Justicia spicigera in liver from diabetic rats

Author

Murillo‐Villicaña, Marina, primary, Martínez‐Mora, José A., additional, Noriega‐Cisneros, Ruth, additional, Manzo‐Avalos, Salvador, additional, Salgado‐Garciglia, Rafael, additional, Cortés‐Rojo, Christian, additional, Montoya‐Pérez, Rocío, additional, and Saavedra‐Molina, Alfredo, additional

Published
2018
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19. Improvement of diabetic cardiomyopathy by Eryngium carlinae

Author

García‐Cerrillo, Diana, primary, Noriega‐Cisneros, Ruth, additional, Salgado‐Garciglia, Rafael, additional, Manzo‐Avalos, Salvador, additional, Clemente‐Guerrero, Mónica, additional, Montoya‐Pérez, Rocío, additional, and Saavedra‐Molina, Alfredo, additional

Published
2017
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21. Estrés oxidativo y nitrosativo en mitocondrias de cerebro de rata durante la diabetes

Author

Noriega Cisneros, Ruth and Alfredo Saavedra Molina

Subjects
Cerebro, Nitrosativo, 6 [cti], Diabetes, Estrés oxidativo, IIQB-M-2008-0004, Oxidativo, Rata, Mitocondrias, Estrés
Abstract

Instituto de Investigaciones Químico Biológicas. Maestría en Ciencias en Biología Experimental Among the multiple complications of diabetes mellitus (DM), there is diabetic encephalopathy, characterized by deterioration of cognitive functions, electrophysiological changes, structural and neurochemical abnormalities in the brain. The relationship between neuronal damage and hyperglycemia is not well elucidated. Because DM damage begins long before symptoms appear, it is interesting to evaluate the development of this disease so that it can be controlled before the damage is irreversible. Chronic hyperglycemia increases the oxidation of glucose and, as a consequence, the reducing equivalents increase, which are oxidized in the respiratory chain generating an increase in the superoxide anion and as a consequence an increase in mitochondrial oxidative stress. With the objective of evaluating oxidative and nitrosative stress during DM, in the present study nitric oxide (–NO), thiobarbituric acid (TBARS), total glutathione (GSHT), peroxitrite (ONOO-) reactive substances were determined. Aconite activity was measured in brain mitochondria of diabetic rats as markers of oxidative and nitrosative stress. At the first five weeks of diabetes, the results showed an increase in the synthesis of –NO (12.15 ± 0.78 nmol / mg protein / hour vs. control, 9.48 ± 0.09 nmol / mg protein hour, p

Published
2008

22. Fermentative capacity of Kluyveromyces marxianus and Saccharomyces cerevisiae after oxidative stress.

Author

Arellano‐Plaza, Melchor, Noriega‐Cisneros, Ruth, Clemente‐Guerrero, Mónica, González‐Hernández, Juan Carlos, Robles‐Herrera, Patsy Dayana, Manzo‐Ávalos, Salvador, Saavedra‐Molina, Alfredo, and Gschaedler‐Mathis, Anne

Subjects
*SACCHAROMYCES cerevisiae, *KLUYVEROMYCES marxianus, *OXIDATIVE stress, *OXIDATION-reduction reaction, *FERMENTATION
Abstract

Volatile compound production during alcoholic fermentation has been studied in the production of many beverages. Temperature, yeast strain, nutrients and pH have been identified as important factors in the production of volatile compounds. In addition, other factors could influence this production during the fermentation process as well. Oxidative stress could occur during yeast biomass production because oxygen is an essential nutrient that is added to the growth medium. The fermentation parameters and the volatile compound production of one Saccharomyces cerevisiae strain (MC4) and two Kluyveromyces marxianus strains (OFF1 and SLP1) were evaluated in relation to fermentation parameters after oxidative stress induced by hydrogen peroxide or menadione. These yeasts were compared with S. cerevisiae W303-1A and showed significant differences in ethanol production, ethanol yield and maximum ethanol production rate. K. marxianus (OFF1) showed better fermentative capacity after oxidative stress. The higher alcohol production decreased after oxidative stress by >35% after 72 h fermentation time, and the amyl alcohol decreased at a higher level (>60%); however, the isobutanol production increased after oxidative stress between 1.5 and 4 times. The yeasts produced significant concentrations of esters however ethyl lactate, ethyl caprylate and the ethyl caproate were not detected in the control fermentation, while in the stress fermentation they accounted for up to 3 mg/L. These results demonstrate that oxidative stress can play an important role in the final aroma profile; but it is necessary to guarantee adequate yeast growth to obtain the volatile compounds desired. Copyright © 2017 The Institute of Brewing & Distilling [ABSTRACT FROM AUTHOR]

Published
2017
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23. Uso del suelo y calidad del agua en quebradas de fincas con sistemas silvopastoriles en la subcuenca del Río Jabonal, Costa Rica

Author

Auquilla Cisneros, Ruth C., Salazar, S., and CATIE - Centro Agronómico Tropical de Investigación y Enseñanza

Subjects
PROPIEDADES FISICOQUÍMICAS, FACTORES CLIMÁTICOS, EXPLOTACIONES AGRARIAS, GANADERÍA, UTILIZACIÓN DE LA TIERRA, COSTA RICA, CALIDAD DEL AGUA, POLUCIÓN DEL AGUA, Sede Central, ANÁLISIS BIOLÓGICO, SISTEMAS SILVOPASCÍCOLAS
Abstract

Tesis (Mag.Sc.) - CATIE, Turrialba (Costa Rica), 2005 La investigación se realizó de Marzo a Septiembre del 2005 en los poblados de Peñas Blancas y Cerrillos en la subcuenca del Río Jabonal, en Esparza, Costa Rica. El principal objetivo de este estudio fue analizar la variación de la calidad del agua y su relación con los usos de suelo y la época climática en fincas ganaderas, mediante parámetros físico químicos y de macroinvertebrados bentónicos. Con este objetivo se monitorearon ocho quebradas y el río Jabonal. La población en la zona de estudio mostró un gran interés por participar en acciones para disminuir los efectos negativos de la actividad ganadera en la calidad del agua y están prestos a recibir apoyo y capacitación sobre este tema. This research was carried out from March to September of 2005 in the towns of Peñas Blancas and Cerrillos in the sub-basin of Río Jabonal, Esparza, Costa Rica. The principal objective of this study was to analyze the variation of water quality and its relationship with land uses and seasons on farMON with silvopastoral systeMON using chimical-physical and benthonic macro-invertebrate parameters. Eight streaMON and the Jabonal River were monitored. The population in the study area showed great interest in participating in activities to decrease the negative effects of cattle ranching on water quality and they are open to receiving help and training on the topic.

Published
2005

25. Potencial antioxidante de 10 accesiones de yacón, Smallanthus sonchifolius (Poepp. & Endl.) H. Robinson, procedentes de Cajamarca - Perú

Author

Arnao Salas, Acela Inés, Seminario, Juan, Cisneros, Ruth, Trabucco, Juan, Arnao Salas, Acela Inés, Seminario, Juan, Cisneros, Ruth, and Trabucco, Juan

Abstract

Yacon (Smallanthus sonchifolius) is part of our food and medicinal biodiversity and both roots and leaves are used due to their antioxidant, hypoglycemic and antibacterial properties. Consequently its use as functional food and/or nutraceutical is promising. Objectives: To determine the antioxidant capacity of 10 yacon accessions native from Cajamarca. Design: Descriptive, cross sectional and prospective study. Setting: Biochemistry and Nutrition Research Center, Faculty of Medicine, Universidad Nacional Mayor de San Marcos (UNMSM), and Universidad Nacional de Cajamarca (UNC), Peru. Biological material: Yacon leaves and roots. Interventions: Yacon leaves and roots of plants cultivated in the Experimental Field of the Roots and Andean Tubers Program, Cajamarca's city (2 536 meters above sea level), were used, from the collection that supports the UNC Faculty of Agrarian Sciences. Origin of these accessions were Yanamango, Chuquibamba, Yanac, Cumbico, Bambamarca, Sapuc, Can Can, Jose Galvez, Contumaza, and San Ignacio. DPPH's (1,1-difenil-2-picrilhidrazil) test was used and phenol and flavonoid total content was measured. Ascorbic acid, gallic acid (AG) and quercetin (Q) were used as reference. Main outcome measures: Total phenol and flavonoid content. Results: Root extracts radical DPPH capture presented an IC50, range 1,92-6,32 uL of root/mL, and its total phenols varied from 217,5-352,4 ug EAG/mL of root. Leaves hydroalcoholic extracts showed an IC50 for radical DPPH capture between 44,2-110,3 ug of dry leaf/mL. Its total phenols ranged between 7,7-22,7 mg EAG/g of leaf and flavonoids between 2,2-4,4 mg EQ/g of leaf. Conclusions: In the present study, accessions with major antioxidant potential for leaves and roots came from Yanamango and Chuquibamba. These results might relate to different geographical distribution, El yacón (Smallanthus sonchifolius) es parte de nuestra biodiversidad alimentaria y medicinal, utilizándose tanto las raíces como las hojas, por sus propiedades antioxidantes, hipoglicemiantes y antibacterianas. Por estas características, su uso como alimento funcional y/o nutracéutico es promisorio. Objetivos: Evaluar la capacidad antioxidante de 10 accesiones de yacón procedentes de Cajamarca. Diseño: Estudio descriptivo, transversal y prospectivo. Instituciones: Centro de Investigación de Bioquímica y Nutrición, Facultad de Medicina, UNMSM y Universidad Nacional de Cajamarca (UNC), Perú. Material biológico: Hojas y raíces de yacón. Intervenciones: Se usó hojas y raíces de plantas de yacón cultivadas en el Campo Experimental del Programa de Raíces y Tubérculos Andinos, ciudad de Cajamarca (2 536 msnm), de la colección que mantiene la Facultad de Ciencias Agrarias de la UNC. La procedencia de estas accesiones fueron las localidades Yanamango, Chuquibamba, Yanac, Cumbico, Bambamarca, Sapuc, Can Can, José Gálvez, Contumazá y San Ignacio. Se empleó la prueba de DPPH (1,1-difenil-2-picrilhidracilo) y se midió el contenido de fenoles totales y flavonoides totales. Se usó ácido ascórbico, ácido gálico (AG) y quercetina (Q) como referencia, respectivamente. Principales medidas de resultados: Contenido de fenoles totales y flavonoides totales. Resultados: Para la captación del radical DPPH, los extractos de raíces presentaron un IC50, en el rango de 1,92 a 6,32 uL de raíz/mL. Sus fenoles totales variaron de 217,5 a 352,4 ug EAG/mL de raíz. Los extractos hidroalcohólicos de hojas mostraron un IC50, para la captación del radical DPPH, entre 44,2 y 110,3 ug de hoja seca/mL. Sus fenoles totales estuvieron en el rango de 7,7 a 22,7 mg EAG/g de hoja y el de flavonoides entre 2,2 y 4,4 mg EQ/g de hoja. Conclusiones: En el presente estudio, las accesiones con mayor potencial antioxidante, para hojas y raíces, provinieron de las localidades de Yanamango y Chuquibamba. Estos resulta

Published
2011

39. Fermentative capacity of Kluyveromyces marxianusand Saccharomyces cerevisiaeafter oxidative stress

Author

Arellano‐Plaza, Melchor, Noriega‐Cisneros, Ruth, Clemente‐Guerrero, Mónica, González‐Hernández, Juan Carlos, Robles‐Herrera, Patsy Dayana, Manzo‐Ávalos, Salvador, Saavedra‐Molina, Alfredo, and Gschaedler‐Mathis, Anne

Abstract

Volatile compound production during alcoholic fermentation has been studied in the production of many beverages. Temperature, yeast strain, nutrients and pH have been identified as important factors in the production of volatile compounds. In addition, other factors could influence this production during the fermentation process as well. Oxidative stress could occur during yeast biomass production because oxygen is an essential nutrient that is added to the growth medium. The fermentation parameters and the volatile compound production of one Saccharomyces cerevisiaestrain (MC4) and two Kluyveromyces marxianusstrains (OFF1 and SLP1) were evaluated in relation to fermentation parameters after oxidative stress induced by hydrogen peroxide or menadione. These yeasts were compared with S. cerevisiaeW303–1A and showed significant differences in ethanol production, ethanol yield and maximum ethanol production rate. K. marxianus(OFF1) showed better fermentative capacity after oxidative stress. The higher alcohol production decreased after oxidative stress by >35% after 72 h fermentation time, and the amyl alcohol decreased at a higher level (>60%); however, the isobutanol production increased after oxidative stress between 1.5 and 4 times. The yeasts produced significant concentrations of esters however ethyl lactate, ethyl caprylate and the ethyl caproate were not detected in the control fermentation, while in the stress fermentation they accounted for up to 3 mg/L. These results demonstrate that oxidative stress can play an important role in the final aroma profile; but it is necessary to guarantee adequate yeast growth to obtain the volatile compounds desired. Copyright © 2017 The Institute of Brewing & Distilling

Published
2017
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45. Deleterious effects of oxidative and nitrosative stress on aconitase activity in brain mitochondria during diabetes

Author

Noriega‐Cisneros, Ruth, primary, Esquivel‐Gutiérrez, Edgar, additional, Clemente‐Guerrero, Mónica, additional, Caudillo‐Noriega, Evangelina, additional, Gutiérrez‐Pérez, Areli, additional, Calderón‐Cortés, Elizabeth, additional, Cortés‐Rojo, Christian, additional, Manzo‐Ávalos, Salvador, additional, and Saavedra‐Molina, Alfredo, additional

Published
2007
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46. ROLE OF MITOCHONDRIAL NITRIC OXIDE AND REACTIVE OXYGEN SPECIES IN RAT KIDNEY DURING DIABETES

Author

Esquivel‐Gutiérrez, Edgar, primary, Noriega‐Cisneros, Ruth, additional, Clemente‐Guerrero, Mónica, additional, Caudillo‐Noriega, Evangelina, additional, Gutiérrez‐Pérez, Areli, additional, Calderón‐Cortés, Elizabeth, additional, Cortés‐Rojo, Christian, additional, Manzo‐Ávalos, Salvador, additional, and Saavedra‐Molina, Alfredo, additional

Published
2007
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47. DIFFERENT SUSCEPTIBILITY OF MITOCHONDRIAL RESPIRATORY CHAIN FOR NITRIC OXIDE IN DIFFERENT ORGANS DURING HYPERTENSION

Author

Calderón‐Cortés, Elizabeth, primary, Cortés‐Rojo, Christian, additional, Clemente‐Guerrero, Mónica, additional, Gutiérrez‐Pérez, Areli, additional, Esquivel‐Gutiérrez, Edgar, additional, Caudillo‐Noriega, Evangelina, additional, Noriega‐Cisneros, Ruth, additional, Manzo‐Ávalos, Salvador, additional, and Saavedra‐Molina, Alfredo, additional

Published
2007
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48. ROLE OF LIPOPEROXIDATION ON OXIDATIVE DAMAGE TO MITOCHONDRIAL RESPIRATORY CHAIN

Author

Cortés‐Rojo, Christian, primary, Estrada‐Villagómez, Mirella, additional, Corona‐Gómez, Rosalía, additional, Calderón‐Cortés, Elizabeth, additional, Clemente‐Guerrero, Mónica, additional, Esquivel‐Gutiérrez, Edgar, additional, Caudillo‐Noriega, Evangelina, additional, Noriega‐Cisneros, Ruth, additional, Manzo‐Ávalos, Salvador, additional, and Saavedra‐Molina, Alfredo, additional

Published
2007
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49. Hypolipidemic Activity of Eryngium carlinae on Streptozotocin-Induced Diabetic Rats.

Author

Boldogh, Istvan, Clemente-Guerrero, Mónica, Cortés-Rojo, Christian, Esquivel-Gutiérrez, Edgar, Manzo-Avalos, Salvador, Noriega-Cisneros, Ruth, Ortiz-Ávila, Omar, Saavedra-Molina, Alfredo, and Salgado-Garciglia, Rafael

Abstract

Diabetes mellitus (DM) is a significant risk factor for the development of cardiovascular complications. This study was undertaken to investigate the effect of chronic administration of ethanolic extract of Eryngium carlinae on glucose, creatinine, uric acid, total cholesterol, and triglycerides levels in serum of streptozotocin- (STZ-) induced diabetic rats. Triglycerides, total cholesterol, and uric acid levels increased in serum from diabetic rats. The treatment with E. carlinae prevented these changes. The administration of E. carlinae extract reduced the levels of creatinine, uric acid, total cholesterol, and triglycerides. Thus administration of E. carlinae is able to reduce hyperlipidemia related to the cardiovascular risk in diabetes mellitus. [ABSTRACT FROM AUTHOR]

Published
2012
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50. Protective Effect of the Hexanic Extract of Eryngium carlinae Inflorescences In Vitro, in Yeast, and in Streptozotocin-Induced Diabetic Male Rats.

Author

Peña-Montes, Donovan J., Huerta-Cervantes, Maribel, Ríos-Silva, Mónica, Trujillo, Xóchitl, Huerta, Miguel, Noriega-Cisneros, Ruth, Salgado-Garciglia, Rafael, and Saavedra-Molina, Alfredo

Subjects
TERPENES, INFLORESCENCES, BLOOD sugar, OXIDANT status, VITAMIN C, EXTRACTS
Abstract

In the present study, we investigated the composition and antioxidant activity of the hexanic extract of Eryngium carlinae inflorescences by employing in vitro assays to measure antioxidant capacity and 2,2-diphenyl-1-picrylhydrazyl scavenging activity. We also applied the hexanic extract to Saccharomyces cerevisiae, under hydrogen peroxide-induced stress. Finally, we tested the extract in male Wistar rats with and without streptozotocin-induced diabetes. The compounds in the hexanic extract were analyzed by gas-chromatography-mass spectrometry, which revealed mainly terpenes and sesquiterpenes, including (Z)β-farnesene (38.79%), β-pinene (17.53%), calamene (13.3%), and α-farnesene (10.38%). In vitro and in S. cerevisiae, the extract possessed antioxidant activity at different concentrations, compared to ascorbic acid (positive control). In normoglycemic and hyperglycemic rats, oral administration of 30 mg/kg of the extract reduced blood glucose levels; lipid peroxidation in liver, kidney and brain; protein carbonylation; and reactive oxygen species (ROS) production. It also increased catalase activity in the brain, kidneys and liver. These findings show that this hexanic extract of E. carlinae inflorescences possessed antioxidant properties. [ABSTRACT FROM AUTHOR]

Published
2019
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