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2. Dynamic spinal orthoses self-reported effects in patients with back pain due to vertebral fragility fractures: A multi-center prospective cohort study.

Author

de Sire, Alessandro, Lippi, Lorenzo, Calafiore, Dario, Marotta, Nicola, Mezian, Kamal, Chiaramonte, Rita, Cisari, Carlo, Vecchio, Michele, Ammendolia, Antonio, and Invernizzi, Marco

Subjects
THERAPEUTIC use of vitamin D, THERAPEUTIC use of monoclonal antibodies, PAIN measurement, PEARSON correlation (Statistics), NONSTEROIDAL anti-inflammatory agents, ADRENOCORTICAL hormones, PATIENT compliance, CONSERVATIVE treatment, DIPHOSPHONATES, QUESTIONNAIRES, VISUAL analog scale, KYPHOSIS, SCOLIOSIS, FISHER exact test, ORTHOPEDIC apparatus, VERTEBRAL fractures, MANN Whitney U Test, DESCRIPTIVE statistics, FUNCTIONAL foods, BONE fractures, REHABILITATION centers, LONGITUDINAL method, ANALGESICS, CALCIUM, PARATHYROID hormone, RESEARCH, QUALITY of life, HEALTH outcome assessment, OSTEOPOROSIS, DATA analysis software, CONFIDENCE intervals, BODY movement, BACKACHE, LUMBAR pain, DIETARY supplements, EVALUATION
Abstract

BACKGROUND: Vertebral fragility fractures (VFFs) commonly result from low bone mass and microarchitecture deterioration of bone tissue. spinal orthoses are common non-pharmacological options for managing vertebral fracture pain. However, the effects of spinal orthoses on pain, physical functioning, and quality of life (QoL) are still debated. OBJECTIVE: This survey aimed to investigate the patients-reported outcomes of a dynamic spinal orthosis prescribed in the routine clinical practice of VFFs management. METHODS: This multi-center national-wide prospective cohort study assessed older patients (aged > 60 years) diagnosed with acute VFFs and prescribed with a dynamic spinal orthosis (Spinfast®). A survey questionnaire was realized and included sections on patient characterization, osteoporosis characterization, spinal orthosis, clinical outcomes, pain medications, and osteoporosis medications. The questionnaire was administered at baseline and after three months. A total of 68 patients completed the questionnaire at three months. Most patients had one or two VFFs and were treated with pain medications and osteoporosis medications. Compliance and tolerability of the spinal orthosis were assessed, and clinical outcomes such as pain intensity, physical functioning, and QoL were measured. RESULTS: The results showed no significant differences in outcomes between age subgroups. Italian physical medicine and rehabilitation physicians were commonly involved in the management of VFFs patients. Sixty-six patients completed the questionnaire. The results showed that pain intensity, physical functioning and QoL improved after three months of spinal orthosis wearing (p < 0.0001). CONCLUSION: The correct management of VFFs is mandatory to improve pain and reduce disability, and our findings suggested a positive role of dynamic spinal orthosis to improve the comprehensive management of VFFs patients. However, high-quality research trials are warranted to provide clear recommendations for the correct clinical management of VFF. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Sarcopenia and Aging

Author

Invernizzi, Marco, Baricich, Alessio, Cisari, Carlo, Maggi, Stefania, Series editor, Masiero, Stefano, editor, and Carraro, Ugo, editor

Published
2018
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5. Risk Factors and Outcome in Falls

Author

Baricich, Alessio, Invernizzi, Marco, Cisari, Carlo, Guglielmelli, Eugenio, Series editor, Sandrini, Giorgio, editor, Homberg, Volker, editor, Saltuari, Leopold, editor, Smania, Nicola, editor, and Pedrocchi, Alessandra, editor

Published
2018
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9. Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Author

Bellan, Mattia, Patti, Giuseppe, Hayden, Eyal, Azzolina, Danila, Pirisi, Mario, Acquaviva, Antonio, Aimaretti, Gianluca, Aluffi Valletti, Paolo, Angilletta, Roberto, Arioli, Roberto, Avanzi, Gian Carlo, Avino, Gianluca, Balbo, Piero Emilio, Baldon, Giulia, Baorda, Francesca, Barbero, Emanuela, Baricich, Alessio, Barini, Michela, Barone-Adesi, Francesco, Battistini, Sofia, Beltrame, Michela, Bertoli, Matteo, Bertolin, Stephanie, Bertolotti, Marinella, Betti, Marta, Bobbio, Flavio, Boffano, Paolo, Boglione, Lucio, Borrè, Silvio, Brucoli, Matteo, Calzaducca, Elisa, Cammarata, Edoardo, Cantaluppi, Vincenzo, Cantello, Roberto, Capponi, Andrea, Carriero, Alessandro, Casciaro, Francesco Giuseppe, Castello, Luigi Mario, Ceruti, Federico, Chichino, Guido, Chirico, Emilio, Cisari, Carlo, Cittone, Micol Giulia, Colombo, Crizia, Comi, Cristoforo, Croce, Eleonora, Daffara, Tommaso, Danna, Pietro, Della Corte, Francesco, De Vecchi, Simona, Dianzani, Umberto, Di Benedetto, Davide, Esposto, Elia, Faggiano, Fabrizio, Falaschi, Zeno, Ferrante, Daniela, Ferrero, Alice, Gagliardi, Ileana, Gaidano, Gianluca, Galbiati, Alessandra, Gallo, Silvia, Garavelli, Pietro Luigi, Gardino, Clara Ada, Garzaro, Massimiliano, Gastaldello, Maria Luisa, Gavelli, Francesco, Gennari, Alessandra, Giacomini, Greta Maria, Giacone, Irene, Giai Via, Valentina, Giolitti, Francesca, Gironi, Laura Cristina, Gramaglia, Carla, Grisafi, Leonardo, Inserra, Ilaria, Invernizzi, Marco, Krengli, Marco, Labella, Emanuela, Landi, Irene Cecilia, Landi, Raffaella, Leone, Ilaria, Lio, Veronica, Lorenzini, Luca, Maconi, Antonio, Malerba, Mario, Manfredi, Giulia Francesca, Martelli, Maria, Marzari, Letizia, Marzullo, Paolo, Mennuni, Marco, Montabone, Claudia, Morosini, Umberto, Mussa, Marco, Nerici, Ilaria, Nuzzo, Alessandro, Olivieri, Carlo, Padelli, Samuel Alberto, Panella, Massimiliano, Parisini, Andrea, Paschè, Alessio, Pau, Alberto, Pedrinelli, Anita Rebecca, Percivale, Ilaria, Re, Roberta, Rigamonti, Cristina, Rizzi, Eleonora, Rognoni, Andrea, Roveta, Annalisa, Salamina, Luigia, Santagostino, Matteo, Saraceno, Massimo, Savoia, Paola, Sciarra, Marco, Schimmenti, Andrea, Scotti, Lorenza, Spinoni, Enrico, Smirne, Carlo, Tarantino, Vanessa, Tillio, Paolo Amedeo, Vaschetto, Rosanna, Vassia, Veronica, Zagaria, Domenico, Zavattaro, Elisa, Zeppegno, Patrizia, Zottarelli, Francesca, and Sainaghi, Pier Paolo

Published
2020
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20. Abstract P4-10-15: Whole-body vibration combined with physical exercise to treat aromatase inhibitor-induced musculoskeletal symptoms in breast cancer women: Results of a pilot randomized controlled study

Author

Lippi, Lorenzo, primary, de Sire, Alessandro, additional, Ammendolia, Antonio, additional, Cisari, Carlo, additional, Venetis, Konstantinos, additional, Sajjadi, Elham, additional, Fusco, Nicola, additional, and Invernizzi, Marco, additional

Published
2022
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22. Information Survey on the Use of Complementary and Alternative Medicine

Author

Paoloni, Marco, primary, Agostini, Francesco, additional, Bernasconi, Sergio, additional, Bona, Gianni, additional, Cisari, Carlo, additional, Fioranelli, Massimo, additional, Invernizzi, Marco, additional, Madeo, Antonello, additional, Matucci-Cerinic, Marco, additional, Migliore, Alberto, additional, Quirino, Nicola, additional, Ventura, Carlo, additional, Viganò, Roberto, additional, and Bernetti, Andrea, additional

Published
2022
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27. Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19

Author

Bellan, Mattia, primary, Azzolina, Danila, additional, Hayden, Eyal, additional, Gaidano, Gianluca, additional, Pirisi, Mario, additional, Acquaviva, Antonio, additional, Aimaretti, Gianluca, additional, Aluffi Valletti, Paolo, additional, Angilletta, Roberto, additional, Arioli, Roberto, additional, Avanzi, Gian Carlo, additional, Avino, Gianluca, additional, Balbo, Piero Emilio, additional, Baldon, Giulia, additional, Baorda, Francesca, additional, Barbero, Emanuela, additional, Baricich, Alessio, additional, Barini, Michela, additional, Barone-Adesi, Francesco, additional, Battistini, Sofia, additional, Beltrame, Michela, additional, Bertoli, Matteo, additional, Bertolin, Stephanie, additional, Bertolotti, Marinella, additional, Betti, Marta, additional, Bobbio, Flavio, additional, Boffano, Paolo, additional, Boglione, Lucio, additional, Borrè, Silvio, additional, Brucoli, Matteo, additional, Calzaducca, Elisa, additional, Cammarata, Edoardo, additional, Cantaluppi, Vincenzo, additional, Cantello, Roberto, additional, Capponi, Andrea, additional, Carriero, Alessandro, additional, Casciaro, Giuseppe Francesco, additional, Castello, Luigi Mario, additional, Ceruti, Federico, additional, Chichino, Guido, additional, Chirico, Emilio, additional, Cisari, Carlo, additional, Cittone, Micol Giulia, additional, Colombo, Crizia, additional, Comi, Cristoforo, additional, Croce, Eleonora, additional, Daffara, Tommaso, additional, Danna, Pietro, additional, Della Corte, Francesco, additional, De Vecchi, Simona, additional, Dianzani, Umberto, additional, Di Benedetto, Davide, additional, Esposto, Elia, additional, Faggiano, Fabrizio, additional, Falaschi, Zeno, additional, Ferrante, Daniela, additional, Ferrero, Alice, additional, Gagliardi, Ileana, additional, Galbiati, Alessandra, additional, Gallo, Silvia, additional, Garavelli, Pietro Luigi, additional, Gardino, Clara Ada, additional, Garzaro, Massimiliano, additional, Gastaldello, Maria Luisa, additional, Gavelli, Francesco, additional, Gennari, Alessandra, additional, Giacomini, Greta Maria, additional, Giacone, Irene, additional, Giai Via, Valentina, additional, Giolitti, Francesca, additional, Gironi, Laura Cristina, additional, Gramaglia, Carla, additional, Grisafi, Leonardo, additional, Inserra, Ilaria, additional, Invernizzi, Marco, additional, Krengli, Marco, additional, Labella, Emanuela, additional, Landi, Irene Cecilia, additional, Landi, Raffaella, additional, Leone, Ilaria, additional, Lio, Veronica, additional, Lorenzini, Luca, additional, Maconi, Antonio, additional, Malerba, Mario, additional, Manfredi, Giulia Francesca, additional, Martelli, Maria, additional, Marzari, Letizia, additional, Marzullo, Paolo, additional, Mennuni, Marco, additional, Montabone, Claudia, additional, Morosini, Umberto, additional, Mussa, Marco, additional, Nerici, Ilaria, additional, Nuzzo, Alessandro, additional, Olivieri, Carlo, additional, Padelli, Samuel Alberto, additional, Panella, Massimiliano, additional, Parisini, Andrea, additional, Paschè, Alessio, additional, Patrucco, Filippo, additional, Patti, Giuseppe, additional, Pau, Alberto, additional, Pedrinelli, Anita Rebecca, additional, Percivale, Ilaria, additional, Ragazzoni, Luca, additional, Re, Roberta, additional, Rigamonti, Cristina, additional, Rizzi, Eleonora, additional, Rognoni, Andrea, additional, Roveta, Annalisa, additional, Salamina, Luigia, additional, Santagostino, Matteo, additional, Saraceno, Massimo, additional, Savoia, Paola, additional, Sciarra, Marco, additional, Schimmenti, Andrea, additional, Scotti, Lorenza, additional, Spinoni, Enrico, additional, Smirne, Carlo, additional, Tarantino, Vanessa, additional, Tillio, Paolo Amedeo, additional, Tonello, Stelvio, additional, Vaschetto, Rosanna, additional, Vassia, Veronica, additional, Zagaria, Domenico, additional, Zavattaro, Elisa, additional, Zeppegno, Patrizia, additional, Zottarelli, Francesca, additional, and Sainaghi, Pier Paolo, additional

Published
2021
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35. Contribution of Atrial Fibrillation to In-Hospital Mortality in Patients With COVID-19

Author

Spinoni, Enrico Guido, primary, Mennuni, Marco, additional, Rognoni, Andrea, additional, Grisafi, Leonardo, additional, Colombo, Crizia, additional, Lio, Veronica, additional, Renda, Giulia, additional, Foglietta, Melissa, additional, Petrilli, Ivan, additional, D’Ardes, Damiano, additional, Sainaghi, Pier Paolo, additional, Aimaretti, Gianluca, additional, Bellan, Mattia, additional, Castello, Luigi, additional, Avanzi, Gian Carlo, additional, Corte, Francesco Della, additional, Krengli, Marco, additional, Pirisi, Mario, additional, Malerba, Mario, additional, Capponi, Andrea, additional, Gallina, Sabina, additional, Pierdomenico, Sante Donato, additional, Cipollone, Francesco, additional, Patti, Giuseppe, additional, Albano, Emanuele, additional, Dianzani, Umberto, additional, Gaidano, Gianluca, additional, Gennari, Alessandra, additional, Gramaglia, Carla, additional, Solli, Martina, additional, Giubertoni, Ailia, additional, Veia, Alessia, additional, Cisari, Carlo, additional, Amedeo Tillio, Paolo, additional, Valletti, Paolo Aluffi, additional, Adesi, Francesco Barone, additional, Barini, Michela, additional, Ferrante, Daniela, additional, De Vecchi, Simona, additional, Santagostino, Matteo, additional, Acquaviva, Antonio, additional, Calzaducca, Elisa, additional, Casciaro, Francesco Giuseppe, additional, Ceruti, Federico, additional, Cittone, Micol Giulia, additional, Di Benedetto, Davide, additional, Gagliardi, Ileana, additional, Giacomini, Greta Maria, additional, Landi, Irene Cecilia, additional, Landi, Raffaella, additional, Manfredi, Giulia Francesca, additional, Pedrinelli, Anita Rebecca, additional, Rigamonti, Cristina, additional, Rizzi, Eleonora, additional, Smirne, Carlo, additional, Vassia, Veronica, additional, Arioli, Roberto, additional, Danna, Pietro, additional, Falaschi, Zeno, additional, Paschè, Alessio, additional, Percivale, Ilaria, additional, Zagaria, Domenico, additional, Beltrame, Michela, additional, Bertoli, Matteo, additional, Galbiati, Alessandra, additional, Gardino, Clara Ada, additional, Gastaldello, Maria Luisa, additional, Via, Valentina Giai, additional, Giolitti, Francesca, additional, Inserra, Ilaria, additional, Labella, Emanuela, additional, Nerici, Ilaria, additional, Gironi, Laura Cristina, additional, Cammarata, Edoardo, additional, Esposto, Elia, additional, Tarantino, Vanessa, additional, Zavattaro, Elisa, additional, Zottarelli, Francesca, additional, Daffara, Tommaso, additional, Ferrero, Alice, additional, Leone, Ilaria, additional, Nuzzo, Alessandro, additional, Baldon, Giulia, additional, Battistini, Sofia, additional, Chirico, Emilio, additional, Lorenzini, Luca, additional, Martelli, Maria, additional, Barbero, Emanuela, additional, Boffano, Paolo, additional, Brucoli, Matteo, additional, Garzaro, Massimiliano, additional, Pau, Alberto, additional, Bertolin, Stephanie, additional, Marzari, Letizia, additional, Avino, Gianluca, additional, Saraceno, Massimo, additional, Morosini, Umberto, additional, Baricich, Alessio, additional, Invernizzi, Marco, additional, Gallo, Silvia, additional, Montabone, Claudia, additional, Padelli, Samuel Alberto, additional, Boglione, Lucio, additional, Patrucco, Filippo, additional, Salamina, Luigia, additional, Baorda, Francesca, additional, Croce, Eleonora, additional, and Giacone, Irene, additional

Published
2021
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36. Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge

Author

Bellan, Mattia, primary, Soddu, Daniele, additional, Balbo, Piero Emilio, additional, Baricich, Alessio, additional, Zeppegno, Patrizia, additional, Avanzi, Gian Carlo, additional, Baldon, Giulia, additional, Bartolomei, Giuseppe, additional, Battaglia, Marco, additional, Battistini, Sofia, additional, Binda, Valeria, additional, Borg, Margherita, additional, Cantaluppi, Vincenzo, additional, Castello, Luigi Mario, additional, Clivati, Elisa, additional, Cisari, Carlo, additional, Costanzo, Martina, additional, Croce, Alessandro, additional, Cuneo, Daria, additional, De Benedittis, Carla, additional, De Vecchi, Simona, additional, Feggi, Alessandro, additional, Gai, Martina, additional, Gambaro, Eleonora, additional, Gattoni, Eleonora, additional, Gramaglia, Carla, additional, Grisafi, Leonardo, additional, Guerriero, Chiara, additional, Hayden, Eyal, additional, Jona, Amalia, additional, Invernizzi, Marco, additional, Lorenzini, Luca, additional, Loreti, Lucia, additional, Martelli, Maria, additional, Marzullo, Paolo, additional, Matino, Erica, additional, Panero, Antonio, additional, Parachini, Elena, additional, Patrucco, Filippo, additional, Patti, Giuseppe, additional, Pirovano, Alice, additional, Prosperini, Pierluigi, additional, Quaglino, Riccardo, additional, Rigamonti, Cristina, additional, Sainaghi, Pier Paolo, additional, Vecchi, Camilla, additional, Zecca, Erika, additional, and Pirisi, Mario, additional

Published
2021
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42. Efficacy of a hip flexion assist orthosis in adults with hemiparesis after stroke

Author

Carda, Stefano, Invernizzi, Marco, Cognolato, Gianluca, Piccoli, Eugenio, Baricich, Alessio, and Cisari, Carlo

Subjects
Stroke (Disease) -- Physiological aspects -- Patient outcomes, Orthopedic equipment and supplies -- Usage, Therapeutics, Physiological -- Methods -- Patient outcomes, Physical therapy -- Methods -- Patient outcomes, Hemiplegia -- Care and treatment -- Physiological aspects, Health
Abstract

Background. During gait, the hip flexors generate 40% of the total power. Nevertheless, no device has been tested extensively for clinical purposes to cope with weakness in the hip flexors in patients with stroke. Objective. The purpose of this study was to assess the efficacy and safety of a newly developed hip flexion assist orthosis in adult patients with hemiparesis after stroke. Design. The study used a prospective, randomized, before-after trial design. The inclusion criteria were hemiparesis resulting from stroke (onset [greater than or equal to]8 weeks); ability to walk, even ff with assistance; and hip flexion weakness (Medical Research Council Scale score [less than or equal to]4). Methods. The main outcome measures were the 10-Meter Walk Test and the Six-Minute Walk Test. Patients also were evaluated with the Trunk Control Test, the Functional Ambulation Categories, the Motricity Index, and hip flexor strength on the Medical Research Council Scale. Sixty-two survivors of stroke were tested in random order with and without the orthosis. Any adverse event associated with its use was recorded. Results. Both the Six-Minute Walk Test and the 10-Meter Walk Test scores improved with the use of the orthosis. A significant negative correlation was found for improvement between scores on the 2 main outcome measures with the orthosis and the Functional Ambulation Categories scores. The improvement in Six-Minute Walk Test scores with the orthosis was related inversely to hip flexor strength. Conclusions. The data showed that the use of a hip flexion assist orthosis can improve gait in patients with poststroke hemiparesis, particularly those with more severe walking impairment., Stroke, the primary cause of adult disability, leads to impairments in mobility and walking. Even though about a third of patients with stroke survive 5 years after the event, mobility [...]

Published
2012
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43. Multifactorial Assessment of Risk of Falling in 753 Post-Menopausal Women: A Multicenter Cross-Sectional Study by the Italian Group for the Study of Metabolic Bone Diseases

Author

Iolascon, Giovanni, primary, de Sire, Alessandro, additional, Calafiore, Dario, additional, Benedetti, Maria Grazia, additional, Cisari, Carlo, additional, Letizia Mauro, Giulia, additional, Migliaccio, Silvia, additional, Nuti, Ranuccio, additional, Resmini, Giuseppina, additional, Gonnelli, Stefano, additional, and Moretti, Antimo, additional

Published
2020
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50. What Is the Role of the Placebo Effect for Pain Relief in Neurorehabilitation? Clinical Implications From the Italian Consensus Conference on Pain in Neurorehabilitation

Author

Castelnuovo, Gianluca, Giusti, Emanuele Maria, Manzoni, Gian Mauro, Saviola, Donatella, Gabrielli, Samantha, Lacerenza, Marco, Pietrabissa, Giada, Cattivelli, Roberto, Maria Spatola, Chiara Anna, Rossi, Alessandro, Varallo, Giorgia, Novelli, Margherita, Villa, Valentina, Luzzati, Francesca, Cottini, Andrea, Lai, Carlo, Volpato, Eleonora, Cavalera, Cesare, Pagnini, Francesco, Tesio, Valentina, Castelli, Lorys, Tavola, Mario, Torta, Riccardo, Arreghini, Marco, Zanini, Loredana, Brunani, Amelia, Seitanidis, Ionathan, Ventura, Giuseppe, Capodaglio, Paolo, D'Aniello, Guido Edoardo, Scarpina, Federica, Brioschi, Andrea, Bigoni, Matteo, Priano, Lorenzo, Mauro, Alessandro, Riva, Giuseppe, Di Lernia, Daniele, Repetto, Claudia, Regalia, Camillo, Molinari, Enrico, Notaro, Paolo, Paolucci, Stefano, Sandrini, Giorgio, Simpson, Susan, Wiederhold, Brenda Kay, Gaudio, Santino, Jackson, Jeffrey B., Tamburin, Stefano, Benedetti, Fabrizio, Agostini, Michela, Alfonsi, Enrico, Aloisi, Anna Maria, Alvisi, Elena, Aprile, Irene, Armando, Michela, Avenali, Micol, Azicnuda, Eva, Barale, Francesco, Bartolo, Michelangelo, Bergamaschi, Roberto, Berlangieri, Mariangela, Berlincioni, Vanna, Berliocchi, Laura, Berra, Eliana, Berto, Giulia, Bonadiman, Silvia, Bonazza, Sara, Bressi, Federica, Brugnera, Annalisa, Brunelli, Stefano, Buzzi, Maria Gabriella, Cacciatori, Carlo, Calvo, Andrea, Cantarella, Cristina, Caraceni, Augusto, Carone, Roberto, Carraro, Elena, Casale, Roberto, Castellazzi, Paola, Castino, Adele, Cerbo, Rosanna, Chiò, Adriano, Ciotti, Cristina, Cisari, Carlo, Coraci, Daniele, Dalla Toffola, Elena, Defazio, Giovanni, De Icco, Roberto, Del Carro, Ubaldo, Dell'Isola, Andrea, De Tanti, Antonio, D'Ippolito, Mariagrazia, Fazzi, Elisa, Ferrari, Adriano, Ferrari, Sergio, Ferraro, Francesco, Formaglio, Fabio, Formisano, Rita, Franzoni, Simone, Gajofatto, Francesca, Gandolfi, Marialuisa, Gardella, Barbara, Geppetti, Pierangelo, Giammò, Alessandro, Gimigliano, Raffaele, Greco, Elena, Ieraci, Valentina, Invernizzi, Marco, Jacopetti, Marco, La Cesa, Silvia, Lobba, Davide, Magrinelli, Francesca, Mandrini, Silvia, Manera, Umberto, Marchettini, Paolo, Marchioni, Enrico, Mariotto, Sara, Martinuzzi, Andrea, Masciullo, Marella, Mezzarobba, Susanna, Miotti, Danilo, Modenese, Angela, Molinari, Marco, Monaco, Salvatore, Morone, Giovanni, Nappi, Rossella, Negrini, Stefano, Pace, BIAGIO ANDREA, Padua, Luca, Pagliano, Emanuela, Palmerini, Valerio, Pazzaglia, Costanza, Pecchioli, Cristiano, Picelli, Alessandro, Porro, CARLO ADOLFO, Porru, Daniele, Romano, Marcello, Roncari, Laura, Rosa, Riccardo, Saccavini, Marsilio, Sacerdote, Paola, Schenone, Angelo, Schweiger, Vittorio, Scivoletto, Giorgio, Smania, Nicola, Solaro, Claudio, Spallone, Vincenza, Springhetti, Isabella, Tassorelli, Cristina, Tinazzi, Michele, Togni, Rossella, Torre, Monica, Traballesi, Marco, Tramontano, Marco, Truini, Andrea, Tugnoli, Valeria, Turolla, Andrea, Vallies, Gabriella, Verzini, Elisabetta, Vottero, Mario, Zerbinati, Paolo, Castelnuovo, Gianluca, Giusti, Emanuele Maria, Manzoni, Gian Mauro, Saviola, Donatella, Gabrielli, Samantha, Lacerenza, Marco, Pietrabissa, Giada, Cattivelli, Roberto, Maria Spatola, Chiara Anna, Rossi, Alessandro, Varallo, Giorgia, Novelli, Margherita, Villa, Valentina, Luzzati, Francesca, Cottini, Andrea, Lai, Carlo, Volpato, Eleonora, Cavalera, Cesare, Pagnini, Francesco, Tesio, Valentina, Castelli, Lory, Tavola, Mario, Torta, Riccardo, Arreghini, Marco, Zanini, Loredana, Brunani, Amelia, Seitanidis, Ionathan, Ventura, Giuseppe, Capodaglio, Paolo, D'Aniello, Guido Edoardo, Scarpina, Federica, Brioschi, Andrea, Bigoni, Matteo, Priano, Lorenzo, Mauro, Alessandro, Riva, Giuseppe, Di Lernia, Daniele, Repetto, Claudia, Regalia, Camillo, Molinari, Enrico, Notaro, Paolo, Paolucci, Stefano, Sandrini, Giorgio, Simpson, Susan, Wiederhold, Brenda Kay, Gaudio, Santino, Jackson, Jeffrey B., Tamburin, Stefano, Benedetti, Fabrizio, Agostini, Michela, Alfonsi, Enrico, Aloisi, Anna Maria, Alvisi, Elena, Aprile, Irene, Armando, Michela, Avenali, Micol, Azicnuda, Eva, Barale, Francesco, Bartolo, Michelangelo, Bergamaschi, Roberto, Berlangieri, Mariangela, Berlincioni, Vanna, Berliocchi, Laura, Berra, Eliana, Berto, Giulia, Bonadiman, Silvia, Bonazza, Sara, Bressi, Federica, Brugnera, Annalisa, Brunelli, Stefano, Buzzi, Maria Gabriella, Cacciatori, Carlo, Calvo, Andrea, Cantarella, Cristina, Caraceni, Augusto, Carone, Roberto, Carraro, Elena, Casale, Roberto, Castellazzi, Paola, Castino, Adele, Cerbo, Rosanna, Chiò, Adriano, Ciotti, Cristina, Cisari, Carlo, Coraci, Daniele, Dalla Toffola, Elena, Defazio, Giovanni, De Icco, Roberto, Del Carro, Ubaldo, Dell'Isola, Andrea, De Tanti, Antonio, D'Ippolito, Mariagrazia, Fazzi, Elisa, Ferrari, Adriano, Ferrari, Sergio, Ferraro, Francesco, Formaglio, Fabio, Formisano, Rita, Franzoni, Simone, Gajofatto, Francesca, Gandolfi, Marialuisa, Gardella, Barbara, Geppetti, Pierangelo, Giammò, Alessandro, Gimigliano, Raffaele, Greco, Elena, Ieraci, Valentina, Invernizzi, Marco, Jacopetti, Marco, La Cesa, Silvia, Lobba, Davide, Magrinelli, Francesca, Mandrini, Silvia, Manera, Umberto, Marchettini, Paolo, Marchioni, Enrico, Mariotto, Sara, Martinuzzi, Andrea, Masciullo, Marella, Mezzarobba, Susanna, Miotti, Danilo, Modenese, Angela, Molinari, Marco, Monaco, Salvatore, Morone, Giovanni, Nappi, Rossella, Negrini, Stefano, Pace, Andrea, Padua, Luca, Pagliano, Emanuela, Palmerini, Valerio, Pazzaglia, Costanza, Pecchioli, Cristiano, Picelli, Alessandro, Porro, Carlo Adolfo, Porru, Daniele, Romano, Marcello, Roncari, Laura, Rosa, Riccardo, Saccavini, Marsilio, Sacerdote, Paola, Schenone, Angelo, Schweiger, Vittorio, Scivoletto, Giorgio, Smania, Nicola, Solaro, Claudio, Spallone, Vincenza, Springhetti, Isabella, Tassorelli, Cristina, Tinazzi, Michele, Togni, Rossella, Torre, Monica, Traballesi, Marco, Tramontano, Marco, Truini, Andrea, Tugnoli, Valeria, Turolla, Andrea, Vallies, Gabriella, Verzini, Elisabetta, Vottero, Mario, Zerbinati, Paolo, and Italian Consensus Conference on Pain in Neurorehabilitation

Subjects
medicine.medical_specialty, Clinical psychology, Consensus conference, Health psychology, Neurorehabilitation, Pain, Placebo, Placebo effect, Neurologi, consensus conference, Analgesic, Neurology, Neurology (clinical), Context (language use), Review, Settore M-PSI/08 - PSICOLOGIA CLINICA, helath psychology, lcsh:RC346-429, 03 medical and health sciences, 0302 clinical medicine, health psychology, Fibromyalgia, medicine, pain, 030212 general & internal medicine, lcsh:Neurology. Diseases of the nervous system, neurorehabilitation, Postherpetic neuralgia, business.industry, medicine.disease, Complex regional pain syndrome, Neuropathic pain, placebo, Physical therapy, placebo effect, clinical psychology, business, 030217 neurology & neurosurgery, Neuroscience
Abstract

Background: It is increasingly acknowledged that the outcomes of medical treatments are influenced by the context of the clinical encounter through the mechanisms of the placebo effect. The phenomenon of placebo analgesia might be exploited to maximize the efficacy of neurorehabilitation treatments. Since its intensity varies across neurological disorders, the Italian Consensus Conference on Pain in Neurorehabilitation (ICCP) summarized the studies on this field to provide guidance on its use. Methods: A review of the existing reviews and meta-analyses was performed to assess the magnitude of the placebo effect in disorders that may undergo neurorehabilitation treatment. The search was performed on Pubmed using placebo, pain, and the names of neurological disorders as keywords. Methodological quality was assessed using a pre-existing checklist. Data about the magnitude of the placebo effect were extracted from the included reviews and were commented in a narrative form. Results: 11 articles were included in this review. Placebo treatments showed weak effects in central neuropathic pain (pain reduction from 0.44 to 0.66 on a 0-10 scale) and moderate effects in postherpetic neuralgia (1.16), in diabetic peripheral neuropathy (1.45), and in pain associated to HIV (1.82). Moderate effects were also found on pain due to fibromyalgia and migraine; only weak short-term effects were found in complex regional pain syndrome. Confounding variables might have influenced these results. Clinical implications: These estimates should be interpreted with caution, but underscore that the placebo effect can be exploited in neurorehabilitation programs. It is not necessary to conceal its use from the patient. Knowledge of placebo mechanisms can be used to shape the doctor-patient relationship, to reduce the use of analgesic drugs and to train the patient to become an active agent of the therapy. Background: It is increasingly acknowledged that the outcomes of medical treatments are influenced by the context of the clinical encounter through the mechanisms of the placebo effect. The phenomenon of placebo analgesia might be exploited to maximize the efficacy of neurorehabilitation treatments. Since its intensity varies across neurological disorders, the Italian Consensus Conference on Pain in Neurorehabilitation (ICCP) summarized the studies on this field to provide guidance on its use. Methods: A review of the existing reviews and meta-analyses was performed to assess the magnitude of the placebo effect in disorders that may undergo neurorehabilitation treatment. The search was performed on Pubmed using placebo, pain, and the names of neurological disorders as keywords. Methodological quality was assessed using a pre-existing checklist. Data about the magnitude of the placebo effect were extracted from the included reviews and were commented in a narrative form. Results: 11 articles were included in this review. Placebo treatments showed weak effects in central neuropathic pain (pain reduction from 0.44 to 0.66 on a 0-10 scale) and moderate effects in postherpetic neuralgia (1.16), in diabetic peripheral neuropathy (1.45), and in pain associated to HIV (1.82). Moderate effects were also found on pain due to fibromyalgia and migraine; only weak short-term effects were found in complex regional pain syndrome. Confounding variables might have influenced these results. Clinical implications: These estimates should be interpreted with caution, but underscore that the placebo effect can be exploited in neurorehabilitation programs. It is not necessary to conceal its use from the patient. Knowledge of placebo mechanisms can be used to shape the doctor-patient relationship, to reduce the use of analgesic drugs and to train the patient to become an active agent of the therapy.

Published
2018

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