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Guided bone regeneration (GBR) requires a tension-free flap without damaging the collateral circulation in order to secure better surgical outcomes. Topographic knowledge regarding the neurovascular bundles in the posterior aspect of the mandible can prevent complications during lingual flap design. The lingual branch (LB) of the inferior alveolar or maxillary arteries is not sufficiently illustrated or described in the literature. Nevertheless, it has an intimate relationship with the lingual nerve (LN) during ridge augmentation and implant-related posterior mandible surgery. Therefore, this study aimed to clarify the morphology and topography of the LB related to GBR surgeries. In the present human cadaveric study, the LB was analyzed in 12 hemimandibles using latex injection and corrosion casting. Two types of LB were identified based on their origin and course. The LB was found in a common connective tissue sheath close to the LN. The LB assembled several anastomoses on the posterior lingual aspect of the mandible and retromolar area. The LB acted as an anatomical landmark in identifying LN at the posterior lingual aspect of the mandible. [ABSTRACT FROM AUTHOR]

The southern tropical Indian Ocean (TIO) displays large mixed layer salinity (MLS) variation. Circulation in this region is governed by the Indian Ocean tropical gyre (IOTG), where the source water proportion and associated mixing remain unclear. Particles integrating into the IOTG and entering the central southern TIO originate from the Bay of Bengal, Malacca Strait, western Indian Ocean, and Indonesian Throughflow. Surprisingly, cross‐equatorial advection is particularly important, implying a significant connection between both the Bay of Bengal and the South China Sea via Malacca Strait into the southern TIO. The anomalous anticlockwise circulation weakens the IOTG during positive Indian Ocean Dipole (IOD). An opposite pattern is observed in the negative IOD. A particle experiment reveals that water masses are modulated by the anomalous circulation that drives the redistribution of MLS by changing the proportion of the different source waters. This represents a potential predictability for the southern TIO MLS variability. Plain Language Summary: The southern tropical Indian Ocean (TIO) has a relatively large salinity variability that appears isolated from the salinity variability associated with the exchange between the Bay of Bengal and the Arabian Sea. This variation can be attributed to the advection within the Indian Ocean tropical gyre (IOTG). The IOTG experiences a strong seasonal to interannual variation due to the monsoon wind. In the mean state, the water masses originating from the Bay of Bengal, Malacca Strait, Indonesian Throughflow, and western equatorial Indian Ocean integrate into the IOTG and merge into the southern central TIO. Year to year variability in the circulation affects the magnitude of the IOTG. As a result, the proportion of the different source waters change and modulate the surface salinity pattern. These findings contribute to a better understanding of the salinity‐induced variability of oceanic stratification and the large‐scale regional climate modes. Key Points: Water masses mostly originating from the northern hemisphere mix to cause large salinity variability in the southern tropical Indian OceanThe mixed layer salinity of the central southern tropical Indian Ocean lags the Dipole Mode Index by 4 monthsA particle experiment shows anomalous tropical Indian Ocean circulation modulates mixed layer salinity by changing source water proportions [ABSTRACT FROM AUTHOR]

This study reports the development and evaluation of yttrium-90 (90Y) radiolabeled silica-coated iron oxide (SiO 2 -Fe 3 O 4) resin microspheres for potential theranostic application in cancer radiation therapy. Iron oxide nanoparticles of average diameter 29.7 nm were synthesized via optimized co-precipitation and displayed superparamagnetic behavior ideal for MRI. Aminosilane surface functionalization enabled covalent conjugation of 1 mmol/g DTPA/DOTA chelators for labeling 2 mCi 90Y per 150 μg nanoparticles with 92 % efficiency when incubated for 45 mins at pH 5.5 and 50°C. In vitro stability assays in buffers and human serum showed excellent 90Y retention (>95 %) up to 48 hours. In vivo biodistribution in Wistar rats revealed extended nanoparticle circulation half-life of 5.2 hours and peak exposure of 22.4 %ID/g compared to rapid clearance of unconjugated 90Y chloride within 1 hour. Complete renal recovery by 72 hours and minimal bone accumulation (<2 %) proves in vivo stability and biocompatibility of the 90Y-radiolabeled theranostic platform. [ABSTRACT FROM AUTHOR]

In much anthropological reflection on value creation through objects, value is conceptualized as created in circulation. Yet objects' social lives are punctuated by periods of waiting as much as they are by movement. Waiting can thus be theorized and examined as a critical pause in the circulation of objects, one that enables their value transformation and creation via social actors, institutions, and valuation processes. Demonstrating this can be accomplished ethnographically by following the consignment, exhibition, and sale of a group of objects—in this case by the artist Maqbool Fida Husain via a Mumbai art gallery. As objects wait, the art world turns around them, setting valuation and other value‐making processes in motion. This moment of waiting is precisely when our methodological and analytical gaze should turn to the object's social relations and to the collective activities of the art world. [ABSTRACT FROM AUTHOR]

In the surfzone, breaking‐wave generated eddies and vortices transport material along the coast and offshore to the continental shelf, providing a pathway from land to the ocean. Here, surfzone vorticity is investigated with unique field observations obtained during a wide range of wave and bathymetric conditions on an Atlantic Ocean beach. Small spatial‐scale [O(10 m)] vorticity estimated with a 5 m diameter ring of 14 current meters deployed in ∼2 m water depth increased as the directional spread of the wave field increased. Large spatial‐scale [O(100 m)] vorticity calculated from remote sensing estimates of currents across the surfzone along 200 m of the shoreline increased as alongshore bathymetric variability (channels, bars, bumps, holes) increased. For all bathymetric conditions, large‐scale vorticity in the inner surfzone was more energetic than in the outer surfzone. Plain Language Summary: Circular, rotating flow features, such as eddies, swirls, and vortices mix and disperse material throughout the ocean. Here, circular flow features that can transport sediments, pollutants, and biota from the shore to the continental shelf were investigated using field observations from a 5 m diameter ring of current meters in 2 m depth and from tracking naturally occurring ocean foam visible in optical images of the surfzone (where waves break) spanning 200 m of the coast. The observations show that small‐scale flow patterns become more energetic as ocean waves arrive from a wider range of directions and that large‐scale flow features become more energetic as the seafloor becomes more nonuniform (including holes and channels). Key Points: Surfzone vorticity is estimated for the first time with unique field observations within, across, and along the surfzoneIn situ observations show that small‐scale vorticity injected by breaking waves increases with wave directional spreadRemotely sensed observations show large‐spatial scale vorticity increases as bathymetry becomes more alongshore inhomogeneous [ABSTRACT FROM AUTHOR]

This study analyzed the horizontal and vertical distribution characteristics of temperature and salinity in the central and eastern regions of the Beibu Gulf, based on conductivity measurements in summer 2022, temperature, and depth (CTD) measurement data from the Sino–Vietnamese cooperative project "Demonstration Study on Ecological Protection and Management in Typical Bays: Seasonal Survey of the Beibu Gulf". Furthermore, the study utilized the computational results from the numerical Finite-Volume Coastal Ocean Model (FVCOM) to elucidate the intrinsic patterns that formed the temperature and salinity distribution characteristics in August 2022 from both thermodynamic and dynamic perspectives. The circulation in the Beibu Gulf drives external seawater to move northward from the bay mouth. During this movement, numerous upwelling areas are created by lateral Ekman transport. The formation of different scales of cyclonic and anticyclonic vortices and current convergence zones is influenced by topography, runoff, and the water flux from the Qiongzhou Strait, which are key factors in the formation of upwelling and downwelling. The surface circulation in August 2022 significantly differed from the 20-year average surface circulation, with an influx of 1.15 × 104 m3/s more water entering the Beibu Gulf compared to the multi-year average. The water flux from the Qiongzhou Strait is a critical factor affecting the circulation patterns in the Beibu Gulf. The northeastern waters of the Beibu Gulf are characterized by current convergence zones, where extensive upwelling occurs. The rich nutrient salts in these areas promote the reproduction and growth of phytoplankton and zooplankton, making this the most favorable ecological environment in the Beibu Gulf and serving as a natural reserve for fisheries, coral reefs, dugongs, and Bryde's whales. [ABSTRACT FROM AUTHOR]

Scholars of the infrastructural turn have generally described infrastructure in relation to modernity and modernity in terms of the Enlightenment highlighting the association between circulation and progress in Enlightenment thought as infrastucture's conceptual ground. This essay questions this periodization of infrastructural modernity by exploring the case of a late-sixteenth-century road project in colonial Mexico which formed part of a global assemblage of infrastructures that wove together the emerging racial capitalist world system. Building on the work of Nancy Fraser it proposes an alternative approach to periodizing infrastructural modernity that can distinguish and track transformations between historical regimes of accumulation. [ABSTRACT FROM AUTHOR]

This essay introduces our special issue by arguing that the concept of infrastructure can help us better understand eighteenth-century culture and history even if the word did not exist in that period. It shows moreover how scholars of the eighteenth-century world can contribute to the burgeoning field of infrastructure studies. [ABSTRACT FROM AUTHOR]

This article concerns the so-called irrigation system in the Timaeus 's biology (77a–81e), which replenishes our body's tissues with resources from food delivered as blood. I argue that this system functions mainly by the natural like-to-like motion of the elements and that the circulation of blood is an important case study of Plato's physics. We are forced to revise the view that the elements attract their like. Instead, similar elements merely tend to coalesce with each other in virtue of their tactile features as the atomists describe. The notion of attraction is replaced with this notion of mere coalescence. I begin by outlining how blood is made from food. I then argue that an understanding of health and disease compels us to read Plato as if he were an atomist and to abandon the popular scholarly interpretations according to which the elements attract each other. [ABSTRACT FROM AUTHOR]

Copyright of Online Journal of Art & Design is the property of Online Journal of Art & Design and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Drought, which is severe and recurring in Northern China, is the most significant meteorological disaster on a worldwide scale. However, a definitive conclusion has not yet been reached on the multi-scale drought features in Northern China under a warming context. Drought is affected by several circulation-related variables and a deeper scientific comprehension of their synergistic effects is required. This research addresses the spatiotemporal aspects of summer drought and its causes in the northern drought-prone belt of China (NDPB), based on meteorological observation and data reanalysis. The primary findings indicate that the NDPB is very vulnerable to drought, with the uniform mode being the region's most significant spatial mode associated with summer droughts. Inter-annual variations are the primary cause of the summer drought in the NDPB when considering multi-scale changes. Regional drought has typically declined during this century because of the effect of multi-decadal scale changes, which cannot be disregarded. Considering the circulation background field, during summer drought years in the NDPB, the South Asian high is weaker and moves eastward, while the high-level westerly jet is weaker and more northerly. From Lake Baikal to Northern China, there is an anomalous anticyclonic circulation, and the mid-level subtropical high in the western Pacific is more southerly and easterly. As a result, the NDPB is governed by the unusual northerly circulation. The Mongolian and northeastern surface cyclone activity is decreasing, the low-level warm and humid airflow is feeble, and the NDPB is not experiencing anomalous water vapor transport. In the high-, middle-, and low-level arrangement, the NDPB circulations diverge at low levels and converge at high levels--unusual sinking in the vertical field results in regular droughts. Multiple circulation parameters on inter-annual, inter-decadal, and multi-decadal scales interact synergistically to impact summer droughts in NDPB. However, the synergistic elements that mainly impact various timescales differ. They are primarily influenced by northerly circulation, westerly winds, and the combined effect of the South Asian summer monsoon on inter-annual timescales. The combined impact of the upper westerly winds, northerly circulation, and East Asian, South Asian, and plateau summer monsoons significantly influences their inter-decadal timescales. The westerly winds, northerly circulation, and East Asian, plateau summer monsoons are the primary multi-decadal factors. [ABSTRACT FROM AUTHOR]

The emergence of SARS-CoV-2 and the non-pharmacological interventions adopted to counter its spread appear to have led to changes in the normal circulation and seasonality of respiratory viruses. Our study aims to investigate changes related to the circulation of respiratory viruses, not SARS-CoV-2, among hospitalized patients in Perugia, Central Italy, between 2019 and 2023. The samples were collected from individuals who went to the emergency room (ER) or were hospitalized and analyzed using a molecular multiplex test. The results underline that non-pharmaceutical interventions altered the typical seasonal circulation patterns of different respiratory viruses. Those mostly affected were enveloped viruses like influenza viruses that disappeared in 2021; the least impact was recorded for Rhinovirus, which was detected during the pandemic period, maintaining the same seasonality observed in the pre-pandemic period although with a reduction in the number of positive samples. Our data underline the importance of the continuous monitoring of these viruses, especially to understand the timing with which prevention measures, not only non-pharmacological interventions but also the equipment of vaccine doses and monoclonal antibodies, should be adopted to reduce their circulation, particularly in the population at risk of developing severe forms of lower respiratory tract infection. [ABSTRACT FROM AUTHOR]

Cities are so complex that we constantly build models to represent them, understand them and attempt to plan them. Models represent a middle ground between the singular configurations of cities and universal theories. This is what makes them valuable and prone to circulate (between places, institutions and languages) and evolve to adapt to new ideas, local conditions and/or other models. When it comes to analytical urban models (i.e. analytical representations of cities developed to study or simulate part of their structure or dynamics), there is a lack of academic understanding regarding how context and circulation affect their content, use and interpretation. What happens to analytical urban models and their reception during their circulation across geographical and disciplinary boundaries? How have different academic disciplines interacted with, contributed to and been influenced by analytical urban models? What are the consequences of urban models' mobility for our understanding of cities? In this article, we employ the policy mobilities framework to analyse the circulation of analytical urban models. We use six canonical models as case studies to determine how their assumptions came about and how these models have circulated across different domains of policy and application by using biographical information and model analysis. The first contribution of the article is to demonstrate by example that our hypothesis regarding the influence of context is consistent. We also show that highly transferable/mobile models share common characteristics relating to contingent factors such as their creators' biographies, institutional context and the traditional markers of power relations. [ABSTRACT FROM AUTHOR]

A holistic review is given of the Southern Ocean dynamic system, in the context of the crucial role it plays in the global climate and the profound changes it is experiencing. The review focuses on connections between different components of the Southern Ocean dynamic system, drawing together contemporary perspectives from different research communities, with the objective of closing loops in our understanding of the complex network of feedbacks in the overall system. The review is targeted at researchers in Southern Ocean physical science with the ambition of broadening their knowledge beyond their specific field, and aims at facilitating better‐informed interdisciplinary collaborations. For the purposes of this review, the Southern Ocean dynamic system is divided into four main components: large‐scale circulation; cryosphere; turbulence; and gravity waves. Overviews are given of the key dynamical phenomena for each component, before describing the linkages between the components. The reviews are complemented by an overview of observed Southern Ocean trends and future climate projections. Priority research areas are identified to close remaining loops in our understanding of the Southern Ocean system. Plain Language Summary: The United Nations has identified 2021–2030 as the Decade of Ocean Science, with a goal to improve predictions of ocean and climate change. Improved understanding of the Southern Ocean is crucial to this effort, as it is the central hub of the global ocean. The Southern Ocean is the formation site for much of the dense water that fills the deep ocean, sequesters the majority of anthropogenic heat and carbon, and controls the flux of heat to Antarctica. The large‐scale circulation of the Southern Ocean is strongly influenced by interactions with sea ice and ice shelves, and is mediated by smaller scale processes, including eddies, waves, and mixing. The complex interplay between these dynamic processes remains poorly understood, limiting our ability to understand, model and predict changes to the Southern Ocean, global climate and sea level. This article provides a holistic review of Southern Ocean processes, connecting the smallest scales of ocean mixing to the global circulation and climate. It seeks to develop a common language and knowledge‐base across the Southern Ocean physical science community to facilitate knowledge‐sharing and collaboration, with the aim of closing loops on our understanding of one of the world's most dynamic regions. Key Points: Contemporary perspectives are reviewed on the different components of the Southern Ocean dynamic system from distinct research communitiesKey connections between different components of Southern Ocean dynamics are highlightedCross‐cutting priorities for future Southern Ocean physical science are identified [ABSTRACT FROM AUTHOR]

Innate lymphoid cells (ILCs) are a group of lymphocytes that are devoid of antigen-specific receptors and are mainly found in tissues. The subtypes ILC1, 2, and 3 mirror T-cell functionality in terms of cytokine production and expression of key transcription factors. Although the majority of ILCs are found in tissue (tILCs), they have also been described within the circulation (cILCs). As a result of their better accessibility and putative prognostic value, human cILCs are getting more and more attention in clinical research. However, cILCs are in many aspects functionally distinct from their tILC counterparts. In fact, from the 3 ILC subsets found within the circulation, only for cILC2s could a clear functional correspondence to their tissue counterparts be established. Indeed, cILC2s are emerging as a major driver of allergic reactions with a particular role in asthma. In contrast, recent studies revealed that cILC1s and cILC3s are predominantly in an immature state and constitute progenitors for natural killer cells and ILCs, respectively. We provide an overview about the phenotype and function of the different cILC subtypes compared to tILCs in health and disease, including transcriptomic signatures, frequency dynamics, and potential clinical value. Furthermore, we will highlight the dynamics of the NKp44+ ILC3 subset, which emerges as prognostic marker in peripheral blood for inflammatory bowel disease and leukemia. [ABSTRACT FROM AUTHOR]

Copyright of PLANARCH - Design & Planning Research is the property of Ataturk University Coordinatorship of Scientific Journals and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Brain organoids, three-dimensional cell structures derived from pluripotent stem cells, closely mimic key aspects of the human brain in vitro, providing a powerful tool for studying neurodevelopment and disease. The neuroectodermal induction protocol employed for brain organoid generation primarily gives rise to the neural cellular component but lacks the vital vascular system, which is crucial for the brain functions by regulating differentiation, migration, and circuit formation, as well as delivering oxygen and nutrients. Many neurological diseases are caused by dysfunctions of cerebral microcirculation, making vascularization of human brain organoids an important tool for pathogenetic and translational research. Experimentally, the creation of vascularized brain organoids has primarily focused on the fusion of vascular and brain organoids, on organoid transplantation in vivo, and on the use of microfluidic devices to replicate the intricate microenvironment of the human brain in vitro. This review summarizes these efforts and highlights the importance of studying the neurovascular unit in a forward-looking perspective of leveraging their use for understanding and treating neurological disorders. [ABSTRACT FROM AUTHOR]

Poor maternal nutrition during gestation negatively affects offspring growth and metabolism. To evaluate the impact of maternal nutrient restriction and realimentation on metabolism in the fetal liver, skeletal muscle, and circulation, on day 50 of gestation, ewes (n = 48) pregnant with singletons were fed 100% (CON) or 60% (RES) of requirements until day 90 of gestation, when a subset of ewes (n = 7/treatment) were euthanized, and fetal samples were collected. The remaining ewes were maintained on a current diet (CON-CON, n = 6; RES-RES, n = 7) or switched to an alternative diet (CON-RES, RES-CON; n = 7/treatment). On day 130 of gestation, the remaining ewes were euthanized, and fetal samples were collected. Fetal liver, longissimus dorsi (LD), and blood metabolites were analyzed using LC-MS/MS, and pathway enrichment analysis was conducted using MetaboAnalyst. Then, 600, 518, and 524 metabolites were identified in the liver, LD, and blood, respectively, including 345 metabolites that were present in all three. Nutrient restriction was associated with changes in amino acid, carbohydrate, lipid, and transulfuration/methionine metabolic pathways, some of which were alleviated by realimentation. Fetal age also affected metabolite abundance. The differential abundance of metabolites involved in amino acid, methionine, betaine, and bile acid metabolism could impact fetal epigenetic regulation, protein synthesis, lipid metabolism, and signaling associated with glucose and lipid metabolism. [ABSTRACT FROM AUTHOR]

This study reports the development and evaluation of yttrium-90 (90Y) radiolabeled silica-coated iron oxide (SiO2-Fe3O4) resin microspheres for potential theranostic application in cancer radiation therapy. Iron oxide nanoparticles of average diameter 29.7 nm were synthesized via optimized co-precipitation and displayed superparamagnetic behavior ideal for MRI. Aminosilane surface functionalization enabled covalent conjugation of 1 mmol/g DTPA/DOTA chelators for labeling 2 mCi 90Y per 150 μg nanoparticles with 92 % efficiency when incubated for 45 mins at pH 5.5 and 50°C. In vitro stability assays in buffers and human serum showed excellent 90Y retention (>95 %) up to 48 hours. In vivo biodistribution in Wistar rats revealed extended nanoparticle circulation half-life of 5.2 hours and peak exposure of 22.4 %ID/g compared to rapid clearance of unconjugated 90Y chloride within 1 hour. Complete renal recovery by 72 hours and minimal bone accumulation (

To improve the aerodynamic efficiency of the aircraft, the article focuses on optimizing the L/D ratio through postponement of flow separation. Elevating the L/D ratio leads to diminished drag and delays stall occurrence at high angles of attack (α). The wing geometry adopts NACA 6-digit airfoils, specifically NACA 63418 and NACA 63415. Various aerodynamic devices are explored for their ability to defer flow separation, with passive aerodynamic devices being the prevalent choice. The primary goal of the research is to integrate rotational thin wire elements into the aerodynamic components of the wing, aiming to diminish drag, amplify lift, and enhance overall aerodynamic performance. The analysis spans a range of α, from 0o to 20o. The study encompasses two scenarios: one without the incorporation of aerodynamic devices and the other with their implementation. Comparative analyses of increases in CL and reductions in CD, with notable improvements observed at a 15o angle of attack, 28.47% increase in CL and 15.07% decrease in CD. Furthermore, the improved performance in the CL/CD, which increases substantially in stall conditions, thereby demonstrating the potential of these aerodynamic modifications to enhance overall aircraft performance.

People's ability to perceive space is a consequence of their perception bonding with their surroundings, which allows them to communicate with space. Individuals see the physical components of the environment first, and then their behavior is shaped by their perceptions. People use the physical components of spaces as a point of reference when they are wayfinding in the circulation areas that link the spaces. In this context, users become stressed and lose time when navigating the circulation areas of large, complex buildings, which discourages them from using the space. The purpose of this study is to identify the colors and textures that influence how well people navigate around the circulation areas of healthcare facilities. The digital environment was used to model the Konya City Hospital's circulation area, which was identified as the sample area. A route was made, and the animation and three-dimensional visuals were produced based on the variables. Memorability and orientation decision levels were assessed in the context of wayfinding using the survey technique. As a result of the survey conducted on a total of 399 people, it was analyzed that people remembered the orange color and wood-textured surface coverings and requested orientation.

Vinen’s vibrating wire experiment detected quantized vortices in superfluid 4He, with the anticipated circulation quantum h/m. In addition to this main result, Vinen used his data to propose other properties and behaviors of vortices, which are revisited here. Subsequent work confirmed that non-quantized values occur when vortices cover only part of the wire’s length and that the size of the covered section can change easily. Any motion of the detached portion of the vortex induces changes in the circulation around the wire, which provides a means of tracking the free vortex. Particularly distinctive signatures correspond to a circular motion of the vortex through the cell and to Kelvin waves along the free vortex. Another issue, the lack of stability of multi-quantum states, can also be explained through simple arguments, in which the possibility of a partially detached vortex again plays a key role. Vibrating wire measurements descended from Vinen’s continue to probe superfluid flows.

To improve the aerodynamic efficiency of the aircraft, the article focuses on optimizing the L/D ratio through postponement of flow separation. Elevating the L/D ratio leads to diminished drag and delays stall occurrence at high angles of attack (α). The wing geometry adopts NACA 6-digit airfoils, specifically NACA 63418 and NACA 63415. Various aerodynamic devices are explored for their ability to defer flow separation, with passive aerodynamic devices being the prevalent choice. The primary goal of the research is to integrate rotational thin wire elements into the aerodynamic components of the wing, aiming to diminish drag, amplify lift, and enhance overall aerodynamic performance. The analysis spans a range of α, from 0° to 20°. The study encompasses two scenarios: one without the incorporation of aerodynamic devices and the other with their implementation. Comparative analyses of increases in CL and reductions in CD, with notable improvements observed at a 15o angle of attack, 28.47% increase in CL and 15.07% decrease in CD. Furthermore, the improved performance in the CL/CD, which increases substantially in stall conditions, thereby demonstrating the potential of these aerodynamic modifications to enhance overall aircraft performance. [ABSTRACT FROM AUTHOR]

Objective: This review aims to explore the role of physical activity as an integral palliative care strategy in managing deep vein thrombosis (DVT), providing a comprehensive analysis and practical insights for clinicians. Methods: A thorough review of relevant literature was conducted, encompassing studies, clinical trials, and expert opinions that examine the relationship between physical activity and palliative care from the perspective of DVT. The search included databases such as PubMed, PEDro, and Scopus, with an emphasis on articles published within the last decade. Results: The review highlights the multifaceted benefits of incorporating physical activity into the palliative care approach for individuals with DVT. Physical activity has been effective in enhancing overall well-being, alleviating symptoms, and contributing to the holistic management of DVT-related complications. In addition, the literature underscores the importance of personalized exercise regimens tailored to the patient’s condition, ensuring safety and effectiveness. Conclusion: This comprehensive review underscores the significance of physical activity as a pivotal element in palliative care for individuals with DVT. Integrating personalized exercise regimens into the management strategy offers a holistic approach that addresses the physical and psychosocial aspects of DVT. As clinicians navigate the complexities of DVT palliative care, a thorough and timely incorporation of physical activity can significantly contribute to enhancing the overall quality of life for affected individuals.

Abstract Background Despite dengue virus (DENV) outbreak in Gabon a decade ago, less is known on the potential circulation of DENV serotypes in the country. Previous studies conducted in some areas of the country, are limited to hospital-based surveys which reported the presence of some cases of serotype 2 and 3 seven years ago and more recently the serotype 1. As further investigation, we extend the survey to the community of Moyen Ogooué region with the aim to assess the presence of the dengue virus serotypes, additionally to characterize chikungunya (CHIKV) infection and describe the symptomatology associated with infections. Method A cross-sectional survey was conducted from April 2020 to March 2021. The study included participants of both sexes and any age one year and above, with fever or history of fever in the past seven days until blood collection. Eligible volunteers were clinically examined, and blood sample was collected for the detection of DENV and CHIKV using RT-qPCR. Positive samples were selected for the target sequencing. Results A total of 579 volunteers were included. Their mean age (SD) was 20 (20) years with 55% of them being female. Four cases of DENV infection were diagnosed giving a prevalence of 0.7% (95%CI: 0.2–1.8) in our cohort while no case of CHIKV was detected. The common symptoms and signs presented by the DENV cases included fatigue, arthralgia myalgia, cough, and loss of appetite. DENV-1was the only virus detected by RT-qPCR. Conclusion Our results confirm the presence of active dengue infection in the region, particularly DENV-1, and could suggest the decline of DENV-2 and DENV-3. Continuous surveillance remains paramount to comprehensively describe the extent of dengue serotypes distribution in the Moyen-Ogooué region of Gabon.

Varicose veins typically occur in the lower limbs, caused by valvular insufficiency leading to the swelling and tortuosity of subcutaneous veins. Although rare in the upper limbs, they can be successfully diagnosed and treated. Rare causes include congenital vascular anomalies like Klippel-Trenaunay syndrome and Parkes Weber syndrome, characterised by Arteriovenous (AV) fistulae. Subclavian vein thrombosis-induced venous outflow obstruction is another uncommon cause. Diagnosis involves a thorough history taking with clinical examination, often supplemented by investigations. Invasive procedures are rarely necessary but may be used in unique cases to define the pathology further. Treatment for upper limb varicose veins closely mirrors lower limb approaches. The stab-avulsion technique combined with stripping of lengthier sections yields outstanding cosmetic and functional results. Surgical ligation with stripping effectively eliminates varicosities with a low risk of recurrence. Sclerosing agents like Sodium Tetradecyl Sulphate and Polidocanol are substitutes for surgery. In cases of varicosities resulting from upper limb arteriovenous fistulae, surgical intervention involving ligation of the distal venous limb or division of the fistula is the standard approach. In summary, while upper limb varicose veins are exceptionally rare, they can be accurately diagnosed and effectively treated with surgical interventions similar to lower limb varicose veins.

Marine‐terminating glacier fjords play a central role in the transport of oceanic heat toward ice sheets, regulating their melt. Mixing processes near glacial termini are key to this circulation but remain poorly understood. We present new summer measurements of circulation and mixing near a marine‐terminating glacier with active sub‐glacial discharge. 65% of the fjord's vertical overturning circulation is driven by the buoyant plume, however we newly report intense vertical and horizontal mixing in the plume's horizontal spreading phase, accounting for the remaining 35%. Buoyant plume theory supports 2%–5% of total glacial melt. Thus, most of the heat associated with vertical overturing short‐circuits the glacial front. We find however that turbulence in the horizontal spreading phase redistributes the short‐circuited heat back into the surface waters of the near‐glacial zone. Our findings highlight the need for further research on the complex mixing processes that occur near the glacier terminus. Plain Language Summary: Melting of glacial ice is the single largest contributor to global sea‐level rise. Many glaciers flow into the ocean where the near‐vertical ice wall is bathed in relatively warm sea water. Freshwater from ice surface melting seeps down through cracks and crevasses in the glacier to be discharged at the base of the ice wall, many tens to hundreds of meters below the sea surface. This fresh water rises from the depths as a highly turbulent plume, drawing in and pushing upwards the surrounding seawater, eventually spreading horizontally as a mixture of fresh discharge and mixed‐in seawater. Few measurements exist in the dangerous zone where iceberg often calve. Using data from a robotic platform we show that the vertical rise and the horizontal spreading of fresh water both play important roles in the total ocean‐induced melting of the glacial face in this type of system. Key Points: Entrainment into the buoyant plume drives ∼65% of fjord vertical overturning circulationIntense turbulent mixing in the horizontal spreading phase of the plume drives the remaining ∼35%95%–98% of the heat in the rising plume short‐circuits the glacier, to be redistributed into glacial proximal waters by horizontal mixing [ABSTRACT FROM AUTHOR]

Mid‐tropospheric elevated moist layers (EMLs) near the melting level have been found in various regional observational studies in the tropics. Recently, a preponderance of EMLs in the presence of aggregated convection was found in cloud resolving simulations of radiative convective equilibrium (RCE), highlighting a significant circulation coupling. Here, we present global monthly EML occurrence rates based on reanalysis, yielding a broader view on where and when EMLs occur in the real world. Over the Atlantic, EML occurrence follows a seasonal cycle that maximizes in summer, aligning with maximized ITCZ intensity and organization. Resembling the results in RCE, the large‐scale circulation over the Atlantic shifts from a deep overturning in January to a bottom‐heavy circulation in July. While EMLs embedded in the July cross‐equatorial Hadley cell are found to be sourced from the ITCZ, EMLs north of the ITCZ emerge from the strongly sheared zonal flow over West Africa. Plain Language Summary: In the vicinity of thunderstorms, the atmosphere is typically dry enabling the moist boundary layer top to radiatively cool efficiently. This yields subsidence and surface divergence that is thought to feed moist air near the surface into the thunderstorm, favoring convective aggregation. Recent idealized simulations have shown that more aggregated convection is associated with an enhanced outflow of moist air in the mid‐troposphere that inhibits boundary layer cooling and drives an overturning circulation above the boundary layer. Here, we provide a first observational quantification of mid‐tropospheric moist layer occurrence globally on a multi‐year timescale. We find a significant seasonal cycle over the Atlantic with a maximum in summer, aligning with peak convective activity and organization of the Atlantic rainbelt. We show that the Atlantic overturning circulation becomes vertically constrained by the moist layers (EMLs), similar to the idealized simulations. EMLs embedded in the Atlantic Hadley circulation are likely sourced from convection within the Atlantic rainbelt, while EMLs over the northern sub‐tropical Atlantic emerge from zonal wind shear within the West African monsoon system. Key Points: Moist layers (EMLs) are ubiquitous around the tropical rain belts and their occurrence is subject to a strong seasonal cycle over the AtlanticEMLs near the Atlantic summer ITCZ are associated with a more bottom‐heavy Hadley circulationThe Atlantic summer ITCZ detrains mid‐level moisture to the south while to the north EMLs are sourced from West Africa [ABSTRACT FROM AUTHOR]

If we are to achieve climate change targets, transport systems need to transform. This article is concerned with the prospects of challenging the regime of automobility in urban areas. It employs a governmentality framework, alongside theories of automobility, in order to analyse mobility governmentalities in Gothenburg, Sweden. Gothenburg is an interesting case in the context of reducing car use given its identity as a 'car city.' Despite this, Gothenburg has high ambitions in terms of reducing car traffic. Reaching these goals are however associated with challenges: prognoses predict a continued increase in car traffic, and political acceptance is viewed as an obstacle. The article's findings are based on semi-structured interviews with public officials and stakeholders, zooming in on (1) conflicting spatialities and temporalities (2) competing logics of circulation and pace and (3) mobility imaginaries of the (im)possible. We argue that while there are new logics entering urban mobility governmentalities as an effect of the climate transition, their possibilities to affect material change are confined because the movement and circulation of 'people and things,' ultimately represented by the private car, are closely tied to the way that freedom is exercised, understood and manifested in contemporary liberal societies. [ABSTRACT FROM AUTHOR]

The brachiopods are sessile invertebrates with an unusual blood system, which consists of a long‐branched dorsal vessel. It is still unknown how blood circulates in this system. In the present study, for the first time we propose the circulation of blood in brachiopod Hemithiris psittacea based on morphological and experimental data. The main heart is located on the dorsal side of the stomach and divides the dorsal vessel into anterior and posterior parts. The anterior part enters the lophophore, where it gives off blind branches to each tentacle. The posterior part passes by the funnels of the nephridia and forms a blindly closed network in the gonads. We suggest that the circulation of blood includes three successive stages. During the first phase of systole of the main heart, blood flows through the anterior dorsal vessel. During the second phase of systole, blood flows through the posterior dorsal vessel. During diastole, blood flows from the anterior and posterior vessels and fills the main heart. The origin of a peculiar blood system in brachiopods can be explained by reduction of the ventral vessel, which is probably correlates with the reduction of the ventral side of the brachiopod ancestor's body. Another peculiarity of brachiopod blood system is the presence of an ampullar heart, which functions as a blood depot and allows blood to move in the vessels in two directions in an oscillatory mode. The brachiopod blood system contains vessels lacking true endothelium and can be classified as an "incompletely closed" type. Research Highlights: The blood system of brachiopods contains a dorsal vessel divided into anterior and posterior parts. Circulation includes three stages: during the first phase of systole, blood flows in the anterior vessel, during the second phase of systole, blood flows in the posterior vessel, and during diastole, blood flows from the anterior and posterior vessels and fills the main heart. [ABSTRACT FROM AUTHOR]

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The Barents Sea is one of the main pathways for warm and saline Atlantic Water (AW) entering the Arctic Ocean. It is an important region where water mass transformation and dense‐water production contribute to the Atlantic meridional overturning circulation. Here, we present data from three cruises and nine glider missions conducted between 2019 and 2022 in the northwestern Barents Sea, and compare them with historical data collected between 1950 and 2009. We present circulation pathways, hydrography and volume transports of Atlantic‐ and Arctic‐origin waters. Our observations show that 0.9 ± 0.1 Sv (1 Sv = 106 m3 s−1) of Atlantic‐origin water reaches the Polar Front (PF) region before splitting into several branches and eventually subducting beneath Polar Water (PW). The amount of Atlantic‐origin water stored in the Olga Basin north of the PF is controlled by the density difference between AW and PW, and reached a maximum in the 90s when PW was particularly fresh. In the recent period from 2019 to 2022, the inflow of AW into the Barents Sea freshened by up to 0.1 g kg−1 compared to previous decades. This led to a reduction in the production of dense water, an increased temperature gradient across the PF, and a reduced poleward transport of warm water. Plain Language Summary: Warm and salty water from the Atlantic Ocean flows through the Barents Sea on its path toward the Arctic Ocean. It undergoes cooling and freshening due to interactions with the surrounding water and the atmosphere, and eventually encounters much colder and fresher Polar Water, creating a distinct boundary known as the Polar Front. We conducted several research missions in the northwestern Barents Sea between 2019 and 2022 and compared the data to historical records collected between 1950 and 2009. The cooled Atlantic Water sinks beneath the Polar Water before continuing toward the Arctic Ocean. In recent decades, the temperature of the Atlantic Water inflow has increased. The warm Atlantic Water can be traced below the Polar Front, leading to an increase in the temperature of the deeper waters north of the front. However, the amount of Atlantic Water north of the front is regulated by the density difference between the Atlantic Water and Polar Water. In the recent period of 2019–2022, the Atlantic Water reaching the front has become less salty. As a result, there is a reduced flow of warm water moving northward beneath the Polar Water and a larger temperature difference across the Polar Front. Key Points: Circulation pathways and volume transport of Atlantic‐ and Arctic‐origin waters in the northwestern Barents Sea are detailedAt the Polar Front density differences between these waters create a geostrophic current that governs warm water flow into the Arctic domainOver recent decades Atlantic Water warmed and freshened, reducing its density difference with the Polar Water and inflow across the front [ABSTRACT FROM AUTHOR]

Turbulent mixing in the ocean exerts an important control on the rate and structure of the overturning circulation. However, the balance of processes underpinning this mixing is subject to significant uncertainties, limiting our understanding of the overturning's deep upwelling limb. Here, we investigate the hitherto primarily neglected role of tens of thousands of seamounts in sustaining deep-ocean upwelling. Dynamical theory indicates that seamounts may stir and mix deep waters by generating lee waves and topographic wake vortices. At low latitudes, stirring and mixing are predicted to be enhanced by a layered vortex regime in the wakes. Using three realistic regional simulations spanning equatorial to middle latitudes, we show that layered wake vortices and elevated mixing are widespread around seamounts. We identify scalings that relate mixing rate within seamount wakes to topographic and hydrographic parameters. We then apply such scalings to a global seamount dataset and an ocean climatology to show that seamount-generated mixing makes an important contribution to the upwelling of deep waters. Our work thus brings seamounts to the fore of the deep-ocean mixing problem and urges observational, theoretical, and modeling efforts toward incorporating the seamounts' mixing effects in conceptual and numerical ocean circulation models. [ABSTRACT FROM AUTHOR]

The author reviews the history of collection development of the vinyl collection at Huntingdon College. With interviews from current and former faculty and staff, the author shows how donations of vinyl al- bums helped propel the extensive quantity of albums. The author discusses how the collection circulated throughout the 1970s to the 1990s, when CDs arrived on the scene. The quick transition to digital streaming along with short staffing has caused these vinyl albums to sit, neglected in a classroom, un- used for decades. The vinyl collection also does not have enough cataloging data for easy discoverability and circulation. The author collaborated with the main library and the music department to curate the collection, keeping rare and local items while removing the remainder. [ABSTRACT FROM AUTHOR]

The use of digital museum objects has become an essential part of museums' communication and marketing strategies, research and teaching, and curatorial practices. This new visibility, amplified by the COVID‐19 crisis, has not only revealed the possibilities of digital museum objects but has also underscored significant challenges, including the intricate relationship between digital museum objects and physical objects, the impact of digital museum objects on knowledge creation, and the online interaction with art and cultural heritage. Furthermore, it has drawn attention to the digital platforms that host digital museum objects, ranging from museum collection databases to online encyclopedias, cultural heritage platforms, and social media. The present paper explores these issues by examining how digital platforms are changing the way digital reproductions of artworks are used and reimagined, both inside and outside the institutions that house the artworks. To illuminate these dynamics, it looks at specific case studies, including the Getty Challenge, the online circulation of Delacroix's La liberté guidant le peuple, and the collection databases of Belgian museums and of the Mauritshuis. Theoretically, it combines the art historical concept of circulation with the notion of gray and colored memory drawn from digital memory studies. In doing so, it conceives of museum databases and cultural heritage platforms, as spaces of participation and neglect, of memory and oblivion, with a vast potential for producing new perspectives on art and cultural heritage and telling new (art) histories. In conclusion, the paper advocates for "circulation" as a key concept for revitalizing online collections of digital reproductions of artworks. [ABSTRACT FROM AUTHOR]

Coastal lagoons are among the most important, but also threatened, marine systems of our planet. Rainfall, wind, seawater, and freshwater discharges control water circulation in lagoons, determining the water properties that are vital for the lagoon's biodiversity. The present work is the first study on the circulation patterns and seasonal variability of hydrological parameters in Antinioti lagoon in western Greece, building a reference level on our knowledge of the hydrodynamic functioning of this marine ecosystem. This study shows that the lagoon's water properties' fluctuations and circulation variability are affected by an antagonistic effect between freshwater (river discharge, underground spring, rainfall) and seawater inputs. This effect, influenced by atmospheric forcing (rainfall, atmospheric temperature), controls the heat and salt budgets of the lagoon. Nevertheless, the lagoon keeps an almost balanced annual cycle, returning from June 2020 to June 2021 to similar values for all parameters. [ABSTRACT FROM AUTHOR]

Anthropogenic perturbations from fossil fuel burning, nuclear bomb testing, and chlorofluorocarbon (CFC) use have created useful transient tracers of ocean circulation. The atmospheric 14C/C ratio (∆14C) peaked in the early 1960s and has decreased now to pre‐industrial levels, while atmospheric CFC‐11 and CFC‐12 concentrations peaked in the early 1990s and early 2000s, respectively, and have now decreased by 10%–20%. We present the first analysis of a decade of new observations (2007 to 2018–2019) and give a comprehensive overview of the changes in ocean ∆14C and CFC concentration since the WOCE surveys in the 1990s. Surface ocean ∆14C decreased at a nearly constant rate from the 1990–2010s (20‰/decade). In most of the surface ocean ∆14C is higher than in atmospheric CO2 while in the interior ocean, only a few places are found to have increases in ∆14C, indicating that globally, oceanic bomb 14C uptake has stopped and reversed. Decreases in surface ocean CFC‐11 started between the 1990 and 2000s, and CFC‐12 between the 2000–2010s. Strong coherence in model biases of decadal changes in all tracers in the Southern Ocean suggest ventilation of Antarctic Intermediate Water was enhanced from the 1990 to the 2000s, whereas ventilation of Subantarctic Mode Water was enhanced from the 2000 to the 2010s. The decrease in surface tracers globally between the 2000 and 2010s is consistently stronger in observations than in models, indicating a reduction in vertical transport and mixing due to stratification. Plain Language Summary: The ocean contains many dissolved gases that can be measured by sampling ocean water from ships. Some of these dissolved gases are changing over time because their atmospheric concentrations are changing. By measuring these changes in the ocean, we can learn about ocean transport and mixing, which is an important factor regulating climate change. We describe ocean measurements from the past three decades of radiocarbon in dissolved inorganic carbon, that was affected by nuclear bomb testing, and of chlorofluorocarbon gases, CFCs, that were banned in the 1990s due to their destructive effects on the ozone layer. The measurements show how their oceanic distributions have changed, as a result of their atmospheric histories and the patterns of ocean uptake and transport. By comparing the measurements with ocean models, we can identify biases in the models that affect how well future climate change can be predicted. In the most recent decade, the presence of all three tracers is shown to be decreasing in the upper ocean, a reversal of the preceding decades. Also in the most recent decade, the decrease in surface tracers is stronger in the observations than the models, suggesting a change to upper ocean mixing and stratification. Key Points: Recent trends in upper ocean Δ14C, pCFC‐11, and pCFC‐12 are negative, reflecting their decreasing atmospheric trendsIncreases in ∆14C are only observed in a few places over 2000–2010s, showing oceanic bomb 14C uptake has stopped and reversedModel‐data Δ14C and chlorofluorocarbon differences could be consistent with decadal ventilation changes and large‐scale stratification or model errors [ABSTRACT FROM AUTHOR]

Background: Despite dengue virus (DENV) outbreak in Gabon a decade ago, less is known on the potential circulation of DENV serotypes in the country. Previous studies conducted in some areas of the country, are limited to hospital-based surveys which reported the presence of some cases of serotype 2 and 3 seven years ago and more recently the serotype 1. As further investigation, we extend the survey to the community of Moyen Ogooué region with the aim to assess the presence of the dengue virus serotypes, additionally to characterize chikungunya (CHIKV) infection and describe the symptomatology associated with infections. Method: A cross-sectional survey was conducted from April 2020 to March 2021. The study included participants of both sexes and any age one year and above, with fever or history of fever in the past seven days until blood collection. Eligible volunteers were clinically examined, and blood sample was collected for the detection of DENV and CHIKV using RT-qPCR. Positive samples were selected for the target sequencing. Results: A total of 579 volunteers were included. Their mean age (SD) was 20 (20) years with 55% of them being female. Four cases of DENV infection were diagnosed giving a prevalence of 0.7% (95%CI: 0.2–1.8) in our cohort while no case of CHIKV was detected. The common symptoms and signs presented by the DENV cases included fatigue, arthralgia myalgia, cough, and loss of appetite. DENV-1was the only virus detected by RT-qPCR. Conclusion: Our results confirm the presence of active dengue infection in the region, particularly DENV-1, and could suggest the decline of DENV-2 and DENV-3. Continuous surveillance remains paramount to comprehensively describe the extent of dengue serotypes distribution in the Moyen-Ogooué region of Gabon. [ABSTRACT FROM AUTHOR]

Bio-optical and physical measurements were collected in the Mississippi Sound (Northern Gulf of Mexico) during the spring of 2018 as part of the Integrated Coastal Bio-Optical Dynamics project. The goal was to examine the impact of atmospheric and tidal fronts on fine-scale physical and bio-optical property distributions in a shallow, dynamic, coastal environment. During a 25-day experiment, eight moorings were deployed in the vicinity of a frontal zone. For a one-week period in the middle of the mooring deployment, focused ship sampling was conducted with aircraft and unmanned aerial vehicle overflights, acquiring hyperspectral optical and thermal data. The personnel in the aircraft located visible color fronts indicating the convergence of two water masses and directed the ship to the front. Dye releases were performed on opposite sides of a front, and coincident aircraft and unmanned aerial vehicle overflights were collected to facilitate visualization of advection/mixing/dispersion processes. Radiometric calibration of the optical hyperspectral sensor was performed. Empirical Line Calibration was also performed to atmospherically correct the aircraft imagery using in situ remote sensing reflectance measurements as calibration sources. Bio-optical properties were subsequently derived from the atmospherically corrected aircraft and unmanned aerial vehicle imagery using the Naval Research Laboratory Automated Processing System. [ABSTRACT FROM AUTHOR]

This paper examines rituals of gift exchange in the North Indian state of Awadh in the eighteenth and early nineteenth century. It draws parallels between the gifting practices of the Nawabs and the English East India Company and examines how specific objects were selected to perform the role of gifts. It explores the practice of gift exchange where objects emerged as sites on which power was asserted, subverted and contested. In studying gifts, the aim is to delve into the institutional and ceremonial significance attributed to objects which made them the site of diplomatic encounters. The range of objects that were brought within the lexicon of gifts, and the power struggles that marked this process, inform the discussion. In exploring these themes, the paper addresses the larger question of how objects were imagined by political powers and the multiple ways in which meanings were added onto and erased from objects over the course of their circulation as gifts. [ABSTRACT FROM AUTHOR]

This study evaluates the feasibility of applying the Estimating the Circulation and Climate of the Ocean (ECCO) data assimilation (DA) framework to a submesoscale-resolving model [Massachusetts Institute of Technology General Circulation Model (MITgcm), at 1-km grid resolution]. This is in preparation for future studies to understand and assimilate the novel swath measurements of sea surface height from the Surface Water and Ocean Topography (SWOT) satellite mission. The model domain is centered at the SWOT calibration/validation (CalVal) site, located 300 km offshore of Monterey Bay, California. We assimilate vertical profiles of temperature and salinity from a linear array of three SWOT prelaunch CalVal moorings, between September and December 2019. Two model solutions are analyzed: 1) a nonassimilating forward simulation termed "first-guess" and 2) an optimized solution that assimilates the in situ observations. Both runs are nested within the global 1/12° Hybrid Coordinate Ocean Model that uses Navy Coupled Ocean Data Assimilation (HYCOM/NCODA) analysis. We evaluate the performance by comparing the two model solutions against assimilated and withheld in situ observations. We show that by assimilating hydrographic data, the model performance over the first-guess solution is improved with an error-to-observation reduction of 30%–45% for temperature, 14%–41% for salinity, and 44%–56% for steric height. Over the study period, the average steric height error at the three assimilated moorings was 1.27 cm for the optimized solution versus 2.6 cm for the first-guess solution. A comparison to withheld glider observations shows that the optimized solution outperforms the first-guess solution with an error-to-observation reduction of approximately 38% in steric height (1.5 versus 2.4 cm). This study indicates, for the first time, that the MITgcm–ECCO framework can be successfully applied to the reconstruction of submesoscale ocean variability, via the nesting of a high-resolution regional domain into a global outer domain. [ABSTRACT FROM AUTHOR]

For the last decade or more, circulation numbers of physical materials have declined in academic libraries across the United States. In the spring of 2020, the COVID-19 pandemic drastically altered society and daily life, not to mention library functions. In particular, fears of contagion via physical surfaces and transmission by contact led many libraries to shutter their in-person services or temporarily close altogether. The circulation of physical materials was hit particularly hard, as the ability to browse shelves, check out items, access interlibrary loan, and a host of other similar services were curtailed. This article will examine the statistical markers of physical material handling (checkouts, renewals, item browses, etc.) for two years before and after the pandemic, to reach conclusions about how COVID-19 impacted usage, what we can tell about general patterns in circulation before and due to these changes, and ultimately what these numbers tell us about the future of traditional material use. [ABSTRACT FROM AUTHOR]

Purpose: Exercise positively impacts social abilities like empathy, which is indispensable for sustaining relationships with others. Regular exercise at light intensity enhances empathic behavior; nonetheless, its biomarkers remain unknown. Here, we evaluated the effects of light-intensity exercise, which enhances helping behavior, on circulating miRNA profile in mice. Methods: Eight-week-old male C57BL/6 mice were subjected to exercise at light intensity (7.0 m/min, 30 min/day, 5 days/week) for four weeks and a helping behavior test. The plasma was subsequently collected to analyze miRNA expressions using next-generation sequencing. Results: We found that four weeks of light-intensity exercise significantly increased 11 miRNAs in the plasma of mice. This exercise regimen also significantly reduced 29 miRNAs in the plasma of mice. Seven out of 11 upregulated miRNAs and nine of 29 downregulated miRNAs showed significant correlations with helping behavior in mice; the miRNAs related to neuronal growth were also included, such as miR-29a-3p and miR-142b. Conclusion: These results imply that miRNAs are applicable as liquid biomarkers for reflecting the effects of light-intensity exercise on empathy; it might also be developed as a possible indicator for treating empathy. [ABSTRACT FROM AUTHOR]

Varicose veins typically occur in the lower limbs, caused by valvular insufficiency leading to the swelling and tortuosity of subcutaneous veins. Although rare in the upper limbs, they can be successfully diagnosed and treated. Rare causes include congenital vascular anomalies like Klippel-Trenaunay syndrome and Parkes Weber syndrome, characterised by Arteriovenous (AV) fistulae. Subclavian vein thrombosis-induced venous outflow obstruction is another uncommon cause. Diagnosis involves a thorough history taking with clinical examination, often supplemented by investigations. Invasive procedures are rarely necessary but may be used in unique cases to define the pathology further. Treatment for upper limb varicose veins closely mirrors lower limb approaches. The stab-avulsion technique combined with stripping of lengthier sections yields outstanding cosmetic and functional results. Surgical ligation with stripping effectively eliminates varicosities with a low risk of recurrence. Sclerosing agents like Sodium Tetradecyl Sulphate and Polidocanol are substitutes for surgery. In cases of varicosities resulting from upper limb arteriovenous fistulae, surgical intervention involving ligation of the distal venous limb or division of the fistula is the standard approach. In summary, while upper limb varicose veins are exceptionally rare, they can be accurately diagnosed and effectively treated with surgical interventions similar to lower limb varicose veins. [ABSTRACT FROM AUTHOR]

The aircraft wake vortex is an important factor affecting flight safety; as an important part of the aircraft, the powered nacelle will inevitably have an important impact on the aircraft wake vortex, so it is of great practical significance to research it. The present study focused on the numerical simulation of the wake flow of large aircraft (as the front aircraft) and the comparative analysis of the influence of engine jets on the wake flow. In order to meet the accuracy requirements and control the consumption of computing resources, LES and RANS methods were compared, and the RANS method was finally selected for subsequent calculation. The dynamic effect of jet flow was simulated by simplifying the boundary conditions of the inlet fan and outlet bypass as the mass flow boundary condition. The simulation results showed that the engine nacelle will have a significant impact on the morphology of the aircraft wake flow (position and strength of the main vortex in the wake flow system), which is caused by the vortices formed under the shear flow and separated flow of the nacelle. However, the nacelle will not significantly change the total strength of the wake vortex (half-plane circulation). The engine jet intensity causes additional turbulent mixing, which will accelerate the fusion of the nacelle vortex and ultimately change the intensity ratio of the inner wing vortex and the wingtip vortex, affecting the trajectory of the wake of the mean vortex. The study provides a corresponding reference for the following research on a wake vortex by a powered nacelle. [ABSTRACT FROM AUTHOR]

We provide observational evidence that the stability of the stratospheric Polar vortex (PV) is a significant driver of sub‐seasonal variability in the thermosphere during geomagnetically quiet times when the PV is anomalously strong or weak. We find strong positive correlations between the Northern Annular Mode (NAM) index and subseasonal (10–90 days) Global Observations of the Limb and Disk (GOLD) O/N2 perturbations at low to mid‐northern latitudes, with a largest value of +0.55 at ∼30.0°N when anomalously strong or weak (NAM >2.5 or < −2.1) vortex times are considered. Strong agreement for O/N2 variability and O/N2‐NAM correlations is found between GOLD observations and the Whole Atmosphere Community Climate Model with thermosphere‐ionosphere eXtension (WACCM‐X) simulations, which is then used to delineate the global distribution of O/N2‐NAM correlations. We find negative correlations between subseasonal variability in WACCM‐X O/N2 and NAM at high northern and southern latitudes (as large as −0.54 at ∼60.0°S during anomalous vortex times). These correlations suggest that PV driven upwelling at low latitudes is accompanied by corresponding downwelling at high latitudes in the lower thermosphere (∼80–120 km), which is confirmed using calculations of residual mean meridional circulation from WACCM‐X. Plain Language Summary: The stratospheric Polar vortex (PV) is a large‐scale circulation pattern that forms over the poles during the winter months, characterized by strong winds circulating in a counterclockwise direction in the Northern Hemisphere. It has previously been demonstrated that the breakup of the PV during sudden stratospheric warming (SSW) events has a large effect on the composition of the thermosphere. We demonstrate that the PV also influences thermospheric composition during non‐SSW times, including time periods in which the vortex is strong and times in which the vortex is inactive, by correlating observations of thermospheric O/N2 from the Global Observations of the Limb and Disk (GOLD) instrument with the Northern Annular Mode (NAM) index, which tracks the strength of the PV. We also find strong anti‐correlations between O/N2 and tidal amplitudes from model simulations, which suggests that the PV influences thermospheric composition via changes in mean circulation induced by the dissipation of enhanced waves. We use model simulations to confirm that the NAM‐O/N2 correlations reflect PV induced changes in global circulation patterns. We find that the PV causes enhanced upwelling at low latitudes and corresponding downwelling at high latitudes in both the northern and southern hemispheres. Key Points: Polar vortex (PV) activity is correlated with sub‐seasonal O/N2 variability during low Kp winter times at all latitudesWe observe enhanced O/N2 at high southern latitudes and reduced O/N2 at low latitudes in response to northern hemisphere PV activityPV‐O/N2 correlations are shown to reflect PV induced modulations of the residual mean meridional circulation (MMC) [ABSTRACT FROM AUTHOR]

Hepatitis C is regarded as a global health issue caused by hepatitis C virus (HCV) infection. HCV is targeted for elimination by 2030 as a global public health goal. However, the COVID-19 pandemic has changed human circulation and prevented access to diagnostics and treatment to many other diseases, including hepatitis C. COVID-19 impacted HCV global elimination efforts with implications not fully comprehended yet. The high genetic variability in HCV makes the development of vaccines and pan-genotypic drug therapies a difficult task. Changes in the dynamics of HCV impose new challenges for public health and opportunities for future research. Meta-analysis, the follow up of new cases and sampling of HCV patients compared with previously available data are options for investigating the possible changes. The determination of HCV genotypes and subtypes is important for understanding viral dynamics and treatment; therefore, the changes in genotype and subtype prevalences can directly affect such processes. Recent results in the literature already suggest changes in HCV dynamics during the COVID-19 pandemic, both considering viral circulation and differential genotypic frequencies in distinct geographic areas. In this context, we propose a further examination of these trends using different approaches to provide support for the hypothesis that the COVID-19 pandemic affected HCV circulation, since these findings would have important implications for hepatitis C prevention, treatment and research. [ABSTRACT FROM AUTHOR]

Abstract The southern tropical Indian Ocean (TIO) displays large mixed layer salinity (MLS) variation. Circulation in this region is governed by the Indian Ocean tropical gyre (IOTG), where the source water proportion and associated mixing remain unclear. Particles integrating into the IOTG and entering the central southern TIO originate from the Bay of Bengal, Malacca Strait, western Indian Ocean, and Indonesian Throughflow. Surprisingly, cross‐equatorial advection is particularly important, implying a significant connection between both the Bay of Bengal and the South China Sea via Malacca Strait into the southern TIO. The anomalous anticlockwise circulation weakens the IOTG during positive Indian Ocean Dipole (IOD). An opposite pattern is observed in the negative IOD. A particle experiment reveals that water masses are modulated by the anomalous circulation that drives the redistribution of MLS by changing the proportion of the different source waters. This represents a potential predictability for the southern TIO MLS variability.

ABSTRACT: The clinical relevance of avian metapneumovirus (aMPV) is growing in the poultry sector, especially in broiler farming, where no vaccination is administered in Italy. Given the naïve status of the birds, a serological survey was conducted in a densely populated area of Northern Italy, to evaluate aMPV circulation. Seven farms were selected and sampled in summer/fall, then sampling was repeated in the following season (winter/spring) to assess a possible seasonal effect. In each farm, fifteen birds were blood sampled towards the end of the cycle and sera were analyzed with an ELISA test. Clinical signs were reported in 5 out of 7 farms, although all farms were positive at both sampling points, except for one, which was negative at the first sampling. The seroprevalence within farm ranged from 26.6% to 100%, and antibody titres appear to increase with age. No seasonality effect was evidenced, whereas a farm effect was more distinct. aMPV circulation appears wide in Northern Italian farms, with different clinical outcomes that could be modulated by intrinsic characteristics of the farms. In absence of vaccination, serological monitoring can be a useful tool for viral entrance monitoring, although sampling timing should be evaluated in order to spot seroconversion after late infections.