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2. Clonal KEAP1 mutations with loss of heterozygosity share reduced immunotherapy efficacy and low immune cell infiltration in lung adenocarcinoma

Author

Scalera, S., primary, Ricciuti, B., additional, Mazzotta, M., additional, Calonaci, N., additional, Alessi, J.V., additional, Cipriani, L., additional, Bon, G., additional, Messina, B., additional, Lamberti, G., additional, Di Federico, A., additional, Pecci, F., additional, Milite, S., additional, Krasniqi, E., additional, Barba, M., additional, Vici, P., additional, Vecchione, A., additional, De Nicola, F., additional, Ciuffreda, L., additional, Goeman, F., additional, Fanciulli, M., additional, Buglioni, S., additional, Pescarmona, E., additional, Sharma, B., additional, Felt, K.D., additional, Lindsay, J., additional, Rodig, S.J., additional, De Maria, R., additional, Caravagna, G., additional, Cappuzzo, F., additional, Ciliberto, G., additional, Awad, M.M., additional, and Maugeri-Saccà, M., additional

Published
2023
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3. Climate Change and Fish Farming: Venetian “Fish Valleys” as a Design Device for Coastal Adaptation and Mitigation

Author

Cipriani, L. (author), Destro, Alessandro (author), Cipriani, L. (author), and Destro, Alessandro (author)

Abstract

Beginning in the fourteenth century, along the northeastern Italian coastline, Venetians began to create a series of hydraulic structures called “fishing valleys,” which combined aquaculture production with lagoon and seawater management. According to the current scenarios provided by the Intergovernmental Panel on Climate Change, the coastal areas, where many historic fish farms still stand, will inevitably be affected by the rise in sea level. To be preserved, coastlines will require some sort of water defense or possibly a managed retreat. Can we redesign traditional fish-farm systems as climate, economic and environmental adaptation devices? Through a series of design scenarios, this contribution explores how traditional fish farming can help redefine the territorial scale by addressing climate change and reviving existing production systems., Landscape Architecture

Published
2023

4. Statements on Landscape Architecture Programs Worldwide: Case Studies across the Globe

Author

Cipriani, L. (author), Villalobos, Maria (author), Cipriani, L. (author), and Villalobos, Maria (author)

Abstract

This article drafts a global picture of landscape program offerings worldwide through data collection, mapping, and targeted interviews. The study presents data collection on landscape architecture programs throughout the world and interviews with graduate program directors. The selection criteria for the case studies address diversity in crucial categories. The interviews elucidate current curricular trends in master’s degree tracks. This research supports the view that global landscape programs are mainly a product of Western knowledge, dealing with urban centers primarily located in one of the world’s 14 biomes. At the master’s level, programs respond to diverse missions according to context, cultural differences, and traditions. Future trends and challenges for landscape architecture programs include climate change, new technologies, social justice, and equity. In light of these findings, we call for a collective landscape education to respond to unprecedented and overwhelming climatic, economic, and social uncertainties., Landscape Architecture

Published
2023
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5. The geology of landscapes: Times, rhythms, palimpsests of the Rhenish crater

Author

Cipriani, L. (author) and Cipriani, L. (author)

Abstract

The Hambach mine is one of Europe’s largest and deepest open-cast coal mines. Humans have transformed the landscape to the point of giving life to a new geological era. The mine is the symbol of humanity’s power over territorial, environmental, and climatic transformations at impressive levels of scale and scope. This contribution sums up five different times of the Hambach mine landscape, with its rhythms and palimpsests: deep geological time, historical time, the rapid anthropogenic time of excavation, the present time of transition towards new forms of energy, and finally, future time with the conversion of the crater into a lake. Time is the driving force of this place in light of the geological, anthropic, and climatic changes. The work presents a reflection on the IDEA League summer workshop held in 2022 by TU Delft in collaboration with Aachen University and Politecnico di Milano., Landscape Architecture

Published
2023
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6. The past, present and future of the Wadden Sea, its islands and hinterland

Author

Cipriani, L. (author) and Cipriani, L. (author)

Abstract

Lagoons, wetlands, islands, and their inland areas struggle between two opposing forces, permanence, and transformation. Coastal lagoons are constantly evolving dynamic natural ecosystems, shaped over the centuries by natural phenomena and ongoing anthropic interventions. The war between man and nature is waged on various fronts: geo-morphological, climatic, ecological-environmental, architectural, and landscape, as well as in urban settlements. Despite being a UNESCO World Heritage Site of extraordinary environmental value and beauty, the Wadden Sea, its territories, and its people, are facing an uncertain future, while currently wrestling with a latent climatic, economic-productive, and social crisis. Subsidence increased by gas extraction, soil erosion, saltwater intrusion, eutrophication, and agricultural water pollution testify to a territory in the throes of long-term repossession by the sea. Unlike large coastal conurbations, these areas are marginal territories, with low levels of urbanization, and are mainly linked to agricultural, fishing, tourist development, and dying industrial activities. Starting from the past, the present, and its legacies, the presented work will present many possible futures of the Wadden Sea and its hinterland., Landscape Architecture

Published
2023

7. REL22 Reinventing Energy Landscapes

Author

Cipriani, L. (author), Beretta, Silvia (author), Longo, Antonio (author), Geroldi, Chiara (author), Wirth, Matti (author), Cipriani, L. (author), Beretta, Silvia (author), Longo, Antonio (author), Geroldi, Chiara (author), and Wirth, Matti (author)

Abstract

REL22 was an international summer school program launched by the Institute of Landscape Architecture of RWTH Aachen University (Prof. Frank Lohrberg, Silvia Beretta) together with the Master’s Programme in „Landscape Architecture and Landscape Heritage“ of Politecnico di Milano (Prof. Antonio Longo) and the Master’s Programme in “Landscape Architecture” of TU Delft (Prof. Laura Cipriani). The aim was to formulate visions for the landscape transformation of the Rhenish Lignite District, the largest open-cast lignite mining area in Europe, located in the German region of North Rhine Westphalia., Landscape Architecture

Published
2023
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8. REL22 Reinventing Energy Landscapes

Author

Cipriani, L., Beretta, Silvia, Longo, Antonio, Geroldi, Chiara, and Wirth, Matti

Subjects
Energy landscapes, Mine reclamation, Landscape reclamation, water and soil, Hambach mine, Rhenish Lignite District
Abstract

REL22 was an international summer school program launched by the Institute of Landscape Architecture of RWTH Aachen University (Prof. Frank Lohrberg, Silvia Beretta) together with the Master’s Programme in „Landscape Architecture and Landscape Heritage“ of Politecnico di Milano (Prof. Antonio Longo) andthe Master’s Programme in “Landscape Architecture” of TU Delft (Prof. Laura Cipriani). The aim was to formulate visions for the landscape transformation of the Rhenish Lignite District, the largest open-cast lignite mining area in Europe, located in the German region of North Rhine Westphalia.

Published
2023

9. The Geology of Landscapes: Times, rhythms, palimpsests of the Rhenish crater

Author

Cipriani, L., Beretta, Silvia, Cipriani, Laura, Longo, Antonio, Geroldi, Chiara, and Wirth, Matti

Subjects
water and soil, reclamation, Hambach mine, landscape geology, palimpsests
Abstract

The Rhenish crater is one of Europe’s largest and deepest open-cast coal mines. Humans have transformed the landscape to the point of giving life to a new geological era. The mine is the symbol of humanity’s power over territorial, environmental, and climatic transformations at impressive levels of scale and scope.This contribution sums up five different times of the Hambach mine landscape, with its rhythms and palimpsests: deep geological time, historical time, the rapid anthropogenic time of excavation, the present time of transition towards new forms of energy, and finally, future time with the conversion of the crater into a lake.

Published
2023

10. More nature in the city

Author

Capotorti, G, Bonacquisti, S, Abis, L, Aloisi, I, Attorre, F, Bacaro, G, Balletto, G, Banfi, E, Barni, E, Bartoli, F, Bazzato, E, Beccaccioli, M, Braglia, R, Bretzel, F, Brighetti, M, Brundu, G, Burnelli, M, Calfapietra, C, Cambria, V, Caneva, G, Canini, A, Caronni, S, Castello, M, Catalano, C, Celesti-Grapow, L, Cicinelli, E, Cipriani, L, Citterio, S, Concu, G, Coppi, A, Corona, E, Del Duca, S, Del, V, Di Gristina, E, Domina, G, Faino, L, Fano, E, Fares, S, Farris, E, Farris, S, Fornaciari, M, Gaglio, M, Galasso, G, Galletti, M, Gargano, M, Gentili, R, Giannotta, A, Guarino, C, Guarino, R, Iaquinta, G, Iiriti, G, Lallai, A, Lallai, E, Lattanzi, E, Manca, S, Manes, F, Marignani, M, Marinangeli, F, Mariotti, M, Mascia, F, Mazzola, P, Meloni, G, Michelozzi, P, Miraglia, A, Montagnani, C, Mundula, L, Muresan, A, Musanti, F, Nardini, A, Nicosia, E, Oddi, L, Orlandi, F, Pace, R, Palumbo, M, Palumbo, S, Parrotta, L, Pasta, S, Perini, K, Poldini, L, Postiglione, A, Prigioniero, A, Proietti, C, Raimondo, F, Ranfa, A, Redi, E, Reverberi, M, Roccotiello, E, Ruga, L, Savo, V, Scarano, P, Schirru, F, Sciarrillo, R, Scuderi, F, Sebastiani, A, Siniscalco, C, Sordo, A, Suanno, C, Tartaglia, M, Tilia, A, Toffolo, C, Toselli, E, Travaglini, A, Ventura, F, Venturella, G, Vincenzi, F, Blasi, C, Capotorti G., Bonacquisti S., Abis L., Aloisi I., Attorre F., Bacaro G., Balletto G., Banfi E., Barni E., Bartoli F., Bazzato E., Beccaccioli M., Braglia R., Bretzel F., Brighetti M. A., Brundu G., Burnelli M., Calfapietra C., Cambria V. E., Caneva G., Canini A., Caronni S., Castello M., Catalano C., Celesti-Grapow L., Cicinelli E., Cipriani L., Citterio S., Concu G., Coppi A., Corona E., Del Duca S., Del V. E., Di Gristina E., Domina G., Faino L., Fano E. A., Fares S., Farris E., Farris S., Fornaciari M., Gaglio M., Galasso G., Galletti M., Gargano M. L., Gentili R., Giannotta A. P., Guarino C., Guarino R., Iaquinta G., Iiriti G., Lallai A., Lallai E., Lattanzi E., Manca S., Manes F., Marignani M., Marinangeli F., Mariotti M., Mascia F., Mazzola P., Meloni G., Michelozzi P., Miraglia A., Montagnani C., Mundula L., Muresan A. N., Musanti F., Nardini A., Nicosia E., Oddi L., Orlandi F., Pace R., Palumbo M. E., Palumbo S., Parrotta L., Pasta S., Perini K., Poldini L., Postiglione A., Prigioniero A., Proietti C., Raimondo F. M., Ranfa A., Redi E. L., Reverberi M., Roccotiello E., Ruga L., Savo V., Scarano P., Schirru F., Sciarrillo R., Scuderi F., Sebastiani A., Siniscalco C., Sordo A., Suanno C., Tartaglia M., Tilia A., Toffolo C., Toselli E., Travaglini A., Ventura F., Venturella G., Vincenzi F., Blasi C., Capotorti, G, Bonacquisti, S, Abis, L, Aloisi, I, Attorre, F, Bacaro, G, Balletto, G, Banfi, E, Barni, E, Bartoli, F, Bazzato, E, Beccaccioli, M, Braglia, R, Bretzel, F, Brighetti, M, Brundu, G, Burnelli, M, Calfapietra, C, Cambria, V, Caneva, G, Canini, A, Caronni, S, Castello, M, Catalano, C, Celesti-Grapow, L, Cicinelli, E, Cipriani, L, Citterio, S, Concu, G, Coppi, A, Corona, E, Del Duca, S, Del, V, Di Gristina, E, Domina, G, Faino, L, Fano, E, Fares, S, Farris, E, Farris, S, Fornaciari, M, Gaglio, M, Galasso, G, Galletti, M, Gargano, M, Gentili, R, Giannotta, A, Guarino, C, Guarino, R, Iaquinta, G, Iiriti, G, Lallai, A, Lallai, E, Lattanzi, E, Manca, S, Manes, F, Marignani, M, Marinangeli, F, Mariotti, M, Mascia, F, Mazzola, P, Meloni, G, Michelozzi, P, Miraglia, A, Montagnani, C, Mundula, L, Muresan, A, Musanti, F, Nardini, A, Nicosia, E, Oddi, L, Orlandi, F, Pace, R, Palumbo, M, Palumbo, S, Parrotta, L, Pasta, S, Perini, K, Poldini, L, Postiglione, A, Prigioniero, A, Proietti, C, Raimondo, F, Ranfa, A, Redi, E, Reverberi, M, Roccotiello, E, Ruga, L, Savo, V, Scarano, P, Schirru, F, Sciarrillo, R, Scuderi, F, Sebastiani, A, Siniscalco, C, Sordo, A, Suanno, C, Tartaglia, M, Tilia, A, Toffolo, C, Toselli, E, Travaglini, A, Ventura, F, Venturella, G, Vincenzi, F, Blasi, C, Capotorti G., Bonacquisti S., Abis L., Aloisi I., Attorre F., Bacaro G., Balletto G., Banfi E., Barni E., Bartoli F., Bazzato E., Beccaccioli M., Braglia R., Bretzel F., Brighetti M. A., Brundu G., Burnelli M., Calfapietra C., Cambria V. E., Caneva G., Canini A., Caronni S., Castello M., Catalano C., Celesti-Grapow L., Cicinelli E., Cipriani L., Citterio S., Concu G., Coppi A., Corona E., Del Duca S., Del V. E., Di Gristina E., Domina G., Faino L., Fano E. A., Fares S., Farris E., Farris S., Fornaciari M., Gaglio M., Galasso G., Galletti M., Gargano M. L., Gentili R., Giannotta A. P., Guarino C., Guarino R., Iaquinta G., Iiriti G., Lallai A., Lallai E., Lattanzi E., Manca S., Manes F., Marignani M., Marinangeli F., Mariotti M., Mascia F., Mazzola P., Meloni G., Michelozzi P., Miraglia A., Montagnani C., Mundula L., Muresan A. N., Musanti F., Nardini A., Nicosia E., Oddi L., Orlandi F., Pace R., Palumbo M. E., Palumbo S., Parrotta L., Pasta S., Perini K., Poldini L., Postiglione A., Prigioniero A., Proietti C., Raimondo F. M., Ranfa A., Redi E. L., Reverberi M., Roccotiello E., Ruga L., Savo V., Scarano P., Schirru F., Sciarrillo R., Scuderi F., Sebastiani A., Siniscalco C., Sordo A., Suanno C., Tartaglia M., Tilia A., Toffolo C., Toselli E., Travaglini A., Ventura F., Venturella G., Vincenzi F., and Blasi C.

Abstract

According to projects and practices that the Italian botanists and ecologists are carrying out for bringing “more nature in the city”, new insights for a factual integration between ecological perspectives and more consolidated aesthetic and agronomic approaches to the sustainable planning and management of urban green areas are provided.

Published
2020

11. Land of sand: reclaiming the sea, landscapes and lives in Malacca, Malaysia

Author

Cipriani, L. (author) and Cipriani, L. (author)

Abstract

Today, the landscapes of Asia—and Southeast Asia in particular—are undergoing major transformations, many of which are due to urbanisation processes that impact coastal areas. These are often controversial reclamation projects, generically referred to as the ‘war of sand’—an (in)visible conflict named for the raw material used to develop artificial land for property development. In Malacca, Malaysia, coastal urbanisation engenders serious environmental damage via the elimination of mangroves, deterioration of water quality and marine ecosystems, and erosion. It also causes severe social and economic transformation that leads to specific social dynamics marked by the marginalisation of certain ethnic minorities. This invites us to rethink the right to the city and the landscape in the moment of reclaiming land. For this purpose, this article describes how coastal development and reclamation projects are heavily mining local communities and the environment. The sand war, it turns out, is not purely a resource-grabbing conflict nor a real estate process with heavy environmental implications, but an implicit war against ethnic and religious communities. Inequality is a consequence not by accident but by design., Landscape Architecture

Published
2022
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13. Determinants of SARS-CoV-2 infection in Italian healthcare workers: a multicenter study

Author

Boffetta P., Violante F., Durando P., De Palma G., Pira E., Vimercati L., Cristaudo A., Icardi G., Sala E., Coggiola M., Tafuri S., Gattini V., Apostoli P., Spatari G., De Maria L., Caputi A., Sponselli S., Mastrippolito C., Zunarelli C., Di Felice G., Visci G., Albini E., Sansone E., Tomasi C., Bisioli A., Cipriani L., De Bellis A., Tiraboschi M. M., Paraggio E., Rubino S., Capuzzi M., Dini G., Bruzzone B., Debarbieri N., Montecucco A., Orsi A., Rahmani A., Ricucci V., Guglielmi G., Fiorentino L., Brilli C., Godono A., Declementi M., Mansour I., Milanesio N., Garzaro G., Scarmozzino A., Gullino A., Boffetta P., Violante F., Durando P., De Palma G., Pira E., Vimercati L., Cristaudo A., Icardi G., Sala E., Coggiola M., Tafuri S., Gattini V., Apostoli P., Spatari G., De Maria L., Caputi A., Sponselli S., Mastrippolito C., Zunarelli C., Di Felice G., Visci G., Albini E., Sansone E., Tomasi C., Bisioli A., Cipriani L., De Bellis A., Tiraboschi M.M., Paraggio E., Rubino S., Capuzzi M., Dini G., Bruzzone B., Debarbieri N., Montecucco A., Orsi A., Rahmani A., Ricucci V., Guglielmi G., Fiorentino L., Brilli C., Godono A., Declementi M., Mansour I., Milanesio N., Garzaro G., Scarmozzino A., and Gullino A.

Subjects
Adult, Male, medicine.medical_specialty, Science, Health Personnel, 030501 epidemiology, Logistic regression, Lower risk, Article, Malaise, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, COVID-19, Female, Humans, Italy, Mass Screening, Middle Aged, Occupational Diseases, SARS-CoV-2, Epidemiology, Medicine, 030212 general & internal medicine, Risk factor, Personal protective equipment, Mass screening, Multidisciplinary, business.industry, Risk of infection, Odds ratio, Confidence interval, Occupational Disease, Risk factors, Emergency medicine, medicine.symptom, 0305 other medical science, business, Health occupations, Human
Abstract

BackgroundHealthcare workers (HCW) are at increased risk of being infected with SARS-CoV-2, yet limited information is available on risk factors of infection.MethodsWe pooled data on occupational surveillance of 10,654 HCW who were tested for SARS-CoV-2 infection in six Italian centers. Information was available on demographics, job title, department of employment, source of exposure, use of personal protective equipment (PPE), and COVID-19-related symptoms. We fitted multivariable logistic regression models to calculate odds ratios (OR) and 95% confidence intervals (CI).FindingsThe prevalence of infection varied across centers and ranged from 3.0% to 22.0%, being strongly correlated with that of the respective areas. Women were at lower risk of infection compared to men. Fever, cough, dyspnea and malaise were the symptoms most strongly associated with infection, together with anosmia and ageusia. No differences in the risk of infection were detected between job titles, or working in a COVID-19 designated department. Reported contact with a patient inside or outside the workplace was a risk factor. Use of a mask was strongly protective against risk of infection as was use of gloves. The use of a mask by the source of exposure (patient or colleague) had an independent effect in reducing infection risk.

Published
2021

14. Limitaciones en el levantamiento digital de bienes patrimoniales con tipología de torre = Limitations in the digital survey of heritage assets with tower typology

Author

Sanchez S. M., Vidal F. J., Cipriani L., Rios J. L. D., Sanchez S.M., Vidal F.J., Cipriani L., and Rios J.L.D.

Subjects
Laser scanner, Photogrammetry, Bell tower, Limitation
Abstract

Digital terrestrial survey techniques such as photogrammetry (SfM) and 3D laser scanning have certain limitations. These depend on the tools used, geometry, lighting conditions and distance from the element which is being surveyed. Therefore, the aim of this study is to describe a method for the correct digital survey of high elements (with tower typology) when working with such restrictions, as well as to verify the relevance of its usefulness. This methodology is applied to two bell towers located in Ravenna (Italy) allowing a series of tests and reasoning on geometric accuracy and quality of the texture obtained in final models. Las técnicas de levantamiento digital terrestres como la fotogrametría (SfM) y el láser escáner 3D (TLS) poseen ciertas limitaciones en función de las herramientas utilizadas y de la geometría, condiciones de iluminación y distancia del elemento con el que se trabaja. Por ello, el objetivo de este estudio es describir un método para el correcto levantamiento digital de elementos altos (con tipología de torre) cuando se trabaja con dichas restricciones, así como verificar la pertinencia de su utilidad. Dicha metodología se aplica a dos torres campanario situadas en Ravenna (Italia) permitiendo realizar una serie de ensayos y razonamientos sobre la precisión y la calidad de la textura obtenida en los modelos finales.

Published
2021

15. Ceftolozane/Tazobactam for Treatment of Severe ESBL-Producing

Author

Bassetti, M., Vena, A., Giacobbe, D. R., Falcone, M., Tiseo, G., Giannella, M., Pascale, R., Meschiari, M., Digaetano, M., Oliva, A., Rovelli, C., Carannante, N., Losito, A. R., Carbonara, S., Mariani, M. F., Mastroianni, A., Angarano, G., Tumbarello, M., Tascini, C., Grossi, P., Mastroianni, C. M., Mussini, C., Viale, P., Menichetti, F., Viscoli, C., Russo, A., Verdenelli, S., Fabiani, S., Castaldo, N., Pecori, D., Carnellutti, A., Givone, F., Graziano, E., Merelli, M., Cadeo, B., Peghin, M., Cattelan, A., Cipriani, L., Coletto, D., Gianluca, R., Ciardi, M. R., Ajassa, C., Tieghi, T., Pontino, P., Raffaelli, F., Artioli, S., Caruana, G., Luzzati, R., Bontempo, G., Petrosillo, N., Capone, A., Rizzardini, G., Coen, M., Passerini, M., Guadagnino, G., Urso, F., Borgia, G., Gentile, I., Maraolo, A. E., Crapis, M., Venturini, S., Parruti, G., Trave, F., Girardis, M., Cascio, A., Gioe, C., Anselmo, M., Malfatto, E., Bassetti, Matteo, Vena, Antonio, Giacobbe, Daniele Roberto, Falcone, Marco, Tiseo, Giusy, Giannella, Maddalena, Pascale, Renato, Meschiari, Marianna, Digaetano, Margherita, Oliva, Alessandra, Rovelli, Cristina, Carannante, Novella, Losito, Angela Raffaella, Carbonara, Sergio, Mariani, Michele Fabiano, Mastroianni, Antonio, Angarano, Gioacchino, Tumbarello, Mario, Tascini, Carlo, Grossi, Paolo, Mastroianni, Claudio Maria, Mussini, Cristina, Viale, Pierluigi, Menichetti, Francesco, Viscoli, Claudio, Russo, Alessandro, Bassetti M., Vena A., Giacobbe D.R., Falcone M., Tiseo G., Giannella M., Pascale R., Meschiari M., Digaetano M., Oliva A., Rovelli C., Carannante N., Losito A.R., Carbonara S., Mariani M.F., Mastroianni A., Angarano G., Tumbarello M., Tascini C., Grossi P., Mastroianni C.M., Mussini C., Viale P., Menichetti F., Viscoli C., Russo A., Verdenelli S., Fabiani S., Castaldo N., Pecori D., Carnellutti A., Givone F., Graziano E., Merelli M., Cadeo B., Peghin M., Cattelan A., Cipriani L., Coletto D., Gianluca R., Ciardi M.R., Ajassa C., Tieghi T., Pontino P., Raffaelli F., Artioli S., Caruana G., Luzzati R., Bontempo G., Petrosillo N., Capone A., Rizzardini G., Coen M., Passerini M., Guadagnino G., Urso F., Borgia G., Gentile I., Maraolo A.E., Crapis M., Venturini S., Parruti G., Trave F., Girardis M., Cascio A., Gioe C., Anselmo M., Malfatto E., Russo, Alessandro &amp, and Luzzati, R.

Subjects
medicine.medical_specialty, ceftolozane/tazobactam, medicine.medical_treatment, CRRT, Tazobactam, Enterobacterales, Enterobacterale, Internal medicine, ESBL, septic shock, Major Article, medicine, Clinical endpoint, Renal replacement therapy, business.industry, Septic shock, Retrospective cohort study, Odds ratio, medicine.disease, Ceftolozane/tazobactam, AcademicSubjects/MED00290, Infectious Diseases, Oncology, Ceftolozane, business, Empiric therapy, medicine.drug
Abstract

Background Few data are reported in the literature about the outcome of patients with severe extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections treated with ceftolozane/tazobactam (C/T), in empiric or definitive therapy. Methods A multicenter retrospective study was performed in Italy (June 2016–June 2019). Successful clinical outcome was defined as complete resolution of clinical signs/symptoms related to ESBL-E infection and lack of microbiological evidence of infection. The primary end point was to identify predictors of clinical failure of C/T therapy. Results C/T treatment was documented in 153 patients: pneumonia was the most common diagnosis (n = 46, 30%), followed by 34 cases of complicated urinary tract infections (22.2%). Septic shock was observed in 42 (27.5%) patients. C/T was used as empiric therapy in 46 (30%) patients and as monotherapy in 127 (83%) patients. Favorable clinical outcome was observed in 128 (83.7%) patients; 25 patients were considered to have failed C/T therapy. Overall, 30-day mortality was reported for 15 (9.8%) patients. At multivariate analysis, Charlson comorbidity index >4 (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.9–3.5; P = .02), septic shock (OR, 6.2; 95% CI, 3.8–7.9; P < .001), and continuous renal replacement therapy (OR, 3.1; 95% CI, 1.9–5.3; P = .001) were independently associated with clinical failure, whereas empiric therapy displaying in vitro activity (OR, 0.12; 95% CI, 0.01–0.34; P < .001) and adequate source control of infection (OR, 0.42; 95% CI, 0.14–0.55; P < .001) were associated with clinical success. Conclusions Data show that C/T could be a valid option in empiric and/or targeted therapy in patients with severe infections caused by ESBL-producing Enterobacterales. Clinicians should be aware of the risk of clinical failure with standard-dose C/T therapy in septic patients receiving CRRT.

Published
2020

21. The Death and Life of a Tropical Landscape: Envisaging a New Melaka, Malaysia

Author

Cipriani, L., Azzali, Simona, and Thirumaran, K.

Subjects
Resource (biology), Reclamation projects, biology, Melaka city, Context (language use), Livelihood, Dredging, Design scenarios, Geography, Landscape economies, Land reclamation, Work (electrical), Deforestation, Toll, Tropical landscape, biology.protein, Environmental planning
Abstract

The UNESCO heritage city of Melaka, Malaysia, is a historically rich centre, but one in which environmental, urban, and above all social crises are currently taking a heavy toll: building speculation, strong touristic spatial imbalances, reclamation work along the coast with immense dredging operations, deforestation of coastal mangroves, soil erosion, sea-water incursion, water pollution, and hydraulic risk are the heavy price paid for the city’s rapid and destructive development. In addition, it is also evident that behind the changes in the built landscape lies racial and religious discrimination against certain ethnic minorities. In this context a small fishing community, descants of the early Portuguese colonizers, merits special mention as pharaonic reclamation projects, and dredging work are destroying the marine ecosystem upon which the already severely compromised livelihood of these fishermen depends. This article aims to present a series of design scenarios to tackle complex issues at city scale. Design works start from the belief that the landscape is not only an environmental resource, but also a factor that can become an economic resource, a major driving force for alternative development of the territory and its cities and people.

Published
2021

24. The Death and Life of a Tropical Landscape: Envisaging a New Melaka, Malaysia

Author

Cipriani, L. (author) and Cipriani, L. (author)

Abstract

The UNESCO heritage city of Melaka, Malaysia, is a historically rich centre, but one in which environmental, urban, and above all social crises are currently taking a heavy toll: building speculation, strong touristic spatial imbalances, reclamation work along the coast with immense dredging operations, deforestation of coastal mangroves, soil erosion, sea-water incursion, water pollution, and hydraulic risk are the heavy price paid for the city’s rapid and destructive development. In addition, it is also evident that behind the changes in the built landscape lies racial and religious discrimination against certain ethnic minorities. In this context a small fishing community, descants of the early Portuguese colonizers, merits special mention as pharaonic reclamation projects, and dredging work are destroying the marine ecosystem upon which the already severely compromised livelihood of these fishermen depends. This article aims to present a series of design scenarios to tackle complex issues at city scale. Design works start from the belief that the landscape is not only an environmental resource, but also a factor that can become an economic resource, a major driving force for alternative development of the territory and its cities and people., Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., Landscape Architecture

Published
2021
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25. An EU Common Training Framework for Landscape Architecture addressing the current needs of society

Author

Cipriani, L. (author), de Vries, Jeroen (author), Stauskis, Gintaras (author), Auweck, Fritz (author), Triboi, Roxana (author), Andreucci, Maria Beatrice (author), Cervera Alonso de Medina, Marina (author), Cancela d’ Abreu, Margarida (author), Freire, Maria (author), Carapinha, Aurora (author), a Conceição Castro, Maria (author), Del Pozo, Cristina (author), Deveikienė, Vaiva (author), Gunnlaugsson, Hermann Georg (author), Fekete, Albert (author), Fetzer, Ellen (author), Fabris, Luca (author), Fingerova, Radmila (author), Gazvoda, Davorin (author), Gkoltsiou, Aikaterini (author), Harmanescu, Mihaela (author), Kamenecki, Monika (author), Koscak Miocic-Stosic, Vesna (author), Melone, Antonella (author), Mertens, Elke (author), Meeres, Sophia (author), Ortacesme, Veli (author), Noortman, Adrian (author), Sárospataki, Máté (author), Stiles, Richard (author), Trolf, Norbert (author), Tóth, Attila (author), Tomic Reljic, Dora (author), Tudora, Ioana (author), Valdés Tejera, Esther (author), Valánszki, István (author), Weckman, Emilia (author), Williams, Tony (author), Tutundzic, Andreja (author), Lambertini, Anna (author), Mihova, Katinka (author), Muru, Toomas (author), Dam, Torben (author), Teqja, Zydi (author), Cipriani, L. (author), de Vries, Jeroen (author), Stauskis, Gintaras (author), Auweck, Fritz (author), Triboi, Roxana (author), Andreucci, Maria Beatrice (author), Cervera Alonso de Medina, Marina (author), Cancela d’ Abreu, Margarida (author), Freire, Maria (author), Carapinha, Aurora (author), a Conceição Castro, Maria (author), Del Pozo, Cristina (author), Deveikienė, Vaiva (author), Gunnlaugsson, Hermann Georg (author), Fekete, Albert (author), Fetzer, Ellen (author), Fabris, Luca (author), Fingerova, Radmila (author), Gazvoda, Davorin (author), Gkoltsiou, Aikaterini (author), Harmanescu, Mihaela (author), Kamenecki, Monika (author), Koscak Miocic-Stosic, Vesna (author), Melone, Antonella (author), Mertens, Elke (author), Meeres, Sophia (author), Ortacesme, Veli (author), Noortman, Adrian (author), Sárospataki, Máté (author), Stiles, Richard (author), Trolf, Norbert (author), Tóth, Attila (author), Tomic Reljic, Dora (author), Tudora, Ioana (author), Valdés Tejera, Esther (author), Valánszki, István (author), Weckman, Emilia (author), Williams, Tony (author), Tutundzic, Andreja (author), Lambertini, Anna (author), Mihova, Katinka (author), Muru, Toomas (author), Dam, Torben (author), and Teqja, Zydi (author)

Abstract

Landscape Architecture

Published
2021

26. Fragile airports. Fragile cities. Fragile landscapes

Author

Cipriani, L. (author) and Cipriani, L. (author)

Abstract

Recent events provide ample proof of the fragility of cities, territories and airport nodes when they come face-to-face with extreme and unexpected events. The Coronavirus pandemic, for example, has caused a complete disruption in the air network. Climate change, recurrent floods, rising seas, desertification, land impoverishment and, more generally, extreme meteorological events can temporarily or permanently compromise mobility networks and spaces. Airports are, in fact, highly vulnerable elements of infrastructure that require precise adaptation and mitigation strategies at various levels. What role can urban and landscape planning play in future decisions regarding new infrastructural sites and the adaptation of old infrastructure to climatic change and possible new functions?, Landscape Architecture

Published
2021
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27. Serum IgG2 antibody multi-composition in systemic lupus erythematosus and in lupus nephritis (Part 2): prospective study

Author

Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Angeletti, A, Ravelli, A, Ghiggeri, G, Bruschi, Maurizio, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe A, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, d'Alessandro, Matteo, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Prunotto, Marco, Verrina, Enrico, Angeletti, Andrea, Ravelli, Angelo, Ghiggeri, Gian Marco, Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Angeletti, A, Ravelli, A, Ghiggeri, G, Bruschi, Maurizio, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe A, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, d'Alessandro, Matteo, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Prunotto, Marco, Verrina, Enrico, Angeletti, Andrea, Ravelli, Angelo, and Ghiggeri, Gian Marco

Abstract

Objectives: Circulating anti-ENO1 and anti-H2A IgG2 have been identified as specific signatures of LN in a cross-over approach. We sought to show whether the same antibodies identify selected population of patients with LN with potentially different clinical outcomes. Methods: Here we report the prospective analysis over 36 months of circulating IgG2 levels in patients with newly diagnosed LN (n=91) and SLE (n=31) and in other patients with SLE recruited within 2 years from diagnosis (n=99). Anti-podocyte (ENO1), anti-nucleosome (DNA, histone 2 A, histone 3) and anti-circulating proteins (C1q, AnnexinA1-ANXA1) IgG2 antibodies were determined by home-made techniques. Results: LN patients were the main focus of the study. Anti-ENO1, anti-H2A and anti-ANXA1 IgG2 decreased in parallel to proteinuria and normalized within 12 months in the majority of patients while anti-dsDNA IgG2 remained high over the 36 months. Anti-ENO1 and anti-H2A had the highest association with proteinuria (Heat Map) and identified the highest number of patients with high proteinuria (68% and 71% respectively) and/or with reduced estimated glomerula filtration rate (eGFR) (58% for both antibodies) compared with 23% and 17% of anti-dsDNA (agreement analysis). Anti-ENO1 positive LN patients had higher proteinuria than negative patients at T0 and presented the maximal decrement within 12 months. Conclusions: Anti-ENO1, anti-H2A and anti-ANXA1 antibodies were associated with high proteinuria in LN patients and Anti-ENO1 also presented the maximal reduction within 12 months that paralleled the decrease of proteinuria. Anti-dsDNA were not associated with renal outcome parameters. New IgG2 antibody signatures should be utilized as tracers of personalized therapies in LN. Trial registration: The Zeus study was registered at https://clinicaltrials.gov (study number: NCT02403115).

Published
2021

28. Second wave antibodies in autoimmune renal diseases: The case of lupus nephritis

Author

Angeletti, A, Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Ravelli, A, Ghiggeri, G, Angeletti, Andrea, Bruschi, Maurizio, Moroni, Gabriela, Sinico, Renato, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, d'Alessandro, Matteo, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Prunotto, Marco, Verrina, Enrico, Ravelli, Angelo, Ghiggeri, Gian Marco, Angeletti, A, Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Ravelli, A, Ghiggeri, G, Angeletti, Andrea, Bruschi, Maurizio, Moroni, Gabriela, Sinico, Renato, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, d'Alessandro, Matteo, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Prunotto, Marco, Verrina, Enrico, Ravelli, Angelo, and Ghiggeri, Gian Marco

Abstract

Clinical Trial registry name and registration number: Zeus study, NCT02403115

Published
2021

29. Serum IgG2 antibody multicomposition in systemic lupus erythematosus and lupus nephritis (Part 1): cross-sectional analysis

Author

Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Volpi, S, Verrina, E, Angeletti, A, Ravelli, A, Ghiggeri, G, Bruschi, Maurizio, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela&nbsp, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello&nbsp, Manfredi, Angelo, Ramirez, Giuseppe A, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Mosca, Marta, Tincani, Angela&nbsp, Candiano, Giovanni, Prunotto, Marco, Volpi, Stefano, Verrina, Enrico, Angeletti, Andrea, Ravelli, Angelo, Ghiggeri, Gian Marco, Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Volpi, S, Verrina, E, Angeletti, A, Ravelli, A, Ghiggeri, G, Bruschi, Maurizio, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela&nbsp, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello&nbsp, Manfredi, Angelo, Ramirez, Giuseppe A, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Mosca, Marta, Tincani, Angela&nbsp, Candiano, Giovanni, Prunotto, Marco, Volpi, Stefano, Verrina, Enrico, Angeletti, Andrea, Ravelli, Angelo, and Ghiggeri, Gian Marco

Abstract

Objectives: Serum anti-dsDNA and anti-nucleosome IgGs have been proposed as signatures for SLE and LN in limited numbers of patients. We sought to show higher sensitivity and specificity of the same antibodies with the IgG2 isotype and included IgG2 antibodies vs specific intracellular antigens in the analysis. Methods: A total of 1052 SLE patients with (n = 479) and without (n = 573) LN, recruited at different times from the beginning of symptoms, were included in the study. Patients with primary APS (PAPS, n = 24), RA (RA, n = 24) and UCTD (UCTD, n = 96) were analysed for comparison. Anti-nucleosome (dsDNA, Histone2A, Histone3), anti-intracellular antigens (ENO1), anti-annexin A1 and anti-C1q IgG2 were determined by non-commercial techniques. Results: The presence in the serum of the IgG2 panel was highly discriminatory for SLE/LN vs healthy subjects. Serum levels of anti-dsDNA and anti-C1q IgG2 were more sensitive than those of IgGs (Farr radioimmunoassay/commercial assays) in identifying SLE patients at low-medium increments. Of more importance, serum positivity for anti-ENO1 and anti-H2A IgG2 discriminated between LN and SLE (ROC T0-12 months), and high levels at T0-1 month were detected in 63% and 67%, respectively, of LN, vs 3% and 3%, respectively, of SLE patients; serum positivity for each of these was correlated with high SLEDAI values. Minor differences existed between LN/SLE and the other rheumatologic conditions. Conclusion: Nephritogenic IgG2 antibodies represent a specific signature of SLE/LN, with a few overlaps with other rheumatologic conditions. High levels of anti-ENO1 and anti-H2A IgG2 correlated with SLE activity indexes and were discriminatory between SLE patients limited to the renal complication and other SLE patients. Trial registration: The Zeus study was registered at https://clinicaltrials.gov, NCT02403115.

Published
2021

31. Serum IgG2 antibody multi composition in systemic lupus erythematosus and in lupus nephritis

Author

Bruschi, M, Moroni, G, Sinico, Ra, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, Ga, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Angeletti, A, Ravelli, A, and Ghiggeri, Gm.

Published
2020

33. More nature in the city

Author

Capotorti, G, primary, Bonacquisti, S, additional, Abis, L, additional, Aloisi, I, additional, Attorre, F, additional, Bacaro, G, additional, Balletto, G, additional, Banfi, E, additional, Barni, E, additional, Bartoli, F, additional, Bazzato, E, additional, Beccaccioli, M, additional, Braglia, R, additional, Bretzel, F, additional, Brighetti, M. A, additional, Brundu, G, additional, Burnelli, M, additional, Calfapietra, C, additional, Cambria, V. E, additional, Caneva, G, additional, Canini, A, additional, Caronni, S, additional, Castello, M, additional, Catalano, C, additional, Celesti-Grapow, L, additional, Cicinelli, E, additional, Cipriani, L, additional, Citterio, S, additional, Concu, G, additional, Coppi, A, additional, Corona, E, additional, Del Duca, S, additional, Del, Vico E, additional, Di Gristina, E, additional, Domina, G, additional, Faino, L, additional, Fano, E. A, additional, Fares, S, additional, Farris, E, additional, Farris, S, additional, Fornaciari, M, additional, Gaglio, M, additional, Galasso, G, additional, Galletti, M, additional, Gargano, M. L, additional, Gentili, R, additional, Giannotta, A. P, additional, Guarino, C, additional, Guarino, R, additional, Iaquinta, G, additional, Iiriti, G, additional, Lallai, A, additional, Lallai, E, additional, Lattanzi, E, additional, Manca, S, additional, Manes, F, additional, Marignani, M, additional, Marinangeli, F, additional, Mariotti, M, additional, Mascia, F, additional, Mazzola, P, additional, Meloni, G, additional, Michelozzi, P, additional, Miraglia, A, additional, Montagnani, C, additional, Mundula, L, additional, Muresan, A. N, additional, Musanti, F, additional, Nardini, A, additional, Nicosia, E, additional, Oddi, L, additional, Orlandi, F, additional, Pace, R, additional, Palumbo, M. E, additional, Palumbo, S, additional, Parrotta, L, additional, Pasta, S, additional, Perini, K, additional, Poldini, L, additional, Postiglione, A, additional, Prigioniero, A, additional, Proietti, C, additional, Raimondo, F. M, additional, Ranfa, A, additional, Redi, E. L, additional, Reverberi, M, additional, Roccotiello, E, additional, Ruga, L, additional, Savo, V, additional, Scarano, P, additional, Schirru, F, additional, Sciarrillo, R, additional, Scuderi, F, additional, Sebastiani, A, additional, Siniscalco, C, additional, Sordo, A, additional, Suanno, C, additional, Tartaglia, M, additional, Tilia, A, additional, Toffolo, C, additional, Toselli, E, additional, Travaglini, A, additional, Ventura, F, additional, Venturella, G, additional, Vincenzi, F, additional, and Blasi, C, additional

Published
2020
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45. TUTELA DELLA FERTILITÀ NELLE PAZIENTI A RICHIO DI ESAURIMENTO OVARIO PRECOCE

Author

PORCU, ELEONORA, DAMIANO, GIUSEPPE, VENTUROLI, STEFANO, Cipriani L, Bianchi A, Albonetti F, Zorzi C, Dirodi M, Amicucci S, Landolfo C, Porcu E, Cipriani L, Damiano G, Bianchi A, Albonetti F, Zorzi C, Dirodi M, Amicucci S, Landolfo C, and Venturoli S.

Abstract

L'ESAURIMENTO OVARICO PRECOCE (POF) E' UNA MALATTIA FREQUENTE ED ETEROGENEA CHE ANTICIPA IL FISIOLOGICO ESAURIMENTO FUNZIONALE DELL'OVAIO.

Published
2010

46. Benign paroxysmal positional vertigo and migraine: analysis of 186 cases

Author

Faralli, M, Cipriani, L, Del Zompo MR, Panichi, Roberto, Calzolaro, L, and Ricci, Giampietro

Subjects
Adult, Male, adult, article, benign paroxysmal positional vertigo, comparative study, female, human, male, middle aged, migraine, retrospective study, vertigo, retrospective study, Migraine Disorders, article, Middle Aged, Vertigo, Humans, migraine, Female, human, Benign Paroxysmal Positional Vertigo, comparative study, Retrospective Studies
Abstract

This retrospective study assessed several clinical, case history and functional parameters to investigate benign paroxysmal positional vertigo (BPPV) in patients with migraine.Two groups of patients were compared: those affected by BPPV and migraine (group A), as defined by International Headache Society criteria, and those with BPPV without migraine or with another form of headache (group B). The following parameters were investigated: onset of BPPV, recovery time, residual dizziness, recurrence of BPPV, atypical eye movement patterns and Meniere-like vertigo in the inter-critical BPPV period.Mean age at BPPV onset was 39 years +/- 9.2 in Group A and 53 years +/- 7.3 in Group B (p = 0.00). No significant difference emerged in the number of manoeuvres needed to achieve recovery (Group A: 1.7 +/- 0.94; Group B: 1.9 +/- 0.89; p0.05). Highly recurrent BPPV (at least 4 documented episodes) was observed in 15 patients from group A (19.4%) and in 8 patients from group B (7.3%). Atypical eyes movements and Meniere-like vertigo were more frequent in migraineurs with highly recurrent BPPV (Chi square = 5.76; p0.016).A high prevalence of BPPV and earlier onset in migraine are the main findings of this study. There is a higher incidence of a range of neurotological patterns in the intervals between BPPV episodes in migraineurs with recurrent vertigo. No direct pathophysiological link between migraine and BPPV has yet been established; comorbidity seems to affect clinical features in a sub-population of patients and make BPPV more debilitating.

Published
2014

50. Preclinical phase of Alzheimer's disease: Guideline for recognition and study of patients with mild cognitive impairment

Author

Caltagirone C, Perri R, Musicco M, Alberoni M, Apollonio I, Bonaiuto S, Bottini G, Caffarra R, Carlomagno S, Carolei A, Cipriani L, Di Luca M, De Bastiani R, Franceschi M, Frisoni G, Gallucci M, Gambina G, Ghidoni E, Girotti F, Giubilei F, Lorusso S, Marchetti C, Monastero R, Padovani A, Perini M, Pettenati C, Piras MR, Postiglione A, Provinciali L, Quartarone A, Rinaldi A, Senin U, Mecocci P, Sozzi G, Tognoni C, Zagnoni P, Grossi E, Savarà R, and Caltagirone C, Perri R, Musicco M, Alberoni M, Apollonio I, Bonaiuto S, Bottini G, Caffarra R, Carlomagno S, Carolei A, Cipriani L, Di Luca M, De Bastiani R, Franceschi M, Frisoni G, Gallucci M, Gambina G, Ghidoni E, Girotti F, Giubilei F, Lorusso S, Marchetti C, Monastero R, Padovani A, Perini M, Pettenati C, Piras MR, Postiglione A, Provinciali L, Quartarone A, Rinaldi A, Senin U, Mecocci P, Sozzi G, Tognoni C, Zagnoni P, Grossi E, Savarè R

Subjects
mild cognitive impairment, Alzheimer Disease, Settore MED/26 - Neurologia
Published
2002

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