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3. Abnormal production of tumor necrosis factor (TNF) -- alpha and clinical efficacy of the TNF inhibitor etanercept in a patient with PAPA syndrome [corrected].

Author

Cortis E, De Benedetti F, Insalaco A, Cioschi S, Muratori F, D'Urbano LE, and Ugazio AG

Subjects
Acne Vulgaris drug therapy, Acne Vulgaris genetics, Adaptor Proteins, Signal Transducing genetics, Adolescent, Adult, Arthritis drug therapy, Arthritis genetics, Child, Child, Preschool, Cytoskeletal Proteins genetics, Etanercept, Female, Humans, Male, Pyoderma drug therapy, Pyoderma genetics, Syndrome, Tumor Necrosis Factor-alpha biosynthesis, Acne Vulgaris complications, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Arthritis complications, Immunoglobulin G therapeutic use, Pyoderma complications, Receptors, Tumor Necrosis Factor therapeutic use, Tumor Necrosis Factor-alpha antagonists & inhibitors
Abstract

We report a family with pyogenic sterile arthritis, pyoderna and acne syndrome (PAPA). The proband presented several episodes of sterile pyogenic arthritis and became unresponsive to glucocorticoids. After treatment with the tumor necrosis factor inhibitor etanercept, the disease underwent rapid and sustained clinical remission. Production of tumor necrosis factor-alpha by mononuclear cells of the proband and of the affected relatives was abnormally elevated.

Published
2004
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4. Detection and clinical evaluation of GBV-C/HGV in plasma from patients with chronic hepatitis of unknown etiology.

Author

Grassi M, Raffa S, Traditi F, Ferrazzi M, Cioschi S, Fontana M, and Pezzella M

Subjects
Adult, Electrophoresis, Female, Flaviviridae genetics, Humans, Male, Middle Aged, RNA, Viral isolation & purification, Reverse Transcriptase Polymerase Chain Reaction, Flaviviridae isolation & purification, Hepatitis, Viral, Human diagnosis, Hepatitis, Viral, Human virology
Abstract

Purpose: The role of GBV-C/HGV virus infection in patients with chronic hepatitis of unknown etiology has been studied. Two groups of patients have been included: a) 50 consecutive patients with chronic hepatitis (mean age 47 yrs; M/F = 35/15), negative for markers of hepatitis viruses (HBV-HCV). These patients did not show evidence of metabolic, autoimmune, alcoholic or toxic liver disease; b) 50 healthy blood donors (mean age 35 yrs; M/F = 35/15). All the subjects were HIV-seronegative., Patients and Methods: The detection of GBV-C/HGV RNA was performed by reverse transcription-polymerase chain reaction techniques and capillary zone electrophoresis analysis (CZE)., Results: There was no difference between the two groups of patients (14% vs 6%; p = 0.18 NS)., Conclusions: The etiopathogenetic role of GBV-C/HGV in chronic hepatitis of unknown etiology is yet to be shown.

Published
2000

5. [Adrenal hemorrhagic cysts: apropos of a clinical case and review of the literature].

Author

Forte A, Gallinaro LS, Angelici A, Soda G, Bosco D, Cioschi S, Bisanti AM, Grassi M, and Bezzi M

Subjects
Adrenal Gland Diseases diagnosis, Adrenal Gland Diseases pathology, Adrenal Glands pathology, Adult, Cysts diagnosis, Cysts pathology, Diagnosis, Differential, Humans, Male, Tomography, X-Ray Computed, Adrenal Gland Diseases surgery, Cysts surgery, Hemorrhage diagnosis, Hemorrhage pathology
Abstract

Adrenal cysts are uncommon lesion and present complex problems in differential diagnosis. The treatment options are not univocal. Starting from the study of a personal case the authors review the existing literature and discuss the problem of diagnosis and treatment.

Published
1998

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